Palonosetron Injection

Generic name: Pronounced as (pal" oh noe' se tron)
Brand names
  • Aloxi®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 01/15/2015

Palonosetron injection is used to prevent nausea and vomiting that may occur within 24 hours after receiving cancer chemotherapy or surgery. It is also used to prevent delayed nausea and vomiting that may occur several days after receiving certain chemotherapy medications. Palonosetron injection is in a class of medications called 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting.

Palonosetron injection comes as a solution (liquid) to be injected intravenously (into a vein) by a healthcare provider in a hospital or clinic. When palonosetron is used to prevent nausea and vomiting caused by chemotherapy, it is usually given as a single dose about 30 minutes before the start of chemotherapy. If you are receiving more than one course of chemotherapy, you may receive a dose of palonosetron before each treatment cycle. When palonosetron is used to prevent nausea and vomiting caused by surgery, it is usually given as a single dose just before the surgery.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before receiving palonosetron injection,

  • tell your doctor and pharmacist if you are allergic to palonosetron, alosetron (Lotronex), dolasetron (Anzemet), granisetron (Kytril, Sancuso), ondansetron (Zofran), or any other medications, or any of the ingredients in palonosetron injection. Ask your pharmacist or check the manufacturer's patient information for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: fentanyl (Abstral, Actiq, Duragesic, Fentora, Lazanda, Onsolis, Subsys), lithium (Lithobid); medications to treat migraines such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); methylene blue; mirtazapine (Remeron); monoamine oxidase (MAO) inhibitors including isocarboxazid (Marplan), linezolid (Zyvox), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); and tramadol (Conzip, Ultram, in Ultracet). Your doctor may need to change the doses of your medications or monitor you more carefully for side effects.

  • tell your doctor if you have or have ever had any medical condition.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving palonosetron injection, call your doctor.

Unless your doctor tells you otherwise, continue your normal diet.

  • Palonosetron injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • headache

    • constipation

    • pain, redness, or swelling at the injection site

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • hives

    • rash

    • itching

    • difficulty breathing or swallowing

    • chest pain

    • swelling of the face

    • changes in heart beat or heart rhythm

    • dizziness or lightheadedness

    • fainting

    • fast, slow or irregular heartbeat

    • agitation

    • confusion

    • nausea, vomiting, and diarrhea

    • loss of coordination

    • stiff or twitching muscles

    • seizures

    • coma (loss of consciousness)

  • Palonosetron injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • seizures

  • fainting

  • difficulty breathing

  • pale or blue-colored skin

Keep all appointments with your doctor.

Ask your doctor any questions you have about your medication.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Delavirdine Delavirdine The metabolism of Palonosetron can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Palonosetron can be decreased when combined with Nevirapine.
Dolasetron Dolasetron The risk or severity of adverse effects can be increased when Palonosetron is combined with Dolasetron.
Cilostazol Cilostazol Palonosetron may decrease the excretion rate of Cilostazol which could result in a higher serum level.
Diphenoxylate Diphenoxylate The risk or severity of adverse effects can be increased when Palonosetron is combined with Diphenoxylate.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Fenofibrate Fenofibrate Palonosetron may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Guanfacine Guanfacine The risk or severity of adverse effects can be increased when Palonosetron is combined with Guanfacine.
Magnesium Hydroxide Magnesium Hydroxide Palonosetron may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Mycophenolate Mycophenolate Palonosetron may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Naratriptan Naratriptan The risk or severity of adverse effects can be increased when Palonosetron is combined with Naratriptan.
Olsalazine Olsalazine Olsalazine may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Paregoric Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Palonosetron.
Penbutolol Penbutolol The metabolism of Palonosetron can be decreased when combined with Acebutolol.
Pentazocine Pentazocine The risk or severity of adverse effects can be increased when Palonosetron is combined with Pentazocine.
Potassium Potassium Potassium may increase the excretion rate of Palonosetron which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone Palonosetron may decrease the excretion rate of Prednisone which could result in a higher serum level.
Ranitidine Ranitidine The metabolism of Ranitidine can be decreased when combined with Palonosetron.
Reserpine Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Palonosetron.
Rizatriptan Rizatriptan The risk or severity of adverse effects can be increased when Palonosetron is combined with Rizatriptan.
Sumatriptan Sumatriptan The risk or severity of adverse effects can be increased when Palonosetron is combined with Sumatriptan.
Tacrolimus Tacrolimus Tacrolimus may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Tizanidine Tizanidine The risk or severity of adverse effects can be increased when Palonosetron is combined with Tizanidine.
Zolmitriptan Zolmitriptan The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Palonosetron.
Ampicillin Injection Ampicillin Injection Palonosetron may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection Fluconazole may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Palonosetron.
Levofloxacin Injection Levofloxacin Injection Palonosetron may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Meperidine Injection Meperidine Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Meperidine.
Metoclopramide Injection Metoclopramide Injection The risk or severity of sedation can be increased when Metoclopramide is combined with Palonosetron.
Morphine Injection Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Palonosetron.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Palonosetron may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Altretamine Altretamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Palonosetron.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Palonosetron.
Ondansetron Ondansetron The risk or severity of adverse effects can be increased when Palonosetron is combined with Ondansetron.
Granisetron Granisetron The risk or severity of adverse effects can be increased when Palonosetron is combined with Granisetron.
Torsemide Torsemide Torasemide may increase the excretion rate of Palonosetron which could result in a lower serum level and potentially a reduction in efficacy.
Olanzapine Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Palonosetron.
Alosetron Alosetron The risk or severity of adverse effects can be increased when Palonosetron is combined with Alosetron.
Entacapone Entacapone The risk or severity of adverse effects can be increased when Palonosetron is combined with Entacapone.
Hydroxychloroquine Hydroxychloroquine The metabolism of Palonosetron can be decreased when combined with Hydroxychloroquine.
Meloxicam Meloxicam Meloxicam may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Oxcarbazepine Oxcarbazepine The risk or severity of adverse effects can be increased when Palonosetron is combined with Oxcarbazepine.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Temozolomide Temozolomide Palonosetron may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon Zaleplon Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
Anakinra Anakinra The metabolism of Palonosetron can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of adverse effects can be increased when Palonosetron is combined with Desloratadine.
Linezolid Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Palonosetron.
Trimipramine Trimipramine The metabolism of Trimipramine can be decreased when combined with Palonosetron.
Etanercept Injection Etanercept Injection The metabolism of Palonosetron can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Perindopril Perindopril Palonosetron may decrease the excretion rate of Perindopril which could result in a higher serum level.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Eplerenone Eplerenone Eplerenone may increase the excretion rate of Palonosetron which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram Escitalopram The risk or severity of serotonin syndrome can be increased when Palonosetron is combined with Escitalopram.
Zonisamide Zonisamide Palonosetron may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Adalimumab Injection Adalimumab Injection The metabolism of Palonosetron can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The risk or severity of adverse effects can be increased when Palonosetron is combined with Aripiprazole.
Atomoxetine Atomoxetine The risk or severity of adverse effects can be increased when Atomoxetine is combined with Palonosetron.
Dexmethylphenidate Dexmethylphenidate The risk or severity of adverse effects can be increased when Palonosetron is combined with Dexmethylphenidate.
Atazanavir Atazanavir Atazanavir may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Almotriptan Almotriptan The risk or severity of adverse effects can be increased when Palonosetron is combined with Almotriptan.
Eletriptan Eletriptan The risk or severity of adverse effects can be increased when Eletriptan is combined with Palonosetron.
Mefloquine Mefloquine The metabolism of Palonosetron can be decreased when combined with Mefloquine.
Emtricitabine Emtricitabine Palonosetron may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine Memantine Palonosetron may decrease the excretion rate of Memantine which could result in a higher serum level.
Tegaserod Tegaserod The metabolism of Tegaserod can be decreased when combined with Palonosetron.
Tadalafil Tadalafil Palonosetron may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Frovatriptan Frovatriptan The risk or severity of adverse effects can be increased when Palonosetron is combined with Frovatriptan.
Progesterone Progesterone The metabolism of Progesterone can be decreased when combined with Palonosetron.
Apomorphine Injection Apomorphine Injection The risk or severity of hypotension can be increased when Palonosetron is combined with Apomorphine.
Infliximab Injection Infliximab Injection The metabolism of Palonosetron can be increased when combined with Infliximab.
Protriptyline Protriptyline The risk or severity of adverse effects can be increased when Protriptyline is combined with Palonosetron.
Duloxetine Duloxetine The metabolism of Duloxetine can be decreased when combined with Palonosetron.
Tinidazole Tinidazole Palonosetron may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Trospium Trospium Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Cefditoren Cefditoren Palonosetron may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cinacalcet Cinacalcet The metabolism of Palonosetron can be decreased when combined with Cinacalcet.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Palonosetron.
Eszopiclone Eszopiclone The risk or severity of CNS depression can be increased when Palonosetron is combined with Eszopiclone.
Ganciclovir Ganciclovir Palonosetron may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Ribavirin Ribavirin Palonosetron may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Solifenacin Solifenacin Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Valganciclovir Valganciclovir Palonosetron may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Adefovir Adefovir Adefovir may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Palonosetron.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Palonosetron can be decreased when combined with Peginterferon alfa-2b.
Sodium Oxybate Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Palonosetron.
Isocarboxazid Isocarboxazid The risk or severity of adverse effects can be increased when Palonosetron is combined with Isocarboxazid.
Ramelteon Ramelteon The risk or severity of adverse effects can be increased when Palonosetron is combined with Ramelteon.
Darifenacin Darifenacin The metabolism of Darifenacin can be decreased when combined with Palonosetron.
Fentanyl Fentanyl The risk or severity of adverse effects can be increased when Palonosetron is combined with Fentanyl.
Pregabalin Pregabalin The therapeutic efficacy of Palonosetron can be increased when used in combination with Pregabalin.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Palonosetron.
Felbamate Felbamate The risk or severity of adverse effects can be increased when Palonosetron is combined with Felbamate.
Ranolazine Ranolazine The serum concentration of Palonosetron can be increased when it is combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Palonosetron can be increased when combined with Abatacept.
Rasagiline Rasagiline The risk or severity of adverse effects can be increased when Palonosetron is combined with Rasagiline.
Imatinib Imatinib The metabolism of Palonosetron can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin Palonosetron may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Varenicline Varenicline Palonosetron may decrease the excretion rate of Varenicline which could result in a higher serum level.
Gefitinib Gefitinib The metabolism of Palonosetron can be decreased when combined with Gefitinib.
Albuterol Albuterol Palonosetron may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone Paliperidone The risk or severity of adverse effects can be increased when Palonosetron is combined with Paliperidone.
Bortezomib Bortezomib The metabolism of Palonosetron can be decreased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection Palonosetron may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Lubiprostone Lubiprostone Palonosetron may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Primaquine Primaquine The metabolism of Palonosetron can be decreased when combined with Primaquine.
Pemetrexed Injection Pemetrexed Injection Palonosetron may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dimenhydrinate Dimenhydrinate The risk or severity of adverse effects can be increased when Palonosetron is combined with Dimenhydrinate.
Lisdexamfetamine Lisdexamfetamine The risk or severity of serotonin syndrome can be increased when Palonosetron is combined with Lisdexamfetamine.
Nabilone Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Palonosetron.
Sorafenib Sorafenib The metabolism of Sorafenib can be decreased when combined with Palonosetron.
Sunitinib Sunitinib The risk or severity of QTc prolongation and torsade de pointes can be increased when Sunitinib is combined with Palonosetron.
Dronabinol Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Palonosetron.
Levocetirizine Levocetirizine The risk or severity of adverse effects can be increased when Palonosetron is combined with Levocetirizine.
Pegaptanib Injection Pegaptanib Injection Palonosetron may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Mexiletine Mexiletine The metabolism of Mexiletine can be decreased when combined with Palonosetron.
Azacitidine Injection Azacitidine Injection Palonosetron may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Temsirolimus Temsirolimus The metabolism of Palonosetron can be decreased when combined with Temsirolimus.
Lenalidomide Lenalidomide Palonosetron may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Nilotinib Nilotinib The metabolism of Palonosetron can be decreased when combined with Nilotinib.
Budesonide Budesonide Palonosetron may decrease the excretion rate of Budesonide which could result in a higher serum level.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Palonosetron which could result in a higher serum level.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Palonosetron.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Palonosetron.
Doripenem Injection Doripenem Injection Palonosetron may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection Arsenic Trioxide Injection Palonosetron may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Desvenlafaxine Desvenlafaxine The risk or severity of adverse effects can be increased when Palonosetron is combined with Desvenlafaxine.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Palonosetron.
Flecainide Flecainide The metabolism of Flecainide can be decreased when combined with Palonosetron.
Certolizumab Injection Certolizumab Injection The metabolism of Certolizumab pegol can be increased when combined with Palonosetron.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Methylnaltrexone Injection Methylnaltrexone Injection Palonosetron may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Rufinamide Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Palonosetron.
Midazolam Midazolam The risk or severity of adverse effects can be increased when Palonosetron is combined with Midazolam.
Naltrexone Injection Naltrexone Injection The risk or severity of serotonin syndrome can be increased when Palonosetron is combined with Naltrexone.
Dexrazoxane Injection Dexrazoxane Injection Palonosetron may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
Milnacipran Milnacipran The risk or severity of adverse effects can be increased when Palonosetron is combined with Milnacipran.
Plerixafor Injection Plerixafor Injection Palonosetron may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine Fesoterodine Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Betaxolol Betaxolol The metabolism of Palonosetron can be decreased when combined with Betaxolol.
Iloperidone Iloperidone The risk or severity of adverse effects can be increased when Palonosetron is combined with Iloperidone.
Prasugrel Prasugrel Palonosetron may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Lacosamide Lacosamide The risk or severity of adverse effects can be increased when Palonosetron is combined with Lacosamide.
Everolimus Everolimus The metabolism of Palonosetron can be decreased when combined with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Palonosetron which could result in a lower serum level and potentially a reduction in efficacy.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Palonosetron.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Palonosetron.
Pralatrexate Injection Pralatrexate Injection Palonosetron may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Saxagliptin Saxagliptin Palonosetron may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection Telavancin Injection Palonosetron may decrease the excretion rate of Telavancin which could result in a higher serum level.
Tapentadol Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Palonosetron.
Topotecan Topotecan Palonosetron may decrease the excretion rate of Topotecan which could result in a higher serum level.
Golimumab Injection Golimumab Injection The metabolism of Palonosetron can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Palonosetron can be decreased when combined with Pazopanib.
Asenapine Asenapine The risk or severity of adverse effects can be increased when Palonosetron is combined with Asenapine.
Vigabatrin Vigabatrin The risk or severity of adverse effects can be increased when Palonosetron is combined with Vigabatrin.
Oxymorphone Oxymorphone The risk or severity of adverse effects can be increased when Palonosetron is combined with Oxymorphone.
Tocilizumab Injection Tocilizumab Injection The metabolism of Palonosetron can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine Palonosetron may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Palonosetron.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Lurasidone Lurasidone The risk or severity of adverse effects can be increased when Palonosetron is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection Acetaminophen may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Palonosetron.
Ipilimumab Injection Ipilimumab Injection Palonosetron may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Palonosetron may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Roflumilast Roflumilast Palonosetron may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Rilpivirine Rilpivirine The metabolism of Palonosetron can be decreased when combined with Rilpivirine.
Abiraterone Abiraterone The metabolism of Palonosetron can be decreased when combined with Abiraterone.
Rivaroxaban Rivaroxaban Palonosetron may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ruxolitinib Ruxolitinib Palonosetron may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Clobazam Clobazam The metabolism of Palonosetron can be decreased when combined with Clobazam.
Vemurafenib Vemurafenib The metabolism of Palonosetron can be decreased when combined with Vemurafenib.
Deferiprone Deferiprone Palonosetron may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Cabergoline Cabergoline The risk or severity of adverse effects can be increased when Cabergoline is combined with Palonosetron.
Naloxone Injection Naloxone Injection Palonosetron may decrease the excretion rate of Naloxone which could result in a higher serum level.
Fondaparinux Injection Fondaparinux Injection Palonosetron may decrease the excretion rate of Fondaparinux which could result in a higher serum level.
Ezogabine Ezogabine The risk or severity of adverse effects can be increased when Palonosetron is combined with Tiagabine.
Enzalutamide Enzalutamide Palonosetron may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron Mirabegron The metabolism of Mirabegron can be decreased when combined with Palonosetron.
Teduglutide Injection Teduglutide Injection Palonosetron may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Alogliptin Alogliptin Palonosetron may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Palonosetron.
Pomalidomide Pomalidomide The risk or severity of adverse effects can be increased when Palonosetron is combined with Pomalidomide.
Canagliflozin Canagliflozin Palonosetron may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Palonosetron which could result in a lower serum level and potentially a reduction in efficacy.
Ospemifene Ospemifene The metabolism of Palonosetron can be decreased when combined with Ospemifene.
Trametinib Trametinib Palonosetron may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran The risk or severity of adverse effects can be increased when Palonosetron is combined with Levomilnacipran.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Vortioxetine Vortioxetine The risk or severity of adverse effects can be increased when Palonosetron is combined with Vortioxetine.
Perampanel Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Palonosetron.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Palonosetron.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Sofosbuvir Sofosbuvir Palonosetron may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin Dapagliflozin may increase the excretion rate of Palonosetron which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast Apremilast The metabolism of Apremilast can be increased when combined with Palonosetron.
Droxidopa Droxidopa Palonosetron may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Siltuximab Injection Siltuximab Injection The metabolism of Palonosetron can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The risk or severity of adverse effects can be increased when Palonosetron is combined with Eslicarbazepine.
Testosterone Injection Testosterone Injection Palonosetron may decrease the excretion rate of Testosterone which could result in a higher serum level.
Oritavancin Injection Oritavancin Injection The metabolism of Palonosetron can be decreased when combined with Oritavancin.
Hydrocodone Hydrocodone Hydrocodone may increase the central nervous system depressant (CNS depressant) activities of Palonosetron.
Suvorexant Suvorexant Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Edoxaban Edoxaban Palonosetron may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Methamphetamine Methamphetamine The risk or severity of adverse effects can be increased when Palonosetron is combined with Metamfetamine.
Tasimelteon Tasimelteon The risk or severity of adverse effects can be increased when Palonosetron is combined with Tasimelteon.
Secukinumab Injection Secukinumab Injection The metabolism of Palonosetron can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Risperidone.
Lenvatinib Lenvatinib The metabolism of Palonosetron can be decreased when combined with Lenvatinib.
Naloxegol Naloxegol The metabolism of Palonosetron can be decreased when combined with Naloxegol.
Panobinostat Panobinostat The metabolism of Palonosetron can be decreased when combined with Panobinostat.
Haloperidol Injection Haloperidol Injection The risk or severity of CNS depression can be increased when Haloperidol is combined with Palonosetron.
Amiloride Amiloride Amiloride may increase the excretion rate of Palonosetron which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan Macitentan Palonosetron may decrease the excretion rate of Macitentan which could result in a higher serum level.
Flibanserin Flibanserin The risk or severity of adverse effects can be increased when Palonosetron is combined with Flibanserin.
Rolapitant Rolapitant The metabolism of Palonosetron can be decreased when combined with Rolapitant.
Brexpiprazole Brexpiprazole The risk or severity of adverse effects can be increased when Palonosetron is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Palonosetron.
Cariprazine Cariprazine The risk or severity of adverse effects can be increased when Palonosetron is combined with Cariprazine.
Penicillin G Procaine Injection Penicillin G Procaine Injection Palonosetron may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline Eluxadoline The risk or severity of serotonin syndrome can be increased when Palonosetron is combined with Eluxadoline.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Palonosetron.
Ixazomib Ixazomib Palonosetron may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lesinurad Lesinurad Palonosetron may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Brivaracetam Injection Brivaracetam Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Brivaracetam.
Cobicistat Cobicistat The metabolism of Palonosetron can be decreased when combined with Cobicistat.
Pimavanserin Pimavanserin The risk or severity of adverse effects can be increased when Palonosetron is combined with Pimavanserin.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Diphenhydramine.
Furosemide Injection Furosemide Injection Palonosetron may increase the excretion rate of Furosemide which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib Rucaparib The metabolism of Palonosetron can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection Palonosetron may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Doxepin (Insomnia) Doxepin (Insomnia) Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Deutetrabenazine Deutetrabenazine Palonosetron may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Palonosetron may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Safinamide Safinamide The risk or severity of adverse effects can be increased when Palonosetron is combined with Safinamide.
Naldemedine Naldemedine Palonosetron may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Midostaurin Midostaurin The metabolism of Palonosetron can be decreased when combined with Midostaurin.
Enasidenib Enasidenib The metabolism of Palonosetron can be decreased when combined with Enasidenib.
Benznidazole Benznidazole Palonosetron may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin Palonosetron may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Letermovir Letermovir The metabolism of Letermovir can be decreased when combined with Palonosetron.
Tetrabenazine Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Palonosetron.
Ertugliflozin Ertugliflozin Ertugliflozin may increase the excretion rate of Palonosetron which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection Buprenorphine Injection Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide Apalutamide Palonosetron may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Baricitinib Baricitinib Palonosetron may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine The therapeutic efficacy of Palonosetron can be increased when used in combination with Lofexidine.
Plazomicin Injection Plazomicin Injection Palonosetron may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat Eliglustat The metabolism of Palonosetron can be decreased when combined with Eliglustat.
Encorafenib Encorafenib The metabolism of Encorafenib can be decreased when combined with Palonosetron.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Palonosetron.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Palonosetron.
Cannabidiol Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Palonosetron.
Dacomitinib Dacomitinib The metabolism of Palonosetron can be decreased when combined with Dacomitinib.
Stiripentol Stiripentol The metabolism of Palonosetron can be decreased when combined with Stiripentol.
Gilteritinib Gilteritinib The therapeutic efficacy of Palonosetron can be decreased when used in combination with Gilteritinib.
Rifamycin Rifamycin The metabolism of Palonosetron can be decreased when combined with Rifamycin.
Prucalopride Prucalopride Palonosetron may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Palonosetron can be increased when combined with Emapalumab.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Brexanolone Injection Brexanolone Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Brexanolone.
Solriamfetol Solriamfetol The risk or severity of adverse effects can be increased when Palonosetron is combined with Solriamfetol.
Triclabendazole Triclabendazole The metabolism of Palonosetron can be decreased when combined with Triclabendazole.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Palonosetron.
Pitolisant Pitolisant The serum concentration of Palonosetron can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The metabolism of Palonosetron can be decreased when combined with Fedratinib.
Phenytoin Injection Phenytoin Injection The risk or severity of adverse effects can be increased when Phenytoin is combined with Palonosetron.
Fosphenytoin Injection Fosphenytoin Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Fosphenytoin.
Lumateperone Lumateperone The risk or severity of adverse effects can be increased when Palonosetron is combined with Lumateperone.
Lasmiditan Lasmiditan The risk or severity of serotonin syndrome can be increased when Palonosetron is combined with Lasmiditan.
Cenobamate Cenobamate The serum concentration of Palonosetron can be decreased when it is combined with Cenobamate.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Palonosetron.
Lemborexant Lemborexant The risk or severity of adverse effects can be increased when Palonosetron is combined with Lemborexant.
Fenfluramine Fenfluramine The risk or severity of serotonin syndrome can be increased when Palonosetron is combined with Fenfluramine.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Palonosetron can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Palonosetron which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine Viloxazine The risk or severity of adverse effects can be increased when Palonosetron is combined with Viloxazine.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Theophylline Theophylline The metabolism of Palonosetron can be decreased when combined with Theophylline.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Indomethacin Indomethacin Indomethacin may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid Mefenamic acid may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Naproxen Naproxen Naproxen may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Trazodone Trazodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Palonosetron.
Isotretinoin Isotretinoin Palonosetron may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Hydroxyurea Hydroxyurea The metabolism of Palonosetron can be decreased when combined with Hydroxyurea.
Floxuridine Floxuridine Floxuridine may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Phenobarbital Phenobarbital The risk or severity of adverse effects can be increased when Palonosetron is combined with Phenobarbital.
Metaxalone Metaxalone The risk or severity of adverse effects can be increased when Palonosetron is combined with Metaxalone.
Methotrexate Injection Methotrexate Injection Methotrexate may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Levorphanol Levorphanol The risk or severity of adverse effects can be increased when Palonosetron is combined with Levorphanol.
Primidone Primidone The risk or severity of adverse effects can be increased when Palonosetron is combined with Primidone.
Methsuximide Methsuximide The risk or severity of adverse effects can be increased when Palonosetron is combined with Methsuximide.
Diethylpropion Diethylpropion The risk or severity of adverse effects can be increased when Palonosetron is combined with Diethylpropion.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Palonosetron.
Diazepam Diazepam The risk or severity of adverse effects can be increased when Palonosetron is combined with Diazepam.
Oxazepam Oxazepam The risk or severity of adverse effects can be increased when Palonosetron is combined with Oxazepam.
Flurazepam Flurazepam The risk or severity of adverse effects can be increased when Palonosetron is combined with Flurazepam.
Clorazepate Clorazepate The risk or severity of adverse effects can be increased when Palonosetron is combined with Clorazepic acid.
Lorazepam Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Palonosetron.
Carmustine Carmustine Carmustine may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Amantadine Amantadine The risk or severity of serotonin syndrome can be increased when Palonosetron is combined with Amantadine.
Codeine Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Palonosetron.
Meprobamate Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Palonosetron.
Chlordiazepoxide Chlordiazepoxide The risk or severity of adverse effects can be increased when Palonosetron is combined with Chlordiazepoxide.
Bromocriptine Bromocriptine The risk or severity of adverse effects can be increased when Palonosetron is combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Tranylcypromine can be decreased when combined with Palonosetron.
Phenelzine Phenelzine The risk or severity of adverse effects can be increased when Palonosetron is combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Palonosetron is combined with Procarbazine.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of adverse effects can be increased when Palonosetron is combined with Ergoloid mesylate.
Tetracycline Tetracycline Palonosetron may decrease the excretion rate of Tetracycline which could result in a higher serum level.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Palonosetron.
Prochlorperazine Prochlorperazine The risk or severity of adverse effects can be increased when Palonosetron is combined with Prochlorperazine.
Thioridazine Thioridazine The metabolism of Palonosetron can be decreased when combined with Thioridazine.
Trifluoperazine Trifluoperazine The risk or severity of adverse effects can be increased when Palonosetron is combined with Trifluoperazine.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Sulfadiazine Sulfadiazine Sulfadiazine may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Oxycodone Oxycodone The risk or severity of adverse effects can be increased when Palonosetron is combined with Oxycodone.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Palonosetron.
Oxybutynin Oxybutynin The metabolism of Palonosetron can be decreased when combined with Oxybutynin.
Benztropine Benztropine Benzatropine may increase the central nervous system depressant (CNS depressant) activities of Palonosetron.
Maprotiline Maprotiline Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
Ibuprofen Ibuprofen Ibuprofen may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Trihexyphenidyl Trihexyphenidyl Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine Orphenadrine Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine Perphenazine The metabolism of Palonosetron can be decreased when combined with Perphenazine.
Azathioprine Azathioprine Palonosetron may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Fluphenazine Fluphenazine The risk or severity of adverse effects can be increased when Palonosetron is combined with Fluphenazine.
Phentermine Phentermine The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Palonosetron.
Methylphenidate Methylphenidate Palonosetron may decrease the excretion rate of Methylphenidate which could result in a higher serum level.
Amoxapine Amoxapine The metabolism of Amoxapine can be decreased when combined with Palonosetron.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Doxorubicin Doxorubicin The metabolism of Palonosetron can be decreased when combined with Doxorubicin.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Carbamazepine Carbamazepine Palonosetron may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
Molindone Molindone The risk or severity of adverse effects can be increased when Palonosetron is combined with Molindone.
Methyldopa Methyldopa Palonosetron may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Palonosetron.
Hydralazine Hydralazine Palonosetron may decrease the excretion rate of Hydralazine which could result in a higher serum level.
Cimetidine Cimetidine The metabolism of Cimetidine can be decreased when combined with Palonosetron.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Warfarin Warfarin Palonosetron may decrease the excretion rate of Warfarin which could result in a higher serum level.
Clonazepam Clonazepam The risk or severity of adverse effects can be increased when Palonosetron is combined with Clonazepam.
Loperamide Loperamide The metabolism of Loperamide can be decreased when combined with Palonosetron.
Promethazine Promethazine Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Promethazine.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Palonosetron may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Digoxin Digoxin Palonosetron may decrease the excretion rate of Digoxin which could result in a higher serum level.
Loxapine Loxapine The risk or severity of adverse effects can be increased when Palonosetron is combined with Loxapine.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Palonosetron.
Quinine Quinine The metabolism of Palonosetron can be decreased when combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of adverse effects can be increased when Palonosetron is combined with Ethosuximide.
Triamterene Triamterene Triamterene may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Chlorothiazide Chlorothiazide Chlorothiazide may increase the excretion rate of Palonosetron which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone Chlorthalidone Chlorthalidone may increase the excretion rate of Palonosetron which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone Metolazone Palonosetron may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide Isosorbide may increase the excretion rate of Palonosetron which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital Secobarbital The risk or severity of adverse effects can be increased when Palonosetron is combined with Secobarbital.
Desipramine Desipramine The metabolism of Desipramine can be decreased when combined with Palonosetron.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Palonosetron.
Imipramine Imipramine The metabolism of Imipramine can be decreased when combined with Palonosetron.
Probenecid Probenecid Palonosetron may decrease the excretion rate of Probenecid which could result in a higher serum level.
Quinidine Quinidine The metabolism of Quinidine can be decreased when combined with Palonosetron.
Procainamide Procainamide The metabolism of Procainamide can be decreased when combined with Palonosetron.
Isoniazid Isoniazid The risk or severity of serotonin syndrome can be increased when Palonosetron is combined with Isoniazid.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Disopyramide Disopyramide Disopyramide may increase the central nervous system depressant (CNS depressant) activities of Palonosetron.
Valproic Acid Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Palonosetron.
Tamoxifen Tamoxifen The metabolism of Palonosetron can be decreased when combined with Tamoxifen.
Butabarbital Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Palonosetron.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Methimazole Methimazole The metabolism of Palonosetron can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide Palonosetron may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
Tolbutamide Tolbutamide Palonosetron may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolazamide Tolazamide Palonosetron may decrease the excretion rate of Tolazamide which could result in a higher serum level.
Dextromethorphan Dextromethorphan The risk or severity of adverse effects can be increased when Palonosetron is combined with Dextromethorphan.
Cyclobenzaprine Cyclobenzaprine The risk or severity of CNS depression can be increased when Palonosetron is combined with Cyclobenzaprine.
Niacin Niacin The metabolism of Palonosetron can be decreased when combined with Niacin.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Palonosetron.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Palonosetron.
Cyproheptadine Cyproheptadine The risk or severity of adverse effects can be increased when Palonosetron is combined with Cyproheptadine.
Clemastine Clemastine The metabolism of Palonosetron can be decreased when combined with Clemastine.
Chlorpheniramine Chlorpheniramine The risk or severity of adverse effects can be increased when Palonosetron is combined with Chlorpheniramine.
Brompheniramine Brompheniramine The risk or severity of adverse effects can be increased when Palonosetron is combined with Dexbrompheniramine.
Meclizine Meclizine The risk or severity of adverse effects can be increased when Palonosetron is combined with Meclizine.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Methyclothiazide Methyclothiazide Methyclothiazide may increase the excretion rate of Palonosetron which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Dantrolene Dantrolene The risk or severity of adverse effects can be increased when Palonosetron is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Palonosetron.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Palonosetron.
Methocarbamol Methocarbamol The risk or severity of adverse effects can be increased when Palonosetron is combined with Methocarbamol.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Palonosetron may decrease the excretion rate of Propranolol which could result in a higher serum level.
Pseudoephedrine Pseudoephedrine The risk or severity of serotonin syndrome can be increased when Palonosetron is combined with Pseudoephedrine.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Palonosetron.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Palonosetron which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Phytonadione Phytonadione Palonosetron may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Nadolol Nadolol Palonosetron may decrease the excretion rate of Nadolol which could result in a higher serum level.
Butorphanol Injection Butorphanol Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Butorphanol.
Nalbuphine Injection Nalbuphine Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Nalbuphine.
Allopurinol Allopurinol Palonosetron may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Trimethobenzamide Trimethobenzamide The risk or severity of adverse effects can be increased when Palonosetron is combined with Trimethobenzamide.
Flavoxate Flavoxate Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Colchicine Colchicine Palonosetron may decrease the excretion rate of Colchicine which could result in a higher serum level.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Dacarbazine Dacarbazine Palonosetron may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Acetazolamide Acetazolamide The risk or severity of adverse effects can be increased when Palonosetron is combined with Acetazolamide.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Ketoconazole Ketoconazole The metabolism of Palonosetron can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel The risk or severity of adverse effects can be increased when Palonosetron is combined with Pyrantel.
Vinblastine Vinblastine The metabolism of Palonosetron can be decreased when combined with Vinblastine.
Ethacrynic Acid Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Metoprolol Metoprolol The metabolism of Palonosetron can be decreased when combined with Metoprolol.
Hydroxyzine Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Palonosetron.
Thiothixene Thiothixene The risk or severity of adverse effects can be increased when Palonosetron is combined with Thiothixene.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Salsalate Salsalate Salsalate may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Alprazolam Alprazolam The risk or severity of adverse effects can be increased when Palonosetron is combined with Alprazolam.
Temazepam Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Palonosetron.
Triazolam Triazolam The risk or severity of adverse effects can be increased when Palonosetron is combined with Triazolam.
Dicyclomine Dicyclomine Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine Hyoscyamine Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline Propantheline Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Trimethoprim Trimethoprim Palonosetron may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Diltiazem Diltiazem The metabolism of Palonosetron can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Nifedipine can be decreased when combined with Palonosetron.
Timolol Timolol Timolol may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Verapamil Verapamil The metabolism of Verapamil can be decreased when combined with Palonosetron.
Atenolol Atenolol The metabolism of Palonosetron can be decreased when combined with Atenolol.
Pindolol Pindolol The risk or severity of adverse effects can be increased when Palonosetron is combined with Pindolol.
Cisplatin Injection Cisplatin Injection Palonosetron may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal Diflunisal may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Piroxicam Piroxicam Piroxicam may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Bumetanide Bumetanide Palonosetron may increase the excretion rate of Bumetanide which could result in a lower serum level and potentially a reduction in efficacy.
Glipizide Glipizide Palonosetron may decrease the excretion rate of Glipizide which could result in a higher serum level.
Indapamide Indapamide Palonosetron may increase the excretion rate of Indapamide which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin Amoxicillin Palonosetron may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Palonosetron may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline Pentoxifylline Palonosetron may decrease the excretion rate of Pentoxifylline which could result in a higher serum level.
Pentamidine Injection Pentamidine Injection Pentamidine may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Labetalol Labetalol The metabolism of Palonosetron can be decreased when combined with Labetalol.
Auranofin Auranofin Palonosetron may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Leuprolide may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Gemfibrozil Gemfibrozil Palonosetron may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Pimozide Pimozide The metabolism of Palonosetron can be decreased when combined with Pimozide.
Flurbiprofen Flurbiprofen Flurbiprofen may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Amiodarone Amiodarone The metabolism of Palonosetron can be decreased when combined with Amiodarone.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Buspirone Buspirone The risk or severity of serotonin syndrome can be increased when Palonosetron is combined with Buspirone.
Lovastatin Lovastatin The metabolism of Palonosetron can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin Palonosetron may decrease the excretion rate of Ciprofloxacin which could result in a higher serum level.
Mesalamine Mesalamine Mesalazine may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Diclofenac Diclofenac Diclofenac may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Fluoxetine Fluoxetine The serum concentration of Palonosetron can be increased when it is combined with Fluoxetine.
Clozapine Clozapine The metabolism of Palonosetron can be decreased when combined with Clozapine.
Estazolam Estazolam The risk or severity of adverse effects can be increased when Palonosetron is combined with Estazolam.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Palonosetron.
Didanosine Didanosine Palonosetron may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Palonosetron may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Etodolac Etodolac Etodolac may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Felodipine Felodipine The metabolism of Palonosetron can be decreased when combined with Felodipine.
Fosinopril Fosinopril Palonosetron may decrease the excretion rate of Fosinopril which could result in a higher serum level.
Nabumetone Nabumetone Nabumetone may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Palonosetron.
Lisinopril Lisinopril Palonosetron may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Sotalol Sotalol The metabolism of Sotalol can be decreased when combined with Palonosetron.
Bisoprolol Bisoprolol Palonosetron may decrease the excretion rate of Bisoprolol which could result in a higher serum level.
Zolpidem Zolpidem Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Palonosetron.
Isradipine Isradipine Isradipine may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Omeprazole Omeprazole The metabolism of Palonosetron can be decreased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Cisapride can be decreased when combined with Palonosetron.
Gabapentin Gabapentin The risk or severity of adverse effects can be increased when Palonosetron is combined with Gabapentin.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Palonosetron.
Venlafaxine Venlafaxine The metabolism of Palonosetron can be decreased when combined with Venlafaxine.
Fluvoxamine Fluvoxamine The metabolism of Fluvoxamine can be decreased when combined with Palonosetron.
Nefazodone Nefazodone The risk or severity of adverse effects can be increased when Nefazodone is combined with Palonosetron.
Lamotrigine Lamotrigine Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Tramadol Tramadol The risk or severity of serotonin syndrome can be increased when Palonosetron is combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The metabolism of Palonosetron can be decreased when combined with Vinorelbine.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Lansoprazole Lansoprazole The metabolism of Palonosetron can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection Palonosetron may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Nicardipine Nicardipine The metabolism of Palonosetron can be decreased when combined with Nicardipine.
Bupropion Bupropion The metabolism of Palonosetron can be decreased when combined with Bupropion.
Ticlopidine Ticlopidine The metabolism of Palonosetron can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Palonosetron can be decreased when combined with Saquinavir.
Metformin Metformin Metformin may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Nisoldipine Nisoldipine Palonosetron may decrease the excretion rate of Nisoldipine which could result in a higher serum level.
Lamivudine Lamivudine Palonosetron may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole The risk or severity of adverse effects can be increased when Palonosetron is combined with Riluzole.
Acarbose Acarbose Acarbose may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection Palonosetron may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Ritonavir Ritonavir The serum concentration of Palonosetron can be increased when it is combined with Ritonavir.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Meropenem Injection Meropenem Injection Palonosetron may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Palonosetron.
Fosfomycin Fosfomycin Palonosetron may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine Mirtazapine Palonosetron may increase the serotonergic activities of Mirtazapine.
Topiramate Topiramate The risk or severity of adverse effects can be increased when Topiramate is combined with Palonosetron.
Pramipexole Pramipexole Palonosetron may increase the sedative activities of Pramipexole.
Donepezil Donepezil The risk or severity of adverse effects can be increased when Palonosetron is combined with Donepezil.
Nelfinavir Nelfinavir The metabolism of Palonosetron can be decreased when combined with Nelfinavir.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Palonosetron.
Nilutamide Nilutamide Palonosetron may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Flutamide Flutamide Palonosetron may decrease the excretion rate of Flutamide which could result in a higher serum level.
Selegiline Selegiline The risk or severity of adverse effects can be increased when Palonosetron is combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Palonosetron can be decreased when combined with Bicalutamide.
Sertraline Sertraline The risk or severity of adverse effects can be increased when Palonosetron is combined with Sertraline.
Propafenone Propafenone The metabolism of Palonosetron can be decreased when combined with Propafenone.
Tamsulosin Tamsulosin Palonosetron may decrease the excretion rate of Tamsulosin which could result in a higher serum level.
Ropinirole Ropinirole Palonosetron may increase the sedative activities of Ropinirole.
Quetiapine Quetiapine Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Cetirizine Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Palonosetron.
Paroxetine Paroxetine The metabolism of Palonosetron can be decreased when combined with Paroxetine.
Tolcapone Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Palonosetron.
Citalopram Citalopram The risk or severity of adverse effects can be increased when Palonosetron is combined with Citalopram.
Capecitabine Capecitabine Palonosetron may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Efavirenz Efavirenz The risk or severity of adverse effects can be increased when Palonosetron is combined with Efavirenz.
Abacavir Abacavir Palonosetron may decrease the excretion rate of Abacavir which could result in a higher serum level.
Sildenafil Sildenafil The metabolism of Palonosetron can be decreased when combined with Sildenafil.
Celecoxib Celecoxib The metabolism of Palonosetron can be decreased when combined with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Palonosetron can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Tolterodine.
Thalidomide Thalidomide Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Nateglinide Nateglinide Palonosetron may decrease the excretion rate of Nateglinide which could result in a higher serum level.
Galantamine Galantamine The metabolism of Galantamine can be decreased when combined with Palonosetron.
Levetiracetam Levetiracetam The risk or severity of adverse effects can be increased when Palonosetron is combined with Levetiracetam.
Rabeprazole Rabeprazole Palonosetron may decrease the excretion rate of Rabeprazole which could result in a higher serum level.
Terbinafine Terbinafine The metabolism of Palonosetron can be decreased when combined with Terbinafine.

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