Trimethoprim

Generic name: Pronounced as (trye meth' oh prim)
Brand names
  • Primsol®
  • Proloprim®
  • Trimpex®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 10/15/2017

Trimethoprim eliminates bacteria that cause urinary tract infections. It is used in combination with other drugs to treat certain types of pneumonia. It also is used to treat traveler's diarrhea. Antibiotics will not work for colds, flu, or other viral infections.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Trimethoprim comes as a tablet to take by mouth. It usually is taken one or two times a day. Trimethoprim may be taken with or without food. Follow the directions on your prescription label carefully, and ask your pharmacist or doctor to explain any part you do not understand. Take trimethoprim exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Before taking trimethoprim,

  • tell your doctor and pharmacist if you are allergic to trimethoprim, sulfa drugs, diuretics ('water pills', oral diabetes medications, or any other drugs.

  • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially phenytoin (Dilantin) and vitamins.

  • tell your doctor if you have or have ever had anemia or liver or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking trimethoprim, call your doctor immediately.

Take trimethoprim on an empty stomach, 1 hour before or 2 hours after meals. However, if you experience nausea, you may take trimethoprim with food.

Drink at least eight glasses of liquid (water, tea, coffee, soft drinks, milk, and fruit juice) every day.

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your dosing schedule. Do not take a double dose to make up for a missed one.

  • Trimethoprim may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • upset stomach

    • vomiting

    • diarrhea

  • If you experience any of the following symptoms, call your doctor immediately:

    • rash (hives)

    • itching

    • difficulty breathing or swallowing

    • sore throat

    • fever or chills

    • mouth sores

    • unusual bruising or bleeding

    • yellowing of the skin or eyes

    • paleness

    • joint aches

    • bluish-colored fingernails, lips, or skin

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to trimethoprim.

Do not let anyone else take your medication. Your prescription is probably not refillable. If you still have symptoms of infection after you finish the trimethoprim, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The serum concentration of Repaglinide can be increased when it is combined with Trimethoprim.
Montelukast Montelukast The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Montelukast.
Leflunomide Leflunomide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Trimethoprim can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Trimethoprim can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Trimethoprim.
Alendronate Alendronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Alendronic acid.
Candesartan Candesartan The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Candesartan.
Cilostazol Cilostazol Trimethoprim may decrease the excretion rate of Cilostazol which could result in a higher serum level.
Clopidogrel Clopidogrel The metabolism of Trimethoprim can be decreased when combined with Clopidogrel.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Fenofibrate Fenofibrate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Fenofibrate.
Guanfacine Guanfacine Trimethoprim may decrease the excretion rate of Guanfacine which could result in a higher serum level.
Magnesium Hydroxide Magnesium Hydroxide Trimethoprim may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Mycophenolate Mycophenolate Trimethoprim may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Nafarelin Nafarelin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Nafarelin.
Olsalazine Olsalazine Olsalazine may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Paregoric Paregoric The metabolism of Morphine can be decreased when combined with Trimethoprim.
Penbutolol Penbutolol The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Acebutolol.
Potassium Potassium Potassium may increase the excretion rate of Trimethoprim which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone Trimethoprim may decrease the excretion rate of Prednisone which could result in a higher serum level.
Ranitidine Ranitidine The serum concentration of Ranitidine can be increased when it is combined with Trimethoprim.
Reserpine Reserpine The serum concentration of Reserpine can be increased when it is combined with Trimethoprim.
Rizatriptan Rizatriptan Trimethoprim may decrease the excretion rate of Rizatriptan which could result in a higher serum level.
Sumatriptan Sumatriptan Trimethoprim may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus Tacrolimus Tacrolimus may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Triamcinolone Triamcinolone The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Triamcinolone.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection The metabolism of Trimethoprim can be decreased when combined with Fluconazole.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection Hydromorphone may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Levofloxacin Injection Levofloxacin Injection Trimethoprim may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Meperidine Injection Meperidine Injection Trimethoprim may decrease the excretion rate of Meperidine which could result in a higher serum level.
Metoclopramide Injection Metoclopramide Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Metoclopramide.
Metronidazole Injection Metronidazole Injection The metabolism of Trimethoprim can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The metabolism of Morphine can be decreased when combined with Trimethoprim.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Trimethoprim may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Trimethoprim.
Altretamine Altretamine Amphetamine may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Cyclosporine Cyclosporine Cyclosporine may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Ondansetron Ondansetron The metabolism of Ondansetron can be decreased when combined with Trimethoprim.
Enoxaparin Injection Enoxaparin Injection The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Enoxaparin.
Torsemide Torsemide The metabolism of Trimethoprim can be decreased when combined with Torasemide.
Olanzapine Olanzapine The metabolism of Trimethoprim can be decreased when combined with Olanzapine.
Alosetron Alosetron The metabolism of Alosetron can be decreased when combined with Trimethoprim.
Dofetilide Dofetilide Trimethoprim may decrease the excretion rate of Dofetilide which could result in a higher serum level.
Eprosartan Eprosartan The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Eprosartan.
Hydroxychloroquine Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Trimethoprim.
Meloxicam Meloxicam Trimethoprim may decrease the excretion rate of Meloxicam which could result in a higher serum level.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Risedronate Risedronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Risedronic acid.
Telmisartan Telmisartan The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Telmisartan.
Temozolomide Temozolomide Trimethoprim may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon Zaleplon Trimethoprim may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Anakinra Anakinra The metabolism of Trimethoprim can be increased when combined with Anakinra.
Trimipramine Trimipramine The metabolism of Trimipramine can be decreased when combined with Trimethoprim.
Etanercept Injection Etanercept Injection The metabolism of Trimethoprim can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Trimethoprim can be decreased when combined with Armodafinil.
Perindopril Perindopril Trimethoprim may increase the hyperkalemic activities of Perindopril.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Epinephrine Injection Epinephrine Injection The serum concentration of Epinephrine can be increased when it is combined with Trimethoprim.
Eplerenone Eplerenone Eplerenone may increase the excretion rate of Trimethoprim which could result in a lower serum level and potentially a reduction in efficacy.
Olmesartan Olmesartan The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Olmesartan.
Zonisamide Zonisamide Trimethoprim may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Adalimumab Injection Adalimumab Injection The metabolism of Trimethoprim can be increased when combined with Adalimumab.
Atomoxetine Atomoxetine Atomoxetine may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Atazanavir Atazanavir The metabolism of Trimethoprim can be decreased when combined with Atazanavir.
Almotriptan Almotriptan The metabolism of Almotriptan can be decreased when combined with Trimethoprim.
Eletriptan Eletriptan The metabolism of Trimethoprim can be decreased when combined with Eletriptan.
Mefloquine Mefloquine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Mefloquine is combined with Trimethoprim.
Rosuvastatin Rosuvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Rosuvastatin.
Aprepitant Aprepitant The metabolism of Trimethoprim can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine Trimethoprim may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine Memantine The serum concentration of Memantine can be increased when it is combined with Trimethoprim.
Tadalafil Tadalafil Trimethoprim may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Progesterone Progesterone The metabolism of Trimethoprim can be decreased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Trimethoprim.
Infliximab Injection Infliximab Injection The metabolism of Trimethoprim can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Trimethoprim can be decreased when combined with Oxandrolone.
Duloxetine Duloxetine Trimethoprim may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Tinidazole Tinidazole Trimethoprim may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Bosentan Bosentan The metabolism of Trimethoprim can be increased when combined with Bosentan.
Cefditoren Cefditoren Trimethoprim may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Trimethoprim.
Eszopiclone Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Trimethoprim.
Ganciclovir Ganciclovir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Ganciclovir.
Ribavirin Ribavirin Trimethoprim may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Valganciclovir Valganciclovir Trimethoprim may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole Voriconazole The metabolism of Trimethoprim can be decreased when combined with Voriconazole.
Adefovir Adefovir Adefovir may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Amphetamine may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Trimethoprim can be increased when combined with Peginterferon alfa-2b.
Ibandronate Ibandronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Ibandronate.
Ramelteon Ramelteon Trimethoprim may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Fentanyl Fentanyl Trimethoprim may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Pregabalin Pregabalin Pregabalin may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Felbamate Felbamate The metabolism of Trimethoprim can be decreased when combined with Felbamate.
Ranolazine Ranolazine Ranolazine may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Abatacept Injection Abatacept Injection The metabolism of Trimethoprim can be increased when combined with Abatacept.
Rasagiline Rasagiline Trimethoprim may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Imatinib Imatinib The metabolism of Trimethoprim can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The metabolism of Sitagliptin can be decreased when combined with Trimethoprim.
Varenicline Varenicline The serum concentration of Varenicline can be increased when it is combined with Trimethoprim.
Gefitinib Gefitinib The metabolism of Trimethoprim can be decreased when combined with Gefitinib.
Albuterol Albuterol Trimethoprim may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone Paliperidone Trimethoprim may decrease the excretion rate of Paliperidone which could result in a higher serum level.
Bortezomib Bortezomib The metabolism of Trimethoprim can be decreased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection The serum concentration of Clofarabine can be increased when it is combined with Trimethoprim.
Lubiprostone Lubiprostone Trimethoprim may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Oxaliplatin Injection Oxaliplatin Injection The serum concentration of Oxaliplatin can be increased when it is combined with Trimethoprim.
Aliskiren Aliskiren The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Aliskiren.
Pemetrexed Injection Pemetrexed Injection Trimethoprim may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Nabilone Nabilone The metabolism of Trimethoprim can be decreased when combined with Nabilone.
Sorafenib Sorafenib The metabolism of Trimethoprim can be decreased when combined with Sorafenib.
Dronabinol Dronabinol The metabolism of Dronabinol can be decreased when combined with Trimethoprim.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Trimethoprim.
Levocetirizine Levocetirizine Trimethoprim may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Trimethoprim may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Armodafinil Armodafinil The metabolism of Trimethoprim can be decreased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection Trimethoprim may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Ivermectin Ivermectin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Ivermectin.
Lenalidomide Lenalidomide Trimethoprim may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Nilotinib Nilotinib The metabolism of Trimethoprim can be decreased when combined with Nilotinib.
Raltegravir Raltegravir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Raltegravir.
Bexarotene Bexarotene The metabolism of Trimethoprim can be decreased when combined with Bexarotene.
Budesonide Budesonide Trimethoprim may decrease the excretion rate of Budesonide which could result in a higher serum level.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Doripenem Injection Doripenem Injection Trimethoprim may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine Etravirine The metabolism of Trimethoprim can be decreased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection Trimethoprim may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Desvenlafaxine Desvenlafaxine Trimethoprim may decrease the excretion rate of Desvenlafaxine which could result in a higher serum level.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Nebivolol Nebivolol The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Nebivolol.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Trimethoprim.
Leucovorin Injection Leucovorin Injection The therapeutic efficacy of Trimethoprim can be decreased when used in combination with Leucovorin.
Flecainide Flecainide The metabolism of Trimethoprim can be decreased when combined with Flecainide.
Certolizumab Injection Certolizumab Injection The metabolism of Trimethoprim can be increased when combined with Certolizumab pegol.
Levoleucovorin Injection Levoleucovorin Injection The therapeutic efficacy of Trimethoprim can be decreased when used in combination with Levoleucovorin.
Daptomycin Injection Daptomycin Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Daptomycin is combined with Trimethoprim.
Methylnaltrexone Injection Methylnaltrexone Injection Trimethoprim may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Midazolam Midazolam Trimethoprim may decrease the excretion rate of Midazolam which could result in a higher serum level.
Naltrexone Injection Naltrexone Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Naltrexone.
Dexrazoxane Injection Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Trimethoprim.
Milnacipran Milnacipran Trimethoprim may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Plerixafor Injection Plerixafor Injection Trimethoprim may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Sodium Phosphate Sodium Phosphate Sodium phosphate, monobasic may increase the hyperkalemic activities of Trimethoprim.
Fesoterodine Fesoterodine Trimethoprim may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Betaxolol Betaxolol The risk or severity of hyperkalemia can be increased when Betaxolol is combined with Trimethoprim.
Prasugrel Prasugrel Trimethoprim may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Trimethoprim.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Trimethoprim which could result in a lower serum level and potentially a reduction in efficacy.
Pralatrexate Injection Pralatrexate Injection Trimethoprim may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection Palonosetron may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Saxagliptin Saxagliptin Trimethoprim may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection Telavancin Injection Trimethoprim may decrease the excretion rate of Telavancin which could result in a higher serum level.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Trimethoprim.
Topotecan Topotecan Trimethoprim may decrease the excretion rate of Topotecan which could result in a higher serum level.
Golimumab Injection Golimumab Injection The metabolism of Trimethoprim can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Trimethoprim.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Trimethoprim.
Tocilizumab Injection Tocilizumab Injection The metabolism of Trimethoprim can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine The serum concentration of Dalfampridine can be increased when it is combined with Trimethoprim.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Trimethoprim.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Acetaminophen Injection Acetaminophen Injection Acetaminophen may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Ipilimumab Injection Ipilimumab Injection Trimethoprim may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Trimethoprim may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Azilsartan Azilsartan The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Azilsartan medoxomil.
Roflumilast Roflumilast Trimethoprim may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Linagliptin Linagliptin The serum concentration of Linagliptin can be increased when it is combined with Trimethoprim.
Potassium Iodide Potassium Iodide Potassium Iodide may increase the hyperkalemic activities of Trimethoprim.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Trimethoprim.
Abiraterone Abiraterone The metabolism of Trimethoprim can be decreased when combined with Abiraterone.
Rivaroxaban Rivaroxaban Trimethoprim may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor Ticagrelor The metabolism of Trimethoprim can be decreased when combined with Ticagrelor.
Ruxolitinib Ruxolitinib Trimethoprim may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Clobazam Clobazam Clobazam may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Vemurafenib Vemurafenib The metabolism of Trimethoprim can be decreased when combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Trimethoprim can be decreased when combined with Vismodegib.
Deferiprone Deferiprone Trimethoprim may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Naloxone Injection Naloxone Injection Trimethoprim may decrease the excretion rate of Naloxone which could result in a higher serum level.
Fondaparinux Injection Fondaparinux Injection Trimethoprim may decrease the excretion rate of Fondaparinux which could result in a higher serum level.
Iloprost Iloprost The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Iloprost.
Enzalutamide Enzalutamide The metabolism of Trimethoprim can be increased when combined with Enzalutamide.
Mirabegron Mirabegron Trimethoprim may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Regorafenib Regorafenib The metabolism of Trimethoprim can be decreased when combined with Regorafenib.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Trimethoprim.
Teduglutide Injection Teduglutide Injection Trimethoprim may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Alogliptin Alogliptin Trimethoprim may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Trimethoprim.
Pomalidomide Pomalidomide Trimethoprim may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Trimethoprim.
Canagliflozin Canagliflozin Trimethoprim may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Trimethoprim which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib Dabrafenib The metabolism of Trimethoprim can be decreased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Trimethoprim.
Trametinib Trametinib Trimethoprim may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Trimethoprim.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Trimethoprim.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Sofosbuvir Sofosbuvir Trimethoprim may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin Trimethoprim may increase the excretion rate of Dapagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast Apremilast The metabolism of Trimethoprim can be increased when combined with Apremilast.
Droxidopa Droxidopa Trimethoprim may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib Ceritinib The metabolism of Trimethoprim can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Trimethoprim can be increased when combined with Siltuximab.
Testosterone Injection Testosterone Injection Trimethoprim may decrease the excretion rate of Testosterone which could result in a higher serum level.
Oritavancin Injection Oritavancin Injection The metabolism of Trimethoprim can be decreased when combined with Oritavancin.
Edoxaban Edoxaban Trimethoprim may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Methamphetamine Methamphetamine Trimethoprim may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Tasimelteon Tasimelteon Trimethoprim may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Riociguat Riociguat The metabolism of Riociguat can be decreased when combined with Trimethoprim.
Secukinumab Injection Secukinumab Injection The metabolism of Trimethoprim can be increased when combined with Secukinumab.
Lenvatinib Lenvatinib The metabolism of Trimethoprim can be decreased when combined with Lenvatinib.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Trimethoprim.
Amiloride Amiloride Trimethoprim may increase the excretion rate of Amiloride which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan Macitentan Trimethoprim may decrease the excretion rate of Macitentan which could result in a higher serum level.
Penicillin G Procaine Injection Penicillin G Procaine Injection Trimethoprim may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Trimethoprim.
Ixazomib Ixazomib Trimethoprim may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lesinurad Lesinurad Trimethoprim may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection Trimethoprim may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
Selexipag Selexipag The metabolism of Selexipag can be decreased when combined with Trimethoprim.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Trimethoprim.
Furosemide Injection Furosemide Injection Trimethoprim may increase the excretion rate of Furosemide which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib Rucaparib The metabolism of Trimethoprim can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection Trimethoprim may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Trimethoprim.
Doxepin (Insomnia) Doxepin (Insomnia) Trimethoprim may decrease the excretion rate of Doxepin which could result in a higher serum level.
Deutetrabenazine Deutetrabenazine Trimethoprim may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Trimethoprim may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Safinamide Safinamide The metabolism of Trimethoprim can be decreased when combined with Safinamide.
Naldemedine Naldemedine Trimethoprim may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Midostaurin Midostaurin The metabolism of Trimethoprim can be decreased when combined with Midostaurin.
Enasidenib Enasidenib The metabolism of Trimethoprim can be decreased when combined with Enasidenib.
Benznidazole Benznidazole Trimethoprim may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin Trimethoprim may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Ertugliflozin Ertugliflozin Ertugliflozin may increase the excretion rate of Trimethoprim which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Trimethoprim.
Apalutamide Apalutamide The metabolism of Trimethoprim can be decreased when combined with Apalutamide.
Penicillamine Penicillamine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Penicillamine.
Avatrombopag Avatrombopag The metabolism of Trimethoprim can be increased when combined with Avatrombopag.
Baricitinib Baricitinib Trimethoprim may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine Trimethoprim may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Plazomicin Injection Plazomicin Injection Trimethoprim may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Trimethoprim.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Trimethoprim.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Trimethoprim.
Stiripentol Stiripentol The metabolism of Trimethoprim can be decreased when combined with Stiripentol.
Glasdegib Glasdegib The metabolism of Glasdegib can be decreased when combined with Trimethoprim.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Trimethoprim.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Trimethoprim.
Rifamycin Rifamycin The metabolism of Trimethoprim can be decreased when combined with Rifamycin.
Prucalopride Prucalopride Trimethoprim may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Trimethoprim can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Trimethoprim.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Trimethoprim.
Alpelisib Alpelisib The serum concentration of Trimethoprim can be decreased when it is combined with Alpelisib.
Cladribine Cladribine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Cladribine is combined with Trimethoprim.
Solriamfetol Solriamfetol The serum concentration of Solriamfetol can be increased when it is combined with Trimethoprim.
Triclabendazole Triclabendazole The metabolism of Trimethoprim can be decreased when combined with Triclabendazole.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Trimethoprim.
Pitolisant Pitolisant The serum concentration of Trimethoprim can be decreased when it is combined with Pitolisant.
Phenytoin Injection Phenytoin Injection The serum concentration of Trimethoprim can be decreased when it is combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The serum concentration of Trimethoprim can be decreased when it is combined with Fosphenytoin.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Trimethoprim.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Trimethoprim.
Cenobamate Cenobamate The serum concentration of Trimethoprim can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod The metabolism of Ozanimod can be decreased when combined with Trimethoprim.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Trimethoprim.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Trimethoprim.
Pralsetinib Pralsetinib The metabolism of Trimethoprim can be decreased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Trimethoprim can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives Trimethoprim may increase the excretion rate of Drospirenone which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine Viloxazine Trimethoprim may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Trimethoprim.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Indomethacin Indomethacin Indomethacin may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid Trimethoprim may decrease the excretion rate of Mefenamic acid which could result in a higher serum level.
Naproxen Naproxen The metabolism of Naproxen can be decreased when combined with Trimethoprim.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Isotretinoin Isotretinoin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Isotretinoin.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Floxuridine Floxuridine The metabolism of Trimethoprim can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Trimethoprim.
Metaxalone Metaxalone Trimethoprim may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection The risk or severity of adverse effects can be increased when Trimethoprim is combined with Methotrexate.
Primidone Primidone The metabolism of Primidone can be decreased when combined with Trimethoprim.
Methsuximide Methsuximide The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Methsuximide.
Chlorpromazine Chlorpromazine Trimethoprim may decrease the excretion rate of Chlorpromazine which could result in a higher serum level.
Diazepam Diazepam Trimethoprim may decrease the excretion rate of Diazepam which could result in a higher serum level.
Oxazepam Oxazepam Trimethoprim may decrease the excretion rate of Oxazepam which could result in a higher serum level.
Flurazepam Flurazepam Trimethoprim may decrease the excretion rate of Flurazepam which could result in a higher serum level.
Clorazepate Clorazepate Trimethoprim may decrease the excretion rate of Clorazepic acid which could result in a higher serum level.
Lorazepam Lorazepam Lorazepam may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Carmustine Carmustine Carmustine may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Amantadine Amantadine The serum concentration of Amantadine can be increased when it is combined with Trimethoprim.
Codeine Codeine Codeine may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Tranylcypromine Tranylcypromine The metabolism of Trimethoprim can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine Trimethoprim may decrease the excretion rate of Phenelzine which could result in a higher serum level.
Procarbazine Procarbazine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Procarbazine.
Tetracycline Tetracycline Trimethoprim may decrease the excretion rate of Tetracycline which could result in a higher serum level.
Minocycline Minocycline The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Minocycline.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Dapsone Dapsone The serum concentration of Dapsone can be increased when it is combined with Trimethoprim.
Methadone Methadone The metabolism of Trimethoprim can be decreased when combined with Methadone.
Benztropine Benztropine Benzatropine may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Maprotiline Maprotiline Trimethoprim may decrease the excretion rate of Maprotiline which could result in a higher serum level.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Trimethoprim.
Azathioprine Azathioprine Trimethoprim may increase the myelosuppressive activities of Azathioprine.
Methylphenidate Methylphenidate Methylphenidate may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Cytarabine Cytarabine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Cytarabine.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Carbamazepine Carbamazepine Trimethoprim may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
Methyldopa Methyldopa The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Methyldopa.
Prazosin Prazosin The serum concentration of Prazosin can be increased when it is combined with Trimethoprim.
Hydralazine Hydralazine Trimethoprim may decrease the excretion rate of Hydralazine which could result in a higher serum level.
Cimetidine Cimetidine The serum concentration of Cimetidine can be increased when it is combined with Trimethoprim.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Warfarin Warfarin The metabolism of Trimethoprim can be decreased when combined with Warfarin.
Clonazepam Clonazepam Trimethoprim may decrease the excretion rate of Clonazepam which could result in a higher serum level.
Loperamide Loperamide The metabolism of Loperamide can be decreased when combined with Trimethoprim.
Promethazine Promethazine The metabolism of Trimethoprim can be decreased when combined with Promethazine.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Nitrofurantoin.
Digoxin Digoxin The serum concentration of Digoxin can be increased when it is combined with Trimethoprim.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Trimethoprim.
Quinine Quinine The metabolism of Quinine can be decreased when combined with Trimethoprim.
Ethosuximide Ethosuximide The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Ethosuximide.
Triamterene Triamterene Triamterene may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Sulfinpyrazone Sulfinpyrazone The metabolism of Trimethoprim can be decreased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide Chlorothiazide may increase the excretion rate of Trimethoprim which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone Chlorthalidone Chlorthalidone may increase the excretion rate of Trimethoprim which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone Metolazone Trimethoprim may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide Isosorbide may increase the excretion rate of Trimethoprim which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital Secobarbital Secobarbital may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Desipramine Desipramine Trimethoprim may decrease the excretion rate of Desipramine which could result in a higher serum level.
Amitriptyline Amitriptyline The metabolism of Trimethoprim can be decreased when combined with Amitriptyline.
Imipramine Imipramine Trimethoprim may decrease the excretion rate of Imipramine which could result in a higher serum level.
Probenecid Probenecid The metabolism of Probenecid can be decreased when combined with Trimethoprim.
Quinidine Quinidine Quinidine may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Procainamide Procainamide The serum concentration of Procainamide can be increased when it is combined with Trimethoprim.
Isoniazid Isoniazid The metabolism of Trimethoprim can be decreased when combined with Isoniazid.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Disopyramide Disopyramide Disopyramide may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Valproic Acid Valproic Acid The metabolism of Trimethoprim can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Trimethoprim can be decreased when combined with Tamoxifen.
Butabarbital Butabarbital Butabarbital may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Methimazole Methimazole The metabolism of Trimethoprim can be decreased when combined with Methimazole.
Propylthiouracil Propylthiouracil The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Propylthiouracil.
Chlorpropamide Chlorpropamide Trimethoprim may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Trimethoprim.
Tolazamide Tolazamide Trimethoprim may decrease the excretion rate of Tolazamide which could result in a higher serum level.
Dextromethorphan Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Trimethoprim.
Niacin Niacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Niacin.
Baclofen Baclofen The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Baclofen is combined with Trimethoprim.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Methyclothiazide Methyclothiazide Methyclothiazide may increase the excretion rate of Trimethoprim which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Dantrolene Dantrolene The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone Chlorzoxazone may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Folic Acid Folic Acid The therapeutic efficacy of Trimethoprim can be decreased when used in combination with Folic acid.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Trimethoprim may decrease the excretion rate of Propranolol which could result in a higher serum level.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Trimethoprim which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Mercaptopurine Mercaptopurine Trimethoprim may increase the myelosuppressive activities of Mercaptopurine.
Phytonadione Phytonadione Trimethoprim may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Nadolol Nadolol Trimethoprim may decrease the excretion rate of Nadolol which could result in a higher serum level.
Allopurinol Allopurinol Allopurinol may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Flavoxate Flavoxate Trimethoprim may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Fluorouracil Injection Fluorouracil Injection The metabolism of Trimethoprim can be decreased when combined with Fluorouracil.
Colchicine Colchicine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Colchicine.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Dacarbazine Dacarbazine Trimethoprim may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Acetazolamide Acetazolamide The therapeutic efficacy of Trimethoprim can be increased when used in combination with Acetazolamide.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Ketoconazole Ketoconazole The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Ketoconazole.
Pyrantel Pyrantel Trimethoprim may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Vincristine Injection Vincristine Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Vincristine.
Captopril Captopril Trimethoprim may increase the hyperkalemic activities of Captopril.
Ethacrynic Acid Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Metoprolol Metoprolol Metoprolol may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Aspirin Aspirin Trimethoprim may decrease the excretion rate of Acetylsalicylic acid which could result in a higher serum level.
Salsalate Salsalate Salsalate may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Alprazolam Alprazolam Alprazolam may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Temazepam Temazepam Temazepam may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Triazolam Triazolam The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Triazolam.
Dicyclomine Dicyclomine Trimethoprim may decrease the excretion rate of Dicyclomine which could result in a higher serum level.
Propantheline Propantheline Trimethoprim may decrease the excretion rate of Propantheline which could result in a higher serum level.
Diltiazem Diltiazem The metabolism of Trimethoprim can be decreased when combined with Diltiazem.
Nifedipine Nifedipine Trimethoprim may decrease the excretion rate of Nifedipine which could result in a higher serum level.
Timolol Timolol Timolol may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Verapamil Verapamil The metabolism of Trimethoprim can be decreased when combined with Verapamil.
Atenolol Atenolol The risk or severity of hyperkalemia can be increased when Atenolol is combined with Trimethoprim.
Pindolol Pindolol The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Pindolol.
Cisplatin Injection Cisplatin Injection The serum concentration of Cisplatin can be increased when it is combined with Trimethoprim.
Diflunisal Diflunisal Diflunisal may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Piroxicam Piroxicam The metabolism of Piroxicam can be decreased when combined with Trimethoprim.
Bumetanide Bumetanide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Bumetanide.
Glyburide Glyburide The metabolism of Trimethoprim can be decreased when combined with Glyburide.
Glipizide Glipizide Trimethoprim may decrease the excretion rate of Glipizide which could result in a higher serum level.
Indapamide Indapamide Trimethoprim may increase the excretion rate of Indapamide which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin Amoxicillin Trimethoprim may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Trimethoprim may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline Pentoxifylline Trimethoprim may decrease the excretion rate of Pentoxifylline which could result in a higher serum level.
Pentamidine Injection Pentamidine Injection Pentamidine may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Labetalol Labetalol The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Labetalol.
Auranofin Auranofin Trimethoprim may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leuprolide is combined with Trimethoprim.
Gemfibrozil Gemfibrozil The metabolism of Trimethoprim can be decreased when combined with Gemfibrozil.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Enalapril Enalapril Trimethoprim may increase the hyperkalemic activities of Enalapril.
Flurbiprofen Flurbiprofen Flurbiprofen may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Amiodarone Amiodarone The metabolism of Trimethoprim can be decreased when combined with Amiodarone.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Buspirone Buspirone Trimethoprim may decrease the excretion rate of Buspirone which could result in a higher serum level.
Lovastatin Lovastatin The metabolism of Trimethoprim can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Ciprofloxacin.
Mesalamine Mesalamine Mesalazine may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Diclofenac Diclofenac The metabolism of Diclofenac can be decreased when combined with Trimethoprim.
Fluoxetine Fluoxetine The metabolism of Trimethoprim can be decreased when combined with Fluoxetine.
Nimodipine Nimodipine The risk or severity of hyperkalemia can be increased when Nimodipine is combined with Trimethoprim.
Clozapine Clozapine Clozapine may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Estazolam Estazolam Trimethoprim may decrease the excretion rate of Estazolam which could result in a higher serum level.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Trimethoprim.
Ofloxacin Ofloxacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Ofloxacin.
Didanosine Didanosine Trimethoprim may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Trimethoprim may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Benazepril Benazepril Trimethoprim may increase the hyperkalemic activities of Benazepril.
Etodolac Etodolac Etodolac may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Felodipine Felodipine The metabolism of Trimethoprim can be decreased when combined with Felodipine.
Fosinopril Fosinopril Trimethoprim may increase the hyperkalemic activities of Fosinopril.
Nabumetone Nabumetone Nabumetone may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Pravastatin Pravastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Trimethoprim.
Quinapril Quinapril Trimethoprim may increase the hyperkalemic activities of Quinapril.
Ramipril Ramipril Trimethoprim may increase the hyperkalemic activities of Ramipril.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Trimethoprim.
Amlodipine Amlodipine The risk or severity of hyperkalemia can be increased when Amlodipine is combined with Trimethoprim.
Teniposide Injection Teniposide Injection The metabolism of Trimethoprim can be decreased when combined with Teniposide.
Itraconazole Itraconazole The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Itraconazole.
Lisinopril Lisinopril Trimethoprim may increase the hyperkalemic activities of Lisinopril.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Atovaquone Atovaquone The metabolism of Trimethoprim can be decreased when combined with Atovaquone.
Sotalol Sotalol The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Sotalol.
Bisoprolol Bisoprolol The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Bisoprolol.
Zolpidem Zolpidem The metabolism of Trimethoprim can be decreased when combined with Zolpidem.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Trimethoprim.
Isradipine Isradipine The risk or severity of hyperkalemia can be increased when Isradipine is combined with Trimethoprim.
Omeprazole Omeprazole The metabolism of Trimethoprim can be decreased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Trimethoprim can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Trimethoprim can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine Venlafaxine may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Nizatidine Nizatidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Nizatidine.
Stavudine Stavudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Stavudine.
Fluvoxamine Fluvoxamine The metabolism of Trimethoprim can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone Trimethoprim may decrease the excretion rate of Nefazodone which could result in a higher serum level.
Lamotrigine Lamotrigine Trimethoprim may decrease the excretion rate of Lamotrigine which could result in a higher serum level.
Losartan Losartan The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Losartan.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Tramadol Tramadol Tramadol may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Moexipril Moexipril Trimethoprim may increase the hyperkalemic activities of Moexipril.
Lansoprazole Lansoprazole The metabolism of Trimethoprim can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Trimethoprim.
Nicardipine Nicardipine The metabolism of Trimethoprim can be decreased when combined with Nicardipine.
Bupropion Bupropion Trimethoprim may decrease the excretion rate of Bupropion which could result in a higher serum level.
Ticlopidine Ticlopidine Ticlopidine may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Saquinavir Saquinavir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Saquinavir.
Metformin Metformin The serum concentration of Metformin can be increased when it is combined with Trimethoprim.
Dalteparin Injection Dalteparin Injection The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Dalteparin.
Nisoldipine Nisoldipine The risk or severity of hyperkalemia can be increased when Nisoldipine is combined with Trimethoprim.
Lamivudine Lamivudine The serum concentration of Lamivudine can be increased when it is combined with Trimethoprim.
Acarbose Acarbose Acarbose may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Glimepiride Glimepiride The metabolism of Trimethoprim can be decreased when combined with Glimepiride.
Anastrozole Anastrozole The metabolism of Anastrozole can be decreased when combined with Trimethoprim.
Gemcitabine Injection Gemcitabine Injection Trimethoprim may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Indinavir Indinavir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Indinavir is combined with Trimethoprim.
Ritonavir Ritonavir The serum concentration of Trimethoprim can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Docetaxel.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Meropenem Injection Meropenem Injection Trimethoprim may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine Clomipramine Trimethoprim may decrease the excretion rate of Clomipramine which could result in a higher serum level.
Zafirlukast Zafirlukast The metabolism of Trimethoprim can be decreased when combined with Zafirlukast.
Fosfomycin Fosfomycin Trimethoprim may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Trandolapril Trandolapril Trimethoprim may increase the hyperkalemic activities of Trandolapril.
Topiramate Topiramate Topiramate may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Trimethoprim.
Valsartan Valsartan The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Valsartan.
Pramipexole Pramipexole The serum concentration of Pramipexole can be increased when it is combined with Trimethoprim.
Donepezil Donepezil The metabolism of Donepezil can be decreased when combined with Trimethoprim.
Nelfinavir Nelfinavir The metabolism of Trimethoprim can be decreased when combined with Nelfinavir.
Carvedilol Carvedilol The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Carvedilol.
Nilutamide Nilutamide The metabolism of Trimethoprim can be decreased when combined with Nilutamide.
Flutamide Flutamide Trimethoprim may decrease the excretion rate of Flutamide which could result in a higher serum level.
Selegiline Selegiline The metabolism of Selegiline can be decreased when combined with Trimethoprim.
Bicalutamide Bicalutamide The metabolism of Trimethoprim can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Trimethoprim can be decreased when combined with Sertraline.
Propafenone Propafenone The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Propafenone.
Letrozole Letrozole The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Trimethoprim is combined with Letrozole.
Irbesartan Irbesartan The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Irbesartan.
Tamsulosin Tamsulosin Trimethoprim may decrease the excretion rate of Tamsulosin which could result in a higher serum level.
Quetiapine Quetiapine Trimethoprim may decrease the excretion rate of Quetiapine which could result in a higher serum level.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Cetirizine Cetirizine Cetirizine may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Paroxetine Paroxetine The metabolism of Trimethoprim can be decreased when combined with Paroxetine.
Tolcapone Tolcapone The metabolism of Trimethoprim can be decreased when combined with Tolcapone.
Capecitabine Capecitabine The metabolism of Trimethoprim can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Trimethoprim can be decreased when combined with Efavirenz.
Abacavir Abacavir Trimethoprim may decrease the excretion rate of Abacavir which could result in a higher serum level.
Sildenafil Sildenafil The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Sildenafil is combined with Trimethoprim.
Pioglitazone Pioglitazone The metabolism of Pioglitazone can be decreased when combined with Trimethoprim.
Celecoxib Celecoxib The metabolism of Celecoxib can be decreased when combined with Trimethoprim.
Rosiglitazone Rosiglitazone The metabolism of Trimethoprim can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine Trimethoprim may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Thalidomide Thalidomide The metabolism of Thalidomide can be decreased when combined with Trimethoprim.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Nateglinide Nateglinide Trimethoprim may decrease the excretion rate of Nateglinide which could result in a higher serum level.
Rabeprazole Rabeprazole The metabolism of Trimethoprim can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Terbinafine can be decreased when combined with Trimethoprim.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

Still Confused? Ask the pharmacist a question here!