Can You Take Collagen With Blood Pressure Medications?

In our latest question and answer, the pharmacist discusses whether or not collagen supplements are safe to take with blood pressure medication.

2 min read Updated Jun 2026 Read by 18,124 people
Can You Take Collagen With Blood Pressure Medications?
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Shana asked

Can I take Vital Proteins collagen with my blood pressure med (Bystolic)?

Jul 13, 2022
The quick answer
  • Collagen peptides are safe to take with blood pressure medications including Bystolic and other common blood pressure drugs, with no known interactions.
  • Collagen is simply a type of protein that is common in the diet and does not affect blood pressure.
  • The main side effects from collagen supplements are generally mild and limited to nausea and gas if they occur at all.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.

Answer

Hello and thanks for reaching out to us! We've received a few questions recently regarding collagen peptides and are more than happy to provide some guidance here.

Collagen peptides (including collagen manufactured by Vital Proteins) are safe to take with blood pressure medications. Collagen peptides are not known to affect blood pressure, and there is especially no evidence that it raises blood pressure. You can feel safe taking collagen with Bystolic.

Not only is collagen safe with Bystolic, as mentioned, it doesn't affect blood pressure, and there are no known interactions with any blood pressure medication. This would include:

  • Lisinopril
  • Ramipril
  • Amlodipine
  • Enalapril
  • Captopril
  • Benazepril
  • Quinapril
  • Losartan
  • Valsartan
  • Irbesartan
  • Doxazosin
  • Bisoprolol
  • Telmisartan
  • Metoprolol
  • Propranolol

Remember that collagen is simply a type of protein (which I discuss further in the next section), and is very common in the human diet. Unless protein specifically interacts with your drug (which is uncommon), there is no interaction to be worried about. Be sure to still follow the directions for your specific medication however regarding whether or not it should be taken with food.

What Are Collagen Peptides?

Collagen peptides, also known as hydrolyzed collagen and collagen hydrolysate, are small protein molecules and the primary protein constituent in ligaments, tendons, and skin.

Collagen peptides are generally more absorbable than larger protein molecules (studies suggest collagen peptides are more than 90% absorbable).

A very popular dietary supplement, studies suggest that supplementing with collagen peptides can improve skin hydration and elasticity. They are also used to support wound healing and bone health. It is very well tolerated, and reported side effects from supplementation are generally limited to mild nausea and gas (if they occur at all).

Collagen peptides are soluble in water, and tend to mix easily, unlike gelatin (which is also derived from collagen).

What Is Bystolic?

Bystolic (nebivolol) is used alone or in combination with other medications to treat high blood pressure. Nebivolol is in a class of medications called beta-blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure.

Final Words

Thanks again for your question! You can feel safe combining collagen peptides and Effexor as they are safe together.

References & sources
  1. Oral Collagen Supplementation: A Systematic Review of Dermatological Applications — PubMed
  2. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis — PubMed
  3. A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study — PubMed
  4. Bystolic Prescribing Information — AccessFDA
Glossary — Terms in This Answer
Collagen peptides
Small protein molecules that are the primary protein found in ligaments, tendons, and skin, also known as hydrolyzed collagen.
Hydrolyzed collagen
Collagen that has been broken down into smaller, more easily absorbed protein molecules.
Beta-blockers
A class of medications that work by slowing heart rate and relaxing blood vessels to lower blood pressure.
Nebivolol
The active ingredient in the medication Bystolic, used to treat high blood pressure.
Blood vessels
Tubes in the body that carry blood throughout the system.
Absorbable
Able to be taken up and used by the body.
Ligaments
Tough connective tissues that connect bones to other bones.
Tendons
Connective tissues that attach muscles to bones.
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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