Palonosetron Injection

113 interactions 87 cited references

Also sold as: Aloxi® Posfrea

About Palonosetron Injection

Palonosetron injection is used to prevent nausea and vomiting that may occur within 24 hours after receiving cancer chemotherapy or surgery. It is also used to prevent delayed nausea and vomiting that may occur several days after receiving certain chemotherapy medications. Palonosetron injection is in a class of medica… Read the full Palonosetron Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Tranylcypromine Phenelzine Apomorphine Alfentanil Almotriptan Amineptine

3 Contraindicated 110 Major

All (113) Contraindicated (3) Major (110)

Contraindicated

Palonosetron Injection Apomorphine Apokyn Increased risk of profound hypotension and altered consciousness Details Palonosetron Injection Phenelzine Nardil An increased risk of serotonin syndrome Details Palonosetron Injection Tranylcypromine Parnate An increased risk of serotonin syndrome Details

Major

Palonosetron Injection Alfentanil Increased risk of serotonin syndrome Details Palonosetron Injection Almotriptan An increased risk of serotonin syndrome Details Palonosetron Injection Amineptine An increased risk of serotonin syndrome Details Palonosetron Injection Amitriptyline Elavil An increased risk of serotonin syndrome Details Palonosetron Injection Amitriptylinoxide An increased risk of serotonin syndrome Details Palonosetron Injection Amoxapine An increased risk of serotonin syndrome Details Palonosetron Injection Amphetamine Dexedrine An increased risk of serotonin syndrome Details Palonosetron Injection Anileridine An increased risk of serotonin syndrome Details Palonosetron Injection Benzhydrocodone An increased risk of serotonin syndrome Details Palonosetron Injection Benzphetamine An increased risk of serotonin syndrome Details Palonosetron Injection Brompheniramine Respa-BR An increased risk of serotonin syndrome Details Palonosetron Injection Buprenorphine Belbuca An increased risk of serotonin syndrome Details Palonosetron Injection Buspirone Bucapsol An increased risk of serotonin syndrome Details Palonosetron Injection Butorphanol Butorphic Increased risk of serotonin syndrome Details Palonosetron Injection Carbamazepine Carbatrol An increased risk of serotonin syndrome Details Palonosetron Injection Chlorpheniramine An increased risk of serotonin syndrome Details Palonosetron Injection Citalopram Celexa An increased risk of serotonin syndrome Details Palonosetron Injection Clomipramine Anafranil An increased risk of serotonin syndrome Details Palonosetron Injection Cocaine Goprelto An increased risk of serotonin syndrome Details Palonosetron Injection Codeine Tuzistra XR® (as a combination product containing Chlorpheniramine, Codeine) Increased risk of serotonin syndrome Details Palonosetron Injection Cyclobenzaprine Amrix An increased risk of serotonin syndrome Details Palonosetron Injection Desipramine Norpramin An increased risk of serotonin syndrome Details Palonosetron Injection Desvenlafaxine Pristiq An increased risk of serotonin syndrome Details Palonosetron Injection Dextroamphetamine Dexedrine An increased risk of serotonin syndrome Details Palonosetron Injection Dextromethorphan Delsym An increased risk of serotonin syndrome Details Palonosetron Injection Dibenzepin An increased risk of serotonin syndrome Details Palonosetron Injection Difenoxin An increased risk of serotonin syndrome Details Palonosetron Injection Dihydrocodeine Increased risk of serotonin syndrome Details Palonosetron Injection Diphenoxylate An increased risk of serotonin syndrome Details Palonosetron Injection Dolasetron Anzemet An increased risk of serotonin syndrome Details Palonosetron Injection Doxepin Prudoxin An increased risk of serotonin syndrome Details Palonosetron Injection Duloxetine An increased risk of serotonin syndrome Details Palonosetron Injection Eletriptan Relpax An increased risk of serotonin syndrome Details Palonosetron Injection Escitalopram Lexapro An increased risk of serotonin syndrome Details Palonosetron Injection Ethylmorphine An increased risk of serotonin syndrome Details Palonosetron Injection Fenfluramine An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Palonosetron Injection Fentanyl An increased risk of serotonin syndrome Details

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