Tucatinib

Generic name: Pronounced as (too ka' ti nib)
Brand names
  • Tukysa®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 05/15/2020

Tucatinib is used with trastuzumab (Herceptin) and capecitabine (Xeloda) to treat a certain type of hormone receptor–positive breast cancer that has spread to other parts of the body and cannot be treated with surgery in adults who have already been treated with at least one other chemotherapy medication. Tucatinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells.

Tucatinib comes as a tablet to take by mouth. It is usually taken with or without food twice daily, about 12 hours apart. Take tucatinib at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tucatinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them. Do not take tablets that are broken, cracked, or damaged in any way.

If you vomit after taking tucatinib, do not take another dose. Continue your regular dosing schedule.

Your doctor may decrease your dose or temporarily or permanently stop your treatment if you experience certain side effects. This depends on how well the medication works for you and the side effects you experience. Be sure to tell your doctor how you are feeling during your treatment with tucatinib.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking tucatinib,

  • tell your doctor and pharmacist if you are allergic to tucatinib, any other medications, or any of the ingredients in tucatinib tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: digoxin (Lanoxin), gemfibrozil (Lopid), itraconazole (Onmel, Sporanox), metformin (Fortamet, Glucophage, Glumetza, Riomet), midazolam, repaglinide (Prandin), and rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with tucatinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you have or have ever had liver or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or if you plan on fathering a child. If you are female, you will need to take a pregnancy test before you start treatment and use birth control to prevent pregnancy during your treatment and for at least 1 week after your final dose. If you are a male, you and your partner should use birth control during your treatment and for 1 week after your final dose. Talk to your doctor about birth control methods that you can use during your treatment. If you or your partner become pregnant while taking tucatinib, call your doctor immediately. Tucatinib may harm the fetus.

  • tell your doctor if you are breastfeeding. You should not breastfeed while you are taking tucatinib and for 1 week after your final dose.

  • you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of taking tucatinib.

Unless your doctor tells you otherwise, continue your normal diet.

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Tucatinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • abdominal pain

    • loss of appetite

    • weight loss

    • fatigue

    • rash

    • headache

    • mouth ulcers

    • nose bleeding

    • numbness, burning, or tingling in the hands or feet

    • joint pain

    • redness or blisters on hands or feet

    • pale skin, fatigue, or shortness of breath

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

    • diarrhea

    • pain or discomfort in right upper stomach area; loss of appetite; bleeding or bruising more easily than normal; yellowing of skin and eyes; fatigue; or dark urine

    • seizure

  • Tucatinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture not in the bathroom. Do not remove the desiccant (drying agent) from the bottle. Properly dispose of any unused tablets 3 months after opening the bottle.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before and during your treatment to check your body's response to tucatinib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The metabolism of Tucatinib can be decreased when combined with Repaglinide.
Montelukast Montelukast The metabolism of Tucatinib can be decreased when combined with Montelukast.
Delavirdine Delavirdine The metabolism of Tucatinib can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Tucatinib can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Tucatinib can be decreased when combined with Atorvastatin.
Dolasetron Dolasetron The metabolism of Tucatinib can be decreased when combined with Dolasetron.
Aminophylline Aminophylline The metabolism of Tucatinib can be decreased when combined with Aminophylline.
Candesartan Candesartan The metabolism of Tucatinib can be decreased when combined with Candesartan.
Cilostazol Cilostazol The metabolism of Tucatinib can be decreased when combined with Cilostazol.
Clopidogrel Clopidogrel The metabolism of Tucatinib can be decreased when combined with Clopidogrel.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Tucatinib can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The metabolism of Tucatinib can be decreased when combined with Conjugated estrogens.
Fenofibrate Fenofibrate The metabolism of Tucatinib can be decreased when combined with Fenofibrate.
Guanfacine Guanfacine The metabolism of Tucatinib can be decreased when combined with Guanfacine.
Methylergonovine Methylergonovine The metabolism of Tucatinib can be decreased when combined with Methylergometrine.
Paregoric Paregoric Morphine may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Prednisone Prednisone The metabolism of Tucatinib can be decreased when combined with Prednisone.
Ranitidine Ranitidine The serum concentration of Ranitidine can be increased when it is combined with Tucatinib.
Reserpine Reserpine The serum concentration of Tucatinib can be increased when it is combined with Reserpine.
Tacrolimus Tacrolimus The metabolism of Tucatinib can be decreased when combined with Tacrolimus.
Triamcinolone Triamcinolone The metabolism of Tucatinib can be decreased when combined with Triamcinolone.
Doxycycline Injection Doxycycline Injection The metabolism of Tucatinib can be decreased when combined with Doxycycline.
Fluconazole Injection Fluconazole Injection The serum concentration of Tucatinib can be increased when it is combined with Fluconazole.
Levofloxacin Injection Levofloxacin Injection The excretion of Levofloxacin can be decreased when combined with Tucatinib.
Meperidine Injection Meperidine Injection The metabolism of Tucatinib can be decreased when combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Tucatinib can be decreased when combined with Methylprednisolone.
Metoclopramide Injection Metoclopramide Injection The metabolism of Tucatinib can be decreased when combined with Metoclopramide.
Metronidazole Injection Metronidazole Injection The metabolism of Tucatinib can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection Morphine may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The metabolism of Tucatinib can be decreased when combined with Zidovudine.
Cyclosporine Cyclosporine Cyclosporine may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Ondansetron Ondansetron The metabolism of Tucatinib can be decreased when combined with Ondansetron.
Granisetron Granisetron The metabolism of Tucatinib can be decreased when combined with Granisetron.
Torsemide Torsemide The metabolism of Tucatinib can be decreased when combined with Torasemide.
Alosetron Alosetron The metabolism of Tucatinib can be decreased when combined with Alosetron.
Dofetilide Dofetilide The metabolism of Dofetilide can be decreased when combined with Tucatinib.
Hydroxychloroquine Hydroxychloroquine The metabolism of Tucatinib can be decreased when combined with Hydroxychloroquine.
Meloxicam Meloxicam The metabolism of Tucatinib can be decreased when combined with Meloxicam.
Pantoprazole Pantoprazole The metabolism of Tucatinib can be decreased when combined with Pantoprazole.
Telmisartan Telmisartan Telmisartan may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Zaleplon Zaleplon The metabolism of Tucatinib can be decreased when combined with Zaleplon.
Anakinra Anakinra The metabolism of Tucatinib can be increased when combined with Anakinra.
Trimipramine Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Tucatinib.
Etanercept Injection Etanercept Injection The metabolism of Tucatinib can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Tucatinib can be decreased when combined with Modafinil.
Tenofovir Tenofovir Tucatinib may decrease the excretion rate of Tenofovir which could result in a higher serum level.
Sirolimus Sirolimus Tucatinib may decrease the excretion rate of Sirolimus which could result in a higher serum level.
Epinephrine Injection Epinephrine Injection The serum concentration of Epinephrine can be increased when it is combined with Tucatinib.
Eplerenone Eplerenone The metabolism of Tucatinib can be decreased when combined with Eplerenone.
Escitalopram Escitalopram The metabolism of Tucatinib can be decreased when combined with Escitalopram.
Zonisamide Zonisamide The metabolism of Tucatinib can be decreased when combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Tucatinib can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Tucatinib can be decreased when combined with Aripiprazole.
Teriparatide Injection Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Tucatinib.
Atazanavir Atazanavir The metabolism of Tucatinib can be decreased when combined with Atazanavir.
Almotriptan Almotriptan The metabolism of Tucatinib can be decreased when combined with Almotriptan.
Eletriptan Eletriptan The metabolism of Tucatinib can be decreased when combined with Eletriptan.
Mefloquine Mefloquine The metabolism of Tucatinib can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Tucatinib can be decreased when combined with Rosuvastatin.
Vardenafil Vardenafil Vardenafil may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Alfuzosin Alfuzosin The metabolism of Tucatinib can be decreased when combined with Alfuzosin.
Aprepitant Aprepitant The metabolism of Tucatinib can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine The excretion of Emtricitabine can be decreased when combined with Tucatinib.
Memantine Memantine The serum concentration of Memantine can be increased when it is combined with Tucatinib.
Tegaserod Tegaserod Tegaserod may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Tadalafil Tadalafil The metabolism of Tucatinib can be decreased when combined with Tadalafil.
Fosamprenavir Fosamprenavir The metabolism of Tucatinib can be decreased when combined with Fosamprenavir.
Progesterone Progesterone The metabolism of Tucatinib can be decreased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The metabolism of Tucatinib can be decreased when combined with Apomorphine.
Infliximab Injection Infliximab Injection The metabolism of Tucatinib can be increased when combined with Infliximab.
Rifaximin Rifaximin The metabolism of Tucatinib can be increased when combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Tucatinib can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Tucatinib can be decreased when combined with Norethisterone.
Tinidazole Tinidazole The metabolism of Tucatinib can be decreased when combined with Tinidazole.
Bosentan Bosentan The metabolism of Tucatinib can be decreased when combined with Bosentan.
Cinacalcet Cinacalcet The metabolism of Tucatinib can be decreased when combined with Cinacalcet.
Erlotinib Erlotinib The metabolism of Tucatinib can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The metabolism of Tucatinib can be decreased when combined with Eszopiclone.
Ganciclovir Ganciclovir The excretion of Ganciclovir can be decreased when combined with Tucatinib.
Solifenacin Solifenacin The metabolism of Tucatinib can be decreased when combined with Solifenacin.
Voriconazole Voriconazole The metabolism of Tucatinib can be decreased when combined with Voriconazole.
Ramelteon Ramelteon The metabolism of Tucatinib can be decreased when combined with Ramelteon.
Darifenacin Darifenacin The metabolism of Tucatinib can be decreased when combined with Darifenacin.
Fentanyl Fentanyl The metabolism of Tucatinib can be decreased when combined with Fentanyl.
Deferasirox Deferasirox The metabolism of Tucatinib can be decreased when combined with Deferasirox.
Tipranavir Tipranavir Tipranavir may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Felbamate Felbamate The metabolism of Tucatinib can be decreased when combined with Felbamate.
Ranolazine Ranolazine The serum concentration of Tucatinib can be increased when it is combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Tucatinib can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Tucatinib can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin Sitagliptin may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Varenicline Varenicline The excretion of Varenicline can be decreased when combined with Tucatinib.
Gefitinib Gefitinib The metabolism of Tucatinib can be decreased when combined with Gefitinib.
Paliperidone Paliperidone Paliperidone may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Exemestane Exemestane The metabolism of Tucatinib can be decreased when combined with Exemestane.
Bortezomib Bortezomib The metabolism of Tucatinib can be decreased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection The serum concentration of Clofarabine can be increased when it is combined with Tucatinib.
Oxaliplatin Injection Oxaliplatin Injection The serum concentration of Oxaliplatin can be increased when it is combined with Tucatinib.
Posaconazole Posaconazole Posaconazole may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Primaquine Primaquine The metabolism of Tucatinib can be decreased when combined with Primaquine.
Aliskiren Aliskiren The metabolism of Tucatinib can be decreased when combined with Aliskiren.
Darunavir Darunavir The metabolism of Tucatinib can be decreased when combined with Darunavir.
Nabilone Nabilone The metabolism of Tucatinib can be decreased when combined with Nabilone.
Retapamulin Retapamulin The metabolism of Tucatinib can be decreased when combined with Retapamulin.
Sorafenib Sorafenib The metabolism of Tucatinib can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Tucatinib can be decreased when combined with Sunitinib.
Dronabinol Dronabinol The metabolism of Tucatinib can be decreased when combined with Dronabinol.
Lapatinib Lapatinib The metabolism of Tucatinib can be decreased when combined with Lapatinib.
Levocetirizine Levocetirizine The metabolism of Tucatinib can be decreased when combined with Levocetirizine.
Dasatinib Dasatinib Dasatinib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Mexiletine Mexiletine The metabolism of Tucatinib can be decreased when combined with Mexiletine.
Ivermectin Ivermectin The metabolism of Tucatinib can be decreased when combined with Ivermectin.
Temsirolimus Temsirolimus Temsirolimus may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Maraviroc Maraviroc The metabolism of Tucatinib can be decreased when combined with Maraviroc.
Nilotinib Nilotinib The metabolism of Tucatinib can be decreased when combined with Nilotinib.
Toremifene Toremifene Toremifene may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Bexarotene Bexarotene The metabolism of Tucatinib can be decreased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Tucatinib can be decreased when combined with Budesonide.
Etravirine Etravirine The metabolism of Tucatinib can be decreased when combined with Etravirine.
Desvenlafaxine Desvenlafaxine The metabolism of Tucatinib can be decreased when combined with Desvenlafaxine.
Cevimeline Cevimeline The metabolism of Tucatinib can be decreased when combined with Cevimeline.
Nebivolol Nebivolol The metabolism of Tucatinib can be decreased when combined with Nebivolol.
Tretinoin Tretinoin The metabolism of Tucatinib can be decreased when combined with Tretinoin.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Tucatinib.
Flecainide Flecainide The excretion of Flecainide can be decreased when combined with Tucatinib.
Certolizumab Injection Certolizumab Injection The metabolism of Tucatinib can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Tucatinib can be decreased when combined with Ixabepilone.
Irinotecan Injection Irinotecan Injection The metabolism of Tucatinib can be decreased when combined with Irinotecan.
Estramustine Estramustine The metabolism of Tucatinib can be decreased when combined with Estramustine.
Praziquantel Praziquantel The metabolism of Tucatinib can be decreased when combined with Praziquantel.
Mitotane Mitotane The metabolism of Tucatinib can be increased when combined with Mitotane.
Rufinamide Rufinamide The metabolism of Tucatinib can be decreased when combined with Rufinamide.
Silodosin Silodosin Silodosin may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Midazolam Midazolam The metabolism of Tucatinib can be decreased when combined with Midazolam.
Eltrombopag Eltrombopag Eltrombopag may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Milnacipran Milnacipran The metabolism of Tucatinib can be decreased when combined with Milnacipran.
Dexlansoprazole Dexlansoprazole The metabolism of Tucatinib can be decreased when combined with Dexlansoprazole.
Fesoterodine Fesoterodine The metabolism of Tucatinib can be decreased when combined with Fesoterodine.
Iloperidone Iloperidone The metabolism of Tucatinib can be decreased when combined with Iloperidone.
Prasugrel Prasugrel The metabolism of Tucatinib can be decreased when combined with Prasugrel.
Lacosamide Lacosamide The metabolism of Tucatinib can be decreased when combined with Lacosamide.
Everolimus Everolimus Everolimus may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Tolvaptan may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Dronedarone Dronedarone The metabolism of Tucatinib can be decreased when combined with Dronedarone.
Palonosetron Injection Palonosetron Injection The metabolism of Tucatinib can be decreased when combined with Palonosetron.
Saxagliptin Saxagliptin The metabolism of Tucatinib can be decreased when combined with Saxagliptin.
Romidepsin Injection Romidepsin Injection Romidepsin may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Topotecan Topotecan The excretion of Topotecan can be decreased when combined with Tucatinib.
Golimumab Injection Golimumab Injection The metabolism of Tucatinib can be increased when combined with Golimumab.
Pazopanib Pazopanib Pazopanib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Asenapine Asenapine The metabolism of Tucatinib can be decreased when combined with Asenapine.
Pitavastatin Pitavastatin The metabolism of Tucatinib can be decreased when combined with Pitavastatin.
Albendazole Albendazole The metabolism of Tucatinib can be decreased when combined with Albendazole.
Ulipristal Ulipristal The metabolism of Tucatinib can be decreased when combined with Ulipristal.
Levonorgestrel Levonorgestrel The metabolism of Tucatinib can be decreased when combined with Levonorgestrel.
Oxymorphone Oxymorphone The metabolism of Tucatinib can be decreased when combined with Oxymorphone.
Tocilizumab Injection Tocilizumab Injection The metabolism of Tucatinib can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine The serum concentration of Dalfampridine can be increased when it is combined with Tucatinib.
Cabazitaxel Injection Cabazitaxel Injection Cabazitaxel may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Lurasidone Lurasidone The metabolism of Tucatinib can be decreased when combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection The metabolism of Tucatinib can be decreased when combined with Acetaminophen.
Vilazodone Vilazodone The metabolism of Tucatinib can be decreased when combined with Vilazodone.
Busulfan Injection Busulfan Injection The metabolism of Tucatinib can be decreased when combined with Busulfan.
Roflumilast Roflumilast The metabolism of Tucatinib can be decreased when combined with Roflumilast.
Linagliptin Linagliptin Tucatinib may decrease the excretion rate of Linagliptin which could result in a higher serum level.
Rilpivirine Rilpivirine The metabolism of Tucatinib can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir Glecaprevir may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Potassium Iodide Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Tucatinib.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Tucatinib can be decreased when combined with Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Tucatinib can be decreased when combined with Abiraterone.
Rivaroxaban Rivaroxaban Rivaroxaban may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Ticagrelor Ticagrelor Ticagrelor may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Tucatinib can be decreased when combined with Brentuximab vedotin.
Ruxolitinib Ruxolitinib The metabolism of Tucatinib can be decreased when combined with Ruxolitinib.
Vandetanib Vandetanib The metabolism of Tucatinib can be decreased when combined with Vandetanib.
Clobazam Clobazam Clobazam may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Vemurafenib Vemurafenib The serum concentration of Tucatinib can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Tucatinib can be decreased when combined with Vismodegib.
Ivacaftor Ivacaftor The metabolism of Tucatinib can be decreased when combined with Ivacaftor.
Axitinib Axitinib The metabolism of Tucatinib can be decreased when combined with Axitinib.
Crizotinib Crizotinib Crizotinib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Cabergoline Cabergoline The metabolism of Tucatinib can be decreased when combined with Cabergoline.
Ambrisentan Ambrisentan Ambrisentan may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Ezogabine Ezogabine The metabolism of Tucatinib can be decreased when combined with Tiagabine.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Tucatinib can be increased when it is combined with Carfilzomib.
Enzalutamide Enzalutamide The metabolism of Tucatinib can be increased when combined with Enzalutamide.
Mirabegron Mirabegron Mirabegron may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Regorafenib Regorafenib The metabolism of Tucatinib can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Tucatinib can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Tucatinib can be decreased when combined with Corticotropin.
Teriflunomide Teriflunomide Teriflunomide may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Tucatinib can be decreased when combined with Cabozantinib.
Bedaquiline Bedaquiline The metabolism of Tucatinib can be decreased when combined with Bedaquiline.
Tofacitinib Tofacitinib The metabolism of Tucatinib can be decreased when combined with Tofacitinib.
Alogliptin Alogliptin The metabolism of Tucatinib can be decreased when combined with Alogliptin.
Ponatinib Ponatinib The metabolism of Tucatinib can be decreased when combined with Ponatinib.
Pomalidomide Pomalidomide Pomalidomide may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection Trastuzumab emtansine may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Apixaban Apixaban Apixaban may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Canagliflozin Canagliflozin Canagliflozin may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Dabrafenib Dabrafenib The metabolism of Tucatinib can be decreased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Tucatinib can be decreased when combined with Ospemifene.
Trametinib Trametinib The metabolism of Tucatinib can be decreased when combined with Trametinib.
Dolutegravir Dolutegravir Dolutegravir may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Afatinib Afatinib Afatinib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran The metabolism of Tucatinib can be decreased when combined with Levomilnacipran.
Vortioxetine Vortioxetine The metabolism of Tucatinib can be decreased when combined with Vortioxetine.
Perampanel Perampanel The metabolism of Tucatinib can be decreased when combined with Perampanel.
Ibrutinib Ibrutinib The metabolism of Tucatinib can be decreased when combined with Ibrutinib.
Lomitapide Lomitapide The metabolism of Tucatinib can be decreased when combined with Lomitapide.
Avanafil Avanafil The metabolism of Tucatinib can be decreased when combined with Avanafil.
Ketorolac Injection Ketorolac Injection The metabolism of Tucatinib can be decreased when combined with Ketorolac.
Simeprevir Simeprevir Simeprevir may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Sofosbuvir Sofosbuvir Sofosbuvir may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Dapagliflozin Dapagliflozin The metabolism of Tucatinib can be decreased when combined with Dapagliflozin.
Apremilast Apremilast The metabolism of Tucatinib can be decreased when combined with Apremilast.
Ceritinib Ceritinib Ceritinib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Siltuximab Injection Siltuximab Injection The metabolism of Tucatinib can be increased when combined with Siltuximab.
Belinostat Injection Belinostat Injection Belinostat may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Idelalisib Idelalisib Idelalisib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Testosterone Injection Testosterone Injection The metabolism of Tucatinib can be decreased when combined with Testosterone.
Vorapaxar Vorapaxar The metabolism of Tucatinib can be decreased when combined with Vorapaxar.
Hydrocodone Hydrocodone The metabolism of Tucatinib can be decreased when combined with Hydrocodone.
Suvorexant Suvorexant The metabolism of Tucatinib can be decreased when combined with Suvorexant.
Edoxaban Edoxaban Edoxaban may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Olaparib Olaparib The metabolism of Tucatinib can be decreased when combined with Olaparib.
Tasimelteon Tasimelteon The metabolism of Tucatinib can be decreased when combined with Tasimelteon.
Riociguat Riociguat The metabolism of Tucatinib can be decreased when combined with Riociguat.
Nintedanib Nintedanib Nintedanib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Secukinumab Injection Secukinumab Injection The metabolism of Tucatinib can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The metabolism of Tucatinib can be decreased when combined with Risperidone.
Palbociclib Palbociclib The metabolism of Tucatinib can be decreased when combined with Palbociclib.
Lenvatinib Lenvatinib Lenvatinib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Naloxegol Naloxegol The metabolism of Tucatinib can be decreased when combined with Naloxegol.
Panobinostat Panobinostat Panobinostat may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Haloperidol Injection Haloperidol Injection The metabolism of Tucatinib can be decreased when combined with Haloperidol.
Ivabradine Ivabradine The metabolism of Tucatinib can be decreased when combined with Ivabradine.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Tucatinib can be decreased when combined with Isavuconazonium.
Macitentan Macitentan The metabolism of Tucatinib can be decreased when combined with Macitentan.
Sonidegib Sonidegib The metabolism of Tucatinib can be decreased when combined with Sonidegib.
Flibanserin Flibanserin The metabolism of Tucatinib can be decreased when combined with Flibanserin.
Rolapitant Rolapitant The metabolism of Tucatinib can be decreased when combined with Rolapitant.
Prednisolone Prednisolone The metabolism of Tucatinib can be decreased when combined with Prednisolone.
Daclatasvir Daclatasvir The metabolism of Tucatinib can be decreased when combined with Daclatasvir.
Brexpiprazole Brexpiprazole The metabolism of Tucatinib can be decreased when combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The metabolism of Tucatinib can be decreased when combined with Ziprasidone.
Cariprazine Cariprazine The metabolism of Tucatinib can be decreased when combined with Cariprazine.
Cobimetinib Cobimetinib Cobimetinib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Trabectedin Injection Trabectedin Injection The metabolism of Tucatinib can be decreased when combined with Trabectedin.
Osimertinib Osimertinib Osimertinib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Alectinib Alectinib Alectinib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Ixazomib Ixazomib The metabolism of Tucatinib can be decreased when combined with Ixazomib.
Rifapentine Rifapentine The metabolism of Tucatinib can be increased when combined with Rifapentine.
Dexamethasone Injection Dexamethasone Injection The metabolism of Tucatinib can be increased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The metabolism of Tucatinib can be decreased when combined with Brivaracetam.
Venetoclax Venetoclax Venetoclax may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Cobicistat Cobicistat The metabolism of Tucatinib can be decreased when combined with Cobicistat.
Selexipag Selexipag Selexipag may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Rucaparib Rucaparib Rucaparib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Ribociclib Ribociclib The metabolism of Tucatinib can be decreased when combined with Ribociclib.
Parathyroid Hormone Injection Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Tucatinib.
Brigatinib Brigatinib The metabolism of Tucatinib can be decreased when combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Tucatinib can be decreased when combined with Doxepin.
Deutetrabenazine Deutetrabenazine The metabolism of Tucatinib can be decreased when combined with Deutetrabenazine.
Valbenazine Valbenazine The metabolism of Tucatinib can be decreased when combined with Valbenazine.
Deflazacort Deflazacort The metabolism of Tucatinib can be decreased when combined with Deflazacort.
Safinamide Safinamide The metabolism of Tucatinib can be decreased when combined with Safinamide.
Midostaurin Midostaurin The metabolism of Tucatinib can be increased when combined with Midostaurin.
Neratinib Neratinib The metabolism of Tucatinib can be decreased when combined with Neratinib.
Abaloparatide Injection Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Tucatinib.
Enasidenib Enasidenib The metabolism of Tucatinib can be decreased when combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection Inotuzumab ozogamicin may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Tucatinib can be decreased when combined with Fosaprepitant.
Copanlisib Injection Copanlisib Injection Tucatinib may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Abemaciclib Abemaciclib The metabolism of Tucatinib can be decreased when combined with Abemaciclib.
Betrixaban Betrixaban Tucatinib may decrease the excretion rate of Betrixaban which could result in a higher serum level.
Acalabrutinib Acalabrutinib The metabolism of Tucatinib can be decreased when combined with Acalabrutinib.
Letermovir Letermovir Letermovir may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Ertugliflozin Ertugliflozin Tucatinib may decrease the excretion rate of Ertugliflozin which could result in a higher serum level.
Buprenorphine Injection Buprenorphine Injection The metabolism of Tucatinib can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The metabolism of Tucatinib can be increased when combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Tucatinib can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag Avatrombopag may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Baricitinib Baricitinib Baricitinib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Eliglustat Eliglustat Eliglustat may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Encorafenib Encorafenib The metabolism of Tucatinib can be decreased when combined with Encorafenib.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Tucatinib.
Ivosidenib Ivosidenib Ivosidenib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Lusutrombopag Lusutrombopag Tucatinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Elagolix Elagolix Elagolix may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Eravacycline Injection Eravacycline Injection The metabolism of Tucatinib can be decreased when combined with Eravacycline.
Doravirine Doravirine The metabolism of Tucatinib can be decreased when combined with Doravirine.
Cannabidiol Cannabidiol The metabolism of Tucatinib can be decreased when combined with Cannabidiol.
Dacomitinib Dacomitinib Dacomitinib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Duvelisib Duvelisib Tucatinib may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Omadacycline Omadacycline Tucatinib may decrease the excretion rate of Omadacycline which could result in a higher serum level.
Sarecycline Sarecycline The serum concentration of Tucatinib can be increased when it is combined with Sarecycline.
Talazoparib Talazoparib Tucatinib may decrease the excretion rate of Talazoparib which could result in a higher serum level.
Gilteritinib Gilteritinib Gilteritinib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Glasdegib Glasdegib Glasdegib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Tucatinib.
Larotrectinib Larotrectinib Tucatinib may decrease the excretion rate of Larotrectinib which could result in a higher serum level.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Tucatinib can be decreased when combined with Paclitaxel.
Rifamycin Rifamycin The metabolism of Tucatinib can be increased when combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Tucatinib can be decreased when combined with Prucalopride.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Tucatinib can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Tucatinib can be decreased when combined with Siponimod.
Acyclovir Ophthalmic Acyclovir Ophthalmic The excretion of Acyclovir can be decreased when combined with Tucatinib.
Erdafitinib Erdafitinib The serum concentration of Tucatinib can be increased when it is combined with Erdafitinib.
Esomeprazole Injection Esomeprazole Injection The metabolism of Tucatinib can be decreased when combined with Esomeprazole.
Alpelisib Alpelisib The metabolism of Tucatinib can be decreased when combined with Alpelisib.
Polatuzumab vedotin-piiq Injection Polatuzumab vedotin-piiq Injection The metabolism of Tucatinib can be decreased when combined with Polatuzumab vedotin.
Solriamfetol Solriamfetol The serum concentration of Solriamfetol can be increased when it is combined with Tucatinib.
Selinexor Selinexor The metabolism of Tucatinib can be decreased when combined with Selinexor.
Darolutamide Darolutamide The serum concentration of Tucatinib can be increased when it is combined with Darolutamide.
Triclabendazole Triclabendazole The metabolism of Tucatinib can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The metabolism of Tucatinib can be decreased when combined with Entrectinib.
Upadacitinib Upadacitinib The metabolism of Tucatinib can be decreased when combined with Upadacitinib.
Istradefylline Istradefylline The metabolism of Tucatinib can be decreased when combined with Istradefylline.
Pitolisant Pitolisant The metabolism of Tucatinib can be decreased when combined with Pitolisant.
Pretomanid Pretomanid The metabolism of Tucatinib can be decreased when combined with Pretomanid.
Fedratinib Fedratinib Fedratinib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Lefamulin Lefamulin Tucatinib may decrease the excretion rate of Lefamulin which could result in a higher serum level.
Phenytoin Injection Phenytoin Injection The metabolism of Tucatinib can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Tucatinib can be increased when combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection Tucatinib may decrease the excretion rate of Enfortumab vedotin which could result in a higher serum level.
Zanubrutinib Zanubrutinib The metabolism of Tucatinib can be decreased when combined with Zanubrutinib.
Voxelotor Voxelotor The metabolism of Tucatinib can be decreased when combined with Voxelotor.
Avapritinib Avapritinib The metabolism of Tucatinib can be decreased when combined with Avapritinib.
Lumateperone Lumateperone The metabolism of Tucatinib can be decreased when combined with Lumateperone.
Lasmiditan Lasmiditan The serum concentration of Tucatinib can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant Tucatinib may decrease the excretion rate of Ubrogepant which could result in a higher serum level.
Tazemetostat Tazemetostat Tucatinib may decrease the excretion rate of Tazemetostat which could result in a higher serum level.
Cenobamate Cenobamate The metabolism of Tucatinib can be decreased when combined with Cenobamate.
Pemigatinib Pemigatinib The metabolism of Tucatinib can be decreased when combined with Pemigatinib.
Ozanimod Ozanimod The metabolism of Ozanimod can be decreased when combined with Tucatinib.
Selumetinib Selumetinib Tucatinib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Rimegepant Rimegepant Tucatinib may decrease the excretion rate of Rimegepant which could result in a higher serum level.
Remdesivir Injection Remdesivir Injection Tucatinib may decrease the excretion rate of Remdesivir which could result in a higher serum level.
Ripretinib Ripretinib Ripretinib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Selpercatinib Selpercatinib The metabolism of Tucatinib can be decreased when combined with Selpercatinib.
Capmatinib Capmatinib The metabolism of Tucatinib can be decreased when combined with Capmatinib.
Lemborexant Lemborexant Tucatinib may decrease the excretion rate of Lemborexant which could result in a higher serum level.
Fostemsavir Fostemsavir Fostemsavir may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Lurbinectedin Injection Lurbinectedin Injection The metabolism of Tucatinib can be decreased when combined with Lurbinectedin.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection Tucatinib may decrease the excretion rate of Belantamab mafodotin which could result in a higher serum level.
Pralsetinib Pralsetinib Pralsetinib may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Opicapone Opicapone The metabolism of Tucatinib can be decreased when combined with Opicapone.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Tucatinib can be decreased when combined with Drospirenone.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Tucatinib can be decreased when combined with Vitamin E.
Theophylline Theophylline The metabolism of Tucatinib can be decreased when combined with Theophylline.
Mefenamic Acid Mefenamic Acid The metabolism of Tucatinib can be decreased when combined with Mefenamic acid.
Naproxen Naproxen The metabolism of Tucatinib can be decreased when combined with Naproxen.
Trazodone Trazodone The metabolism of Tucatinib can be decreased when combined with Trazodone.
Isotretinoin Isotretinoin The metabolism of Tucatinib can be decreased when combined with Isotretinoin.
Phenobarbital Phenobarbital The metabolism of Tucatinib can be increased when combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The metabolism of Tucatinib can be decreased when combined with Methotrexate.
Primidone Primidone The metabolism of Tucatinib can be increased when combined with Primidone.
Chlorpromazine Chlorpromazine The metabolism of Tucatinib can be decreased when combined with Chlorpromazine.
Diazepam Diazepam The metabolism of Tucatinib can be decreased when combined with Diazepam.
Flurazepam Flurazepam The metabolism of Tucatinib can be decreased when combined with Flurazepam.
Clorazepate Clorazepate The metabolism of Tucatinib can be decreased when combined with Clorazepic acid.
Lorazepam Lorazepam The metabolism of Tucatinib can be decreased when combined with Lorazepam.
Amantadine Amantadine The serum concentration of Amantadine can be increased when it is combined with Tucatinib.
Codeine Codeine The metabolism of Tucatinib can be decreased when combined with Codeine.
Bromocriptine Bromocriptine The metabolism of Tucatinib can be decreased when combined with Bromocriptine.
Phenelzine Phenelzine The metabolism of Tucatinib can be decreased when combined with Phenelzine.
Ergoloid Mesylates Ergoloid Mesylates The metabolism of Tucatinib can be decreased when combined with Ergoloid mesylate.
Tetracycline Tetracycline The metabolism of Tucatinib can be decreased when combined with Tetracycline.
Prochlorperazine Prochlorperazine The metabolism of Tucatinib can be decreased when combined with Prochlorperazine.
Dapsone Dapsone The metabolism of Tucatinib can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The metabolism of Tucatinib can be decreased when combined with Sulfadiazine.
Oxycodone Oxycodone The metabolism of Tucatinib can be decreased when combined with Oxycodone.
Methadone Methadone The metabolism of Tucatinib can be decreased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Tucatinib can be decreased when combined with Oxybutynin.
Ibuprofen Ibuprofen The metabolism of Tucatinib can be decreased when combined with Ibuprofen.
Orphenadrine Orphenadrine The metabolism of Tucatinib can be decreased when combined with Orphenadrine.
Phentermine Phentermine The metabolism of Tucatinib can be decreased when combined with Phentermine.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Hydrocortisone Hydrocortisone The metabolism of Tucatinib can be decreased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Tucatinib can be decreased when combined with Doxorubicin.
Dactinomycin Dactinomycin Dactinomycin may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Carbamazepine Carbamazepine The metabolism of Tucatinib can be increased when combined with Carbamazepine.
Clonidine Clonidine The metabolism of Tucatinib can be decreased when combined with Clonidine.
Prazosin Prazosin The serum concentration of Prazosin can be increased when it is combined with Tucatinib.
Cimetidine Cimetidine The serum concentration of Cimetidine can be increased when it is combined with Tucatinib.
Warfarin Warfarin The metabolism of Tucatinib can be decreased when combined with Warfarin.
Clonazepam Clonazepam The metabolism of Tucatinib can be decreased when combined with Clonazepam.
Loperamide Loperamide Loperamide may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Tucatinib can be increased when combined with Griseofulvin.
Digoxin Digoxin Tucatinib may decrease the excretion rate of Digoxin which could result in a higher serum level.
Loxapine Loxapine The serum concentration of Tucatinib can be increased when it is combined with Loxapine.
Chloroquine Chloroquine The metabolism of Tucatinib can be decreased when combined with Chloroquine.
Quinine Quinine Quinine may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Ethosuximide Ethosuximide The metabolism of Tucatinib can be decreased when combined with Ethosuximide.
Calcitriol Calcitriol The metabolism of Tucatinib can be decreased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Tucatinib can be decreased when combined with Sulfinpyrazone.
Clindamycin Injection Clindamycin Injection The metabolism of Tucatinib can be decreased when combined with Clindamycin.
Secobarbital Secobarbital The metabolism of Tucatinib can be increased when combined with Secobarbital.
Amitriptyline Amitriptyline The metabolism of Tucatinib can be decreased when combined with Amitriptyline.
Imipramine Imipramine The metabolism of Tucatinib can be decreased when combined with Imipramine.
Probenecid Probenecid The metabolism of Tucatinib can be increased when combined with Probenecid.
Quinidine Quinidine Quinidine may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Procainamide Procainamide The serum concentration of Procainamide can be increased when it is combined with Tucatinib.
Rifampin Rifampin The metabolism of Tucatinib can be increased when combined with Rifampicin.
Disopyramide Disopyramide The metabolism of Tucatinib can be decreased when combined with Disopyramide.
Valproic Acid Valproic Acid The metabolism of Tucatinib can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Tucatinib can be decreased when combined with Tamoxifen.
Levothyroxine Levothyroxine The therapeutic efficacy of Tucatinib can be decreased when used in combination with Levothyroxine.
Liothyronine Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Tucatinib.
Methimazole Methimazole The therapeutic efficacy of Methimazole can be decreased when used in combination with Tucatinib.
Propylthiouracil Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Tucatinib.
Tolbutamide Tolbutamide The metabolism of Tucatinib can be decreased when combined with Tolbutamide.
Dextromethorphan Dextromethorphan The metabolism of Tucatinib can be decreased when combined with Dextromethorphan.
Cyclobenzaprine Cyclobenzaprine The metabolism of Tucatinib can be decreased when combined with Cyclobenzaprine.
Chlorpheniramine Chlorpheniramine The metabolism of Tucatinib can be decreased when combined with Chlorpheniramine.
Chlorzoxazone Chlorzoxazone The metabolism of Tucatinib can be decreased when combined with Chlorzoxazone.
Disulfiram Disulfiram The metabolism of Tucatinib can be decreased when combined with Disulfiram.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Tucatinib can be decreased when combined with Propranolol.
Nortriptyline Nortriptyline The metabolism of Tucatinib can be decreased when combined with Nortriptyline.
Spironolactone Spironolactone The metabolism of Tucatinib can be decreased when combined with Spironolactone.
Nadolol Nadolol The excretion of Nadolol can be decreased when combined with Tucatinib.
Clomiphene Clomiphene Clomifene may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Fluorouracil Injection Fluorouracil Injection The metabolism of Tucatinib can be decreased when combined with Fluorouracil.
Colchicine Colchicine Colchicine may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Cephalexin Cephalexin The metabolism of Cephalexin can be decreased when combined with Tucatinib.
Calcitonin Salmon Injection Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Tucatinib.
Ketoconazole Ketoconazole The metabolism of Tucatinib can be decreased when combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The metabolism of Tucatinib can be decreased when combined with Thiotepa.
Vincristine Injection Vincristine Injection Tucatinib may decrease the excretion rate of Vincristine which could result in a higher serum level.
Vinblastine Vinblastine Vinblastine may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Metoprolol Metoprolol The metabolism of Tucatinib can be decreased when combined with Metoprolol.
Hydroxyzine Hydroxyzine The metabolism of Tucatinib can be decreased when combined with Hydroxyzine.
Alprazolam Alprazolam The metabolism of Tucatinib can be decreased when combined with Alprazolam.
Triazolam Triazolam The metabolism of Tucatinib can be decreased when combined with Triazolam.
Trimethoprim Trimethoprim The metabolism of Tucatinib can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The metabolism of Tucatinib can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Tucatinib can be decreased when combined with Nifedipine.
Verapamil Verapamil The metabolism of Tucatinib can be decreased when combined with Verapamil.
Cisplatin Injection Cisplatin Injection The serum concentration of Cisplatin can be increased when it is combined with Tucatinib.
Piroxicam Piroxicam The metabolism of Tucatinib can be decreased when combined with Piroxicam.
Etoposide Etoposide Etoposide may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Glyburide Glyburide The metabolism of Tucatinib can be decreased when combined with Glyburide.
Indapamide Indapamide The metabolism of Tucatinib can be decreased when combined with Indapamide.
Gemfibrozil Gemfibrozil The metabolism of Tucatinib can be decreased when combined with Gemfibrozil.
Ketoprofen Ketoprofen The metabolism of Tucatinib can be decreased when combined with Ketoprofen.
Pimozide Pimozide The metabolism of Tucatinib can be decreased when combined with Pimozide.
Amiodarone Amiodarone The metabolism of Tucatinib can be decreased when combined with Amiodarone.
Buspirone Buspirone The metabolism of Tucatinib can be decreased when combined with Buspirone.
Lovastatin Lovastatin The metabolism of Tucatinib can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The excretion of Ciprofloxacin can be decreased when combined with Tucatinib.
Diclofenac Diclofenac The metabolism of Tucatinib can be decreased when combined with Diclofenac.
Nimodipine Nimodipine The metabolism of Tucatinib can be decreased when combined with Nimodipine.
Clozapine Clozapine The metabolism of Tucatinib can be decreased when combined with Clozapine.
Estazolam Estazolam The metabolism of Tucatinib can be decreased when combined with Estazolam.
Clarithromycin Clarithromycin The metabolism of Tucatinib can be decreased when combined with Clarithromycin.
Felodipine Felodipine The metabolism of Tucatinib can be decreased when combined with Felodipine.
Pravastatin Pravastatin Pravastatin may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Simvastatin Simvastatin Simvastatin may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Amlodipine Amlodipine The metabolism of Tucatinib can be decreased when combined with Amlodipine.
Teniposide Injection Teniposide Injection The metabolism of Tucatinib can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Tucatinib can be decreased when combined with Itraconazole.
Atovaquone Atovaquone The metabolism of Tucatinib can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Tucatinib can be decreased when combined with Rifabutin.
Bisoprolol Bisoprolol Bisoprolol may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Zolpidem Zolpidem The metabolism of Tucatinib can be decreased when combined with Zolpidem.
Doxazosin Doxazosin The metabolism of Tucatinib can be decreased when combined with Doxazosin.
Isradipine Isradipine The metabolism of Tucatinib can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Tucatinib can be decreased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Tucatinib can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Tucatinib can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The metabolism of Tucatinib can be decreased when combined with Venlafaxine.
Famciclovir Famciclovir The metabolism of Tucatinib can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine The metabolism of Tucatinib can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Tucatinib can be decreased when combined with Nefazodone.
Lamotrigine Lamotrigine The metabolism of Tucatinib can be decreased when combined with Lamotrigine.
Losartan Losartan The metabolism of Tucatinib can be decreased when combined with Losartan.
Tramadol Tramadol The metabolism of Tucatinib can be decreased when combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The metabolism of Tucatinib can be decreased when combined with Vinorelbine.
Lansoprazole Lansoprazole The metabolism of Tucatinib can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Tucatinib can be decreased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Tucatinib can be decreased when combined with Nicardipine.
Ticlopidine Ticlopidine The metabolism of Tucatinib can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir Saquinavir may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Metformin Metformin The excretion of Metformin can be decreased when combined with Tucatinib.
Nisoldipine Nisoldipine The metabolism of Tucatinib can be decreased when combined with Nisoldipine.
Lamivudine Lamivudine The serum concentration of Lamivudine can be increased when it is combined with Tucatinib.
Anastrozole Anastrozole The metabolism of Tucatinib can be decreased when combined with Anastrozole.
Gemcitabine Injection Gemcitabine Injection Tucatinib may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Indinavir Indinavir The metabolism of Tucatinib can be decreased when combined with Indinavir.
Ritonavir Ritonavir The metabolism of Tucatinib can be decreased when combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Tucatinib can be decreased when combined with Docetaxel.
Clomipramine Clomipramine The metabolism of Tucatinib can be decreased when combined with Clomipramine.
Zafirlukast Zafirlukast The metabolism of Tucatinib can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The metabolism of Tucatinib can be decreased when combined with Mirtazapine.
Zileuton Zileuton The metabolism of Tucatinib can be decreased when combined with Zileuton.
Pramipexole Pramipexole The serum concentration of Pramipexole can be increased when it is combined with Tucatinib.
Donepezil Donepezil The metabolism of Tucatinib can be decreased when combined with Donepezil.
Nelfinavir Nelfinavir The metabolism of Tucatinib can be decreased when combined with Nelfinavir.
Fexofenadine Fexofenadine Fexofenadine may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Azithromycin Azithromycin The metabolism of Tucatinib can be decreased when combined with Azithromycin.
Loratadine Loratadine The metabolism of Tucatinib can be decreased when combined with Loratadine.
Carvedilol Carvedilol The metabolism of Tucatinib can be decreased when combined with Carvedilol.
Nilutamide Nilutamide The metabolism of Tucatinib can be decreased when combined with Nilutamide.
Flutamide Flutamide The metabolism of Tucatinib can be decreased when combined with Flutamide.
Selegiline Selegiline The metabolism of Tucatinib can be decreased when combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Tucatinib can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Tucatinib can be decreased when combined with Sertraline.
Propafenone Propafenone The metabolism of Tucatinib can be decreased when combined with Propafenone.
Letrozole Letrozole The metabolism of Tucatinib can be decreased when combined with Letrozole.
Raloxifene Raloxifene The metabolism of Tucatinib can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Tucatinib can be decreased when combined with Irbesartan.
Tamsulosin Tamsulosin The metabolism of Tucatinib can be decreased when combined with Tamsulosin.
Finasteride Finasteride The metabolism of Tucatinib can be decreased when combined with Finasteride.
Quetiapine Quetiapine The metabolism of Tucatinib can be decreased when combined with Quetiapine.
Paroxetine Paroxetine The metabolism of Tucatinib can be decreased when combined with Paroxetine.
Citalopram Citalopram The metabolism of Tucatinib can be decreased when combined with Citalopram.
Efavirenz Efavirenz The metabolism of Tucatinib can be decreased when combined with Efavirenz.
Sildenafil Sildenafil Sildenafil may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Pioglitazone Pioglitazone The metabolism of Tucatinib can be decreased when combined with Pioglitazone.
Celecoxib Celecoxib The metabolism of Tucatinib can be decreased when combined with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Tucatinib can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine The metabolism of Tucatinib can be decreased when combined with Tolterodine.
Nateglinide Nateglinide The metabolism of Tucatinib can be decreased when combined with Nateglinide.
Galantamine Galantamine The metabolism of Tucatinib can be decreased when combined with Galantamine.
Rabeprazole Rabeprazole The metabolism of Tucatinib can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Tucatinib can be decreased when combined with Terbinafine.

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