Skip to the answer

Cyanocobalamin

Cyanocobalamin is a form of vitamin B12 used to treat and prevent vitamin B12 deficiency, including deficiency from pernicious anemia and poor absorption, as an injection or a nasal spray.

Brand names DodexNascobalDodex InjectableCoco12Non-proprietary name +2 more
Drug class Vitamin B12
Rx/OTC Forms 3
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 33 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

How we combine label and product data →
✓No current FDA shortage listed · checked Oct 3, 2026 🚨Recall on record
Other forms & routes:
Injection Nasal
Cyanocobalamin at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written
Cyanocobalamin replaces vitamin B12 when your body is not getting or absorbing enough, including in pernicious anemia. It comes as an injection or a nasal spray, each with its own uses. Follow your prescriber’s plan and keep up with blood tests.
How we write & review this content — our editorial policy →
How you get itPrescription and over the counter
Comes asInjection, Nasal spray, Topical cream, ointment or gel
Earliest FDA record1971
Companies listing it with the FDA45
FDA label last updatedDec 20, 2024
FDA’s strongest warning (boxed)None on the label

Patient information guide — a plain-language walkthrough of Cyanocobalamin, written from its FDA label.

What Cyanocobalamin is used for

▾

Cyanocobalamin treats and prevents vitamin B12 deficiency. Uses differ by product.

  • Injection (including Vitamin Deficiency System and other cyanocobalamin injections): B12 deficiency from malabsorption, linked to pernicious anemia, stomach or bowel disease or surgery, fish tapeworm, cancer of the pancreas or bowel, or folic acid deficiency.
  • Injection: also suitable for the B12 absorption (Schilling) test.
  • Nascobal and cyanocobalamin nasal spray: maintenance in adults with pernicious anemia in remission after B12 injections and with no nervous system involvement.
  • Nasal spray: adult B12 deficiency from diet, drugs or malabsorption that is not due to pernicious anemia.
  • Nasal spray: prevention of deficiency in adults with higher-than-normal B12 needs.

How Cyanocobalamin works

▾

Your body turns vitamin B12 into coenzyme B12. This helps convert methylmalonate to succinate and helps make methionine from homocysteine, a step that also needs folate. Without it, a functional folate deficiency can occur. B12 is tied to fat and carbohydrate metabolism and protein synthesis.

Cyanocobalamin dosage

▾

Cyanocobalamin comes as an injection and a nasal spray.

  • Injection: given into a muscle or deep under the skin, never into a vein. Pernicious anemia generally needs lifelong B12 by injection.
  • Nasal spray (Nascobal and others): generally one spray in one nostril once weekly, at least an hour before or after hot foods or drinks.

Follow your prescriber and product label. Blood levels are checked periodically.

Dosing details from the FDA-approved label

From the Cyanocobalamin prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Nasal spray (Nascobal / Cyanocobalamin Nasal Spray): initial dose
    • One spray (500 mcg) in ONE nostril once weekly
    • Administer at least one hour before or one hour after ingestion of hot foods or liquids; defer use in patients with nasal congestion, allergic rhinitis, or upper respiratory infections until symptoms have subsided
  • Nasal spray: dosage modification if serum B12 declines after one month
    • Consider increasing the dose
    • Assess serum B12 level one month after each dose adjustment
    • If serum B12 levels are persistently low, consider alternative therapy (e.g., intramuscular or subcutaneous vitamin B12 therapy)
  • Pernicious anemia (injection)
    • 100 mcg daily for 6 or 7 days by intramuscular or deep subcutaneous injection
    • If clinical improvement and reticulocyte response, same amount on alternate days for seven doses, then every 3 to 4 days for another 2 to 3 weeks, followed by 100 mcg monthly for life
    • Avoid the intravenous route; folic acid should be administered concomitantly if needed
  • Patients with normal intestinal absorption (injection)
    • Where the oral route is not deemed adequate, initial treatment similar to that for pernicious anemia may be indicated depending on severity of deficiency
    • Chronic treatment should be with an oral B12 preparation
    • If other vitamin deficiencies are present, they should be treated
  • Schilling test
    • Flushing dose is 1000 mcg
  • Cyanocobalamin Injection 2 mg/mL multi-dose vial
    • Dosage and frequency individualized by the prescribing healthcare provider based on severity of deficiency, patient condition, laboratory monitoring, and therapeutic response
    • Intramuscular or subcutaneous injection only
    • Administered by a licensed healthcare professional; not for self-administration
Read the label’s full dosing text

DOSAGE AND ADMINISTRATION Avoid using the intravenous route. Use of this product intravenously will result in almost all of the vitamin being lost in the urine. Pernicious Anemia Parenteral Vitamin B 12 is the recommended treatment and will be required for the remainder of the patient’s life. The oral form is not dependable. A dose of 100 mcg daily for six or seven days should be administered by intramuscular or deep subcutaneous injection. If there is clinical improvement and if a reticulocyte response is observed, the same amount may be given on alternate days for seven doses, then every three to four days for another two to three weeks. By this time hematologic values should have become normal. This regimen should be followed by 100 mcg monthly for life. Folic acid should be administered concomitantly if needed. Patients With Normal Intestinal Absorption Where the oral route is not deemed adequate, initial treatment similar to that for patients with pernicious anemia may be indicated depending on the severity of the deficiency. Chronic treatment should be with an oral B 12 preparation. If other vitamin deficiencies are present, they should be treated. Schilling test The flushing dose is 1000 mcg. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

Pernicious Anemia Parenteral Vitamin B 12 is the recommended treatment and will be required for the remainder of the patient’s life. The oral form is not dependable. A dose of 100 mcg daily for six or seven days should be administered by intramuscular or deep subcutaneous injection. If there is clinical improvement and if a reticulocyte response is observed, the same amount may be given on alternate days for seven doses, then every three to four days for another two to three weeks. By this time hematologic values should have become normal. This regimen should be followed by 100 mcg monthly for life. Folic acid should be administered concomitantly if needed.

Patients With Normal Intestinal Absorption Where the oral route is not deemed adequate, initial treatment similar to that for patients with pernicious anemia may be indicated depending on the severity of the deficiency. Chronic treatment should be with an oral B 12 preparation. If other vitamin deficiencies are present, they should be treated.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Cyanocobalamin side effects

▾

Common side effects

  • Infection (such as sore throat or common cold)
  • Headache
  • Weakness or tiredness (asthenia)
  • Nausea
  • Sore, inflamed tongue (glossitis)
  • Tingling or pins and needles (paresthesia)
  • Runny or stuffy nose (rhinitis)

When to get medical help

  • Get emergency help for signs of a severe allergic reaction. Anaphylactic shock and death have been reported after B12 injections.
  • Tell your doctor right away if you notice vision changes, especially if you have Leber’s disease.
  • Report any unusual symptoms during treatment of severe anemia. Low potassium and sudden death can occur with intense treatment.
  • Tell your doctor if you have a response suggesting polycythemia vera (a blood disorder with too many red blood cells). B12 treatment can reveal it.

Side effects named for the nasal spray include:

  • Infection (sore throat, cold)
  • Headache
  • Weakness
  • Nausea
  • Sore tongue
  • Tingling
  • Runny nose

Seek urgent help for allergic reaction signs or vision changes.

Cyanocobalamin warnings and precautions

▾
  • Severe allergic reaction, including anaphylaxis, has been reported after B12 injections.
  • Leber’s disease: severe, rapid optic nerve damage.
  • B12 can mask folate deficiency and unmask polycythemia vera.
  • Intense treatment of severe anemia can cause low potassium and high platelets.
  • Some injectables contain benzyl alcohol and aluminum, which matter for premature infants and people with kidney problems.

Cyanocobalamin interactions

▾

Few interactions are named on the label.

  • Chloramphenicol: may reduce how well the nasal spray treats anemia.
  • Drugs that cause vitamin malabsorption: can contribute to B12 deficiency.

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

Check Cyanocobalamin against a supplement or herb →

Before taking Cyanocobalamin

▾
  • Allergy to cobalt or B12: do not use.
  • Leber’s disease: not recommended.
  • Nasal spray with congestion, allergic rhinitis or a respiratory infection: wait until symptoms ease.
  • Pregnancy: B12 needs increase; nasal spray data are limited.
  • Breastfeeding: appears to pose no more than minimal risk.
  • Children: nasal spray safety and effectiveness not established.
  • Older adults: no differences identified.
  • Kidney problems: aluminum in some injectables can build up.

Cyanocobalamin overdose

▾

No overdose has been reported with this drug.

What Cyanocobalamin does in the body

▾

B12 given by injection fully reverses the megaloblastic anemia (large, immature red blood cells) and digestive symptoms of deficiency. Nerve symptoms improve depending on how long and severe they were, though progression stops right away. In pernicious anemia, weekly nasal gel raised B12 levels above those seen after a monthly injection.

How your body processes Cyanocobalamin

▾

B12 binds to intrinsic factor in the stomach and is absorbed in the lower small intestine. In the blood it travels on a carrier protein and is stored mainly in the liver and bone marrow. Nasal spray peaks in about 1 to 2 hours. Extra B12 beyond what the body can bind is quickly lost in urine, and less is retained at higher injected doses.

How to store Cyanocobalamin

▾

Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) . PROTECT FROM LIGHT.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

Cyanocobalamin: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Cyanocobalamin — the kind of thing our pharmacy team would talk through with you at the counter.

What is cyanocobalamin for?

▾
It replaces vitamin B12 when you are low. Doctors use it for deficiency from poor absorption, pernicious anemia, or a diet low in B12. The injection and the nasal spray are approved for somewhat different situations.

How do I use the nasal spray?

▾
The usual approach is one spray in one nostril once a week. Use it at least an hour before or after hot foods or drinks. Follow your prescriber and your product label.

Can I give myself the injection?

▾
Some injection products are labeled to be given by a healthcare professional and not for self-administration. Ask your prescriber how yours should be given. It should never go into a vein.

What side effects should I expect?

▾
With the nasal spray, people reported colds, headache, weakness, nausea, a sore tongue, tingling and a runny nose. Call your doctor about anything that bothers you. Get emergency help for signs of a severe allergic reaction.

Do I need blood tests?

▾
Yes. Your doctor checks B12 and other blood levels before and during treatment. Potassium and platelets may be checked too, especially with severe anemia.

Is it safe in pregnancy?

▾
B12 is an essential vitamin and needs go up in pregnancy. Data on the nasal spray in pregnancy are limited, so talk with your doctor. B12 passes into breast milk but does not appear to pose more than a minimal risk.

Is Cyanocobalamin available over the counter?

▾
Both — Cyanocobalamin is sold both over the counter and by prescription, according to its FDA labeling. Lower strengths or certain forms are often available without a prescription, while higher strengths or specialized forms still require one. Ask your pharmacist which version is right for you.

When was Cyanocobalamin first available?

▾
Cyanocobalamin has been available in the United States since at least 1971, based on FDA approval history (Drugs@FDA) and product marketing records.

Who makes Cyanocobalamin?

▾
Cyanocobalamin is supplied by 45 manufacturers listed in the FDA NDC Directory, including Somerset Therapeutics, LLC, Vitruvias Therapeutics, Hikma Pharmaceuticals USA Inc..

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Cyanocobalamin on HelloPharmacist

🌿Drug & Supplement CheckerCyanocobalamin vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Cyanocobalamin NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Cyanocobalamin Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Cyanocobalamin forms and strengths (how it comes)

Cyanocobalamin is available in 3 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Injection

Into a muscle · Under the skin
Brands Dodex Injectable Non-proprietary name Vitamin Deficiency System
How this form is used
What it may be used for
  • Cyanocobalamin injection treats vitamin B12 deficiency caused by malabsorption.
  • Cyanocobalamin injection is also suitable for the vitamin B12 absorption test (Schilling test).
Important instructions
  • Cyanocobalamin injection is given into a muscle or under the skin, and the intravenous route should be avoided.
  • The non-proprietary cyanocobalamin injection is given by a licensed healthcare professional and is not for self-administration.
  • For pernicious anemia, cyanocobalamin injection is typically needed for life.
Available strengths 2 strengths
1000 mcg/mL 2 mg/mL
103 FDA-listed product records ⓘ

Nasal spray

In the nose
Brands Nascobal
How this form is used
What it may be used for
  • Nascobal is for B12 maintenance in adults with pernicious anemia in remission and no nervous system involvement.
  • Nascobal treats adult B12 deficiency not due to pernicious anemia.
  • Nascobal prevents B12 deficiency in adults with higher-than-normal needs.
Important instructions
  • Nascobal is generally used as one spray in one nostril once weekly.
  • Use Nascobal at least one hour before or after hot foods or drinks.
  • Nascobal is not for the B12 absorption (Schilling) test.
Available strengths 1 strength
500 mcg
4 FDA-listed product records ⓘ

Topical cream, ointment or gel

On the skin
Brands Coco12
Available strengths 1 strength
0.05 g/0.05 g
1 FDA-listed product record ⓘ

Cyanocobalamin on the U.S. market: products, makers and brands

How Cyanocobalamin appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

45 companies list 127 Cyanocobalamin product records with the FDA, mostly as injection, nasal spray, topical cream, ointment or gel; the earliest marketing or approval year on record is 1971. Brand names on the directory include Dodex, Nascobal, Dodex Injectable and 4 more; the rest are generics.

3
Dose forms ⓘ
45
Labelers (makers, repackagers, distributors)
7
Brand names
127
FDA-listed product records ⓘ
1971
Earliest FDA record ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (18) · Kit (1) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Somerset Therapeutics, LLC7%
Vitruvias Therapeutics7%
Hikma Pharmaceuticals USA Inc.7%
HF Acquisition Co LLC, DBA HealthFirst6%
Meitheal Pharmaceuticals Inc.5%
American Regent, Inc.5%
Other makers62%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Cyanocobalamin is used (Medicaid data)

A general measure of how commonly Cyanocobalamin is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Cyanocobalamin is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

1,095,564
Medicaid prescriptions filled (Q1–Q4 2025)
$14.6M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Cyanocobalamin prescribed? Of the 1,599 medications we measure, Cyanocobalamin ranks #166 by Medicaid prescriptions — more than 90% of them.

Where Cyanocobalamin ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #166 of 1,599
#161 Epinephrine Injection 1,101,355 Rx #162 Clobetasol 1,099,263 Rx #163 Lithium 1,098,757 Rx #164 Lithium Carbonate 1,097,615 Rx #165 Fenofibrate 1,097,185 Rx #166 Cyanocobalamin 1,095,564 Rx #167 Clobetasol Topical 1,093,267 Rx #168 Cyanocobalamin Injecti... 1,087,734 Rx #169 Nifedipine 1,079,242 Rx #170 Cariprazine 1,076,596 Rx #171 Naltrexone 1,052,053 Rx

Utilization by Cyanocobalamin product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 1 mg/mL injectable solution is the most-dispensed Cyanocobalamin product — about 99% of these Medicaid prescriptions.

vitamin B12 1 MG/ML Injectable Solution Most dispensed

1,087,734 Medicaid prescriptions (Q1–Q4 2025) 99% of Cyanocobalamin prescriptions shown $10.9M gross reimbursement (before rebates) ≈ $10 per prescription (gross)

Summed across the 29 of 135 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 309594

vitamin B12 0.5 MG/ACTUAT Nasal Spray

7,830 Medicaid prescriptions (Q1–Q4 2025) <1% of Cyanocobalamin prescriptions shown $3.7M gross reimbursement (before rebates) ≈ $470 per prescription (gross)

Summed across the 2 of 6 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 861113

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Cyanocobalamin, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 31 of 141 listed Cyanocobalamin NDCs with Medicaid activity.

Compare Cyanocobalamin products

A representative set of FDA-listed product records for Cyanocobalamin — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 127 of 127 products — FDA National Drug Code Directory. See every product, package size and price: browse all 127 Cyanocobalamin NDCs →

Cyanocobalamin recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list 2 Cyanocobalamin recalls since July 2021, covering 3 product listings. One of them is still ongoing and is listed first. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.

Ongoing Class II Jul 24, 2026 · American Regent, Inc.
Presence of Particulate Matter: Product contaminated with particulate matter identified as hair, glass and/or paraformaldehyde
  • Cyanocobalamin injection USP, 10,000 mcg/10 mL (1,000 mcg/mL), For IM or SC Use Only, packaged in a) 10 mL Multi-Dose Vial (NDC 0517-0032-01) and b) 25x10 mL Multi-Dose Vials (NDC 0517-0032-25), Rx O… Lots: Lot #: 25082, Exp. Date: 3/31/2027. FDA record D-0793-2026 →
  • Cyanocobalamin injection USP, 1,000 mcg/mL, For IM or SC Use Only, packaged in a) 1 mL Multi-Dose Vial (NDC 0517-0031-01), and b) 25x1 mL Multi-Dose Vials (NDC 0517-0031-25) Rx only, AMERICAN REGENT,… Lots: Lot #: 24297, Exp. Date 8/31/2026; 24364, Exp. Date: 10/31/2026; FDA record D-0792-2026 →
Class III Apr 5, 2022 · Terminated · Aurobindo Pharma USA Inc.
Subpotent Drug: Out of Specification results for Assay
  • Cyanocobalamin Injection, USP, 1,000 mcg per mL, For IM or SC Use Only, 1 mL Vial, Rx Only, Manufactured in India, for Auromedics Pharma LLC, NDC 55150-364-01. Lots: Lots: CCC210004, Exp 09/2022; CCC210005, CCC210006, CCC210007, Exp 11/2022; CCC210010, CCC210011, Exp 04/2023. FDA record D-0766-2022 →

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Cyanocobalamin RxCUI 11248 12 dose forms · 49 strengths
  1. Dose form (SCDF) Chewable Tablet RxCUI 371648 No current FDA listing
    Clinical drug / strength (SCD) 0.5 MG RxCUI 2185309 1 MG RxCUI 198890 1.5 MG RxCUI 2682744 2.5 MG RxCUI 1486245 5 MG RxCUI 1804852
  2. Dose form (SCDF) Disintegrating Oral Tablet RxCUI 1291287 No current FDA listing
    Clinical drug / strength (SCD) 1 MG RxCUI 1374869 2 MG RxCUI 2714170 2.5 MG RxCUI 2735126 5 MG RxCUI 1291288
  3. Dose form (SCDF) Extended Release Oral Tablet RxCUI 371651 No current FDA listing
    Clinical drug / strength (SCD) 1 MG RxCUI 237776 1.5 MG RxCUI 240516 2 MG RxCUI 237777 5 MG RxCUI 1606305
  4. Dose form (SCDF) Injectable Solution RxCUI 371649 In current FDA listings
    Clinical drug / strength (SCD) 1 MG/ML RxCUI 309594 3 MG/ML RxCUI 1006047 5 MG/ML RxCUI 2001499
  5. Dose form (SCDF) Nasal Gel RxCUI 376662 No current FDA listing
    Clinical drug / strength (SCD) 0.005 MG/MG RxCUI 309611
  6. Dose form (SCDF) Nasal Spray RxCUI 378708 In current FDA listings
    Clinical drug / strength (SCD) 0.5 MG/ACTUAT RxCUI 861113
  7. Dose form (SCDF) Oral Capsule RxCUI 371646 No current FDA listing
    Clinical drug / strength (SCD) 1 MG RxCUI 245557 2 MG RxCUI 2171138 3 MG RxCUI 1245012 5 MG RxCUI 1653780
  8. Dose form (SCDF) Oral Film RxCUI 2745599 No current FDA listing
    Clinical drug / strength (SCD) 0.5 MG RxCUI 2745600
  9. Dose form (SCDF) Oral Lozenge RxCUI 375346 No current FDA listing
    Clinical drug / strength (SCD) 0.05 MG RxCUI 242347 0.1 MG RxCUI 199364 0.25 MG RxCUI 199374 0.5 MG RxCUI 199365 1 MG RxCUI 242698 2 MG RxCUI 200165 2.5 MG RxCUI 1437717 3 MG RxCUI 1246063
  10. Dose form (SCDF) Oral Solution RxCUI 348170 No current FDA listing
    Clinical drug / strength (SCD) 0.007 MG/ML RxCUI 105687 0.0667 MG/ML RxCUI 1112803 1 MG/ML RxCUI 1423423 3 MG/ML RxCUI 1488563 5 MG/ML RxCUI 1248737
  11. Dose form (SCDF) Oral Tablet RxCUI 371650 No current FDA listing
    Clinical drug / strength (SCD) 0.05 MG RxCUI 105686 0.1 MG RxCUI 309595 0.25 MG RxCUI 309604 0.5 MG RxCUI 313896 1 MG RxCUI 309593 2 MG RxCUI 244190 2.5 MG RxCUI 1245015
  12. Dose form (SCDF) Sublingual Tablet RxCUI 371652 No current FDA listing
    Clinical drug / strength (SCD) 0.5 MG RxCUI 636371 1 MG RxCUI 237779 2.5 MG RxCUI 198891 3 MG RxCUI 855213 5 MG RxCUI 199184 6 MG RxCUI 835519

Look up RxCUI 11248 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

Cyanocobalamin brand names

Cyanocobalamin is sold under 7 brand names in the FDA directory — Dodex, Nascobal, Dodex Injectable, Coco12 and others. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Dodex Nascobal Dodex Injectable Coco12 Non-proprietary name Vitamin Deficiency Injectable System - B12 Vitamin Deficiency System

Who makes Cyanocobalamin: manufacturers and labelers

40 companies list Cyanocobalamin products with the FDA. By number of product records, the largest are Somerset Therapeutics, LLC, Vitruvias Therapeutics, Hikma Pharmaceuticals USA Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Somerset Therapeutics, LLC 9 Vitruvias Therapeutics 9 Hikma Pharmaceuticals USA Inc. 9 HF Acquisition Co LLC, DBA HealthFirst 7 Meitheal Pharmaceuticals Inc. 6 American Regent, Inc. 6 Lifestar Pharma LLC 6 A-S Medication Solutions 4 Henry Schein, Inc. 4 Fresenius Kabi USA, LLC 4 BluePoint Laboratories 4 Gland Pharma Limited 3 Zydus Lifesciences Limited 3 Euroapi France 3 UBI Pharma Inc. 3 SOLA Pharmaceuticals 3 Zydus Pharmaceuticals USA Inc. 3 Asclemed USA, Inc. 3 Plano Pharmaceuticals Inc. 3 Northstar Rx LLC. 3 Willow Birch Pharma, LLC 2 Willow Birch Pharma, Inc. 2 NorthStar RxLLC 2 Accord Healthcare, Inc. 2

…and 16 more on the FDA NDC directory.

Cyanocobalamin drug class (RxNorm)

Cyanocobalamin belongs to the Vitamin B12 class.

Pharmacologic class Vitamin B12
Drug family (ATC) Vitamin B12 (cyanocobalamin and analogues)

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Cyanocobalamin page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Dec 20, 2024
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Cyanocobalamin.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Cyanocobalamin after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
33
NDC products indexed
127
Distinct labelers/manufacturers represented
45
Linked representative label ⓘ
Vitruvias Therapeutics
Linked label effective
Dec 20, 2024
Composite sections available
17
Linked SPL Set ID
2117af8a-723f-4e2f-98a6-83ad2c423751
Linked SPL Document ID
7c3b0e85-bd17-4998-aaf4-1a873a357ab4
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Vitruvias Therapeutics is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →