FDA-filed SPL labeling · retrieved through openFDA

Cyanocobalamin

Cyanocobalamin is a prescription form of vitamin B12 used to treat or prevent vitamin B12 deficiency, including deficiency caused by pernicious anemia, poor absorption, diet, or certain medications.

Brand names DodexNascobalDodex InjectableCoco12Non-proprietary name +2 more
Drug class ⓘ Vitamin B12
Rx/OTC Forms 3 Routes Intramuscular, Subcutaneous · Intramuscular; Subcutaneous · Intramuscular · Nasal +2
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 34 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveDec 20, 2024
Clinical labels in scope ⓘ34
AvailabilityRx/OTC
Earliest approval/marketing year ⓘ1947
FDA-listed product records ⓘ127
Boxed warningNone found in compared labels
How we combine label and product data →
✓No current FDA shortage listed · checked Sep 20, 2026 🚨Recall on record · 2
Other forms & routes:
Injection Nasal
⭐ Cyanocobalamin at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Cyanocobalamin is a prescription vitamin B12 used to treat or prevent B12 deficiency from causes like pernicious anemia, poor absorption, or certain medical conditions. Injections are given by a healthcare provider and are often lifelong for pernicious anemia; nasal spray forms are used once weekly and require regular blood level monitoring. Always follow your prescriber's schedule and report any new symptoms — especially vision changes, muscle weakness, or signs of allergic reaction — right away.
How we write & review this content — our editorial policy →

📖 Cyanocobalamin: Patient Information Guide

A plain-language walkthrough of Cyanocobalamin — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for▾

Cyanocobalamin is a prescription vitamin B12 used to treat or prevent B12 deficiency across several product types, routes, and brands. Uses vary by product:

  • Cyanocobalamin injection treats vitamin B12 deficiency caused by conditions that impair absorption, including pernicious anemia (Addisonian anemia), gastrointestinal disease, dysfunction or surgery (such as gastrectomy or sprue), fish tapeworm infestation, malignancy of the pancreas or bowel, and folic acid deficiency
  • Cyanocobalamin injection is also suitable for the vitamin B12 absorption test (Schilling test)
  • Nascobal nasal spray is used for B12 maintenance therapy in adults with pernicious anemia who are in remission after intramuscular therapy and have no nervous system involvement
  • Nascobal and cyanocobalamin nasal spray treat B12 deficiency caused by diet, drugs, or malabsorption that is not due to pernicious anemia
  • Nascobal and cyanocobalamin nasal spray are used to prevent B12 deficiency in adults whose requirements exceed normal levels
  • Nasal spray forms should not be used for the Schilling test; their long-term benefit after correction of a temporary deficiency has not been established
  • Coco12 topical product is used for skin preparation prior to injection
⚙️How it works▾

Inside the body, cyanocobalamin is converted into an active coenzyme form of vitamin B12. This coenzyme is essential for two key reactions: converting a compound called methylmalonate into succinate (important for energy metabolism), and helping produce methionine from homocysteine — a reaction that also requires folate. Without enough active B12, folate gets locked in an inactive storage form and can't support healthy red blood cell production, which leads to a type of anemia called megaloblastic anemia. B12 also helps maintain certain enzyme systems involved in fat, carbohydrate, and protein metabolism.

💊How it's taken▾

How cyanocobalamin is taken depends on the product and condition being treated — always follow your prescriber's instructions exactly. Key points:

  • Injection (intramuscular or subcutaneous): Administered by a healthcare provider; never given intravenously. The schedule is tailored to your condition — pernicious anemia typically requires lifelong injections. The Non-proprietary name product is not intended for self-administration.
  • Nascobal and cyanocobalamin nasal spray: One spray into one nostril once weekly. Administer at least one hour before or after hot foods or liquids. B12 blood levels are monitored one month after starting and every 3–6 months thereafter. If levels drop persistently, your doctor may increase the dose or switch you to injections.
🤒Side effects — in detail▾

The most common side effects reported with cyanocobalamin include:

  • Headache
  • Nausea
  • Infection (such as sore throat or common cold)
  • Weakness or fatigue
  • Numbness or tingling (paresthesia)
  • Tongue soreness or inflammation (glossitis)
  • Runny or stuffy nose (rhinitis)

Serious reactions — including severe allergic reaction (anaphylaxis), dangerously low potassium (hypokalemia), and sudden death in cases of severe megaloblastic anemia treated intensely — have been reported. Seek emergency help immediately if you experience difficulty breathing, swelling, or collapse.

⚠️Warnings & precautions▾
  • Leber's disease: Patients with this hereditary optic nerve condition must not use cyanocobalamin — it has caused rapid, severe vision loss. A different B12 form (such as hydroxocobalamin) should be used instead.
  • Severe allergic reactions: Anaphylactic shock and death have been reported after injectable B12. A test dose may be given before starting nasal spray in patients who have never tolerated injectable cyanocobalamin.
  • Low potassium and sudden death: Intensively treating severe megaloblastic anemia with B12 can cause potassium levels to drop dangerously. Potassium and platelet counts must be monitored during therapy.
  • Masking folate deficiency: High B12 doses can improve blood counts even when the real problem is folate deficiency, hiding a diagnosis that still needs treatment. Both B12 and folate levels should be checked before starting therapy.
  • Polycythemia vera: B12 deficiency can suppress signs of this blood disorder. Starting B12 therapy may unmask it — patients showing signs should be evaluated further.
  • Benzyl alcohol and aluminum in injectables: Some injectable products contain benzyl alcohol (linked to fatal reactions in premature infants) or aluminum (which can accumulate to toxic levels in patients with impaired kidney function, especially premature newborns).
🔀What it interacts with▾

Cyanocobalamin has at least one important drug interaction to know about:

  • Chloramphenicol (an antibiotic): This drug may reduce how well cyanocobalamin works when used to treat anemia. If you take both, your doctor should monitor your response and may need to switch therapies.

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it▾
  • Do not use cyanocobalamin if you are allergic to cobalt, vitamin B12, or any ingredients in the product
  • Do not use cyanocobalamin if you have Leber's disease (hereditary optic nerve damage) — it can cause rapid, severe vision loss
  • Tell your doctor if you are pregnant — vitamin B12 requirements increase during pregnancy
  • Vitamin B12 passes into breast milk; discuss with your doctor if you are breastfeeding
  • Safety and effectiveness in children have not been established
  • Older adults (65+) have not been studied in large numbers, but no differences in response have been identified in clinical experience
  • Patients with impaired kidney function — especially premature newborns — may be at risk of aluminum toxicity from certain injectable formulations
  • Some injectable products contain benzyl alcohol, which is associated with serious and potentially fatal reactions in premature infants
  • If you have active nasal congestion, allergic rhinitis, or an upper respiratory infection, delay starting nasal spray forms until symptoms resolve
📡Pharmacodynamics — effects in the body▾

Intramuscular administration of vitamin B12 can completely reverse the blood (megaloblastic anemia) and gastrointestinal symptoms of B12 deficiency. Improvement in neurological symptoms depends on how long and how severe the nerve damage was, though further progression is stopped right away with treatment. In people with pernicious anemia, once-weekly intranasal B12 therapy has been shown to consistently raise pre-dose B12 blood levels compared to levels seen after intramuscular dosing.

🔬Pharmacokinetics — how your body processes it▾

When taken by mouth, vitamin B12 binds to a protein called intrinsic factor in the stomach and is absorbed in the lower small intestine (terminal ileum) — only about 1% is absorbed by simple diffusion without intrinsic factor, and only in very large amounts. After nasal spray administration, peak blood concentrations are reached in roughly 1 to 1.25 hours. Once in the bloodstream, B12 is carried by a protein called transcobalamin II and stored mainly in the liver and bone marrow. The body retains a high proportion of smaller intramuscular doses, but retention drops significantly at larger doses; excess unbound B12 is quickly cleared through the urine. A small amount of B12 is recycled daily through bile into the digestive tract and reabsorbed.

📦How to store it▾

Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) . PROTECT FROM LIGHT.

📄 Written from Cyanocobalamin’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Cyanocobalamin — the kind of thing our pharmacy team would talk through with you at the counter.

What is cyanocobalamin actually used for? ▾
It's a prescription form of vitamin B12, used when your body can't get enough B12 on its own. That can happen because of a condition called pernicious anemia — where your stomach can't make the protein needed to absorb B12 — or because of digestive surgery, certain diseases, or some medications that interfere with absorption. The goal is to restore your B12 levels and prevent problems with your blood and nerves.
What's the difference between the shot and the nasal spray? ▾
The injection goes directly into a muscle or under the skin, bypassing the gut entirely — which makes it the most reliable option, especially for pernicious anemia, where lifelong injections are usually needed. The nasal spray (Nascobal and cyanocobalamin nasal spray) is a once-weekly option that works well for maintenance in people whose pernicious anemia is already under control with shots and who don't have nerve damage. Your doctor will choose based on your specific situation.
How should I use the nasal spray correctly? ▾
Use it in one nostril once a week. The important thing to know is timing — use it at least an hour before or an hour after any hot food or drinks, because heat can affect how well it's absorbed. Also, if you have a stuffy nose, a cold, or allergies acting up, hold off until those symptoms clear before using it. Your doctor will check your B12 blood levels a month after you start, and then every few months to make sure it's working.
What side effects should I watch out for? ▾
Most people tolerate cyanocobalamin well. The most commonly reported effects include headache, nausea, fatigue, tingling or numbness, a sore tongue, and nasal symptoms like a runny nose with the spray. These are usually mild. What you do want to call about right away is any sign of a serious allergic reaction — trouble breathing, swelling of your face or throat, or feeling like you might pass out. That's rare but can be serious.
Is it safe to take if I'm pregnant or breastfeeding? ▾
Vitamin B12 is actually an essential nutrient during pregnancy, and your requirements go up when you're expecting. The labeling notes that data on the nasal spray specifically in pregnancy is limited, but B12 itself is considered necessary. B12 does pass into breast milk, and it's not considered to pose more than minimal risk to nursing babies. That said, always let your doctor know you're pregnant or breastfeeding so they can make sure your treatment plan is right for you.
Are there any medications that can interfere with cyanocobalamin? ▾
One key interaction to know: an antibiotic called chloramphenicol can reduce how well cyanocobalamin works when you're using it to treat anemia. If you're on both, your doctor should monitor your response more closely. Also, some drugs and digestive conditions can cause B12 deficiency in the first place — so always give your doctor a full list of everything you're taking.
Is Cyanocobalamin available over the counter? ▾
Both — Cyanocobalamin is sold both over the counter and by prescription, according to its FDA labeling. Lower strengths or certain forms are often available without a prescription, while higher strengths or specialized forms still require one. Ask your pharmacist which version is right for you.
When was Cyanocobalamin first available? ▾
Cyanocobalamin has been available in the United States since at least 1947, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Cyanocobalamin? ▾
Cyanocobalamin is supplied by 45 manufacturers listed in the FDA NDC Directory, including Somerset Therapeutics, LLC, Vitruvias Therapeutics, Hikma Pharmaceuticals USA Inc..

💬 Answers drafted from Cyanocobalamin’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

🌿Drug & Supplement CheckerCyanocobalamin vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Cyanocobalamin NDCs & costs 🅰️Browse Drugs A–ZLook up any medication

💊 How Cyanocobalamin comes

Cyanocobalamin is available in 3 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Injection

Into a muscle · Under the skin
Brands Dodex Injectable Non-proprietary name Vitamin Deficiency System
How this form is used
What it may be used for
  • Treats vitamin B12 deficiency caused by pernicious anemia (Addisonian anemia)
  • Treats B12 deficiency due to gastrointestinal disease, dysfunction, or surgery
  • Treats B12 deficiency from fish tapeworm infestation, pancreatic or bowel malignancy, or folic acid deficiency
  • Vitamin Deficiency System injection can also be used for the vitamin B12 absorption test (Schilling test)
Important instructions
  • Give by intramuscular or subcutaneous injection only — never intravenously (into a vein)
  • Non-proprietary name injection should be administered by a licensed healthcare professional under appropriate medical supervision — it is not intended for self-administration
  • Inspect the solution before use; do not use if cloudy, discolored, or if the container is damaged
  • For pernicious anemia, parenteral B12 therapy is typically required for the remainder of the patient's life — follow your prescriber's schedule exactly
Available strengths 2 strengths
1000 mcg/mL 2 mg/mL
103 FDA-listed product records ⓘ

Nasal spray

In the nose
Brands Nascobal
How this form is used
What it may be used for
  • Nascobal is used for vitamin B12 maintenance therapy in adults with pernicious anemia in remission after intramuscular B12 therapy, with no nervous system involvement
  • Nascobal treats adult B12 deficiency caused by diet, drugs, or malabsorption that is not due to pernicious anemia
  • Nascobal and cyanocobalamin nasal spray are used to prevent B12 deficiency in adults whose B12 requirements are higher than normal
  • Nascobal and cyanocobalamin nasal spray should not be used for the vitamin B12 absorption test (Schilling test)
Important instructions
  • Nascobal and cyanocobalamin nasal spray are sprayed into one nostril once weekly
  • Use at least one hour before or one hour after eating or drinking hot foods or liquids
  • Do not use Nascobal or cyanocobalamin nasal spray during active nasal congestion, allergic rhinitis, or upper respiratory infection — wait until symptoms resolve
  • Your doctor will check your B12 blood levels one month after starting, then every 3 to 6 months — if levels remain low, your prescriber may adjust the dose or switch to a different therapy
Available strengths 1 strength
500 mcg
4 FDA-listed product records ⓘ

Topical cream, ointment or gel

On the skin
Brands Coco12
How this form is used
What it may be used for
  • Coco12 is used for preparation of the skin prior to an injection
Important instructions
  • Coco12 is for external use only
  • Keep Coco12 away from fire or flame — it is flammable
Available strengths 1 strength
0.05 g/0.05 g
1 FDA-listed product record ⓘ

📊 Cyanocobalamin across the U.S. market

How Cyanocobalamin appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

3
Dose forms ⓘ
45
Manufacturers
7
Brand names
127
FDA-listed product records ⓘ
1947
First marketed ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (18) · Kit (1) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Somerset Therapeutics, LLC7%
Vitruvias Therapeutics7%
Hikma Pharmaceuticals USA Inc.7%
HF Acquisition Co LLC, DBA HealthFirst6%
Meitheal Pharmaceuticals Inc.5%
American Regent, Inc.5%
Other makers62%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Cyanocobalamin is used

A general measure of how commonly Cyanocobalamin is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Cyanocobalamin is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

1,095,564
Medicaid prescriptions filled (Q1–Q4 2025)
$14.6M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Cyanocobalamin prescribed? Of the 1,596 medications we measure, Cyanocobalamin ranks #166 by Medicaid prescriptions — more than 90% of them.

Where Cyanocobalamin ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #166 of 1,596
#161 Epinephrine Injection 1,101,355 Rx #162 Clobetasol 1,099,263 Rx #163 Lithium 1,098,757 Rx #164 Lithium Carbonate 1,097,615 Rx #165 Fenofibrate 1,097,185 Rx #166 Cyanocobalamin 1,095,564 Rx #167 Clobetasol Topical 1,093,267 Rx #168 Cyanocobalamin Injecti... 1,087,734 Rx #169 Nifedipine 1,079,242 Rx #170 Cariprazine 1,076,596 Rx #171 Naltrexone 1,052,053 Rx

Utilization by Cyanocobalamin product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 1 mg/mL injectable solution is the most-dispensed Cyanocobalamin product — about 99% of these Medicaid prescriptions.

vitamin B12 1 MG/ML Injectable Solution Most dispensed

1,087,734 Medicaid prescriptions (Q1–Q4 2025) 99% of Cyanocobalamin prescriptions shown $10.9M gross reimbursement (before rebates) ≈ $10 per prescription (gross)

Summed across the 29 of 135 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 309594

vitamin B12 0.5 MG/ACTUAT Nasal Spray

7,830 Medicaid prescriptions (Q1–Q4 2025) <1% of Cyanocobalamin prescriptions shown $3.7M gross reimbursement (before rebates) ≈ $470 per prescription (gross)

Summed across the 2 of 6 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 861113

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Cyanocobalamin, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 31 of 141 listed Cyanocobalamin NDCs with Medicaid activity.

🔍 Compare Cyanocobalamin products

A representative set of FDA-listed product records for Cyanocobalamin — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 127 of 127 products — FDA National Drug Code Directory. See every product, package size and price: browse all 127 Cyanocobalamin NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Cyanocobalamin RxCUI 11248 12 dose forms · 49 strengths
  1. Dose form (SCDF) Chewable Tablet RxCUI 371648 No current FDA listing
    Clinical drug / strength (SCD) 0.5 MG RxCUI 2185309 1 MG RxCUI 198890 1.5 MG RxCUI 2682744 2.5 MG RxCUI 1486245 5 MG RxCUI 1804852
  2. Dose form (SCDF) Disintegrating Oral Tablet RxCUI 1291287 No current FDA listing
    Clinical drug / strength (SCD) 1 MG RxCUI 1374869 2 MG RxCUI 2714170 2.5 MG RxCUI 2735126 5 MG RxCUI 1291288
  3. Dose form (SCDF) Extended Release Oral Tablet RxCUI 371651 No current FDA listing
    Clinical drug / strength (SCD) 1 MG RxCUI 237776 1.5 MG RxCUI 240516 2 MG RxCUI 237777 5 MG RxCUI 1606305
  4. Dose form (SCDF) Injectable Solution RxCUI 371649 In current FDA listings
    Clinical drug / strength (SCD) 1 MG/ML RxCUI 309594 3 MG/ML RxCUI 1006047 5 MG/ML RxCUI 2001499
  5. Dose form (SCDF) Nasal Gel RxCUI 376662 No current FDA listing
    Clinical drug / strength (SCD) 0.005 MG/MG RxCUI 309611
  6. Dose form (SCDF) Nasal Spray RxCUI 378708 In current FDA listings
    Clinical drug / strength (SCD) 0.5 MG/ACTUAT RxCUI 861113
  7. Dose form (SCDF) Oral Capsule RxCUI 371646 No current FDA listing
    Clinical drug / strength (SCD) 1 MG RxCUI 245557 2 MG RxCUI 2171138 3 MG RxCUI 1245012 5 MG RxCUI 1653780
  8. Dose form (SCDF) Oral Film RxCUI 2745599 No current FDA listing
    Clinical drug / strength (SCD) 0.5 MG RxCUI 2745600
  9. Dose form (SCDF) Oral Lozenge RxCUI 375346 No current FDA listing
    Clinical drug / strength (SCD) 0.05 MG RxCUI 242347 0.1 MG RxCUI 199364 0.25 MG RxCUI 199374 0.5 MG RxCUI 199365 1 MG RxCUI 242698 2 MG RxCUI 200165 2.5 MG RxCUI 1437717 3 MG RxCUI 1246063
  10. Dose form (SCDF) Oral Solution RxCUI 348170 No current FDA listing
    Clinical drug / strength (SCD) 0.007 MG/ML RxCUI 105687 0.0667 MG/ML RxCUI 1112803 1 MG/ML RxCUI 1423423 3 MG/ML RxCUI 1488563 5 MG/ML RxCUI 1248737
  11. Dose form (SCDF) Oral Tablet RxCUI 371650 No current FDA listing
    Clinical drug / strength (SCD) 0.05 MG RxCUI 105686 0.1 MG RxCUI 309595 0.25 MG RxCUI 309604 0.5 MG RxCUI 313896 1 MG RxCUI 309593 2 MG RxCUI 244190 2.5 MG RxCUI 1245015
  12. Dose form (SCDF) Sublingual Tablet RxCUI 371652 No current FDA listing
    Clinical drug / strength (SCD) 0.5 MG RxCUI 636371 1 MG RxCUI 237779 2.5 MG RxCUI 198891 3 MG RxCUI 855213 5 MG RxCUI 199184 6 MG RxCUI 835519

Look up RxCUI 11248 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Dodex Nascobal Dodex Injectable Coco12 Non-proprietary name Vitamin Deficiency Injectable System - B12 Vitamin Deficiency System

🏭 Manufacturers & labelers

Somerset Therapeutics, LLC 9 Vitruvias Therapeutics 9 Hikma Pharmaceuticals USA Inc. 9 HF Acquisition Co LLC, DBA HealthFirst 7 Meitheal Pharmaceuticals Inc. 6 American Regent, Inc. 6 Lifestar Pharma LLC 6 A-S Medication Solutions 4 Henry Schein, Inc. 4 Fresenius Kabi USA, LLC 4 BluePoint Laboratories 4 Gland Pharma Limited 3 Zydus Lifesciences Limited 3 Euroapi France 3 UBI Pharma Inc. 3 SOLA Pharmaceuticals 3 Zydus Pharmaceuticals USA Inc. 3 Asclemed USA, Inc. 3 Plano Pharmaceuticals Inc. 3 Northstar Rx LLC. 3 Willow Birch Pharma, LLC 2 Willow Birch Pharma, Inc. 2 NorthStar RxLLC 2 Accord Healthcare, Inc. 2

…and 16 more on the FDA NDC directory.

RxNorm drug class

Cyanocobalamin belongs to the Vitamin B12 class.

Pharmacologic class Vitamin B12
Drug family (ATC) Vitamin B12 (cyanocobalamin and analogues)

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Dec 20, 2024
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Cyanocobalamin.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Cyanocobalamin after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
34
NDC products indexed
127
Distinct labelers/manufacturers represented
45
Linked representative label ⓘ
Vitruvias Therapeutics
Linked label effective
Dec 20, 2024
Composite sections available
17
Linked SPL Set ID
2117af8a-723f-4e2f-98a6-83ad2c423751
Linked SPL Document ID
7c3b0e85-bd17-4998-aaf4-1a873a357ab4
Open the linked representative label on DailyMed ↗

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 34 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Vitruvias Therapeutics is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.