Trazodone

124 interactions 7 explained in plain English
Also sold as: Raldesy
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Trazodone Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of serotonin syndrome and an increased risk of CNS depression Details Trazodone Abametapir Explained Increased exposure of CYP3A4 substrate Details Trazodone Amitriptyline Elavil Explained Increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Trazodone Sertraline Explained Increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Trazodone Buprenorphine Belbuca Explained Increased risk of QT interval prolongation, an increased risk of serotonin syndrome and an increased risk of CNS depression Details Trazodone Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Trazodone Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Trazodone Apixaban Eliquis Explained Increased risk of bleeding Details Trazodone Arsenic Trioxide Trisenox An increased risk of QT interval prolongation and an increased risk of cardiac arrythmia Details Trazodone Aripiprazole Injection Abilify Increased risk of CNS depression and an increased risk of QT interval prolongation Details Trazodone Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation and an increased risk of cardiac arrythmia Details Trazodone Asenapine Transdermal Patch Secuado Increased risk of CNS depression and an increased risk of QT interval prolongation Details Trazodone Aspirin Acuprin® An increased risk of bleeding Details Trazodone Aspirin Rectal Aspirin An increased risk of bleeding Details Trazodone Azithromycin AzaSite An increased risk of QT interval prolongation and an increased risk of cardiac arrythmia Details Trazodone Betrixaban Bevyxxa® Increased risk of bleeding Details Trazodone Alfuzosin UroXatral An increased risk of QT interval prolongation and an increased risk of cardiac arrythmia Details Trazodone Anagrelide Agrylin Increased risk of QT interval prolongation and an increased risk of bleeding Details Trazodone Bedaquiline Sirturo An increased risk of QT interval prolongation and an increased risk of cardiac arrythmia Details Trazodone Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Trazodone Butorphanol Injection Butorphic An increased risk of serotonin syndrome and an increased risk of CNS depression Details Trazodone Butorphanol Nasal Spray Stadol® NS An increased risk of serotonin syndrome and an increased risk of CNS depression Details Trazodone Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Trazodone Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Trazodone Chloroquine Aralen® An increased risk of QT interval prolongation and an increased risk of cardiac arrythmia Details Trazodone Clopidogrel Plavix Increased risk of bleeding Details Trazodone Dabigatran Pradaxa® Increased risk of bleeding Details Trazodone Dabigatran Etexilate Increased risk of bleeding Details Trazodone Dalteparin Injection Fragmin Increased risk of bleeding Details Trazodone Dasatinib Phyrago An increased risk of QT interval prolongation Details Trazodone Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Trazodone Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Trazodone Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Trazodone Diazepam Rectal Diastat Increased risk of CNS depression Details Trazodone Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Trazodone Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Trazodone Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Trazodone Diclofenac Transdermal Patch Flector An increased risk of bleeding Details

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