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Dihydroergotamine Injection

Dihydroergotamine Injection is an ergot-type medicine used to stop migraine attacks and cluster headaches once they have started.

Brand names DHE-45 InjectionTrudhesaAtzumiBrekiyaMigranal
Drug class Ergotamine Derivative
Rx Form 1
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 8 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 5, 2026 🚨Recall on record
Other forms & routes:
Dihydroergotamine Injection at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Dihydroergotamine Injection is a decades-old ergot medicine, available generically, that stops migraine and cluster headache attacks in adults by acting on serotonin receptors to narrow blood vessels around the brain and calm pain nerves, usually after triptans have failed. An occasional dose is usually well tolerated, with flushing, dizziness, tingling and diarrhea the common complaints. Its boxed warning forbids strong CYP3A4 blockers (drugs that slow its breakdown), such as clarithromycin, erythromycin, ritonavir or ketoconazole, because levels rise and blood vessels can clamp down, cutting off blood flow to the brain, fingers or toes. Use it for attacks only, never for prevention or daily, and only after a heart check.

Clinical pearls

  • Keep sumatriptan and other triptans, and any other ergot medicine, at least 24 hours away from a dose.
  • Grapefruit juice, fluconazole and fluoxetine can also raise its levels, so mention them before using it.
  • Nicotine from smoking, vaping or patches narrows blood vessels further and adds to the risk of poor circulation.
  • Avoid it in pregnancy, and pump and discard breast milk during treatment and for 3 days after the last dose.
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

Do not use dihydroergotamine with strong CYP3A4 inhibitors. These include certain HIV medicines (protease inhibitors) and macrolide antibiotics. They raise dihydroergotamine levels in the blood.

Higher levels can cause severe blood vessel spasm, cutting off blood flow to the brain or to the arms and legs. This can be serious or life-threatening. Warning signs include cold, numb, pale, or bluish fingers or toes, and stroke symptoms. Always tell your prescriber and pharmacist about every medicine you take.

Read the full warning on DailyMed →
How you get itPrescription only
Comes asInjection
Earliest FDA record1946
Companies listing it with the FDA6
FDA label last updatedOct 4, 2025
FDA’s strongest warning (boxed)Yes, read the warning

Patient information guide A plain-language walkthrough of Dihydroergotamine Injection, written from its FDA label.

What Dihydroergotamine Injection is used for

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Dihydroergotamine Injection is used to treat headache attacks in adults.

  • Acute treatment of migraine with or without aura (Brekiya).
  • Acute treatment of cluster headaches (Brekiya).
  • Brekiya is not approved for migraine prevention, hemiplegic migraine, or migraine with brainstem aura.

How Dihydroergotamine Injection works

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Dihydroergotamine binds strongly to serotonin receptors, especially 5-HT1D. It also binds to other serotonin, noradrenaline, and dopamine receptors.

Its migraine relief is thought to come from narrowing blood vessels inside the head and from calming pain nerves that release inflammatory chemicals. It also has oxytocic properties, meaning it can stimulate the uterus.

Dihydroergotamine Injection dosage

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Brekiya is a single-dose autoinjector given under the skin of the middle thigh when a headache attack occurs. If needed, the dose may be repeated after an hour, within daily and weekly maximums on the label. Do not use it daily over the long term.

  • Rotate sites and stay at least 2 inches from your last injection.
  • Check that the liquid is clear and colorless.
  • The injection takes about 10 seconds. The window turns fully blue when the dose is done.

Follow your prescriber's directions and the Instructions for Use.

Dosing details from the FDA-approved label

From the Dihydroergotamine Injection prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Acute treatment (BREKIYA autoinjector, subcutaneous injection only)
    • 1 mg administered subcutaneously via a single 1 mL autoinjector
    • The dose may be repeated, as needed, at 1-hour intervals
    • Maximum: Do not exceed 3 mg (3 doses) in a 24-hour period; do not exceed 6 mg (6 doses) total in a week
    • Cardiovascular evaluation recommended before first dose; for patients with risk factors predictive of coronary artery disease, first dose strongly recommended in an equipped healthcare facility
Read the label’s full dosing text

2 DOSAGE AND ADMINISTRATION For subcutaneous injection only. ( 2.1 ) Recommended dosage is 1 mg administered subcutaneously as a single 1 mL autoinjector. ( 2.1 ) Do not exceed 3 mg (3 doses) in a 24-hour period. ( 2.1 ) Do not exceed 6 mg (6 doses) in a week. ( 2.1 ) Prior to initiation, a cardiovascular evaluation is recommended. ( 2.2 ) 2.1 Recommended Dosage BREKIYA autoinjector is for subcutaneous injection only. The recommended dose of BREKIYA is 1 mg administered subcutaneously via a single 1 mL autoinjector. The dose may be repeated, as needed, at 1-hour intervals to a total maximum of 3 mg (3 doses) in a 24-hour period. Do not exceed 6 mg (6 doses) total in a week. 2.2 Assessment Prior to First Dose Prior to initiation of BREKIYA, a cardiovascular evaluation is recommended [see Warnings and Precautions (5.3) ] . For patients with risk factors predictive of coronary artery disease who are determined to have a satisfactory cardiovascular evaluation, it is strongly recommended that administration of the first dose of BREKIYA take place in the setting of an equipped healthcare facility. 2.3 Important Administration Instructions See the “Instructions for Use” for detailed steps for administering the subcutaneous injection using the autoinjector. Preparation BREKIYA is a prefilled, single-dose disposable autoinjector intended to be given subcutaneously into the skin of the middle thigh. Rotate injection sites. Choose an injection site at least 2 inches away from the last injection site. Do not inject into moles, scars, birthmarks, or areas where the skin is tender, bruised, red, or hard. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Carefully examine the liquid medication for discoloration, cloudiness, floating flakes or particles. Administer only if clear and colorless. Administration Remove the red needle cap by pulling it straight off. Position the autoinjector straight onto the cleaned injection site with the white safety guard resting on the skin. Push the autoinjector down and press and release the gray activation button to start the injection. A “click” will sound when the injection starts.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Dihydroergotamine Injection side effects

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Reported side effects include:

Common side effects

  • Dizziness
  • Headache
  • Flushing
  • Diarrhea
  • Rash
  • Increased sweating
  • Anxiety
  • Tingling or numbness (paresthesia)

When to get medical help

  • Get emergency help for chest pain, a racing or irregular heartbeat, or shortness of breath. These can signal a heart attack or a dangerous heart rhythm.
  • Get emergency help for signs of stroke or brain bleeding, such as sudden severe headache, weakness, or trouble speaking.
  • Stop the medicine and call your provider if your fingers or toes feel cold, numb, pale, or bluish, or if you have muscle pains. These can signal narrowed blood vessels.
  • Call your provider if you have severe stomach pain or other signs of reduced blood flow, such as ischemic bowel syndrome or Raynaud's syndrome.
  • Call your provider if you develop very high blood pressure.
  • Tell your provider if you have headaches on most days after using migraine medicines 10 or more days a month. This may be medication overuse headache.
  • Call your provider about persistent breathlessness, back or flank pain, or other problems after long daily use. Fibrosis (scar-like tissue buildup) has been reported with prolonged daily use.

Dihydroergotamine Injection warnings and precautions

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  • Strong CYP3A4 inhibitors: boxed warning for severe reduced blood flow.
  • Heart risks: heart attack, dangerous rhythms, and coronary artery spasm, some fatal.
  • Brain risks: stroke and brain bleeding have been reported.
  • Vasospasm: can cause gangrene in people with poor circulation.
  • Blood pressure: can rise significantly.
  • Overuse: medication overuse headache and fibrosis with prolonged daily use.
  • Pregnancy: may cause preterm labor.

Dihydroergotamine Injection interactions

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Several medicines can make dihydroergotamine dangerous.

  • Strong CYP3A4 inhibitors (such as ritonavir, clarithromycin, ketoconazole): contraindicated because of dangerous blood vessel spasm.
  • Moderate or weaker CYP3A4 inhibitors, including grapefruit juice: use with caution.
  • Triptans, other ergot medicines, and methysergide: not within 24 hours of each other because of additive vessel narrowing.
  • Vasoconstrictors: contraindicated because blood pressure can spike.
  • Beta blockers and nicotine: may worsen vessel narrowing.
  • SSRIs: rare weakness, overactive reflexes, and poor coordination.

Interactions listed in the FDA-approved label

From the Dihydroergotamine Injection prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Strong CYP3A4 inhibitors: Rare serious adverse events with intravenous dihydroergotamine and strong CYP3A4 inhibitors resulted in vasospasm that led to cerebral ischemia and/or ischemia of the extremities. Use with BREKIYA is contraindicated.
  • Moderate CYP3A4 inhibitors: The label groups these with CYP3A4 inhibitors that may raise the risk of serious vasospastic adverse events. Administer with caution.
  • Triptans (5-HT1B/1D receptor agonists): Triptans have been reported to cause coronary artery vasospasm, and the effect could be additive with BREKIYA. Triptans and BREKIYA should not be taken within 24 hours of each other.
  • Beta blockers (propranolol): Propranolol may potentiate the vasoconstrictive action of ergotamine by blocking the vasodilating property of epinephrine.
  • Peripheral and central vasoconstrictors: The combination may cause synergistic elevation of blood pressure. Use with BREKIYA is contraindicated.
  • Nicotine: Nicotine may provoke vasoconstriction in some patients, predisposing to a greater ischemic response to ergot therapy.
  • Selective serotonin reuptake inhibitors (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline): Weakness, hyperreflexia, and incoordination have been reported rarely when 5-HT1 agonists were co-administered with SSRIs.
Read the label’s full interactions text

7 DRUG INTERACTIONS Beta Blockers/Nicotine: May potentiate/provoke vasoconstriction. ( 7.3 , 7.5 ) Selective Serotonin Reuptake Inhibitors: Weakness, hyperreflexia, and incoordination may occur with coadministration. ( 7.6 ) 7.1 CYP3A4 Inhibitors There have been rare reports of serious adverse events in connection with the coadministration of intravenous administration of dihydroergotamine and strong CYP3A4 inhibitors resulting in vasospasm that led to cerebral ischemia and/or ischemia of the extremities [see Warnings and Precautions (5.1) ]. The use of strong CYP3A4 inhibitors with BREKIYA is contraindicated [see Contraindications (4) ]. Administer moderate CYP3A4 inhibitors with caution. 7.2 Triptans Triptans (serotonin [5-HT 1B/1D receptor agonists) have been reported to cause coronary artery vasospasm, and its effect could be additive with BREKIYA. Therefore, triptans and BREKIYA should not be taken within 24 hours of each other [see Contraindications (4) ]. 7.3 Beta Blockers There have been reports that propranolol may potentiate the vasoconstrictive action of ergotamine by blocking the vasodilating property of epinephrine. 7.4 Vasoconstrictors BREKIYA is contraindicated for use with peripheral and central vasoconstrictors because the combination may cause synergistic elevation of blood pressure [see Warnings and Precautions (5.5) ]. 7.5 Nicotine Nicotine may provoke vasoconstriction in some patients, predisposing to a greater ischemic response to ergot therapy [see Warnings and Precautions (5.4) ] . 7.6 Selective Serotonin Reuptake Inhibitors Weakness, hyperreflexia, and incoordination have been reported rarely when 5-HT 1 agonists have been co-administered with selective serotonin reuptake inhibitors (SSRI’s) (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline).

Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

Before taking Dihydroergotamine Injection

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  • Do not use with heart disease, angina, past heart attack, or coronary artery spasm.
  • Do not use with uncontrolled high blood pressure, peripheral arterial disease, sepsis, or after vascular surgery.
  • Do not use with severe liver or kidney impairment.
  • Do not use with ergot or latex allergy (Brekiya).
  • A heart check is recommended first. People with risk factors should have the first dose in a medical setting.
  • Avoid in pregnancy.
  • Do not breastfeed during treatment and for 3 days after the last dose.
  • Not established for children.
  • Older adults need cautious dosing.

Dihydroergotamine Injection overdose

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Too much dihydroergotamine can cause ergotism, which means blood vessel spasm with numbness, tingling, pain, and bluish discoloration of the hands and feet. Other signs may include blood pressure changes, confusion, seizures, and nausea. Treatment includes stopping the drug, warming the affected area, vasodilators, and care to protect tissue. Contact a Poison Control Center or seek emergency care.

What Dihydroergotamine Injection does in the body

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Dihydroergotamine can raise blood pressure significantly, even in people with no history of high blood pressure. It also has oxytocic properties, meaning it can stimulate the uterus.

How your body processes Dihydroergotamine Injection

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Absorption from subcutaneous and intramuscular injection appeared similar, and it is poorly absorbed by mouth. About 93% of the drug is bound to proteins in the blood. It is mostly cleared by the liver and eliminated through bile in the feces, with only a small amount in urine. After intramuscular or intravenous use, the terminal half-life is about 9 hours.

How to store Dihydroergotamine Injection

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Store at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C to 30°C (59°F to 86°F) . Do not refrigerate or freeze.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

156

Supplements & herbs that interact with Dihydroergotamine Injection

156 supplements and herbal products have documented interactions with Dihydroergotamine Injection in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 4
  • Moderate · 110
  • Minor · 42
Every supplement checked against Dihydroergotamine Injection — ranked by severity The full interaction hub: 4 major · 110 moderate · 42 minor · every one linked to its full report. Check Dihydroergotamine Injection against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

Dihydroergotamine Injection: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Dihydroergotamine Injection — the kind of thing our pharmacy team would talk through with you at the counter.

What is this injection for?

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It stops migraine attacks and cluster headaches in adults once they start. It is not for preventing attacks. Brekiya also isn't for hemiplegic migraine or migraine with brainstem aura.

How do I use Brekiya?

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It is a prefilled autoinjector that goes under the skin of your middle thigh. Rotate sites and use it only if the liquid is clear and colorless. Stay within the daily and weekly limits your prescriber gives you.

What side effects should I expect?

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Some people get dizziness, headache, flushing, diarrhea, rash, sweating, anxiety, or tingling. Call right away for chest pain, stroke symptoms, or cold, pale, or numb fingers or toes.

What medicines should I avoid with it?

▾
Strong CYP3A4 inhibitors are off limits. These include certain HIV medicines and antibiotics such as clarithromycin and erythromycin, and antifungals like ketoconazole. Also avoid triptans and other ergot medicines within 24 hours. Tell me about everything you take.

Can I use it if I'm pregnant or breastfeeding?

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Avoid it during pregnancy, since it may cause preterm labor. Don't breastfeed while using it and for 3 days after your last dose. Pump and discard your milk during that time.

Why might I need a heart check first?

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This medicine can cause serious heart problems, including heart attack and dangerous rhythms. A heart evaluation is recommended before starting. If you have risk factors, your first dose should be given in a medical setting.

Is Dihydroergotamine Injection available over the counter?

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No. Dihydroergotamine Injection is a prescription medicine: every Dihydroergotamine Injection product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Dihydroergotamine Injection first available?

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The earliest FDA record we hold for Dihydroergotamine Injection is from 1946: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Dihydroergotamine Injection was first used.

Who makes Dihydroergotamine Injection?

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6 companies currently list Dihydroergotamine Injection products in the FDA's NDC Directory, including Hikma Pharmaceuticals USA Inc., Amneal Pharmaceuticals LLC, Baxter Healthcare Corporation. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Dihydroergotamine Injection on HelloPharmacist

Detailed data & references for Dihydroergotamine Injection Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Dihydroergotamine Injection forms and strengths (how it comes)

Dihydroergotamine Injection is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Dihydroergotamine Injection inactive ingredients by manufacturer.

Injection

Into a muscle · Into a vein · Under the skin
Brands Brekiya
How this form is used
What it may be used for
  • Brekiya is used for acute treatment of migraine with or without aura in adults.
  • Brekiya is used for acute treatment of cluster headaches in adults.
  • Brekiya is not for migraine prevention, hemiplegic migraine, or migraine with brainstem aura.
Important instructions
  • Brekiya is a prefilled single-dose autoinjector for subcutaneous injection only, into the middle thigh.
  • Brekiya injection sites should be rotated and kept away from moles, scars, or tender, bruised, red, or hard skin.
  • Brekiya should be used only if the liquid is clear and colorless.
Available strengths 1 strength
10 FDA-listed product records ⓘ

Dihydroergotamine Injection on the U.S. market: products, makers and brands

How Dihydroergotamine Injection appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

6 companies list 7 Dihydroergotamine Injection product records with the FDA, mostly as injection; the earliest marketing or approval year on record is 1946. Brand names on the directory include DHE-45 Injection, Trudhesa, Atzumi and 2 more; the rest are generics.

1
Dose forms ⓘ
6
Labelers (makers, repackagers, distributors)
2
Brand names
7
FDA-listed product records ⓘ
1946
Earliest FDA record ⓘ
Hikma Pharmaceuticals USA Inc.29%
Amneal Pharmaceuticals LLC14%
Baxter Healthcare Corporation14%
Gland Pharma Limited14%
Milla Pharmaceuticals Inc.14%
Provepharm Inc.14%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Dihydroergotamine Injection is used (Medicaid data)

A general measure of how commonly Dihydroergotamine Injection is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Dihydroergotamine Injection is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

201
Medicaid prescriptions filled (Q1–Q4 2025)
$26,719 gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Dihydroergotamine Injection prescribed? Of the 1,601 medications we measure, Dihydroergotamine Injection ranks #1,447 by Medicaid prescriptions — more than 10% of them.

Where Dihydroergotamine Injection ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5

Utilization by Dihydroergotamine Injection product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

1 ML dihydroergotamine mesylate 1 MG/ML Injection

201 Medicaid prescriptions (Q1–Q4 2025) 100% of Dihydroergotamine Injection prescriptions shown $26,719 gross reimbursement (before rebates) ≈ $133 per prescription (gross)

Summed across the 3 of 19 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 861672

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Dihydroergotamine Injection, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 3 of 19 listed Dihydroergotamine Injection NDCs with Medicaid activity.

Compare Dihydroergotamine Injection products

A representative set of FDA-listed product records for Dihydroergotamine Injection — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Strength Route Manufacturer / Labeler Category ⓘ Details
💊Injection
1 mg/mL Subcutaneous Amneal Pharmaceuticals LLC NDA View NDC →
1 mg/mL Intramuscular, Intravenous, Subcutaneous Baxter Healthcare Corporation ANDA View NDC →
1 mg/mL Intramuscular, Intravenous, Subcutaneous Gland Pharma Limited ANDA View NDC →
1 mg/mL Intramuscular, Intravenous, Subcutaneous Hikma Pharmaceuticals USA Inc. × 2 listings ANDA View NDC →
1 mg/mL Intramuscular, Intravenous, Subcutaneous Milla Pharmaceuticals Inc. ANDA View NDC →
1 mg/mL Intramuscular, Intravenous, Subcutaneous Provepharm Inc. ANDA View NDC →

Showing 7 of 7 products — FDA National Drug Code Directory. See every product, package size and price: browse all 7 Dihydroergotamine Injection NDCs →

Dihydroergotamine Injection recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list one Dihydroergotamine recall since July 2021. It is still ongoing. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.

Ongoing Class II Nov 22, 2024 · Provepharm Inc.
Discoloration
  • Dihydroergotamine Mesylate Injection, solution for injection, USP, 1 mg/mL Ampules, Rx Only, Distributed by: Provepharm Inc. 100 Springhouse Drive Suite 105, Collegeville, PA 19426, NDC 81284-411-05 Lots: Lot #: F9026F01, F9026F02, Exp. Date 12/2025 FDA record D-0150-2025 →

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Dihydroergotamine Injection RxCUI 3418 6 dose forms · 8 strengths
  1. Dose form (SCDF) Nasal Powder RxCUI 2714186 No current FDA listing
    Clinical drug / strength (SCD) 5.2 MG RxCUI 2714187
  2. Dose form (SCDF) Oral Tablet RxCUI 371844 No current FDA listing
    Clinical drug / strength (SCD) mesylate 1 MG RxCUI 1233876
  3. Dose form (SCDF) Sublingual Tablet RxCUI 608727 No current FDA listing
    Clinical drug / strength (SCD) mesylate 0.5 MG RxCUI 1233874 mesylate 1 MG RxCUI 1233880

Look up RxCUI 3418 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

Dihydroergotamine Injection brand names

Dihydroergotamine Injection is sold under 5 brand names in the FDA directory — DHE-45 Injection, Trudhesa, Atzumi, Brekiya and others. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

DHE-45 Injection Trudhesa Atzumi Brekiya Migranal

Who makes Dihydroergotamine Injection: manufacturers and labelers

6 companies list Dihydroergotamine Injection products with the FDA. By number of product records, the largest are Hikma Pharmaceuticals USA Inc., Amneal Pharmaceuticals LLC, Baxter Healthcare Corporation. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Hikma Pharmaceuticals USA Inc. 2 Amneal Pharmaceuticals LLC 1 Baxter Healthcare Corporation 1 Gland Pharma Limited 1 Milla Pharmaceuticals Inc. 1 Provepharm Inc. 1

Dihydroergotamine Injection drug class (RxNorm)

Dihydroergotamine Injection belongs to the Ergotamine Derivative class.

Pharmacologic class Ergotamine Derivative
Drug family (ATC) Ergot alkaloids

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Dihydroergotamine Injection page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Oct 4, 2025
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Dihydroergotamine Injection.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Dihydroergotamine Injection after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
8
Finished products in the current FDA directory
7
Companies listing them (makers, repackagers, distributors)
6
FDA labeler codes behind them ⓘ
6
Linked representative label ⓘ
Amneal Pharmaceuticals LLC
Linked label effective
Oct 4, 2025
Composite sections available
25
Linked SPL Set ID
cdbf5619-767f-4165-aec2-17bdd92d9ca2
Linked SPL Document ID
1d8fa8b1-75e6-42af-863d-a775791da7a6
Open the linked representative label on DailyMed ↗
NDC package records associated with this linked SPL 1

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Amneal Pharmaceuticals LLC is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →