Metformin

Generic name: Pronounced as (met for' min)
Brand names
  • Fortamet®
  • Glucophage®
  • Glumetza®
  • Riomet®
  • Trijardy® (as a combination product containing Empagliflozin, Linagliptin, Metformin)
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 03/15/2020

Metformin may rarely cause a serious, life-threatening condition called lactic acidosis. Tell your doctor if you have kidney disease. Your doctor will probably tell you not to take metformin. Also, tell your doctor if you are over 65 years old and if you have ever had a heart attack; stroke; diabetic ketoacidosis (blood sugar that is high enough to cause severe symptoms and requires emergency medical treatment); a coma; or heart or liver disease. Taking certain other medications with metformin may increase the risk of lactic acidosis. Tell your doctor if you are taking acetazolamide (Diamox), dichlorphenamide (Keveyis), methazolamide, topiramate (Topamax, in Qsymia), or zonisamide (Zonegran).

Tell your doctor if you have recently had any of the following conditions, or if you develop them during treatment: serious infection; severe diarrhea, vomiting, or fever; or if you drink much less fluid than usual for any reason. You may have to stop taking metformin until you recover.

If you are having surgery, including dental surgery, or any major medical procedure, tell the doctor that you are taking metformin. Also, tell your doctor if you plan to have any x-ray procedure in which dye is injected, especially if you drink or have ever drunk large amounts of alcohol or have or have had liver disease or heart failure. You may need to stop taking metformin before the procedure and wait 48 hours to restart treatment. Your doctor will tell you exactly when you should stop taking metformin and when you should start taking it again.

If you experience any of the following symptoms, stop taking metformin and call your doctor immediately: extreme tiredness, weakness, or discomfort; nausea; vomiting; stomach pain; decreased appetite; deep and rapid breathing or shortness of breath; dizziness; lightheadedness; fast or slow heartbeat; flushing of the skin; muscle pain; or feeling cold, especially in your hands or feet.

Tell your doctor if you regularly drink alcohol or sometimes drink large amounts of alcohol in a short time (binge drinking). Drinking alcohol increases your risk of developing lactic acidosis or may cause a decrease in blood sugar. Ask your doctor how much alcohol is safe to drink while you are taking metformin.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before and during treatment to check how well your kidneys are working and your body's response to metformin. Talk to your doctor about the risk(s) of taking metformin.

Metformin is used alone or with other medications, including insulin, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Metformin is in a class of drugs called biguanides. Metformin helps to control the amount of glucose (sugar) in your blood. It decreases the amount of glucose you absorb from your food and the amount of glucose made by your liver. Metformin also increases your body's response to insulin, a natural substance that controls the amount of glucose in the blood. Metformin is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood).

Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

Metformin comes as a liquid, a tablet, and an extended-release (long-acting) tablet to take by mouth. The liquid is usually taken with meals one or two times a day. The regular tablet is usually taken with meals two or three times a day. The extended-release tablet is usually taken once daily with the evening meal. To help you remember to take metformin, take it around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take metformin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow metformin extended-release tablets whole; do not split, chew, or crush them.

Your doctor may start you on a low dose of metformin and gradually increase your dose not more often than once every 1–2 weeks. You will need to monitor your blood sugar carefully so your doctor will be able to tell how well metformin is working.

Metformin controls diabetes but does not cure it. Continue to take metformin even if you feel well. Do not stop taking metformin without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking metformin,

  • tell your doctor and pharmacist if you are allergic to metformin, any of the ingredients of metformin liquid or tablets, or any other medications. Ask your pharmacist or check the manufacturer's patient information for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: amiloride (Midamor); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); beta-blockers such as atenolol (Tenormin), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal, InnoPran); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Diltzac, others), felodipine, isradipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab CR, Procardia), nimodipine (Nymalize), nisoldipine (Sular), and verapamil (Calan, Covera, Verelan, in Tarka); cimetidine (Tagamet); digoxin (Lanoxin); diuretics ('water pills'); furosemide (Lasix); hormone replacement therapy; insulin or other medications for diabetes; isoniazid (Laniazid, in Rifamate, in Rifater); medications for asthma and colds; medications for mental illness and nausea; medications for thyroid disease; morphine (MS Contin, others); niacin; oral contraceptives ('birth control pills'); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); phenytoin (Dilantin, Phenytek); procainamide; quinidine (in Nuedexta); quinine; ranitidine (Zantac); triamterene (Dyrenium, in Maxzide, others); trimethoprim (Primsol); or vancomycin (Vancocin). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had any medical condition, especially those mentioned in the IMPORTANT WARNING section.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking metformin, call your doctor.

  • tell your doctor if you eat less or exercise more than usual. This can affect your blood sugar. Your doctor will give you instructions if this happens.

Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. It is important to eat a healthful diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

This medication may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms.

  • Metformin may cause side effects. Tell your doctor if any of these symptoms are severe, do not go away, go away and come back, or do not begin for some time after you begin taking metformin:

    • diarrhea

    • bloating

    • stomach pain

    • gas

    • indigestion

    • constipation

    • unpleasant metallic taste in mouth

    • heartburn

    • headache

    • flushing of the skin

    • nail changes

    • muscle pain

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency treatment:

    • chest pain

    • rash

  • Metformin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat, and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include hypoglycemia symptoms as well as the following:

  • extreme tiredness

  • weakness

  • discomfort

  • vomiting

  • nausea

  • stomach pain

  • decreased appetite

  • deep, rapid breathing

  • shortness of breath

  • dizziness

  • lightheadedness

  • abnormally fast or slow heartbeat

  • flushing of the skin

  • muscle pain

  • feeling cold

Your doctor will tell you how to check your response to this medication by measuring your blood sugar levels at home. Follow these instructions carefully.

If you are taking the extended-release tablets, you may notice something that looks like a tablet in your stool. This is just the empty tablet shell, and this does not mean that you did not get your complete dose of medication.

You should always wear a diabetic identification bracelet to be sure you get proper treatment in an emergency.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Actoplus Met® (containing Metformin, Pioglitazone)
  • Avandamet® (containing Metformin, Rosiglitazone)
  • Invokamet® (containing Canagliflozin, Metformin)
  • Janumet® (containing Metformin, Sitagliptin)
  • Jentadueto® (containing Linagliptin, Metformin)
  • Kazano® (containing Alogliptin, Metformin)
  • Kombiglyze® XR (containing Metformin, Saxagliptin)
  • Metaglip® (containing Glipizide, Metformin)
  • Prandimet® (containing Metformin, Repaglinide)
  • Qternmet® XR (containing Dapagliflozin, Metformin, Saxagliptin), Segluromet® (containing Ertugliflozin, Metformin)
  • Synjardy® (containing Empagliflozin, Metformin)
  • Xigduo® XR (containing Dapagliflozin, Metformin)

Drug Interaction
Moxifloxacin Moxifloxacin The therapeutic efficacy of Metformin can be increased when used in combination with Moxifloxacin.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The risk or severity of adverse effects can be increased when Insulin glargine is combined with Metformin.
Nevirapine Nevirapine The risk or severity of adverse effects can be increased when Nevirapine is combined with Metformin.
Atorvastatin Atorvastatin Metformin may increase the hypolipidaemic activities of Atorvastatin.
Cilostazol Cilostazol Metformin may decrease the excretion rate of Cilostazol which could result in a higher serum level.
Clopidogrel Clopidogrel The serum concentration of Metformin can be increased when it is combined with Clopidogrel.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Metformin which could result in a higher serum level.
Fenofibrate Fenofibrate Metformin may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Guanfacine Guanfacine The risk or severity of adverse effects can be increased when Metformin is combined with Guanfacine.
Magnesium Hydroxide Magnesium Hydroxide Metformin may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Miglitol Miglitol The risk or severity of hypoglycemia can be increased when Metformin is combined with Miglitol.
Mycophenolate Mycophenolate Metformin may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Olsalazine Olsalazine Olsalazine may increase the hypoglycemic activities of Metformin.
Penbutolol Penbutolol The therapeutic efficacy of Metformin can be increased when used in combination with Acebutolol.
Potassium Potassium Potassium may increase the excretion rate of Metformin which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone The therapeutic efficacy of Metformin can be decreased when used in combination with Prednisone.
Ranitidine Ranitidine The serum concentration of Ranitidine can be increased when it is combined with Metformin.
Reserpine Reserpine The serum concentration of Reserpine can be increased when it is combined with Metformin.
Rizatriptan Rizatriptan Metformin may decrease the excretion rate of Rizatriptan which could result in a higher serum level.
Sumatriptan Sumatriptan The therapeutic efficacy of Metformin can be increased when used in combination with Sumatriptan.
Tacrolimus Tacrolimus The therapeutic efficacy of Metformin can be decreased when used in combination with Tacrolimus.
Triamcinolone Triamcinolone The therapeutic efficacy of Metformin can be decreased when used in combination with Triamcinolone.
Ampicillin Injection Ampicillin Injection Metformin may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Metformin which could result in a higher serum level.
Famotidine Injection Famotidine Injection The serum concentration of Metformin can be increased when it is combined with Famotidine.
Fluconazole Injection Fluconazole Injection The risk or severity of hypoglycemia can be increased when Metformin is combined with Fluconazole.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Metformin which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection Hydromorphone may decrease the excretion rate of Metformin which could result in a higher serum level.
Levofloxacin Injection Levofloxacin Injection The excretion of Levofloxacin can be decreased when combined with Metformin.
Meperidine Injection Meperidine Injection Metformin may decrease the excretion rate of Meperidine which could result in a higher serum level.
Methylprednisolone Injection Methylprednisolone Injection The therapeutic efficacy of Metformin can be decreased when used in combination with Methylprednisolone.
Metoclopramide Injection Metoclopramide Injection Metformin may decrease the excretion rate of Metoclopramide which could result in a higher serum level.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Metformin which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Metformin may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Altretamine Altretamine Amphetamine may decrease the excretion rate of Metformin which could result in a higher serum level.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Metformin which could result in a higher serum level.
Cyclosporine Cyclosporine Cyclosporine may decrease the excretion rate of Metformin which could result in a higher serum level.
Torsemide Torsemide The therapeutic efficacy of Metformin can be decreased when used in combination with Torasemide.
Olanzapine Olanzapine The therapeutic efficacy of Metformin can be decreased when used in combination with Olanzapine.
Dofetilide Dofetilide The serum concentration of Dofetilide can be increased when it is combined with Metformin.
Hydroxychloroquine Hydroxychloroquine The therapeutic efficacy of Metformin can be increased when used in combination with Hydroxychloroquine.
Meloxicam Meloxicam Meloxicam may decrease the excretion rate of Metformin which could result in a higher serum level.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Metformin which could result in a higher serum level.
Temozolomide Temozolomide Metformin may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon Zaleplon Metformin may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Linezolid Linezolid Linezolid may increase the hypoglycemic activities of Metformin.
Trimipramine Trimipramine Trimipramine may decrease the hypoglycemic activities of Metformin.
Glycopyrrolate Glycopyrrolate The serum concentration of Metformin can be increased when it is combined with Glycopyrronium.
Perindopril Perindopril The risk or severity of lactic acidosis can be increased when Perindopril is combined with Metformin.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Metformin which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Metformin which could result in a higher serum level.
Sirolimus Sirolimus The therapeutic efficacy of Metformin can be decreased when used in combination with Sirolimus.
Epinephrine Injection Epinephrine Injection The therapeutic efficacy of Metformin can be decreased when used in combination with Epinephrine.
Eplerenone Eplerenone Eplerenone may increase the excretion rate of Metformin which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram Escitalopram The risk or severity of hypoglycemia can be increased when Escitalopram is combined with Metformin.
Zonisamide Zonisamide The risk or severity of lactic acidosis can be increased when Zonisamide is combined with Metformin.
Aripiprazole Aripiprazole The therapeutic efficacy of Metformin can be decreased when used in combination with Aripiprazole.
Atomoxetine Atomoxetine Atomoxetine may decrease the excretion rate of Metformin which could result in a higher serum level.
Atazanavir Atazanavir The therapeutic efficacy of Metformin can be decreased when used in combination with Atazanavir.
Almotriptan Almotriptan Metformin may decrease the excretion rate of Almotriptan which could result in a higher serum level.
Rosuvastatin Rosuvastatin Metformin may increase the hypolipidaemic activities of Rosuvastatin.
Emtricitabine Emtricitabine The excretion of Emtricitabine can be decreased when combined with Metformin.
Memantine Memantine The serum concentration of Memantine can be increased when it is combined with Metformin.
Tadalafil Tadalafil Metformin may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Fosamprenavir Fosamprenavir The therapeutic efficacy of Metformin can be decreased when used in combination with Fosamprenavir.
Gemifloxacin Gemifloxacin The therapeutic efficacy of Metformin can be increased when used in combination with Gemifloxacin.
Progesterone Progesterone The therapeutic efficacy of Metformin can be decreased when used in combination with Progesterone.
Oxandrolone Oxandrolone Oxandrolone may increase the hypoglycemic activities of Metformin.
Protriptyline Protriptyline Protriptyline may decrease the hypoglycemic activities of Metformin.
Duloxetine Duloxetine The risk or severity of hypoglycemia can be increased when Metformin is combined with Duloxetine.
Norethindrone Norethindrone The therapeutic efficacy of Metformin can be decreased when used in combination with Norethisterone.
Tinidazole Tinidazole Metformin may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Trospium Trospium The serum concentration of Trospium can be decreased when it is combined with Metformin.
Bosentan Bosentan The therapeutic efficacy of Metformin can be increased when used in combination with Bosentan.
Cefditoren Cefditoren Metformin may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Metformin which could result in a higher serum level.
Eszopiclone Eszopiclone Metformin may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Ganciclovir Ganciclovir The excretion of Ganciclovir can be decreased when combined with Metformin.
Insulin Aspart (rDNA Origin) Injection Insulin Aspart (rDNA Origin) Injection The risk or severity of adverse effects can be increased when Insulin aspart is combined with Metformin.
Ribavirin Ribavirin Metformin may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Valganciclovir Valganciclovir Metformin may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Adefovir Adefovir Adefovir may decrease the excretion rate of Metformin which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Amphetamine may decrease the excretion rate of Metformin which could result in a higher serum level.
Pramlintide Injection Pramlintide Injection The risk or severity of hypoglycemia can be increased when Metformin is combined with Pramlintide.
Exenatide Injection Exenatide Injection The risk or severity of hypoglycemia can be increased when Metformin is combined with Exenatide.
Isocarboxazid Isocarboxazid Isocarboxazid may increase the hypoglycemic activities of Metformin.
Ramelteon Ramelteon Metformin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Fentanyl Fentanyl Metformin may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Pregabalin Pregabalin The risk or severity of hypoglycemia can be increased when Pregabalin is combined with Metformin.
Tipranavir Tipranavir The therapeutic efficacy of Metformin can be decreased when used in combination with Tipranavir.
Insulin Detemir (rDNA Origin) Injection Insulin Detemir (rDNA Origin) Injection The risk or severity of adverse effects can be increased when Insulin detemir is combined with Metformin.
Ranolazine Ranolazine The serum concentration of Metformin can be increased when it is combined with Ranolazine.
Rasagiline Rasagiline Metformin may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Imatinib Imatinib The serum concentration of Metformin can be increased when it is combined with Imatinib.
Varenicline Varenicline The excretion of Varenicline can be decreased when combined with Metformin.
Albuterol Albuterol Metformin may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone Paliperidone The therapeutic efficacy of Metformin can be decreased when used in combination with Paliperidone.
Clofarabine Injection Clofarabine Injection The serum concentration of Clofarabine can be increased when it is combined with Metformin.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The risk or severity of adverse effects can be increased when Insulin glulisine is combined with Metformin.
Lubiprostone Lubiprostone Metformin may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Oxaliplatin Injection Oxaliplatin Injection The serum concentration of Oxaliplatin can be increased when it is combined with Metformin.
Bismuth Subsalicylate Bismuth Subsalicylate Bismuth subsalicylate may increase the hypoglycemic activities of Metformin.
Darunavir Darunavir The therapeutic efficacy of Metformin can be decreased when used in combination with Darunavir.
Pemetrexed Injection Pemetrexed Injection Metformin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Vorinostat Vorinostat The therapeutic efficacy of Metformin can be decreased when used in combination with Vorinostat.
Sorafenib Sorafenib Metformin may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Sunitinib Sunitinib The risk or severity of hypoglycemia can be increased when Metformin is combined with Sunitinib.
Levocetirizine Levocetirizine Metformin may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Metformin may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Azacitidine Injection Azacitidine Injection Metformin may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Temsirolimus Temsirolimus The therapeutic efficacy of Metformin can be decreased when used in combination with Temsirolimus.
Lenalidomide Lenalidomide Metformin may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Nilotinib Nilotinib The therapeutic efficacy of Metformin can be decreased when used in combination with Nilotinib.
Budesonide Budesonide The risk or severity of hyperglycemia can be increased when Metformin is combined with Budesonide.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Metformin which could result in a higher serum level.
Doripenem Injection Doripenem Injection Metformin may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection Arsenic Trioxide Injection The therapeutic efficacy of Metformin can be decreased when used in combination with Arsenic trioxide.
Desvenlafaxine Desvenlafaxine The risk or severity of hypoglycemia can be increased when Metformin is combined with Desvenlafaxine.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Metformin which could result in a higher serum level.
Nebivolol Nebivolol The therapeutic efficacy of Metformin can be increased when used in combination with Nebivolol.
Flecainide Flecainide The excretion of Flecainide can be decreased when combined with Metformin.
Certolizumab Injection Certolizumab Injection Metformin may decrease the excretion rate of Certolizumab pegol which could result in a higher serum level.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Metformin which could result in a higher serum level.
Methylnaltrexone Injection Methylnaltrexone Injection Metformin may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Midazolam Midazolam Metformin may decrease the excretion rate of Midazolam which could result in a higher serum level.
Dexrazoxane Injection Dexrazoxane Injection Metformin may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
Milnacipran Milnacipran The risk or severity of hypoglycemia can be increased when Metformin is combined with Milnacipran.
Plerixafor Injection Plerixafor Injection Metformin may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine Fesoterodine Metformin may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Betaxolol Betaxolol The therapeutic efficacy of Metformin can be increased when used in combination with Betaxolol.
Iloperidone Iloperidone The therapeutic efficacy of Metformin can be decreased when used in combination with Iloperidone.
Prasugrel Prasugrel Metformin may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Everolimus Everolimus The therapeutic efficacy of Metformin can be decreased when used in combination with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Metformin which could result in a lower serum level and potentially a reduction in efficacy.
Dronedarone Dronedarone The serum concentration of Metformin can be increased when it is combined with Dronedarone.
Pralatrexate Injection Pralatrexate Injection Metformin may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection Metformin may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Telavancin Injection Telavancin Injection Metformin may decrease the excretion rate of Telavancin which could result in a higher serum level.
Topotecan Topotecan The excretion of Topotecan can be decreased when combined with Metformin.
Asenapine Asenapine The therapeutic efficacy of Metformin can be decreased when used in combination with Asenapine.
Pitavastatin Pitavastatin Metformin may increase the hypolipidaemic activities of Pitavastatin.
Levonorgestrel Levonorgestrel The therapeutic efficacy of Metformin can be decreased when used in combination with Levonorgestrel.
Liraglutide Injection Liraglutide Injection The risk or severity of hypoglycemia can be increased when Metformin is combined with Liraglutide.
Dalfampridine Dalfampridine The serum concentration of Dalfampridine can be increased when it is combined with Metformin.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Metformin which could result in a higher serum level.
Lurasidone Lurasidone The therapeutic efficacy of Metformin can be decreased when used in combination with Lurasidone.
Ipilimumab Injection Ipilimumab Injection Metformin may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Metformin which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Metformin may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Roflumilast Roflumilast Metformin may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Triptorelin Injection Triptorelin Injection The therapeutic efficacy of Metformin can be decreased when used in combination with Triptorelin.
Rivaroxaban Rivaroxaban Metformin may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ruxolitinib Ruxolitinib Metformin may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Vandetanib Vandetanib The serum concentration of Metformin can be increased when it is combined with Vandetanib.
Clobazam Clobazam Metformin may decrease the excretion rate of Clobazam which could result in a higher serum level.
Vemurafenib Vemurafenib The therapeutic efficacy of Metformin can be increased when used in combination with Vemurafenib.
Deferiprone Deferiprone Metformin may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Crizotinib Crizotinib The serum concentration of Metformin can be increased when it is combined with Crizotinib.
Naloxone Injection Naloxone Injection Metformin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Fondaparinux Injection Fondaparinux Injection Metformin may decrease the excretion rate of Fondaparinux which could result in a higher serum level.
Enzalutamide Enzalutamide Metformin may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron Mirabegron Metformin may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Corticotropin, Repository Injection Corticotropin, Repository Injection The therapeutic efficacy of Metformin can be decreased when used in combination with Corticotropin.
Lorcaserin Lorcaserin The risk or severity of hypoglycemia can be increased when Metformin is combined with Mecasermin.
Teduglutide Injection Teduglutide Injection Metformin may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Pomalidomide Pomalidomide Metformin may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
Methazolamide Methazolamide The risk or severity of lactic acidosis can be increased when Methazolamide is combined with Metformin.
Dabrafenib Dabrafenib The therapeutic efficacy of Metformin can be decreased when used in combination with Dabrafenib.
Trametinib Trametinib Metformin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Dolutegravir Dolutegravir The serum concentration of Metformin can be increased when it is combined with Dolutegravir.
Levomilnacipran Levomilnacipran The risk or severity of hypoglycemia can be increased when Metformin is combined with Levomilnacipran.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Metformin which could result in a higher serum level.
Vortioxetine Vortioxetine Metformin may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the excretion rate of Metformin which could result in a higher serum level.
Simeprevir Simeprevir The therapeutic efficacy of Metformin can be increased when used in combination with Simeprevir.
Sofosbuvir Sofosbuvir Metformin may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Apremilast Apremilast Metformin may decrease the excretion rate of Apremilast which could result in a higher serum level.
Droxidopa Droxidopa Metformin may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib Ceritinib The therapeutic efficacy of Metformin can be decreased when used in combination with Ceritinib.
Albiglutide Injection Albiglutide Injection The risk or severity of hypoglycemia can be increased when Metformin is combined with Albiglutide.
Testosterone Injection Testosterone Injection Metformin may decrease the excretion rate of Testosterone which could result in a higher serum level.
Dulaglutide Injection Dulaglutide Injection The risk or severity of hypoglycemia can be increased when Metformin is combined with Dulaglutide.
Edoxaban Edoxaban Metformin may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Methamphetamine Methamphetamine Metformin may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Tasimelteon Tasimelteon Metformin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Lanreotide Injection Lanreotide Injection The therapeutic efficacy of Metformin can be decreased when used in combination with Lanreotide.
Risperidone Injection Risperidone Injection The therapeutic efficacy of Metformin can be decreased when used in combination with Risperidone.
Palbociclib Palbociclib The risk or severity of adverse effects can be increased when Palbociclib is combined with Metformin.
Insulin Human Inhalation Insulin Human Inhalation The risk or severity of adverse effects can be increased when Insulin human is combined with Metformin.
Lenvatinib Lenvatinib The serum concentration of Metformin can be increased when it is combined with Lenvatinib.
Haloperidol Injection Haloperidol Injection The therapeutic efficacy of Metformin can be decreased when used in combination with Haloperidol.
Amiloride Amiloride The serum concentration of Metformin can be increased when it is combined with Amiloride.
Macitentan Macitentan Metformin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Prednisolone Prednisolone The therapeutic efficacy of Metformin can be decreased when used in combination with Prednisolone.
Brexpiprazole Brexpiprazole The therapeutic efficacy of Metformin can be decreased when used in combination with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The therapeutic efficacy of Metformin can be decreased when used in combination with Ziprasidone.
Penicillin G Procaine Injection Penicillin G Procaine Injection Metformin may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The risk or severity of adverse effects can be increased when Insulin degludec is combined with Metformin.
Ixazomib Ixazomib Metformin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Patiromer Patiromer Patiromer can cause a decrease in the absorption of Metformin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lesinurad Lesinurad Metformin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Metformin which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection The therapeutic efficacy of Metformin can be decreased when used in combination with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection Metformin may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
Diphenhydramine Injection Diphenhydramine Injection The serum concentration of Metformin can be increased when it is combined with Diphenhydramine.
Furosemide Injection Furosemide Injection The therapeutic efficacy of Metformin can be decreased when used in combination with Furosemide.
Rucaparib Rucaparib The excretion of Metformin can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection The risk or severity of hypoglycemia can be increased when Metformin is combined with Lixisenatide.
Brigatinib Brigatinib The excretion of Metformin can be decreased when combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) Doxepin may decrease the hypoglycemic activities of Metformin.
Deutetrabenazine Deutetrabenazine Metformin may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Metformin may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort Deflazacort The therapeutic efficacy of Metformin can be decreased when used in combination with Deflazacort.
Safinamide Safinamide Safinamide may increase the hypoglycemic activities of Metformin.
Naldemedine Naldemedine Metformin may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Enasidenib Enasidenib The serum concentration of Metformin can be increased when it is combined with Enasidenib.
Benznidazole Benznidazole Metformin may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection Copanlisib Injection The excretion of Metformin can be decreased when combined with Copanlisib.
Delafloxacin Delafloxacin The therapeutic efficacy of Metformin can be increased when used in combination with Delafloxacin.
Abemaciclib Abemaciclib The excretion of Abemaciclib can be decreased when combined with Metformin.
Semaglutide Injection Semaglutide Injection The risk or severity of hypoglycemia can be increased when Metformin is combined with Semaglutide.
Apalutamide Apalutamide The excretion of Metformin can be decreased when combined with Apalutamide.
Baricitinib Baricitinib The excretion of Baricitinib can be decreased when combined with Metformin.
Lofexidine Lofexidine The excretion of Metformin can be decreased when combined with Lofexidine.
Plazomicin Injection Plazomicin Injection Metformin may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Tafenoquine Tafenoquine The excretion of Metformin can be decreased when combined with Tafenoquine.
Dacomitinib Dacomitinib The risk or severity of adverse effects can be increased when Dacomitinib is combined with Metformin.
Stiripentol Stiripentol Metformin may decrease the excretion rate of Stiripentol which could result in a higher serum level.
Gilteritinib Gilteritinib The excretion of Metformin can be decreased when combined with Gilteritinib.
Glasdegib Glasdegib The excretion of Metformin can be decreased when combined with Glasdegib.
Rifamycin Rifamycin The excretion of Metformin can be decreased when combined with Rifamycin.
Prucalopride Prucalopride Metformin may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Metformin which could result in a higher serum level.
Erdafitinib Erdafitinib The serum concentration of Metformin can be increased when it is combined with Erdafitinib.
Solriamfetol Solriamfetol The serum concentration of Solriamfetol can be increased when it is combined with Metformin.
Pexidartinib Pexidartinib The excretion of Metformin can be decreased when combined with Pexidartinib.
Istradefylline Istradefylline The excretion of Metformin can be decreased when combined with Istradefylline.
Pitolisant Pitolisant The risk or severity of adverse effects can be increased when Pitolisant is combined with Metformin.
Fedratinib Fedratinib The excretion of Metformin can be decreased when combined with Fedratinib.
Tazemetostat Tazemetostat The excretion of Metformin can be decreased when combined with Tazemetostat.
Teprotumumab-trbw Injection Teprotumumab-trbw Injection The therapeutic efficacy of Metformin can be decreased when used in combination with Teprotumumab.
Tucatinib Tucatinib The excretion of Metformin can be decreased when combined with Tucatinib.
Remdesivir Injection Remdesivir Injection The excretion of Metformin can be decreased when combined with Remdesivir.
Ripretinib Ripretinib The excretion of Metformin can be decreased when combined with Ripretinib.
Selpercatinib Selpercatinib The excretion of Metformin can be decreased when combined with Selpercatinib.
Capmatinib Capmatinib The excretion of Metformin can be decreased when combined with Capmatinib.
Octreotide Octreotide The therapeutic efficacy of Metformin can be decreased when used in combination with Octreotide.
Pralsetinib Pralsetinib The excretion of Metformin can be decreased when combined with Pralsetinib.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The therapeutic efficacy of Metformin can be decreased when used in combination with Drospirenone.
Viloxazine Viloxazine Metformin may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Metformin which could result in a higher serum level.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Metformin which could result in a higher serum level.
Indomethacin Indomethacin Indomethacin may decrease the excretion rate of Metformin which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid Mefenamic acid may decrease the excretion rate of Metformin which could result in a higher serum level.
Naproxen Naproxen Naproxen may decrease the excretion rate of Metformin which could result in a higher serum level.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Metformin which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Metformin which could result in a higher serum level.
Isotretinoin Isotretinoin Metformin may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Metformin may decrease the excretion rate of Sucralfate which could result in a higher serum level.
Floxuridine Floxuridine Floxuridine may decrease the excretion rate of Metformin which could result in a higher serum level.
Metaxalone Metaxalone Metformin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection Methotrexate may decrease the excretion rate of Metformin which could result in a higher serum level.
Methsuximide Methsuximide The risk or severity of hypoglycemia can be increased when Methsuximide is combined with Metformin.
Chlorpromazine Chlorpromazine The therapeutic efficacy of Metformin can be decreased when used in combination with Chlorpromazine.
Diazepam Diazepam Metformin may decrease the excretion rate of Diazepam which could result in a higher serum level.
Oxazepam Oxazepam Metformin may decrease the excretion rate of Oxazepam which could result in a higher serum level.
Flurazepam Flurazepam The serum concentration of Metformin can be increased when it is combined with Flurazepam.
Clorazepate Clorazepate Metformin may decrease the excretion rate of Clorazepic acid which could result in a higher serum level.
Lorazepam Lorazepam Lorazepam may decrease the excretion rate of Metformin which could result in a higher serum level.
Phenoxybenzamine Phenoxybenzamine The serum concentration of Metformin can be increased when it is combined with Phenoxybenzamine.
Carmustine Carmustine Carmustine may decrease the excretion rate of Metformin which could result in a higher serum level.
Amantadine Amantadine The serum concentration of Amantadine can be increased when it is combined with Metformin.
Codeine Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Metformin.
Bromocriptine Bromocriptine The risk or severity of hypoglycemia can be increased when Metformin is combined with Bromocriptine.
Tranylcypromine Tranylcypromine Tranylcypromine may increase the hypoglycemic activities of Metformin.
Phenelzine Phenelzine Metformin may decrease the excretion rate of Phenelzine which could result in a higher serum level.
Procarbazine Procarbazine Procarbazine may increase the hypoglycemic activities of Metformin.
Tetracycline Tetracycline Metformin may decrease the excretion rate of Tetracycline which could result in a higher serum level.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Metformin which could result in a higher serum level.
Sulfadiazine Sulfadiazine The therapeutic efficacy of Metformin can be increased when used in combination with Sulfadiazine.
Methadone Methadone Metformin may decrease the excretion rate of Methadone which could result in a higher serum level.
Benztropine Benztropine Benzatropine may decrease the excretion rate of Metformin which could result in a higher serum level.
Maprotiline Maprotiline Metformin may decrease the excretion rate of Maprotiline which could result in a higher serum level.
Ibuprofen Ibuprofen Ibuprofen may decrease the excretion rate of Metformin which could result in a higher serum level.
Azathioprine Azathioprine Metformin may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Phentermine Phentermine The therapeutic efficacy of Metformin can be increased when used in combination with Phentermine.
Methylphenidate Methylphenidate Metformin may decrease the excretion rate of Methylphenidate which could result in a higher serum level.
Amoxapine Amoxapine Amoxapine may decrease the hypoglycemic activities of Metformin.
Sulfasalazine Sulfasalazine Sulfasalazine may increase the hypoglycemic activities of Metformin.
Hydrocortisone Hydrocortisone The therapeutic efficacy of Metformin can be decreased when used in combination with Hydrocortisone.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Metformin which could result in a higher serum level.
Carbamazepine Carbamazepine Metformin may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
Methyldopa Methyldopa Metformin may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Prazosin Prazosin The serum concentration of Prazosin can be increased when it is combined with Metformin.
Hydralazine Hydralazine Metformin may decrease the excretion rate of Hydralazine which could result in a higher serum level.
Cimetidine Cimetidine The serum concentration of Cimetidine can be increased when it is combined with Metformin.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Metformin which could result in a higher serum level.
Warfarin Warfarin Metformin may decrease the excretion rate of Warfarin which could result in a higher serum level.
Clonazepam Clonazepam Metformin may decrease the excretion rate of Clonazepam which could result in a higher serum level.
Loperamide Loperamide The risk or severity of hypoglycemia can be increased when Loperamide is combined with Metformin.
Promethazine Promethazine Metformin may decrease the excretion rate of Promethazine which could result in a higher serum level.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the excretion rate of Metformin which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Metformin may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Digoxin Digoxin The serum concentration of Digoxin can be increased when it is combined with Metformin.
Chloroquine Chloroquine Metformin may decrease the excretion rate of Chloroquine which could result in a higher serum level.
Quinine Quinine The risk or severity of hypoglycemia can be increased when Quinine is combined with Metformin.
Ethosuximide Ethosuximide The risk or severity of hypoglycemia can be increased when Ethosuximide is combined with Metformin.
Triamterene Triamterene Triamterene may decrease the excretion rate of Metformin which could result in a higher serum level.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Metformin can be decreased when used in combination with Chlorothiazide.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Metformin can be decreased when used in combination with Chlorthalidone.
Metolazone Metolazone The therapeutic efficacy of Metformin can be decreased when used in combination with Metolazone.
Isosorbide Isosorbide Isosorbide may increase the excretion rate of Metformin which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital Secobarbital Metformin may decrease the excretion rate of Secobarbital which could result in a higher serum level.
Desipramine Desipramine Desipramine may decrease the hypoglycemic activities of Metformin.
Amitriptyline Amitriptyline Amitriptyline may decrease the hypoglycemic activities of Metformin.
Imipramine Imipramine Imipramine may decrease the hypoglycemic activities of Metformin.
Probenecid Probenecid The therapeutic efficacy of Metformin can be increased when used in combination with Probenecid.
Quinidine Quinidine Quinidine may decrease the excretion rate of Metformin which could result in a higher serum level.
Procainamide Procainamide The excretion of Procainamide can be decreased when combined with Metformin.
Isoniazid Isoniazid Metformin may decrease the excretion rate of Isoniazid which could result in a higher serum level.
Pyrazinamide Pyrazinamide Metformin may decrease the excretion rate of Pyrazinamide which could result in a higher serum level.
Disopyramide Disopyramide The risk or severity of hypoglycemia can be increased when Disopyramide is combined with Metformin.
Butabarbital Butabarbital Butabarbital may decrease the excretion rate of Metformin which could result in a higher serum level.
Levothyroxine Levothyroxine The therapeutic efficacy of Metformin can be decreased when used in combination with Levothyroxine.
Liothyronine Liothyronine The therapeutic efficacy of Metformin can be decreased when used in combination with Liothyronine.
Methimazole Methimazole Metformin may decrease the excretion rate of Methimazole which could result in a higher serum level.
Chlorpropamide Chlorpropamide The risk or severity of hypoglycemia can be increased when Metformin is combined with Chlorpropamide.
Tolbutamide Tolbutamide The risk or severity of hypoglycemia can be increased when Metformin is combined with Tolbutamide.
Tolazamide Tolazamide The risk or severity of hypoglycemia can be increased when Metformin is combined with Tolazamide.
Dinoprostone Dinoprostone The serum concentration of Metformin can be increased when it is combined with Dinoprostone.
Niacin Niacin The therapeutic efficacy of Metformin can be decreased when used in combination with Niacin.
Baclofen Baclofen The therapeutic efficacy of Metformin can be decreased when used in combination with Baclofen.
Chlorpheniramine Chlorpheniramine The serum concentration of Metformin can be increased when it is combined with Chlorpheniramine.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Metformin which could result in a higher serum level.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Metformin can be decreased when used in combination with Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Metformin can be decreased when used in combination with Hydrochlorothiazide.
Chlorzoxazone Chlorzoxazone Metformin may decrease the excretion rate of Chlorzoxazone which could result in a higher serum level.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Metformin which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Metformin which could result in a higher serum level.
Danazol Danazol The therapeutic efficacy of Metformin can be decreased when used in combination with Danazol.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The therapeutic efficacy of Metformin can be increased when used in combination with Propranolol.
Pseudoephedrine Pseudoephedrine The therapeutic efficacy of Metformin can be decreased when used in combination with Pseudoephedrine.
Nortriptyline Nortriptyline Nortriptyline may decrease the hypoglycemic activities of Metformin.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Metformin which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Metformin which could result in a higher serum level.
Phytonadione Phytonadione Metformin may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Metformin which could result in a higher serum level.
Nadolol Nadolol The therapeutic efficacy of Nadolol can be increased when used in combination with Metformin.
Allopurinol Allopurinol Metformin may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Fluoxymesterone Fluoxymesterone Fluoxymesterone may increase the hypoglycemic activities of Metformin.
Flavoxate Flavoxate Metformin may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Colchicine Colchicine Metformin may decrease the excretion rate of Colchicine which could result in a higher serum level.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Metformin which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Metformin which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Metformin which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Metformin which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Metformin which could result in a higher serum level.
Dacarbazine Dacarbazine Metformin may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Acetazolamide Acetazolamide The risk or severity of lactic acidosis can be increased when Acetazolamide is combined with Metformin.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Metformin which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Metformin which could result in a higher serum level.
Pyrantel Pyrantel Metformin may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Captopril Captopril The risk or severity of lactic acidosis can be increased when Captopril is combined with Metformin.
Ethacrynic Acid Ethacrynic Acid The therapeutic efficacy of Metformin can be decreased when used in combination with Etacrynic acid.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Metformin which could result in a higher serum level.
Metoprolol Metoprolol The therapeutic efficacy of Metformin can be increased when used in combination with Metoprolol.
Aspirin Aspirin The risk or severity of hypoglycemia can be increased when Acetylsalicylic acid is combined with Metformin.
Salsalate Salsalate Salsalate may decrease the excretion rate of Metformin which could result in a higher serum level.
Alprazolam Alprazolam Metformin may decrease the excretion rate of Alprazolam which could result in a higher serum level.
Temazepam Temazepam Temazepam may decrease the excretion rate of Metformin which could result in a higher serum level.
Triazolam Triazolam Metformin may decrease the excretion rate of Triazolam which could result in a higher serum level.
Dicyclomine Dicyclomine Metformin may decrease the excretion rate of Dicyclomine which could result in a higher serum level.
Propantheline Propantheline Metformin may decrease the excretion rate of Propantheline which could result in a higher serum level.
Trimethoprim Trimethoprim The serum concentration of Metformin can be increased when it is combined with Trimethoprim.
Diltiazem Diltiazem The risk or severity of hypoglycemia can be increased when Diltiazem is combined with Metformin.
Nifedipine Nifedipine The risk or severity of hypoglycemia can be increased when Nifedipine is combined with Metformin.
Timolol Timolol The therapeutic efficacy of Timolol can be increased when used in combination with Metformin.
Verapamil Verapamil The risk or severity of adverse effects can be increased when Verapamil is combined with Metformin.
Atenolol Atenolol The serum concentration of Metformin can be increased when it is combined with Atenolol.
Pindolol Pindolol The therapeutic efficacy of Pindolol can be increased when used in combination with Metformin.
Cisplatin Injection Cisplatin Injection The serum concentration of Cisplatin can be increased when it is combined with Metformin.
Diflunisal Diflunisal Diflunisal may increase the hypoglycemic activities of Metformin.
Piroxicam Piroxicam Piroxicam may decrease the excretion rate of Metformin which could result in a higher serum level.
Bumetanide Bumetanide The therapeutic efficacy of Metformin can be decreased when used in combination with Bumetanide.
Indapamide Indapamide The therapeutic efficacy of Metformin can be decreased when used in combination with Indapamide.
Amoxicillin Amoxicillin Metformin may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Metformin may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline Pentoxifylline Metformin may decrease the excretion rate of Pentoxifylline which could result in a higher serum level.
Pentamidine Injection Pentamidine Injection The therapeutic efficacy of Metformin can be decreased when used in combination with Pentamidine.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Metformin which could result in a higher serum level.
Labetalol Labetalol The therapeutic efficacy of Labetalol can be increased when used in combination with Metformin.
Auranofin Auranofin Metformin may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection The therapeutic efficacy of Metformin can be decreased when used in combination with Leuprolide.
Gemfibrozil Gemfibrozil Metformin may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Metformin which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Metformin which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Metformin which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Metformin which could result in a higher serum level.
Enalapril Enalapril The risk or severity of lactic acidosis can be increased when Enalapril is combined with Metformin.
Flurbiprofen Flurbiprofen Flurbiprofen may decrease the excretion rate of Metformin which could result in a higher serum level.
Amiodarone Amiodarone The serum concentration of Metformin can be increased when it is combined with Amiodarone.
Aztreonam Injection Aztreonam Injection Metformin may decrease the excretion rate of Aztreonam which could result in a higher serum level.
Buspirone Buspirone Metformin may decrease the excretion rate of Buspirone which could result in a higher serum level.
Lovastatin Lovastatin Metformin may increase the hypolipidaemic activities of Lovastatin.
Ciprofloxacin Ciprofloxacin The therapeutic efficacy of Metformin can be increased when used in combination with Ciprofloxacin.
Mesalamine Mesalamine Mesalazine may increase the hypoglycemic activities of Metformin.
Diclofenac Diclofenac Diclofenac may decrease the excretion rate of Metformin which could result in a higher serum level.
Fluoxetine Fluoxetine The risk or severity of hypoglycemia can be increased when Fluoxetine is combined with Metformin.
Nimodipine Nimodipine The risk or severity of hypoglycemia can be increased when Nimodipine is combined with Metformin.
Clozapine Clozapine The therapeutic efficacy of Metformin can be decreased when used in combination with Clozapine.
Estazolam Estazolam Metformin may decrease the excretion rate of Estazolam which could result in a higher serum level.
Ofloxacin Ofloxacin The therapeutic efficacy of Metformin can be increased when used in combination with Ofloxacin.
Didanosine Didanosine Metformin may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Metformin may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Benazepril Benazepril The risk or severity of hypoglycemia can be increased when Benazepril is combined with Metformin.
Etodolac Etodolac Etodolac may decrease the excretion rate of Metformin which could result in a higher serum level.
Felodipine Felodipine The risk or severity of hypoglycemia can be increased when Felodipine is combined with Metformin.
Fosinopril Fosinopril The risk or severity of lactic acidosis can be increased when Fosinopril is combined with Metformin.
Nabumetone Nabumetone Nabumetone may decrease the excretion rate of Metformin which could result in a higher serum level.
Pravastatin Pravastatin Metformin may increase the hypolipidaemic activities of Pravastatin.
Quinapril Quinapril The risk or severity of lactic acidosis can be increased when Quinapril is combined with Metformin.
Ramipril Ramipril The risk or severity of lactic acidosis can be increased when Ramipril is combined with Metformin.
Simvastatin Simvastatin Metformin may increase the hypolipidaemic activities of Simvastatin.
Amlodipine Amlodipine The risk or severity of hypoglycemia can be increased when Amlodipine is combined with Metformin.
Lisinopril Lisinopril The risk or severity of lactic acidosis can be increased when Lisinopril is combined with Metformin.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Metformin which could result in a higher serum level.
Sotalol Sotalol The risk or severity of hypoglycemia can be increased when Sotalol is combined with Metformin.
Bisoprolol Bisoprolol The therapeutic efficacy of Bisoprolol can be increased when used in combination with Metformin.
Doxazosin Doxazosin The risk or severity of adverse effects can be increased when Doxazosin is combined with Metformin.
Isradipine Isradipine The risk or severity of hypoglycemia can be increased when Isradipine is combined with Metformin.
Fluvastatin Fluvastatin Metformin may increase the hypolipidaemic activities of Fluvastatin.
Venlafaxine Venlafaxine The risk or severity of hypoglycemia can be increased when Venlafaxine is combined with Metformin.
Fluvoxamine Fluvoxamine The risk or severity of hypoglycemia can be increased when Fluvoxamine is combined with Metformin.
Nefazodone Nefazodone The risk or severity of hypoglycemia can be increased when Metformin is combined with Nefazodone.
Lamotrigine Lamotrigine The serum concentration of Metformin can be increased when it is combined with Lamotrigine.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Metformin which could result in a higher serum level.
Tramadol Tramadol Tramadol may decrease the excretion rate of Metformin which could result in a higher serum level.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Metformin which could result in a higher serum level.
Moexipril Moexipril The risk or severity of lactic acidosis can be increased when Moexipril is combined with Metformin.
Ifosfamide Injection Ifosfamide Injection Metformin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Nicardipine Nicardipine The risk or severity of hypoglycemia can be increased when Nicardipine is combined with Metformin.
Bupropion Bupropion The excretion of Metformin can be decreased when combined with Bupropion.
Ticlopidine Ticlopidine Ticlopidine may decrease the excretion rate of Metformin which could result in a higher serum level.
Saquinavir Saquinavir The therapeutic efficacy of Metformin can be decreased when used in combination with Saquinavir.
Nisoldipine Nisoldipine The risk or severity of hypoglycemia can be increased when Metformin is combined with Nisoldipine.
Lamivudine Lamivudine The serum concentration of Lamivudine can be increased when it is combined with Metformin.
Acarbose Acarbose The risk or severity of hypoglycemia can be increased when Acarbose is combined with Metformin.
Glimepiride Glimepiride The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Metformin.
Gemcitabine Injection Gemcitabine Injection Metformin may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Indinavir Indinavir The therapeutic efficacy of Metformin can be decreased when used in combination with Indinavir.
Ritonavir Ritonavir The therapeutic efficacy of Metformin can be decreased when used in combination with Ritonavir.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Metformin which could result in a higher serum level.
Meropenem Injection Meropenem Injection Metformin may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine Clomipramine Clomipramine may decrease the hypoglycemic activities of Metformin.
Fosfomycin Fosfomycin Metformin may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Trandolapril Trandolapril The risk or severity of lactic acidosis can be increased when Trandolapril is combined with Metformin.
Topiramate Topiramate The risk or severity of adverse effects can be increased when Topiramate is combined with Metformin.
Insulin Lispro Injection Insulin Lispro Injection The risk or severity of adverse effects can be increased when Insulin lispro is combined with Metformin.
Pramipexole Pramipexole The serum concentration of Pramipexole can be increased when it is combined with Metformin.
Nelfinavir Nelfinavir The therapeutic efficacy of Metformin can be decreased when used in combination with Nelfinavir.
Carvedilol Carvedilol The therapeutic efficacy of Metformin can be increased when used in combination with Carvedilol.
Nilutamide Nilutamide Metformin may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Flutamide Flutamide Metformin may decrease the excretion rate of Flutamide which could result in a higher serum level.
Selegiline Selegiline Selegiline may increase the hypoglycemic activities of Metformin.
Sertraline Sertraline The risk or severity of hypoglycemia can be increased when Sertraline is combined with Metformin.
Propafenone Propafenone The therapeutic efficacy of Metformin can be increased when used in combination with Propafenone.
Tamsulosin Tamsulosin The therapeutic efficacy of Tamsulosin can be increased when used in combination with Metformin.
Quetiapine Quetiapine The therapeutic efficacy of Metformin can be decreased when used in combination with Quetiapine.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Metformin which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Metformin which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Metformin which could result in a higher serum level.
Cetirizine Cetirizine Metformin may decrease the excretion rate of Cetirizine which could result in a higher serum level.
Paroxetine Paroxetine The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Metformin.
Tolcapone Tolcapone Tolcapone may decrease the excretion rate of Metformin which could result in a higher serum level.
Citalopram Citalopram The risk or severity of hypoglycemia can be increased when Citalopram is combined with Metformin.
Capecitabine Capecitabine Metformin may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Efavirenz Efavirenz The risk or severity of adverse effects can be increased when Efavirenz is combined with Metformin.
Abacavir Abacavir Metformin may decrease the excretion rate of Abacavir which could result in a higher serum level.
Celecoxib Celecoxib The therapeutic efficacy of Metformin can be increased when used in combination with Celecoxib.
Tolterodine Tolterodine Metformin may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Metformin which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may increase the hypoglycemic activities of Metformin.
Nateglinide Nateglinide The risk or severity of hypoglycemia can be increased when Metformin is combined with Nateglinide.
Rabeprazole Rabeprazole Metformin may decrease the excretion rate of Rabeprazole which could result in a higher serum level.

* This branded product is no longer on the market. Generic alternatives may be available.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists