cyanocobalamin 1000 ug/mL Injection, 25 vials
Other active recalls for Cyanocobalamin (different manufacturers) — 2 · tap to view
🆔 Identity & classification
Where does this data come from?
🏷️ RxNorm drug class
This medicine belongs to the Vitamin B12 class.
Where does this data come from?
🏭 Manufacturer & labeler
Where does this data come from?
🩺 Clinical
Cyanocobalamin injection is used to treat and prevent a lack of vitamin B12 that may be caused by any of the following: pernicious anemia (lack of a natural substance needed to absorb vitamin B12 from the intestine); certain diseases, infections, or medications that decrease the amount of vitamin B12 absorbed from food; or a vegan diet (strict vegetarian diet that does not allow any animal products, including dairy products and eggs). Lack of vitamin B12 may cause anemia (condition in which the red blood cells do not bring enough oxygen to the organs) and permanent damage to the nerves. Cyanoc...
Read the full MedlinePlus article ↗- It's a prescription form of vitamin B12, used when your body can't get enough B12 on its own. That can happen because of a condition called pernicious anemia — where your stomach c...
- What is cyanocobalamin actually used for?
- The injection goes directly into a muscle or under the skin, bypassing the gut entirely — which makes it the most reliable option, especially for pernicious anemia, where lifelong...
- What's the difference between the shot and the nasal spray?
Patient education
Supplement & herbal interactions
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💊 What it looks like
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🧪 Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
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15 mg / 1 mL
UNII LKG8494WBH
Benzyl alcohol is a clear liquid used as a preservative and solvent in medicines. It helps prevent bacterial and fungal growth and dissolves other ingredients to create uniform liquid formulations.
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UNII QTT17582CB
A strong acid used to adjust and maintain the proper pH level in liquid medicines, ensuring stability and preventing breakdown of active ingredients.
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9 mg / 1 mL
UNII 451W47IQ8X
Sodium chloride is common table salt. It's used in medicines as a buffer to maintain proper pH, as a filler to add bulk, or to adjust the osmotic balance in liquid formulations.
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UNII 55X04QC32I
A strong alkaline chemical used to adjust and maintain the pH balance of liquid medicines. It helps keep the medicine stable and ensures it stays effective during storage.
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UNII 059QF0KO0R
Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
5 inactive ingredients listed in the exact product block matched to this NDC.
Where does this data come from?
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
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💲 Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per each | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | Not in the retail survey — common for institutional, discontinued, or low-volume packs. | |
| Medicaid paysCMS SDUD · 12 mo | No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data. | |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
Where does this data come from?
🔁 Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Cyanocobalamin 1000 ug/mL 00143-9619-10 | Hikma | 10 vials | $0.328 | AP | Availability likely | — |
| Cyanocobalamin 1000 ug/mL 69680-0121-05 | Vitruvias | 5 vials | $0.549 | AP | Availability likely | — |
| cyanocobalamin 1000 ug/mL 70710-1665-01 | Zydus | 1 vial | $0.761 | AP | Availability likely | — |
| Cyanocobalamin 1000 ug/mL 00143-9620-10 | Hikma | 10 vials | $0.777 | AP | Availability likely | — |
| Cyanocobalamin 1000 ug/mL 69680-0113-99 | Vitruvias | 10 vials | $0.777 | AP | Availability likely | — |
| cyanocobalamin 1000 ug/mL 70069-0172-10 | Somerset | 10 vials | $0.777 | AP | Availability likely | — |
| Cyanocobalamin 1000 ug/mL 71288-0301-11 | Meitheal | 10 vials | $0.777 | AP | Availability likely | — |
| Cyanocobalamin 1000 ug/mL 00517-0130-01 | American | 1 vial | $0.794 | AP | Availability likely | — |
| Cyanocobalamin 1000 ug/mL 71288-0302-30 | Meitheal | 1 vial | $0.794 | AP | Availability likely | — |
| cyanocobalamin 1000 ug/mL 70710-1664-06 | Zydus | 10 vials | $0.819 | AP | Availability likely | — |
| cyanocobalamin 1000 ug/mL 70710-1663-07 | Zydus | 25 vials | $1.491 | AP | Availability likely | — |
| Cyanocobalamin 1000 ug/mL 00143-9621-25 | Hikma | 25 vials | $1.494 | AP | Availability likely | — |
| Cyanocobalamin 1000 ug/mL 00517-0031-25 | American | 25 vials | $1.494 | AP | Availability likely | — |
| Cyanocobalamin 1000 ug/mL 25021-0502-01 | Sagent | 25 vials | $1.494 | AP | Availability likely | — |
| Cyanocobalamin 1000 ug/mL 63323-0044-01 | Fresenius | 25 vials | $1.494 | AP | Availability likely | — |
| Cyanocobalamin 1000 ug/mL 68001-0542-60 | BluePoint | 25 vials | $1.494 | AP | Availability likely | — |
| Cyanocobalamin 1000 ug/mL 68001-0640-60 | BluePoint | 25 vials | $1.494 | AP | Availability likely | — |
| cyanocobalamin 1000 ug/mL 70069-0005-10 | Somerset | 25 vials | $1.494 | AP | Availability likely | — |
| Cyanocobalamin 1000 ug/mL 70512-0840-25 | SOLA | 25 vials | $1.494 | AP | Availability likely | — |
| Cyanocobalamin 1000 ug/mL 71288-0300-92 | Meitheal | 25 vials | $1.494 | AP | Availability likely | — |
| Cyanocobalamin 1000 ug/mL 71288-0303-02 | Meitheal | 25 vials | $1.494 | AP | Availability likely | — |
| Cyanocobalamin 1000 ug/mL 72603-0650-25 | NorthStar | 25 vials | $1.494 | AP | Availability likely | — |
| Cyanocobalamin 1000 ug/mL 00517-0032-25 | American | 25 vials | $2.134 | AP | Availability likely | — |
| Cyanocobalamin 1000 ug/mL 69680-0112-10 | Vitruvias | 10 vials | $2.909 | AP | Availability likely | — |
| Cyanocobalamin 1000 ug/mL 00404-9783-30 | Henry | 1 vial | — | AP | FDA listed | — |
| Cyanocobalamin 1000 ug/mL 00404-9786-10 | Henry | 1 vial | — | AP | FDA listed | — |
| Cyanocobalamin 1000 ug/mL 50090-6229-00 | A-S | 25 vials | — | AP | FDA listed | — |
| Cyanocobalamin 1000 ug/mL 51662-1394-01 | HF | 30 ml | — | AP | FDA listed | — |
| Cyanocobalamin 1000 ug/mL 51662-1440-01 | HF | 10 ml | — | AP | FDA listed | — |
| Cyanocobalamin 1000 ug/mL 51662-1647-03 | HF | 25 pouches | — | AP | FDA listed | — |
| Cyanocobalamin 1000 ug/mL 51662-1703-03 | HF | 10 pouches | — | AP | FDA listed | — |
| Cyanocobalamin 1000 ug/mL 55150-0364-01 | AuroMedics | 1 vial | — | AP | FDA listed | — |
| Cyanocobalamin 1000 ug/mL 68083-0449-25 | Gland | 25 vials | — | AP | FDA listed | — |
| cyanocobalamin 1000 ug/mL 68083-0561-25 | Gland | 25 vials | — | AP | FDA listed | — |
| cyanocobalamin 1000 ug/mL 68083-0562-01 | Gland | 1 vial | — | AP | FDA listed | — |
| Cyanocobalamin 1000 ug/mL 70069-0171-05 | Somerset | 5 vials | — | AP | FDA listed | — |
| Cyanocobalamin 1000 ug/mL 70756-0635-10 | Lifestar | 10 vials | — | AP | FDA listed | — |
| Cyanocobalamin 1000 ug/mL 70756-0636-10 | Lifestar | 10 vials | — | AP | FDA listed | — |
| Cyanocobalamin 1000 ug/mL 70756-0637-05 | Lifestar | 5 vials | — | AP | FDA listed | — |
| cyanocobalamin 1000 ug/mL 70771-1688-07 | Zydus | 25 vials | — | AP | FDA listed | — |
| cyanocobalamin 1000 ug/mL 70771-1689-06 | Zydus | 10 vials | — | AP | FDA listed | — |
| cyanocobalamin 1000 ug/mL 70771-1690-01 | Zydus | 1 vial | — | AP | FDA listed | — |
| cyanocobalamin 1000 ug/mL 76420-0075-25 | Asclemed | 25 vials | — | AP | FDA listed | — |
| Cyanocobalamin 1000 ug/mL 76420-0111-25 | Asclemed | 25 vials | — | AP | FDA listed | — |
| Cyanocobalamin 1000 ug/mL 76420-0618-25 | Asclemed | 25 vials | — | AP | FDA listed | — |
| cyanocobalamin 1000 ug/mLthis 85766-0029-25 | Sportpharm | 25 vials | — | AP | FDA listed | — |
| Cyanocobalamin 1000 ug/mL 87188-0111-90 | Plano | 25 vials | — | AP | FDA listed | — |
| cyanocobalamin 1000 ug/mL 87188-0112-01 | Plano | 1 vial | — | AP | FDA listed | — |
| cyanocobalamin 1000 ug/mL 87188-0113-01 | Plano | 1 vial | — | AP | FDA listed | — |
Where does this data come from?
⏳ Availability & generic status
This product is an FDA-approved generic. Other versions of the same drug are listed under Therapeutic equivalents, least expensive first.
Where does this data come from?
🔬 Reported adverse events (FAERS)
Top reported reactions
Age at onset
Reporter sex
Serious outcomes
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📦 Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Status |
|---|---|---|---|
| 85766-0029-25 You're viewing this | 25 VIAL in 1 CARTON (85766-029-25) / 1 mL in 1 VIAL (85766-029-01) | 2025-08-07 | Active |
🧭 About this NDC listing & data coverage
What data is (and isn’t) available for this NDC — tap to expand
| NDC identity (package / product / labeler codes) | ✓ Available |
| Labeler | ✓ Available |
| Product & package description | ✓ Available |
| Marketing category & status | ✓ Available |
| Active ingredient / dosage form / route | ✓ Available |
| FDA label (SPL via DailyMed) | ✓ Available |
| Package photos | ✓ Available |
| Inactive ingredients (structured) | ✓ Available |
| NADAC pharmacy acquisition price (CMS) | — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey. |
| Orange Book / therapeutic-equivalence data | ✓ Available |
| HCPCS J-code billing crosswalk | — Not published for this NDC Most self-administered / retail products have no J-code — that is normal. |
| Medicaid utilization (CMS SDUD) | — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold. |
Questions about this listing
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📄 Full prescribing information FDA SPL
🎯 Indications and Usage ▾
INDICATIONS AND USAGE Cyanocobalamin is indicated for Vitamin B 12 deficiencies due to malabsorption which may be associated with the following conditions: Addisonian (pernicious) anemia Gastrointestinal pathology, dysfunction, or surgery, including gluten enteropathy or sprue, small bowel bacterial overgrowth, total or partial gastrectomy Fish tapeworm infestation Malignancy of pancreas or bowel Folic acid deficiency It may be possible to treat the underlying disease by surgical correction of anatomic lesions leading to small bowel bacterial overgrowth, expulsion of fish tapeworm, discontinuation of drugs leading to vitamin malabsorption (see Drug/Laboratory Test Interactions ), use of a gluten-free diet in nontropical sprue, or administration of antibiotics in tropical sprue.
Such measures remove the need for long-term administration of cyanocobalamin. Requirements of Vitamin B 12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with oral supplementation. Cyanocobalamin injection is also suitable for the Vitamin B 12 absorption test (Schilling test).
⏱️ Dosage and Administration ▾
DOSAGE AND ADMINISTRATION Avoid using the intravenous route. Use of this product intravenously will result in almost all of the vitamin being lost in the urine. Pernicious Anemia Parenteral Vitamin B 12 is the recommended treatment and will be required for the remainder of the patient's life.
The oral form is not dependable. A dose of 100 mcg daily for six or seven days should be administered by intramuscular or deep subcutaneous injection. If there is clinical improvement and if a reticulocyte response is observed, the same amount may be given on alternate days for seven doses, then every three to four days for another two to three weeks.
By this time hematologic values should have become normal. This regimen should be followed by 100 mcg monthly for life. Folic acid should be administered concomitantly if needed.
Patients with Normal Intestinal Absorption Where the oral route is not deemed adequate, initial treatment similar to that for patients with pernicious anemia may be indicated depending on the severity of the deficiency. Chronic treatment should be with an oral B 12 preparation. If other vitamin deficiencies are present, they should be treated.
Schilling Test The flushing dose is 1,000 mcg. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
⛔ Contraindications ▾
CONTRAINDICATIONS Sensitivity to cobalt and/or Vitamin B 12 is a contraindication.
⚠️ Warnings ▾
WARNINGS This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum.
Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration. Patients with early Leber's disease (hereditary optic nerve atrophy) who were treated with cyanocobalamin suffered severe and swift optic atrophy.
Hypokalemia and sudden death may occur in severe megaloblastic anemia which is treated intensely. Anaphylactic shock and death have been reported after parenteral Vitamin B 12 administration. An intradermal test dose is recommended before cyanocobalamin injection is administered to patients suspected of being sensitive to this drug.
This product contains benzyl alcohol. Benzyl alcohol has been reported to be associated with a fatal ''Gasping Syndrome'' in premature infants.
🤒 Adverse Reactions ▾
ADVERSE REACTIONS Generalized Anaphylactic shock and death have been reported with administration of parenteral Vitamin B 12 (see WARNINGS ). Cardiovascular Pulmonary edema and congestive heart failure early in treatment; peripheral vascular thrombosis. Hematological Polycythemia vera. Gastrointestinal Mild transient diarrhea. Dermatological Itching; transitory exanthema. Miscellaneous Feeling of swelling of entire body.
🤰 Pregnancy ▾
Pregnancy Adequate and well-controlled studies have not been done in pregnant women. However, Vitamin B 12 is an essential vitamin and requirements are increased during pregnancy. Amounts of Vitamin B 12 that are recommended by the Food and Nutrition Board, National Academy of Science-National Research Council for pregnant women (4 mcg daily) should be consumed during pregnancy.
🧒 Pediatric Use ▾
Pediatric Use Intake in children should be in the amount (0.5 to 3 mcg daily) recommended by the Food and Nutrition Board, National Academy of Science-National Research Council.
🆘 Overdosage ▾
OVERDOSAGE No overdosage has been reported with this drug.
🧬 Clinical Pharmacology ▾
CLINICAL PHARMACOLOGY Vitamin B 12 is essential to growth, cell reproduction, hematopoiesis, nucleoprotein and myelin synthesis. Cyanocobalamin is quantitatively and rapidly absorbed from intramuscular and subcutaneous sites of injection; the plasma level of the compound reaches its peak within one hour after intramuscular injection. Absorbed Vitamin B 12 is transported via specific B 12 binding proteins, transcobalamin I and II to the various tissues.
The liver is the main organ for Vitamin B 12 storage. Within 48 hours after injection of 100 or 1,000 mcg of Vitamin B 12 , 50 to 98% of the injected dose may appear in the urine. The major portion is excreted within the first eight hours.
Intravenous administration results in even more rapid excretion with little opportunity for liver storage. Gastrointestinal absorption of Vitamin B 12 depends on the presence of sufficient intrinsic factor and calcium ions. Intrinsic factor deficiency causes pernicious anemia, which may be associated with subacute combined degeneration of the spinal cord.
Prompt parenteral administration of Vitamin B 12 prevents progression of neurologic damage. The average diet supplies about 5 to 15 mcg/day of Vitamin B 12 in a protein-bound form that is available for absorption after normal digestion. Vitamin B 12 is not present in foods of plant origin, but is abundant in foods of animal origin.
In people with normal absorption, deficiencies have been reported only in strict vegetarians who consume no products of animal origin (including no milk products or eggs). Vitamin B 12 is bound to intrinsic factor during transit through the stomach; separation occurs in the terminal ileum in the presence of calcium, and Vitamin B 12 enters the mucosal cell for absorption. It is then transported by the transcobalamin binding proteins.
A small amount (approximately 1% of the total amount ingested) is absorbed by simple diffusion, but this mechanism is adequate only with very large doses. Oral absorption is considered too undependable to rely on in patients with pernicious anemia or other conditions resulting in malabsorption of Vitamin B 12 . Cyanocobalamin is the most widely used form of Vitamin B 12 , and has hematopoietic activity apparently identical to that of the antianemia factor in purified liver extract.
Hydroxocobalamin is equally as effective as cyanocobalamin, and they share the cobalamin molecular structure.
📦 How Supplied / Storage and Handling ▾
HOW SUPPLIED 1 mL multiple dose vial (NDC 85766-029-01 relabeled from NDC 70069-005-01), packaged 25 vials per tray (NDC 85766-029-25 relabeled from NDC 70069-005-10). Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. PROTECT FROM LIGHT Use only if solution is clear and seal intact.
For Product Inquiry call 1-800-417-9175 Distributed by: Sportpharm LLC 379 Van Ness Ave 1401, Torrance, CA 90501 Relabeled by: Enovachem PHARMACEUTICALS Torrance, CA 90501
📋 Description ▾
DESCRIPTION Cyanocobalamin Injection, USP is a sterile solution of cyanocobalamin for intramuscular or subcutaneous use. Each mL contains 1,000 mcg cyanocobalamin; sodium chloride 0.9%; benzyl alcohol 1.5%; Water for Injection q.s.; Hydrochloric acid and/or sodium hydroxide for pH adjustment if necessary (4.5-7.0). Cyanocobalamin appears as dark, red crystals or as an amorphous or crystalline, red powder.
It is very hygroscopic in the anhydrous form, and sparingly soluble in water (1:80). It is stable to autoclaving for short periods at 121°C. The Vitamin B 12 coenzymes are very unstable in light.
The chemical name is 5,6-dimethyl-benzimidazolyl cyanocobamide. The cobalt content is 4.34%. The structural formula is represented below: Molecular Structure
💬 Information for Patients ▾
Information for Patients Patients with pernicious anemia should be instructed that they will require monthly injections of Vitamin B 12 for the remainder of their lives. Failure to do so will result in return of the anemia and in development of incapacitating and irreversible damage to the nerves of the spinal cord. Also, patients should be warned about the danger of taking folic acid in place of Vitamin B 12 , because the former may prevent anemia but allow progression of subacute combined degeneration.
A vegetarian diet which contains no animal products (including milk products or eggs) does not supply any Vitamin B 12 . Patients following such a diet should be advised to take oral Vitamin B 12 regularly. The need for Vitamin B 12 is increased by pregnancy and lactation.
Deficiency has been recognized in infants of vegetarian mothers who were breast fed, even though the mothers had no symptoms of deficiency at the time. Contains no more than 57 mcg/L of aluminum.