Paroxetine

Paroxetine tablets, suspension (liquid), and extended-release (long-acting) tablets are used to treat depression, panic disorder (sudden, unexpected attacks of extreme fear and worry about these attacks), and social anxiety disorder (extreme fear of interacting with others or performing in front of others that interferes with normal life). Paroxetine tablets and suspension are also used to treat obsessive-compulsive disorder (bothersome thoughts that won't go away and the need to perform certain actions over and over), generalized anxiety disorder (GAD; excessive worrying that is difficult to control), and posttraumatic stress disorder (disturbing psychological symptoms that develop after a frightening experience). Paroxetine extended-release tablets are also used to treat premenstrual dysphoric disorder (PMDD, physical and psychological symptoms that occur before the onset of the menstrual period each month). Paroxetine capsules (Brisdelle) are used to treat hot flashes (sudden feelings of warmth, especially in the face, neck, and chest) in women who are experiencing menopause (stage of life when menstrual periods become less frequent and stop and women may experience other symptoms and body changes). Paroxetine is in a class of medications called selective serotonin-reuptake inhibitors (SSRIs). It treats depression and other mental illnesses by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance. There is not enough information available at this time to know how paroxetine works to treat hot flashes.

Paroxetine comes as a tablet, a suspension (liquid), a controlled-release (long-acting) tablet, and a capsule to take by mouth. The tablets, suspension, and controlled-release tablets are usually taken once daily in the morning or evening, with or without food. The capsules are usually taken once a day at bedtime with or without food. You may want to take paroxetine with food to prevent stomach upset. Take paroxetine at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take paroxetine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the liquid well before each use to mix the medication evenly.

Swallow the extended-release and regular tablets whole; do not chew or crush them.

If you are taking paroxetine tablets, suspension, or controlled-release tablets, your doctor may start you on a low dose of paroxetine and gradually increase your dose, not more than once a week.

Paroxetine capsules contain a lower dose of paroxetine than is needed to treat depression and other forms of mental illness. Do not take paroxetine capsules to treat a mental illness. If you think you have depression or another mental illness, talk to your doctor about treatment.

Paroxetine may help control your symptoms but will not cure your condition. It may take several weeks or longer before you feel the full benefit of paroxetine. Continue to take paroxetine even if you feel well. Do not stop taking paroxetine without talking to your doctor. Your doctor may decrease your dose gradually. If you suddenly stop taking paroxetine tablets, suspension, or controlled-release tablets, you may experience withdrawal symptoms such as depression; mood changes; frenzied or abnormally excited mood; irritability; anxiety; confusion; dizziness; headache; tiredness; numbness or tingling in the arms, legs, hands, or feet; unusual dreams; difficulty falling asleep or staying asleep; nausea; or sweating. Tell your doctor if you experience any of these symptoms when your dose of paroxetine is decreased.

Paroxetine is also sometimes used to treat chronic headaches, tingling, pain, or numbness in the hands and feet caused by diabetes, and certain male sexual problems. Paroxetine is also used with other medications to treat bipolar disorder (mood that changes from depressed to abnormally excited). Talk to your doctor about the possible risks of using this drug for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking paroxetine,

• tell your doctor and pharmacist if you are allergic to paroxetine, any other medications, or any of the ingredients in paroxetine tablets, controlled-release tablets, capsules, or suspension. Ask your pharmacist or check the Medication Guide for a list of the ingredients

• tell your doctor if you are taking monoamine oxidase (MAO) inhibitors, including isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Emsam, Zelapar), and tranylcypromine (Parnate); if you have stopped taking them within the past 2 weeks; or if you are taking thioridazine or pimozide (Orap). Your doctor will probably tell you not to take paroxetine. If you stop taking paroxetine, you should wait at least 2 weeks before you start to take an MAO inhibitor.

• tell your doctor and pharmacist what other prescription and nonprescription medications and vitamins you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven) and heparin; antidepressants ('mood elevators') such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin, imipramine (Tofranil), nortriptyline (Pamelor), protriptyline, and trimipramine; antihistamines; aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin), and naproxen (Aleve, Naprosyn); atomoxetine (Straterra); buspirone (Buspar); chlorpromazine (Thorazine); cimetidine (Tagamet); clopidogrel (Plavix); dextromethorphan (found in many cough medications; in Nuedexta); digoxin (Lanoxin); dipyridamole (Persantine); diuretics ('water pills'); fentanyl (Actiq, Fentora, Lazanda, others); fosamprenavir (Lexiva); haloperidol (Haldol); isoniazid (INH, Nydrazid); lithium (Lithobid); medications for irregular heartbeat such as flecainide or propafenone (Rythmol); medications for mental illness and nausea; medications for migraine headaches such as almotriptan, eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); medications for seizures such as phenobarbital and phenytoin (Dilantin);metoprolol (Lopressor, Toprol XL); other selective serotonin-reuptake inhibitors such as citalopram (Celexa), fluoxetine (Prozac), fluvoxamine (Luvox), and sertraline (Zoloft); propranolol (Inderal); risperidone (Risperdal); ritonavir (Norvir); serotonin–norepinephrine reuptake inhibitors (SNRI) medications such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), levomilnacipran (Fetzima), and venlafaxine; tamoxifen (Soltamox); theophylline (Theobid, Theo-Dur); tramadol (Conzip, Qdolo,Ultram, in Ultracet); and trazodone. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with paroxetine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

• you should know that paroxetine products that have different brand names are available and are used to treat different conditions. Do not take more than one product that contains paroxetine at a time.

• tell your doctor what herbal products and nutritional supplements you are taking, especially St. John's wort and tryptophan.

• tell your doctor if you use or have ever used street drugs or have overused prescription medications, if you have recently had a heart attack, and if you have a low level of sodium in your blood. Also tell your doctor if you have or have ever had seizures; glaucoma; bleeding problems; bone problems including osteoporosis (a condition in which the bones become thin and weak and break easily) or bone fractures; or liver, kidney, or heart disease.

• tell your doctor if you are pregnant, if you plan to become pregnant, or if you are breastfeeding. If you become pregnant while taking paroxetine, call your doctor immediately. Paroxetine may cause heart defects in the fetus if it is taken during early pregnancy and problems in newborns following delivery if it is taken during the last months of pregnancy.

• talk to your doctor about the risks and benefits of taking paroxetine if you are 65 years of age or older. Older adults should not usually take paroxetine because it is not as safe or effective as other medications that can be used to treat the same condition.

• if you are having surgery, including dental surgery tell the doctor or dentist that you are taking paroxetine.

• you should know that paroxetine may make you drowsy and affect your judgment and thinking. Do not drive a car or operate machinery until you know how this medication affects you.

• ask your doctor about the safe use of alcoholic beverages while you are taking paroxetine.

• you should know that paroxetine may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Paroxetine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache

  • dizziness

  • weakness

  • difficulty concentrating

  • nervousness

  • forgetfulness

  • confusion

  • sleepiness

  • nausea

  • vomiting

  • diarrhea

  • constipation

  • gas

  • stomach pain

  • heartburn

  • changes in ability to taste food

  • decreased appetite

  • weight loss or gain

  • sexual problems in males; decreased sex drive, inability to get or keep an erection, or delayed or absent ejaculation

  • sexual problems in females; decreased sex drive, or delayed orgasm or unable to have an orgasm

  • dry mouth

  • sweating

  • yawning

  • pain in the back, muscles, bones, or anywhere in the body

  • tenderness or swelling of joints

• Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS sections, call your doctor immediately or get emergency medical treatment:

  • seeing things or hearing voices that do not exist (hallucinating)

  • fainting

  • rapid, pounding, or irregular heartbeat

  • chest pain

  • difficulty breathing

  • seizures

  • agitation, fever, sweating, confusion, fast or irregular heartbeat, and severe muscle stiffness or twitching, hallucinations, loss of coordination, nausea, vomiting, or diarrhea

  • abnormal bleeding or bruising

  • tiny red spots directly under the skin

  • peeling or blistering of skin

  • sore throat, fever, chills, cough, and other signs of infection

  • uncontrollable shaking of a part of the body

  • unsteady walking that may cause falling

  • numbness or tingling in your hands, feet, arms, or legs

  • painful erection that lasts for hours

  • sudden nausea, vomiting, weakness, cramping, bloating, swelling, tightness in hands and feet, dizziness, headache and/or confusion

  • hives

  • rash

  • itching

  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

  • hoarseness

  • black and tarry stools

  • red blood in stools

  • bloody vomit

  • vomit that looks like coffee grounds

  • bone pain or fracture

  • tenderness, swelling, or bruising of one part of your body

• Paroxetine may decrease appetite and cause weight loss in children. Your child's doctor will watch his or her growth carefully. Talk to your child's doctor if you have concerns about your child's growth or weight while he or she is taking this medication. Talk to your child's doctor about the risks of giving paroxetine to your child.

• Paroxetine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

• drowsiness

• coma

• seizures

• fever, sweating, confusion, fast or irregular heartbeat, and severe muscle stiffness or twitching

• nausea, vomiting, diarrhea

• aggressive behavior

• dark red or brown urine

• frenzied, abnormally excited mood

Keep all appointments with your doctor.

Before having any laboratory test (especially those that involve methylene blue), tell your doctor and the laboratory personnel that you are taking paroxetine.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Moxifloxacin	Moxifloxacin The metabolism of Paroxetine can be decreased when combined with Moxifloxacin.
Repaglinide	Repaglinide The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Repaglinide.
Montelukast	Montelukast The metabolism of Montelukast can be decreased when combined with Paroxetine.
Insulin Glargine (rDNA origin) Injection	Insulin Glargine (rDNA origin) Injection The metabolism of Paroxetine can be increased when combined with Insulin glargine.
Delavirdine	Delavirdine The metabolism of Paroxetine can be decreased when combined with Delavirdine.
Nevirapine	Nevirapine The metabolism of Nevirapine can be decreased when combined with Paroxetine.
Atorvastatin	Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Paroxetine.
Dolasetron	Dolasetron The metabolism of Dolasetron can be decreased when combined with Paroxetine.
Aminophylline	Aminophylline The metabolism of Aminophylline can be decreased when combined with Paroxetine.
Anagrelide	Anagrelide The risk or severity of hemorrhage can be increased when Paroxetine is combined with Anagrelide.
Bisacodyl	Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Paroxetine.
Candesartan	Candesartan The metabolism of Candesartan can be decreased when combined with Paroxetine.
Cilostazol	Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Paroxetine.
Clopidogrel	Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Paroxetine.
Diphenoxylate	Diphenoxylate The risk or severity of serotonin syndrome can be increased when Diphenoxylate is combined with Paroxetine.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) The metabolism of Paroxetine can be decreased when combined with Conjugated estrogens.
Fenofibrate	Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Paroxetine.
Guanfacine	Guanfacine The risk or severity of adverse effects can be increased when Guanfacine is combined with Paroxetine.
Magnesium Hydroxide	Magnesium Hydroxide The therapeutic efficacy of Magnesium hydroxide can be decreased when used in combination with Paroxetine.
Magnesium Oxide	Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Paroxetine.
Miglitol	Miglitol The risk or severity of hypoglycemia can be increased when Miglitol is combined with Paroxetine.
Naratriptan	Naratriptan The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Naratriptan.
Olsalazine	Olsalazine The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Olsalazine.
Paregoric	Paregoric The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Morphine.
Penbutolol	Penbutolol The metabolism of Acebutolol can be decreased when combined with Paroxetine.
Pentazocine	Pentazocine The risk or severity of serotonin syndrome can be increased when Pentazocine is combined with Paroxetine.
Polyethylene glycol-electrolyte solution (PEG-ES)	Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Paroxetine.
Psyllium	Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Paroxetine.
Ranitidine	Ranitidine The metabolism of Ranitidine can be decreased when combined with Paroxetine.
Reserpine	Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Paroxetine.
Rizatriptan	Rizatriptan The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Rizatriptan.
Sumatriptan	Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Paroxetine.
Tacrolimus	Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Paroxetine.
Tizanidine	Tizanidine The risk or severity of adverse effects can be increased when Paroxetine is combined with Tizanidine.
Zolmitriptan	Zolmitriptan The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Zolmitriptan.
Famotidine Injection	Famotidine Injection The metabolism of Paroxetine can be decreased when combined with Famotidine.
Fluconazole Injection	Fluconazole Injection The metabolism of Paroxetine can be decreased when combined with Fluconazole.
Hydromorphone Injection	Hydromorphone Injection The risk or severity of serotonin syndrome can be increased when Hydromorphone is combined with Paroxetine.
Interferon Beta-1b Injection	Interferon Beta-1b Injection The metabolism of Paroxetine can be decreased when combined with Interferon beta-1b.
Interferon Gamma-1b Injection	Interferon Gamma-1b Injection The metabolism of Paroxetine can be decreased when combined with Interferon gamma-1b.
Levofloxacin Injection	Levofloxacin Injection The metabolism of Paroxetine can be decreased when combined with Levofloxacin.
Meperidine Injection	Meperidine Injection The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Meperidine.
Metoclopramide Injection	Metoclopramide Injection The risk or severity of sedation can be increased when Metoclopramide is combined with Paroxetine.
Morphine Injection	Morphine Injection The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Morphine.
Zidovudine Injection	Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Paroxetine.
Altretamine	Altretamine Paroxetine may increase the serotonergic activities of Amphetamine.
Cyclosporine	Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Paroxetine.
Ondansetron	Ondansetron The metabolism of Ondansetron can be decreased when combined with Paroxetine.
Enoxaparin Injection	Enoxaparin Injection The risk or severity of hemorrhage can be increased when Paroxetine is combined with Enoxaparin.
Granisetron	Granisetron The risk or severity of adverse effects can be increased when Granisetron is combined with Paroxetine.
Torsemide	Torsemide The metabolism of Paroxetine can be decreased when combined with Torasemide.
Olanzapine	Olanzapine The metabolism of Paroxetine can be decreased when combined with Olanzapine.
Alosetron	Alosetron The risk or severity of adverse effects can be increased when Alosetron is combined with Paroxetine.
Dofetilide	Dofetilide The metabolism of Dofetilide can be decreased when combined with Paroxetine.
Entacapone	Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Paroxetine.
Hydroxychloroquine	Hydroxychloroquine The metabolism of Paroxetine can be decreased when combined with Hydroxychloroquine.
Meloxicam	Meloxicam The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Meloxicam.
Oxcarbazepine	Oxcarbazepine The risk or severity of adverse effects can be increased when Oxcarbazepine is combined with Paroxetine.
Pantoprazole	Pantoprazole The metabolism of Paroxetine can be decreased when combined with Pantoprazole.
Telmisartan	Telmisartan The metabolism of Paroxetine can be decreased when combined with Telmisartan.
Zaleplon	Zaleplon The risk or severity of adverse effects can be increased when Zaleplon is combined with Paroxetine.
Anakinra	Anakinra The metabolism of Paroxetine can be increased when combined with Anakinra.
Desloratadine	Desloratadine The risk or severity of adverse effects can be increased when Paroxetine is combined with Desloratadine.
Linezolid	Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Paroxetine.
Pentosan Polysulfate	Pentosan Polysulfate The risk or severity of hemorrhage can be increased when Paroxetine is combined with Pentosan polysulfate.
Rivastigmine	Rivastigmine The therapeutic efficacy of Paroxetine can be decreased when used in combination with Rivastigmine.
Trimipramine	Trimipramine The metabolism of Paroxetine can be decreased when combined with Trimipramine.
Etanercept Injection	Etanercept Injection The metabolism of Paroxetine can be increased when combined with Etanercept.
Glycopyrrolate	Glycopyrrolate The risk or severity of adverse effects can be increased when Paroxetine is combined with Glycopyrronium.
Modafinil	Modafinil The metabolism of Paroxetine can be decreased when combined with Armodafinil.
Tenofovir	Tenofovir The metabolism of Tenofovir can be decreased when combined with Paroxetine.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Choline magnesium trisalicylate.
Sirolimus	Sirolimus The metabolism of Sirolimus can be decreased when combined with Paroxetine.
Epinephrine Injection	Epinephrine Injection The risk or severity of Tachycardia can be increased when Epinephrine is combined with Paroxetine.
Escitalopram	Escitalopram The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Escitalopram.
Zonisamide	Zonisamide The risk or severity of adverse effects can be increased when Zonisamide is combined with Paroxetine.
Adalimumab Injection	Adalimumab Injection The metabolism of Paroxetine can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Paroxetine.
Atomoxetine	Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Paroxetine.
Dexmethylphenidate	Dexmethylphenidate The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with Paroxetine.
Teriparatide Injection	Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Paroxetine.
Atazanavir	Atazanavir The metabolism of Atazanavir can be decreased when combined with Paroxetine.
Almotriptan	Almotriptan The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Almotriptan.
Eletriptan	Eletriptan The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Eletriptan.
Mefloquine	Mefloquine The therapeutic efficacy of Paroxetine can be decreased when used in combination with Mefloquine.
Polyethylene Glycol 3350	Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Paroxetine.
Rosuvastatin	Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Paroxetine.
Vardenafil	Vardenafil The metabolism of Vardenafil can be decreased when combined with Paroxetine.
Alfuzosin	Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Paroxetine.
Aprepitant	Aprepitant The metabolism of Paroxetine can be decreased when combined with Aprepitant.
Interferon Beta-1a Subcutaneous Injection	Interferon Beta-1a Subcutaneous Injection The metabolism of Paroxetine can be decreased when combined with Interferon beta-1a.
Memantine	Memantine The metabolism of Paroxetine can be decreased when combined with Memantine.
Tegaserod	Tegaserod The metabolism of Tegaserod can be decreased when combined with Paroxetine.
Fosamprenavir	Fosamprenavir The serum concentration of Paroxetine can be decreased when it is combined with Fosamprenavir.
Frovatriptan	Frovatriptan The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Frovatriptan.
Gemifloxacin	Gemifloxacin The metabolism of Paroxetine can be decreased when combined with Gemifloxacin.
Progesterone	Progesterone The metabolism of Progesterone can be decreased when combined with Paroxetine.
Apomorphine Injection	Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Paroxetine.
Infliximab Injection	Infliximab Injection The metabolism of Paroxetine can be increased when combined with Infliximab.
Protriptyline	Protriptyline The metabolism of Paroxetine can be decreased when combined with Protriptyline.
Rifaximin	Rifaximin The metabolism of Paroxetine can be increased when combined with Rifaximin.
Duloxetine	Duloxetine The metabolism of Paroxetine can be decreased when combined with Duloxetine.
Norethindrone	Norethindrone The metabolism of Norethisterone can be decreased when combined with Paroxetine.
Trospium	Trospium Paroxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan	Bosentan The metabolism of Bosentan can be decreased when combined with Paroxetine.
Cinacalcet	Cinacalcet The metabolism of Paroxetine can be decreased when combined with Cinacalcet.
Erlotinib	Erlotinib The metabolism of Erlotinib can be decreased when combined with Paroxetine.
Eszopiclone	Eszopiclone The risk or severity of CNS depression can be increased when Paroxetine is combined with Eszopiclone.
Insulin Aspart (rDNA Origin) Injection	Insulin Aspart (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Insulin aspart.
Solifenacin	Solifenacin The metabolism of Solifenacin can be decreased when combined with Paroxetine.
Voriconazole	Voriconazole The metabolism of Paroxetine can be decreased when combined with Voriconazole.
Dextroamphetamine	Dextroamphetamine Paroxetine may increase the serotonergic activities of Amphetamine.
Entecavir	Entecavir The metabolism of Paroxetine can be decreased when combined with Entecavir.
Peginterferon Alfa-2a Injection	Peginterferon Alfa-2a Injection The metabolism of Paroxetine can be decreased when combined with Peginterferon alfa-2a.
Peginterferon Alfa-2b (PEG-Intron)	Peginterferon Alfa-2b (PEG-Intron) The serum concentration of Paroxetine can be increased when it is combined with Peginterferon alfa-2b.
Pramlintide Injection	Pramlintide Injection The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Paroxetine.
Sodium Oxybate	Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Paroxetine.
Exenatide Injection	Exenatide Injection The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Exenatide.
Isocarboxazid	Isocarboxazid Paroxetine may increase the serotonergic activities of Isocarboxazid.
Ramelteon	Ramelteon The risk or severity of adverse effects can be increased when Ramelteon is combined with Paroxetine.
Darifenacin	Darifenacin The metabolism of Darifenacin can be decreased when combined with Paroxetine.
Fentanyl	Fentanyl The metabolism of Fentanyl can be decreased when combined with Paroxetine.
Pregabalin	Pregabalin The therapeutic efficacy of Paroxetine can be increased when used in combination with Pregabalin.
Deferasirox	Deferasirox The serum concentration of Paroxetine can be increased when it is combined with Deferasirox.
Phenylephrine	Phenylephrine The metabolism of Paroxetine can be increased when combined with Phenylephrine.
Tipranavir	Tipranavir The metabolism of Tipranavir can be decreased when combined with Paroxetine.
Felbamate	Felbamate The risk or severity of adverse effects can be increased when Felbamate is combined with Paroxetine.
Insulin Detemir (rDNA Origin) Injection	Insulin Detemir (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Insulin detemir.
Ranolazine	Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Paroxetine.
Abatacept Injection	Abatacept Injection The metabolism of Paroxetine can be increased when combined with Abatacept.
Rasagiline	Rasagiline Rasagiline may increase the serotonergic activities of Paroxetine.
Imatinib	Imatinib The metabolism of Imatinib can be decreased when combined with Paroxetine.
Sitagliptin	Sitagliptin The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Sitagliptin.
Gefitinib	Gefitinib The metabolism of Gefitinib can be decreased when combined with Paroxetine.
Albuterol	Albuterol The risk or severity of Tachycardia can be increased when Paroxetine is combined with Salbutamol.
Paliperidone	Paliperidone The metabolism of Paliperidone can be decreased when combined with Paroxetine.
Bortezomib	Bortezomib The metabolism of Bortezomib can be decreased when combined with Paroxetine.
Insulin Glulisine (rDNA origin) Injection	Insulin Glulisine (rDNA origin) Injection The metabolism of Paroxetine can be increased when combined with Insulin glulisine.
Lubiprostone	Lubiprostone The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Paroxetine.
Primaquine	Primaquine The metabolism of Paroxetine can be decreased when combined with Primaquine.
Darunavir	Darunavir The serum concentration of Paroxetine can be decreased when it is combined with Darunavir.
Pemetrexed Injection	Pemetrexed Injection The metabolism of Paroxetine can be decreased when combined with Pemetrexed.
Dimenhydrinate	Dimenhydrinate The risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Paroxetine.
Lisdexamfetamine	Lisdexamfetamine The metabolism of Lisdexamfetamine can be decreased when combined with Paroxetine.
Nabilone	Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Paroxetine.
Retapamulin	Retapamulin The metabolism of Retapamulin can be decreased when combined with Paroxetine.
Sorafenib	Sorafenib The metabolism of Paroxetine can be decreased when combined with Sorafenib.
Sunitinib	Sunitinib The metabolism of Sunitinib can be decreased when combined with Paroxetine.
Dronabinol	Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Paroxetine.
Lapatinib	Lapatinib The metabolism of Lapatinib can be decreased when combined with Paroxetine.
Levocetirizine	Levocetirizine The risk or severity of adverse effects can be increased when Levocetirizine is combined with Paroxetine.
Dasatinib	Dasatinib The metabolism of Dasatinib can be decreased when combined with Paroxetine.
Mexiletine	Mexiletine The metabolism of Mexiletine can be decreased when combined with Paroxetine.
Armodafinil	Armodafinil The metabolism of Paroxetine can be decreased when combined with Armodafinil.
Paclitaxel (with polyoxyethylated castor oil) Injection	Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Paroxetine.
Temsirolimus	Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Paroxetine.
Nilotinib	Nilotinib The metabolism of Nilotinib can be decreased when combined with Paroxetine.
Bexarotene	Bexarotene The metabolism of Bexarotene can be decreased when combined with Paroxetine.
Chloramphenicol Injection	Chloramphenicol Injection The metabolism of Paroxetine can be decreased when combined with Chloramphenicol.
Desmopressin	Desmopressin The risk or severity of hyponatremia can be increased when Paroxetine is combined with Desmopressin.
Betaine	Betaine The therapeutic efficacy of Paroxetine can be decreased when used in combination with Glycine betaine.
OnabotulinumtoxinA Injection	OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Paroxetine is combined with Botulinum toxin type A.
RimabotulinumtoxinB Injection	RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Paroxetine is combined with Botulinum Toxin Type B.
Etravirine	Etravirine The metabolism of Etravirine can be decreased when combined with Paroxetine.
Desvenlafaxine	Desvenlafaxine The risk or severity of adverse effects can be increased when Paroxetine is combined with Desvenlafaxine.
Cevimeline	Cevimeline The metabolism of Cevimeline can be decreased when combined with Paroxetine.
Nebivolol	Nebivolol The metabolism of Nebivolol can be decreased when combined with Paroxetine.
Tretinoin	Tretinoin The metabolism of Tretinoin can be decreased when combined with Paroxetine.
Bendamustine Injection	Bendamustine Injection The metabolism of Bendamustine can be decreased when combined with Paroxetine.
Flecainide	Flecainide The metabolism of Flecainide can be decreased when combined with Paroxetine.
Certolizumab Injection	Certolizumab Injection The metabolism of Paroxetine can be increased when combined with Certolizumab pegol.
Ixabepilone Injection	Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Paroxetine.
Irinotecan Injection	Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Paroxetine.
Praziquantel	Praziquantel The metabolism of Praziquantel can be decreased when combined with Paroxetine.
Rufinamide	Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Paroxetine.
Midazolam	Midazolam The serum concentration of Midazolam can be increased when it is combined with Paroxetine.
Naltrexone Injection	Naltrexone Injection The risk or severity of adverse effects can be increased when Naltrexone is combined with Paroxetine.
Eltrombopag	Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Paroxetine.
Milnacipran	Milnacipran The risk or severity of adverse effects can be increased when Paroxetine is combined with Milnacipran.
Dexlansoprazole	Dexlansoprazole The metabolism of Paroxetine can be decreased when combined with Dexlansoprazole.
Sodium Phosphate	Sodium Phosphate The therapeutic efficacy of Sodium phosphate, monobasic can be decreased when used in combination with Paroxetine.
Fesoterodine	Fesoterodine The metabolism of Fesoterodine can be decreased when combined with Paroxetine.
Betaxolol	Betaxolol The metabolism of Betaxolol can be decreased when combined with Paroxetine.
Iloperidone	Iloperidone The metabolism of Iloperidone can be decreased when combined with Paroxetine.
Prasugrel	Prasugrel The risk or severity of hemorrhage can be increased when Paroxetine is combined with Prasugrel.
Lacosamide	Lacosamide The risk or severity of adverse effects can be increased when Lacosamide is combined with Paroxetine.
Everolimus	Everolimus The metabolism of Everolimus can be decreased when combined with Paroxetine.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) The metabolism of Tolvaptan can be decreased when combined with Paroxetine.
Dronedarone	Dronedarone The metabolism of Dronedarone can be decreased when combined with Paroxetine.
AbobotulinumtoxinA Injection	AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Paroxetine is combined with Botulinum toxin type A.
Palonosetron Injection	Palonosetron Injection The metabolism of Palonosetron can be decreased when combined with Paroxetine.
Saxagliptin	Saxagliptin The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Saxagliptin.
Romidepsin Injection	Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Paroxetine.
Tapentadol	Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Paroxetine.
Golimumab Injection	Golimumab Injection The metabolism of Paroxetine can be increased when combined with Golimumab.
Pazopanib	Pazopanib The metabolism of Pazopanib can be decreased when combined with Paroxetine.
Asenapine	Asenapine The risk or severity of adverse effects can be increased when Paroxetine is combined with Asenapine.
Vigabatrin	Vigabatrin The risk or severity of adverse effects can be increased when Vigabatrin is combined with Paroxetine.
Pitavastatin	Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Paroxetine.
Albendazole	Albendazole The metabolism of Albendazole can be decreased when combined with Paroxetine.
Oxymorphone	Oxymorphone The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Oxymorphone.
Dabigatran	Dabigatran The risk or severity of hemorrhage can be increased when Paroxetine is combined with Dabigatran.
Liraglutide Injection	Liraglutide Injection The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Liraglutide.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Paroxetine can be increased when combined with Tocilizumab.
IncobotulinumtoxinA Injection	IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Paroxetine is combined with Botulinum toxin type A.
Cabazitaxel Injection	Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Paroxetine.
Lurasidone	Lurasidone The risk or severity of adverse effects can be increased when Lurasidone is combined with Paroxetine.
Acetaminophen Injection	Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Paroxetine.
Vilazodone	Vilazodone The metabolism of Vilazodone can be decreased when combined with Paroxetine.
Terbutaline Injection	Terbutaline Injection The therapeutic efficacy of Paroxetine can be decreased when used in combination with Terbutaline.
Busulfan Injection	Busulfan Injection The metabolism of Busulfan can be decreased when combined with Paroxetine.
Roflumilast	Roflumilast The metabolism of Roflumilast can be decreased when combined with Paroxetine.
Linagliptin	Linagliptin The metabolism of Linagliptin can be decreased when combined with Paroxetine.
Rilpivirine	Rilpivirine The metabolism of Paroxetine can be decreased when combined with Rilpivirine.
Potassium Iodide	Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Paroxetine.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Paroxetine.
Abiraterone	Abiraterone The serum concentration of Paroxetine can be increased when it is combined with Abiraterone.
Rivaroxaban	Rivaroxaban The risk or severity of hemorrhage can be increased when Paroxetine is combined with Rivaroxaban.
Ticagrelor	Ticagrelor The risk or severity of hemorrhage can be increased when Paroxetine is combined with Ticagrelor.
Brentuximab Vedotin Injection	Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be decreased when combined with Paroxetine.
Ruxolitinib	Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Paroxetine.
Vandetanib	Vandetanib The metabolism of Vandetanib can be decreased when combined with Paroxetine.
Clobazam	Clobazam The metabolism of Paroxetine can be decreased when combined with Clobazam.
Vemurafenib	Vemurafenib The serum concentration of Paroxetine can be increased when it is combined with Vemurafenib.
Vismodegib	Vismodegib The metabolism of Vismodegib can be decreased when combined with Paroxetine.
Axitinib	Axitinib The metabolism of Axitinib can be decreased when combined with Paroxetine.
Crizotinib	Crizotinib The metabolism of Crizotinib can be decreased when combined with Paroxetine.
Cabergoline	Cabergoline The metabolism of Paroxetine can be decreased when combined with Cabergoline.
Fondaparinux Injection	Fondaparinux Injection The risk or severity of hemorrhage can be increased when Paroxetine is combined with Fondaparinux.
Ezogabine	Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Paroxetine.
Iloprost	Iloprost The risk or severity of hemorrhage can be increased when Paroxetine is combined with Iloprost.
Enzalutamide	Enzalutamide The metabolism of Paroxetine can be increased when combined with Enzalutamide.
Mirabegron	Mirabegron The risk or severity of urinary retention can be increased when Paroxetine is combined with Mirabegron.
Regorafenib	Regorafenib The metabolism of Regorafenib can be decreased when combined with Paroxetine.
Bosutinib	Bosutinib The metabolism of Bosutinib can be decreased when combined with Paroxetine.
Linaclotide	Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Paroxetine.
Teriflunomide	Teriflunomide The serum concentration of Paroxetine can be decreased when it is combined with Teriflunomide.
Lorcaserin	Lorcaserin The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Mecasermin.
Cabozantinib (thyroid cancer)	Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Paroxetine.
Icosapent Ethyl	Icosapent Ethyl The risk or severity of hemorrhage can be increased when Paroxetine is combined with Icosapent ethyl.
Tofacitinib	Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Paroxetine.
Alogliptin	Alogliptin The metabolism of Alogliptin can be decreased when combined with Paroxetine.
Ponatinib	Ponatinib The metabolism of Ponatinib can be decreased when combined with Paroxetine.
Pomalidomide	Pomalidomide The metabolism of Paroxetine can be decreased when combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Paroxetine.
Apixaban	Apixaban The risk or severity of hemorrhage can be increased when Paroxetine is combined with Apixaban.
Canagliflozin	Canagliflozin The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Canagliflozin.
Dabrafenib	Dabrafenib The serum concentration of Paroxetine can be decreased when it is combined with Dabrafenib.
Ospemifene	Ospemifene The metabolism of Ospemifene can be decreased when combined with Paroxetine.
Levomilnacipran	Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Paroxetine.
Vortioxetine	Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Paroxetine.
Perampanel	Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Paroxetine.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Paroxetine.
Lomitapide	Lomitapide The metabolism of Lomitapide can be decreased when combined with Paroxetine.
Ketorolac Injection	Ketorolac Injection The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Ketorolac.
Simeprevir	Simeprevir The metabolism of Paroxetine can be decreased when combined with Simeprevir.
Dapagliflozin	Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Paroxetine.
Apremilast	Apremilast The metabolism of Paroxetine can be increased when combined with Apremilast.
Droxidopa	Droxidopa The risk or severity of Tachycardia can be increased when Paroxetine is combined with Droxidopa.
Ceritinib	Ceritinib The metabolism of Ceritinib can be decreased when combined with Paroxetine.
Siltuximab Injection	Siltuximab Injection The metabolism of Paroxetine can be increased when combined with Siltuximab.
Albiglutide Injection	Albiglutide Injection The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Albiglutide.
Eslicarbazepine	Eslicarbazepine The risk or severity of adverse effects can be increased when Eslicarbazepine is combined with Paroxetine.
Belinostat Injection	Belinostat Injection The metabolism of Paroxetine can be increased when combined with Belinostat.
Idelalisib	Idelalisib The metabolism of Idelalisib can be decreased when combined with Paroxetine.
Testosterone Injection	Testosterone Injection The metabolism of Testosterone can be decreased when combined with Paroxetine.
Oritavancin Injection	Oritavancin Injection The metabolism of Paroxetine can be decreased when combined with Oritavancin.
Empagliflozin	Empagliflozin The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Empagliflozin.
Vorapaxar	Vorapaxar The risk or severity of hemorrhage can be increased when Paroxetine is combined with Vorapaxar.
Hydrocodone	Hydrocodone Paroxetine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Suvorexant	Suvorexant Paroxetine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Dulaglutide Injection	Dulaglutide Injection The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Dulaglutide.
Edoxaban	Edoxaban The risk or severity of hemorrhage can be increased when Paroxetine is combined with Edoxaban.
Peginterferon Beta-1a Injection	Peginterferon Beta-1a Injection The metabolism of Paroxetine can be decreased when combined with Peginterferon beta-1a.
Olaparib	Olaparib The metabolism of Olaparib can be decreased when combined with Paroxetine.
Methamphetamine	Methamphetamine The metabolism of Metamfetamine can be decreased when combined with Paroxetine.
Tasimelteon	Tasimelteon The risk or severity of adverse effects can be increased when Tasimelteon is combined with Paroxetine.
Lanreotide Injection	Lanreotide Injection The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Lanreotide.
Pirfenidone	Pirfenidone The metabolism of Pirfenidone can be decreased when combined with Paroxetine.
Nintedanib	Nintedanib The metabolism of Nintedanib can be decreased when combined with Paroxetine.
Secukinumab Injection	Secukinumab Injection The metabolism of Paroxetine can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection The serum concentration of Risperidone can be increased when it is combined with Paroxetine.
Palbociclib	Palbociclib The metabolism of Palbociclib can be decreased when combined with Paroxetine.
Insulin Human Inhalation	Insulin Human Inhalation The metabolism of Paroxetine can be increased when combined with Insulin human.
Lenvatinib	Lenvatinib The metabolism of Paroxetine can be decreased when combined with Lenvatinib.
Naloxegol	Naloxegol The metabolism of Paroxetine can be decreased when combined with Naloxegol.
Panobinostat	Panobinostat The metabolism of Panobinostat can be decreased when combined with Paroxetine.
Haloperidol Injection	Haloperidol Injection The risk or severity of CNS depression can be increased when Haloperidol is combined with Paroxetine.
Sonidegib	Sonidegib The metabolism of Sonidegib can be decreased when combined with Paroxetine.
Flibanserin	Flibanserin The risk or severity of adverse effects can be increased when Paroxetine is combined with Flibanserin.
Rolapitant	Rolapitant The metabolism of Rolapitant can be decreased when combined with Paroxetine.
Brexpiprazole	Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Paroxetine.
Ziprasidone Injection	Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Paroxetine.
Cariprazine	Cariprazine The metabolism of Cariprazine can be decreased when combined with Paroxetine.
Eluxadoline	Eluxadoline The risk or severity of constipation can be increased when Paroxetine is combined with Eluxadoline.
Insulin Degludec (rDNA Origin) Injection	Insulin Degludec (rDNA Origin) Injection The metabolism of Paroxetine can be increased when combined with Insulin degludec.
Cobimetinib	Cobimetinib The metabolism of Cobimetinib can be decreased when combined with Paroxetine.
Trabectedin Injection	Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Paroxetine.
Osimertinib	Osimertinib The serum concentration of Paroxetine can be decreased when it is combined with Osimertinib.
Alectinib	Alectinib The metabolism of Alectinib can be decreased when combined with Paroxetine.
Ixazomib	Ixazomib The metabolism of Ixazomib can be decreased when combined with Paroxetine.
Rifapentine	Rifapentine The metabolism of Paroxetine can be increased when combined with Rifapentine.
Lesinurad	Lesinurad The metabolism of Lesinurad can be decreased when combined with Paroxetine.
Defibrotide Injection	Defibrotide Injection The risk or severity of hemorrhage can be increased when Paroxetine is combined with Defibrotide.
Brivaracetam Injection	Brivaracetam Injection The risk or severity of adverse effects can be increased when Brivaracetam is combined with Paroxetine.
Venetoclax	Venetoclax The metabolism of Venetoclax can be decreased when combined with Paroxetine.
Cobicistat	Cobicistat The metabolism of Paroxetine can be decreased when combined with Cobicistat.
Midodrine	Midodrine The risk or severity of Tachycardia can be increased when Midodrine is combined with Paroxetine.
Pimavanserin	Pimavanserin The risk or severity of adverse effects can be increased when Paroxetine is combined with Pimavanserin.
Obeticholic Acid	Obeticholic Acid The metabolism of Paroxetine can be decreased when combined with Obeticholic acid.
Diphenhydramine Injection	Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Paroxetine.
Rucaparib	Rucaparib The metabolism of Rucaparib can be decreased when combined with Paroxetine.
Lixisenatide Injection	Lixisenatide Injection The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Lixisenatide.
Ribociclib	Ribociclib The metabolism of Ribociclib can be decreased when combined with Paroxetine.
Parathyroid Hormone Injection	Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Paroxetine.
Brigatinib	Brigatinib The metabolism of Brigatinib can be decreased when combined with Paroxetine.
Doxepin (Insomnia)	Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Paroxetine.
Plecanatide	Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Paroxetine.
Deutetrabenazine	Deutetrabenazine The serum concentration of the active metabolites of Deutetrabenazine can be increased when Deutetrabenazine is used in combination with Paroxetine.
Valbenazine	Valbenazine The metabolism of Valbenazine can be decreased when combined with Paroxetine.
Safinamide	Safinamide Safinamide may increase the serotonergic activities of Paroxetine.
Midostaurin	Midostaurin The metabolism of Paroxetine can be decreased when combined with Midostaurin.
Neratinib	Neratinib The metabolism of Neratinib can be decreased when combined with Paroxetine.
Abaloparatide Injection	Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Paroxetine.
Enasidenib	Enasidenib The metabolism of Enasidenib can be decreased when combined with Paroxetine.
Aprepitant/Fosaprepitant Injection	Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be decreased when combined with Paroxetine.
Copanlisib Injection	Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Paroxetine.
Abemaciclib	Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Paroxetine.
Betrixaban	Betrixaban The risk or severity of hemorrhage can be increased when Paroxetine is combined with Betrixaban.
Acalabrutinib	Acalabrutinib The metabolism of Acalabrutinib can be decreased when combined with Paroxetine.
Letermovir	Letermovir The metabolism of Letermovir can be decreased when combined with Paroxetine.
Semaglutide Injection	Semaglutide Injection The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Semaglutide.
Tetrabenazine	Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Paroxetine.
Ertugliflozin	Ertugliflozin The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Ertugliflozin.
Buprenorphine Injection	Buprenorphine Injection Paroxetine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide	Apalutamide The serum concentration of Paroxetine can be increased when it is combined with Apalutamide.
Baricitinib	Baricitinib The metabolism of Baricitinib can be decreased when combined with Paroxetine.
Lofexidine	Lofexidine The therapeutic efficacy of Paroxetine can be increased when used in combination with Lofexidine.
Eliglustat	Eliglustat The metabolism of Eliglustat can be decreased when combined with Paroxetine.
Encorafenib	Encorafenib The metabolism of Encorafenib can be decreased when combined with Paroxetine.
Binimetinib	Binimetinib The metabolism of Binimetinib can be decreased when combined with Paroxetine.
Ivosidenib	Ivosidenib The metabolism of Ivosidenib can be decreased when combined with Paroxetine.
Elagolix	Elagolix The metabolism of Elagolix can be decreased when combined with Paroxetine.
Tafenoquine	Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Paroxetine.
Cannabidiol	Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Paroxetine.
Dacomitinib	Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Paroxetine.
Duvelisib	Duvelisib The metabolism of Duvelisib can be decreased when combined with Paroxetine.
Stiripentol	Stiripentol The metabolism of Paroxetine can be decreased when combined with Stiripentol.
Gilteritinib	Gilteritinib The therapeutic efficacy of Paroxetine can be decreased when used in combination with Gilteritinib.
Lorlatinib	Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Paroxetine.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Paroxetine.
Rifamycin	Rifamycin The metabolism of Rifamycin can be increased when combined with Paroxetine.
Prucalopride	Prucalopride The metabolism of Prucalopride can be decreased when combined with Paroxetine.
Magnesium Citrate	Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Paroxetine.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Paroxetine can be increased when combined with Emapalumab.
Siponimod	Siponimod The metabolism of Siponimod can be decreased when combined with Paroxetine.
Acyclovir Ophthalmic	Acyclovir Ophthalmic The metabolism of Acyclovir can be decreased when combined with Paroxetine.
Caplacizumab-yhdp Injection	Caplacizumab-yhdp Injection The risk or severity of hemorrhage can be increased when Paroxetine is combined with Caplacizumab.
Erdafitinib	Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Paroxetine.
Esomeprazole Injection	Esomeprazole Injection The metabolism of Paroxetine can be decreased when combined with Esomeprazole.
Alpelisib	Alpelisib The metabolism of Alpelisib can be decreased when combined with Paroxetine.
Brexanolone Injection	Brexanolone Injection The risk or severity of adverse effects can be increased when Brexanolone is combined with Paroxetine.
Solriamfetol	Solriamfetol The risk or severity of Tachycardia can be increased when Solriamfetol is combined with Paroxetine.
Triclabendazole	Triclabendazole The metabolism of Triclabendazole can be decreased when combined with Paroxetine.
Entrectinib	Entrectinib The metabolism of Entrectinib can be decreased when combined with Paroxetine.
Pexidartinib	Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Paroxetine.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Paroxetine.
Pitolisant	Pitolisant The serum concentration of Pitolisant can be increased when it is combined with Paroxetine.
Fedratinib	Fedratinib The metabolism of Fedratinib can be decreased when combined with Paroxetine.
Lefamulin	Lefamulin The metabolism of Lefamulin can be decreased when combined with Paroxetine.
Phenytoin Injection	Phenytoin Injection The serum concentration of Phenytoin can be decreased when it is combined with Paroxetine.
Fosphenytoin Injection	Fosphenytoin Injection The serum concentration of Fosphenytoin can be decreased when it is combined with Paroxetine.
Zanubrutinib	Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Paroxetine.
Voxelotor	Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Paroxetine.
Avapritinib	Avapritinib The metabolism of Avapritinib can be decreased when combined with Paroxetine.
Lumateperone	Lumateperone The risk or severity of adverse effects can be increased when Lumateperone is combined with Paroxetine.
Lasmiditan	Lasmiditan The risk or severity of serotonin syndrome can be increased when Lasmiditan is combined with Paroxetine.
Tazemetostat	Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Paroxetine.
Cenobamate	Cenobamate The serum concentration of Cenobamate can be decreased when it is combined with Paroxetine.
Selumetinib	Selumetinib The metabolism of Selumetinib can be decreased when combined with Paroxetine.
Tucatinib	Tucatinib The metabolism of Tucatinib can be decreased when combined with Paroxetine.
Selpercatinib	Selpercatinib The serum concentration of Selpercatinib can be increased when it is combined with Paroxetine.
Capmatinib	Capmatinib The serum concentration of Capmatinib can be increased when it is combined with Paroxetine.
Lemborexant	Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Paroxetine.
Fenfluramine	Fenfluramine The risk or severity of serotonin syndrome can be increased when Fenfluramine is combined with Paroxetine.
Octreotide	Octreotide The risk or severity of hypoglycemia can be increased when Octreotide is combined with Paroxetine.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Paroxetine can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Paroxetine.
Viloxazine	Viloxazine The risk or severity of adverse effects can be increased when Paroxetine is combined with Viloxazine.
Theophylline	Theophylline The serum concentration of Theophylline can be increased when it is combined with Paroxetine.
Fenoprofen	Fenoprofen The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Fenoprofen.
Indomethacin	Indomethacin The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Indomethacin.
Mefenamic Acid	Mefenamic Acid The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Mefenamic acid.
Naproxen	Naproxen The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Naproxen.
Tolmetin	Tolmetin The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Tolmetin.
Sulindac	Sulindac The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Sulindac.
Trazodone	Trazodone The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Trazodone.
Hydroxyurea	Hydroxyurea The metabolism of Paroxetine can be decreased when combined with Hydroxyurea.
Phenobarbital	Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Paroxetine.
Metaxalone	Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Paroxetine.
Methotrexate Injection	Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Paroxetine.
Levorphanol	Levorphanol The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Paroxetine.
Primidone	Primidone The metabolism of Paroxetine can be increased when combined with Primidone.
Methsuximide	Methsuximide The risk or severity of adverse effects can be increased when Methsuximide is combined with Paroxetine.
Diethylpropion	Diethylpropion The risk or severity of adverse effects can be increased when Paroxetine is combined with Diethylpropion.
Chlorpromazine	Chlorpromazine The metabolism of Paroxetine can be decreased when combined with Chlorpromazine.
Diazepam	Diazepam The risk or severity of adverse effects can be increased when Paroxetine is combined with Diazepam.
Oxazepam	Oxazepam The risk or severity of adverse effects can be increased when Paroxetine is combined with Oxazepam.
Flurazepam	Flurazepam The risk or severity of adverse effects can be increased when Flurazepam is combined with Paroxetine.
Clorazepate	Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Paroxetine.
Lorazepam	Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Paroxetine.
Carmustine	Carmustine The metabolism of Paroxetine can be decreased when combined with Carmustine.
Amantadine	Amantadine The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Amantadine.
Codeine	Codeine The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Codeine.
Meprobamate	Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Paroxetine.
Chlordiazepoxide	Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Paroxetine.
Bromocriptine	Bromocriptine The risk or severity of adverse effects can be increased when Bromocriptine is combined with Paroxetine.
Metaproterenol	Metaproterenol The risk or severity of Tachycardia can be increased when Paroxetine is combined with Orciprenaline.
Tranylcypromine	Tranylcypromine Paroxetine may increase the serotonergic activities of Tranylcypromine.
Phenelzine	Phenelzine Paroxetine may increase the serotonergic activities of Phenelzine.
Procarbazine	Procarbazine Procarbazine may increase the serotonergic activities of Paroxetine.
Ergoloid Mesylates	Ergoloid Mesylates The risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Paroxetine.
Minocycline	Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Paroxetine.
Prochlorperazine	Prochlorperazine The metabolism of Paroxetine can be decreased when combined with Prochlorperazine.
Thioridazine	Thioridazine Paroxetine may increase the QTc-prolonging activities of Thioridazine.
Trifluoperazine	Trifluoperazine The risk or severity of adverse effects can be increased when Paroxetine is combined with Trifluoperazine.
Dapsone	Dapsone The metabolism of Dapsone can be decreased when combined with Paroxetine.
Sulfadiazine	Sulfadiazine The risk or severity of hypoglycemia can be increased when Sulfadiazine is combined with Paroxetine.
Oxycodone	Oxycodone The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Oxycodone.
Methadone	Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Paroxetine.
Oxybutynin	Oxybutynin The metabolism of Paroxetine can be decreased when combined with Oxybutynin.
Benztropine	Benztropine The metabolism of Benzatropine can be decreased when combined with Paroxetine.
Maprotiline	Maprotiline The metabolism of Maprotiline can be decreased when combined with Paroxetine.
Ibuprofen	Ibuprofen The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Ibuprofen.
Trihexyphenidyl	Trihexyphenidyl Paroxetine may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine	Orphenadrine Paroxetine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine	Perphenazine The metabolism of Perphenazine can be decreased when combined with Paroxetine.
Azathioprine	Azathioprine The metabolism of Azathioprine can be decreased when combined with Paroxetine.
Fluphenazine	Fluphenazine The risk or severity of adverse effects can be increased when Fluphenazine is combined with Paroxetine.
Phentermine	Phentermine The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Paroxetine.
Amoxapine	Amoxapine The metabolism of Paroxetine can be decreased when combined with Amoxapine.
Sulfasalazine	Sulfasalazine The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Sulfasalazine.
Doxorubicin	Doxorubicin The metabolism of Paroxetine can be decreased when combined with Doxorubicin.
Mechlorethamine	Mechlorethamine The therapeutic efficacy of Paroxetine can be decreased when used in combination with Mechlorethamine.
Pyridostigmine	Pyridostigmine The therapeutic efficacy of Paroxetine can be decreased when used in combination with Pyridostigmine.
Carbamazepine	Carbamazepine The metabolism of Paroxetine can be decreased when combined with Carbamazepine.
Molindone	Molindone The risk or severity of adverse effects can be increased when Paroxetine is combined with Molindone.
Clonidine	Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Paroxetine.
Cimetidine	Cimetidine The serum concentration of Paroxetine can be increased when it is combined with Cimetidine.
Warfarin	Warfarin The risk or severity of bleeding can be increased when Paroxetine is combined with Warfarin.
Clonazepam	Clonazepam The risk or severity of adverse effects can be increased when Clonazepam is combined with Paroxetine.
Loperamide	Loperamide The metabolism of Loperamide can be decreased when combined with Paroxetine.
Promethazine	Promethazine The metabolism of Promethazine can be decreased when combined with Paroxetine.
Meclofenamate	Meclofenamate The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Meclofenamic acid.
Griseofulvin	Griseofulvin The metabolism of Paroxetine can be increased when combined with Griseofulvin.
Loxapine	Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Paroxetine.
Chloroquine	Chloroquine The metabolism of Chloroquine can be decreased when combined with Paroxetine.
Quinine	Quinine The metabolism of Quinine can be decreased when combined with Paroxetine.
Ethosuximide	Ethosuximide The risk or severity of adverse effects can be increased when Ethosuximide is combined with Paroxetine.
Triamterene	Triamterene The metabolism of Paroxetine can be decreased when combined with Triamterene.
Lactulose	Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Paroxetine.
Sulfinpyrazone	Sulfinpyrazone The risk or severity of hemorrhage can be increased when Paroxetine is combined with Sulfinpyrazone.
Chlorothiazide	Chlorothiazide The risk or severity of hyponatremia can be increased when Paroxetine is combined with Chlorothiazide.
Chlorthalidone	Chlorthalidone The risk or severity of hyponatremia can be increased when Paroxetine is combined with Chlorthalidone.
Metolazone	Metolazone The risk or severity of hyponatremia can be increased when Paroxetine is combined with Metolazone.
Clindamycin Injection	Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Paroxetine.
Secobarbital	Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Paroxetine.
Desipramine	Desipramine The metabolism of Desipramine can be decreased when combined with Paroxetine.
Amitriptyline	Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Paroxetine.
Imipramine	Imipramine The metabolism of Paroxetine can be decreased when combined with Imipramine.
Probenecid	Probenecid The metabolism of Paroxetine can be decreased when combined with Probenecid.
Quinidine	Quinidine The metabolism of Quinidine can be decreased when combined with Paroxetine.
Procainamide	Procainamide The metabolism of Procainamide can be decreased when combined with Paroxetine.
Isoniazid	Isoniazid The metabolism of Paroxetine can be decreased when combined with Isoniazid.
Rifampin	Rifampin The metabolism of Paroxetine can be increased when combined with Rifampicin.
Disopyramide	Disopyramide Paroxetine may increase the central nervous system depressant (CNS depressant) activities of Disopyramide.
Valproic Acid	Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Paroxetine.
Tamoxifen	Tamoxifen The therapeutic efficacy of Tamoxifen can be decreased when used in combination with Paroxetine.
Butabarbital	Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Paroxetine.
Levothyroxine	Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Paroxetine.
Liothyronine	Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Paroxetine.
Methimazole	Methimazole The metabolism of Paroxetine can be decreased when combined with Methimazole.
Propylthiouracil	Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Paroxetine.
Chlorpropamide	Chlorpropamide The metabolism of Chlorpropamide can be decreased when combined with Paroxetine.
Glucagon Injection	Glucagon Injection Paroxetine may increase the gastrointestinal motility reducing activities of Glucagon.
Tolbutamide	Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Paroxetine.
Tolazamide	Tolazamide The metabolism of Tolazamide can be decreased when combined with Paroxetine.
Dextromethorphan	Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Paroxetine.
Cyclobenzaprine	Cyclobenzaprine The risk or severity of CNS depression can be increased when Paroxetine is combined with Cyclobenzaprine.
Niacin	Niacin The metabolism of Paroxetine can be decreased when combined with Niacin.
Baclofen	Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Paroxetine.
Doxylamine	Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Paroxetine.
Cyproheptadine	Cyproheptadine The therapeutic efficacy of Paroxetine can be decreased when used in combination with Cyproheptadine.
Clemastine	Clemastine The risk or severity of adverse effects can be increased when Paroxetine is combined with Clemastine.
Chlorpheniramine	Chlorpheniramine The metabolism of Chlorpheniramine can be decreased when combined with Paroxetine.
Brompheniramine	Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Paroxetine.
Meclizine	Meclizine The metabolism of Meclizine can be decreased when combined with Paroxetine.
Methyclothiazide	Methyclothiazide The risk or severity of hyponatremia can be increased when Paroxetine is combined with Methyclothiazide.
Hydrochlorothiazide	Hydrochlorothiazide The risk or severity of hyponatremia can be increased when Paroxetine is combined with Hydrochlorothiazide.
Dantrolene	Dantrolene The risk or severity of adverse effects can be increased when Dantrolene is combined with Paroxetine.
Chlorzoxazone	Chlorzoxazone The metabolism of Chlorzoxazone can be decreased when combined with Paroxetine.
Carisoprodol	Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Paroxetine.
Methocarbamol	Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Paroxetine.
Pseudoephedrine	Pseudoephedrine The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Pseudoephedrine.
Nortriptyline	Nortriptyline The metabolism of Paroxetine can be decreased when combined with Nortriptyline.
Nadolol	Nadolol The metabolism of Nadolol can be decreased when combined with Paroxetine.
Butorphanol Injection	Butorphanol Injection The risk or severity of serotonin syndrome can be increased when Butorphanol is combined with Paroxetine.
Nalbuphine Injection	Nalbuphine Injection The risk or severity of serotonin syndrome can be increased when Nalbuphine is combined with Paroxetine.
Trimethobenzamide	Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Paroxetine.
Flavoxate	Flavoxate Paroxetine may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Fluorouracil Injection	Fluorouracil Injection The metabolism of Paroxetine can be decreased when combined with Fluorouracil.
Colchicine	Colchicine The metabolism of Colchicine can be decreased when combined with Paroxetine.
Cephalexin	Cephalexin The metabolism of Cephalexin can be decreased when combined with Paroxetine.
Dacarbazine	Dacarbazine The metabolism of Dacarbazine can be decreased when combined with Paroxetine.
Acetazolamide	Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Paroxetine.
Calcitonin Salmon Injection	Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Paroxetine.
Ketoconazole	Ketoconazole The metabolism of Paroxetine can be decreased when combined with Ketoconazole.
Pyrantel	Pyrantel The risk or severity of adverse effects can be increased when Pyrantel is combined with Paroxetine.
Thiotepa Injection	Thiotepa Injection The metabolism of Paroxetine can be decreased when combined with Thiotepa.
Vincristine Injection	Vincristine Injection The metabolism of Vincristine can be decreased when combined with Paroxetine.
Dipyridamole	Dipyridamole The risk or severity of hemorrhage can be increased when Paroxetine is combined with Dipyridamole.
Isoxsuprine	Isoxsuprine The risk or severity of Tachycardia can be increased when Paroxetine is combined with Isoxsuprine.
Vinblastine	Vinblastine The metabolism of Paroxetine can be decreased when combined with Vinblastine.
Metoprolol	Metoprolol The metabolism of Metoprolol can be decreased when combined with Paroxetine.
Hydroxyzine	Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Paroxetine.
Thiothixene	Thiothixene The risk or severity of adverse effects can be increased when Paroxetine is combined with Thiothixene.
Aspirin	Aspirin The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Acetylsalicylic acid.
Salsalate	Salsalate The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Salsalate.
Alprazolam	Alprazolam The metabolism of Alprazolam can be decreased when combined with Paroxetine.
Temazepam	Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Paroxetine.
Triazolam	Triazolam The risk or severity of adverse effects can be increased when Triazolam is combined with Paroxetine.
Dicyclomine	Dicyclomine Paroxetine may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine	Hyoscyamine Paroxetine may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline	Propantheline Paroxetine may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Trimethoprim	Trimethoprim The metabolism of Trimethoprim can be decreased when combined with Paroxetine.
Diltiazem	Diltiazem The metabolism of Diltiazem can be decreased when combined with Paroxetine.
Nifedipine	Nifedipine The metabolism of Nifedipine can be decreased when combined with Paroxetine.
Timolol	Timolol The metabolism of Timolol can be decreased when combined with Paroxetine.
Verapamil	Verapamil The metabolism of Verapamil can be decreased when combined with Paroxetine.
Atenolol	Atenolol The metabolism of Atenolol can be decreased when combined with Paroxetine.
Pindolol	Pindolol The metabolism of Pindolol can be decreased when combined with Paroxetine.
Cisplatin Injection	Cisplatin Injection The therapeutic efficacy of Paroxetine can be decreased when used in combination with Cisplatin.
Diflunisal	Diflunisal The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Diflunisal.
Piroxicam	Piroxicam The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Piroxicam.
Streptozocin	Streptozocin The metabolism of Paroxetine can be increased when combined with Streptozocin.
Etoposide	Etoposide The metabolism of Etoposide can be decreased when combined with Paroxetine.
Glyburide	Glyburide The metabolism of Glyburide can be decreased when combined with Paroxetine.
Glipizide	Glipizide The metabolism of Glipizide can be decreased when combined with Paroxetine.
Indapamide	Indapamide The risk or severity of hyponatremia can be increased when Paroxetine is combined with Indapamide.
Nafcillin Injection	Nafcillin Injection The metabolism of Paroxetine can be increased when combined with Nafcillin.
Pentoxifylline	Pentoxifylline The risk or severity of hemorrhage can be increased when Paroxetine is combined with Pentoxifylline.
Pentamidine Injection	Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Paroxetine.
Labetalol	Labetalol The metabolism of Labetalol can be decreased when combined with Paroxetine.
Gemfibrozil	Gemfibrozil The metabolism of Gemfibrozil can be decreased when combined with Paroxetine.
Guanabenz	Guanabenz The metabolism of Paroxetine can be decreased when combined with Guanabenz.
Ketoprofen	Ketoprofen The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Ketoprofen.
Pimozide	Pimozide The risk or severity of QTc prolongation can be increased when Paroxetine is combined with Pimozide.
Flurbiprofen	Flurbiprofen The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Flurbiprofen.
Amiodarone	Amiodarone The metabolism of Amiodarone can be decreased when combined with Paroxetine.
Buspirone	Buspirone The metabolism of Buspirone can be decreased when combined with Paroxetine.
Lovastatin	Lovastatin The metabolism of Lovastatin can be decreased when combined with Paroxetine.
Ciprofloxacin	Ciprofloxacin The metabolism of Paroxetine can be decreased when combined with Ciprofloxacin.
Mesalamine	Mesalamine The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Mesalazine.
Diclofenac	Diclofenac The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Diclofenac.
Fluoxetine	Fluoxetine The serum concentration of Paroxetine can be increased when it is combined with Fluoxetine.
Interferon Alfa-2b Injection	Interferon Alfa-2b Injection The metabolism of Paroxetine can be decreased when combined with Interferon alfa-2b.
Clozapine	Clozapine The metabolism of Paroxetine can be decreased when combined with Clozapine.
Estazolam	Estazolam The risk or severity of adverse effects can be increased when Paroxetine is combined with Estazolam.
Idarubicin	Idarubicin The metabolism of Idarubicin can be decreased when combined with Paroxetine.
Ofloxacin	Ofloxacin The metabolism of Paroxetine can be decreased when combined with Ofloxacin.
Etodolac	Etodolac The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Etodolac.
Felodipine	Felodipine The metabolism of Paroxetine can be decreased when combined with Felodipine.
Nabumetone	Nabumetone The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Nabumetone.
Pravastatin	Pravastatin The risk or severity of increased glucose can be increased when Pravastatin is combined with Paroxetine.
Simvastatin	Simvastatin The metabolism of Simvastatin can be decreased when combined with Paroxetine.
Teniposide Injection	Teniposide Injection The metabolism of Teniposide can be decreased when combined with Paroxetine.
Oxaprozin	Oxaprozin The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Oxaprozin.
Rifabutin	Rifabutin The metabolism of Paroxetine can be increased when combined with Rifabutin.
Sotalol	Sotalol The metabolism of Sotalol can be decreased when combined with Paroxetine.
Bisoprolol	Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Paroxetine.
Zolpidem	Zolpidem Paroxetine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin	Doxazosin The metabolism of Doxazosin can be decreased when combined with Paroxetine.
Omeprazole	Omeprazole The metabolism of Omeprazole can be decreased when combined with Paroxetine.
Cisapride	Cisapride The metabolism of Paroxetine can be decreased when combined with Cisapride.
Gabapentin	Gabapentin The risk or severity of adverse effects can be increased when Paroxetine is combined with Gabapentin.
Fluvastatin	Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Paroxetine.
Venlafaxine	Venlafaxine The metabolism of Paroxetine can be decreased when combined with Venlafaxine.
Nizatidine	Nizatidine The therapeutic efficacy of Paroxetine can be decreased when used in combination with Nizatidine.
Famciclovir	Famciclovir The metabolism of Famciclovir can be decreased when combined with Paroxetine.
Fluvoxamine	Fluvoxamine The metabolism of Paroxetine can be decreased when combined with Fluvoxamine.
Nefazodone	Nefazodone The metabolism of Nefazodone can be decreased when combined with Paroxetine.
Lamotrigine	Lamotrigine The risk or severity of adverse effects can be increased when Lamotrigine is combined with Paroxetine.
Losartan	Losartan The metabolism of Losartan can be decreased when combined with Paroxetine.
Tramadol	Tramadol The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Tramadol.
Vinorelbine Injection	Vinorelbine Injection The metabolism of Paroxetine can be decreased when combined with Vinorelbine.
Lansoprazole	Lansoprazole The metabolism of Lansoprazole can be decreased when combined with Paroxetine.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Paroxetine.
Nicardipine	Nicardipine The metabolism of Paroxetine can be decreased when combined with Nicardipine.
Bupropion	Bupropion The risk or severity of adverse effects can be increased when Bupropion is combined with Paroxetine.
Ticlopidine	Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Paroxetine.
Saquinavir	Saquinavir The metabolism of Paroxetine can be decreased when combined with Saquinavir.
Metformin	Metformin The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Metformin.
Dalteparin Injection	Dalteparin Injection The risk or severity of hemorrhage can be increased when Paroxetine is combined with Dalteparin.
Riluzole	Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Paroxetine.
Acarbose	Acarbose The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Acarbose.
Glimepiride	Glimepiride The metabolism of Glimepiride can be decreased when combined with Paroxetine.
Ritonavir	Ritonavir The serum concentration of Paroxetine can be increased when it is combined with Ritonavir.
Docetaxel Injection	Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Paroxetine.
Clomipramine	Clomipramine The metabolism of Paroxetine can be decreased when combined with Clomipramine.
Zafirlukast	Zafirlukast The metabolism of Paroxetine can be decreased when combined with Zafirlukast.
Mirtazapine	Mirtazapine Paroxetine may increase the serotonergic activities of Mirtazapine.
Topiramate	Topiramate The risk or severity of hyperthermia and oligohydrosis can be increased when Paroxetine is combined with Topiramate.
Zileuton	Zileuton The metabolism of Zileuton can be decreased when combined with Paroxetine.
Valsartan	Valsartan The metabolism of Paroxetine can be decreased when combined with Valsartan.
Insulin Lispro Injection	Insulin Lispro Injection The metabolism of Paroxetine can be increased when combined with Insulin lispro.
Pramipexole	Pramipexole Paroxetine may increase the sedative activities of Pramipexole.
Donepezil	Donepezil The therapeutic efficacy of Paroxetine can be decreased when used in combination with Donepezil.
Nelfinavir	Nelfinavir The metabolism of Nelfinavir can be decreased when combined with Paroxetine.
Azithromycin	Azithromycin The metabolism of Azithromycin can be decreased when combined with Paroxetine.
Loratadine	Loratadine Paroxetine may increase the anticholinergic activities of Loratadine.
Carvedilol	Carvedilol The metabolism of Carvedilol can be decreased when combined with Paroxetine.
Nilutamide	Nilutamide The metabolism of Paroxetine can be decreased when combined with Nilutamide.
Flutamide	Flutamide The metabolism of Paroxetine can be decreased when combined with Flutamide.
Selegiline	Selegiline Paroxetine may increase the serotonergic activities of Selegiline.
Bicalutamide	Bicalutamide The metabolism of Paroxetine can be decreased when combined with Bicalutamide.
Sertraline	Sertraline The metabolism of Sertraline can be decreased when combined with Paroxetine.
Propafenone	Propafenone The metabolism of Propafenone can be decreased when combined with Paroxetine.
Letrozole	Letrozole The metabolism of Paroxetine can be decreased when combined with Letrozole.
Irbesartan	Irbesartan The metabolism of Irbesartan can be decreased when combined with Paroxetine.
Tamsulosin	Tamsulosin The metabolism of Tamsulosin can be decreased when combined with Paroxetine.
Ropinirole	Ropinirole Paroxetine may increase the sedative activities of Ropinirole.
Quetiapine	Quetiapine The metabolism of Quetiapine can be decreased when combined with Paroxetine.
Cetirizine	Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Paroxetine.
Tolcapone	Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Paroxetine.
Citalopram	Citalopram Citalopram may increase the QTc-prolonging activities of Paroxetine.
Capecitabine	Capecitabine The metabolism of Capecitabine can be decreased when combined with Paroxetine.
Efavirenz	Efavirenz The risk or severity of adverse effects can be increased when Efavirenz is combined with Paroxetine.
Sildenafil	Sildenafil The metabolism of Sildenafil can be decreased when combined with Paroxetine.
Pioglitazone	Pioglitazone The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Pioglitazone.
Celecoxib	Celecoxib The risk or severity of bleeding can be increased when Celecoxib is combined with Paroxetine.
Rosiglitazone	Rosiglitazone The metabolism of Paroxetine can be decreased when combined with Rosiglitazone.
Tolterodine	Tolterodine The metabolism of Tolterodine can be decreased when combined with Paroxetine.
Thalidomide	Thalidomide Paroxetine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Balsalazide	Balsalazide The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Balsalazide.
Nateglinide	Nateglinide The metabolism of Nateglinide can be decreased when combined with Paroxetine.
Galantamine	Galantamine The metabolism of Paroxetine can be decreased when combined with Galantamine.
Levetiracetam	Levetiracetam The risk or severity of adverse effects can be increased when Levetiracetam is combined with Paroxetine.
Rabeprazole	Rabeprazole The metabolism of Rabeprazole can be decreased when combined with Paroxetine.
Terbinafine	Terbinafine The metabolism of Paroxetine can be decreased when combined with Terbinafine.