Entrectinib

Generic name: Pronounced as (en trek' ti nib)
Brand names
  • Rozlytrek®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 10/15/2019

Entrectinib is used to treat a certain type of non-small cell lung cancer (NSCLC) in adults that has spread to other parts of the body. It is also used to treat certain types of solid tumors in adults and children 12 years of age and older that cannot be treated by surgery or that has spread to other parts of the body and that worsened after treatment with other chemotherapy medications. Entrectinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

Entrectinib comes as a capsule to take by mouth. It is usually taken with or without food once daily. Take entrectinib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take entrectinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not open, chew, or crush them.

If you vomit immediately after you take entrectinib, take another dose as soon as possible.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking entrectinib,

  • tell your doctor and pharmacist if you are allergic to entrectinib, any other medications, or any of the ingredients in entrectinib capsules. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the following: aprepitant (Emend), certain antifungal medications such as fluconazole (Diflucan), itraconazole (Omel, Sporanox), or ketoconazole; certain medications for arrhythmias such as amiodarone (Nexterone, Pacerone), procainamide, quinidine (in Nuedexta), and sotalol (Betapace, Sorine, Sotylize); azithromycin (Zithromax); clarithromycin (Biaxin, in Prevpac); diltiazem (Cardizem, Tiazac, others); erythromycin (E.E.S., Erythrocin, others); enzalutamide (Xtandi); certain HIV medications such as efavirenz (Sustiva, in Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, in Kaletra, others), or saquinavir (Invirase); lithium (Lithobid); modafinil (Provigil); nefazodone; oxcarbazepine (Trileptal); phenobarbital; phenytoin (Dilantin, Phenytek); pioglitazone (Actos, in Actoplus, Duetact, Oseni); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, in Rifater); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); and verapamil (Calan). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with entrectinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor what herbal products you are taking, especially St. John's Wort.

  • tell your doctor if you have or have ever had a nervous system condition, a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death), a slow or irregular heartbeat, a heart attack, heart failure, or heart or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or if you plan on fathering a child. If you are female, you will need to take a pregnancy test before you start treatment and use birth control to prevent pregnancy during your treatment and for at least 5 weeks after your final dose. If you are a male, you and your partner should use birth control during your treatment with entrectinib and for 3 months after your final dose. Talk to your doctor about birth control methods that you can use during your treatment. If you or your partner become pregnant while taking entrectinib, call your doctor immediately. Entrectinib may harm the fetus.

  • tell your doctor if you are breastfeeding. You should not breastfeed while you are taking entrectinib and for 7 days after the final dose.

  • you should know that entrectinib may make cause dizziness or confusion. Do not drive a car or operate machinery until you know how this medication affects you.

Do not eat grapefruit or drink grapefruit juice while taking this medication.

If you miss a dose by less than 12 hours, take the missed dose as soon as you remember it and then take the next dose at the scheduled time. However, if you miss a dose by more than 12 hours, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Entrectinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • tiredness

    • constipation

    • diarrhea

    • taste changes

    • headache

    • cough, fever, or other signs of infection

    • muscle or joint pain

    • back pain

    • weight changes

    • rash

    • difficulty falling or staying asleep

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

    • difficulty with learning, memory, attention, or problem solving

    • mood changes such as anxiety, depression, confusion, or agitation

    • bone pain or difficulty moving

    • vision problems or changes in vision

    • joint pain, stiffness, redness, or swelling

    • pain in upper right part of the stomach, yellowing of skin or eyes, loss of appetite, or bleeding or bruising easily

    • shortness of breath; difficulty breathing when lying down; or swelling of the arms, legs, hands, or feet

  • Entrectinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will order a lab test before you begin your treatment to see whether your cancer can be treated with entrectinib. Your doctor may order certain lab tests before and during your treatment to check your body's response to entrectinib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The risk or severity of QTc prolongation can be increased when Moxifloxacin is combined with Entrectinib.
Delavirdine Delavirdine The metabolism of Entrectinib can be decreased when combined with Delavirdine.
Dolasetron Dolasetron The risk or severity of QTc prolongation can be increased when Dolasetron is combined with Entrectinib.
Anagrelide Anagrelide The risk or severity of QTc prolongation can be increased when Anagrelide is combined with Entrectinib.
Cilostazol Cilostazol The risk or severity of QTc prolongation can be increased when Cilostazol is combined with Entrectinib.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Entrectinib can be decreased when combined with Erythromycin.
Fenofibrate Fenofibrate The metabolism of Entrectinib can be decreased when combined with Fenofibrate.
Methylergonovine Methylergonovine The metabolism of Entrectinib can be decreased when combined with Methylergometrine.
Paregoric Paregoric The serum concentration of Morphine can be increased when it is combined with Entrectinib.
Penbutolol Penbutolol The risk or severity of QTc prolongation can be increased when Acebutolol is combined with Entrectinib.
Tacrolimus Tacrolimus The risk or severity of QTc prolongation can be increased when Tacrolimus is combined with Entrectinib.
Tizanidine Tizanidine The risk or severity of QTc prolongation can be increased when Tizanidine is combined with Entrectinib.
Triamcinolone Triamcinolone The metabolism of Entrectinib can be increased when combined with Triamcinolone.
Doxycycline Injection Doxycycline Injection The metabolism of Entrectinib can be decreased when combined with Doxycycline.
Famotidine Injection Famotidine Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Entrectinib.
Fluconazole Injection Fluconazole Injection The metabolism of Entrectinib can be decreased when combined with Fluconazole.
Foscarnet Injection Foscarnet Injection The risk or severity of QTc prolongation can be increased when Foscarnet is combined with Entrectinib.
Levofloxacin Injection Levofloxacin Injection The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Entrectinib.
Meperidine Injection Meperidine Injection The metabolism of Entrectinib can be increased when combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Entrectinib can be increased when combined with Methylprednisolone.
Metoclopramide Injection Metoclopramide Injection The risk or severity of QTc prolongation can be increased when Metoclopramide is combined with Entrectinib.
Metronidazole Injection Metronidazole Injection The risk or severity of QTc prolongation can be increased when Metronidazole is combined with Entrectinib.
Morphine Injection Morphine Injection The serum concentration of Morphine can be increased when it is combined with Entrectinib.
Cyclosporine Cyclosporine The metabolism of Entrectinib can be decreased when combined with Cyclosporine.
Ondansetron Ondansetron The risk or severity of QTc prolongation can be increased when Ondansetron is combined with Entrectinib.
Granisetron Granisetron The risk or severity of QTc prolongation can be increased when Granisetron is combined with Entrectinib.
Olanzapine Olanzapine The risk or severity of QTc prolongation can be increased when Olanzapine is combined with Entrectinib.
Dofetilide Dofetilide The risk or severity of QTc prolongation can be increased when Dofetilide is combined with Entrectinib.
Hydroxychloroquine Hydroxychloroquine The risk or severity of QTc prolongation can be increased when Hydroxychloroquine is combined with Entrectinib.
Orlistat Orlistat The metabolism of Entrectinib can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Oxcarbazepine can be increased when combined with Entrectinib.
Anakinra Anakinra The metabolism of Entrectinib can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Entrectinib.
Trimipramine Trimipramine The risk or severity of QTc prolongation can be increased when Trimipramine is combined with Entrectinib.
Etanercept Injection Etanercept Injection The metabolism of Entrectinib can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Entrectinib can be increased when combined with Modafinil.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Entrectinib.
Sirolimus Sirolimus The serum concentration of Entrectinib can be increased when it is combined with Sirolimus.
Epinephrine Injection Epinephrine Injection The metabolism of Entrectinib can be decreased when combined with Epinephrine.
Escitalopram Escitalopram The risk or severity of QTc prolongation can be increased when Escitalopram is combined with Entrectinib.
Zonisamide Zonisamide The risk or severity of QTc prolongation can be increased when Zonisamide is combined with Entrectinib.
Adalimumab Injection Adalimumab Injection The metabolism of Entrectinib can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The risk or severity of QTc prolongation can be increased when Aripiprazole is combined with Entrectinib.
Atomoxetine Atomoxetine The risk or severity of QTc prolongation can be increased when Atomoxetine is combined with Entrectinib.
Teriparatide Injection Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Entrectinib.
Atazanavir Atazanavir The metabolism of Entrectinib can be decreased when combined with Atazanavir.
Mefloquine Mefloquine The risk or severity of QTc prolongation can be increased when Mefloquine is combined with Entrectinib.
Rosuvastatin Rosuvastatin The metabolism of Entrectinib can be decreased when combined with Rosuvastatin.
Vardenafil Vardenafil The risk or severity of QTc prolongation can be increased when Vardenafil is combined with Entrectinib.
Alfuzosin Alfuzosin The risk or severity of QTc prolongation can be increased when Alfuzosin is combined with Entrectinib.
Aprepitant Aprepitant The metabolism of Entrectinib can be decreased when combined with Aprepitant.
Tegaserod Tegaserod The serum concentration of Tegaserod can be increased when it is combined with Entrectinib.
Gemifloxacin Gemifloxacin The risk or severity of QTc prolongation can be increased when Gemifloxacin is combined with Entrectinib.
Progesterone Progesterone The metabolism of Entrectinib can be increased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The risk or severity of QTc prolongation can be increased when Apomorphine is combined with Entrectinib.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Entrectinib.
Infliximab Injection Infliximab Injection The metabolism of Entrectinib can be increased when combined with Infliximab.
Protriptyline Protriptyline The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Entrectinib.
Rifaximin Rifaximin The metabolism of Entrectinib can be increased when combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Entrectinib can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Entrectinib can be decreased when combined with Norethisterone.
Bosentan Bosentan The metabolism of Entrectinib can be increased when combined with Bosentan.
Erlotinib Erlotinib The risk or severity of QTc prolongation can be increased when Erlotinib is combined with Entrectinib.
Solifenacin Solifenacin The risk or severity of QTc prolongation can be increased when Solifenacin is combined with Entrectinib.
Voriconazole Voriconazole The metabolism of Entrectinib can be decreased when combined with Voriconazole.
Ibandronate Ibandronate The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Entrectinib.
Pregabalin Pregabalin The risk or severity of QTc prolongation can be increased when Pregabalin is combined with Entrectinib.
Deferasirox Deferasirox The metabolism of Entrectinib can be increased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Entrectinib can be decreased when combined with Tipranavir.
Felbamate Felbamate The risk or severity of QTc prolongation can be increased when Felbamate is combined with Entrectinib.
Ranolazine Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Entrectinib.
Abatacept Injection Abatacept Injection The metabolism of Entrectinib can be increased when combined with Abatacept.
Imatinib Imatinib The risk or severity of QTc prolongation can be increased when Imatinib is combined with Entrectinib.
Sitagliptin Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Entrectinib.
Gefitinib Gefitinib The metabolism of Entrectinib can be decreased when combined with Gefitinib.
Albuterol Albuterol The risk or severity of QTc prolongation can be increased when Salbutamol is combined with Entrectinib.
Paliperidone Paliperidone The risk or severity of QTc prolongation can be increased when Paliperidone is combined with Entrectinib.
Bortezomib Bortezomib The risk or severity of QTc prolongation can be increased when Bortezomib is combined with Entrectinib.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of QTc prolongation can be increased when Oxaliplatin is combined with Entrectinib.
Posaconazole Posaconazole The metabolism of Entrectinib can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Entrectinib can be decreased when combined with Primaquine.
Darunavir Darunavir The metabolism of Entrectinib can be decreased when combined with Darunavir.
Dimenhydrinate Dimenhydrinate The risk or severity of QTc prolongation can be increased when Dimenhydrinate is combined with Entrectinib.
Vorinostat Vorinostat The risk or severity of QTc prolongation can be increased when Vorinostat is combined with Entrectinib.
Sorafenib Sorafenib The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Entrectinib.
Sunitinib Sunitinib The risk or severity of QTc prolongation can be increased when Sunitinib is combined with Entrectinib.
Lapatinib Lapatinib The risk or severity of QTc prolongation can be increased when Lapatinib is combined with Entrectinib.
Levocetirizine Levocetirizine The risk or severity of QTc prolongation can be increased when Levocetirizine is combined with Entrectinib.
Dasatinib Dasatinib The risk or severity of QTc prolongation can be increased when Dasatinib is combined with Entrectinib.
Armodafinil Armodafinil The metabolism of Entrectinib can be increased when combined with Armodafinil.
Ivermectin Ivermectin The metabolism of Entrectinib can be increased when combined with Ivermectin.
Temsirolimus Temsirolimus The serum concentration of Entrectinib can be increased when it is combined with Temsirolimus.
Nilotinib Nilotinib The metabolism of Entrectinib can be decreased when combined with Nilotinib.
Toremifene Toremifene The risk or severity of QTc prolongation can be increased when Toremifene is combined with Entrectinib.
Bexarotene Bexarotene The metabolism of Entrectinib can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Entrectinib can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Entrectinib can be decreased when combined with Chloramphenicol.
Etravirine Etravirine The metabolism of Entrectinib can be increased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Arsenic trioxide is combined with Entrectinib.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Entrectinib can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The metabolism of Entrectinib can be decreased when combined with Desvenlafaxine.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Entrectinib.
Pilocarpine Pilocarpine The metabolism of Entrectinib can be decreased when combined with Pilocarpine.
Flecainide Flecainide The risk or severity of QTc prolongation can be increased when Flecainide is combined with Entrectinib.
Certolizumab Injection Certolizumab Injection The metabolism of Entrectinib can be increased when combined with Certolizumab pegol.
Mitotane Mitotane The metabolism of Entrectinib can be increased when combined with Mitotane.
Rufinamide Rufinamide The metabolism of Entrectinib can be increased when combined with Rufinamide.
Silodosin Silodosin The serum concentration of Silodosin can be increased when it is combined with Entrectinib.
Midazolam Midazolam The metabolism of Entrectinib can be decreased when combined with Midazolam.
Milnacipran Milnacipran The metabolism of Entrectinib can be decreased when combined with Milnacipran.
Degarelix Injection Degarelix Injection The risk or severity of QTc prolongation can be increased when Degarelix is combined with Entrectinib.
Betaxolol Betaxolol The risk or severity of QTc prolongation can be increased when Betaxolol is combined with Entrectinib.
Iloperidone Iloperidone The risk or severity of QTc prolongation can be increased when Iloperidone is combined with Entrectinib.
Lacosamide Lacosamide The metabolism of Entrectinib can be decreased when combined with Lacosamide.
Everolimus Everolimus The serum concentration of Everolimus can be increased when it is combined with Entrectinib.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Entrectinib.
Dronedarone Dronedarone The metabolism of Entrectinib can be decreased when combined with Dronedarone.
Telavancin Injection Telavancin Injection The risk or severity of QTc prolongation can be increased when Telavancin is combined with Entrectinib.
Romidepsin Injection Romidepsin Injection The risk or severity of QTc prolongation can be increased when Romidepsin is combined with Entrectinib.
Topotecan Topotecan The metabolism of Entrectinib can be increased when combined with Topotecan.
Golimumab Injection Golimumab Injection The metabolism of Entrectinib can be increased when combined with Golimumab.
Pazopanib Pazopanib The serum concentration of Entrectinib can be increased when it is combined with Pazopanib.
Asenapine Asenapine The risk or severity of QTc prolongation can be increased when Asenapine is combined with Entrectinib.
Albendazole Albendazole The metabolism of Entrectinib can be decreased when combined with Albendazole.
Tocilizumab Injection Tocilizumab Injection The metabolism of Entrectinib can be increased when combined with Tocilizumab.
Fingolimod Fingolimod The risk or severity of QTc prolongation can be increased when Fingolimod is combined with Entrectinib.
Eribulin Injection Eribulin Injection The risk or severity of QTc prolongation can be increased when Eribulin is combined with Entrectinib.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Entrectinib can be increased when it is combined with Cabazitaxel.
Lurasidone Lurasidone The risk or severity of QTc prolongation can be increased when Lurasidone is combined with Entrectinib.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be increased when combined with Entrectinib.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Entrectinib can be decreased when combined with Aldesleukin.
Terbutaline Injection Terbutaline Injection The risk or severity of QTc prolongation can be increased when Terbutaline is combined with Entrectinib.
Roflumilast Roflumilast The metabolism of Entrectinib can be decreased when combined with Roflumilast.
Linagliptin Linagliptin The metabolism of Entrectinib can be decreased when combined with Linagliptin.
Rilpivirine Rilpivirine The risk or severity of QTc prolongation can be increased when Rilpivirine is combined with Entrectinib.
Telaprevir Telaprevir The metabolism of Glecaprevir can be decreased when combined with Entrectinib.
Potassium Iodide Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Entrectinib.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Entrectinib can be increased when combined with Cyclophosphamide.
Triptorelin Injection Triptorelin Injection The risk or severity of QTc prolongation can be increased when Triptorelin is combined with Entrectinib.
Rivaroxaban Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Entrectinib.
Ticagrelor Ticagrelor The metabolism of Entrectinib can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Entrectinib can be increased when it is combined with Brentuximab vedotin.
Vandetanib Vandetanib The risk or severity of QTc prolongation can be increased when Vandetanib is combined with Entrectinib.
Clobazam Clobazam The metabolism of Entrectinib can be increased when combined with Clobazam.
Vemurafenib Vemurafenib The metabolism of Entrectinib can be increased when combined with Vemurafenib.
Ivacaftor Ivacaftor The metabolism of Entrectinib can be decreased when combined with Ivacaftor.
Axitinib Axitinib The serum concentration of Axitinib can be increased when it is combined with Entrectinib.
Crizotinib Crizotinib The metabolism of Entrectinib can be decreased when combined with Crizotinib.
Cabergoline Cabergoline The metabolism of Entrectinib can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Entrectinib can be decreased when combined with Naloxone.
Ambrisentan Ambrisentan The serum concentration of Ambrisentan can be increased when it is combined with Entrectinib.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Entrectinib.
Enzalutamide Enzalutamide The metabolism of Entrectinib can be increased when combined with Enzalutamide.
Mirabegron Mirabegron The risk or severity of QTc prolongation can be increased when Mirabegron is combined with Entrectinib.
Regorafenib Regorafenib The metabolism of Entrectinib can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The serum concentration of Entrectinib can be increased when it is combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Entrectinib can be increased when combined with Corticotropin.
Bedaquiline Bedaquiline The risk or severity of QTc prolongation can be increased when Bedaquiline is combined with Entrectinib.
Pomalidomide Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Entrectinib.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Entrectinib can be decreased when combined with Trastuzumab emtansine.
Apixaban Apixaban The serum concentration of Apixaban can be increased when it is combined with Entrectinib.
Canagliflozin Canagliflozin The serum concentration of Entrectinib can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The metabolism of Entrectinib can be increased when combined with Dabrafenib.
Trametinib Trametinib The metabolism of Entrectinib can be increased when combined with Trametinib.
Dolutegravir Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Entrectinib.
Afatinib Afatinib The serum concentration of Afatinib can be increased when it is combined with Entrectinib.
Perampanel Perampanel The metabolism of Entrectinib can be increased when combined with Perampanel.
Lomitapide Lomitapide The metabolism of Entrectinib can be decreased when combined with Lomitapide.
Simeprevir Simeprevir The metabolism of Entrectinib can be decreased when combined with Simeprevir.
Sofosbuvir Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Entrectinib.
Apremilast Apremilast The metabolism of Entrectinib can be increased when combined with Apremilast.
Ceritinib Ceritinib The risk or severity of QTc prolongation can be increased when Ceritinib is combined with Entrectinib.
Siltuximab Injection Siltuximab Injection The metabolism of Entrectinib can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Entrectinib can be increased when combined with Eslicarbazepine.
Belinostat Injection Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Entrectinib.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Entrectinib.
Testosterone Injection Testosterone Injection The metabolism of Entrectinib can be increased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Entrectinib can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The metabolism of Entrectinib can be decreased when combined with Vorapaxar.
Suvorexant Suvorexant The metabolism of Entrectinib can be decreased when combined with Suvorexant.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Entrectinib.
Olaparib Olaparib The metabolism of Entrectinib can be decreased when combined with Olaparib.
Tasimelteon Tasimelteon The metabolism of Entrectinib can be decreased when combined with Tasimelteon.
Lanreotide Injection Lanreotide Injection The metabolism of Entrectinib can be decreased when combined with Lanreotide.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Entrectinib.
Secukinumab Injection Secukinumab Injection The metabolism of Entrectinib can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of QTc prolongation can be increased when Risperidone is combined with Entrectinib.
Palbociclib Palbociclib The metabolism of Entrectinib can be decreased when combined with Palbociclib.
Lenvatinib Lenvatinib The risk or severity of QTc prolongation can be increased when Lenvatinib is combined with Entrectinib.
Naloxegol Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Entrectinib.
Panobinostat Panobinostat The risk or severity of QTc prolongation can be increased when Panobinostat is combined with Entrectinib.
Haloperidol Injection Haloperidol Injection The metabolism of Entrectinib can be decreased when combined with Haloperidol.
Ivabradine Ivabradine The risk or severity of QTc prolongation can be increased when Ivabradine is combined with Entrectinib.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Entrectinib can be increased when combined with Isavuconazonium.
Prednisolone Prednisolone The metabolism of Entrectinib can be increased when combined with Prednisolone.
Ziprasidone Injection Ziprasidone Injection The metabolism of Entrectinib can be decreased when combined with Ziprasidone.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Entrectinib.
Osimertinib Osimertinib The metabolism of Entrectinib can be increased when combined with Osimertinib.
Rifapentine Rifapentine The metabolism of Entrectinib can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Entrectinib can be increased when combined with Lesinurad.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Entrectinib can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Entrectinib can be increased when combined with Dexamethasone.
Venetoclax Venetoclax The metabolism of Entrectinib can be decreased when combined with Venetoclax.
Cobicistat Cobicistat The metabolism of Entrectinib can be decreased when combined with Cobicistat.
Selexipag Selexipag The serum concentration of Selexipag can be increased when it is combined with Entrectinib.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of QTc prolongation can be increased when Diphenhydramine is combined with Entrectinib.
Rucaparib Rucaparib The metabolism of Entrectinib can be decreased when combined with Rucaparib.
Ribociclib Ribociclib The metabolism of Entrectinib can be decreased when combined with Ribociclib.
Parathyroid Hormone Injection Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Entrectinib.
Brigatinib Brigatinib The metabolism of Entrectinib can be increased when combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) The risk or severity of QTc prolongation can be increased when Doxepin is combined with Entrectinib.
Deutetrabenazine Deutetrabenazine The risk or severity of QTc prolongation can be increased when Deutetrabenazine is combined with Entrectinib.
Deflazacort Deflazacort The metabolism of Entrectinib can be increased when combined with Deflazacort.
Sarilumab Injection Sarilumab Injection The metabolism of Entrectinib can be increased when combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Entrectinib can be increased when combined with Midostaurin.
Abaloparatide Injection Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Entrectinib.
Enasidenib Enasidenib The metabolism of Entrectinib can be increased when combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Entrectinib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Entrectinib can be increased when combined with Fosaprepitant.
Copanlisib Injection Copanlisib Injection The serum concentration of Copanlisib can be increased when it is combined with Entrectinib.
Delafloxacin Delafloxacin The risk or severity of QTc prolongation can be increased when Delafloxacin is combined with Entrectinib.
Abemaciclib Abemaciclib The serum concentration of Abemaciclib can be increased when it is combined with Entrectinib.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Entrectinib.
Acalabrutinib Acalabrutinib The metabolism of Entrectinib can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Entrectinib can be decreased when combined with Letermovir.
Tetrabenazine Tetrabenazine The risk or severity of QTc prolongation can be increased when Tetrabenazine is combined with Entrectinib.
Ertugliflozin Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Entrectinib.
Buprenorphine Injection Buprenorphine Injection The metabolism of Entrectinib can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The metabolism of Entrectinib can be increased when combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Entrectinib can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Entrectinib.
Baricitinib Baricitinib The serum concentration of Baricitinib can be increased when it is combined with Entrectinib.
Lofexidine Lofexidine The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Entrectinib.
Eliglustat Eliglustat The risk or severity of QTc prolongation can be increased when Eliglustat is combined with Entrectinib.
Encorafenib Encorafenib The risk or severity of QTc prolongation can be increased when Encorafenib is combined with Entrectinib.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Entrectinib.
Ivosidenib Ivosidenib The metabolism of Entrectinib can be increased when combined with Ivosidenib.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Entrectinib.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Entrectinib.
Dacomitinib Dacomitinib The serum concentration of Entrectinib can be increased when it is combined with Dacomitinib.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Entrectinib.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Entrectinib.
Stiripentol Stiripentol The metabolism of Entrectinib can be decreased when combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Entrectinib.
Gilteritinib Gilteritinib The risk or severity of QTc prolongation can be increased when Gilteritinib is combined with Entrectinib.
Glasdegib Glasdegib The risk or severity of QTc prolongation can be increased when Glasdegib is combined with Entrectinib.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Entrectinib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Entrectinib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Entrectinib can be increased when combined with Paclitaxel.
Rifamycin Rifamycin The metabolism of Entrectinib can be increased when combined with Rifamycin.
Prucalopride Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Entrectinib.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Entrectinib can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Entrectinib can be decreased when combined with Siponimod.
Alpelisib Alpelisib The metabolism of Entrectinib can be increased when combined with Alpelisib.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Entrectinib.
Triclabendazole Triclabendazole The risk or severity of QTc prolongation can be increased when Triclabendazole is combined with Entrectinib.
Pitolisant Pitolisant The metabolism of Entrectinib can be increased when combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Entrectinib.
Lefamulin Lefamulin Entrectinib may increase the QTc-prolonging activities of Lefamulin.
Phenytoin Injection Phenytoin Injection The metabolism of Entrectinib can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Entrectinib can be increased when combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Entrectinib.
Voxelotor Voxelotor The serum concentration of Entrectinib can be increased when it is combined with Voxelotor.
Lasmiditan Lasmiditan The serum concentration of Lasmiditan can be increased when it is combined with Entrectinib.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Entrectinib.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Entrectinib.
Cenobamate Cenobamate The metabolism of Entrectinib can be increased when combined with Cenobamate.
Selumetinib Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Entrectinib.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Entrectinib.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Entrectinib.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Entrectinib.
Ripretinib Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Entrectinib.
Selpercatinib Selpercatinib The risk or severity of QTc prolongation can be increased when Selpercatinib is combined with Entrectinib.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Entrectinib.
Fostemsavir Fostemsavir The serum concentration of Fostemsavir can be increased when it is combined with Entrectinib.
Octreotide Octreotide The risk or severity of QTc prolongation can be increased when Octreotide is combined with Entrectinib.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Entrectinib.
Pralsetinib Pralsetinib The metabolism of Pralsetinib can be increased when combined with Entrectinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Entrectinib can be decreased when it is combined with Satralizumab.
Relugolix Relugolix The serum concentration of Relugolix can be increased when it is combined with Entrectinib.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Entrectinib can be decreased when combined with Drospirenone.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Entrectinib can be increased when combined with Vitamin E.
Trazodone Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Entrectinib.
Phenobarbital Phenobarbital The metabolism of Entrectinib can be increased when combined with Phenobarbital.
Primidone Primidone The metabolism of Entrectinib can be increased when combined with Primidone.
Methsuximide Methsuximide The risk or severity of QTc prolongation can be increased when Methsuximide is combined with Entrectinib.
Chlorpromazine Chlorpromazine The metabolism of Entrectinib can be increased when combined with Chlorpromazine.
Diazepam Diazepam The metabolism of Entrectinib can be decreased when combined with Diazepam.
Lorazepam Lorazepam The metabolism of Entrectinib can be decreased when combined with Lorazepam.
Amantadine Amantadine The risk or severity of QTc prolongation can be increased when Amantadine is combined with Entrectinib.
Bromocriptine Bromocriptine The metabolism of Entrectinib can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Entrectinib can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Entrectinib can be decreased when combined with Phenelzine.
Tetracycline Tetracycline The metabolism of Entrectinib can be decreased when combined with Tetracycline.
Prochlorperazine Prochlorperazine The risk or severity of QTc prolongation can be increased when Prochlorperazine is combined with Entrectinib.
Thioridazine Thioridazine The risk or severity of QTc prolongation can be increased when Thioridazine is combined with Entrectinib.
Methadone Methadone The metabolism of Entrectinib can be increased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Entrectinib can be decreased when combined with Oxybutynin.
Benztropine Benztropine The risk or severity of QTc prolongation can be increased when Benzatropine is combined with Entrectinib.
Maprotiline Maprotiline The risk or severity of QTc prolongation can be increased when Maprotiline is combined with Entrectinib.
Orphenadrine Orphenadrine The risk or severity of QTc prolongation can be increased when Orphenadrine is combined with Entrectinib.
Phentermine Phentermine The metabolism of Entrectinib can be decreased when combined with Phentermine.
Amoxapine Amoxapine The risk or severity of QTc prolongation can be increased when Amoxapine is combined with Entrectinib.
Hydrocortisone Hydrocortisone The metabolism of Entrectinib can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The serum concentration of Entrectinib can be increased when it is combined with Doxorubicin.
Dactinomycin Dactinomycin The serum concentration of Entrectinib can be increased when it is combined with Dactinomycin.
Carbamazepine Carbamazepine The metabolism of Entrectinib can be increased when combined with Carbamazepine.
Hydralazine Hydralazine The metabolism of Entrectinib can be decreased when combined with Hydralazine.
Cimetidine Cimetidine The metabolism of Entrectinib can be decreased when combined with Cimetidine.
Warfarin Warfarin The metabolism of Entrectinib can be increased when combined with Warfarin.
Loperamide Loperamide The metabolism of Entrectinib can be decreased when combined with Loperamide.
Promethazine Promethazine The risk or severity of QTc prolongation can be increased when Promethazine is combined with Entrectinib.
Daunorubicin Daunorubicin The metabolism of Entrectinib can be decreased when combined with Daunorubicin.
Griseofulvin Griseofulvin The metabolism of Entrectinib can be increased when combined with Griseofulvin.
Digoxin Digoxin The risk or severity of QTc prolongation can be increased when Digoxin is combined with Entrectinib.
Chloroquine Chloroquine The risk or severity of QTc prolongation can be increased when Chloroquine is combined with Entrectinib.
Quinine Quinine The metabolism of Entrectinib can be increased when combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of QTc prolongation can be increased when Ethosuximide is combined with Entrectinib.
Calcitriol Calcitriol The metabolism of Entrectinib can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Entrectinib can be increased when combined with Sulfinpyrazone.
Secobarbital Secobarbital The metabolism of Entrectinib can be increased when combined with Secobarbital.
Desipramine Desipramine The risk or severity of QTc prolongation can be increased when Desipramine is combined with Entrectinib.
Amitriptyline Amitriptyline The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Entrectinib.
Imipramine Imipramine The risk or severity of QTc prolongation can be increased when Imipramine is combined with Entrectinib.
Probenecid Probenecid The metabolism of Entrectinib can be increased when combined with Probenecid.
Quinidine Quinidine The risk or severity of QTc prolongation can be increased when Quinidine is combined with Entrectinib.
Procainamide Procainamide The risk or severity of QTc prolongation can be increased when Procainamide is combined with Entrectinib.
Isoniazid Isoniazid The metabolism of Entrectinib can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Entrectinib can be increased when combined with Rifampicin.
Disopyramide Disopyramide The risk or severity of QTc prolongation can be increased when Disopyramide is combined with Entrectinib.
Valproic Acid Valproic Acid The risk or severity of QTc prolongation can be increased when Valproic acid is combined with Entrectinib.
Tamoxifen Tamoxifen The metabolism of Entrectinib can be increased when combined with Tamoxifen.
Levothyroxine Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Entrectinib.
Liothyronine Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Entrectinib.
Methimazole Methimazole The metabolism of Methimazole can be decreased when combined with Entrectinib.
Propylthiouracil Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Entrectinib.
Niacin Niacin The metabolism of Entrectinib can be decreased when combined with Niacin.
Doxylamine Doxylamine The risk or severity of QTc prolongation can be increased when Doxylamine is combined with Entrectinib.
Cyproheptadine Cyproheptadine The risk or severity of QTc prolongation can be increased when Cyproheptadine is combined with Entrectinib.
Clemastine Clemastine The risk or severity of QTc prolongation can be increased when Clemastine is combined with Entrectinib.
Chlorpheniramine Chlorpheniramine The risk or severity of QTc prolongation can be increased when Chlorpheniramine is combined with Entrectinib.
Brompheniramine Brompheniramine The risk or severity of QTc prolongation can be increased when Dexbrompheniramine is combined with Entrectinib.
Hydrochlorothiazide Hydrochlorothiazide The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Entrectinib.
Danazol Danazol The metabolism of Entrectinib can be decreased when combined with Danazol.
Disulfiram Disulfiram The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Entrectinib.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The risk or severity of QTc prolongation can be increased when Propranolol is combined with Entrectinib.
Nortriptyline Nortriptyline The risk or severity of QTc prolongation can be increased when Nortriptyline is combined with Entrectinib.
Amphotericin B Injection Amphotericin B Injection The metabolism of Entrectinib can be decreased when combined with Amphotericin B.
Oxytocin Injection Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Entrectinib.
Clomiphene Clomiphene The serum concentration of Clomifene can be increased when it is combined with Entrectinib.
Papaverine Papaverine The risk or severity of QTc prolongation can be increased when Papaverine is combined with Entrectinib.
Fluorouracil Injection Fluorouracil Injection The risk or severity of QTc prolongation can be increased when Fluorouracil is combined with Entrectinib.
Colchicine Colchicine The metabolism of Entrectinib can be increased when combined with Colchicine.
Cephalexin Cephalexin The metabolism of Entrectinib can be decreased when combined with Cephalexin.
Acetazolamide Acetazolamide The metabolism of Entrectinib can be decreased when combined with Acetazolamide.
Calcitonin Salmon Injection Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Entrectinib.
Ketoconazole Ketoconazole The metabolism of Entrectinib can be decreased when combined with Ketoconazole.
Vincristine Injection Vincristine Injection The excretion of Entrectinib can be decreased when combined with Vincristine.
Vinblastine Vinblastine The metabolism of Entrectinib can be increased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Entrectinib can be decreased when combined with Metoprolol.
Hydroxyzine Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Entrectinib.
Thiothixene Thiothixene The risk or severity of QTc prolongation can be increased when Thiothixene is combined with Entrectinib.
Hyoscyamine Hyoscyamine The risk or severity of QTc prolongation can be increased when Hyoscyamine is combined with Entrectinib.
Diltiazem Diltiazem The metabolism of Entrectinib can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Entrectinib can be increased when combined with Nifedipine.
Timolol Timolol The risk or severity of QTc prolongation can be increased when Timolol is combined with Entrectinib.
Verapamil Verapamil The metabolism of Entrectinib can be decreased when combined with Verapamil.
Etoposide Etoposide The metabolism of Entrectinib can be increased when combined with Etoposide.
Glyburide Glyburide The metabolism of Entrectinib can be decreased when combined with Glyburide.
Indapamide Indapamide The risk or severity of QTc prolongation can be increased when Indapamide is combined with Entrectinib.
Dicloxacillin Dicloxacillin The metabolism of Entrectinib can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Entrectinib can be increased when combined with Nafcillin.
Pentamidine Injection Pentamidine Injection The risk or severity of QTc prolongation can be increased when Pentamidine is combined with Entrectinib.
Leuprolide Injection Leuprolide Injection The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Entrectinib.
Pimozide Pimozide The risk or severity of QTc prolongation can be increased when Pimozide is combined with Entrectinib.
Amiodarone Amiodarone The risk or severity of QTc prolongation can be increased when Amiodarone is combined with Entrectinib.
Lovastatin Lovastatin The metabolism of Entrectinib can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Entrectinib can be decreased when combined with Ciprofloxacin.
Fluoxetine Fluoxetine The risk or severity of QTc prolongation can be increased when Fluoxetine is combined with Entrectinib.
Nimodipine Nimodipine The risk or severity of QTc prolongation can be increased when Nimodipine is combined with Entrectinib.
Clozapine Clozapine The metabolism of Entrectinib can be increased when combined with Clozapine.
Ofloxacin Ofloxacin The risk or severity of QTc prolongation can be increased when Ofloxacin is combined with Entrectinib.
Clarithromycin Clarithromycin The metabolism of Entrectinib can be decreased when combined with Clarithromycin.
Felodipine Felodipine The risk or severity of QTc prolongation can be increased when Felodipine is combined with Entrectinib.
Pravastatin Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Entrectinib.
Simvastatin Simvastatin The serum concentration of Entrectinib can be increased when it is combined with Simvastatin.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Entrectinib.
Amlodipine Amlodipine The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Entrectinib.
Teniposide Injection Teniposide Injection The metabolism of Entrectinib can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Entrectinib can be decreased when combined with Itraconazole.
Rifabutin Rifabutin The metabolism of Entrectinib can be increased when combined with Rifabutin.
Sotalol Sotalol The risk or severity of QTc prolongation can be increased when Sotalol is combined with Entrectinib.
Bisoprolol Bisoprolol The serum concentration of Entrectinib can be increased when it is combined with Bisoprolol.
Doxazosin Doxazosin The metabolism of Entrectinib can be decreased when combined with Doxazosin.
Isradipine Isradipine The metabolism of Entrectinib can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Entrectinib can be increased when combined with Omeprazole.
Cisapride Cisapride The risk or severity of QTc prolongation can be increased when Cisapride is combined with Entrectinib.
Fluvastatin Fluvastatin The metabolism of Entrectinib can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The risk or severity of QTc prolongation can be increased when Venlafaxine is combined with Entrectinib.
Famciclovir Famciclovir The metabolism of Entrectinib can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine The metabolism of Entrectinib can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Entrectinib can be decreased when combined with Nefazodone.
Lamotrigine Lamotrigine The risk or severity of QTc prolongation can be increased when Lamotrigine is combined with Entrectinib.
Losartan Losartan The risk or severity of QTc prolongation can be increased when Losartan is combined with Entrectinib.
Moexipril Moexipril The risk or severity of QTc prolongation can be increased when Moexipril is combined with Entrectinib.
Lansoprazole Lansoprazole The metabolism of Entrectinib can be increased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Entrectinib can be increased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Entrectinib can be decreased when combined with Nicardipine.
Ticlopidine Ticlopidine The metabolism of Entrectinib can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Entrectinib can be decreased when combined with Saquinavir.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Entrectinib.
Ritonavir Ritonavir The metabolism of Entrectinib can be decreased when combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Entrectinib can be decreased when combined with Docetaxel.
Clomipramine Clomipramine The risk or severity of QTc prolongation can be increased when Clomipramine is combined with Entrectinib.
Zafirlukast Zafirlukast The metabolism of Entrectinib can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The risk or severity of QTc prolongation can be increased when Mirtazapine is combined with Entrectinib.
Topiramate Topiramate The metabolism of Entrectinib can be increased when combined with Topiramate.
Donepezil Donepezil The risk or severity of QTc prolongation can be increased when Donepezil is combined with Entrectinib.
Nelfinavir Nelfinavir The risk or severity of QTc prolongation can be increased when Nelfinavir is combined with Entrectinib.
Fexofenadine Fexofenadine The serum concentration of Fexofenadine can be increased when it is combined with Entrectinib.
Azithromycin Azithromycin The risk or severity of QTc prolongation can be increased when Azithromycin is combined with Entrectinib.
Loratadine Loratadine The risk or severity of QTc prolongation can be increased when Loratadine is combined with Entrectinib.
Bicalutamide Bicalutamide The metabolism of Entrectinib can be decreased when combined with Bicalutamide.
Sertraline Sertraline The risk or severity of QTc prolongation can be increased when Sertraline is combined with Entrectinib.
Propafenone Propafenone The risk or severity of QTc prolongation can be increased when Propafenone is combined with Entrectinib.
Raloxifene Raloxifene The metabolism of Entrectinib can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Entrectinib can be decreased when combined with Irbesartan.
Quetiapine Quetiapine The risk or severity of QTc prolongation can be increased when Quetiapine is combined with Entrectinib.
Cetirizine Cetirizine The risk or severity of QTc prolongation can be increased when Cetirizine is combined with Entrectinib.
Paroxetine Paroxetine The metabolism of Entrectinib can be decreased when combined with Paroxetine.
Citalopram Citalopram The risk or severity of QTc prolongation can be increased when Citalopram is combined with Entrectinib.
Efavirenz Efavirenz The metabolism of Entrectinib can be increased when combined with Efavirenz.
Sildenafil Sildenafil The serum concentration of Sildenafil can be increased when it is combined with Entrectinib.
Tolterodine Tolterodine The risk or severity of QTc prolongation can be increased when Tolterodine is combined with Entrectinib.
Galantamine Galantamine The risk or severity of QTc prolongation can be increased when Galantamine is combined with Entrectinib.
Rabeprazole Rabeprazole The metabolism of Entrectinib can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Entrectinib can be increased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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