Sertraline
Sertraline is an SSRI antidepressant used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, social anxiety disorder, and premenstrual dysphoric disorder — with specific approvals varying by product and formulation.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 184 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾
Sertraline and other antidepressants can increase the risk of suicidal thoughts and behaviors in children, teenagers, and young adults under 25. This risk was seen in short-term studies of people being treated for depression and other psychiatric conditions. It is highest in the first few weeks of treatment and around the time of any dose change. Adults older than 24 did not show this increased risk, and in adults 65 and older, antidepressants were associated with a reduced risk of suicidality compared to placebo. Watch closely for warning signs — worsening depression, unusual changes in behavior, agitation, or any talk or actions involving self-harm — and contact the prescriber immediately if these appear. Families and caregivers should be actively involved in watching for these changes. Sertraline tablets are only approved for use in children for OCD, not for depression.
📖 Sertraline: Patient Information Guide
A plain-language walkthrough of Sertraline — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.
🎯What it's used for▾
Sertraline is an SSRI approved to treat several psychiatric conditions — though which conditions are covered depends on the specific product and formulation.
- All sertraline formulations: Major depressive disorder (MDD) in adults
- All sertraline formulations: Obsessive-compulsive disorder (OCD) in adults
- Oral solution (including Zoloft), several tablet formulations, and film-coated tablets: Panic disorder (PD), post-traumatic stress disorder (PTSD), social anxiety disorder (SAD), and premenstrual dysphoric disorder (PMDD)
- Sertraline HCl capsules and sertraline hydrochloride tablets: OCD in pediatric patients aged 6 and older
- Sertraline HCl capsules: Approved for MDD in adults and OCD in adults and pediatric patients 6 years and older; only available in higher dose strengths — not for starting treatment
- Sertraline is not approved for MDD in pediatric patients in any formulation
⚙️How it works▾
Sertraline is a selective serotonin reuptake inhibitor (SSRI). It works by blocking the reabsorption of serotonin — a chemical messenger involved in mood, anxiety, and behavior — back into the nerve cells that released it. By keeping more serotonin active between nerve cells, sertraline helps regulate mood and ease symptoms of depression, anxiety, and obsessive thinking over time.
Sertraline is highly selective: it has very little effect on other brain chemicals like norepinephrine or dopamine, and it doesn't significantly interact with receptors linked to sedation, anticholinergic effects (like dry mouth and constipation from older antidepressants), or cardiovascular effects. It does not inhibit monoamine oxidase (MAO), which is important because combining it with MAOI drugs is dangerous.
💊How it's taken▾
Sertraline is taken orally once a day. Tablets and film-coated tablets may be taken with or without food — though food increases absorption slightly. The oral solution must always be diluted in water, ginger ale, lemon or lime soda, lemonade, or orange juice before drinking; never take it undiluted. Capsules must be swallowed whole — do not open, crush, or chew them.
- Sertraline HCl capsules are only available in higher dose strengths and cannot be used to start treatment — another sertraline product must be used first for initial dosing and dose increases
- Dose changes should be spaced at least one week apart to allow the body to adjust
- When stopping, the dose should always be reduced gradually — ask your doctor for a tapering plan
- Follow your prescriber's exact instructions; the right dose and schedule depend on your condition and individual response
🤒Side effects — in detail▾
The most common side effects with sertraline — seen in at least 5% of patients and more than twice as often as with placebo — include:
- Nausea
- Diarrhea or loose stools
- Insomnia
- Dizziness
- Tremor (shaking)
- Sweating more than usual
- Decreased appetite
- Fatigue
- Dry mouth
- Sexual side effects (decreased sex drive, ejaculation problems, erectile dysfunction)
- In children: fever, weight loss, hyperactivity, urinary incontinence, and anxiety have also been reported
More serious reactions — including serotonin syndrome, significant bleeding, mania, seizures, low sodium levels, and angle-closure glaucoma — require immediate medical attention. Stopping sertraline suddenly can cause a discontinuation syndrome (withdrawal-like symptoms), so always taper off gradually under your doctor's guidance.
⚠️Warnings & precautions▾
- Suicidal thoughts in young people: Sertraline and other antidepressants increase the risk of suicidal thinking and behavior in children, teens, and adults under 25, especially early in treatment or after dose changes. Watch closely and report any warning signs to the prescriber immediately.
- Serotonin syndrome: Taking sertraline with other serotonin-boosting medications (other SSRIs, SNRIs, triptans, MAOIs) can cause a dangerous buildup of serotonin — symptoms include agitation, rapid heart rate, muscle twitching, high fever, and confusion. Seek emergency care immediately.
- Increased bleeding risk: Sertraline affects platelet function; bleeding risk goes up further when combined with blood thinners, aspirin, or NSAIDs.
- Manic episodes: Sertraline can trigger mania or hypomania (abnormally elevated mood, racing thoughts, decreased need for sleep) — especially in people with undiagnosed bipolar disorder. Screen for bipolar disorder before starting.
- QTc prolongation: Sertraline can slightly lengthen the QT interval (a measure of heart electrical activity); the oral solution should be used with caution in patients at risk for this. Avoid combining with pimozide.
- Hyponatremia (low blood sodium): Rare but serious — watch for headache, confusion, weakness, or seizures, especially in older adults.
- Angle-closure glaucoma: Sertraline can dilate the pupil and may trigger acute glaucoma in people with narrow eye angles. Avoid in patients with untreated narrow-angle anatomy.
- Discontinuation syndrome: Always taper off gradually — stopping suddenly can cause uncomfortable withdrawal-like symptoms.
🔀What it interacts with▾
Sertraline interacts with several medications and substances — some combinations are dangerous and must be avoided:
- MAOIs (e.g., linezolid, methylene blue IV, phenelzine, selegiline): Combining with sertraline — or using within 14 days of each other — can cause fatal serotonin syndrome. This is an absolute contraindication.
- Pimozide: Must never be taken with sertraline — serious heart rhythm problems can result.
- Disulfiram (with the oral solution only): The oral solution contains alcohol; using it with disulfiram can cause a severe reaction.
- Warfarin and other blood thinners: Sertraline can increase prothrombin time (a measure of clotting); bleeding risk rises. Monitor closely.
- Aspirin and NSAIDs (e.g., ibuprofen, naproxen): Combined use raises the risk of bleeding.
- Other serotonergic drugs (SSRIs, SNRIs, triptans): Increases the risk of serotonin syndrome.
- Highly protein-bound drugs (e.g., digitoxin, propranolol): Sertraline is 98% protein-bound and may compete with or displace other protein-bound drugs, potentially altering their effects.
This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.
📋Before taking it▾
- Do not take sertraline if you have taken an MAOI in the past 14 days — or plan to start one within 14 days of stopping sertraline
- Do not take sertraline if you are allergic to it (anaphylaxis or angioedema have been reported)
- Do not take pimozide at the same time as sertraline
- Do not take the oral solution if you are on disulfiram
- Tell your doctor if you have bipolar disorder or a family history of it — sertraline can trigger mania
- Tell your doctor if you have ever had seizures
- Tell your doctor if you have liver disease — sertraline exposure is significantly higher with liver impairment; moderate to severe liver impairment is not recommended
- Tell your doctor if you are pregnant: third-trimester use is linked to neonatal complications including persistent pulmonary hypertension of the newborn (PPHN) and withdrawal symptoms in the baby
- Breastfeeding: sertraline passes into breast milk at low levels; discuss risks and benefits with your doctor
- Children: sertraline is only established as safe and effective for OCD in patients ages 6 and older — not for depression in children
- Older adults: the body clears sertraline more slowly with age; closer monitoring is appropriate
- Tell your doctor about all other medications, supplements, and herbal products you take
🚑If you take too much▾
Taking too much sertraline can cause serious symptoms including extreme drowsiness, vomiting, rapid heart rate, nausea, dizziness, agitation, tremor, and — in severe cases — seizures, heart rhythm abnormalities, serotonin syndrome, and loss of consciousness. If you or someone else may have taken too much, call 911 or your local poison control center immediately.
There is no specific antidote for sertraline overdose. Treatment focuses on supportive care — maintaining breathing, monitoring the heart, and managing symptoms. Activated charcoal may be used if administered soon after ingestion. Dialysis is unlikely to help due to how extensively sertraline binds to proteins in the body.
📡Pharmacodynamics — effects in the body▾
At typical therapeutic doses, sertraline measurably blocks serotonin uptake into human platelets — one way researchers confirm it is working in the body. It has very weak effects on norepinephrine and dopamine reuptake, and does not significantly bind to receptors associated with sedation, anticholinergic effects, or cardiovascular changes seen with older antidepressants. Sertraline also does not inhibit monoamine oxidase.
Sertraline has a small but measurable effect on heart electrical activity: at approximately double the maximum recommended daily dose, it prolonged the QTc interval (a measure of the heart's electrical recovery time) by about 10 milliseconds. The effect is dose- and concentration-related, so keeping within recommended doses is important.
🔬Pharmacokinetics — how your body processes it▾
After a once-daily oral dose, sertraline reaches peak blood levels within roughly 4.5 to 8.4 hours. Its half-life — the time it takes for half the drug to leave the body — is about 26 hours, which is why it is dosed once daily and why steady, stable blood levels are reached after about one week of regular dosing. Taking it with food slightly increases peak concentration and speeds absorption for tablets, but the overall amount absorbed is similar.
Sertraline is extensively broken down by the liver before it reaches the bloodstream (a process called first-pass metabolism), and it is 98% bound to proteins in the blood. The main breakdown product, N-desmethylsertraline, is much less active and has a much longer half-life (62 to 104 hours). Older adults clear sertraline about 40% more slowly than younger adults, and people with even mild liver disease have roughly 3 times greater exposure — both groups need careful monitoring. Kidney disease does not significantly affect sertraline blood levels.
📦How to store it▾
Store at 20° to 25°C (68° to 77°F) .
📄 Written from Sertraline’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →
Supplements & herbs that interact with Sertraline
188 supplements and herbal products have documented interactions with Sertraline in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.
- Major · 9
- Moderate · 139
- Minor · 40
Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.
Nutrient depletion considerations
Sertraline has been associated with lower levels of 1 nutrient in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.
Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.
🩺 Pharmacist Counseling Corner
Quick, plain-English answers to the questions patients ask most about Sertraline — the kind of thing our pharmacy team would talk through with you at the counter.
How long does it take for sertraline to start working? ▾
Is it okay to take sertraline with ibuprofen or aspirin? ▾
What should I do if I want to stop taking sertraline? ▾
Are there any medicines I absolutely cannot take with sertraline? ▾
I'm pregnant — is sertraline safe to take? ▾
My child has OCD — can they take sertraline? ▾
Is Sertraline available over the counter? ▾
When was Sertraline first available? ▾
Who makes Sertraline? ▾
💬 Answers drafted from Sertraline’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →
🧰 Keep exploring
💊 How Sertraline comes
Sertraline is available in 3 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
📊 Sertraline across the U.S. market
How Sertraline appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
Also listed with the FDA, not a patient dose form: Powder (23) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
📈 How widely Sertraline is used
A general measure of how commonly Sertraline is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Sertraline is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Sertraline prescribed? Of the 1,597 medications we measure, Sertraline ranks #13 by Medicaid prescriptions — more than 99% of them.
Utilization by Sertraline product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
sertraline 100 MG Oral Tablet Most dispensed
Summed across the 37 of 398 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 312938
sertraline 50 MG Oral Tablet
Summed across the 36 of 382 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 312941
sertraline 25 MG Oral Tablet
Summed across the 29 of 253 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 312940
sertraline 20 MG/ML Oral Solution
Summed across the 3 of 12 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 861064
sertraline 150 MG Oral Capsule
Summed across the 3 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 410584
sertraline 200 MG Oral Capsule
Summed across the 3 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 251201
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Sertraline, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 111 of 1,063 listed Sertraline NDCs with Medicaid activity.
🔍 Compare Sertraline products
A representative set of FDA-listed product records for Sertraline — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Capsule | ||||
| 150 mg | Oral | Almatica Pharma LLC × 3 listings | NDA | View NDC → |
| 200 mg | Oral | Almatica Pharma LLC × 3 listings | NDA | View NDC → |
| 150 mg | Oral | Alvogen, Inc. | NDA AUTHORIZED GENERIC | View NDC → |
| 200 mg | Oral | Alvogen, Inc. | NDA AUTHORIZED GENERIC | View NDC → |
| 150 mg | Oral | Amneal Pharmaceuticals NY LLC | ANDA | View NDC → |
| 200 mg | Oral | Amneal Pharmaceuticals NY LLC | ANDA | View NDC → |
| 150 mg | Oral | ANI Pharmaceuticals, Inc. | ANDA | View NDC → |
| 200 mg | Oral | ANI Pharmaceuticals, Inc. | ANDA | View NDC → |
| 150 mg | Oral | Biocon Pharma Inc. | ANDA | View NDC → |
| 200 mg | Oral | Biocon Pharma Inc. | ANDA | View NDC → |
| 150 mg | Oral | Cipla USA Inc. | ANDA | View NDC → |
| 200 mg | Oral | Cipla USA Inc. | ANDA | View NDC → |
| 150 mg | Oral | Dr. Reddy's Laboratories Inc. | ANDA | View NDC → |
| 200 mg | Oral | Dr. Reddy's Laboratories Inc. | ANDA | View NDC → |
| 150 mg | Oral | Umedica Laboratories USA Inc. | ANDA | View NDC → |
| 200 mg | Oral | Umedica Laboratories USA Inc. | ANDA | View NDC → |
| 150 mg | Oral | Zydus Lifesciences Limited | ANDA | View NDC → |
| 200 mg | Oral | Zydus Lifesciences Limited | ANDA | View NDC → |
| 150 mg | Oral | Zydus Pharmaceuticals (USA) Inc. | ANDA | View NDC → |
| 200 mg | Oral | Zydus Pharmaceuticals (USA) Inc. | ANDA | View NDC → |
| 💊Oral solution | ||||
| 20 mg/mL | Oral | ACI Healthcare USA, Inc. × 2 listings | ANDA | View NDC → |
| 20 mg/mL | Oral | Aurobindo Pharma Limited × 3 listings | ANDA | View NDC → |
| 20 mg/mL | Oral | Bryant Ranch Prepack × 3 listings | ANDA | View NDC → |
| 20 mg/mL | Oral | Greenstone LLC × 2 listings | NDA AUTHORIZED GENERIC | View NDC → |
| 20 mg/mL | Oral | Mylan Pharmaceuticals Inc. | NDA AUTHORIZED GENERIC | View NDC → |
| 20 mg/mL | Oral | NorthStar Rx LLC × 3 listings | ANDA | View NDC → |
| 20 mg/mL | Oral | Rising Pharmaceuticals, Inc. | ANDA | View NDC → |
| 20 mg/mL | Oral | Rising Pharma Holdings, Inc. × 2 listings | ANDA | View NDC → |
| 20 mg/mL | Oral | Roerig × 3 listings | NDA | View NDC → |
| 20 mg/mL | Oral | Viatris Specialty LLC × 2 listings | NDA | View NDC → |
| 💊Tablet | ||||
| 25 mg | Oral | A-S Medication Solutions × 9 listings | ANDA | View NDC → |
| 50 mg | Oral | A-S Medication Solutions × 10 listings | ANDA | View NDC → |
| 100 mg | Oral | A-S Medication Solutions × 8 listings | ANDA | View NDC → |
| 25 mg | Oral | ACI Healthcare USA, Inc. × 2 listings | ANDA | View NDC → |
| 50 mg | Oral | ACI Healthcare USA, Inc. × 2 listings | ANDA | View NDC → |
| 100 mg | Oral | ACI Healthcare USA, Inc. × 2 listings | ANDA | View NDC → |
| 25 mg | Oral | American Health Packaging × 3 listings | ANDA | View NDC → |
| 50 mg | Oral | American Health Packaging × 3 listings | ANDA | View NDC → |
| 100 mg | Oral | American Health Packaging × 3 listings | ANDA | View NDC → |
| 25 mg | Oral | Aphena Pharma Solutions - Tennessee, LLC | ANDA | View NDC → |
| 100 mg | Oral | Aphena Pharma Solutions - Tennessee, LLC | ANDA | View NDC → |
| 25 mg | Oral | Ascent Pharmaceuticals, Inc. | ANDA | View NDC → |
| 50 mg | Oral | Ascent Pharmaceuticals, Inc. | ANDA | View NDC → |
| 100 mg | Oral | Ascent Pharmaceuticals, Inc. | ANDA | View NDC → |
| 25 mg | Oral | Bryant Ranch Prepack × 2 listings | ANDA | View NDC → |
| 50 mg | Oral | Bryant Ranch Prepack | ANDA | View NDC → |
| 100 mg | Oral | Bryant Ranch Prepack × 2 listings | ANDA | View NDC → |
| 25 mg | Oral | Camber Pharmaceuticals, Inc. × 3 listings | ANDA | View NDC → |
| 50 mg | Oral | Camber Pharmaceuticals, Inc. × 3 listings | ANDA | View NDC → |
| 100 mg | Oral | Camber Pharmaceuticals, Inc. × 3 listings | ANDA | View NDC → |
| 50 mg | Oral | Cardinal Health | ANDA | View NDC → |
| 100 mg | Oral | Cardinal Health | ANDA | View NDC → |
| 50 mg | Oral | Cardinal Health 107, LLC × 3 listings | ANDA | View NDC → |
| 100 mg | Oral | Cardinal Health 107, LLC × 3 listings | ANDA | View NDC → |
| 25 mg | Oral | Cipla USA Inc. × 4 listings | ANDA | View NDC → |
| 50 mg | Oral | Cipla USA Inc. × 4 listings | ANDA | View NDC → |
| 100 mg | Oral | Cipla USA Inc. × 4 listings | ANDA | View NDC → |
| 50 mg | Oral | Clinical Solutions Wholesale, LLC | ANDA | View NDC → |
| 25 mg | Oral | Coupler LLC | ANDA | View NDC → |
| 100 mg | Oral | Direct Rx × 2 listings | ANDA | View NDC → |
| 25 mg | Oral | Legacy Pharmaceutical Packaging, LLC × 3 listings | ANDA | View NDC → |
| 50 mg | Oral | Legacy Pharmaceutical Packaging, LLC × 3 listings | ANDA | View NDC → |
| 100 mg | Oral | Legacy Pharmaceutical Packaging, LLC × 3 listings | ANDA | View NDC → |
| 50 mg | Oral | Medsource Pharmaceuticals | ANDA | View NDC → |
| 25 mg | Oral | Northwind Health Company, LLC | ANDA | View NDC → |
| 25 mg | Oral | Northwind Pharmaceuticals | ANDA | View NDC → |
| 25 mg | Oral | Northwind Pharmaceuticals, LLC | ANDA | View NDC → |
| 25 mg | Oral | NuCare Pharmaceuticals, Inc. × 2 listings | ANDA | View NDC → |
| 50 mg | Oral | NuCare Pharmaceuticals, Inc. | ANDA | Find on DailyMed ↗ |
| 50 mg | Oral | NuCare Pharmaceuticals,Inc. | ANDA | View NDC → |
| 100 mg | Oral | NuCare Pharmaceuticals,Inc. × 3 listings | ANDA | View NDC → |
| 50 mg | Oral | PD-Rx Pharmaceuticals, Inc. × 4 listings | ANDA | View NDC → |
| 100 mg | Oral | PD-Rx Pharmaceuticals, Inc. × 4 listings | ANDA | View NDC → |
| 25 mg | Oral | Proficient Rx LP | ANDA | View NDC → |
| 50 mg | Oral | Proficient Rx LP | ANDA | View NDC → |
| 100 mg | Oral | Proficient Rx LP | ANDA | View NDC → |
| 25 mg | Oral | Remedyrepack Inc. | ANDA | View NDC → |
| 100 mg | Oral | Remedyrepack Inc. × 2 listings | ANDA | View NDC → |
| 25 mg | Oral | RPK Pharmaceuticals, Inc. × 2 listings | ANDA | View NDC → |
| 50 mg | Oral | RPK Pharmaceuticals, Inc. × 2 listings | ANDA | View NDC → |
| 100 mg | Oral | RPK Pharmaceuticals, Inc. × 2 listings | ANDA | View NDC → |
| 25 mg | Oral | XLCare Pharmaceuticals, Inc. × 2 listings | ANDA | View NDC → |
| 50 mg | Oral | XLCare Pharmaceuticals, Inc. × 2 listings | ANDA | View NDC → |
| 100 mg | Oral | XLCare Pharmaceuticals, Inc. × 2 listings | ANDA | View NDC → |
| 💊Bulk drug substance | ||||
| 1 kg/kg | — | Amoli Organics (A Division of Umedica Laboratories Pvt.Ltd.) | BULK INGREDIENT | View NDC → |
| 50 kg/50 kg | — | Aurobindo Pharma Limited × 2 listings | BULK INGREDIENT | View NDC → |
| 25 kg/25 kg | — | Chemeca Drugs Private Limited | BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING | View NDC → |
| 50 kg/50 kg | — | Chemeca Drugs Private Limited | BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING | View NDC → |
| 1 kg/kg | — | Exemed Pharmaceuticals × 2 listings | BULK INGREDIENT | View NDC → |
| 1 kg/kg | — | Hetero Drugs Limited × 4 listings | BULK INGREDIENT | View NDC → |
| 1 kg/kg | — | Matrix Pharmacorp Private Limited × 2 listings | BULK INGREDIENT | View NDC → |
| 10 kg/10 kg | — | Matrix Pharmacorp Private Limited | BULK INGREDIENT | View NDC → |
| 1 g/g | — | Medisca | BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING | View NDC → |
| 1 kg/kg | — | Professional Compounding Centers of America dba PCCA | BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING | View NDC → |
| 1 kg/kg | — | Symed Labs Limited | BULK INGREDIENT | View NDC → |
| 1 kg/kg | — | Viatris Pharmaceuticals LLC | BULK INGREDIENT | View NDC → |
| 1 kg/kg | — | Viyash Life Sciences Private Limited | BULK INGREDIENT | View NDC → |
| 1 kg/kg | — | Viyash Scientific Limited × 2 listings | BULK INGREDIENT | View NDC → |
| 1 kg/kg | — | Wanbury Limited | BULK INGREDIENT | View NDC → |
| 1 kg/kg | — | Zhejiang Huahai Pharmaceutical Co., Ltd. | BULK INGREDIENT | View NDC → |
Showing 200 of 588 products — FDA National Drug Code Directory. See every product, package size and price: browse all 588 Sertraline NDCs →
📈 What people report — real-world data (FDA FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Sertraline — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Sertraline in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
🏛️ The road to your pharmacy
How Sertraline went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
🚨 Recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
Source: openFDA drug enforcement (recall) reports.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 36437 3 dose forms · 6 strengths
-
Dose form (SCDF) Oral Capsule RxCUI 373867In current FDA listings -
Dose form (SCDF) Oral Solution RxCUI 374622In current FDA listingsClinical drug / strength (SCD) 20 MG/MLRxCUI 861064 -
Dose form (SCDF) Oral Tablet RxCUI 373868In current FDA listings
Look up RxCUI 36437 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
📦 Supply & shortage status
Whether Sertraline is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
🏷️ Sold under these brand names
🏭 Manufacturers & labelers
…and 16 more on the FDA NDC directory.
RxNorm drug class
Sertraline belongs to the Serotonin Reuptake Inhibitor class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
🔬 Where this comes from
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How we combine label and product data
HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 184 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.
For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Proficient Rx LP is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.
This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.