Modafinil

Generic name: Pronounced as (moe daf' i nil)
Brand names
  • Provigil®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 02/15/2016

Modafinil is used to treat excessive sleepiness caused by narcolepsy (a condition that causes excessive daytime sleepiness) or shift work sleep disorder (sleepiness during scheduled waking hours and difficulty falling asleep or staying asleep during scheduled sleeping hours in people who work at night or on rotating shifts). Modafinil is also used along with breathing devices or other treatments to prevent excessive sleepiness caused by obstructive sleep apnea/hypopnea syndrome (OSAHS; a sleep disorder in which the patient briefly stops breathing or breathes shallowly many times during sleep and therefore doesn't get enough restful sleep). Modafinil is in a class of medications called wakefulness promoting agents. It works by changing the amounts of certain natural substances in the area of the brain that controls sleep and wakefulness.

Modafinil comes as a tablet to take by mouth. It is usually taken once a day with or without food. If you are taking modafinil to treat narcolepsy or OSAHS, you will probably take it in the morning. If you are taking modafinil to treat shift work sleep disorder, you will probably take it 1 hour before the beginning of your work shift. Take modafinil at the same time every day. Do not change the time of day that you take modafinil without talking to your doctor. Talk to your doctor if your work shift does not begin at the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take modafinil exactly as directed.

Modafinil may be habit-forming. Do not take a larger dose, take it more often, or take it for a longer period of time than prescribed by your doctor.

Modafinil may decrease your sleepiness, but it will not cure your sleep disorder. Continue to take modafinil even if you feel well-rested. Do not stop taking modafinil without talking to your doctor.

Modafinil should not be used in place of getting enough sleep. Follow your doctor's advice about good sleep habits. Continue to use any breathing devices or other treatments that your doctor has prescribed to treat your condition, especially if you have OSAHS.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking modafinil,

  • tell your doctor and pharmacist if you are allergic to modafinil, armodafinil (Nuvigil), or any other medications.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin); certain antidepressants such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); certain antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral); cyclosporine (Neoral, Sandimmune); diazepam (Valium); certain medications for seizures such as carbamazepine (Tegretol), phenobarbital, and phenytoin (Dilantin); monoamine oxidase (MAO) inhibitors, including isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); propranolol (Inderal); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft); rifampin (Rifadin, Rimactane); and triazolam (Halcion). Many other medications may also interact with modafinil, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you drink or have ever drunk large amounts of alcohol, use or have ever used street drugs, or have overused prescription medications, especially stimulants. Also tell your doctor if you have ever had chest pain, an irregular heartbeat, or other heart problems after taking a stimulant, and if you have or have ever had high blood pressure; a heart attack; chest pain; a mental illness such as depression, mania (frenzied, abnormally excited mood), or psychosis (difficulty thinking clearly, communicating, understanding reality, and behaving appropriately); or heart, liver, or kidney disease.

  • you should know that modafinil may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, implants, injections, and intrauterine devices). Use another form of birth control while taking modafinil and for 1 month after you stop taking it. Talk to your doctor about types of birth control that will work for you during and after your treatment with modafinil.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking modafinil, call your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking modafinil.

  • you should know that modafinil may affect your judgment or thinking and may not completely relieve the sleepiness caused by your disorder. Do not drive a car or operate machinery until you know how this medication affects you. If you avoided driving and other dangerous activities because of your sleep disorder, do not start performing these activities again without talking to your doctor even if you feel more alert.

  • be aware that you should avoid drinking alcohol while taking modafinil.

Talk to your doctor about eating grapefruit or drinking grapefruit juice while you are taking this medication.

You should skip the missed dose. Wait until the next time you are supposed to take modafinil, and then take your normal dose. If you take modafinil too late in your waking day, you may find it harder to go to sleep. Do not take a double dose to make up for a missed one.

  • Modafinil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • headache

    • dizziness

    • difficulty falling asleep or staying asleep

    • drowsiness

    • nausea

    • diarrhea

    • constipation

    • gas

    • heartburn

    • loss of appetite

    • unusual tastes

    • dry mouth

    • excessive thirst

    • nosebleed

    • flushing

    • sweating

    • tight muscles or difficulty moving

    • back pain

    • confusion

    • uncontrollable shaking of a part of your body

    • burning, tingling, or numbness of the skin

    • difficulty seeing or eye pain

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • rash

    • blisters

    • peeling skin

    • mouth sores

    • hives

    • itching

    • hoarseness

    • difficulty breathing or swallowing

    • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

    • chest pain

    • fast, pounding, or irregular heartbeat

    • frenzied, abnormally excited mood

    • hallucinating (seeing things or hearing voices that do not exist)

    • anxiety

    • depression

    • thinking about killing or harming yourself

  • Modafinil may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Store modafinil in a safe place so that no one else can take it accidentally or on purpose. Keep track of how many tablets are left so you will know if any are missing.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • difficulty falling asleep or staying asleep

  • agitation

  • restlessness

  • confusion

  • hallucinations (seeing things or hearing voices that do not exist)

  • nervousness

  • uncontrollable shaking of a part of the body

  • fast, slow, or pounding heartbeat

  • chest pain

  • nausea

  • diarrhea

Keep all appointments with your doctor.

Do not let anyone else take your medication. Selling or giving away modafinil is against the law. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Montelukast Montelukast The metabolism of Montelukast can be decreased when combined with Armodafinil.
Leflunomide Leflunomide The metabolism of Leflunomide can be decreased when combined with Modafinil.
Nevirapine Nevirapine The metabolism of Nevirapine can be increased when combined with Armodafinil.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be increased when combined with Modafinil.
Aminophylline Aminophylline The metabolism of Aminophylline can be increased when combined with Modafinil.
Anagrelide Anagrelide The metabolism of Anagrelide can be increased when combined with Modafinil.
Candesartan Candesartan The metabolism of Candesartan can be decreased when combined with Modafinil.
Cilostazol Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Modafinil.
Clopidogrel Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Modafinil.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Erythromycin can be increased when combined with Modafinil.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The metabolism of Conjugated estrogens can be increased when combined with Armodafinil.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be increased when combined with Modafinil.
Ranitidine Ranitidine The metabolism of Ranitidine can be increased when combined with Modafinil.
Tacrolimus Tacrolimus The metabolism of Tacrolimus can be increased when combined with Modafinil.
Tizanidine Tizanidine The metabolism of Tizanidine can be increased when combined with Modafinil.
Triamcinolone Triamcinolone The metabolism of Triamcinolone can be increased when combined with Modafinil.
Zolmitriptan Zolmitriptan The metabolism of Zolmitriptan can be increased when combined with Modafinil.
Hydromorphone Injection Hydromorphone Injection The metabolism of Hydromorphone can be decreased when combined with Armodafinil.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be increased when combined with Modafinil.
Metoclopramide Injection Metoclopramide Injection The metabolism of Metoclopramide can be increased when combined with Modafinil.
Metronidazole Injection Metronidazole Injection The metabolism of Metronidazole can be increased when combined with Modafinil.
Zidovudine Injection Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Armodafinil.
Altretamine Altretamine The risk or severity of hypertension can be increased when Amphetamine is combined with Modafinil.
Cyclosporine Cyclosporine The serum concentration of Cyclosporine can be decreased when it is combined with Armodafinil.
Ondansetron Ondansetron The metabolism of Ondansetron can be increased when combined with Modafinil.
Torsemide Torsemide The metabolism of Torasemide can be decreased when combined with Modafinil.
Olanzapine Olanzapine The metabolism of Olanzapine can be increased when combined with Modafinil.
Alosetron Alosetron The metabolism of Alosetron can be increased when combined with Modafinil.
Dofetilide Dofetilide The metabolism of Dofetilide can be increased when combined with Modafinil.
Meloxicam Meloxicam The metabolism of Meloxicam can be decreased when combined with Modafinil.
Pantoprazole Pantoprazole The metabolism of Pantoprazole can be decreased when combined with Modafinil.
Zaleplon Zaleplon The metabolism of Zaleplon can be increased when combined with Modafinil.
Trimipramine Trimipramine The metabolism of Trimipramine can be decreased when combined with Modafinil.
Tenofovir Tenofovir The metabolism of Tenofovir can be increased when combined with Modafinil.
Sirolimus Sirolimus The metabolism of Sirolimus can be increased when combined with Modafinil.
Dutasteride Dutasteride The metabolism of Dutasteride can be increased when combined with Modafinil.
Eplerenone Eplerenone The metabolism of Eplerenone can be increased when combined with Modafinil.
Escitalopram Escitalopram The metabolism of Escitalopram can be decreased when combined with Modafinil.
Zonisamide Zonisamide The metabolism of Zonisamide can be decreased when combined with Modafinil.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be increased when combined with Modafinil.
Atazanavir Atazanavir The metabolism of Modafinil can be decreased when combined with Atazanavir.
Eletriptan Eletriptan The metabolism of Eletriptan can be decreased when combined with Modafinil.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be increased when combined with Modafinil.
Vardenafil Vardenafil The metabolism of Vardenafil can be increased when combined with Modafinil.
Aprepitant Aprepitant The metabolism of Aprepitant can be increased when combined with Modafinil.
Tadalafil Tadalafil The metabolism of Tadalafil can be increased when combined with Modafinil.
Frovatriptan Frovatriptan The metabolism of Frovatriptan can be increased when combined with Modafinil.
Progesterone Progesterone The metabolism of Progesterone can be decreased when combined with Modafinil.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be increased when combined with Modafinil.
Duloxetine Duloxetine The metabolism of Duloxetine can be increased when combined with Modafinil.
Norethindrone Norethindrone The metabolism of Norethisterone can be increased when combined with Modafinil.
Bosentan Bosentan The metabolism of Bosentan can be decreased when combined with Armodafinil.
Cinacalcet Cinacalcet The metabolism of Cinacalcet can be increased when combined with Modafinil.
Erlotinib Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Modafinil.
Eszopiclone Eszopiclone The serum concentration of Eszopiclone can be decreased when it is combined with Modafinil.
Voriconazole Voriconazole The metabolism of Voriconazole can be decreased when combined with Modafinil.
Dextroamphetamine Dextroamphetamine The risk or severity of hypertension can be increased when Amphetamine is combined with Modafinil.
Entecavir Entecavir The metabolism of Entecavir can be increased when combined with Modafinil.
Ramelteon Ramelteon The metabolism of Ramelteon can be decreased when combined with Modafinil.
Fentanyl Fentanyl The metabolism of Fentanyl can be increased when combined with Modafinil.
Ranolazine Ranolazine The metabolism of Ranolazine can be increased when combined with Modafinil.
Rasagiline Rasagiline The metabolism of Rasagiline can be increased when combined with Modafinil.
Imatinib Imatinib The metabolism of Imatinib can be decreased when combined with Modafinil.
Gefitinib Gefitinib The metabolism of Gefitinib can be increased when combined with Modafinil.
Paliperidone Paliperidone The metabolism of Paliperidone can be increased when combined with Modafinil.
Bortezomib Bortezomib The metabolism of Bortezomib can be increased when combined with Armodafinil.
Primaquine Primaquine The metabolism of Primaquine can be increased when combined with Modafinil.
Pemetrexed Injection Pemetrexed Injection The metabolism of Pemetrexed can be increased when combined with Modafinil.
Lisdexamfetamine Lisdexamfetamine The risk or severity of hypertension can be increased when Lisdexamfetamine is combined with Modafinil.
Retapamulin Retapamulin The metabolism of Retapamulin can be increased when combined with Modafinil.
Sorafenib Sorafenib The metabolism of Sorafenib can be increased when combined with Modafinil.
Sunitinib Sunitinib The metabolism of Sunitinib can be increased when combined with Modafinil.
Dronabinol Dronabinol The metabolism of Dronabinol can be decreased when combined with Armodafinil.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Modafinil.
Dasatinib Dasatinib The metabolism of Dasatinib can be increased when combined with Modafinil.
Mexiletine Mexiletine The metabolism of Mexiletine can be increased when combined with Armodafinil.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be increased when combined with Modafinil.
Nilotinib Nilotinib The metabolism of Nilotinib can be increased when combined with Modafinil.
Bexarotene Bexarotene The metabolism of Bexarotene can be decreased when combined with Armodafinil.
Etravirine Etravirine The metabolism of Etravirine can be decreased when combined with Modafinil.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Modafinil.
Tretinoin Tretinoin The metabolism of Tretinoin can be increased when combined with Modafinil.
Bendamustine Injection Bendamustine Injection The metabolism of Bendamustine can be increased when combined with Modafinil.
Flecainide Flecainide The metabolism of Flecainide can be increased when combined with Modafinil.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be increased when combined with Modafinil.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be increased when combined with Modafinil.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Modafinil.
Rufinamide Rufinamide The metabolism of Rufinamide can be increased when combined with Modafinil.
Midazolam Midazolam The metabolism of Midazolam can be increased when combined with Modafinil.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be increased when combined with Modafinil.
Milnacipran Milnacipran The metabolism of Milnacipran can be increased when combined with Modafinil.
Dexlansoprazole Dexlansoprazole The metabolism of Dexlansoprazole can be decreased when combined with Modafinil.
Betaxolol Betaxolol The metabolism of Betaxolol can be increased when combined with Modafinil.
Iloperidone Iloperidone The metabolism of Iloperidone can be increased when combined with Modafinil.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Modafinil.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Modafinil.
Everolimus Everolimus The metabolism of Everolimus can be increased when combined with Modafinil.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Tolvaptan can be increased when combined with Modafinil.
Dronedarone Dronedarone The metabolism of Dronedarone can be increased when combined with Modafinil.
Saxagliptin Saxagliptin The metabolism of Saxagliptin can be increased when combined with Modafinil.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be increased when combined with Modafinil.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Modafinil.
Pazopanib Pazopanib The metabolism of Pazopanib can be increased when combined with Modafinil.
Asenapine Asenapine The metabolism of Asenapine can be increased when combined with Modafinil.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Modafinil.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Modafinil.
Ulipristal Ulipristal The metabolism of Ulipristal can be increased when combined with Modafinil.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Modafinil.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be increased when combined with Modafinil.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be increased when combined with Armodafinil.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Modafinil.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be increased when combined with Modafinil.
Roflumilast Roflumilast The metabolism of Roflumilast can be increased when combined with Modafinil.
Linagliptin Linagliptin The metabolism of Linagliptin can be increased when combined with Modafinil.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Modafinil.
Rivaroxaban Rivaroxaban The metabolism of Rivaroxaban can be increased when combined with Modafinil.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be increased when combined with Modafinil.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be increased when combined with Modafinil.
Vandetanib Vandetanib The metabolism of Vandetanib can be increased when combined with Modafinil.
Clobazam Clobazam The metabolism of Clobazam can be decreased when combined with Modafinil.
Vemurafenib Vemurafenib The metabolism of Vemurafenib can be increased when combined with Modafinil.
Vismodegib Vismodegib The metabolism of Vismodegib can be decreased when combined with Modafinil.
Ivacaftor Ivacaftor The metabolism of Ivacaftor can be increased when combined with Modafinil.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Modafinil.
Crizotinib Crizotinib The metabolism of Crizotinib can be increased when combined with Modafinil.
Cabergoline Cabergoline The metabolism of Cabergoline can be increased when combined with Modafinil.
Ambrisentan Ambrisentan The metabolism of Ambrisentan can be increased when combined with Modafinil.
Enzalutamide Enzalutamide The metabolism of Enzalutamide can be increased when combined with Modafinil.
Regorafenib Regorafenib The metabolism of Regorafenib can be increased when combined with Modafinil.
Bosutinib Bosutinib The metabolism of Bosutinib can be increased when combined with Modafinil.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Modafinil.
Ponatinib Ponatinib The metabolism of Ponatinib can be increased when combined with Modafinil.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be increased when combined with Modafinil.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be increased when combined with Modafinil.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Modafinil.
Dabrafenib Dabrafenib The metabolism of Dabrafenib can be increased when combined with Modafinil.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Modafinil.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Modafinil.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Modafinil.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Modafinil.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be increased when combined with Modafinil.
Lomitapide Lomitapide The metabolism of Lomitapide can be increased when combined with Modafinil.
Ketorolac Injection Ketorolac Injection The metabolism of Ketorolac can be decreased when combined with Modafinil.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be increased when combined with Modafinil.
Apremilast Apremilast The metabolism of Modafinil can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Ceritinib can be increased when combined with Modafinil.
Idelalisib Idelalisib The metabolism of Idelalisib can be increased when combined with Modafinil.
Testosterone Injection Testosterone Injection The metabolism of Testosterone can be decreased when combined with Armodafinil.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be increased when combined with Modafinil.
Hydrocodone Hydrocodone The metabolism of Hydrocodone can be decreased when combined with Modafinil.
Suvorexant Suvorexant The metabolism of Suvorexant can be increased when combined with Modafinil.
Olaparib Olaparib The metabolism of Olaparib can be increased when combined with Modafinil.
Methamphetamine Methamphetamine The risk or severity of hypertension can be increased when Metamfetamine is combined with Modafinil.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be increased when combined with Modafinil.
Pirfenidone Pirfenidone The metabolism of Pirfenidone can be increased when combined with Modafinil.
Nintedanib Nintedanib The metabolism of Nintedanib can be increased when combined with Modafinil.
Risperidone Injection Risperidone Injection The metabolism of Risperidone can be increased when combined with Modafinil.
Palbociclib Palbociclib The metabolism of Palbociclib can be increased when combined with Modafinil.
Panobinostat Panobinostat The metabolism of Panobinostat can be increased when combined with Modafinil.
Haloperidol Injection Haloperidol Injection The metabolism of Haloperidol can be increased when combined with Armodafinil.
Sonidegib Sonidegib The metabolism of Sonidegib can be increased when combined with Modafinil.
Rolapitant Rolapitant The metabolism of Rolapitant can be increased when combined with Modafinil.
Daclatasvir Daclatasvir The metabolism of Daclatasvir can be increased when combined with Modafinil.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be increased when combined with Modafinil.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be increased when combined with Modafinil.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be increased when combined with Modafinil.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Modafinil.
Alectinib Alectinib The metabolism of Alectinib can be increased when combined with Modafinil.
Ixazomib Ixazomib The metabolism of Ixazomib can be increased when combined with Modafinil.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Modafinil.
Dexamethasone Injection Dexamethasone Injection The metabolism of Dexamethasone can be increased when combined with Modafinil.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Modafinil.
Venetoclax Venetoclax The metabolism of Venetoclax can be increased when combined with Modafinil.
Cobicistat Cobicistat The metabolism of Cobicistat can be increased when combined with Modafinil.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Modafinil.
Rucaparib Rucaparib The metabolism of Rucaparib can be increased when combined with Modafinil.
Ribociclib Ribociclib The metabolism of Modafinil can be increased when combined with Ribociclib.
Brigatinib Brigatinib The metabolism of Brigatinib can be increased when combined with Modafinil.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Modafinil.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be increased when combined with Modafinil.
Valbenazine Valbenazine The metabolism of Valbenazine can be increased when combined with Modafinil.
Deflazacort Deflazacort The serum concentration of Deflazacort can be decreased when it is combined with Modafinil.
Midostaurin Midostaurin The metabolism of Midostaurin can be increased when combined with Modafinil.
Neratinib Neratinib The metabolism of Neratinib can be increased when combined with Modafinil.
Enasidenib Enasidenib The metabolism of Enasidenib can be increased when combined with Modafinil.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Modafinil.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be increased when combined with Modafinil.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be increased when combined with Modafinil.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Modafinil.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be increased when combined with Modafinil.
Baricitinib Baricitinib The metabolism of Baricitinib can be increased when combined with Modafinil.
Lofexidine Lofexidine The metabolism of Lofexidine can be increased when combined with Modafinil.
Binimetinib Binimetinib The metabolism of Binimetinib can be increased when combined with Modafinil.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be increased when combined with Modafinil.
Doravirine Doravirine The metabolism of Doravirine can be increased when combined with Modafinil.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be increased when combined with Modafinil.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be increased when combined with Modafinil.
Duvelisib Duvelisib The metabolism of Duvelisib can be increased when combined with Modafinil.
Stiripentol Stiripentol The metabolism of Stiripentol can be increased when combined with Modafinil.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be increased when combined with Modafinil.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Modafinil.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Modafinil.
Prucalopride Prucalopride The metabolism of Prucalopride can be increased when combined with Modafinil.
Siponimod Siponimod The metabolism of Siponimod can be increased when combined with Modafinil.
Acyclovir Ophthalmic Acyclovir Ophthalmic The metabolism of Acyclovir can be increased when combined with Modafinil.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be increased when combined with Modafinil.
Esomeprazole Injection Esomeprazole Injection The metabolism of Esomeprazole can be decreased when combined with Modafinil.
Alpelisib Alpelisib The metabolism of Alpelisib can be increased when combined with Modafinil.
Darolutamide Darolutamide The serum concentration of Darolutamide can be decreased when it is combined with Modafinil.
Triclabendazole Triclabendazole The metabolism of Triclabendazole can be decreased when combined with Modafinil.
Entrectinib Entrectinib The metabolism of Entrectinib can be increased when combined with Modafinil.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be increased when combined with Modafinil.
Istradefylline Istradefylline The metabolism of Istradefylline can be increased when combined with Modafinil.
Pitolisant Pitolisant The serum concentration of Modafinil can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The metabolism of Fedratinib can be decreased when combined with Modafinil.
Lefamulin Lefamulin The metabolism of Lefamulin can be increased when combined with Modafinil.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Modafinil.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be increased when combined with Modafinil.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Modafinil.
Voxelotor Voxelotor The serum concentration of Voxelotor can be decreased when it is combined with Modafinil.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Modafinil.
Lumateperone Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Modafinil.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be decreased when it is combined with Modafinil.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be increased when combined with Modafinil.
Cenobamate Cenobamate The serum concentration of Cenobamate can be decreased when it is combined with Modafinil.
Pemigatinib Pemigatinib The metabolism of Pemigatinib can be increased when combined with Modafinil.
Selumetinib Selumetinib The serum concentration of Selumetinib can be decreased when it is combined with Modafinil.
Rimegepant Rimegepant The metabolism of Rimegepant can be increased when combined with Modafinil.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Modafinil.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be increased when it is combined with Modafinil.
Capmatinib Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Modafinil.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Modafinil.
Lurbinectedin Injection Lurbinectedin Injection The serum concentration of Lurbinectedin can be decreased when it is combined with Modafinil.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Modafinil can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be increased when combined with Modafinil.
Theophylline Theophylline The metabolism of Theophylline can be increased when combined with Modafinil.
Indomethacin Indomethacin The metabolism of Indomethacin can be decreased when combined with Modafinil.
Mefenamic Acid Mefenamic Acid The metabolism of Mefenamic acid can be decreased when combined with Modafinil.
Naproxen Naproxen The metabolism of Naproxen can be decreased when combined with Modafinil.
Trazodone Trazodone The metabolism of Trazodone can be increased when combined with Modafinil.
Phenobarbital Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Modafinil.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be increased when combined with Modafinil.
Primidone Primidone The metabolism of Primidone can be decreased when combined with Modafinil.
Methsuximide Methsuximide The metabolism of Methsuximide can be decreased when combined with Modafinil.
Diethylpropion Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Modafinil.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Modafinil.
Diazepam Diazepam The metabolism of Diazepam can be decreased when combined with Modafinil.
Lorazepam Lorazepam The metabolism of Lorazepam can be increased when combined with Modafinil.
Carmustine Carmustine The metabolism of Carmustine can be increased when combined with Modafinil.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be increased when combined with Modafinil.
Thioridazine Thioridazine The metabolism of Thioridazine can be decreased when combined with Modafinil.
Trifluoperazine Trifluoperazine The metabolism of Trifluoperazine can be increased when combined with Modafinil.
Dapsone Dapsone The metabolism of Dapsone can be increased when combined with Modafinil.
Oxycodone Oxycodone The metabolism of Oxycodone can be increased when combined with Modafinil.
Methadone Methadone The metabolism of Methadone can be decreased when combined with Modafinil.
Oxybutynin Oxybutynin The metabolism of Oxybutynin can be increased when combined with Modafinil.
Maprotiline Maprotiline The metabolism of Maprotiline can be increased when combined with Modafinil.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Modafinil.
Perphenazine Perphenazine The metabolism of Perphenazine can be increased when combined with Modafinil.
Azathioprine Azathioprine The metabolism of Azathioprine can be increased when combined with Modafinil.
Phentermine Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Modafinil.
Hydrocortisone Hydrocortisone The metabolism of Hydrocortisone can be increased when combined with Modafinil.
Doxorubicin Doxorubicin The metabolism of Doxorubicin can be increased when combined with Modafinil.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be increased when combined with Modafinil.
Clonidine Clonidine The metabolism of Clonidine can be increased when combined with Modafinil.
Warfarin Warfarin The metabolism of Warfarin can be increased when combined with Modafinil.
Clonazepam Clonazepam The metabolism of Clonazepam can be increased when combined with Modafinil.
Loperamide Loperamide The metabolism of Loperamide can be decreased when combined with Modafinil.
Promethazine Promethazine The metabolism of Promethazine can be decreased when combined with Modafinil.
Chloroquine Chloroquine The metabolism of Chloroquine can be increased when combined with Modafinil.
Quinine Quinine The metabolism of Quinine can be decreased when combined with Modafinil.
Triamterene Triamterene The metabolism of Triamterene can be increased when combined with Modafinil.
Isosorbide Isosorbide The metabolism of Isosorbide can be increased when combined with Modafinil.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Modafinil.
Desipramine Desipramine The metabolism of Desipramine can be decreased when combined with Modafinil.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Modafinil.
Imipramine Imipramine The metabolism of Imipramine can be decreased when combined with Modafinil.
Quinidine Quinidine The metabolism of Quinidine can be increased when combined with Modafinil.
Disopyramide Disopyramide The metabolism of Disopyramide can be increased when combined with Armodafinil.
Valproic Acid Valproic Acid The metabolism of Valproic acid can be decreased when combined with Armodafinil.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Modafinil.
Chlorpropamide Chlorpropamide The metabolism of Chlorpropamide can be decreased when combined with Modafinil.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Modafinil.
Tolazamide Tolazamide The metabolism of Tolazamide can be decreased when combined with Modafinil.
Dextromethorphan Dextromethorphan The metabolism of Dextromethorphan can be increased when combined with Modafinil.
Cyclobenzaprine Cyclobenzaprine The metabolism of Cyclobenzaprine can be increased when combined with Modafinil.
Chlorpheniramine Chlorpheniramine The metabolism of Chlorpheniramine can be increased when combined with Modafinil.
Brompheniramine Brompheniramine The metabolism of Brompheniramine can be decreased when combined with Modafinil.
Chlorzoxazone Chlorzoxazone The metabolism of Chlorzoxazone can be increased when combined with Armodafinil.
Carisoprodol Carisoprodol The metabolism of Carisoprodol can be decreased when combined with Modafinil.
Disulfiram Disulfiram The metabolism of Disulfiram can be increased when combined with Modafinil.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The serum concentration of Propranolol can be increased when it is combined with Modafinil.
Pseudoephedrine Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Modafinil.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be increased when combined with Modafinil.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be increased when combined with Modafinil.
Cephalexin Cephalexin The metabolism of Cephalexin can be increased when combined with Modafinil.
Dacarbazine Dacarbazine The metabolism of Dacarbazine can be increased when combined with Modafinil.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be increased when combined with Modafinil.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be increased when combined with Modafinil.
Vinblastine Vinblastine The metabolism of Vinblastine can be increased when combined with Modafinil.
Metoprolol Metoprolol The metabolism of Metoprolol can be increased when combined with Modafinil.
Hydroxyzine Hydroxyzine The metabolism of Hydroxyzine can be increased when combined with Armodafinil.
Thiothixene Thiothixene The metabolism of Thiothixene can be increased when combined with Modafinil.
Aspirin Aspirin The metabolism of Acetylsalicylic acid can be decreased when combined with Modafinil.
Alprazolam Alprazolam The metabolism of Alprazolam can be increased when combined with Modafinil.
Triazolam Triazolam The metabolism of Triazolam can be increased when combined with Modafinil.
Trimethoprim Trimethoprim The metabolism of Trimethoprim can be decreased when combined with Armodafinil.
Diltiazem Diltiazem The metabolism of Diltiazem can be increased when combined with Modafinil.
Nifedipine Nifedipine The metabolism of Nifedipine can be increased when combined with Modafinil.
Timolol Timolol The metabolism of Timolol can be decreased when combined with Modafinil.
Verapamil Verapamil The metabolism of Verapamil can be decreased when combined with Armodafinil.
Piroxicam Piroxicam The metabolism of Piroxicam can be decreased when combined with Modafinil.
Etoposide Etoposide The metabolism of Etoposide can be increased when combined with Modafinil.
Glyburide Glyburide The metabolism of Glyburide can be decreased when combined with Modafinil.
Glipizide Glipizide The metabolism of Glipizide can be decreased when combined with Modafinil.
Pentoxifylline Pentoxifylline The metabolism of Pentoxifylline can be increased when combined with Modafinil.
Pentamidine Injection Pentamidine Injection The metabolism of Pentamidine can be increased when combined with Modafinil.
Labetalol Labetalol The metabolism of Labetalol can be decreased when combined with Armodafinil.
Guanabenz Guanabenz The metabolism of Guanabenz can be increased when combined with Modafinil.
Pimozide Pimozide The metabolism of Pimozide can be increased when combined with Modafinil.
Flurbiprofen Flurbiprofen The metabolism of Flurbiprofen can be decreased when combined with Modafinil.
Amiodarone Amiodarone The metabolism of Amiodarone can be increased when combined with Modafinil.
Buspirone Buspirone The metabolism of Buspirone can be increased when combined with Modafinil.
Lovastatin Lovastatin The metabolism of Lovastatin can be increased when combined with Modafinil.
Diclofenac Diclofenac The metabolism of Diclofenac can be increased when combined with Modafinil.
Fluoxetine Fluoxetine The metabolism of Fluoxetine can be decreased when combined with Modafinil.
Clozapine Clozapine The metabolism of Clozapine can be increased when combined with Modafinil.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Modafinil.
Clarithromycin Clarithromycin The metabolism of Clarithromycin can be increased when combined with Modafinil.
Etodolac Etodolac The metabolism of Etodolac can be decreased when combined with Modafinil.
Felodipine Felodipine The metabolism of Felodipine can be increased when combined with Modafinil.
Nabumetone Nabumetone The metabolism of Nabumetone can be decreased when combined with Modafinil.
Simvastatin Simvastatin The metabolism of Simvastatin can be increased when combined with Modafinil.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be increased when combined with Modafinil.
Zolpidem Zolpidem The metabolism of Zolpidem can be decreased when combined with Armodafinil.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Modafinil.
Omeprazole Omeprazole The metabolism of Omeprazole can be decreased when combined with Modafinil.
Cisapride Cisapride The metabolism of Cisapride can be increased when combined with Modafinil.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be increased when combined with Modafinil.
Venlafaxine Venlafaxine The metabolism of Venlafaxine can be decreased when combined with Armodafinil.
Famciclovir Famciclovir The metabolism of Famciclovir can be increased when combined with Modafinil.
Fluvoxamine Fluvoxamine The metabolism of Fluvoxamine can be increased when combined with Armodafinil.
Losartan Losartan The metabolism of Losartan can be decreased when combined with Armodafinil.
Tramadol Tramadol The metabolism of Tramadol can be increased when combined with Armodafinil.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be increased when combined with Modafinil.
Lansoprazole Lansoprazole The metabolism of Lansoprazole can be decreased when combined with Modafinil.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Modafinil.
Bupropion Bupropion The serum concentration of Bupropion can be increased when it is combined with Modafinil.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be increased when combined with Modafinil.
Saquinavir Saquinavir The metabolism of Saquinavir can be increased when combined with Modafinil.
Nisoldipine Nisoldipine The metabolism of Nisoldipine can be increased when combined with Modafinil.
Riluzole Riluzole The metabolism of Riluzole can be increased when combined with Modafinil.
Glimepiride Glimepiride The metabolism of Glimepiride can be decreased when combined with Modafinil.
Indinavir Indinavir The metabolism of Indinavir can be increased when combined with Modafinil.
Ritonavir Ritonavir The metabolism of Ritonavir can be increased when combined with Armodafinil.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be increased when combined with Modafinil.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Modafinil.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Modafinil.
Mirtazapine Mirtazapine The metabolism of Mirtazapine can be increased when combined with Armodafinil.
Zileuton Zileuton The metabolism of Zileuton can be increased when combined with Modafinil.
Valsartan Valsartan The metabolism of Valsartan can be decreased when combined with Modafinil.
Donepezil Donepezil The metabolism of Donepezil can be decreased when combined with Modafinil.
Azithromycin Azithromycin The metabolism of Azithromycin can be increased when combined with Modafinil.
Carvedilol Carvedilol The metabolism of Carvedilol can be increased when combined with Modafinil.
Flutamide Flutamide The metabolism of Flutamide can be increased when combined with Modafinil.
Selegiline Selegiline The metabolism of Selegiline can be increased when combined with Modafinil.
Bicalutamide Bicalutamide The metabolism of Bicalutamide can be increased when combined with Modafinil.
Sertraline Sertraline The metabolism of Sertraline can be decreased when combined with Modafinil.
Propafenone Propafenone The metabolism of Propafenone can be increased when combined with Modafinil.
Irbesartan Irbesartan The metabolism of Irbesartan can be decreased when combined with Modafinil.
Ropinirole Ropinirole The metabolism of Ropinirole can be increased when combined with Modafinil.
Finasteride Finasteride The metabolism of Finasteride can be increased when combined with Modafinil.
Quetiapine Quetiapine The metabolism of Quetiapine can be increased when combined with Modafinil.
Paroxetine Paroxetine The metabolism of Paroxetine can be decreased when combined with Armodafinil.
Citalopram Citalopram The serum concentration of Citalopram can be increased when it is combined with Armodafinil.
Capecitabine Capecitabine The metabolism of Capecitabine can be increased when combined with Modafinil.
Efavirenz Efavirenz The metabolism of Efavirenz can be increased when combined with Modafinil.
Sildenafil Sildenafil The metabolism of Sildenafil can be increased when combined with Modafinil.
Celecoxib Celecoxib The metabolism of Celecoxib can be decreased when combined with Armodafinil.
Rosiglitazone Rosiglitazone The metabolism of Rosiglitazone can be decreased when combined with Armodafinil.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Modafinil.
Thalidomide Thalidomide The metabolism of Thalidomide can be decreased when combined with Modafinil.
Nateglinide Nateglinide The metabolism of Nateglinide can be increased when combined with Modafinil.
Rabeprazole Rabeprazole The metabolism of Rabeprazole can be decreased when combined with Modafinil.
Terbinafine Terbinafine The metabolism of Terbinafine can be increased when combined with Modafinil.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists