Nintedanib

Generic name: Pronounced as (nin ted' a nib )
Brand names
  • Ofev®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 05/15/2020

Nintedanib is used to treat idiopathic pulmonary fibrosis (IPF; scarring of the lungs with an unknown cause). It is also used to treat certain types of chronic fibrosing interstitial lung diseases (ILD; an ongoing disease in which there is increased scarring of the lungs). Nintedanib is also used to slow the rate of decline in lung function in people with systemic sclerosis-associated interstitial lung disease (SSc-ILD; also known as scleroderma-associated ILD: a disease in which there is scarring of the lungs that is often fatal). Nintedanib is in a class of medications called kinase inhibitors. It works by blocking the action of enzymes involved in causing fibrosis.

Nintedanib comes as a capsule to take by mouth. It is usually taken with food every 12 hours (twice a day). Take nintedanib capsules at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take nintedanib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole with liquid; do not chew or crush them.

Your doctor may need to decrease your dose or stop treatment if you experience certain severe side effects. Be sure to tell your doctor how you are feeling during your treatment.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking nintedanib,

  • tell your doctor and pharmacist if you are allergic to nintedanib, any other medications, or any of the ingredients in nintedanib capsules. Ask your pharmacist or check the manufacturer's patient information for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: anticoagulants (''blood thinners'') such as warfarin (Coumadin, Jantoven); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen (Advil, Motrin, others) and naproxen (Aleve, Anaprox, Naprelan); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); erythromycin (E.E.S., Ery-Tab, Eryc); ketoconazole; laxatives; oral steroids such as dexamethasone (Decadron, Dexpak), methylprednisolone (Medrol), and prednisone; phenytoin (Dilantin, Phenytek); pirfenidone (Esbriet); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); or stool softeners. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you or anyone in your family has ever had a bleeding problem, if you have or have ever had liver or heart disease, diverticular disease (diverticulitis; small pouches in the lining of the large intestine that can become inflamed), or blood clots, and if you have had recent abdominal surgery.

  • tell your doctor if you are pregnant, plan to become pregnant, or can possibly become pregnant. You should not start taking nintedanib until a pregnancy test has shown that you are not pregnant. You should not become pregnant while you are taking nintedanib; the medication may harm your unborn baby. Nintedanib may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, implants, or injections), so you should not use these as your only method of birth control. You must also use a barrier method of birth control (device that blocks sperm from entering the uterus such as a condom or a diaphragm). Talk to your doctor about birth control methods that you can use during your treatment and for at least 3 months after your last dose of nintedanib. If you become pregnant while taking nintedanib, call your doctor immediately.

  • tell your doctor if you are breastfeeding.

  • tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this medication. You should stop smoking before you start taking nintedanib and avoid smoking during your treatment.

Unless your doctor tells you otherwise, continue your normal diet.

If you miss a dose of nintedanib, skip the missed dose and continue your regular schedule. Do not take a double dose to make up for a missed one.

  • Nintedanib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • decreased appetite

    • weight loss

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

    • diarrhea

    • extreme tiredness

    • unusual bleeding or bruising

    • lack of energy

    • loss of appetite

    • pain in the upper right part of the stomach

    • yellowing of the skin or eyes

    • dark or brown (tea-colored) urine

    • chest pain

    • pain in your arms, back, neck, or jaw

    • shortness of breath

    • numbness or weakness on one side of your body

    • difficulty speaking

    • headache

    • dizziness

    • wounds that do not heal

    • pain or swelling in your stomach area, nausea, vomiting, fever, chills, or blood in your stool

    • rash

    • itching

  • Nintedanib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before and during your treatment to check your body's response to nintedanib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Delavirdine Delavirdine The metabolism of Nintedanib can be decreased when combined with Delavirdine.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Nintedanib.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The serum concentration of Nintedanib can be increased when it is combined with Erythromycin.
Fenofibrate Fenofibrate The metabolism of Nintedanib can be decreased when combined with Fenofibrate.
Methylergonovine Methylergonovine The metabolism of Nintedanib can be decreased when combined with Methylergometrine.
Paregoric Paregoric The serum concentration of Nintedanib can be increased when it is combined with Morphine.
Reserpine Reserpine The serum concentration of Nintedanib can be increased when it is combined with Reserpine.
Tacrolimus Tacrolimus The metabolism of Tacrolimus can be decreased when combined with Nintedanib.
Triamcinolone Triamcinolone The metabolism of Nintedanib can be increased when combined with Triamcinolone.
Doxycycline Injection Doxycycline Injection The metabolism of Nintedanib can be decreased when combined with Doxycycline.
Fluconazole Injection Fluconazole Injection The serum concentration of Nintedanib can be increased when it is combined with Fluconazole.
Meperidine Injection Meperidine Injection The metabolism of Nintedanib can be increased when combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Nintedanib can be increased when combined with Methylprednisolone.
Metronidazole Injection Metronidazole Injection The metabolism of Nintedanib can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The serum concentration of Nintedanib can be increased when it is combined with Morphine.
Zidovudine Injection Zidovudine Injection The metabolism of Nintedanib can be increased when combined with Zidovudine.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Nintedanib.
Enoxaparin Injection Enoxaparin Injection The risk or severity of bleeding can be increased when Enoxaparin is combined with Nintedanib.
Dofetilide Dofetilide The metabolism of Dofetilide can be decreased when combined with Nintedanib.
Orlistat Orlistat The metabolism of Nintedanib can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Nintedanib can be increased when combined with Oxcarbazepine.
Anakinra Anakinra The metabolism of Nintedanib can be increased when combined with Anakinra.
Pentosan Polysulfate Pentosan Polysulfate The risk or severity of bleeding can be increased when Pentosan polysulfate is combined with Nintedanib.
Trimipramine Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Nintedanib.
Etanercept Injection Etanercept Injection The metabolism of Nintedanib can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Nintedanib can be increased when combined with Modafinil.
Tenofovir Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Nintedanib.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Nintedanib.
Epinephrine Injection Epinephrine Injection The metabolism of Nintedanib can be decreased when combined with Epinephrine.
Zonisamide Zonisamide The serum concentration of Nintedanib can be increased when it is combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Nintedanib can be increased when combined with Adalimumab.
Teriparatide Injection Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Nintedanib.
Atazanavir Atazanavir The metabolism of Nintedanib can be decreased when combined with Atazanavir.
Mefloquine Mefloquine The metabolism of Nintedanib can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Nintedanib can be decreased when combined with Rosuvastatin.
Vardenafil Vardenafil The serum concentration of Nintedanib can be increased when it is combined with Vardenafil.
Aprepitant Aprepitant The metabolism of Nintedanib can be decreased when combined with Aprepitant.
Tegaserod Tegaserod The serum concentration of Nintedanib can be increased when it is combined with Tegaserod.
Progesterone Progesterone The metabolism of Nintedanib can be increased when combined with Progesterone.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Nintedanib.
Infliximab Injection Infliximab Injection The metabolism of Nintedanib can be increased when combined with Infliximab.
Rifaximin Rifaximin The metabolism of Nintedanib can be increased when combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Nintedanib can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Nintedanib can be decreased when combined with Norethisterone.
Bosentan Bosentan The metabolism of Nintedanib can be increased when combined with Bosentan.
Erlotinib Erlotinib The metabolism of Nintedanib can be decreased when combined with Erlotinib.
Voriconazole Voriconazole The metabolism of Nintedanib can be decreased when combined with Voriconazole.
Deferasirox Deferasirox The metabolism of Nintedanib can be increased when combined with Deferasirox.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Nintedanib.
Felbamate Felbamate The metabolism of Nintedanib can be increased when combined with Felbamate.
Ranolazine Ranolazine The serum concentration of Nintedanib can be increased when it is combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Nintedanib can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Nintedanib can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The serum concentration of Nintedanib can be increased when it is combined with Sitagliptin.
Gefitinib Gefitinib The metabolism of Nintedanib can be decreased when combined with Gefitinib.
Paliperidone Paliperidone The serum concentration of Nintedanib can be increased when it is combined with Paliperidone.
Bortezomib Bortezomib The metabolism of Bortezomib can be decreased when combined with Nintedanib.
Posaconazole Posaconazole The metabolism of Nintedanib can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Nintedanib can be decreased when combined with Primaquine.
Darunavir Darunavir The metabolism of Darunavir can be decreased when combined with Nintedanib.
Sorafenib Sorafenib The metabolism of Nintedanib can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Nintedanib can be decreased when combined with Sunitinib.
Lapatinib Lapatinib The serum concentration of Nintedanib can be increased when it is combined with Lapatinib.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Nintedanib.
Armodafinil Armodafinil The metabolism of Nintedanib can be increased when combined with Armodafinil.
Ivermectin Ivermectin The metabolism of Nintedanib can be increased when combined with Ivermectin.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Nintedanib.
Nilotinib Nilotinib The metabolism of Nintedanib can be decreased when combined with Nilotinib.
Toremifene Toremifene The serum concentration of Nintedanib can be increased when it is combined with Toremifene.
Bexarotene Bexarotene The metabolism of Nintedanib can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Nintedanib can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Nintedanib can be decreased when combined with Chloramphenicol.
Etravirine Etravirine The metabolism of Nintedanib can be increased when combined with Etravirine.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Nintedanib can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The metabolism of Nintedanib can be decreased when combined with Desvenlafaxine.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Nintedanib.
Pilocarpine Pilocarpine The metabolism of Nintedanib can be decreased when combined with Pilocarpine.
Certolizumab Injection Certolizumab Injection The metabolism of Nintedanib can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Nintedanib.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Nintedanib.
Mitotane Mitotane The metabolism of Nintedanib can be increased when combined with Mitotane.
Rufinamide Rufinamide The metabolism of Nintedanib can be increased when combined with Rufinamide.
Silodosin Silodosin The serum concentration of Nintedanib can be increased when it is combined with Silodosin.
Midazolam Midazolam The metabolism of Nintedanib can be decreased when combined with Midazolam.
Eltrombopag Eltrombopag The metabolism of Nintedanib can be decreased when combined with Eltrombopag.
Milnacipran Milnacipran The metabolism of Nintedanib can be decreased when combined with Milnacipran.
Prasugrel Prasugrel The risk or severity of bleeding can be increased when Prasugrel is combined with Nintedanib.
Lacosamide Lacosamide The metabolism of Nintedanib can be decreased when combined with Lacosamide.
Everolimus Everolimus The metabolism of Everolimus can be decreased when combined with Nintedanib.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Nintedanib can be decreased when combined with Tolvaptan.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Nintedanib.
Romidepsin Injection Romidepsin Injection The metabolism of Nintedanib can be decreased when combined with Romidepsin.
Topotecan Topotecan The metabolism of Nintedanib can be decreased when combined with Topotecan.
Golimumab Injection Golimumab Injection The metabolism of Nintedanib can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Nintedanib can be decreased when combined with Pazopanib.
Albendazole Albendazole The metabolism of Nintedanib can be decreased when combined with Albendazole.
Dabigatran Dabigatran The risk or severity of bleeding can be increased when Dabigatran is combined with Nintedanib.
Tocilizumab Injection Tocilizumab Injection The metabolism of Nintedanib can be increased when combined with Tocilizumab.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Nintedanib can be decreased when combined with Cabazitaxel.
Acetaminophen Injection Acetaminophen Injection The serum concentration of Acetaminophen can be increased when it is combined with Nintedanib.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Nintedanib can be decreased when combined with Aldesleukin.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be decreased when combined with Nintedanib.
Roflumilast Roflumilast The metabolism of Nintedanib can be decreased when combined with Roflumilast.
Linagliptin Linagliptin The serum concentration of Nintedanib can be increased when it is combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Nintedanib can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The serum concentration of Nintedanib can be increased when it is combined with Glecaprevir.
Potassium Iodide Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Nintedanib.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Nintedanib can be decreased when combined with Cyclophosphamide.
Rivaroxaban Rivaroxaban The risk or severity of bleeding can be increased when Rivaroxaban is combined with Nintedanib.
Ticagrelor Ticagrelor The risk or severity of bleeding can be increased when Ticagrelor is combined with Nintedanib.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Nintedanib can be decreased when combined with Brentuximab vedotin.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Nintedanib.
Vandetanib Vandetanib The metabolism of Nintedanib can be decreased when combined with Vandetanib.
Clobazam Clobazam The serum concentration of Nintedanib can be increased when it is combined with Clobazam.
Vemurafenib Vemurafenib The serum concentration of Nintedanib can be increased when it is combined with Vemurafenib.
Ivacaftor Ivacaftor The serum concentration of Nintedanib can be increased when it is combined with Ivacaftor.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Nintedanib.
Crizotinib Crizotinib The metabolism of Nintedanib can be decreased when combined with Crizotinib.
Cabergoline Cabergoline The metabolism of Nintedanib can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Nintedanib can be decreased when combined with Naloxone.
Ambrisentan Ambrisentan The serum concentration of Nintedanib can be increased when it is combined with Ambrisentan.
Fondaparinux Injection Fondaparinux Injection The risk or severity of bleeding can be increased when Fondaparinux is combined with Nintedanib.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Nintedanib can be increased when it is combined with Carfilzomib.
Iloprost Iloprost The risk or severity of bleeding can be increased when Iloprost is combined with Nintedanib.
Enzalutamide Enzalutamide The metabolism of Nintedanib can be increased when combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Nintedanib can be increased when it is combined with Mirabegron.
Regorafenib Regorafenib The metabolism of Nintedanib can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Nintedanib can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Nintedanib can be increased when combined with Corticotropin.
Ponatinib Ponatinib The metabolism of Nintedanib can be decreased when combined with Ponatinib.
Pomalidomide Pomalidomide The metabolism of Nintedanib can be decreased when combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Nintedanib can be decreased when combined with Trastuzumab emtansine.
Apixaban Apixaban The risk or severity of bleeding can be increased when Apixaban is combined with Nintedanib.
Canagliflozin Canagliflozin The serum concentration of Nintedanib can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The metabolism of Nintedanib can be decreased when combined with Dabrafenib.
Trametinib Trametinib The metabolism of Nintedanib can be increased when combined with Trametinib.
Dolutegravir Dolutegravir The serum concentration of Nintedanib can be increased when it is combined with Dolutegravir.
Afatinib Afatinib The serum concentration of Nintedanib can be increased when it is combined with Afatinib.
Perampanel Perampanel The metabolism of Nintedanib can be increased when combined with Perampanel.
Lomitapide Lomitapide The metabolism of Nintedanib can be decreased when combined with Lomitapide.
Simeprevir Simeprevir The serum concentration of Nintedanib can be increased when it is combined with Simeprevir.
Sofosbuvir Sofosbuvir The serum concentration of Nintedanib can be increased when it is combined with Sofosbuvir.
Apremilast Apremilast The metabolism of Nintedanib can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Nintedanib can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Nintedanib can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Nintedanib can be increased when combined with Eslicarbazepine.
Belinostat Injection Belinostat Injection The serum concentration of Nintedanib can be increased when it is combined with Belinostat.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Nintedanib.
Testosterone Injection Testosterone Injection The metabolism of Nintedanib can be increased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Nintedanib can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The risk or severity of bleeding can be increased when Vorapaxar is combined with Nintedanib.
Suvorexant Suvorexant The serum concentration of Nintedanib can be increased when it is combined with Suvorexant.
Edoxaban Edoxaban The risk or severity of bleeding can be increased when Edoxaban is combined with Nintedanib.
Olaparib Olaparib The metabolism of Nintedanib can be decreased when combined with Olaparib.
Tasimelteon Tasimelteon The metabolism of Nintedanib can be decreased when combined with Tasimelteon.
Lanreotide Injection Lanreotide Injection The metabolism of Nintedanib can be decreased when combined with Lanreotide.
Pirfenidone Pirfenidone The risk or severity of adverse effects can be increased when Pirfenidone is combined with Nintedanib.
Secukinumab Injection Secukinumab Injection The metabolism of Nintedanib can be increased when combined with Secukinumab.
Palbociclib Palbociclib The metabolism of Nintedanib can be decreased when combined with Palbociclib.
Lenvatinib Lenvatinib The serum concentration of Nintedanib can be increased when it is combined with Lenvatinib.
Panobinostat Panobinostat The metabolism of Nintedanib can be decreased when combined with Panobinostat.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Nintedanib.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Nintedanib can be increased when it is combined with Isavuconazonium.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Nintedanib.
Flibanserin Flibanserin The serum concentration of Nintedanib can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant The serum concentration of Nintedanib can be increased when it is combined with Rolapitant.
Prednisolone Prednisolone The metabolism of Nintedanib can be increased when combined with Prednisolone.
Daclatasvir Daclatasvir The serum concentration of Nintedanib can be increased when it is combined with Daclatasvir.
Ziprasidone Injection Ziprasidone Injection The metabolism of Nintedanib can be decreased when combined with Ziprasidone.
Cobimetinib Cobimetinib The metabolism of Nintedanib can be decreased when combined with Cobimetinib.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Nintedanib.
Osimertinib Osimertinib The metabolism of Osimertinib can be decreased when combined with Nintedanib.
Alectinib Alectinib The metabolism of Alectinib can be decreased when combined with Nintedanib.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Nintedanib.
Rifapentine Rifapentine The metabolism of Nintedanib can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Nintedanib can be increased when combined with Lesinurad.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Nintedanib can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Nintedanib can be increased when combined with Dexamethasone.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding can be increased when Defibrotide is combined with Nintedanib.
Venetoclax Venetoclax The metabolism of Nintedanib can be decreased when combined with Venetoclax.
Cobicistat Cobicistat The metabolism of Nintedanib can be decreased when combined with Cobicistat.
Selexipag Selexipag The serum concentration of Selexipag can be increased when it is combined with Nintedanib.
Rucaparib Rucaparib The serum concentration of Nintedanib can be increased when it is combined with Rucaparib.
Ribociclib Ribociclib The metabolism of Nintedanib can be decreased when combined with Ribociclib.
Parathyroid Hormone Injection Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Nintedanib.
Brigatinib Brigatinib The metabolism of Nintedanib can be decreased when combined with Brigatinib.
Deflazacort Deflazacort The metabolism of Nintedanib can be increased when combined with Deflazacort.
Sarilumab Injection Sarilumab Injection The metabolism of Nintedanib can be increased when combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Nintedanib can be increased when combined with Midostaurin.
Neratinib Neratinib The metabolism of Nintedanib can be decreased when combined with Neratinib.
Abaloparatide Injection Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Nintedanib.
Enasidenib Enasidenib The metabolism of Nintedanib can be decreased when combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Nintedanib can be increased when it is combined with Inotuzumab ozogamicin.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Nintedanib can be increased when combined with Fosaprepitant.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Nintedanib.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Nintedanib.
Betrixaban Betrixaban The risk or severity of bleeding can be increased when Betrixaban is combined with Nintedanib.
Acalabrutinib Acalabrutinib The metabolism of Nintedanib can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Nintedanib can be decreased when combined with Letermovir.
Ertugliflozin Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Nintedanib.
Buprenorphine Injection Buprenorphine Injection The metabolism of Nintedanib can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The serum concentration of Nintedanib can be decreased when it is combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Nintedanib can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Nintedanib.
Baricitinib Baricitinib The metabolism of Baricitinib can be decreased when combined with Nintedanib.
Eliglustat Eliglustat The serum concentration of Nintedanib can be increased when it is combined with Eliglustat.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Nintedanib.
Ivosidenib Ivosidenib The metabolism of Nintedanib can be decreased when combined with Ivosidenib.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Nintedanib.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Nintedanib.
Dacomitinib Dacomitinib The metabolism of Nintedanib can be decreased when combined with Dacomitinib.
Duvelisib Duvelisib The serum concentration of Duvelisib can be increased when it is combined with Nintedanib.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Nintedanib.
Sarecycline Sarecycline The serum concentration of Nintedanib can be increased when it is combined with Sarecycline.
Stiripentol Stiripentol The metabolism of Nintedanib can be decreased when combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Nintedanib.
Gilteritinib Gilteritinib The serum concentration of Gilteritinib can be increased when it is combined with Nintedanib.
Glasdegib Glasdegib The serum concentration of Nintedanib can be increased when it is combined with Glasdegib.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Nintedanib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Nintedanib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Nintedanib.
Rifamycin Rifamycin The metabolism of Nintedanib can be increased when combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Nintedanib can be decreased when combined with Prucalopride.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Nintedanib can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Nintedanib.
Erdafitinib Erdafitinib The serum concentration of Nintedanib can be increased when it is combined with Erdafitinib.
Alpelisib Alpelisib The metabolism of Nintedanib can be decreased when combined with Alpelisib.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Nintedanib.
Triclabendazole Triclabendazole The metabolism of Nintedanib can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The metabolism of Nintedanib can be decreased when combined with Entrectinib.
Pexidartinib Pexidartinib The metabolism of Nintedanib can be decreased when combined with Pexidartinib.
Istradefylline Istradefylline The serum concentration of Nintedanib can be increased when it is combined with Istradefylline.
Pitolisant Pitolisant The serum concentration of Nintedanib can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Nintedanib can be increased when it is combined with Fedratinib.
Lefamulin Lefamulin The metabolism of Lefamulin can be decreased when combined with Nintedanib.
Phenytoin Injection Phenytoin Injection The metabolism of Nintedanib can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Nintedanib can be increased when combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Nintedanib.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Nintedanib.
Lasmiditan Lasmiditan The serum concentration of Nintedanib can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Nintedanib.
Tazemetostat Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Nintedanib.
Cenobamate Cenobamate The serum concentration of Nintedanib can be decreased when it is combined with Cenobamate.
Selumetinib Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Nintedanib.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Nintedanib.
Tucatinib Tucatinib Nintedanib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Nintedanib.
Ripretinib Ripretinib The serum concentration of Nintedanib can be increased when it is combined with Ripretinib.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Nintedanib.
Fostemsavir Fostemsavir The serum concentration of Fostemsavir can be increased when it is combined with Nintedanib.
Octreotide Octreotide The metabolism of Nintedanib can be decreased when combined with Octreotide.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Nintedanib.
Pralsetinib Pralsetinib The serum concentration of Nintedanib can be increased when it is combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Nintedanib can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Nintedanib can be decreased when combined with Drospirenone.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Nintedanib can be increased when combined with Vitamin E.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Nintedanib.
Indomethacin Indomethacin The metabolism of Nintedanib can be decreased when combined with Indomethacin.
Phenobarbital Phenobarbital The metabolism of Nintedanib can be increased when combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Nintedanib.
Primidone Primidone The metabolism of Nintedanib can be increased when combined with Primidone.
Chlorpromazine Chlorpromazine The metabolism of Nintedanib can be increased when combined with Chlorpromazine.
Diazepam Diazepam The metabolism of Nintedanib can be decreased when combined with Diazepam.
Lorazepam Lorazepam The metabolism of Nintedanib can be decreased when combined with Lorazepam.
Bromocriptine Bromocriptine The metabolism of Nintedanib can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Nintedanib can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Nintedanib can be decreased when combined with Phenelzine.
Tetracycline Tetracycline The metabolism of Nintedanib can be decreased when combined with Tetracycline.
Prochlorperazine Prochlorperazine The metabolism of Nintedanib can be decreased when combined with Prochlorperazine.
Methadone Methadone The metabolism of Nintedanib can be increased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Nintedanib can be decreased when combined with Oxybutynin.
Orphenadrine Orphenadrine The metabolism of Nintedanib can be decreased when combined with Orphenadrine.
Phentermine Phentermine The metabolism of Nintedanib can be decreased when combined with Phentermine.
Hydrocortisone Hydrocortisone The metabolism of Nintedanib can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Nintedanib can be decreased when combined with Doxorubicin.
Dactinomycin Dactinomycin The serum concentration of Nintedanib can be increased when it is combined with Dactinomycin.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be increased when combined with Nintedanib.
Clonidine Clonidine The metabolism of Clonidine can be decreased when combined with Nintedanib.
Hydralazine Hydralazine The metabolism of Nintedanib can be decreased when combined with Hydralazine.
Cimetidine Cimetidine The metabolism of Nintedanib can be decreased when combined with Cimetidine.
Warfarin Warfarin The risk or severity of bleeding can be increased when Warfarin is combined with Nintedanib.
Loperamide Loperamide The metabolism of Nintedanib can be decreased when combined with Loperamide.
Daunorubicin Daunorubicin The metabolism of Nintedanib can be decreased when combined with Daunorubicin.
Griseofulvin Griseofulvin The metabolism of Nintedanib can be increased when combined with Griseofulvin.
Digoxin Digoxin The serum concentration of Digoxin can be increased when it is combined with Nintedanib.
Loxapine Loxapine The serum concentration of Nintedanib can be increased when it is combined with Loxapine.
Quinine Quinine The serum concentration of Nintedanib can be increased when it is combined with Quinine.
Calcitriol Calcitriol The metabolism of Nintedanib can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Nintedanib can be increased when combined with Sulfinpyrazone.
Secobarbital Secobarbital The metabolism of Nintedanib can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Nintedanib can be decreased when combined with Desipramine.
Amitriptyline Amitriptyline The metabolism of Nintedanib can be decreased when combined with Amitriptyline.
Imipramine Imipramine The serum concentration of Imipramine can be increased when it is combined with Nintedanib.
Probenecid Probenecid The metabolism of Nintedanib can be increased when combined with Probenecid.
Quinidine Quinidine The metabolism of Quinidine can be decreased when combined with Nintedanib.
Isoniazid Isoniazid The metabolism of Nintedanib can be decreased when combined with Isoniazid.
Rifampin Rifampin The serum concentration of Rifampicin can be decreased when it is combined with Nintedanib.
Valproic Acid Valproic Acid The metabolism of Nintedanib can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Nintedanib can be decreased when combined with Tamoxifen.
Levothyroxine Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Nintedanib.
Liothyronine Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Nintedanib.
Methimazole Methimazole The therapeutic efficacy of Methimazole can be decreased when used in combination with Nintedanib.
Propylthiouracil Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Nintedanib.
Niacin Niacin The metabolism of Nintedanib can be decreased when combined with Niacin.
Danazol Danazol The metabolism of Nintedanib can be decreased when combined with Danazol.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Nintedanib.
Amphotericin B Injection Amphotericin B Injection The metabolism of Nintedanib can be decreased when combined with Amphotericin B.
Clomiphene Clomiphene The serum concentration of Nintedanib can be increased when it is combined with Clomifene.
Colchicine Colchicine The metabolism of Nintedanib can be increased when combined with Colchicine.
Cephalexin Cephalexin The metabolism of Nintedanib can be decreased when combined with Cephalexin.
Acetazolamide Acetazolamide The metabolism of Nintedanib can be decreased when combined with Acetazolamide.
Calcitonin Salmon Injection Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Nintedanib.
Ketoconazole Ketoconazole The serum concentration of Nintedanib can be increased when it is combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Nintedanib.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be decreased when combined with Nintedanib.
Dipyridamole Dipyridamole The risk or severity of bleeding can be increased when Dipyridamole is combined with Nintedanib.
Vinblastine Vinblastine The metabolism of Nintedanib can be decreased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Nintedanib can be decreased when combined with Metoprolol.
Aspirin Aspirin The risk or severity of bleeding can be increased when Acetylsalicylic acid is combined with Nintedanib.
Diltiazem Diltiazem The metabolism of Nintedanib can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Nintedanib can be increased when combined with Nifedipine.
Verapamil Verapamil The serum concentration of Nintedanib can be increased when it is combined with Verapamil.
Etoposide Etoposide The metabolism of Nintedanib can be decreased when combined with Etoposide.
Glyburide Glyburide The metabolism of Nintedanib can be decreased when combined with Glyburide.
Dicloxacillin Dicloxacillin The metabolism of Nintedanib can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Nintedanib can be increased when combined with Nafcillin.
Gemfibrozil Gemfibrozil The metabolism of Nintedanib can be decreased when combined with Gemfibrozil.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Nintedanib.
Flurbiprofen Flurbiprofen The metabolism of Nintedanib can be decreased when combined with Flurbiprofen.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Nintedanib.
Lovastatin Lovastatin The metabolism of Nintedanib can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Nintedanib can be decreased when combined with Ciprofloxacin.
Clozapine Clozapine The metabolism of Nintedanib can be decreased when combined with Clozapine.
Clarithromycin Clarithromycin The metabolism of Nintedanib can be decreased when combined with Clarithromycin.
Felodipine Felodipine The metabolism of Nintedanib can be decreased when combined with Felodipine.
Pravastatin Pravastatin The serum concentration of Nintedanib can be increased when it is combined with Pravastatin.
Simvastatin Simvastatin The serum concentration of Nintedanib can be increased when it is combined with Simvastatin.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Nintedanib.
Teniposide Injection Teniposide Injection The metabolism of Nintedanib can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Nintedanib can be decreased when combined with Itraconazole.
Rifabutin Rifabutin The metabolism of Nintedanib can be increased when combined with Rifabutin.
Bisoprolol Bisoprolol The serum concentration of Nintedanib can be increased when it is combined with Bisoprolol.
Doxazosin Doxazosin The metabolism of Nintedanib can be decreased when combined with Doxazosin.
Isradipine Isradipine The metabolism of Nintedanib can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Nintedanib can be increased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Nintedanib can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Nintedanib can be decreased when combined with Fluvastatin.
Famciclovir Famciclovir The metabolism of Nintedanib can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine The metabolism of Nintedanib can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Nintedanib can be decreased when combined with Nefazodone.
Lamotrigine Lamotrigine The metabolism of Nintedanib can be increased when combined with Lamotrigine.
Losartan Losartan The metabolism of Nintedanib can be decreased when combined with Losartan.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Nintedanib.
Lansoprazole Lansoprazole The metabolism of Nintedanib can be increased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Nintedanib can be decreased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Nintedanib can be decreased when combined with Nicardipine.
Ticlopidine Ticlopidine The metabolism of Nintedanib can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Saquinavir can be decreased when combined with Nintedanib.
Dalteparin Injection Dalteparin Injection The risk or severity of bleeding can be increased when Dalteparin is combined with Nintedanib.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Nintedanib.
Indinavir Indinavir The metabolism of Nintedanib can be decreased when combined with Indinavir.
Ritonavir Ritonavir The serum concentration of Nintedanib can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Nintedanib can be decreased when combined with Docetaxel.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Nintedanib.
Zafirlukast Zafirlukast The metabolism of Nintedanib can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The metabolism of Nintedanib can be decreased when combined with Mirtazapine.
Topiramate Topiramate The metabolism of Nintedanib can be increased when combined with Topiramate.
Nelfinavir Nelfinavir The metabolism of Nintedanib can be increased when combined with Nelfinavir.
Fexofenadine Fexofenadine The serum concentration of Nintedanib can be increased when it is combined with Fexofenadine.
Azithromycin Azithromycin The metabolism of Nintedanib can be decreased when combined with Azithromycin.
Carvedilol Carvedilol The serum concentration of Nintedanib can be increased when it is combined with Carvedilol.
Bicalutamide Bicalutamide The metabolism of Nintedanib can be decreased when combined with Bicalutamide.
Propafenone Propafenone The serum concentration of Nintedanib can be increased when it is combined with Propafenone.
Raloxifene Raloxifene The metabolism of Nintedanib can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Nintedanib can be decreased when combined with Irbesartan.
Paroxetine Paroxetine The metabolism of Nintedanib can be decreased when combined with Paroxetine.
Citalopram Citalopram The metabolism of Nintedanib can be decreased when combined with Citalopram.
Efavirenz Efavirenz The metabolism of Nintedanib can be decreased when combined with Efavirenz.
Sildenafil Sildenafil The serum concentration of Nintedanib can be increased when it is combined with Sildenafil.
Rabeprazole Rabeprazole The metabolism of Nintedanib can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Nintedanib can be increased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists