Captopril
Captopril is an ACE inhibitor used to treat high blood pressure, heart failure, left ventricular dysfunction after a heart attack, and kidney disease caused by diabetes.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 16 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
Captopril, the first ACE inhibitor (on the market since about 1981, available as a generic), treats high blood pressure, heart failure, weak heart pumping after a heart attack and diabetes-related kidney disease by blocking the enzyme that makes angiotensin II, which tightens blood vessels and makes the body hold salt and water; it is an older standby, largely replaced by longer-acting relatives. It is usually well tolerated, though a dry cough, an itchy rash or dulled taste can appear. Its boxed warning, the strongest kind, is about pregnancy because it can injure or kill a developing baby, and swelling of the face, lips, tongue or throat needs emergency care.
Clinical pearls
- Take it one hour before meals, because food cuts how much captopril your body absorbs.
- Expect blood tests for potassium and kidney function, especially early on or if you already have kidney disease.
- Never take it with sacubitril/valsartan, and allow a 36-hour gap when switching to or from that heart failure drug.
- Report fever, sore throat or other signs of infection promptly, since captopril can lower white blood cell counts.
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾
Captopril can seriously harm or kill a developing baby if taken during pregnancy. If you become pregnant, contact your doctor right away so the medicine can be stopped as soon as possible. Do not stop on your own without talking to your prescriber if you are unsure.
Patient information guide A plain-language walkthrough of Captopril, written from its FDA label.
What Captopril is used for
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Captopril tablets are approved for several conditions:
- High blood pressure, alone or with other medicines, especially thiazide-type diuretics
- Heart failure, usually with a diuretic and digitalis
- Left ventricular dysfunction after a heart attack, to improve survival and reduce heart failure and related hospital stays
- Diabetic nephropathy in people with type 1 diabetes and retinopathy, to slow kidney disease progression
How Captopril works
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Captopril blocks ACE, the enzyme that turns angiotensin I into angiotensin II. Angiotensin II narrows blood vessels and prompts the body to hold salt and water. Blocking it relaxes blood vessels and lowers blood pressure.
Captopril may also affect bradykinin, another substance involved in blood vessel relaxation. The label says its exact mechanism is not fully understood.
Captopril dosage
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Captopril tablets are taken by mouth, usually two or three times a day, one hour before meals. Your dose is individualized and often raised gradually. People with kidney problems may need smaller or less frequent doses. Follow your prescriber and the label for what to do about missed doses.
Dosing details from the FDA-approved label
From the Captopril prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.
- Hypertension
- Initial dose 25 mg b.i.d. or t.i.d
- If blood pressure is not satisfactorily reduced after one or two weeks, may be increased to 50 mg b.i.d. or t.i.d
- If further reduction is required, may be increased to 100 mg b.i.d. or t.i.d. and then, if necessary, to 150 mg b.i.d. or t.i.d. while continuing the diuretic
- Usual dose range is 25 to 150 mg b.i.d. or t.i
- Maximum: 450 mg daily
- Take one hour before meals; if blood pressure is not controlled at 50 mg t.i.d. and the patient is not on a diuretic, add a modest dose of a thiazide-type diuretic (e.g., hydrochlorothiazide, 25 mg daily)
- Severe hypertension (e.g., accelerated or malignant hypertension)
- Continue diuretic, stop other antihypertensive medication, and promptly start captopril at 25 mg b.i.d. or t.i.d. under close medical supervision
- Daily dose may be increased every 24 hours or less under continuous medical supervision until a satisfactory blood pressure response is obtained or the maximum dose is reached
- Maximum: 450 mg daily
- A more potent diuretic, e.g., furosemide, may also be indicated
- Heart failure
- Usual initial daily dosage is 25 mg t.i.d
- After 50 mg t.i.d. is reached, delay further increases for at least two weeks where possible
- Most patients improve at 50 or 100 mg t.i.d
- Maximum: 450 mg daily
- For patients with normal or low blood pressure vigorously treated with diuretics (possibly hyponatremic and/or hypovolemic), start at 6.25 or 12.5 mg t.i.d., with titration to the usual daily dosage within the next several days; use with a diuretic and digitalis under very close medical supervision
- Left ventricular dysfunction after myocardial infarction
- May start as early as three days after MI
- After a single dose of 6.25 mg, initiate at 12.5 mg t.i.d
- Increase to 25 mg t.i.d. during the next several days and to a target dose of 50 mg t.i.d. over the next several weeks as tolerated
- Diabetic nephropathy
- 25 mg t.i.d. for long-term use
- Renal impairment
- Reduce initial daily dosage and use smaller increments for titration at one- to two-week intervals
- After the desired effect is achieved, slowly back-titrate to the minimal effective dose
- Patients may respond to smaller or less frequent doses; a loop diuretic (e.g., furosemide) rather than a thiazide is preferred if a diuretic is needed in severe renal impairment
Read the label’s full dosing text
DOSAGE AND ADMINISTRATION Captopril should be taken one hour before meals. Dosage must be individualized. Hypertension: Initiation of therapy requires consideration of recent antihypertensive drug treatment, the extent of blood pressure elevation, salt restriction, and other clinical circumstances. If possible, discontinue the patient’s previous antihypertensive drug regimen for one week before starting captopril. The initial dose of captopril tablets, USP is 25 mg b.i.d. or t.i.d. If satisfactory reduction of blood pressure has not been achieved after one or two weeks, the dose may be increased to 50 mg b.i.d. or t.i.d. Concomitant sodium restriction may be beneficial when captopril is used alone. The dose of captopril in hypertension usually does not exceed 50 mg t.i.d. Therefore, if the blood pressure has not been satisfactorily controlled after one to two weeks at this dose, (and the patient is not already receiving a diuretic), a modest dose of a thiazide-type diuretic (e.g., hydrochlorothiazide, 25 mg daily), should be added. The diuretic dose may be increased at one-to two-week intervals until its highest usual antihypertensive dose is reached. If captopril is being started in a patient already receiving a diuretic, captopril therapy should be initiated under close medical supervision (see WARNINGS and PRECAUTIONS: Drug Interactions regarding hypotension ), with dosage and titration of captopril as noted above. If further blood pressure reduction is required, the dose of captopril may be increased to 100 mg b.i.d. or t.i.d. and then, if necessary, to 150 mg b.i.d. or t.i.d. (while continuing the diuretic). The usual dose range is 25 to 150 mg b.i.d. or t.i.d. A maximum daily dose of 450 mg captopril should not be exceeded. For patients with severe hypertension (e.g., accelerated or malignant hypertension), when temporary discontinuation of current antihypertensive therapy is not practical or desirable, or when prompt titration to more normotensive blood pressure levels is indicated, diuretic should be continued but other current antihypertensive medication stopped and captopril dosage promptly initiated at 25 mg b.i.d. or t.i.d., under close medical supervision.
Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →
Captopril side effects
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Most side effects are mild. Common ones include:
Common side effects
- Skin rash, sometimes with itching, often in the first four weeks
- Itching without a rash
- Loss or reduced sense of taste (usually reversible)
- Cough
- Dizziness
- Headache
- Fatigue
- Nausea or stomach upset
- Nausea, stomach upset or diarrhea
When to get medical help
- Get emergency help right away for swelling of the face, lips, tongue, throat or limbs, or trouble breathing. This is angioedema and can block your airway.
- Call your doctor about belly pain with or without nausea or vomiting. Intestinal angioedema has been reported with ACE inhibitors.
- Call your doctor for signs of low white blood cell counts (neutropenia/agranulocytosis), since this is a known risk.
- Call your doctor for yellowing of the skin or eyes (jaundice), which can signal liver problems.
- Call your doctor for severe skin reactions, such as blistering or peeling.
- Report fainting or very low blood pressure symptoms.
- Tell your doctor if you become pregnant while taking it.
Seek urgent help for swelling of the face, lips, tongue or throat, or trouble breathing. Call your doctor for infection signs, jaundice or severe skin reactions.
Captopril warnings and precautions
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- Pregnancy: can cause injury and death to the developing baby.
- Angioedema: swelling that can block the airway. Higher rate in Black patients.
- Neutropenia/agranulocytosis: low white blood cell counts, especially in kidney disease or collagen vascular disease.
- Low blood pressure: more likely with diuretics, low salt or dehydration.
- Kidneys and potassium: potassium and kidney tests can rise.
- Allergic-type reactions: reported during venom desensitization, certain dialysis membranes and LDL apheresis.
Captopril interactions
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Several medicines can clash with captopril:
- ARBs, other ACE inhibitors and aliskiren: raise the risk of low blood pressure, high potassium and kidney injury
- Aliskiren in people with diabetes: do not combine
- Sacubitril/valsartan: must not be combined; wait 36 hours when switching
- mTOR inhibitors such as sirolimus: may increase angioedema risk
- Diuretics: add to blood pressure lowering, so start under supervision
Interactions listed in the FDA-approved label
From the Captopril prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.
- Dual blockade of the renin-angiotensin system (angiotensin receptor blockers, ACE inhibitors, aliskiren): Dual blockade is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy, with no additional benefit for most patients. In general, avoid combined use of RAS inhibitors; closely monitor blood pressure, renal function and electrolytes; do not coadminister aliskiren with captopril in patients with diabetes; avoid aliskiren with captopril in patients with renal impairment.
Read the label’s full interactions text
Drug Interactions Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Most patients receiving the combination of two RAS inhibitors do not obtain any additional benefit compared to monotherapy. In general, avoid combined use of RAS inhibitors. Closely monitor blood pressure, renal function and electrolytes in patients on captopril and other agents that block the RAS. Do not coadminister aliskiren with captopril in patients with diabetes. Avoid use of aliskiren with captopril in patients with renal impairment (GFR <60 ml/min). Non-Steroidal Anti-Inflammatory Agents including Selective Cyclooxygenase – 2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including captopril, may result in deterioration of renal function, including possible acute renal failure. These effects are usually reversible. Monitor renal function periodically in patients receiving captopril and NSAID therapy. The antihypertensive effect of ACE inhibitors, including captopril, may be attenuated by NSAIDs. Hypotension - Patients on Diuretic Therapy: Patients on diuretics and especially those in whom diuretic therapy was recently instituted, as well as those on severe dietary salt restriction or dialysis, may occasionally experience a precipitous reduction of blood pressure usually within the first hour after receiving the initial dose of captopril.
Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →
Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.
Before taking Captopril
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- Do not use if allergic to captopril or any ACE inhibitor, including past angioedema
- Do not use during pregnancy; tell your doctor right away if you become pregnant
- Tell your doctor about kidney disease or collagen vascular disease
- Mention diuretic use, low-salt diets or dehydration
- Tell your doctor if you have diabetes and take aliskiren
Captopril overdose
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The main concern with too much captopril is very low blood pressure. The label says treatment is usually an intravenous saline infusion to restore blood pressure. Hemodialysis can remove captopril in adults, but peritoneal dialysis does not. Seek emergency care or call poison control.
What Captopril does in the body
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Captopril relaxes the arteries, which lowers blood pressure. Blood pressure is usually lowest 60 to 90 minutes after a dose, and full effect may take several weeks. In heart failure it lowers the workload on the heart and improves exercise tolerance. Stopping it suddenly has not been linked to a rapid blood pressure rise.
How your body processes Captopril
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Captopril is absorbed quickly, with peak blood levels at about one hour. Food lowers absorption by about 30 to 40 percent, so it is taken before meals. Most of it leaves in the urine within 24 hours. Its half-life is probably under 2 hours, and it builds up in people with kidney problems.
How to store Captopril
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Store at 20° to 25°C (68° to 77°F) . Protect from moisture. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.
Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
Supplements & herbs that interact with Captopril
166 supplements and herbal products have documented interactions with Captopril in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.
- Major · 6
- Moderate · 136
- Minor · 24
Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.
Nutrient depletion considerations
Captopril has been associated with lower levels of 2 nutrients in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.
- Higher significance · 1
- Unrated · 1
Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.
Captopril: pharmacist answers to common questions
Quick, plain-English answers to the questions patients ask most about Captopril — the kind of thing our pharmacy team would talk through with you at the counter.
What is captopril for?
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How should I take it?
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What side effects should I expect?
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When should I get urgent help?
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Can I take it if I’m pregnant?
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Are there medicines I should avoid with it?
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Is Captopril available over the counter?
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When was Captopril first available?
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Who makes Captopril?
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Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
More about Captopril on HelloPharmacist
Captopril forms and strengths (how it comes)
Captopril is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Tablet
How this form is used
- Captopril tablets treat high blood pressure.
- Captopril tablets treat heart failure, usually with a diuretic and digitalis.
- Captopril tablets are used after a heart attack for left ventricular dysfunction.
- Captopril tablets treat diabetic nephropathy in type 1 diabetes with retinopathy.
- Captopril tablets should be taken by mouth one hour before meals.
- Captopril tablets are dosed individually, so follow your prescriber’s directions.
- Captopril tablets may need lower doses and slower increases if you have kidney problems.
Captopril on the U.S. market: products, makers and brands
How Captopril appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
13 companies list 47 Captopril product records with the FDA, mostly as tablet; the earliest marketing or approval year on record is 1981. Brand names on the directory include Capoten; the rest are generics.
Also listed with the FDA, not a patient dose form: Powder (4) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
How widely Captopril is used (Medicaid data)
A general measure of how commonly Captopril is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Captopril is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Captopril prescribed? Of the 1,601 medications we measure, Captopril ranks #979 by Medicaid prescriptions — more than 39% of them.
Utilization by Captopril product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
captopril 25 MG Oral Tablet Most dispensed
Summed across the 6 of 57 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 317173
captopril 50 MG Oral Tablet
Summed across the 5 of 37 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 308964
captopril 12.5 MG Oral Tablet
Summed across the 4 of 34 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 308963
captopril 100 MG Oral Tablet
Summed across the 2 of 21 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 308962
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Captopril, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 17 of 149 listed Captopril NDCs with Medicaid activity.
Compare Captopril products
A representative set of FDA-listed product records for Captopril — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Tablet | ||||
| 12.5 mg | Oral | AiPing Pharmaceutical, Inc. | ANDA | View NDC → |
| 25 mg | Oral | AiPing Pharmaceutical, Inc. | ANDA | View NDC → |
| 50 mg | Oral | AiPing Pharmaceutical, Inc. | ANDA | View NDC → |
| 100 mg | Oral | AiPing Pharmaceutical, Inc. | ANDA | View NDC → |
| 12.5 mg | Oral | Ajanta Pharma USA Inc. | ANDA | View NDC → |
| 25 mg | Oral | Ajanta Pharma USA Inc. | ANDA | View NDC → |
| 50 mg | Oral | Ajanta Pharma USA Inc. | ANDA | View NDC → |
| 100 mg | Oral | Ajanta Pharma USA Inc. | ANDA | View NDC → |
| 12.5 mg | Oral | American Health Packaging | ANDA | View NDC → |
| 25 mg | Oral | American Health Packaging | ANDA | View NDC → |
| 12.5 mg | Oral | Amici Pharma, Inc. | ANDA | View NDC → |
| 25 mg | Oral | Amici Pharma, Inc. | ANDA | View NDC → |
| 50 mg | Oral | Amici Pharma, Inc. | ANDA | View NDC → |
| 100 mg | Oral | Amici Pharma, Inc. | ANDA | View NDC → |
| 12.5 mg | Oral | AvKARE | ANDA | View NDC → |
| 25 mg | Oral | AvKARE | ANDA | View NDC → |
| 50 mg | Oral | AvKARE | ANDA | View NDC → |
| 25 mg | Oral | Bryant Ranch Prepack | ANDA | View NDC → |
| 50 mg | Oral | Bryant Ranch Prepack × 2 listings | ANDA | View NDC → |
| 12.5 mg | Oral | Camber Pharmaceuticals, Inc. | ANDA | View NDC → |
| 25 mg | Oral | Camber Pharmaceuticals, Inc. | ANDA | View NDC → |
| 50 mg | Oral | Camber Pharmaceuticals, Inc. | ANDA | View NDC → |
| 100 mg | Oral | Camber Pharmaceuticals, Inc. | ANDA | View NDC → |
| 12.5 mg | Oral | Golden State Medical Supply, Inc. | ANDA | View NDC → |
| 25 mg | Oral | Golden State Medical Supply, Inc. | ANDA | View NDC → |
| 50 mg | Oral | Golden State Medical Supply, Inc. | ANDA | View NDC → |
| 100 mg | Oral | Golden State Medical Supply, Inc. | ANDA | View NDC → |
| 12.5 mg | Oral | Hikma Pharmaceuticals USA Inc. | ANDA | View NDC → |
| 25 mg | Oral | Hikma Pharmaceuticals USA Inc. | ANDA | View NDC → |
| 50 mg | Oral | Hikma Pharmaceuticals USA Inc. | ANDA | View NDC → |
| 100 mg | Oral | Hikma Pharmaceuticals USA Inc. | ANDA | View NDC → |
| 12.5 mg | Oral | Major Pharmaceuticals | ANDA | View NDC → |
| 25 mg | Oral | Major Pharmaceuticals | ANDA | View NDC → |
| 12.5 mg | Oral | Method Pharmaceuticals LLC × 2 listings | ANDA | View NDC → |
| 25 mg | Oral | Method Pharmaceuticals LLC × 2 listings | ANDA | View NDC → |
| 50 mg | Oral | Method Pharmaceuticals LLC × 2 listings | ANDA | View NDC → |
| 100 mg | Oral | Method Pharmaceuticals LLC × 2 listings | ANDA | View NDC → |
| 25 mg | Oral | PD-Rx Pharmaceuticals, Inc. | ANDA | View NDC → |
| 12.5 mg | Oral | Solco Healthcare US, LLC | ANDA | View NDC → |
| 25 mg | Oral | Solco Healthcare US, LLC | ANDA | View NDC → |
| 50 mg | Oral | Solco Healthcare US, LLC | ANDA | View NDC → |
| 100 mg | Oral | Solco Healthcare US, LLC | ANDA | View NDC → |
Showing 47 of 47 products — FDA National Drug Code Directory. See every product, package size and price: browse all 47 Captopril NDCs →
Captopril side effects reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Captopril — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Captopril in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
Captopril FDA approval history
How Captopril went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
Captopril recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
The FDA’s enforcement reports list no Captopril recalls since July 2021.
✅No Captopril recalls on record since July 2021Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 1998 1 dose form · 4 strengths
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Dose form (SCDF) Oral Tablet RxCUI 371254In current FDA listings
Look up RxCUI 1998 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
Captopril supply and shortage status
Whether Captopril is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
💵 What Captopril costs pharmacies (NADAC benchmark)
The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.
| Form | Strength | Pharmacy acquisition benchmark | |
|---|---|---|---|
| Tablet · Oral | 25 mg | $0.173 per tablet | NDC details & price history |
| Tablet · Oral | 12.5 mg | $0.228 per tablet | NDC details & price history |
| Tablet · Oral | 50 mg | $0.369 per tablet | NDC details & price history |
| Tablet · Oral | 100 mg | $0.323 per tablet | NDC details & price history |
Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.
Captopril brand names
Captopril is sold under one brand name in the FDA directory — Capoten. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.
Who makes Captopril: manufacturers and labelers
13 companies list Captopril products with the FDA. By number of product records, the largest are Method Pharmaceuticals LLC, Amici Pharmaceuticals Llc, AiPing Pharmaceutical, Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.
Captopril drug class (RxNorm)
Captopril belongs to the Angiotensin Converting Enzyme Inhibitor class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
Sources for this Captopril page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How this page is built
HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Camber Pharmaceuticals, Inc. is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →