Sertraline

Sertraline is used to treat depression, obsessive-compulsive disorder (bothersome thoughts that won't go away and the need to perform certain actions over and over), panic attacks (sudden, unexpected attacks of extreme fear and worry about these attacks), posttraumatic stress disorder (disturbing psychological symptoms that develop after a frightening experience), and social anxiety disorder (extreme fear of interacting with others or performing in front of others that interferes with normal life). It is also used to relieve the symptoms of premenstrual dysphoric disorder, including mood swings, irritability, bloating, and breast tenderness. Sertraline is in a class of antidepressants called selective serotonin reuptake inhibitors (SSRIs). It works by increasing the amounts of serotonin, a natural substance in the brain that helps maintain mental balance.

Sertraline comes as a tablet and a concentrate (liquid) to take by mouth. It is usually taken once daily in the morning or evening. To treat premenstrual dysphoric disorder, sertraline is taken once a day, either every day of the month or on certain days of the month. Take sertraline at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sertraline exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Sertraline concentrate must be diluted before use. Immediately before taking it, use the provided dropper to remove the amount of concentrate your doctor has told you to take. Mix the concentrate with 4 ounces (1/2 cup [120 milliliters]) of water, ginger ale, lemon or lime soda, lemonade, or orange juice. After mixing, the diluted solution may be hazy; this is normal. Do not mix the concentrate with any liquids other than the ones listed. Drink the diluted solution immediately.

Your doctor may start you on a low dose of sertraline and gradually increase your dose, not more than once a week.

It may take a few weeks or longer before you feel the full benefit of sertraline. Continue to take sertraline even if you feel well. Do not stop taking sertraline without talking to your doctor. If you suddenly stop taking sertraline, you may experience withdrawal symptoms such as nausea, sweating, depression, mood changes, frenzied or abnormally excited mood, irritability, anxiety, confusion, dizziness, headache, tiredness, seizures, ringing in the ears, numbness or tingling in the arms, legs, hands, or feet, difficulty falling asleep or staying asleep.

Sertraline is also used sometimes to treat headaches and sexual problems. Talk to your doctor about the possible risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking sertraline,

• tell your doctor and pharmacist if you are allergic to sertraline, any other medications, any of the ingredients in sertraline preparations, or latex (found in the dropper for the concentrate). Before taking sertraline liquid concentrate, tell your doctor if you are allergic to latex. Ask your pharmacist for a list of the ingredients.

• tell your doctor if you are taking monoamine oxidase (MAO) inhibitors including isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Emsam, Zelapar), and tranylcypromine (Parnate), or have stopped taking them within the past 2 weeks, or if you are taking pimozide (Orap). Your doctor will probably tell you not to take sertraline. If you stop taking sertraline, you should wait at least 2 weeks before you start to take an MAO inhibitor.

• do not take disulfiram (Antabuse) while taking sertraline oral concentrate.

• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Nexterone, Pacerone); amphetamines; anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven) and heparin; aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); atomoxetine (Straterra); buspirone, chlorpromazine; clopidogrel (Plavix), dextromethorphan (found in many cough medications; in Nuedexta); fentanyl (Actiq, Fentora, Lazanda, others), droperidol (Inapsine); erythromycin (E.E.S, Eryc, Ery-tab, others); fosphenytoin (Cerebyx); iloperidone (Fanapt); lithium (Lithobid); medications for anxiety, mental illness, Parkinson's disease, and seizures; medications for irregular heartbeat such as flecainide and propafenone (Rythmol); metoprolol (Lopressor, Toprol XL); medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); mefloquine; methadone (Dolophine, Methadose); moxifloxacin (Avelox); nebivolol (Bystolic, in Byvalson); pentamidine (Nebupent, Pentam); perphenazine; phenytoin (Dilantin, Phenytek); procainamide; quinidine (in Nuedexta); sedatives; sleeping pills; other selective serotonin-reuptake inhibitors such as citalopram (Celexa), fluoxetine (Prozac), or fluvoxamine (Luvox); serotonin–norepinephrine reuptake inhibitors (SNRI) medications such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), levomilnacipran (Fetzima), and venlafaxine; sotalol (Betapace, Sotylize); tacrolimus (Astagraf, Envarsus XR, Prograf); thioridazine; tolterodine (Detrol); tramadol (Conzip, Qdolo, Ultram); tranquilizers; tricyclic antidepressants ('mood elevators') such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin, imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine; or ziprasidone (Geodon). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with sertraline, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

• tell your doctor what herbal products and nutritional supplements you are taking, especially St. John's wort and tryptophan.

• tell your doctor if you have recently had a heart attack or stroke or if you have high blood pressure, bleeding problems, a low level of sodium in your blood and if you have or have ever had seizures or liver, kidney, or heart disease.

• tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, or if you plan to become pregnant or are breastfeeding. If you become pregnant while taking sertraline, call your doctor. Sertraline may cause problems in newborns following delivery if it is taken during the last months of pregnancy.

• you should know that sertraline may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.

• ask your doctor about the safe use of alcoholic beverages while you are taking sertraline.

• you should know that sertraline may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Sertraline may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea

  • diarrhea

  • constipation

  • vomiting

  • difficulty falling asleep or staying asleep

  • dry mouth

  • heartburn

  • loss of appetite

  • weight changes

  • dizziness

  • excessive tiredness

  • headache

  • nervousness

  • uncontrollable shaking of a part of the body

  • sexual problems in males; decreased sex drive, inability to get or keep an erection, or delayed or absent ejaculation

  • sexual problems in females; decreased sex drive, or delayed orgasm or unable to have an orgasm

  • excessive sweating

• Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS section, call your doctor immediately:

  • seizures

  • abnormal bleeding or bruising

  • agitation, hallucinations, fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea

  • headache, weakness, unsteadiness, confusion, or memory problems

  • rash

  • hives

  • swelling

  • difficulty breathing

• Sertraline may decrease appetite and cause weight loss in children. Your child's doctor will watch his or her growth carefully. Talk to your child's doctor if you have concerns about your child's growth or weight while he or she is taking this medication. Talk to your child's doctor about the risks of giving sertraline to your child.

• Sertraline may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

• drowsiness

• agitation, hallucinations, fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea

• excessive tiredness

• dizziness

• agitation

• mania

• seizures

• loss of consciousness

• dizziness

• rapid, irregular, or pounding heartbeat

Keep all appointments with your doctor.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking sertraline.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Repaglinide	Repaglinide The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Sertraline.
Montelukast	Montelukast The metabolism of Montelukast can be decreased when combined with Sertraline.
Insulin Glargine (rDNA origin) Injection	Insulin Glargine (rDNA origin) Injection The risk or severity of hypoglycemia can be increased when Insulin glargine is combined with Sertraline.
Leflunomide	Leflunomide The metabolism of Sertraline can be decreased when combined with Leflunomide.
Delavirdine	Delavirdine The metabolism of Sertraline can be decreased when combined with Delavirdine.
Nevirapine	Nevirapine The metabolism of Nevirapine can be decreased when combined with Sertraline.
Dolasetron	Dolasetron The risk or severity of adverse effects can be increased when Dolasetron is combined with Sertraline.
Anagrelide	Anagrelide The risk or severity of bleeding can be increased when Sertraline is combined with Anagrelide.
Candesartan	Candesartan The metabolism of Candesartan can be decreased when combined with Sertraline.
Cilostazol	Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Sertraline.
Clopidogrel	Clopidogrel The serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Sertraline resulting in a loss in efficacy.
Diphenoxylate	Diphenoxylate The risk or severity of serotonin syndrome can be increased when Diphenoxylate is combined with Sertraline.
Fenofibrate	Fenofibrate The metabolism of Sertraline can be decreased when combined with Fenofibrate.
Guanfacine	Guanfacine The risk or severity of adverse effects can be increased when Guanfacine is combined with Sertraline.
Miglitol	Miglitol The risk or severity of hypoglycemia can be increased when Miglitol is combined with Sertraline.
Naratriptan	Naratriptan The risk or severity of adverse effects can be increased when Naratriptan is combined with Sertraline.
Olsalazine	Olsalazine The risk or severity of bleeding can be increased when Sertraline is combined with Olsalazine.
Paregoric	Paregoric The risk or severity of serotonin syndrome can be increased when Morphine is combined with Sertraline.
Penbutolol	Penbutolol The metabolism of Sertraline can be decreased when combined with Acebutolol.
Pentazocine	Pentazocine The risk or severity of serotonin syndrome can be increased when Pentazocine is combined with Sertraline.
Ranitidine	Ranitidine The metabolism of Sertraline can be decreased when combined with Ranitidine.
Reserpine	Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Sertraline.
Rizatriptan	Rizatriptan The risk or severity of adverse effects can be increased when Rizatriptan is combined with Sertraline.
Sumatriptan	Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Sertraline.
Tizanidine	Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Sertraline.
Zolmitriptan	Zolmitriptan The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Sertraline.
Fluconazole Injection	Fluconazole Injection The metabolism of Sertraline can be decreased when combined with Fluconazole.
Hydromorphone Injection	Hydromorphone Injection The risk or severity of serotonin syndrome can be increased when Hydromorphone is combined with Sertraline.
Meperidine Injection	Meperidine Injection The risk or severity of serotonin syndrome can be increased when Sertraline is combined with Meperidine.
Metoclopramide Injection	Metoclopramide Injection The risk or severity of sedation can be increased when Metoclopramide is combined with Sertraline.
Metronidazole Injection	Metronidazole Injection The metabolism of Sertraline can be decreased when combined with Metronidazole.
Morphine Injection	Morphine Injection The risk or severity of serotonin syndrome can be increased when Morphine is combined with Sertraline.
Zidovudine Injection	Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Sertraline.
Altretamine	Altretamine The risk or severity of serotonin syndrome can be increased when Amphetamine is combined with Sertraline.
Cyclosporine	Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Sertraline.
Ondansetron	Ondansetron The risk or severity of adverse effects can be increased when Ondansetron is combined with Sertraline.
Enoxaparin Injection	Enoxaparin Injection The risk or severity of bleeding can be increased when Sertraline is combined with Enoxaparin.
Granisetron	Granisetron The risk or severity of adverse effects can be increased when Granisetron is combined with Sertraline.
Torsemide	Torsemide The metabolism of Sertraline can be decreased when combined with Torasemide.
Olanzapine	Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Sertraline.
Alosetron	Alosetron The risk or severity of adverse effects can be increased when Alosetron is combined with Sertraline.
Entacapone	Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Sertraline.
Hydroxychloroquine	Hydroxychloroquine The metabolism of Sertraline can be decreased when combined with Hydroxychloroquine.
Meloxicam	Meloxicam The risk or severity of bleeding can be increased when Sertraline is combined with Meloxicam.
Oxcarbazepine	Oxcarbazepine The risk or severity of adverse effects can be increased when Oxcarbazepine is combined with Sertraline.
Pantoprazole	Pantoprazole The metabolism of Sertraline can be decreased when combined with Pantoprazole.
Telmisartan	Telmisartan The metabolism of Sertraline can be decreased when combined with Telmisartan.
Zaleplon	Zaleplon The risk or severity of adverse effects can be increased when Zaleplon is combined with Sertraline.
Anakinra	Anakinra The metabolism of Sertraline can be increased when combined with Anakinra.
Desloratadine	Desloratadine The risk or severity of adverse effects can be increased when Desloratadine is combined with Sertraline.
Linezolid	Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Sertraline.
Pentosan Polysulfate	Pentosan Polysulfate The risk or severity of bleeding can be increased when Sertraline is combined with Pentosan polysulfate.
Trimipramine	Trimipramine The metabolism of Sertraline can be decreased when combined with Trimipramine.
Etanercept Injection	Etanercept Injection The metabolism of Sertraline can be increased when combined with Etanercept.
Glycopyrrolate	Glycopyrrolate Sertraline may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Modafinil	Modafinil The metabolism of Sertraline can be decreased when combined with Modafinil.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate The risk or severity of bleeding can be increased when Sertraline is combined with Choline magnesium trisalicylate.
Epinephrine Injection	Epinephrine Injection The metabolism of Sertraline can be decreased when combined with Epinephrine.
Escitalopram	Escitalopram The risk or severity of serotonin syndrome can be increased when Sertraline is combined with Escitalopram.
Zonisamide	Zonisamide The risk or severity of adverse effects can be increased when Zonisamide is combined with Sertraline.
Adalimumab Injection	Adalimumab Injection The metabolism of Sertraline can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole The serum concentration of Aripiprazole can be increased when it is combined with Sertraline.
Atomoxetine	Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Sertraline.
Dexmethylphenidate	Dexmethylphenidate The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with Sertraline.
Teriparatide Injection	Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Sertraline.
Atazanavir	Atazanavir The metabolism of Sertraline can be decreased when combined with Atazanavir.
Almotriptan	Almotriptan The risk or severity of adverse effects can be increased when Almotriptan is combined with Sertraline.
Eletriptan	Eletriptan The metabolism of Eletriptan can be decreased when combined with Sertraline.
Mefloquine	Mefloquine The metabolism of Sertraline can be decreased when combined with Mefloquine.
Rosuvastatin	Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Sertraline.
Aprepitant	Aprepitant The metabolism of Sertraline can be decreased when combined with Aprepitant.
Memantine	Memantine The metabolism of Sertraline can be decreased when combined with Memantine.
Tegaserod	Tegaserod The metabolism of Tegaserod can be decreased when combined with Sertraline.
Frovatriptan	Frovatriptan The risk or severity of adverse effects can be increased when Frovatriptan is combined with Sertraline.
Progesterone	Progesterone The metabolism of Progesterone can be decreased when combined with Sertraline.
Apomorphine Injection	Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Sertraline.
Infliximab Injection	Infliximab Injection The metabolism of Sertraline can be increased when combined with Infliximab.
Oxandrolone	Oxandrolone The metabolism of Sertraline can be decreased when combined with Oxandrolone.
Protriptyline	Protriptyline The risk or severity of adverse effects can be increased when Protriptyline is combined with Sertraline.
Rifaximin	Rifaximin The metabolism of Sertraline can be increased when combined with Rifaximin.
Duloxetine	Duloxetine The metabolism of Sertraline can be decreased when combined with Duloxetine.
Trospium	Trospium Sertraline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan	Bosentan The metabolism of Sertraline can be increased when combined with Bosentan.
Cinacalcet	Cinacalcet The metabolism of Sertraline can be decreased when combined with Cinacalcet.
Erlotinib	Erlotinib The metabolism of Erlotinib can be decreased when combined with Sertraline.
Eszopiclone	Eszopiclone The risk or severity of CNS depression can be increased when Sertraline is combined with Eszopiclone.
Insulin Aspart (rDNA Origin) Injection	Insulin Aspart (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Insulin aspart.
Solifenacin	Solifenacin Sertraline may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Voriconazole	Voriconazole The metabolism of Voriconazole can be decreased when combined with Sertraline.
Dextroamphetamine	Dextroamphetamine The risk or severity of serotonin syndrome can be increased when Amphetamine is combined with Sertraline.
Peginterferon Alfa-2b (PEG-Intron)	Peginterferon Alfa-2b (PEG-Intron) The metabolism of Sertraline can be increased when combined with Peginterferon alfa-2b.
Pramlintide Injection	Pramlintide Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Pramlintide.
Sodium Oxybate	Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Sertraline.
Exenatide Injection	Exenatide Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Exenatide.
Isocarboxazid	Isocarboxazid The risk or severity of serotonin syndrome can be increased when Sertraline is combined with Isocarboxazid.
Ramelteon	Ramelteon The risk or severity of adverse effects can be increased when Ramelteon is combined with Sertraline.
Darifenacin	Darifenacin The metabolism of Darifenacin can be decreased when combined with Sertraline.
Fentanyl	Fentanyl The risk or severity of serotonin syndrome can be increased when Fentanyl is combined with Sertraline.
Pregabalin	Pregabalin The therapeutic efficacy of Sertraline can be increased when used in combination with Pregabalin.
Tipranavir	Tipranavir The metabolism of Tipranavir can be decreased when combined with Sertraline.
Felbamate	Felbamate The risk or severity of adverse effects can be increased when Felbamate is combined with Sertraline.
Insulin Detemir (rDNA Origin) Injection	Insulin Detemir (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Insulin detemir.
Ranolazine	Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Sertraline.
Abatacept Injection	Abatacept Injection The metabolism of Sertraline can be increased when combined with Abatacept.
Rasagiline	Rasagiline The risk or severity of serotonin syndrome can be increased when Rasagiline is combined with Sertraline.
Imatinib	Imatinib The metabolism of Sertraline can be decreased when combined with Imatinib.
Sitagliptin	Sitagliptin The risk or severity of hypoglycemia can be increased when Sertraline is combined with Sitagliptin.
Gefitinib	Gefitinib The metabolism of Sertraline can be decreased when combined with Gefitinib.
Paliperidone	Paliperidone The risk or severity of adverse effects can be increased when Sertraline is combined with Paliperidone.
Bortezomib	Bortezomib The metabolism of Sertraline can be decreased when combined with Bortezomib.
Insulin Glulisine (rDNA origin) Injection	Insulin Glulisine (rDNA origin) Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Insulin glulisine.
Primaquine	Primaquine The metabolism of Primaquine can be decreased when combined with Sertraline.
Darunavir	Darunavir The serum concentration of Sertraline can be decreased when it is combined with Darunavir.
Dimenhydrinate	Dimenhydrinate The risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Sertraline.
Lisdexamfetamine	Lisdexamfetamine The risk or severity of serotonin syndrome can be increased when Sertraline is combined with Lisdexamfetamine.
Nabilone	Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Sertraline.
Sorafenib	Sorafenib The metabolism of Sertraline can be decreased when combined with Sorafenib.
Sunitinib	Sunitinib The risk or severity of hypoglycemia can be increased when Sertraline is combined with Sunitinib.
Dronabinol	Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Sertraline.
Lapatinib	Lapatinib The metabolism of Lapatinib can be decreased when combined with Sertraline.
Levocetirizine	Levocetirizine The risk or severity of adverse effects can be increased when Levocetirizine is combined with Sertraline.
Mexiletine	Mexiletine The metabolism of Mexiletine can be decreased when combined with Sertraline.
Armodafinil	Armodafinil The metabolism of Sertraline can be decreased when combined with Armodafinil.
Temsirolimus	Temsirolimus The metabolism of Sertraline can be decreased when combined with Temsirolimus.
Nilotinib	Nilotinib The metabolism of Nilotinib can be decreased when combined with Sertraline.
Bexarotene	Bexarotene The metabolism of Bexarotene can be decreased when combined with Sertraline.
Chloramphenicol Injection	Chloramphenicol Injection The metabolism of Sertraline can be decreased when combined with Chloramphenicol.
Desmopressin	Desmopressin The risk or severity of hyponatremia can be increased when Sertraline is combined with Desmopressin.
OnabotulinumtoxinA Injection	OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Sertraline.
RimabotulinumtoxinB Injection	RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Sertraline.
Etravirine	Etravirine The metabolism of Etravirine can be decreased when combined with Sertraline.
Desvenlafaxine	Desvenlafaxine The risk or severity of adverse effects can be increased when Sertraline is combined with Desvenlafaxine.
Cevimeline	Cevimeline The metabolism of Cevimeline can be decreased when combined with Sertraline.
Nebivolol	Nebivolol The metabolism of Nebivolol can be decreased when combined with Sertraline.
Tretinoin	Tretinoin The metabolism of Tretinoin can be decreased when combined with Sertraline.
Flecainide	Flecainide The metabolism of Sertraline can be decreased when combined with Flecainide.
Certolizumab Injection	Certolizumab Injection The metabolism of Sertraline can be increased when combined with Certolizumab pegol.
Irinotecan Injection	Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Sertraline.
Praziquantel	Praziquantel The metabolism of Praziquantel can be decreased when combined with Sertraline.
Rufinamide	Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Sertraline.
Midazolam	Midazolam The risk or severity of adverse effects can be increased when Midazolam is combined with Sertraline.
Naltrexone Injection	Naltrexone Injection The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Sertraline.
Milnacipran	Milnacipran The risk or severity of adverse effects can be increased when Sertraline is combined with Milnacipran.
Dexlansoprazole	Dexlansoprazole The metabolism of Dexlansoprazole can be decreased when combined with Sertraline.
Fesoterodine	Fesoterodine Sertraline may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Betaxolol	Betaxolol The serum concentration of Betaxolol can be increased when it is combined with Sertraline.
Iloperidone	Iloperidone The risk or severity of adverse effects can be increased when Sertraline is combined with Iloperidone.
Prasugrel	Prasugrel The risk or severity of bleeding can be increased when Sertraline is combined with Prasugrel.
Lacosamide	Lacosamide The risk or severity of adverse effects can be increased when Lacosamide is combined with Sertraline.
Everolimus	Everolimus The metabolism of Sertraline can be decreased when combined with Everolimus.
Dronedarone	Dronedarone The metabolism of Dronedarone can be decreased when combined with Sertraline.
AbobotulinumtoxinA Injection	AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Sertraline.
Palonosetron Injection	Palonosetron Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Sertraline.
Saxagliptin	Saxagliptin The risk or severity of hypoglycemia can be increased when Sertraline is combined with Saxagliptin.
Romidepsin Injection	Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Sertraline.
Tapentadol	Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Sertraline.
Golimumab Injection	Golimumab Injection The metabolism of Sertraline can be increased when combined with Golimumab.
Pazopanib	Pazopanib The metabolism of Pazopanib can be decreased when combined with Sertraline.
Asenapine	Asenapine The risk or severity of adverse effects can be increased when Sertraline is combined with Asenapine.
Vigabatrin	Vigabatrin The risk or severity of adverse effects can be increased when Vigabatrin is combined with Sertraline.
Pitavastatin	Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Sertraline.
Albendazole	Albendazole The metabolism of Albendazole can be decreased when combined with Sertraline.
Oxymorphone	Oxymorphone The risk or severity of serotonin syndrome can be increased when Oxymorphone is combined with Sertraline.
Dabigatran	Dabigatran The risk or severity of bleeding can be increased when Sertraline is combined with Dabigatran.
Liraglutide Injection	Liraglutide Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Liraglutide.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Sertraline can be increased when combined with Tocilizumab.
Dalfampridine	Dalfampridine The risk or severity of seizure can be increased when Sertraline is combined with Dalfampridine.
IncobotulinumtoxinA Injection	IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Sertraline.
Lurasidone	Lurasidone The risk or severity of adverse effects can be increased when Lurasidone is combined with Sertraline.
Acetaminophen Injection	Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Sertraline.
Vilazodone	Vilazodone The metabolism of Vilazodone can be decreased when combined with Sertraline.
Linagliptin	Linagliptin The risk or severity of hypoglycemia can be increased when Sertraline is combined with Linagliptin.
Rilpivirine	Rilpivirine The metabolism of Sertraline can be decreased when combined with Rilpivirine.
Potassium Iodide	Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Sertraline.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Sertraline.
Abiraterone	Abiraterone The metabolism of Sertraline can be decreased when combined with Abiraterone.
Rivaroxaban	Rivaroxaban The risk or severity of bleeding can be increased when Sertraline is combined with Rivaroxaban.
Ticagrelor	Ticagrelor The risk or severity of bleeding can be increased when Sertraline is combined with Ticagrelor.
Clobazam	Clobazam The metabolism of Sertraline can be decreased when combined with Clobazam.
Vemurafenib	Vemurafenib The metabolism of Sertraline can be decreased when combined with Vemurafenib.
Vismodegib	Vismodegib The metabolism of Vismodegib can be decreased when combined with Sertraline.
Axitinib	Axitinib The metabolism of Axitinib can be decreased when combined with Sertraline.
Cabergoline	Cabergoline The risk or severity of adverse effects can be increased when Cabergoline is combined with Sertraline.
Fondaparinux Injection	Fondaparinux Injection The risk or severity of bleeding can be increased when Sertraline is combined with Fondaparinux.
Ezogabine	Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Sertraline.
Iloprost	Iloprost The risk or severity of bleeding can be increased when Sertraline is combined with Iloprost.
Enzalutamide	Enzalutamide The metabolism of Sertraline can be increased when combined with Enzalutamide.
Mirabegron	Mirabegron The metabolism of Mirabegron can be decreased when combined with Sertraline.
Regorafenib	Regorafenib The metabolism of Sertraline can be decreased when combined with Regorafenib.
Lorcaserin	Lorcaserin The risk or severity of hypoglycemia can be increased when Sertraline is combined with Mecasermin.
Cabozantinib (thyroid cancer)	Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Sertraline.
Icosapent Ethyl	Icosapent Ethyl The risk or severity of bleeding can be increased when Sertraline is combined with Icosapent ethyl.
Alogliptin	Alogliptin The risk or severity of hypoglycemia can be increased when Sertraline is combined with Alogliptin.
Ponatinib	Ponatinib The metabolism of Ponatinib can be decreased when combined with Sertraline.
Pomalidomide	Pomalidomide The risk or severity of adverse effects can be increased when Pomalidomide is combined with Sertraline.
Apixaban	Apixaban The risk or severity of bleeding can be increased when Sertraline is combined with Apixaban.
Canagliflozin	Canagliflozin The risk or severity of hypoglycemia can be increased when Sertraline is combined with Canagliflozin.
Dabrafenib	Dabrafenib The serum concentration of Sertraline can be decreased when it is combined with Dabrafenib.
Ospemifene	Ospemifene The metabolism of Sertraline can be decreased when combined with Ospemifene.
Levomilnacipran	Levomilnacipran The risk or severity of adverse effects can be increased when Sertraline is combined with Levomilnacipran.
Vortioxetine	Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Sertraline.
Perampanel	Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Sertraline.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Sertraline.
Ketorolac Injection	Ketorolac Injection The risk or severity of bleeding can be increased when Sertraline is combined with Ketorolac.
Dapagliflozin	Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Sertraline.
Apremilast	Apremilast The metabolism of Sertraline can be increased when combined with Apremilast.
Ceritinib	Ceritinib The metabolism of Sertraline can be decreased when combined with Ceritinib.
Siltuximab Injection	Siltuximab Injection The metabolism of Sertraline can be increased when combined with Siltuximab.
Albiglutide Injection	Albiglutide Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Albiglutide.
Eslicarbazepine	Eslicarbazepine The risk or severity of adverse effects can be increased when Eslicarbazepine is combined with Sertraline.
Testosterone Injection	Testosterone Injection The metabolism of Testosterone can be decreased when combined with Sertraline.
Oritavancin Injection	Oritavancin Injection The metabolism of Sertraline can be decreased when combined with Oritavancin.
Empagliflozin	Empagliflozin The risk or severity of hypoglycemia can be increased when Sertraline is combined with Empagliflozin.
Vorapaxar	Vorapaxar The risk or severity of bleeding can be increased when Sertraline is combined with Vorapaxar.
Hydrocodone	Hydrocodone Sertraline may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Suvorexant	Suvorexant Sertraline may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Dulaglutide Injection	Dulaglutide Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Dulaglutide.
Edoxaban	Edoxaban The risk or severity of bleeding can be increased when Sertraline is combined with Edoxaban.
Methamphetamine	Methamphetamine The risk or severity of adverse effects can be increased when Metamfetamine is combined with Sertraline.
Tasimelteon	Tasimelteon The risk or severity of adverse effects can be increased when Tasimelteon is combined with Sertraline.
Lanreotide Injection	Lanreotide Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Lanreotide.
Secukinumab Injection	Secukinumab Injection The metabolism of Sertraline can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection The risk or severity of adverse effects can be increased when Risperidone is combined with Sertraline.
Insulin Human Inhalation	Insulin Human Inhalation The risk or severity of hypoglycemia can be increased when Insulin human is combined with Sertraline.
Lenvatinib	Lenvatinib The metabolism of Sertraline can be decreased when combined with Lenvatinib.
Naloxegol	Naloxegol The metabolism of Sertraline can be decreased when combined with Naloxegol.
Panobinostat	Panobinostat The metabolism of Panobinostat can be decreased when combined with Sertraline.
Haloperidol Injection	Haloperidol Injection The risk or severity of QTc prolongation can be increased when Haloperidol is combined with Sertraline.
Flibanserin	Flibanserin The risk or severity of adverse effects can be increased when Flibanserin is combined with Sertraline.
Rolapitant	Rolapitant The metabolism of Rolapitant can be decreased when combined with Sertraline.
Brexpiprazole	Brexpiprazole The risk or severity of adverse effects can be increased when Sertraline is combined with Brexpiprazole.
Ziprasidone Injection	Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Ziprasidone is combined with Sertraline.
Cariprazine	Cariprazine The risk or severity of adverse effects can be increased when Sertraline is combined with Cariprazine.
Eluxadoline	Eluxadoline The risk or severity of serotonin syndrome can be increased when Sertraline is combined with Eluxadoline.
Insulin Degludec (rDNA Origin) Injection	Insulin Degludec (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Insulin degludec.
Trabectedin Injection	Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Sertraline.
Rifapentine	Rifapentine The metabolism of Sertraline can be increased when combined with Rifapentine.
Lesinurad	Lesinurad The metabolism of Lesinurad can be decreased when combined with Sertraline.
Defibrotide Injection	Defibrotide Injection The risk or severity of bleeding can be increased when Sertraline is combined with Defibrotide.
Brivaracetam Injection	Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Sertraline.
Cobicistat	Cobicistat The metabolism of Sertraline can be decreased when combined with Cobicistat.
Pimavanserin	Pimavanserin The risk or severity of adverse effects can be increased when Sertraline is combined with Pimavanserin.
Diphenhydramine Injection	Diphenhydramine Injection The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Sertraline.
Rucaparib	Rucaparib The metabolism of Sertraline can be decreased when combined with Rucaparib.
Lixisenatide Injection	Lixisenatide Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Lixisenatide.
Parathyroid Hormone Injection	Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Sertraline.
Doxepin (Insomnia)	Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Sertraline.
Deutetrabenazine	Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Sertraline.
Valbenazine	Valbenazine The metabolism of Valbenazine can be decreased when combined with Sertraline.
Safinamide	Safinamide The risk or severity of serotonin syndrome can be increased when Safinamide is combined with Sertraline.
Midostaurin	Midostaurin The metabolism of Sertraline can be decreased when combined with Midostaurin.
Abaloparatide Injection	Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Sertraline.
Enasidenib	Enasidenib The metabolism of Sertraline can be decreased when combined with Enasidenib.
Delafloxacin	Delafloxacin The metabolism of Sertraline can be increased when combined with Delafloxacin.
Betrixaban	Betrixaban The risk or severity of bleeding can be increased when Sertraline is combined with Betrixaban.
Letermovir	Letermovir The metabolism of Sertraline can be increased when combined with Letermovir.
Semaglutide Injection	Semaglutide Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Semaglutide.
Tetrabenazine	Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Sertraline.
Ertugliflozin	Ertugliflozin The risk or severity of hypoglycemia can be increased when Sertraline is combined with Ertugliflozin.
Buprenorphine Injection	Buprenorphine Injection Sertraline may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide	Apalutamide The serum concentration of Sertraline can be increased when it is combined with Apalutamide.
Avatrombopag	Avatrombopag The metabolism of Sertraline can be increased when combined with Avatrombopag.
Lofexidine	Lofexidine The therapeutic efficacy of Sertraline can be increased when used in combination with Lofexidine.
Eliglustat	Eliglustat The metabolism of Sertraline can be decreased when combined with Eliglustat.
Encorafenib	Encorafenib The metabolism of Encorafenib can be decreased when combined with Sertraline.
Elagolix	Elagolix The metabolism of Elagolix can be decreased when combined with Sertraline.
Tafenoquine	Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Sertraline.
Cannabidiol	Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Sertraline.
Dacomitinib	Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Sertraline.
Stiripentol	Stiripentol The metabolism of Sertraline can be decreased when combined with Stiripentol.
Gilteritinib	Gilteritinib The therapeutic efficacy of Sertraline can be decreased when used in combination with Gilteritinib.
Lorlatinib	Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Sertraline.
Rifamycin	Rifamycin The metabolism of Rifamycin can be increased when combined with Sertraline.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Sertraline can be increased when combined with Emapalumab.
Siponimod	Siponimod The metabolism of Siponimod can be decreased when combined with Sertraline.
Caplacizumab-yhdp Injection	Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Sertraline is combined with Caplacizumab.
Erdafitinib	Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Sertraline.
Esomeprazole Injection	Esomeprazole Injection The metabolism of Sertraline can be decreased when combined with Esomeprazole.
Alpelisib	Alpelisib The serum concentration of Sertraline can be decreased when it is combined with Alpelisib.
Brexanolone Injection	Brexanolone Injection The risk or severity of adverse effects can be increased when Brexanolone is combined with Sertraline.
Solriamfetol	Solriamfetol The risk or severity of adverse effects can be increased when Solriamfetol is combined with Sertraline.
Triclabendazole	Triclabendazole The metabolism of Triclabendazole can be decreased when combined with Sertraline.
Entrectinib	Entrectinib The risk or severity of QTc prolongation can be increased when Sertraline is combined with Entrectinib.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Sertraline.
Pitolisant	Pitolisant The serum concentration of Sertraline can be decreased when it is combined with Pitolisant.
Fedratinib	Fedratinib The metabolism of Fedratinib can be decreased when combined with Sertraline.
Lefamulin	Lefamulin Sertraline may increase the QTc-prolonging activities of Lefamulin.
Phenytoin Injection	Phenytoin Injection The serum concentration of Phenytoin can be increased when it is combined with Sertraline.
Fosphenytoin Injection	Fosphenytoin Injection The serum concentration of Fosphenytoin can be increased when it is combined with Sertraline.
Zanubrutinib	Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Sertraline.
Voxelotor	Voxelotor The metabolism of Voxelotor can be decreased when combined with Sertraline.
Avapritinib	Avapritinib The metabolism of Avapritinib can be decreased when combined with Sertraline.
Lumateperone	Lumateperone The risk or severity of adverse effects can be increased when Lumateperone is combined with Sertraline.
Lasmiditan	Lasmiditan The risk or severity of serotonin syndrome can be increased when Lasmiditan is combined with Sertraline.
Cenobamate	Cenobamate The serum concentration of Cenobamate can be decreased when it is combined with Sertraline.
Selumetinib	Selumetinib The metabolism of Selumetinib can be decreased when combined with Sertraline.
Tucatinib	Tucatinib The metabolism of Tucatinib can be decreased when combined with Sertraline.
Lemborexant	Lemborexant The risk or severity of adverse effects can be increased when Lemborexant is combined with Sertraline.
Fenfluramine	Fenfluramine The risk or severity of serotonin syndrome can be increased when Fenfluramine is combined with Sertraline.
Octreotide	Octreotide The risk or severity of hypoglycemia can be increased when Octreotide is combined with Sertraline.
Pralsetinib	Pralsetinib The metabolism of Sertraline can be decreased when combined with Pralsetinib.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Sertraline can be decreased when it is combined with Satralizumab.
Viloxazine	Viloxazine The risk or severity of adverse effects can be increased when Sertraline is combined with Viloxazine.
Theophylline	Theophylline The metabolism of Theophylline can be decreased when combined with Sertraline.
Fenoprofen	Fenoprofen The risk or severity of bleeding can be increased when Sertraline is combined with Fenoprofen.
Indomethacin	Indomethacin The risk or severity of bleeding can be increased when Sertraline is combined with Indomethacin.
Mefenamic Acid	Mefenamic Acid The risk or severity of bleeding can be increased when Sertraline is combined with Mefenamic acid.
Naproxen	Naproxen The risk or severity of bleeding can be increased when Sertraline is combined with Naproxen.
Tolmetin	Tolmetin The risk or severity of bleeding can be increased when Sertraline is combined with Tolmetin.
Sulindac	Sulindac The risk or severity of bleeding can be increased when Sertraline is combined with Sulindac.
Trazodone	Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Sertraline.
Hydroxyurea	Hydroxyurea The metabolism of Sertraline can be decreased when combined with Hydroxyurea.
Floxuridine	Floxuridine The metabolism of Sertraline can be decreased when combined with Floxuridine.
Phenobarbital	Phenobarbital The metabolism of Sertraline can be decreased when combined with Phenobarbital.
Metaxalone	Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Sertraline.
Levorphanol	Levorphanol The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Sertraline.
Primidone	Primidone The risk or severity of adverse effects can be increased when Primidone is combined with Sertraline.
Methsuximide	Methsuximide The risk or severity of adverse effects can be increased when Methsuximide is combined with Sertraline.
Diethylpropion	Diethylpropion The risk or severity of adverse effects can be increased when Diethylpropion is combined with Sertraline.
Chlorpromazine	Chlorpromazine The metabolism of Sertraline can be decreased when combined with Chlorpromazine.
Diazepam	Diazepam The risk or severity of adverse effects can be increased when Diazepam is combined with Sertraline.
Oxazepam	Oxazepam The risk or severity of adverse effects can be increased when Oxazepam is combined with Sertraline.
Flurazepam	Flurazepam The risk or severity of adverse effects can be increased when Flurazepam is combined with Sertraline.
Clorazepate	Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Sertraline.
Lorazepam	Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Sertraline.
Amantadine	Amantadine The risk or severity of serotonin syndrome can be increased when Amantadine is combined with Sertraline.
Codeine	Codeine The risk or severity of serotonin syndrome can be increased when Codeine is combined with Sertraline.
Meprobamate	Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Sertraline.
Chlordiazepoxide	Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Sertraline.
Bromocriptine	Bromocriptine The risk or severity of adverse effects can be increased when Bromocriptine is combined with Sertraline.
Tranylcypromine	Tranylcypromine The risk or severity of serotonin syndrome can be increased when Tranylcypromine is combined with Sertraline.
Phenelzine	Phenelzine The risk or severity of serotonin syndrome can be increased when Phenelzine is combined with Sertraline.
Procarbazine	Procarbazine The risk or severity of serotonin syndrome can be increased when Procarbazine is combined with Sertraline.
Ergoloid Mesylates	Ergoloid Mesylates The risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Sertraline.
Minocycline	Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Sertraline.
Prochlorperazine	Prochlorperazine The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Sertraline.
Thioridazine	Thioridazine The metabolism of Sertraline can be decreased when combined with Thioridazine.
Trifluoperazine	Trifluoperazine The risk or severity of adverse effects can be increased when Trifluoperazine is combined with Sertraline.
Dapsone	Dapsone The metabolism of Dapsone can be decreased when combined with Sertraline.
Sulfadiazine	Sulfadiazine The metabolism of Sertraline can be decreased when combined with Sulfadiazine.
Oxycodone	Oxycodone The risk or severity of serotonin syndrome can be increased when Oxycodone is combined with Sertraline.
Methadone	Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Sertraline.
Oxybutynin	Oxybutynin The metabolism of Sertraline can be decreased when combined with Oxybutynin.
Benztropine	Benztropine Sertraline may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
Maprotiline	Maprotiline The risk or severity of adverse effects can be increased when Maprotiline is combined with Sertraline.
Ibuprofen	Ibuprofen The risk or severity of bleeding can be increased when Sertraline is combined with Ibuprofen.
Trihexyphenidyl	Trihexyphenidyl Sertraline may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine	Orphenadrine Sertraline may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine	Perphenazine The risk or severity of adverse effects can be increased when Perphenazine is combined with Sertraline.
Fluphenazine	Fluphenazine The risk or severity of adverse effects can be increased when Fluphenazine is combined with Sertraline.
Phentermine	Phentermine The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Sertraline.
Amoxapine	Amoxapine The metabolism of Sertraline can be decreased when combined with Amoxapine.
Sulfasalazine	Sulfasalazine The risk or severity of bleeding can be increased when Sertraline is combined with Sulfasalazine.
Doxorubicin	Doxorubicin The metabolism of Sertraline can be decreased when combined with Doxorubicin.
Carbamazepine	Carbamazepine The risk or severity of adverse effects can be increased when Carbamazepine is combined with Sertraline.
Molindone	Molindone The risk or severity of adverse effects can be increased when Sertraline is combined with Molindone.
Clonidine	Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Sertraline.
Cimetidine	Cimetidine The metabolism of Cimetidine can be decreased when combined with Sertraline.
Warfarin	Warfarin The risk or severity of bleeding can be increased when Sertraline is combined with Warfarin.
Clonazepam	Clonazepam The risk or severity of adverse effects can be increased when Clonazepam is combined with Sertraline.
Loperamide	Loperamide The metabolism of Loperamide can be decreased when combined with Sertraline.
Promethazine	Promethazine The metabolism of Sertraline can be decreased when combined with Promethazine.
Meclofenamate	Meclofenamate The risk or severity of bleeding can be increased when Sertraline is combined with Meclofenamic acid.
Loxapine	Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Sertraline.
Chloroquine	Chloroquine The metabolism of Chloroquine can be decreased when combined with Sertraline.
Quinine	Quinine The metabolism of Quinine can be decreased when combined with Sertraline.
Ethosuximide	Ethosuximide The therapeutic efficacy of Ethosuximide can be decreased when used in combination with Sertraline.
Sulfinpyrazone	Sulfinpyrazone The risk or severity of bleeding can be increased when Sulfinpyrazone is combined with Sertraline.
Chlorothiazide	Chlorothiazide The risk or severity of hyponatremia can be increased when Sertraline is combined with Chlorothiazide.
Chlorthalidone	Chlorthalidone The risk or severity of hyponatremia can be increased when Sertraline is combined with Chlorthalidone.
Metolazone	Metolazone The risk or severity of hyponatremia can be increased when Sertraline is combined with Metolazone.
Secobarbital	Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Sertraline.
Desipramine	Desipramine The metabolism of Desipramine can be decreased when combined with Sertraline.
Amitriptyline	Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Sertraline.
Imipramine	Imipramine The metabolism of Sertraline can be decreased when combined with Imipramine.
Probenecid	Probenecid The metabolism of Sertraline can be decreased when combined with Probenecid.
Quinidine	Quinidine The metabolism of Quinidine can be decreased when combined with Sertraline.
Procainamide	Procainamide The metabolism of Procainamide can be decreased when combined with Sertraline.
Isoniazid	Isoniazid The metabolism of Sertraline can be decreased when combined with Isoniazid.
Rifampin	Rifampin The metabolism of Sertraline can be increased when combined with Rifampicin.
Disopyramide	Disopyramide Sertraline may increase the central nervous system depressant (CNS depressant) activities of Disopyramide.
Valproic Acid	Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Sertraline.
Tamoxifen	Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Sertraline.
Butabarbital	Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Sertraline.
Levothyroxine	Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Sertraline.
Liothyronine	Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Sertraline.
Methimazole	Methimazole The metabolism of Methimazole can be decreased when combined with Sertraline.
Propylthiouracil	Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Sertraline.
Chlorpropamide	Chlorpropamide The metabolism of Chlorpropamide can be decreased when combined with Sertraline.
Tolbutamide	Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Sertraline.
Tolazamide	Tolazamide The metabolism of Tolazamide can be decreased when combined with Sertraline.
Dextromethorphan	Dextromethorphan The risk or severity of adverse effects can be increased when Sertraline is combined with Dextromethorphan.
Cyclobenzaprine	Cyclobenzaprine The risk or severity of CNS depression can be increased when Sertraline is combined with Cyclobenzaprine.
Niacin	Niacin The metabolism of Sertraline can be decreased when combined with Niacin.
Baclofen	Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Sertraline.
Doxylamine	Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Sertraline.
Cyproheptadine	Cyproheptadine The therapeutic efficacy of Sertraline can be decreased when used in combination with Cyproheptadine.
Clemastine	Clemastine The risk or severity of adverse effects can be increased when Sertraline is combined with Clemastine.
Chlorpheniramine	Chlorpheniramine The risk or severity of adverse effects can be increased when Chlorpheniramine is combined with Sertraline.
Brompheniramine	Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Sertraline.
Meclizine	Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Sertraline.
Methyclothiazide	Methyclothiazide The risk or severity of hyponatremia can be increased when Sertraline is combined with Methyclothiazide.
Hydrochlorothiazide	Hydrochlorothiazide The risk or severity of hyponatremia can be increased when Sertraline is combined with Hydrochlorothiazide.
Dantrolene	Dantrolene The risk or severity of adverse effects can be increased when Dantrolene is combined with Sertraline.
Chlorzoxazone	Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Sertraline.
Carisoprodol	Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Sertraline.
Methocarbamol	Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Sertraline.
Disulfiram	Disulfiram The risk or severity of adverse effects can be increased when Disulfiram is combined with Sertraline.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The serum concentration of Propranolol can be increased when it is combined with Sertraline.
Pseudoephedrine	Pseudoephedrine The risk or severity of serotonin syndrome can be increased when Pseudoephedrine is combined with Sertraline.
Nortriptyline	Nortriptyline The metabolism of Sertraline can be decreased when combined with Nortriptyline.
Nadolol	Nadolol The serum concentration of Nadolol can be increased when it is combined with Sertraline.
Butorphanol Injection	Butorphanol Injection The risk or severity of serotonin syndrome can be increased when Butorphanol is combined with Sertraline.
Nalbuphine Injection	Nalbuphine Injection The risk or severity of serotonin syndrome can be increased when Nalbuphine is combined with Sertraline.
Trimethobenzamide	Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Sertraline.
Flavoxate	Flavoxate Sertraline may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Fluorouracil Injection	Fluorouracil Injection The metabolism of Sertraline can be decreased when combined with Fluorouracil.
Acetazolamide	Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Sertraline.
Calcitonin Salmon Injection	Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Sertraline.
Ketoconazole	Ketoconazole The metabolism of Sertraline can be decreased when combined with Ketoconazole.
Pyrantel	Pyrantel The risk or severity of adverse effects can be increased when Pyrantel is combined with Sertraline.
Dipyridamole	Dipyridamole The risk or severity of bleeding can be increased when Sertraline is combined with Dipyridamole.
Vinblastine	Vinblastine The metabolism of Sertraline can be decreased when combined with Vinblastine.
Metoprolol	Metoprolol The metabolism of Metoprolol can be decreased when combined with Sertraline.
Hydroxyzine	Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Sertraline.
Thiothixene	Thiothixene The risk or severity of adverse effects can be increased when Sertraline is combined with Thiothixene.
Aspirin	Aspirin The risk or severity of bleeding can be increased when Sertraline is combined with Acetylsalicylic acid.
Salsalate	Salsalate The risk or severity of bleeding can be increased when Sertraline is combined with Salsalate.
Alprazolam	Alprazolam The risk or severity of adverse effects can be increased when Alprazolam is combined with Sertraline.
Temazepam	Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Sertraline.
Triazolam	Triazolam The risk or severity of adverse effects can be increased when Triazolam is combined with Sertraline.
Dicyclomine	Dicyclomine Sertraline may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine	Hyoscyamine Sertraline may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline	Propantheline Sertraline may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Trimethoprim	Trimethoprim The metabolism of Trimethoprim can be decreased when combined with Sertraline.
Diltiazem	Diltiazem The metabolism of Diltiazem can be decreased when combined with Sertraline.
Nifedipine	Nifedipine The metabolism of Sertraline can be decreased when combined with Nifedipine.
Timolol	Timolol The metabolism of Timolol can be decreased when combined with Sertraline.
Verapamil	Verapamil The metabolism of Verapamil can be decreased when combined with Sertraline.
Atenolol	Atenolol The serum concentration of Atenolol can be increased when it is combined with Sertraline.
Pindolol	Pindolol The risk or severity of adverse effects can be increased when Pindolol is combined with Sertraline.
Cisplatin Injection	Cisplatin Injection The metabolism of Sertraline can be decreased when combined with Cisplatin.
Diflunisal	Diflunisal The risk or severity of bleeding can be increased when Sertraline is combined with Diflunisal.
Piroxicam	Piroxicam The risk or severity of bleeding can be increased when Sertraline is combined with Piroxicam.
Glyburide	Glyburide The metabolism of Sertraline can be decreased when combined with Glyburide.
Glipizide	Glipizide The metabolism of Glipizide can be decreased when combined with Sertraline.
Indapamide	Indapamide The risk or severity of hyponatremia can be increased when Sertraline is combined with Indapamide.
Pentoxifylline	Pentoxifylline The risk or severity of bleeding can be increased when Sertraline is combined with Pentoxifylline.
Pentamidine Injection	Pentamidine Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Pentamidine.
Labetalol	Labetalol The metabolism of Labetalol can be decreased when combined with Sertraline.
Gemfibrozil	Gemfibrozil The metabolism of Sertraline can be decreased when combined with Gemfibrozil.
Ketoprofen	Ketoprofen The risk or severity of bleeding can be increased when Ketoprofen is combined with Sertraline.
Pimozide	Pimozide Sertraline may increase the arrhythmogenic activities of Pimozide.
Flurbiprofen	Flurbiprofen The risk or severity of bleeding can be increased when Sertraline is combined with Flurbiprofen.
Amiodarone	Amiodarone The metabolism of Sertraline can be decreased when combined with Amiodarone.
Buspirone	Buspirone The risk or severity of serotonin syndrome can be increased when Sertraline is combined with Buspirone.
Lovastatin	Lovastatin The metabolism of Sertraline can be decreased when combined with Lovastatin.
Mesalamine	Mesalamine The risk or severity of bleeding can be increased when Sertraline is combined with Mesalazine.
Diclofenac	Diclofenac The risk or severity of bleeding can be increased when Sertraline is combined with Diclofenac.
Fluoxetine	Fluoxetine The serum concentration of Sertraline can be increased when it is combined with Fluoxetine.
Clozapine	Clozapine The metabolism of Sertraline can be decreased when combined with Clozapine.
Estazolam	Estazolam The risk or severity of adverse effects can be increased when Sertraline is combined with Estazolam.
Idarubicin	Idarubicin The metabolism of Idarubicin can be decreased when combined with Sertraline.
Etodolac	Etodolac The risk or severity of bleeding can be increased when Sertraline is combined with Etodolac.
Felodipine	Felodipine The metabolism of Sertraline can be decreased when combined with Felodipine.
Nabumetone	Nabumetone The risk or severity of bleeding can be increased when Sertraline is combined with Nabumetone.
Simvastatin	Simvastatin The metabolism of Simvastatin can be decreased when combined with Sertraline.
Teniposide Injection	Teniposide Injection The metabolism of Sertraline can be decreased when combined with Teniposide.
Oxaprozin	Oxaprozin The risk or severity of bleeding can be increased when Sertraline is combined with Oxaprozin.
Atovaquone	Atovaquone The metabolism of Sertraline can be decreased when combined with Atovaquone.
Rifabutin	Rifabutin The metabolism of Sertraline can be increased when combined with Rifabutin.
Sotalol	Sotalol The metabolism of Sotalol can be decreased when combined with Sertraline.
Bisoprolol	Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Sertraline.
Zolpidem	Zolpidem Sertraline may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin	Doxazosin The metabolism of Doxazosin can be decreased when combined with Sertraline.
Omeprazole	Omeprazole The metabolism of Omeprazole can be decreased when combined with Sertraline.
Cisapride	Cisapride The metabolism of Cisapride can be decreased when combined with Sertraline.
Gabapentin	Gabapentin The risk or severity of adverse effects can be increased when Gabapentin is combined with Sertraline.
Fluvastatin	Fluvastatin The metabolism of Sertraline can be decreased when combined with Fluvastatin.
Venlafaxine	Venlafaxine The metabolism of Sertraline can be decreased when combined with Venlafaxine.
Fluvoxamine	Fluvoxamine The metabolism of Sertraline can be decreased when combined with Fluvoxamine.
Nefazodone	Nefazodone The risk or severity of adverse effects can be increased when Sertraline is combined with Nefazodone.
Lamotrigine	Lamotrigine The risk or severity of adverse effects can be increased when Lamotrigine is combined with Sertraline.
Losartan	Losartan The metabolism of Losartan can be decreased when combined with Sertraline.
Tramadol	Tramadol The risk or severity of serotonin syndrome can be increased when Sertraline is combined with Tramadol.
Vinorelbine Injection	Vinorelbine Injection The metabolism of Sertraline can be decreased when combined with Vinorelbine.
Lansoprazole	Lansoprazole The metabolism of Lansoprazole can be decreased when combined with Sertraline.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Sertraline.
Nicardipine	Nicardipine The metabolism of Sertraline can be decreased when combined with Nicardipine.
Bupropion	Bupropion The risk or severity of seizure can be increased when Sertraline is combined with Bupropion.
Ticlopidine	Ticlopidine The risk or severity of bleeding can be increased when Ticlopidine is combined with Sertraline.
Saquinavir	Saquinavir The metabolism of Sertraline can be decreased when combined with Saquinavir.
Metformin	Metformin The risk or severity of hypoglycemia can be increased when Sertraline is combined with Metformin.
Dalteparin Injection	Dalteparin Injection The risk or severity of bleeding can be increased when Sertraline is combined with Dalteparin.
Riluzole	Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Sertraline.
Acarbose	Acarbose The risk or severity of hypoglycemia can be increased when Acarbose is combined with Sertraline.
Glimepiride	Glimepiride The metabolism of Glimepiride can be decreased when combined with Sertraline.
Ritonavir	Ritonavir The serum concentration of Sertraline can be increased when it is combined with Ritonavir.
Clomipramine	Clomipramine The metabolism of Sertraline can be decreased when combined with Clomipramine.
Zafirlukast	Zafirlukast The metabolism of Sertraline can be decreased when combined with Zafirlukast.
Mirtazapine	Mirtazapine Sertraline may increase the serotonergic activities of Mirtazapine.
Topiramate	Topiramate The risk or severity of adverse effects can be increased when Sertraline is combined with Topiramate.
Zileuton	Zileuton The metabolism of Zileuton can be decreased when combined with Sertraline.
Valsartan	Valsartan The metabolism of Sertraline can be decreased when combined with Valsartan.
Insulin Lispro Injection	Insulin Lispro Injection The risk or severity of hypoglycemia can be increased when Insulin lispro is combined with Sertraline.
Pramipexole	Pramipexole Sertraline may increase the sedative activities of Pramipexole.
Donepezil	Donepezil The risk or severity of adverse effects can be increased when Donepezil is combined with Sertraline.
Nelfinavir	Nelfinavir The metabolism of Sertraline can be decreased when combined with Nelfinavir.
Carvedilol	Carvedilol The metabolism of Carvedilol can be decreased when combined with Sertraline.
Nilutamide	Nilutamide The metabolism of Sertraline can be decreased when combined with Nilutamide.
Selegiline	Selegiline The risk or severity of serotonin syndrome can be increased when Selegiline is combined with Sertraline.
Bicalutamide	Bicalutamide The metabolism of Sertraline can be decreased when combined with Bicalutamide.
Propafenone	Propafenone Sertraline may increase the QTc-prolonging activities of Propafenone.
Letrozole	Letrozole The metabolism of Sertraline can be decreased when combined with Letrozole.
Irbesartan	Irbesartan The metabolism of Irbesartan can be decreased when combined with Sertraline.
Tamsulosin	Tamsulosin The metabolism of Tamsulosin can be decreased when combined with Sertraline.
Ropinirole	Ropinirole Sertraline may increase the sedative activities of Ropinirole.
Quetiapine	Quetiapine The risk or severity of adverse effects can be increased when Sertraline is combined with Quetiapine.
Cetirizine	Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Sertraline.
Paroxetine	Paroxetine The metabolism of Sertraline can be decreased when combined with Paroxetine.
Tolcapone	Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Sertraline.
Citalopram	Citalopram The serum concentration of Citalopram can be increased when it is combined with Sertraline.
Capecitabine	Capecitabine The metabolism of Sertraline can be decreased when combined with Capecitabine.
Efavirenz	Efavirenz The serum concentration of Sertraline can be decreased when it is combined with Efavirenz.
Sildenafil	Sildenafil The metabolism of Sertraline can be decreased when combined with Sildenafil.
Pioglitazone	Pioglitazone The risk or severity of hypoglycemia can be increased when Sertraline is combined with Pioglitazone.
Celecoxib	Celecoxib The risk or severity of bleeding can be increased when Celecoxib is combined with Sertraline.
Rosiglitazone	Rosiglitazone The metabolism of Rosiglitazone can be decreased when combined with Sertraline.
Tolterodine	Tolterodine The metabolism of Tolterodine can be decreased when combined with Sertraline.
Thalidomide	Thalidomide Sertraline may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Balsalazide	Balsalazide The risk or severity of bleeding can be increased when Sertraline is combined with Balsalazide.
Nateglinide	Nateglinide The metabolism of Nateglinide can be decreased when combined with Sertraline.
Galantamine	Galantamine The metabolism of Galantamine can be decreased when combined with Sertraline.
Levetiracetam	Levetiracetam The risk or severity of adverse effects can be increased when Levetiracetam is combined with Sertraline.
Rabeprazole	Rabeprazole The metabolism of Sertraline can be decreased when combined with Rabeprazole.
Terbinafine	Terbinafine The metabolism of Sertraline can be decreased when combined with Terbinafine.