Sertraline

Generic name: Pronounced as (ser' tra leen)
Brand names
  • Zoloft®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 01/15/2022

A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as sertraline during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant.

You should know that your mental health may change in unexpected ways when you take sertraline or other antidepressants even if you are an adult over 24 years of age. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; new or worsening anxiety; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.

Your healthcare provider will want to see you often while you are taking sertraline, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor.

The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with sertraline. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm.

No matter what your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you.

Sertraline is used to treat depression, obsessive-compulsive disorder (bothersome thoughts that won't go away and the need to perform certain actions over and over), panic attacks (sudden, unexpected attacks of extreme fear and worry about these attacks), posttraumatic stress disorder (disturbing psychological symptoms that develop after a frightening experience), and social anxiety disorder (extreme fear of interacting with others or performing in front of others that interferes with normal life). It is also used to relieve the symptoms of premenstrual dysphoric disorder, including mood swings, irritability, bloating, and breast tenderness. Sertraline is in a class of antidepressants called selective serotonin reuptake inhibitors (SSRIs). It works by increasing the amounts of serotonin, a natural substance in the brain that helps maintain mental balance.

Sertraline comes as a tablet and a concentrate (liquid) to take by mouth. It is usually taken once daily in the morning or evening. To treat premenstrual dysphoric disorder, sertraline is taken once a day, either every day of the month or on certain days of the month. Take sertraline at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sertraline exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Sertraline concentrate must be diluted before use. Immediately before taking it, use the provided dropper to remove the amount of concentrate your doctor has told you to take. Mix the concentrate with 4 ounces (1/2 cup [120 milliliters]) of water, ginger ale, lemon or lime soda, lemonade, or orange juice. After mixing, the diluted solution may be hazy; this is normal. Do not mix the concentrate with any liquids other than the ones listed. Drink the diluted solution immediately.

Your doctor may start you on a low dose of sertraline and gradually increase your dose, not more than once a week.

It may take a few weeks or longer before you feel the full benefit of sertraline. Continue to take sertraline even if you feel well. Do not stop taking sertraline without talking to your doctor. If you suddenly stop taking sertraline, you may experience withdrawal symptoms such as nausea, sweating, depression, mood changes, frenzied or abnormally excited mood, irritability, anxiety, confusion, dizziness, headache, tiredness, seizures, ringing in the ears, numbness or tingling in the arms, legs, hands, or feet, difficulty falling asleep or staying asleep.

Sertraline is also used sometimes to treat headaches and sexual problems. Talk to your doctor about the possible risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking sertraline,

  • tell your doctor and pharmacist if you are allergic to sertraline, any other medications, any of the ingredients in sertraline preparations, or latex (found in the dropper for the concentrate). Before taking sertraline liquid concentrate, tell your doctor if you are allergic to latex. Ask your pharmacist for a list of the ingredients.

  • tell your doctor if you are taking monoamine oxidase (MAO) inhibitors including isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Emsam, Zelapar), and tranylcypromine (Parnate), or have stopped taking them within the past 2 weeks, or if you are taking pimozide (Orap). Your doctor will probably tell you not to take sertraline. If you stop taking sertraline, you should wait at least 2 weeks before you start to take an MAO inhibitor.

  • do not take disulfiram (Antabuse) while taking sertraline oral concentrate.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Nexterone, Pacerone); amphetamines; anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven) and heparin; aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); atomoxetine (Straterra); buspirone, chlorpromazine; clopidogrel (Plavix), dextromethorphan (found in many cough medications; in Nuedexta); fentanyl (Actiq, Fentora, Lazanda, others), droperidol (Inapsine); erythromycin (E.E.S, Eryc, Ery-tab, others); fosphenytoin (Cerebyx); iloperidone (Fanapt); lithium (Lithobid); medications for anxiety, mental illness, Parkinson's disease, and seizures; medications for irregular heartbeat such as flecainide and propafenone (Rythmol); metoprolol (Lopressor, Toprol XL); medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); mefloquine; methadone (Dolophine, Methadose); moxifloxacin (Avelox); nebivolol (Bystolic, in Byvalson); pentamidine (Nebupent, Pentam); perphenazine; phenytoin (Dilantin, Phenytek); procainamide; quinidine (in Nuedexta); sedatives; sleeping pills; other selective serotonin-reuptake inhibitors such as citalopram (Celexa), fluoxetine (Prozac), or fluvoxamine (Luvox); serotonin–norepinephrine reuptake inhibitors (SNRI) medications such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), levomilnacipran (Fetzima), and venlafaxine; sotalol (Betapace, Sotylize); tacrolimus (Astagraf, Envarsus XR, Prograf); thioridazine; tolterodine (Detrol); tramadol (Conzip, Qdolo, Ultram); tranquilizers; tricyclic antidepressants ('mood elevators') such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin, imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine; or ziprasidone (Geodon). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with sertraline, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor what herbal products and nutritional supplements you are taking, especially St. John's wort and tryptophan.

  • tell your doctor if you have recently had a heart attack or stroke or if you have high blood pressure, bleeding problems, a low level of sodium in your blood and if you have or have ever had seizures or liver, kidney, or heart disease.

  • tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, or if you plan to become pregnant or are breastfeeding. If you become pregnant while taking sertraline, call your doctor. Sertraline may cause problems in newborns following delivery if it is taken during the last months of pregnancy.

  • you should know that sertraline may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.

  • ask your doctor about the safe use of alcoholic beverages while you are taking sertraline.

  • you should know that sertraline may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Sertraline may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • diarrhea

    • constipation

    • vomiting

    • difficulty falling asleep or staying asleep

    • dry mouth

    • heartburn

    • loss of appetite

    • weight changes

    • dizziness

    • excessive tiredness

    • headache

    • nervousness

    • uncontrollable shaking of a part of the body

    • sexual problems in males; decreased sex drive, inability to get or keep an erection, or delayed or absent ejaculation

    • sexual problems in females; decreased sex drive, or delayed orgasm or unable to have an orgasm

    • excessive sweating

  • Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS section, call your doctor immediately:

    • seizures

    • abnormal bleeding or bruising

    • agitation, hallucinations, fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea

    • headache, weakness, unsteadiness, confusion, or memory problems

    • rash

    • hives

    • swelling

    • difficulty breathing

  • Sertraline may decrease appetite and cause weight loss in children. Your child's doctor will watch his or her growth carefully. Talk to your child's doctor if you have concerns about your child's growth or weight while he or she is taking this medication. Talk to your child's doctor about the risks of giving sertraline to your child.

  • Sertraline may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • drowsiness

  • agitation, hallucinations, fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea

  • excessive tiredness

  • dizziness

  • agitation

  • mania

  • seizures

  • loss of consciousness

  • dizziness

  • rapid, irregular, or pounding heartbeat

Keep all appointments with your doctor.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking sertraline.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The risk or severity of hypoglycemia can be increased when Repaglinide is combined with Sertraline.
Montelukast Montelukast The metabolism of Montelukast can be decreased when combined with Sertraline.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The risk or severity of hypoglycemia can be increased when Insulin glargine is combined with Sertraline.
Leflunomide Leflunomide The metabolism of Sertraline can be decreased when combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Sertraline can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Nevirapine can be decreased when combined with Sertraline.
Dolasetron Dolasetron The risk or severity of adverse effects can be increased when Dolasetron is combined with Sertraline.
Anagrelide Anagrelide The risk or severity of bleeding can be increased when Sertraline is combined with Anagrelide.
Candesartan Candesartan The metabolism of Candesartan can be decreased when combined with Sertraline.
Cilostazol Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Sertraline.
Clopidogrel Clopidogrel The serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Sertraline resulting in a loss in efficacy.
Diphenoxylate Diphenoxylate The risk or severity of serotonin syndrome can be increased when Diphenoxylate is combined with Sertraline.
Fenofibrate Fenofibrate The metabolism of Sertraline can be decreased when combined with Fenofibrate.
Guanfacine Guanfacine The risk or severity of adverse effects can be increased when Guanfacine is combined with Sertraline.
Miglitol Miglitol The risk or severity of hypoglycemia can be increased when Miglitol is combined with Sertraline.
Naratriptan Naratriptan The risk or severity of adverse effects can be increased when Naratriptan is combined with Sertraline.
Olsalazine Olsalazine The risk or severity of bleeding can be increased when Sertraline is combined with Olsalazine.
Paregoric Paregoric The risk or severity of serotonin syndrome can be increased when Morphine is combined with Sertraline.
Penbutolol Penbutolol The metabolism of Sertraline can be decreased when combined with Acebutolol.
Pentazocine Pentazocine The risk or severity of serotonin syndrome can be increased when Pentazocine is combined with Sertraline.
Ranitidine Ranitidine The metabolism of Sertraline can be decreased when combined with Ranitidine.
Reserpine Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Sertraline.
Rizatriptan Rizatriptan The risk or severity of adverse effects can be increased when Rizatriptan is combined with Sertraline.
Sumatriptan Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Sertraline.
Tizanidine Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Sertraline.
Zolmitriptan Zolmitriptan The risk or severity of serotonin syndrome can be increased when Zolmitriptan is combined with Sertraline.
Fluconazole Injection Fluconazole Injection The metabolism of Sertraline can be decreased when combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The risk or severity of serotonin syndrome can be increased when Hydromorphone is combined with Sertraline.
Meperidine Injection Meperidine Injection The risk or severity of serotonin syndrome can be increased when Sertraline is combined with Meperidine.
Metoclopramide Injection Metoclopramide Injection The risk or severity of sedation can be increased when Metoclopramide is combined with Sertraline.
Metronidazole Injection Metronidazole Injection The metabolism of Sertraline can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The risk or severity of serotonin syndrome can be increased when Morphine is combined with Sertraline.
Zidovudine Injection Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Sertraline.
Altretamine Altretamine The risk or severity of serotonin syndrome can be increased when Amphetamine is combined with Sertraline.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Sertraline.
Ondansetron Ondansetron The risk or severity of adverse effects can be increased when Ondansetron is combined with Sertraline.
Enoxaparin Injection Enoxaparin Injection The risk or severity of bleeding can be increased when Sertraline is combined with Enoxaparin.
Granisetron Granisetron The risk or severity of adverse effects can be increased when Granisetron is combined with Sertraline.
Torsemide Torsemide The metabolism of Sertraline can be decreased when combined with Torasemide.
Olanzapine Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Sertraline.
Alosetron Alosetron The risk or severity of adverse effects can be increased when Alosetron is combined with Sertraline.
Entacapone Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Sertraline.
Hydroxychloroquine Hydroxychloroquine The metabolism of Sertraline can be decreased when combined with Hydroxychloroquine.
Meloxicam Meloxicam The risk or severity of bleeding can be increased when Sertraline is combined with Meloxicam.
Oxcarbazepine Oxcarbazepine The risk or severity of adverse effects can be increased when Oxcarbazepine is combined with Sertraline.
Pantoprazole Pantoprazole The metabolism of Sertraline can be decreased when combined with Pantoprazole.
Telmisartan Telmisartan The metabolism of Sertraline can be decreased when combined with Telmisartan.
Zaleplon Zaleplon The risk or severity of adverse effects can be increased when Zaleplon is combined with Sertraline.
Anakinra Anakinra The metabolism of Sertraline can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of adverse effects can be increased when Desloratadine is combined with Sertraline.
Linezolid Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Sertraline.
Pentosan Polysulfate Pentosan Polysulfate The risk or severity of bleeding can be increased when Sertraline is combined with Pentosan polysulfate.
Trimipramine Trimipramine The metabolism of Sertraline can be decreased when combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Sertraline can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate Sertraline may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Modafinil Modafinil The metabolism of Sertraline can be decreased when combined with Modafinil.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of bleeding can be increased when Sertraline is combined with Choline magnesium trisalicylate.
Epinephrine Injection Epinephrine Injection The metabolism of Sertraline can be decreased when combined with Epinephrine.
Escitalopram Escitalopram The risk or severity of serotonin syndrome can be increased when Sertraline is combined with Escitalopram.
Zonisamide Zonisamide The risk or severity of adverse effects can be increased when Zonisamide is combined with Sertraline.
Adalimumab Injection Adalimumab Injection The metabolism of Sertraline can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The serum concentration of Aripiprazole can be increased when it is combined with Sertraline.
Atomoxetine Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Sertraline.
Dexmethylphenidate Dexmethylphenidate The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with Sertraline.
Teriparatide Injection Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Sertraline.
Atazanavir Atazanavir The metabolism of Sertraline can be decreased when combined with Atazanavir.
Almotriptan Almotriptan The risk or severity of adverse effects can be increased when Almotriptan is combined with Sertraline.
Eletriptan Eletriptan The metabolism of Eletriptan can be decreased when combined with Sertraline.
Mefloquine Mefloquine The metabolism of Sertraline can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Sertraline.
Aprepitant Aprepitant The metabolism of Sertraline can be decreased when combined with Aprepitant.
Memantine Memantine The metabolism of Sertraline can be decreased when combined with Memantine.
Tegaserod Tegaserod The metabolism of Tegaserod can be decreased when combined with Sertraline.
Frovatriptan Frovatriptan The risk or severity of adverse effects can be increased when Frovatriptan is combined with Sertraline.
Progesterone Progesterone The metabolism of Progesterone can be decreased when combined with Sertraline.
Apomorphine Injection Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Sertraline.
Infliximab Injection Infliximab Injection The metabolism of Sertraline can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Sertraline can be decreased when combined with Oxandrolone.
Protriptyline Protriptyline The risk or severity of adverse effects can be increased when Protriptyline is combined with Sertraline.
Rifaximin Rifaximin The metabolism of Sertraline can be increased when combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Sertraline can be decreased when combined with Duloxetine.
Trospium Trospium Sertraline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan Bosentan The metabolism of Sertraline can be increased when combined with Bosentan.
Cinacalcet Cinacalcet The metabolism of Sertraline can be decreased when combined with Cinacalcet.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Sertraline.
Eszopiclone Eszopiclone The risk or severity of CNS depression can be increased when Sertraline is combined with Eszopiclone.
Insulin Aspart (rDNA Origin) Injection Insulin Aspart (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Insulin aspart.
Solifenacin Solifenacin Sertraline may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Voriconazole Voriconazole The metabolism of Voriconazole can be decreased when combined with Sertraline.
Dextroamphetamine Dextroamphetamine The risk or severity of serotonin syndrome can be increased when Amphetamine is combined with Sertraline.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Sertraline can be increased when combined with Peginterferon alfa-2b.
Pramlintide Injection Pramlintide Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Pramlintide.
Sodium Oxybate Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Sertraline.
Exenatide Injection Exenatide Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Exenatide.
Isocarboxazid Isocarboxazid The risk or severity of serotonin syndrome can be increased when Sertraline is combined with Isocarboxazid.
Ramelteon Ramelteon The risk or severity of adverse effects can be increased when Ramelteon is combined with Sertraline.
Darifenacin Darifenacin The metabolism of Darifenacin can be decreased when combined with Sertraline.
Fentanyl Fentanyl The risk or severity of serotonin syndrome can be increased when Fentanyl is combined with Sertraline.
Pregabalin Pregabalin The therapeutic efficacy of Sertraline can be increased when used in combination with Pregabalin.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Sertraline.
Felbamate Felbamate The risk or severity of adverse effects can be increased when Felbamate is combined with Sertraline.
Insulin Detemir (rDNA Origin) Injection Insulin Detemir (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Insulin detemir.
Ranolazine Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Sertraline.
Abatacept Injection Abatacept Injection The metabolism of Sertraline can be increased when combined with Abatacept.
Rasagiline Rasagiline The risk or severity of serotonin syndrome can be increased when Rasagiline is combined with Sertraline.
Imatinib Imatinib The metabolism of Sertraline can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The risk or severity of hypoglycemia can be increased when Sertraline is combined with Sitagliptin.
Gefitinib Gefitinib The metabolism of Sertraline can be decreased when combined with Gefitinib.
Paliperidone Paliperidone The risk or severity of adverse effects can be increased when Sertraline is combined with Paliperidone.
Bortezomib Bortezomib The metabolism of Sertraline can be decreased when combined with Bortezomib.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Insulin glulisine.
Primaquine Primaquine The metabolism of Primaquine can be decreased when combined with Sertraline.
Darunavir Darunavir The serum concentration of Sertraline can be decreased when it is combined with Darunavir.
Dimenhydrinate Dimenhydrinate The risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Sertraline.
Lisdexamfetamine Lisdexamfetamine The risk or severity of serotonin syndrome can be increased when Sertraline is combined with Lisdexamfetamine.
Nabilone Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Sertraline.
Sorafenib Sorafenib The metabolism of Sertraline can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The risk or severity of hypoglycemia can be increased when Sertraline is combined with Sunitinib.
Dronabinol Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Sertraline.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Sertraline.
Levocetirizine Levocetirizine The risk or severity of adverse effects can be increased when Levocetirizine is combined with Sertraline.
Mexiletine Mexiletine The metabolism of Mexiletine can be decreased when combined with Sertraline.
Armodafinil Armodafinil The metabolism of Sertraline can be decreased when combined with Armodafinil.
Temsirolimus Temsirolimus The metabolism of Sertraline can be decreased when combined with Temsirolimus.
Nilotinib Nilotinib The metabolism of Nilotinib can be decreased when combined with Sertraline.
Bexarotene Bexarotene The metabolism of Bexarotene can be decreased when combined with Sertraline.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Sertraline can be decreased when combined with Chloramphenicol.
Desmopressin Desmopressin The risk or severity of hyponatremia can be increased when Sertraline is combined with Desmopressin.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Sertraline.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Sertraline.
Etravirine Etravirine The metabolism of Etravirine can be decreased when combined with Sertraline.
Desvenlafaxine Desvenlafaxine The risk or severity of adverse effects can be increased when Sertraline is combined with Desvenlafaxine.
Cevimeline Cevimeline The metabolism of Cevimeline can be decreased when combined with Sertraline.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Sertraline.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Sertraline.
Flecainide Flecainide The metabolism of Sertraline can be decreased when combined with Flecainide.
Certolizumab Injection Certolizumab Injection The metabolism of Sertraline can be increased when combined with Certolizumab pegol.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Sertraline.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Sertraline.
Rufinamide Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Sertraline.
Midazolam Midazolam The risk or severity of adverse effects can be increased when Midazolam is combined with Sertraline.
Naltrexone Injection Naltrexone Injection The risk or severity of serotonin syndrome can be increased when Naltrexone is combined with Sertraline.
Milnacipran Milnacipran The risk or severity of adverse effects can be increased when Sertraline is combined with Milnacipran.
Dexlansoprazole Dexlansoprazole The metabolism of Dexlansoprazole can be decreased when combined with Sertraline.
Fesoterodine Fesoterodine Sertraline may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Betaxolol Betaxolol The serum concentration of Betaxolol can be increased when it is combined with Sertraline.
Iloperidone Iloperidone The risk or severity of adverse effects can be increased when Sertraline is combined with Iloperidone.
Prasugrel Prasugrel The risk or severity of bleeding can be increased when Sertraline is combined with Prasugrel.
Lacosamide Lacosamide The risk or severity of adverse effects can be increased when Lacosamide is combined with Sertraline.
Everolimus Everolimus The metabolism of Sertraline can be decreased when combined with Everolimus.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Sertraline.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Sertraline.
Palonosetron Injection Palonosetron Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Sertraline.
Saxagliptin Saxagliptin The risk or severity of hypoglycemia can be increased when Sertraline is combined with Saxagliptin.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Sertraline.
Tapentadol Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Sertraline.
Golimumab Injection Golimumab Injection The metabolism of Sertraline can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Sertraline.
Asenapine Asenapine The risk or severity of adverse effects can be increased when Sertraline is combined with Asenapine.
Vigabatrin Vigabatrin The risk or severity of adverse effects can be increased when Vigabatrin is combined with Sertraline.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Sertraline.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Sertraline.
Oxymorphone Oxymorphone The risk or severity of serotonin syndrome can be increased when Oxymorphone is combined with Sertraline.
Dabigatran Dabigatran The risk or severity of bleeding can be increased when Sertraline is combined with Dabigatran.
Liraglutide Injection Liraglutide Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Liraglutide.
Tocilizumab Injection Tocilizumab Injection The metabolism of Sertraline can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine The risk or severity of seizure can be increased when Sertraline is combined with Dalfampridine.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Sertraline.
Lurasidone Lurasidone The risk or severity of adverse effects can be increased when Lurasidone is combined with Sertraline.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Sertraline.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Sertraline.
Linagliptin Linagliptin The risk or severity of hypoglycemia can be increased when Sertraline is combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Sertraline can be decreased when combined with Rilpivirine.
Potassium Iodide Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Sertraline.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Sertraline.
Abiraterone Abiraterone The metabolism of Sertraline can be decreased when combined with Abiraterone.
Rivaroxaban Rivaroxaban The risk or severity of bleeding can be increased when Sertraline is combined with Rivaroxaban.
Ticagrelor Ticagrelor The risk or severity of bleeding can be increased when Sertraline is combined with Ticagrelor.
Clobazam Clobazam The metabolism of Sertraline can be decreased when combined with Clobazam.
Vemurafenib Vemurafenib The metabolism of Sertraline can be decreased when combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Vismodegib can be decreased when combined with Sertraline.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Sertraline.
Cabergoline Cabergoline The risk or severity of adverse effects can be increased when Cabergoline is combined with Sertraline.
Fondaparinux Injection Fondaparinux Injection The risk or severity of bleeding can be increased when Sertraline is combined with Fondaparinux.
Ezogabine Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Sertraline.
Iloprost Iloprost The risk or severity of bleeding can be increased when Sertraline is combined with Iloprost.
Enzalutamide Enzalutamide The metabolism of Sertraline can be increased when combined with Enzalutamide.
Mirabegron Mirabegron The metabolism of Mirabegron can be decreased when combined with Sertraline.
Regorafenib Regorafenib The metabolism of Sertraline can be decreased when combined with Regorafenib.
Lorcaserin Lorcaserin The risk or severity of hypoglycemia can be increased when Sertraline is combined with Mecasermin.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Sertraline.
Icosapent Ethyl Icosapent Ethyl The risk or severity of bleeding can be increased when Sertraline is combined with Icosapent ethyl.
Alogliptin Alogliptin The risk or severity of hypoglycemia can be increased when Sertraline is combined with Alogliptin.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Sertraline.
Pomalidomide Pomalidomide The risk or severity of adverse effects can be increased when Pomalidomide is combined with Sertraline.
Apixaban Apixaban The risk or severity of bleeding can be increased when Sertraline is combined with Apixaban.
Canagliflozin Canagliflozin The risk or severity of hypoglycemia can be increased when Sertraline is combined with Canagliflozin.
Dabrafenib Dabrafenib The serum concentration of Sertraline can be decreased when it is combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Sertraline can be decreased when combined with Ospemifene.
Levomilnacipran Levomilnacipran The risk or severity of adverse effects can be increased when Sertraline is combined with Levomilnacipran.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Sertraline.
Perampanel Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Sertraline.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Sertraline.
Ketorolac Injection Ketorolac Injection The risk or severity of bleeding can be increased when Sertraline is combined with Ketorolac.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Sertraline.
Apremilast Apremilast The metabolism of Sertraline can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Sertraline can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Sertraline can be increased when combined with Siltuximab.
Albiglutide Injection Albiglutide Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Albiglutide.
Eslicarbazepine Eslicarbazepine The risk or severity of adverse effects can be increased when Eslicarbazepine is combined with Sertraline.
Testosterone Injection Testosterone Injection The metabolism of Testosterone can be decreased when combined with Sertraline.
Oritavancin Injection Oritavancin Injection The metabolism of Sertraline can be decreased when combined with Oritavancin.
Empagliflozin Empagliflozin The risk or severity of hypoglycemia can be increased when Sertraline is combined with Empagliflozin.
Vorapaxar Vorapaxar The risk or severity of bleeding can be increased when Sertraline is combined with Vorapaxar.
Hydrocodone Hydrocodone Sertraline may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Suvorexant Suvorexant Sertraline may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Dulaglutide Injection Dulaglutide Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Dulaglutide.
Edoxaban Edoxaban The risk or severity of bleeding can be increased when Sertraline is combined with Edoxaban.
Methamphetamine Methamphetamine The risk or severity of adverse effects can be increased when Metamfetamine is combined with Sertraline.
Tasimelteon Tasimelteon The risk or severity of adverse effects can be increased when Tasimelteon is combined with Sertraline.
Lanreotide Injection Lanreotide Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Lanreotide.
Secukinumab Injection Secukinumab Injection The metabolism of Sertraline can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of adverse effects can be increased when Risperidone is combined with Sertraline.
Insulin Human Inhalation Insulin Human Inhalation The risk or severity of hypoglycemia can be increased when Insulin human is combined with Sertraline.
Lenvatinib Lenvatinib The metabolism of Sertraline can be decreased when combined with Lenvatinib.
Naloxegol Naloxegol The metabolism of Sertraline can be decreased when combined with Naloxegol.
Panobinostat Panobinostat The metabolism of Panobinostat can be decreased when combined with Sertraline.
Haloperidol Injection Haloperidol Injection The risk or severity of QTc prolongation can be increased when Haloperidol is combined with Sertraline.
Flibanserin Flibanserin The risk or severity of adverse effects can be increased when Flibanserin is combined with Sertraline.
Rolapitant Rolapitant The metabolism of Rolapitant can be decreased when combined with Sertraline.
Brexpiprazole Brexpiprazole The risk or severity of adverse effects can be increased when Sertraline is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Ziprasidone is combined with Sertraline.
Cariprazine Cariprazine The risk or severity of adverse effects can be increased when Sertraline is combined with Cariprazine.
Eluxadoline Eluxadoline The risk or severity of serotonin syndrome can be increased when Sertraline is combined with Eluxadoline.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Insulin degludec.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Sertraline.
Rifapentine Rifapentine The metabolism of Sertraline can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Sertraline.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding can be increased when Sertraline is combined with Defibrotide.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Sertraline.
Cobicistat Cobicistat The metabolism of Sertraline can be decreased when combined with Cobicistat.
Pimavanserin Pimavanserin The risk or severity of adverse effects can be increased when Sertraline is combined with Pimavanserin.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Sertraline.
Rucaparib Rucaparib The metabolism of Sertraline can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Lixisenatide.
Parathyroid Hormone Injection Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Sertraline.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Sertraline.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Sertraline.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Sertraline.
Safinamide Safinamide The risk or severity of serotonin syndrome can be increased when Safinamide is combined with Sertraline.
Midostaurin Midostaurin The metabolism of Sertraline can be decreased when combined with Midostaurin.
Abaloparatide Injection Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Sertraline.
Enasidenib Enasidenib The metabolism of Sertraline can be decreased when combined with Enasidenib.
Delafloxacin Delafloxacin The metabolism of Sertraline can be increased when combined with Delafloxacin.
Betrixaban Betrixaban The risk or severity of bleeding can be increased when Sertraline is combined with Betrixaban.
Letermovir Letermovir The metabolism of Sertraline can be increased when combined with Letermovir.
Semaglutide Injection Semaglutide Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Semaglutide.
Tetrabenazine Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Sertraline.
Ertugliflozin Ertugliflozin The risk or severity of hypoglycemia can be increased when Sertraline is combined with Ertugliflozin.
Buprenorphine Injection Buprenorphine Injection Sertraline may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide Apalutamide The serum concentration of Sertraline can be increased when it is combined with Apalutamide.
Avatrombopag Avatrombopag The metabolism of Sertraline can be increased when combined with Avatrombopag.
Lofexidine Lofexidine The therapeutic efficacy of Sertraline can be increased when used in combination with Lofexidine.
Eliglustat Eliglustat The metabolism of Sertraline can be decreased when combined with Eliglustat.
Encorafenib Encorafenib The metabolism of Encorafenib can be decreased when combined with Sertraline.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Sertraline.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Sertraline.
Cannabidiol Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Sertraline.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Sertraline.
Stiripentol Stiripentol The metabolism of Sertraline can be decreased when combined with Stiripentol.
Gilteritinib Gilteritinib The therapeutic efficacy of Sertraline can be decreased when used in combination with Gilteritinib.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Sertraline.
Rifamycin Rifamycin The metabolism of Rifamycin can be increased when combined with Sertraline.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Sertraline can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Sertraline.
Caplacizumab-yhdp Injection Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Sertraline is combined with Caplacizumab.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Sertraline.
Esomeprazole Injection Esomeprazole Injection The metabolism of Sertraline can be decreased when combined with Esomeprazole.
Alpelisib Alpelisib The serum concentration of Sertraline can be decreased when it is combined with Alpelisib.
Brexanolone Injection Brexanolone Injection The risk or severity of adverse effects can be increased when Brexanolone is combined with Sertraline.
Solriamfetol Solriamfetol The risk or severity of adverse effects can be increased when Solriamfetol is combined with Sertraline.
Triclabendazole Triclabendazole The metabolism of Triclabendazole can be decreased when combined with Sertraline.
Entrectinib Entrectinib The risk or severity of QTc prolongation can be increased when Sertraline is combined with Entrectinib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Sertraline.
Pitolisant Pitolisant The serum concentration of Sertraline can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The metabolism of Fedratinib can be decreased when combined with Sertraline.
Lefamulin Lefamulin Sertraline may increase the QTc-prolonging activities of Lefamulin.
Phenytoin Injection Phenytoin Injection The serum concentration of Phenytoin can be increased when it is combined with Sertraline.
Fosphenytoin Injection Fosphenytoin Injection The serum concentration of Fosphenytoin can be increased when it is combined with Sertraline.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Sertraline.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Sertraline.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Sertraline.
Lumateperone Lumateperone The risk or severity of adverse effects can be increased when Lumateperone is combined with Sertraline.
Lasmiditan Lasmiditan The risk or severity of serotonin syndrome can be increased when Lasmiditan is combined with Sertraline.
Cenobamate Cenobamate The serum concentration of Cenobamate can be decreased when it is combined with Sertraline.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Sertraline.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Sertraline.
Lemborexant Lemborexant The risk or severity of adverse effects can be increased when Lemborexant is combined with Sertraline.
Fenfluramine Fenfluramine The risk or severity of serotonin syndrome can be increased when Fenfluramine is combined with Sertraline.
Octreotide Octreotide The risk or severity of hypoglycemia can be increased when Octreotide is combined with Sertraline.
Pralsetinib Pralsetinib The metabolism of Sertraline can be decreased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Sertraline can be decreased when it is combined with Satralizumab.
Viloxazine Viloxazine The risk or severity of adverse effects can be increased when Sertraline is combined with Viloxazine.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Sertraline.
Fenoprofen Fenoprofen The risk or severity of bleeding can be increased when Sertraline is combined with Fenoprofen.
Indomethacin Indomethacin The risk or severity of bleeding can be increased when Sertraline is combined with Indomethacin.
Mefenamic Acid Mefenamic Acid The risk or severity of bleeding can be increased when Sertraline is combined with Mefenamic acid.
Naproxen Naproxen The risk or severity of bleeding can be increased when Sertraline is combined with Naproxen.
Tolmetin Tolmetin The risk or severity of bleeding can be increased when Sertraline is combined with Tolmetin.
Sulindac Sulindac The risk or severity of bleeding can be increased when Sertraline is combined with Sulindac.
Trazodone Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Sertraline.
Hydroxyurea Hydroxyurea The metabolism of Sertraline can be decreased when combined with Hydroxyurea.
Floxuridine Floxuridine The metabolism of Sertraline can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital The metabolism of Sertraline can be decreased when combined with Phenobarbital.
Metaxalone Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Sertraline.
Levorphanol Levorphanol The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Sertraline.
Primidone Primidone The risk or severity of adverse effects can be increased when Primidone is combined with Sertraline.
Methsuximide Methsuximide The risk or severity of adverse effects can be increased when Methsuximide is combined with Sertraline.
Diethylpropion Diethylpropion The risk or severity of adverse effects can be increased when Diethylpropion is combined with Sertraline.
Chlorpromazine Chlorpromazine The metabolism of Sertraline can be decreased when combined with Chlorpromazine.
Diazepam Diazepam The risk or severity of adverse effects can be increased when Diazepam is combined with Sertraline.
Oxazepam Oxazepam The risk or severity of adverse effects can be increased when Oxazepam is combined with Sertraline.
Flurazepam Flurazepam The risk or severity of adverse effects can be increased when Flurazepam is combined with Sertraline.
Clorazepate Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Sertraline.
Lorazepam Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Sertraline.
Amantadine Amantadine The risk or severity of serotonin syndrome can be increased when Amantadine is combined with Sertraline.
Codeine Codeine The risk or severity of serotonin syndrome can be increased when Codeine is combined with Sertraline.
Meprobamate Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Sertraline.
Chlordiazepoxide Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Sertraline.
Bromocriptine Bromocriptine The risk or severity of adverse effects can be increased when Bromocriptine is combined with Sertraline.
Tranylcypromine Tranylcypromine The risk or severity of serotonin syndrome can be increased when Tranylcypromine is combined with Sertraline.
Phenelzine Phenelzine The risk or severity of serotonin syndrome can be increased when Phenelzine is combined with Sertraline.
Procarbazine Procarbazine The risk or severity of serotonin syndrome can be increased when Procarbazine is combined with Sertraline.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Sertraline.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Sertraline.
Prochlorperazine Prochlorperazine The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Sertraline.
Thioridazine Thioridazine The metabolism of Sertraline can be decreased when combined with Thioridazine.
Trifluoperazine Trifluoperazine The risk or severity of adverse effects can be increased when Trifluoperazine is combined with Sertraline.
Dapsone Dapsone The metabolism of Dapsone can be decreased when combined with Sertraline.
Sulfadiazine Sulfadiazine The metabolism of Sertraline can be decreased when combined with Sulfadiazine.
Oxycodone Oxycodone The risk or severity of serotonin syndrome can be increased when Oxycodone is combined with Sertraline.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Sertraline.
Oxybutynin Oxybutynin The metabolism of Sertraline can be decreased when combined with Oxybutynin.
Benztropine Benztropine Sertraline may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
Maprotiline Maprotiline The risk or severity of adverse effects can be increased when Maprotiline is combined with Sertraline.
Ibuprofen Ibuprofen The risk or severity of bleeding can be increased when Sertraline is combined with Ibuprofen.
Trihexyphenidyl Trihexyphenidyl Sertraline may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine Orphenadrine Sertraline may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine Perphenazine The risk or severity of adverse effects can be increased when Perphenazine is combined with Sertraline.
Fluphenazine Fluphenazine The risk or severity of adverse effects can be increased when Fluphenazine is combined with Sertraline.
Phentermine Phentermine The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Sertraline.
Amoxapine Amoxapine The metabolism of Sertraline can be decreased when combined with Amoxapine.
Sulfasalazine Sulfasalazine The risk or severity of bleeding can be increased when Sertraline is combined with Sulfasalazine.
Doxorubicin Doxorubicin The metabolism of Sertraline can be decreased when combined with Doxorubicin.
Carbamazepine Carbamazepine The risk or severity of adverse effects can be increased when Carbamazepine is combined with Sertraline.
Molindone Molindone The risk or severity of adverse effects can be increased when Sertraline is combined with Molindone.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Sertraline.
Cimetidine Cimetidine The metabolism of Cimetidine can be decreased when combined with Sertraline.
Warfarin Warfarin The risk or severity of bleeding can be increased when Sertraline is combined with Warfarin.
Clonazepam Clonazepam The risk or severity of adverse effects can be increased when Clonazepam is combined with Sertraline.
Loperamide Loperamide The metabolism of Loperamide can be decreased when combined with Sertraline.
Promethazine Promethazine The metabolism of Sertraline can be decreased when combined with Promethazine.
Meclofenamate Meclofenamate The risk or severity of bleeding can be increased when Sertraline is combined with Meclofenamic acid.
Loxapine Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Sertraline.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Sertraline.
Quinine Quinine The metabolism of Quinine can be decreased when combined with Sertraline.
Ethosuximide Ethosuximide The therapeutic efficacy of Ethosuximide can be decreased when used in combination with Sertraline.
Sulfinpyrazone Sulfinpyrazone The risk or severity of bleeding can be increased when Sulfinpyrazone is combined with Sertraline.
Chlorothiazide Chlorothiazide The risk or severity of hyponatremia can be increased when Sertraline is combined with Chlorothiazide.
Chlorthalidone Chlorthalidone The risk or severity of hyponatremia can be increased when Sertraline is combined with Chlorthalidone.
Metolazone Metolazone The risk or severity of hyponatremia can be increased when Sertraline is combined with Metolazone.
Secobarbital Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Sertraline.
Desipramine Desipramine The metabolism of Desipramine can be decreased when combined with Sertraline.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Sertraline.
Imipramine Imipramine The metabolism of Sertraline can be decreased when combined with Imipramine.
Probenecid Probenecid The metabolism of Sertraline can be decreased when combined with Probenecid.
Quinidine Quinidine The metabolism of Quinidine can be decreased when combined with Sertraline.
Procainamide Procainamide The metabolism of Procainamide can be decreased when combined with Sertraline.
Isoniazid Isoniazid The metabolism of Sertraline can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Sertraline can be increased when combined with Rifampicin.
Disopyramide Disopyramide Sertraline may increase the central nervous system depressant (CNS depressant) activities of Disopyramide.
Valproic Acid Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Sertraline.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Sertraline.
Butabarbital Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Sertraline.
Levothyroxine Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Sertraline.
Liothyronine Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Sertraline.
Methimazole Methimazole The metabolism of Methimazole can be decreased when combined with Sertraline.
Propylthiouracil Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Sertraline.
Chlorpropamide Chlorpropamide The metabolism of Chlorpropamide can be decreased when combined with Sertraline.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Sertraline.
Tolazamide Tolazamide The metabolism of Tolazamide can be decreased when combined with Sertraline.
Dextromethorphan Dextromethorphan The risk or severity of adverse effects can be increased when Sertraline is combined with Dextromethorphan.
Cyclobenzaprine Cyclobenzaprine The risk or severity of CNS depression can be increased when Sertraline is combined with Cyclobenzaprine.
Niacin Niacin The metabolism of Sertraline can be decreased when combined with Niacin.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Sertraline.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Sertraline.
Cyproheptadine Cyproheptadine The therapeutic efficacy of Sertraline can be decreased when used in combination with Cyproheptadine.
Clemastine Clemastine The risk or severity of adverse effects can be increased when Sertraline is combined with Clemastine.
Chlorpheniramine Chlorpheniramine The risk or severity of adverse effects can be increased when Chlorpheniramine is combined with Sertraline.
Brompheniramine Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Sertraline.
Meclizine Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Sertraline.
Methyclothiazide Methyclothiazide The risk or severity of hyponatremia can be increased when Sertraline is combined with Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide The risk or severity of hyponatremia can be increased when Sertraline is combined with Hydrochlorothiazide.
Dantrolene Dantrolene The risk or severity of adverse effects can be increased when Dantrolene is combined with Sertraline.
Chlorzoxazone Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Sertraline.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Sertraline.
Methocarbamol Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Sertraline.
Disulfiram Disulfiram The risk or severity of adverse effects can be increased when Disulfiram is combined with Sertraline.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The serum concentration of Propranolol can be increased when it is combined with Sertraline.
Pseudoephedrine Pseudoephedrine The risk or severity of serotonin syndrome can be increased when Pseudoephedrine is combined with Sertraline.
Nortriptyline Nortriptyline The metabolism of Sertraline can be decreased when combined with Nortriptyline.
Nadolol Nadolol The serum concentration of Nadolol can be increased when it is combined with Sertraline.
Butorphanol Injection Butorphanol Injection The risk or severity of serotonin syndrome can be increased when Butorphanol is combined with Sertraline.
Nalbuphine Injection Nalbuphine Injection The risk or severity of serotonin syndrome can be increased when Nalbuphine is combined with Sertraline.
Trimethobenzamide Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Sertraline.
Flavoxate Flavoxate Sertraline may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Fluorouracil Injection Fluorouracil Injection The metabolism of Sertraline can be decreased when combined with Fluorouracil.
Acetazolamide Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Sertraline.
Calcitonin Salmon Injection Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Sertraline.
Ketoconazole Ketoconazole The metabolism of Sertraline can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel The risk or severity of adverse effects can be increased when Pyrantel is combined with Sertraline.
Dipyridamole Dipyridamole The risk or severity of bleeding can be increased when Sertraline is combined with Dipyridamole.
Vinblastine Vinblastine The metabolism of Sertraline can be decreased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Sertraline.
Hydroxyzine Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Sertraline.
Thiothixene Thiothixene The risk or severity of adverse effects can be increased when Sertraline is combined with Thiothixene.
Aspirin Aspirin The risk or severity of bleeding can be increased when Sertraline is combined with Acetylsalicylic acid.
Salsalate Salsalate The risk or severity of bleeding can be increased when Sertraline is combined with Salsalate.
Alprazolam Alprazolam The risk or severity of adverse effects can be increased when Alprazolam is combined with Sertraline.
Temazepam Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Sertraline.
Triazolam Triazolam The risk or severity of adverse effects can be increased when Triazolam is combined with Sertraline.
Dicyclomine Dicyclomine Sertraline may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine Hyoscyamine Sertraline may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline Propantheline Sertraline may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Trimethoprim Trimethoprim The metabolism of Trimethoprim can be decreased when combined with Sertraline.
Diltiazem Diltiazem The metabolism of Diltiazem can be decreased when combined with Sertraline.
Nifedipine Nifedipine The metabolism of Sertraline can be decreased when combined with Nifedipine.
Timolol Timolol The metabolism of Timolol can be decreased when combined with Sertraline.
Verapamil Verapamil The metabolism of Verapamil can be decreased when combined with Sertraline.
Atenolol Atenolol The serum concentration of Atenolol can be increased when it is combined with Sertraline.
Pindolol Pindolol The risk or severity of adverse effects can be increased when Pindolol is combined with Sertraline.
Cisplatin Injection Cisplatin Injection The metabolism of Sertraline can be decreased when combined with Cisplatin.
Diflunisal Diflunisal The risk or severity of bleeding can be increased when Sertraline is combined with Diflunisal.
Piroxicam Piroxicam The risk or severity of bleeding can be increased when Sertraline is combined with Piroxicam.
Glyburide Glyburide The metabolism of Sertraline can be decreased when combined with Glyburide.
Glipizide Glipizide The metabolism of Glipizide can be decreased when combined with Sertraline.
Indapamide Indapamide The risk or severity of hyponatremia can be increased when Sertraline is combined with Indapamide.
Pentoxifylline Pentoxifylline The risk or severity of bleeding can be increased when Sertraline is combined with Pentoxifylline.
Pentamidine Injection Pentamidine Injection The risk or severity of hypoglycemia can be increased when Sertraline is combined with Pentamidine.
Labetalol Labetalol The metabolism of Labetalol can be decreased when combined with Sertraline.
Gemfibrozil Gemfibrozil The metabolism of Sertraline can be decreased when combined with Gemfibrozil.
Ketoprofen Ketoprofen The risk or severity of bleeding can be increased when Ketoprofen is combined with Sertraline.
Pimozide Pimozide Sertraline may increase the arrhythmogenic activities of Pimozide.
Flurbiprofen Flurbiprofen The risk or severity of bleeding can be increased when Sertraline is combined with Flurbiprofen.
Amiodarone Amiodarone The metabolism of Sertraline can be decreased when combined with Amiodarone.
Buspirone Buspirone The risk or severity of serotonin syndrome can be increased when Sertraline is combined with Buspirone.
Lovastatin Lovastatin The metabolism of Sertraline can be decreased when combined with Lovastatin.
Mesalamine Mesalamine The risk or severity of bleeding can be increased when Sertraline is combined with Mesalazine.
Diclofenac Diclofenac The risk or severity of bleeding can be increased when Sertraline is combined with Diclofenac.
Fluoxetine Fluoxetine The serum concentration of Sertraline can be increased when it is combined with Fluoxetine.
Clozapine Clozapine The metabolism of Sertraline can be decreased when combined with Clozapine.
Estazolam Estazolam The risk or severity of adverse effects can be increased when Sertraline is combined with Estazolam.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Sertraline.
Etodolac Etodolac The risk or severity of bleeding can be increased when Sertraline is combined with Etodolac.
Felodipine Felodipine The metabolism of Sertraline can be decreased when combined with Felodipine.
Nabumetone Nabumetone The risk or severity of bleeding can be increased when Sertraline is combined with Nabumetone.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Sertraline.
Teniposide Injection Teniposide Injection The metabolism of Sertraline can be decreased when combined with Teniposide.
Oxaprozin Oxaprozin The risk or severity of bleeding can be increased when Sertraline is combined with Oxaprozin.
Atovaquone Atovaquone The metabolism of Sertraline can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Sertraline can be increased when combined with Rifabutin.
Sotalol Sotalol The metabolism of Sotalol can be decreased when combined with Sertraline.
Bisoprolol Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Sertraline.
Zolpidem Zolpidem Sertraline may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Sertraline.
Omeprazole Omeprazole The metabolism of Omeprazole can be decreased when combined with Sertraline.
Cisapride Cisapride The metabolism of Cisapride can be decreased when combined with Sertraline.
Gabapentin Gabapentin The risk or severity of adverse effects can be increased when Gabapentin is combined with Sertraline.
Fluvastatin Fluvastatin The metabolism of Sertraline can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The metabolism of Sertraline can be decreased when combined with Venlafaxine.
Fluvoxamine Fluvoxamine The metabolism of Sertraline can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The risk or severity of adverse effects can be increased when Sertraline is combined with Nefazodone.
Lamotrigine Lamotrigine The risk or severity of adverse effects can be increased when Lamotrigine is combined with Sertraline.
Losartan Losartan The metabolism of Losartan can be decreased when combined with Sertraline.
Tramadol Tramadol The risk or severity of serotonin syndrome can be increased when Sertraline is combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The metabolism of Sertraline can be decreased when combined with Vinorelbine.
Lansoprazole Lansoprazole The metabolism of Lansoprazole can be decreased when combined with Sertraline.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Sertraline.
Nicardipine Nicardipine The metabolism of Sertraline can be decreased when combined with Nicardipine.
Bupropion Bupropion The risk or severity of seizure can be increased when Sertraline is combined with Bupropion.
Ticlopidine Ticlopidine The risk or severity of bleeding can be increased when Ticlopidine is combined with Sertraline.
Saquinavir Saquinavir The metabolism of Sertraline can be decreased when combined with Saquinavir.
Metformin Metformin The risk or severity of hypoglycemia can be increased when Sertraline is combined with Metformin.
Dalteparin Injection Dalteparin Injection The risk or severity of bleeding can be increased when Sertraline is combined with Dalteparin.
Riluzole Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Sertraline.
Acarbose Acarbose The risk or severity of hypoglycemia can be increased when Acarbose is combined with Sertraline.
Glimepiride Glimepiride The metabolism of Glimepiride can be decreased when combined with Sertraline.
Ritonavir Ritonavir The serum concentration of Sertraline can be increased when it is combined with Ritonavir.
Clomipramine Clomipramine The metabolism of Sertraline can be decreased when combined with Clomipramine.
Zafirlukast Zafirlukast The metabolism of Sertraline can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine Sertraline may increase the serotonergic activities of Mirtazapine.
Topiramate Topiramate The risk or severity of adverse effects can be increased when Sertraline is combined with Topiramate.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Sertraline.
Valsartan Valsartan The metabolism of Sertraline can be decreased when combined with Valsartan.
Insulin Lispro Injection Insulin Lispro Injection The risk or severity of hypoglycemia can be increased when Insulin lispro is combined with Sertraline.
Pramipexole Pramipexole Sertraline may increase the sedative activities of Pramipexole.
Donepezil Donepezil The risk or severity of adverse effects can be increased when Donepezil is combined with Sertraline.
Nelfinavir Nelfinavir The metabolism of Sertraline can be decreased when combined with Nelfinavir.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Sertraline.
Nilutamide Nilutamide The metabolism of Sertraline can be decreased when combined with Nilutamide.
Selegiline Selegiline The risk or severity of serotonin syndrome can be increased when Selegiline is combined with Sertraline.
Bicalutamide Bicalutamide The metabolism of Sertraline can be decreased when combined with Bicalutamide.
Propafenone Propafenone Sertraline may increase the QTc-prolonging activities of Propafenone.
Letrozole Letrozole The metabolism of Sertraline can be decreased when combined with Letrozole.
Irbesartan Irbesartan The metabolism of Irbesartan can be decreased when combined with Sertraline.
Tamsulosin Tamsulosin The metabolism of Tamsulosin can be decreased when combined with Sertraline.
Ropinirole Ropinirole Sertraline may increase the sedative activities of Ropinirole.
Quetiapine Quetiapine The risk or severity of adverse effects can be increased when Sertraline is combined with Quetiapine.
Cetirizine Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Sertraline.
Paroxetine Paroxetine The metabolism of Sertraline can be decreased when combined with Paroxetine.
Tolcapone Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Sertraline.
Citalopram Citalopram The serum concentration of Citalopram can be increased when it is combined with Sertraline.
Capecitabine Capecitabine The metabolism of Sertraline can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The serum concentration of Sertraline can be decreased when it is combined with Efavirenz.
Sildenafil Sildenafil The metabolism of Sertraline can be decreased when combined with Sildenafil.
Pioglitazone Pioglitazone The risk or severity of hypoglycemia can be increased when Sertraline is combined with Pioglitazone.
Celecoxib Celecoxib The risk or severity of bleeding can be increased when Celecoxib is combined with Sertraline.
Rosiglitazone Rosiglitazone The metabolism of Rosiglitazone can be decreased when combined with Sertraline.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Sertraline.
Thalidomide Thalidomide Sertraline may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Balsalazide Balsalazide The risk or severity of bleeding can be increased when Sertraline is combined with Balsalazide.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Sertraline.
Galantamine Galantamine The metabolism of Galantamine can be decreased when combined with Sertraline.
Levetiracetam Levetiracetam The risk or severity of adverse effects can be increased when Levetiracetam is combined with Sertraline.
Rabeprazole Rabeprazole The metabolism of Sertraline can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Sertraline can be decreased when combined with Terbinafine.

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