Lisinopril

Generic name: Pronounced as (lyse in' oh pril)
Brand names
  • Prinivil®
  • Qbrelis®
  • Zestoretic® (containing Hydrochlorothiazide, Lisinopril)
  • Zestril®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 02/15/2021

Do not take lisinopril if you are pregnant. If you become pregnant while taking lisinopril, call your doctor immediately. Lisinopril may harm the fetus.

Lisinopril is used alone or in combination with other medications to treat high blood pressure in adults and children 6 years of age and older. It is used in combination with other medications to treat heart failure. Lisinopril is also used to improve survival after a heart attack. Lisinopril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly and the heart can pump blood more efficiently.

High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys, and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

Lisinopril comes as a tablet and a solution (liquid) to take by mouth. It is usually taken once a day. To help you remember to take lisinopril, take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lisinopril exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you are taking the solution, do not use a household spoon to measure your dose. Use an oral syringe made especially for measuring liquid medication.

Your doctor will probably start you on a low dose of lisinopril and gradually increase your dose.

Lisinopril controls your condition, but it is not a cure. Continue to take lisinopril even if you feel well. Do not stop taking lisinopril without talking to your doctor.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking lisinopril,

  • tell your doctor and pharmacist if you are allergic to lisinopril; other ACE inhibitors such as enalapril (Vasotec, in Vaseretic), benazepril (Lotensin, in Lotrel), captopril (Capoten), fosinopril (Monopril), moexipril (Univasc, in Uniretic), perindopril (Aceon), quinapril (Accupril, in Accuretic, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); any other medications; or any ingredients in lisinopril tablets and solution. Ask your pharmacist for a list of the ingredients.

  • tell your doctor or pharmacist if you are taking valsartan and sacubitril (Entresto) or if you have stopped taking it within the last 36 hours. Your doctor will probably tell you not to take lisinopril, if you are also taking valsartan and sacubitril. Also, tell your doctor if you have diabetes and you are taking aliskiren (Tekturna, in Amturnide, Tekamlo, Tekturna HCT). Your doctor will probably tell you not to take lisinopril if you have diabetes and you are also taking aliskiren.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as diuretics ('water pills'); everolimus (Zortress); gold compounds; indomethacin (Indocin, Tivorbex); insulin or other medications to treat diabetes; lithium (Lithobid); potassium supplements; sirolimus (Rapamune); and temsirolimus (Torisel). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have had certain types of angioedema (a condition that causes difficulty swallowing or breathing and painful swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs). Your doctor will probably tell you not to take lisinopril.

  • tell your doctor if you have or have ever had heart or kidney disease or diabetes.

  • tell your doctor if you are breastfeeding.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking lisinopril.

  • you should know that diarrhea, vomiting, not drinking enough fluids, and sweating a lot can cause a drop in blood pressure, which may cause lightheadedness and fainting.

Talk to your doctor before using salt substitutes containing potassium. If your doctor prescribes a low-salt or low-sodium diet, follow these directions carefully.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Lisinopril may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • cough

    • dizziness

    • headache

    • excessive tiredness

    • nausea

    • diarrhea

    • weakness

    • sneezing

    • runny nose

    • decrease in sexual ability

    • rash

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

    • hoarseness

    • difficulty breathing or swallowing

    • fever, sore throat, chills, and other signs of infection

    • yellowing of the skin or eyes

    • lightheadedness

    • fainting

    • chest pain

  • Lisinopril may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • lightheadedness

  • fainting

Keep all appointments with your doctor and the laboratory. Your blood pressure should be checked regularly to determine your response to lisinopril. Your doctor may order certain lab tests to check your body's response to lisinopril.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Naratriptan Naratriptan Naratriptan may decrease the antihypertensive activities of Lisinopril.
Penbutolol Penbutolol The risk or severity of hyperkalemia can be increased when Lisinopril is combined with Acebutolol.
Zolmitriptan Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Lisinopril.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Lisinopril may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Trimipramine Trimipramine Trimipramine may decrease the antihypertensive activities of Lisinopril.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Apomorphine Injection Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Lisinopril.
Tinidazole Tinidazole Lisinopril may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Rasagiline Rasagiline Rasagiline may increase the hypotensive activities of Lisinopril.
Rituximab Injection Rituximab Injection Lisinopril may increase the hypotensive activities of Rituximab.
Azacitidine Injection Azacitidine Injection Lisinopril may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Doripenem Injection Doripenem Injection Lisinopril may decrease the excretion rate of Doripenem which could result in a higher serum level.
Tretinoin Tretinoin The risk or severity of adverse effects can be increased when Tretinoin is combined with Lisinopril.
Betaxolol Betaxolol The risk or severity of hyperkalemia can be increased when Betaxolol is combined with Lisinopril.
Everolimus Everolimus The risk or severity of adverse effects can be increased when Everolimus is combined with Lisinopril.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Lurasidone Lurasidone Lurasidone may decrease the antihypertensive activities of Lisinopril.
Vilazodone Vilazodone Vilazodone may decrease the antihypertensive activities of Lisinopril.
Ipilimumab Injection Ipilimumab Injection Lisinopril may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Lisinopril may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Azilsartan Azilsartan The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Lisinopril is combined with Azilsartan medoxomil.
Roflumilast Roflumilast Lisinopril may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Linagliptin Linagliptin The risk or severity of angioedema can be increased when Lisinopril is combined with Linagliptin.
Rivaroxaban Rivaroxaban Lisinopril may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ruxolitinib Ruxolitinib Lisinopril may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Deferiprone Deferiprone Lisinopril may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Enzalutamide Enzalutamide Lisinopril may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron Mirabegron Lisinopril may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Teduglutide Injection Teduglutide Injection Lisinopril may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Alogliptin Alogliptin The risk or severity of angioedema can be increased when Lisinopril is combined with Alogliptin.
Pomalidomide Pomalidomide Lisinopril may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
Canagliflozin Canagliflozin The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Lisinopril is combined with Canagliflozin.
Trametinib Trametinib Lisinopril may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran Lisinopril may decrease the excretion rate of Levomilnacipran which could result in a higher serum level.
Vortioxetine Vortioxetine Lisinopril may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Avanafil Avanafil Avanafil may increase the antihypertensive activities of Lisinopril.
Sofosbuvir Sofosbuvir Lisinopril may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Dapagliflozin is combined with Lisinopril.
Apremilast Apremilast Lisinopril may decrease the excretion rate of Apremilast which could result in a higher serum level.
Droxidopa Droxidopa Lisinopril may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Testosterone Injection Testosterone Injection Testosterone may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Empagliflozin Empagliflozin The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Empagliflozin is combined with Lisinopril.
Tasimelteon Tasimelteon Lisinopril may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Riociguat Riociguat Lisinopril may increase the hypotensive activities of Riociguat.
Macitentan Macitentan Lisinopril may decrease the excretion rate of Macitentan which could result in a higher serum level.
Ziprasidone Injection Ziprasidone Injection Ziprasidone may increase the antihypertensive activities of Lisinopril.
Lixisenatide Injection Lixisenatide Injection Lisinopril may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives Lisinopril may increase the hyperkalemic activities of Drospirenone.
Viloxazine Viloxazine Lisinopril may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Tolmetin Tolmetin The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Tolmetin is combined with Lisinopril.
Sulindac Sulindac The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Sulindac is combined with Lisinopril.
Trazodone Trazodone Trazodone may decrease the antihypertensive activities of Lisinopril.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Tranylcypromine Tranylcypromine Tranylcypromine may increase the hypotensive activities of Lisinopril.
Tetracycline Tetracycline Lisinopril may decrease the excretion rate of Tetracycline which could result in a higher serum level.
Thioridazine Thioridazine Thioridazine may decrease the antihypertensive activities of Lisinopril.
Trifluoperazine Trifluoperazine Trifluoperazine may decrease the antihypertensive activities of Lisinopril.
Sulfadiazine Sulfadiazine Sulfadiazine may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Benztropine Benztropine Benzatropine may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Azathioprine Azathioprine The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Lisinopril is combined with Azathioprine.
Warfarin Warfarin Lisinopril may decrease the excretion rate of Warfarin which could result in a higher serum level.
Triamterene Triamterene The risk or severity of hyperkalemia can be increased when Triamterene is combined with Lisinopril.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Tolbutamide Tolbutamide Lisinopril may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolazamide Tolazamide Lisinopril may decrease the excretion rate of Tolazamide which could result in a higher serum level.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Lisinopril.
Aspirin Aspirin The therapeutic efficacy of Lisinopril can be decreased when used in combination with Acetylsalicylic acid.
Temazepam Temazepam Temazepam may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Triazolam Triazolam Lisinopril may decrease the excretion rate of Triazolam which could result in a higher serum level.
Trimethoprim Trimethoprim Trimethoprim may increase the hyperkalemic activities of Lisinopril.
Timolol Timolol The risk or severity of hyperkalemia can be increased when Timolol is combined with Lisinopril.
Verapamil Verapamil Verapamil may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Atenolol Atenolol The risk or severity of hyperkalemia can be increased when Atenolol is combined with Lisinopril.
Auranofin Auranofin Lisinopril may decrease the excretion rate of Auranofin which could result in a higher serum level.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Epoetin Alfa, Injection Epoetin Alfa, Injection The serum concentration of Erythropoietin can be decreased when it is combined with Lisinopril.
Tramadol Tramadol Tramadol may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Ticlopidine Ticlopidine Ticlopidine may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection Gemcitabine may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Sildenafil Sildenafil Sildenafil may increase the antihypertensive activities of Lisinopril.
Celecoxib Celecoxib The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Celecoxib is combined with Lisinopril.
Tolterodine Tolterodine Lisinopril may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Thalidomide Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Lisinopril.
Rabeprazole Rabeprazole Lisinopril may decrease the excretion rate of Rabeprazole which could result in a higher serum level.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists