FDA-filed SPL labeling · retrieved through openFDA

Clonidine

Clonidine is a blood pressure–lowering medication used across several products to treat high blood pressure, ADHD in children, and severe cancer pain.

Brand names CatapresKapvayJenlogaNexiclonOnyda +11 more
Drug class ⓘ Central Alpha-2 Adrenergic Agonist
Rx Forms 6 Routes Oral · Transdermal · Epidural · Intravenous
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 132 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveJan 11, 2024
Clinical labels in scope ⓘ132
AvailabilityRx
Earliest approval/marketing year ⓘ1974
FDA-listed product records ⓘ446
Boxed warningNone found in compared labels
How we combine label and product data →
✓No current FDA shortage listed · checked Sep 22, 2026 🚨Recall on record · 3
Other forms & routes:
Transdermal
⭐ Clonidine at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Clonidine is a versatile medication used to treat high blood pressure in adults, ADHD in children ages 6–17, and severe cancer pain when opioids alone aren't enough — each use tied to a specific product or formulation. It works well but requires careful dose management: never stop it abruptly, since that can cause a dangerous rebound rise in blood pressure. Drowsiness is the most common side effect, so follow your prescriber's guidance closely and keep all follow-up appointments.
How we write & review this content — our editorial policy →

📖 Clonidine: Patient Information Guide

A plain-language walkthrough of Clonidine — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for▾

Clonidine is used across several different products and formulations for distinct medical conditions.

  • High blood pressure (hypertension): Clonidine Hydrochloride tablets, Javadin oral solution, Nexiclon XR extended-release tablets, and Catapres-TTS skin patches are all approved to lower blood pressure in adults — alone or alongside other antihypertensive medicines. Lowering blood pressure reduces the risk of stroke and heart attack.
  • ADHD in children and adolescents (ages 6–17): Onyda XR extended-release oral suspension and clonidine hydrochloride extended-release tablets (including Kapvay) are approved to treat ADHD as a standalone therapy or added to stimulant medications.
  • Severe cancer pain: Duraclon and other clonidine injection products are approved — in combination with opioid pain medicines — for severe cancer pain that opioids alone cannot adequately control. This use is specifically for a carefully selected group of cancer patients.
⚙️How it works▾

Clonidine works by stimulating alpha-2 adrenergic receptors in the brainstem — essentially activating a calming switch in the nervous system. This reduces the outflow of nerve signals that would otherwise keep blood vessels tight and the heart rate elevated, resulting in lower blood pressure, lower heart rate, and reduced resistance in blood vessels. For ADHD, the exact mechanism is not known, and clonidine is not a stimulant.

💊How it's taken▾

How clonidine is taken depends entirely on the product and condition being treated. Oral tablets and solutions are generally taken twice daily, often with a larger dose at bedtime. Extended-release forms are taken once or twice daily and must be swallowed whole — never crushed or chewed. Skin patches are applied once a week to a hairless area of skin. Injections for cancer pain are given by a healthcare team via continuous epidural infusion.

  • Clonidine can be taken with or without food (for most oral forms).
  • Do not swap between different clonidine products or formulations without medical guidance — the way your body absorbs them differs meaningfully.
  • Never stop clonidine suddenly; your dose should always be reduced gradually to avoid a rebound rise in blood pressure.
🤒Side effects — in detail▾

The most common side effects of clonidine include:

  • Drowsiness or sedation (very common, especially early in treatment)
  • Fatigue or low energy
  • Dry mouth
  • Dizziness
  • Constipation
  • Irritability
  • Trouble sleeping (insomnia)
  • Nightmares
  • Decreased appetite (when used with stimulants for ADHD)

More serious reactions that require prompt medical attention include a very slow heart rate (bradycardia), unusually low blood pressure, fainting, heart rhythm changes, or severe allergic reactions (widespread rash, hives, or facial swelling). Do not stop the medicine abruptly, as this can cause a dangerous rebound spike in blood pressure.

⚠️Warnings & precautions▾
  • Rebound hypertension: Stopping clonidine suddenly — especially at higher doses — can cause a rapid, dangerous rise in blood pressure, along with headache, nervousness, and a fast heart rate. Always taper the dose gradually as directed by your doctor.
  • Low blood pressure and slow heart rate: Clonidine can lower blood pressure and heart rate in a dose-related way. People with heart block, a history of fainting, dehydration, cardiovascular disease, or kidney disease are at higher risk and need closer monitoring.
  • Drowsiness and sedation: Sedation is very common. Avoid driving or operating machinery until you know how clonidine affects you. The risk is higher when combined with alcohol, sedatives, or other CNS depressants.
  • Heart conduction abnormalities: Clonidine can worsen slow heart rate and heart block (a disruption in the heart's electrical system), particularly in people also taking other heart-rate–slowing drugs. Severe cases have required emergency treatment.
  • Allergic reactions: People who have had a skin reaction to the clonidine patch may also react to oral clonidine. Generalized rash, hives, or swelling of the face or throat are signs of a serious allergic reaction.
🔀What it interacts with▾

Clonidine can interact with several types of medicines and substances — tell your prescriber and pharmacist about everything you take.

  • Other blood pressure medicines: Combining these with clonidine can lower blood pressure too much, increasing the risk of dizziness and fainting.
  • CNS depressants (sedatives, sleep aids, phenothiazines, barbiturates, benzodiazepines): These add to clonidine's sedating effects, increasing drowsiness and accident risk.
  • Alcohol: Alcohol worsens clonidine's sedating effects; avoid combining them.
  • Tricyclic antidepressants (e.g., amitriptyline, nortriptyline): These can raise blood pressure and reduce clonidine's ability to control it.
  • Digoxin, beta-blockers, and calcium channel blockers: These slow the heart on their own; combined with clonidine they can cause dangerously slow heart rate or heart block.

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it▾
  • Allergy to clonidine: Do not take clonidine if you have had a previous allergic reaction to it — this is a contraindication.
  • Heart rhythm or conduction problems: Tell your doctor about any history of sinus node dysfunction, heart block, or very slow heart rate before starting.
  • History of fainting or low blood pressure: Stay well hydrated and avoid overheating; these conditions raise the risk of fainting on clonidine.
  • Kidney disease: Clonidine is partly cleared by the kidneys; people with significant kidney impairment need a lower starting dose and careful monitoring.
  • Pregnancy: Published human data have not identified a clear risk of major birth defects, but discuss with your doctor. There is a pregnancy exposure registry for ADHD medications including clonidine.
  • Breastfeeding: Clonidine passes into breast milk. Breastfed infants should be monitored for sedation, poor feeding, or breathing changes.
  • Children under 6: Safety and effectiveness for ADHD have not been established in children under age 6.
  • Older adults: Elderly patients may be more sensitive to blood pressure and heart rate effects and may benefit from a lower starting dose.
  • Fertility: Animal studies suggest clonidine may affect fertility in both males and females; discuss this with your doctor if you are planning a pregnancy.
🚑If you take too much▾

Too much clonidine can cause a drop in blood pressure, very slow heart rate, extreme drowsiness, weak or absent reflexes, and slowed breathing — and in large overdoses, seizures, coma, or heart rhythm problems. Children are particularly vulnerable; even a small amount can be toxic in a young child. There is no specific antidote, so treatment focuses on supportive care, and you should call Poison Control or go to an emergency room immediately if overdose is suspected.

📡Pharmacodynamics — effects in the body▾

Clonidine is an antihypertensive (blood pressure–lowering) drug. By activating alpha-2 adrenergic receptors in the brainstem, it reduces the outflow of nerve signals that keep blood vessels constricted and the heart beating quickly. The result is lower peripheral resistance (less tension in the blood vessel walls), lower renal vascular resistance, a slower heart rate, and reduced blood pressure.

🔬Pharmacokinetics — how your body processes it▾

After an oral immediate-release dose, clonidine reaches peak blood levels in about 3 to 5 hours and stays in the body for 12 to 16 hours (its half-life — the time for half the drug to clear). Extended-release oral forms peak later and at lower levels than immediate-release — the two are not interchangeable on a milligram-for-milligram basis. About 40–60% of an oral dose leaves the body unchanged in urine within 24 hours, and roughly half is broken down by the liver. In people with severe kidney disease, the half-life can extend up to 41 hours, meaning the drug stays in the body much longer and dose adjustments are needed.

📦How to store it▾

Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) . Protect from light. Store and dispense ONYDA XR in the original bottle.

📄 Written from Clonidine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

138

Supplements & herbs that interact with Clonidine

138 supplements and herbal products have documented interactions with Clonidine in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 4
  • Moderate · 113
  • Minor · 21
ACTIVATED CHARCOAL Major AMERICAN HELLEBORE Major AMERICAN MISTLETOE Major TYRAMINE Major ADRAFINIL Moderate AGMATINE Moderate ALGAL OIL Moderate ANDROGRAPHIS Moderate +130 more
Every supplement checked against Clonidine — ranked by severity The full interaction hub: 4 major · 113 moderate · 21 minor · every one linked to its full report. Check Clonidine against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

1

Nutrient depletion considerations

Clonidine has been associated with lower levels of 1 nutrient in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

COENZYME Q10 Insufficient Evidence
See the full Clonidine nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Clonidine — the kind of thing our pharmacy team would talk through with you at the counter.

What exactly is clonidine used for — I've seen it mentioned for totally different things? ▾
You're right that it's used for several different conditions — that can be confusing. Depending on the product, clonidine is prescribed to lower high blood pressure in adults, to treat ADHD in children and teenagers ages 6 to 17, or — as an injection given in a hospital setting — to help control severe cancer pain when opioids alone aren't working. The form and brand your prescription is for will match the condition it's meant to treat, so it's worth confirming with your pharmacist which use applies to you.
Will clonidine make me too sleepy to function? ▾
Drowsiness is one of the most common side effects, especially when you first start or when your dose goes up. Many people find it eases a bit over time. Until you know how it affects you, avoid driving, operating heavy machinery, or drinking alcohol. If the drowsiness is really interfering with your day, let your prescriber know — timing the larger dose at bedtime can sometimes help.
Can I just stop taking clonidine if I feel like I don't need it anymore? ▾
Please don't stop it suddenly without talking to your doctor first. Stopping clonidine abruptly can cause a rebound spike in blood pressure — sometimes sharp — along with headache, a racing heart, and feeling shaky or anxious. Your dose needs to be reduced gradually over days to weeks to avoid this. Even if you're feeling great, always check with your prescriber before making any changes.
Are there any medicines or supplements I should avoid while taking clonidine? ▾
Yes, a few important ones. Blood pressure medicines can combine with clonidine to lower your pressure too much. Sedatives, sleep aids, and alcohol all add to clonidine's drowsiness effect, making it stronger and more risky. Certain heart medicines — like beta-blockers, digoxin, and some calcium channel blockers — can dangerously slow your heart rate when combined with clonidine. And tricyclic antidepressants (an older type of antidepressant) can actually blunt clonidine's blood pressure–lowering effect. Always give your pharmacist a full list of everything you take, including over-the-counter medicines and supplements.
Is clonidine safe to take during pregnancy or while breastfeeding? ▾
Decades of human experience with clonidine during pregnancy haven't shown a clear pattern of birth defects, but no medicine in pregnancy is risk-free, so this is a conversation to have with your doctor. If you're using it for ADHD, there's a pregnancy registry you can enroll in to help track outcomes. For breastfeeding, clonidine does pass into breast milk. Breastfed babies should be watched for unusual sleepiness, poor feeding, or breathing changes — and your doctor can help you weigh the benefits and risks.
My child was just prescribed clonidine for ADHD — what should I watch for? ▾
The most common things to watch for in children are drowsiness, fatigue, and irritability — these are the side effects seen most often in the ADHD studies. You'll also want to monitor their blood pressure and heart rate as directed by your child's doctor, especially when starting or when the dose goes up. Keep clonidine safely out of reach — even a very small amount can be toxic to young children who take it accidentally. And never stop the medicine suddenly; always taper as your prescriber directs.
Is Clonidine available over the counter? ▾
Clonidine is dispensed by prescription according to its FDA labeling, so it isn't sold over the counter. Your prescriber and pharmacist will determine if it's appropriate for you.
When was Clonidine first available? ▾
Clonidine has been available in the United States since at least 1974, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Clonidine? ▾
Clonidine is supplied by 88 manufacturers listed in the FDA NDC Directory, including Bryant Ranch Prepack, Remedyrepack Inc., A-S Medication Solutions.

💬 Answers drafted from Clonidine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

📊Clonidine supplement interactions138 checked — ranked by severity 🌿Drug & Supplement CheckerClonidine vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Clonidine NDCs & costs 🅰️Browse Drugs A–ZLook up any medication

💊 How Clonidine comes

Clonidine is available in 6 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Tablet

By mouth
How this form is used
What it may be used for
  • Clonidine Hydrochloride tablets are used to treat high blood pressure in adults
  • Clonidine Hydrochloride tablets may be used alone or with other blood pressure medicines
Important instructions
  • Clonidine Hydrochloride tablets are taken by mouth, typically twice daily (morning and bedtime)
  • Taking the larger portion of the daily dose at bedtime may help reduce dry mouth and daytime drowsiness
  • Dose is adjusted based on individual blood pressure response; patients with kidney disease should start at a lower dose
  • Do not stop taking Clonidine Hydrochloride tablets suddenly without talking to your doctor
Available strengths 4 strengths
0.05 mg 0.1 mg 0.2 mg 0.3 mg
321 FDA-listed product records ⓘ

Skin patch

Through the skin
Brands Catapres-TTS Catapres-TTS-1 Catapres-TTS-2 Catapres-TTS-3 Clonidine transdermal system
How this form is used
What it may be used for
  • Catapres-TTS skin patches are used to treat high blood pressure in adults, alone or with other antihypertensive medicines
  • Clonidine transdermal patches are used to treat high blood pressure in adults
Important instructions
  • Apply the skin patch once every 7 days to a hairless area of intact skin on the upper outer arm or chest
  • Each new patch should be placed on a different skin site than the previous one
  • If the patch loosens before 7 days, press the adhesive cover directly over the patch to keep it in place
  • Catapres-TTS therapy is started at the lowest strength and adjusted after one to two weeks if blood pressure is not adequately controlled
Available strengths 12 strengths
0.1 mg/24h 0.1 mg/d CLONIDINE 0.1 mg/24h CLONIDINE 0.1 mg/d 0.2 mg/24h 0.2 mg/d
Show 6 more strengths Show fewer strengths
CLONIDINE 0.2 mg/24h CLONIDINE 0.2 mg/d 0.3 mg/24h 0.3 mg/d CLONIDINE 0.3 mg/24h CLONIDINE 0.3 mg/d
46 FDA-listed product records ⓘ

Extended-release tablet

By mouth
Brands Kapvay Nexiclon XR
How this form is used
What it may be used for
  • Clonidine hydrochloride extended-release tablets (including Kapvay) are used to treat ADHD in children and adolescents ages 6 to 17, either alone or with stimulant medications
  • Nexiclon XR extended-release tablets are used to treat high blood pressure in adults, alone or with other antihypertensive medicines
Important instructions
  • Clonidine hydrochloride extended-release tablets are taken by mouth with or without food
  • Swallow the extended-release tablet whole — do not crush, chew, or break it
  • Nexiclon XR is taken once daily, with the starting dose recommended at bedtime; dose is adjusted at weekly intervals based on blood pressure response
  • Do not substitute extended-release tablets for other clonidine products on a milligram-for-milligram basis, as absorption differs
Available strengths 2 strengths
0.1 mg 0.17 mg
40 FDA-listed product records ⓘ

Injection

By injection · Into a vein · Into the epidural space
Brands Clonidine Hci Duraclon
How this form is used
What it may be used for
  • Duraclon epidural injection is used alongside opioid pain medicines to treat severe cancer pain not adequately controlled by opioids alone
  • Clonidine hydrochloride injection is used in combination with opiates for severe cancer pain; it is more likely to help neuropathic (nerve) pain than other types
  • The safety of clonidine injection has only been established in a carefully selected group of cancer patients after opioid treatment has proven insufficient
Important instructions
  • Duraclon and clonidine hydrochloride injection are given by continuous epidural infusion by a trained healthcare team — not self-administered
  • Patients are closely monitored for the first several days of epidural infusion to assess response and watch for side effects
  • Dose is adjusted based on pain relief and any side effects that occur
  • Patients with kidney problems may require dose adjustment and careful monitoring
Available strengths 5 strengths
0.1 mg/mL 100 mcg/mL 0.5 mg/mL 500 mcg/mL 5 mg/mL
16 FDA-listed product records ⓘ

Oral solution

By mouth
Brands Javadin Qlonilik
How this form is used
What it may be used for
  • Javadin oral solution is used to treat high blood pressure in adults
Important instructions
  • Javadin is taken by mouth twice daily (morning and bedtime) with or without food
  • The dose is started low and adjusted at weekly intervals based on blood pressure response
  • The higher portion of the daily dose is taken at bedtime
  • Do not stop Javadin suddenly without your doctor's guidance
Available strengths 2 strengths
20 mcg/mL 0.05 mg/mL
2 FDA-listed product records ⓘ

Extended-release oral suspension

By mouth
Brands Onyda Xr
How this form is used
What it may be used for
  • Onyda XR is used to treat ADHD in children and adolescents ages 6 and older, either as the sole treatment or added to a CNS stimulant medication
Important instructions
  • Onyda XR is taken by mouth once daily at bedtime, with or without food
  • Onyda XR dose is started low and increased in small steps at weekly intervals up to the maximum recommended amount
  • Do not substitute Onyda XR for other clonidine products on a milligram-for-milligram basis
  • When stopping Onyda XR, the dose should be tapered gradually — do not stop suddenly
Available strengths 1 strength
0.1 mg/mL
1 FDA-listed product record ⓘ

📊 Clonidine across the U.S. market

How Clonidine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

6
Dose forms ⓘ
88
Manufacturers
17
Brand names
446
FDA-listed product records ⓘ
1974
First marketed ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (20) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Bryant Ranch Prepack16%
Remedyrepack Inc.8%
A-S Medication Solutions7%
Actavis Pharma, Inc.5%
TruPharma, LLC5%
NuCare Pharmaceuticals,Inc.5%
Other makers55%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Clonidine is used

A general measure of how commonly Clonidine is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Clonidine is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

5,852,758
Medicaid prescriptions filled (Q1–Q4 2025)
$82.3M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Clonidine prescribed? Of the 1,596 medications we measure, Clonidine ranks #30 by Medicaid prescriptions — more than 98% of them.

Where Clonidine ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #30 of 1,596
#25 Fluoxetine 6,471,546 Rx #26 Escitalopram 6,377,287 Rx #27 Aspirin 6,339,210 Rx #28 Losartan 5,992,816 Rx #29 Metoprolol 5,974,670 Rx #30 Clonidine 5,852,758 Rx #31 Semaglutide 5,813,664 Rx #32 Pantoprazole 5,789,599 Rx #33 Quetiapine 5,743,048 Rx #34 Triamcinolone 5,724,276 Rx #35 Methylphenidate 5,663,940 Rx

Utilization by Clonidine product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 0.1 mg oral tablet is the most-dispensed Clonidine product — about 59% of these Medicaid prescriptions.

clonidine hydrochloride 0.1 MG Oral Tablet Most dispensed

3,477,328 Medicaid prescriptions (Q1–Q4 2025) 59% of Clonidine prescriptions shown $27.5M gross reimbursement (before rebates) ≈ $7.90 per prescription (gross)

Summed across the 22 of 258 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 884173

clonidine hydrochloride 0.2 MG Oral Tablet

1,333,134 Medicaid prescriptions (Q1–Q4 2025) 23% of Clonidine prescriptions shown $10.5M gross reimbursement (before rebates) ≈ $7.91 per prescription (gross)

Summed across the 20 of 148 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 884185

clonidine hydrochloride 0.3 MG Oral Tablet

476,997 Medicaid prescriptions (Q1–Q4 2025) 8% of Clonidine prescriptions shown $3.9M gross reimbursement (before rebates) ≈ $8.11 per prescription (gross)

Summed across the 13 of 93 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 884189

12 HR clonidine hydrochloride 0.1 MG Extended Release Oral Tablet

411,567 Medicaid prescriptions (Q1–Q4 2025) 7% of Clonidine prescriptions shown $13.1M gross reimbursement (before rebates) ≈ $32 per prescription (gross)

Summed across the 7 of 25 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1013930

168 HR clonidine 0.00417 MG/HR Transdermal System

47,779 Medicaid prescriptions (Q1–Q4 2025) <1% of Clonidine prescriptions shown $2M gross reimbursement (before rebates) ≈ $41 per prescription (gross)

Summed across the 4 of 13 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 998671

168 HR clonidine 0.00833 MG/HR Transdermal System

37,035 Medicaid prescriptions (Q1–Q4 2025) <1% of Clonidine prescriptions shown $2.2M gross reimbursement (before rebates) ≈ $59 per prescription (gross)

Summed across the 4 of 14 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 998675

168 HR clonidine 0.0125 MG/HR Transdermal System

33,771 Medicaid prescriptions (Q1–Q4 2025) <1% of Clonidine prescriptions shown $2.6M gross reimbursement (before rebates) ≈ $78 per prescription (gross)

Summed across the 4 of 13 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 998679

24 HR clonidine hydrochloride 0.1 MG/ML Extended Release Suspension

28,622 Medicaid prescriptions (Q1–Q4 2025) <1% of Clonidine prescriptions shown $19.2M gross reimbursement (before rebates) ≈ $671 per prescription (gross)

Summed across the 1 of 6 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2690727

10 ML clonidine hydrochloride 0.1 MG/ML Injection

4,381 Medicaid prescriptions (Q1–Q4 2025) <1% of Clonidine prescriptions shown $257,167 gross reimbursement (before rebates) ≈ $59 per prescription (gross)

Summed across the 3 of 6 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 884221

24 HR clonidine 0.17 MG Extended Release Oral Tablet

2,065 Medicaid prescriptions (Q1–Q4 2025) <1% of Clonidine prescriptions shown $1.1M gross reimbursement (before rebates) ≈ $529 per prescription (gross)

Summed across the 1 of 3 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 885880

10 ML clonidine hydrochloride 0.5 MG/ML Injection

79 Medicaid prescriptions (Q1–Q4 2025) <1% of Clonidine prescriptions shown $1,744 gross reimbursement (before rebates) ≈ $22 per prescription (gross)

Summed across the 1 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 884225

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Clonidine, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 80 of 583 listed Clonidine NDCs with Medicaid activity.

🔍 Compare Clonidine products

A representative set of FDA-listed product records for Clonidine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 200 of 446 products — FDA National Drug Code Directory. See every product, package size and price: browse all 446 Clonidine NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Clonidine RxCUI 2599 8 dose forms · 16 strengths
  1. Dose form (SCDF) Extended Release Oral Capsule RxCUI 371581 No current FDA listing
    Clinical drug / strength (SCD) hydrochloride 0.25 MG RxCUI 892795
  4. Dose form (SCDF) Injectable Solution RxCUI 371582 In current FDA listings
    Clinical drug / strength (SCD) hydrochloride 0.15 MG/ML RxCUI 892793
  6. Dose form (SCDF) Oral Solution RxCUI 2725552 In current FDA listings
    Clinical drug / strength (SCD) hydrochloride 0.02 MG/ML RxCUI 2725554

Look up RxCUI 2599 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Catapres Kapvay Jenloga Nexiclon Onyda Javadin Duraclon Clonidine transdermal system Catapres-TTS-1 Catapres-TTS-2 Catapres-TTS-3 Catapres-TTS Clonidine Hci Nexiclon XR Onyda Xr Qlonilik

🏭 Manufacturers & labelers

Bryant Ranch Prepack 60 Remedyrepack Inc. 30 A-S Medication Solutions 27 Actavis Pharma, Inc. 18 TruPharma, LLC 17 NuCare Pharmaceuticals,Inc. 17 Technomed Inc. 12 BluePoint Laboratories 11 Preferred Pharmaceuticals Inc. 11 PD-Rx Pharmaceuticals, Inc. 11 Method Pharmaceuticals, LLC 9 Mylan Pharmaceuticals Inc. 9 American Health Packaging 8 RPK Pharmaceuticals, Inc. 8 Solco Healthcare LLC 8 Unichem Pharmaceuticals (USA), Inc. 7 Alembic Pharmaceuticals Limited 7 DirectRX 7 Proficient Rx LP 6 XGen Pharmaceuticals DJB, Inc. 6 Denton Pharma, Inc. DBA Northwind Pharmaceuticals 6 Northwind Health Company, LLC 6 NCS HealthCare of KY, LLC dba Vangard Labs 6 AvPAK 6

…and 16 more on the FDA NDC directory.

RxNorm drug class

Clonidine belongs to the Central alpha-2 Adrenergic Agonist class.

Pharmacologic class Central alpha-2 Adrenergic Agonist
Drug family (ATC) Imidazoline receptor agonists, Other antimigraine preparations, Sympathomimetics in glaucoma therapy
How it works Adrenergic alpha2-Agonists

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Jan 11, 2024
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Clonidine.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Clonidine after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
132
NDC products indexed
446
Distinct labelers/manufacturers represented
88
Linked representative label ⓘ
Palmetto Pharmaceuticals Inc.
Linked label effective
Jan 11, 2024
Composite sections available
23
Linked SPL Set ID
e93324f1-ad83-7bbe-e053-2995a90a8c9e
Linked SPL Document ID
0eb6eb87-c779-3b79-e063-6294a90a5944
Open the linked representative label on DailyMed ↗
NDC package records associated with this linked SPL 1

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 132 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Palmetto Pharmaceuticals Inc. is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.