Clonidine

52 interactions 4 explained in plain English
Also sold as: Duraclon Javadin Kapvay Onyda
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Clonidine Amitriptyline Elavil Explained Reduced antihypertensive effects and may counteract the hypotensive effects of cloNIDine Details Clonidine Atenolol Tenormin Explained An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Acebutolol Sectral® An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Amlodipine Amvaz® An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Betaxolol Betoptic S An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Betaxolol Ophthalmic Betoptic® An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Bisoprolol Zebeta® An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Digoxin Cardoxin® An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Esmolol Brevibloc An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Felodipine Plendil® An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Isradipine DynaCirc® An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Labetalol Normodyne® An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Levobunolol Ophthalmic AKBeta® An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Nadolol Corgard An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Nebivolol Bystolic An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Nicardipine Cardene An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Nifedipine Adalat® An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Nimodipine Nimotop An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Nisoldipine Sular An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Clonidine Olodaterol Oral Inhalation Striverdi An increased risk of clinically significant cardiovascular effects and fatalities and an increased/potentiated sympathetic effects... Details Clonidine Penbutolol Levatol® An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details

Moderate

Clonidine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of sedation and somnolence Details Clonidine Buprenorphine Belbuca Explained An increased risk of sedation and somnolence Details Clonidine Aripiprazole Injection Abilify An increased risk of sedation and somnolence Details Clonidine Asenapine Transdermal Patch Secuado Induction or exacerbation of orthostatic regulation disturbances and an increased risk of sedation and somnolence Details Clonidine Butorphanol Injection Butorphic An increased risk of sedation and somnolence Details Clonidine Butorphanol Nasal Spray Stadol® NS An increased risk of sedation and somnolence Details Clonidine Cetirizine Injection Aller-Tec An increased risk of sedation and somnolence Details Clonidine Cetirizine Ophthalmic Zerviate An increased risk of sedation and somnolence Details Clonidine Cyclosporine Injection Atopica An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Clonidine Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Clonidine Diazepam Nasal Spray Valtoco An increased risk of sedation and somnolence Details Clonidine Diazepam Rectal Diastat An increased risk of sedation and somnolence Details Clonidine Diphenhydramine Injection Banophen An increased risk of sedation and somnolence Details Clonidine Diphenhydramine Topical Afterbite with Antihistamine An increased risk of sedation and somnolence Details Clonidine Esketamine Nasal Spray Spravato An increased risk of sedation and somnolence Details Clonidine Fentanyl Transdermal Patch Duragesic® An increased risk of sedation and somnolence Details Clonidine Hydromorphone Injection Dilaudid An increased risk of sedation and somnolence Details Clonidine Hydromorphone Rectal available generically An increased risk of sedation and somnolence Details Clonidine Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hypoglycemia or hyperglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.