Neratinib

Generic name: Pronounced as (ne ra' ti nib)
Brand names
  • Nerlynx®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 05/15/2020

Neratinib is used to treat a certain type of hormone receptor-positive breast cancer (breast cancer that depends on hormones such as estrogen to grow) in adults after treatment with trastuzumab (Herceptin) and other medications. Neratinib is used along with capecitabine (Xeloda) to treat a certain type of advanced hormone receptor-positive breast cancer or breast cancer that has spread to other parts of the body after treatment with at least two other medications. Neratinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells.

Neratinib comes as a tablet to take by mouth. When neratinib is taken alone to treat breast cancer, it is usually taken with food once daily for one year. When neratinib is taken with capecitabine to treat advanced breast cancer or breast cancer that has spread to other parts of the body, it is usually taken once daily with food on days 1 to 21 of a 21-day cycle until your condition worsens or you develop serious side effects. Take neratinib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take neratinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them.

Your doctor may decrease your dose or temporarily or permanently stop your treatment of neratinib during your treatment. This depends on how well the medication works for you and the side effects you experience. Talk to your doctor about how you are feeling during your treatment. Continue to take neratinib even if you feel well. Do not stop taking neratinib without talking to your doctor.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking neratinib,

  • tell your doctor and pharmacist if you are allergic to neratinib, any other medications, or any of the ingredients in neratinib tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: certain antibiotics including as ciprofloxacin (Cipro), clarithromycin (Biaxin, in Prevpac), erythromycin (E.E.S., E-Mycin, Erythrocin), and troleandomycin (no longer available in U.S.); certain antifungals including clotrimazole (Mycelex), fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), and voriconazole (Vfend); aprepitant (Emend); bosentan (Tracleer); certain calcium channel blockers including diltiazem (Cardizem, Tiazac, others) and verapamil (Calan, Verelan, others); cobicistat (Tybost); conivaptan (Vaprisol); crizotinib (Xalkori); cyclosporine (Gengraf, Neoral, Sandimmune); dabigatran (Pradaxa); digoxin (Lanoxin); dronedarone (Multaq); enzalutamide (Xtandi); fexofenadine (Allegra); fluvoxamine (Luvox); idelalisib (Zydelig); imatinib (Gleevec); certain medications for hepatitis C including boceprevir (no longer available in U.S., Victrelis), dasabuvir (in Viekira Pak), ombitasvir (in Technivie, in Viekira XR), and paritaprevir (in Technivie, in Viekira XR); certain medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) including efavirenz (Sustiva, in Atripla), elvitegravir (in Genvoya, in Stribild), etravirine (Intelence), indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), saquinavir (Invirase), and tipranavir (Aptivus); mitotane (Lysodren); modafinil (Provigil); nefazodone; proton pump inhibitors such as esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole (AcipHex); rifampin (Rifadin, Rimactane, in Rifater); and certain medications for seizures including carbamazepine (Carbatrol, Epitol, Tegretol) and phenytoin (Dilantin, Phenytek). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with neratinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • if you are taking an antacid, take it at least 3 hours before or 3 hours after taking neratinib.

  • if you are taking neratinib and a medication for indigestion, heartburn, or ulcers (an H2 blocker) such as cimetidine, famotidine (Pepcid, in Duexis), nizatidine (Axid), or ranitidine (Zantac), take neratinib at least 2 hours before or at least 10 hours after taking the H2 blocker.

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you have or have ever had liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or if you plan on fathering a child. You should not become pregnant while you are taking neratinib. If you are female, you will need to take a pregnancy test before you start treatment and should use birth control to prevent pregnancy during your treatment with neratinib and for at least 1 month after taking the final dose. If you are a male, you and your female partner should use birth control during your treatment with neratinib and continue for 3 months after your final dose. Talk to your doctor about birth control methods that you can use during your treatment. If you become pregnant while taking neratinib, call your doctor immediately. Neratinib may harm the fetus.

  • tell your doctor if you are breastfeeding or plan to breastfeed. You should not breastfeed while taking neratinib and for up to 1 month after your final dose.

  • you should know that neratinib often causes diarrhea, which can be severe. Your doctor will probably tell you to take loperamide (Imodium AD), an anti-diarrhea medication, to prevent dehydration (loss of too much water from your body) for the first 56 days of your treatment with neratinib. After 56 days of treatment, your doctor will adjust your loperamide dose so that you have 1 to 2 bowel movements every day while taking neratinib. Your doctor may also tell you to drink plenty of liquids, make changes in your diet, or take other medications to control the diarrhea. Call your doctor immediately if you have severe diarrhea (more than 2 bowel movements in 1 day or diarrhea that does not stop) or diarrhea along with weakness, dizziness, or fever while taking neratinib. Call your doctor immediately if you experience any of the following symptoms of dehydration: extreme thirst, dry mouth and/or skin, decreased urination, or fast heartbeat.

Do not eat grapefruit or drink grapefruit juice while taking this medication.

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Neratinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • diarrhea

    • stomach pain

    • heartburn

    • bloating

    • mouth ulcers

    • loss of appetite

    • weight loss

    • nose bleeding

    • nail problems or changes

    • muscle spasms

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the SPECIAL PRECAUTIONS section, call your doctor immediately:

    • yellow eyes and skin

    • dark urine

    • pain or discomfort in the right upper stomach area

    • tiredness

    • nausea

    • vomiting

    • rash

    • fever, difficulty urinating, pain when urinating, and other signs of infection

  • Neratinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • diarrhea

  • nausea

  • vomiting

  • stomach pain

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to neratinib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Delavirdine Delavirdine The serum concentration of Neratinib can be increased when it is combined with Delavirdine.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Neratinib can be decreased when combined with Erythromycin.
Fenofibrate Fenofibrate The metabolism of Neratinib can be decreased when combined with Fenofibrate.
Methylergonovine Methylergonovine The metabolism of Neratinib can be decreased when combined with Methylergometrine.
Paregoric Paregoric The serum concentration of Morphine can be increased when it is combined with Neratinib.
Tacrolimus Tacrolimus The metabolism of Neratinib can be decreased when combined with Tacrolimus.
Triamcinolone Triamcinolone The metabolism of Neratinib can be increased when combined with Triamcinolone.
Doxycycline Injection Doxycycline Injection The metabolism of Neratinib can be decreased when combined with Doxycycline.
Fluconazole Injection Fluconazole Injection The metabolism of Neratinib can be decreased when combined with Fluconazole.
Meperidine Injection Meperidine Injection The metabolism of Neratinib can be increased when combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Neratinib can be increased when combined with Methylprednisolone.
Metronidazole Injection Metronidazole Injection The metabolism of Neratinib can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The serum concentration of Morphine can be increased when it is combined with Neratinib.
Cyclosporine Cyclosporine The serum concentration of Cyclosporine can be increased when it is combined with Neratinib.
Orlistat Orlistat The metabolism of Neratinib can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Neratinib can be increased when combined with Oxcarbazepine.
Anakinra Anakinra The metabolism of Neratinib can be increased when combined with Anakinra.
Trimipramine Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Neratinib.
Etanercept Injection Etanercept Injection The metabolism of Neratinib can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Neratinib can be increased when combined with Modafinil.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Neratinib.
Sirolimus Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Neratinib.
Epinephrine Injection Epinephrine Injection The metabolism of Neratinib can be decreased when combined with Epinephrine.
Adalimumab Injection Adalimumab Injection The metabolism of Neratinib can be increased when combined with Adalimumab.
Teriparatide Injection Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Neratinib.
Atazanavir Atazanavir The serum concentration of Neratinib can be increased when it is combined with Atazanavir.
Mefloquine Mefloquine The metabolism of Neratinib can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Neratinib can be decreased when combined with Rosuvastatin.
Vardenafil Vardenafil The serum concentration of Vardenafil can be increased when it is combined with Neratinib.
Aprepitant Aprepitant The metabolism of Neratinib can be decreased when combined with Aprepitant.
Tegaserod Tegaserod The serum concentration of Tegaserod can be increased when it is combined with Neratinib.
Progesterone Progesterone The metabolism of Neratinib can be increased when combined with Progesterone.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Neratinib.
Infliximab Injection Infliximab Injection The metabolism of Neratinib can be increased when combined with Infliximab.
Rifaximin Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Neratinib.
Duloxetine Duloxetine The metabolism of Neratinib can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Neratinib can be decreased when combined with Norethisterone.
Bosentan Bosentan The metabolism of Neratinib can be increased when combined with Bosentan.
Erlotinib Erlotinib The metabolism of Neratinib can be decreased when combined with Erlotinib.
Voriconazole Voriconazole The serum concentration of Neratinib can be increased when it is combined with Voriconazole.
Deferasirox Deferasirox The metabolism of Neratinib can be increased when combined with Deferasirox.
Tipranavir Tipranavir The serum concentration of Tipranavir can be increased when it is combined with Neratinib.
Felbamate Felbamate The metabolism of Neratinib can be increased when combined with Felbamate.
Ranolazine Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Neratinib.
Abatacept Injection Abatacept Injection The metabolism of Neratinib can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Neratinib can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Neratinib.
Gefitinib Gefitinib The metabolism of Neratinib can be decreased when combined with Gefitinib.
Paliperidone Paliperidone The serum concentration of Paliperidone can be increased when it is combined with Neratinib.
Bortezomib Bortezomib The serum concentration of Bortezomib can be increased when it is combined with Neratinib.
Posaconazole Posaconazole The serum concentration of Posaconazole can be increased when it is combined with Neratinib.
Primaquine Primaquine The metabolism of Neratinib can be decreased when combined with Primaquine.
Darunavir Darunavir The serum concentration of Neratinib can be increased when it is combined with Darunavir.
Sorafenib Sorafenib The metabolism of Neratinib can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Neratinib can be decreased when combined with Sunitinib.
Lapatinib Lapatinib The metabolism of Neratinib can be decreased when combined with Lapatinib.
Dasatinib Dasatinib The serum concentration of Dasatinib can be increased when it is combined with Neratinib.
Armodafinil Armodafinil The metabolism of Neratinib can be increased when combined with Armodafinil.
Ivermectin Ivermectin The metabolism of Neratinib can be increased when combined with Ivermectin.
Temsirolimus Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Neratinib.
Nilotinib Nilotinib The serum concentration of Neratinib can be increased when it is combined with Nilotinib.
Toremifene Toremifene The serum concentration of Toremifene can be increased when it is combined with Neratinib.
Bexarotene Bexarotene The metabolism of Neratinib can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Neratinib can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Neratinib can be decreased when combined with Chloramphenicol.
Etravirine Etravirine The metabolism of Neratinib can be increased when combined with Etravirine.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Neratinib can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The metabolism of Neratinib can be decreased when combined with Desvenlafaxine.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Neratinib.
Pilocarpine Pilocarpine The metabolism of Neratinib can be decreased when combined with Pilocarpine.
Certolizumab Injection Certolizumab Injection The metabolism of Neratinib can be increased when combined with Certolizumab pegol.
Mitotane Mitotane The metabolism of Neratinib can be increased when combined with Mitotane.
Rufinamide Rufinamide The metabolism of Neratinib can be increased when combined with Rufinamide.
Silodosin Silodosin The serum concentration of Silodosin can be increased when it is combined with Neratinib.
Midazolam Midazolam The metabolism of Neratinib can be decreased when combined with Midazolam.
Milnacipran Milnacipran The metabolism of Neratinib can be decreased when combined with Milnacipran.
Lacosamide Lacosamide The metabolism of Neratinib can be decreased when combined with Lacosamide.
Everolimus Everolimus The serum concentration of Everolimus can be increased when it is combined with Neratinib.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Neratinib.
Dronedarone Dronedarone The serum concentration of Neratinib can be increased when it is combined with Dronedarone.
Romidepsin Injection Romidepsin Injection The serum concentration of Romidepsin can be increased when it is combined with Neratinib.
Topotecan Topotecan The serum concentration of Topotecan can be increased when it is combined with Neratinib.
Golimumab Injection Golimumab Injection The metabolism of Neratinib can be increased when combined with Golimumab.
Pazopanib Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Neratinib.
Albendazole Albendazole The metabolism of Neratinib can be decreased when combined with Albendazole.
Tocilizumab Injection Tocilizumab Injection The metabolism of Neratinib can be increased when combined with Tocilizumab.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Cabazitaxel can be increased when it is combined with Neratinib.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be increased when combined with Neratinib.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Neratinib can be decreased when combined with Aldesleukin.
Roflumilast Roflumilast The metabolism of Neratinib can be decreased when combined with Roflumilast.
Linagliptin Linagliptin The metabolism of Linagliptin can be decreased when combined with Neratinib.
Rilpivirine Rilpivirine The metabolism of Neratinib can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The metabolism of Glecaprevir can be decreased when combined with Neratinib.
Potassium Iodide Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Neratinib.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Neratinib can be increased when combined with Cyclophosphamide.
Rivaroxaban Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Neratinib.
Ticagrelor Ticagrelor The metabolism of Ticagrelor can be decreased when combined with Neratinib.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Neratinib.
Clobazam Clobazam The metabolism of Clobazam can be increased when combined with Neratinib.
Vemurafenib Vemurafenib The serum concentration of Vemurafenib can be increased when it is combined with Neratinib.
Ivacaftor Ivacaftor The metabolism of Neratinib can be decreased when combined with Ivacaftor.
Axitinib Axitinib The serum concentration of Axitinib can be increased when it is combined with Neratinib.
Crizotinib Crizotinib The metabolism of Crizotinib can be decreased when combined with Neratinib.
Cabergoline Cabergoline The metabolism of Neratinib can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The serum concentration of Neratinib can be increased when it is combined with Naloxone.
Ambrisentan Ambrisentan The serum concentration of Ambrisentan can be increased when it is combined with Neratinib.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Neratinib.
Enzalutamide Enzalutamide The metabolism of Neratinib can be increased when combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Neratinib.
Regorafenib Regorafenib The metabolism of Neratinib can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Neratinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Neratinib can be increased when combined with Corticotropin.
Pomalidomide Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Neratinib.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be increased when it is combined with Neratinib.
Apixaban Apixaban The serum concentration of Apixaban can be increased when it is combined with Neratinib.
Canagliflozin Canagliflozin The serum concentration of Canagliflozin can be increased when it is combined with Neratinib.
Dabrafenib Dabrafenib The serum concentration of Dabrafenib can be increased when it is combined with Neratinib.
Trametinib Trametinib The metabolism of Neratinib can be increased when combined with Trametinib.
Dolutegravir Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Neratinib.
Afatinib Afatinib The serum concentration of Afatinib can be increased when it is combined with Neratinib.
Perampanel Perampanel The metabolism of Neratinib can be increased when combined with Perampanel.
Lomitapide Lomitapide The metabolism of Neratinib can be decreased when combined with Lomitapide.
Simeprevir Simeprevir The metabolism of Simeprevir can be decreased when combined with Neratinib.
Sofosbuvir Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Neratinib.
Apremilast Apremilast The metabolism of Neratinib can be increased when combined with Apremilast.
Ceritinib Ceritinib The serum concentration of Ceritinib can be increased when it is combined with Neratinib.
Siltuximab Injection Siltuximab Injection The metabolism of Neratinib can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Neratinib can be increased when combined with Eslicarbazepine.
Belinostat Injection Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Neratinib.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Neratinib.
Testosterone Injection Testosterone Injection The metabolism of Neratinib can be increased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Neratinib can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The metabolism of Neratinib can be decreased when combined with Vorapaxar.
Suvorexant Suvorexant The metabolism of Neratinib can be decreased when combined with Suvorexant.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Neratinib.
Olaparib Olaparib The metabolism of Neratinib can be decreased when combined with Olaparib.
Tasimelteon Tasimelteon The metabolism of Neratinib can be decreased when combined with Tasimelteon.
Lanreotide Injection Lanreotide Injection The metabolism of Neratinib can be decreased when combined with Lanreotide.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Neratinib.
Secukinumab Injection Secukinumab Injection The metabolism of Neratinib can be increased when combined with Secukinumab.
Palbociclib Palbociclib The metabolism of Neratinib can be decreased when combined with Palbociclib.
Lenvatinib Lenvatinib The metabolism of Lenvatinib can be increased when combined with Neratinib.
Naloxegol Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Neratinib.
Panobinostat Panobinostat The serum concentration of Panobinostat can be increased when it is combined with Neratinib.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Neratinib.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Neratinib can be increased when combined with Isavuconazonium.
Prednisolone Prednisolone The metabolism of Neratinib can be increased when combined with Prednisolone.
Ziprasidone Injection Ziprasidone Injection The metabolism of Neratinib can be decreased when combined with Ziprasidone.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Neratinib.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Neratinib.
Rifapentine Rifapentine The metabolism of Neratinib can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Neratinib can be increased when combined with Lesinurad.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Neratinib can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Neratinib can be increased when combined with Dexamethasone.
Venetoclax Venetoclax The serum concentration of Venetoclax can be increased when it is combined with Neratinib.
Cobicistat Cobicistat The serum concentration of Neratinib can be increased when it is combined with Cobicistat.
Selexipag Selexipag The serum concentration of Selexipag can be increased when it is combined with Neratinib.
Rucaparib Rucaparib The metabolism of Rucaparib can be decreased when combined with Neratinib.
Ribociclib Ribociclib The serum concentration of Neratinib can be increased when it is combined with Ribociclib.
Parathyroid Hormone Injection Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Neratinib.
Brigatinib Brigatinib The metabolism of Neratinib can be increased when combined with Brigatinib.
Deflazacort Deflazacort The metabolism of Neratinib can be increased when combined with Deflazacort.
Sarilumab Injection Sarilumab Injection The metabolism of Neratinib can be increased when combined with Sarilumab.
Midostaurin Midostaurin The serum concentration of Neratinib can be increased when it is combined with Midostaurin.
Abaloparatide Injection Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Neratinib.
Enasidenib Enasidenib The metabolism of Neratinib can be increased when combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Neratinib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Neratinib can be increased when combined with Fosaprepitant.
Copanlisib Injection Copanlisib Injection The serum concentration of Copanlisib can be increased when it is combined with Neratinib.
Abemaciclib Abemaciclib The serum concentration of Abemaciclib can be increased when it is combined with Neratinib.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Neratinib.
Acalabrutinib Acalabrutinib The metabolism of Neratinib can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Neratinib can be decreased when combined with Letermovir.
Ertugliflozin Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Neratinib.
Buprenorphine Injection Buprenorphine Injection The metabolism of Neratinib can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The metabolism of Neratinib can be increased when combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Neratinib can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Neratinib.
Baricitinib Baricitinib The serum concentration of Baricitinib can be increased when it is combined with Neratinib.
Eliglustat Eliglustat The serum concentration of Eliglustat can be increased when it is combined with Neratinib.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Neratinib.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be increased when combined with Neratinib.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Neratinib.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Neratinib.
Dacomitinib Dacomitinib The serum concentration of Dacomitinib can be increased when it is combined with Neratinib.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Neratinib.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Neratinib.
Stiripentol Stiripentol The serum concentration of Neratinib can be increased when it is combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Neratinib.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Neratinib.
Glasdegib Glasdegib The serum concentration of Glasdegib can be increased when it is combined with Neratinib.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Neratinib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Neratinib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Neratinib can be increased when combined with Paclitaxel.
Rifamycin Rifamycin The metabolism of Rifamycin can be increased when combined with Neratinib.
Prucalopride Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Neratinib.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Neratinib can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Neratinib can be decreased when combined with Siponimod.
Alpelisib Alpelisib The metabolism of Neratinib can be increased when combined with Alpelisib.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Neratinib.
Triclabendazole Triclabendazole The metabolism of Neratinib can be decreased when combined with Triclabendazole.
Pitolisant Pitolisant The serum concentration of Neratinib can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Neratinib.
Lefamulin Lefamulin Neratinib may decrease the excretion rate of Lefamulin which could result in a higher serum level.
Phenytoin Injection Phenytoin Injection The metabolism of Neratinib can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Neratinib can be increased when combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Neratinib.
Voxelotor Voxelotor The serum concentration of Neratinib can be increased when it is combined with Voxelotor.
Lasmiditan Lasmiditan The serum concentration of Lasmiditan can be increased when it is combined with Neratinib.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Neratinib.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Neratinib.
Cenobamate Cenobamate The serum concentration of Neratinib can be decreased when it is combined with Cenobamate.
Selumetinib Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Neratinib.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Neratinib.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Neratinib.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Neratinib.
Ripretinib Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Neratinib.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Neratinib.
Fostemsavir Fostemsavir The serum concentration of Fostemsavir can be increased when it is combined with Neratinib.
Octreotide Octreotide The serum concentration of Neratinib can be increased when it is combined with Octreotide.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Neratinib.
Pralsetinib Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Neratinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Neratinib can be decreased when it is combined with Satralizumab.
Relugolix Relugolix The serum concentration of Relugolix can be increased when it is combined with Neratinib.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Neratinib can be decreased when combined with Drospirenone.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Neratinib can be increased when combined with Vitamin E.
Phenobarbital Phenobarbital The metabolism of Neratinib can be increased when combined with Phenobarbital.
Primidone Primidone The metabolism of Neratinib can be increased when combined with Primidone.
Chlorpromazine Chlorpromazine The metabolism of Neratinib can be increased when combined with Chlorpromazine.
Diazepam Diazepam The metabolism of Neratinib can be decreased when combined with Diazepam.
Lorazepam Lorazepam The metabolism of Neratinib can be decreased when combined with Lorazepam.
Bromocriptine Bromocriptine The metabolism of Neratinib can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Neratinib can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Neratinib can be decreased when combined with Phenelzine.
Tetracycline Tetracycline The metabolism of Neratinib can be decreased when combined with Tetracycline.
Prochlorperazine Prochlorperazine The metabolism of Neratinib can be decreased when combined with Prochlorperazine.
Methadone Methadone The metabolism of Neratinib can be increased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Neratinib can be decreased when combined with Oxybutynin.
Orphenadrine Orphenadrine The metabolism of Neratinib can be decreased when combined with Orphenadrine.
Phentermine Phentermine The metabolism of Neratinib can be decreased when combined with Phentermine.
Hydrocortisone Hydrocortisone The metabolism of Neratinib can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Neratinib.
Dactinomycin Dactinomycin The serum concentration of Dactinomycin can be increased when it is combined with Neratinib.
Carbamazepine Carbamazepine The metabolism of Neratinib can be increased when combined with Carbamazepine.
Hydralazine Hydralazine The metabolism of Neratinib can be decreased when combined with Hydralazine.
Cimetidine Cimetidine The metabolism of Neratinib can be decreased when combined with Cimetidine.
Warfarin Warfarin The metabolism of Neratinib can be increased when combined with Warfarin.
Loperamide Loperamide The serum concentration of Loperamide can be increased when it is combined with Neratinib.
Daunorubicin Daunorubicin The metabolism of Neratinib can be decreased when combined with Daunorubicin.
Griseofulvin Griseofulvin The metabolism of Neratinib can be increased when combined with Griseofulvin.
Digoxin Digoxin Neratinib may decrease the excretion rate of Digoxin which could result in a higher serum level.
Quinine Quinine The metabolism of Quinine can be increased when combined with Neratinib.
Calcitriol Calcitriol The metabolism of Neratinib can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Neratinib can be increased when combined with Sulfinpyrazone.
Secobarbital Secobarbital The metabolism of Neratinib can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Neratinib can be decreased when combined with Desipramine.
Imipramine Imipramine The serum concentration of Imipramine can be increased when it is combined with Neratinib.
Probenecid Probenecid The metabolism of Neratinib can be increased when combined with Probenecid.
Quinidine Quinidine The serum concentration of Quinidine can be increased when it is combined with Neratinib.
Isoniazid Isoniazid The metabolism of Neratinib can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Neratinib can be increased when combined with Rifampicin.
Valproic Acid Valproic Acid The metabolism of Neratinib can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Neratinib can be increased when combined with Tamoxifen.
Levothyroxine Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Neratinib.
Liothyronine Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Neratinib.
Methimazole Methimazole The serum concentration of Methimazole can be increased when it is combined with Neratinib.
Propylthiouracil Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Neratinib.
Niacin Niacin The metabolism of Neratinib can be decreased when combined with Niacin.
Danazol Danazol The metabolism of Neratinib can be decreased when combined with Danazol.
Nortriptyline Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Neratinib.
Amphotericin B Injection Amphotericin B Injection The metabolism of Neratinib can be decreased when combined with Amphotericin B.
Clomiphene Clomiphene The serum concentration of Clomifene can be increased when it is combined with Neratinib.
Colchicine Colchicine The serum concentration of Colchicine can be increased when it is combined with Neratinib.
Cephalexin Cephalexin The metabolism of Neratinib can be decreased when combined with Cephalexin.
Acetazolamide Acetazolamide The metabolism of Neratinib can be decreased when combined with Acetazolamide.
Calcitonin Salmon Injection Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Neratinib.
Ketoconazole Ketoconazole The serum concentration of Neratinib can be increased when it is combined with Ketoconazole.
Vincristine Injection Vincristine Injection The excretion of Vincristine can be decreased when combined with Neratinib.
Vinblastine Vinblastine The serum concentration of Vinblastine can be increased when it is combined with Neratinib.
Metoprolol Metoprolol The metabolism of Neratinib can be decreased when combined with Metoprolol.
Diltiazem Diltiazem The metabolism of Neratinib can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Neratinib can be increased when combined with Nifedipine.
Verapamil Verapamil The metabolism of Neratinib can be decreased when combined with Verapamil.
Etoposide Etoposide The serum concentration of Etoposide can be increased when it is combined with Neratinib.
Glyburide Glyburide The metabolism of Neratinib can be decreased when combined with Glyburide.
Dicloxacillin Dicloxacillin The metabolism of Neratinib can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Neratinib can be increased when combined with Nafcillin.
Pimozide Pimozide The metabolism of Neratinib can be decreased when combined with Pimozide.
Amiodarone Amiodarone The metabolism of Neratinib can be decreased when combined with Amiodarone.
Lovastatin Lovastatin The metabolism of Neratinib can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Neratinib can be decreased when combined with Ciprofloxacin.
Clozapine Clozapine The metabolism of Neratinib can be increased when combined with Clozapine.
Clarithromycin Clarithromycin The serum concentration of Neratinib can be increased when it is combined with Clarithromycin.
Felodipine Felodipine The metabolism of Neratinib can be decreased when combined with Felodipine.
Pravastatin Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Neratinib.
Simvastatin Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Neratinib.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Neratinib.
Teniposide Injection Teniposide Injection The metabolism of Neratinib can be decreased when combined with Teniposide.
Itraconazole Itraconazole The serum concentration of Neratinib can be increased when it is combined with Itraconazole.
Rifabutin Rifabutin The metabolism of Neratinib can be increased when combined with Rifabutin.
Bisoprolol Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Neratinib.
Doxazosin Doxazosin The metabolism of Neratinib can be decreased when combined with Doxazosin.
Isradipine Isradipine The metabolism of Neratinib can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Neratinib can be increased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Neratinib can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Neratinib can be decreased when combined with Fluvastatin.
Famciclovir Famciclovir The metabolism of Neratinib can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine The metabolism of Neratinib can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The serum concentration of Neratinib can be increased when it is combined with Nefazodone.
Losartan Losartan The metabolism of Neratinib can be decreased when combined with Losartan.
Lansoprazole Lansoprazole The metabolism of Neratinib can be increased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Neratinib can be increased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Neratinib can be decreased when combined with Nicardipine.
Ticlopidine Ticlopidine The metabolism of Neratinib can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The serum concentration of Saquinavir can be increased when it is combined with Neratinib.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Neratinib.
Ritonavir Ritonavir The serum concentration of Neratinib can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Neratinib can be decreased when combined with Docetaxel.
Zafirlukast Zafirlukast The metabolism of Neratinib can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The metabolism of Neratinib can be decreased when combined with Mirtazapine.
Topiramate Topiramate The metabolism of Neratinib can be increased when combined with Topiramate.
Fexofenadine Fexofenadine The serum concentration of Fexofenadine can be increased when it is combined with Neratinib.
Azithromycin Azithromycin The metabolism of Neratinib can be decreased when combined with Azithromycin.
Bicalutamide Bicalutamide The metabolism of Neratinib can be decreased when combined with Bicalutamide.
Raloxifene Raloxifene The metabolism of Neratinib can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Neratinib can be decreased when combined with Irbesartan.
Paroxetine Paroxetine The metabolism of Neratinib can be decreased when combined with Paroxetine.
Citalopram Citalopram The metabolism of Neratinib can be decreased when combined with Citalopram.
Efavirenz Efavirenz The serum concentration of Neratinib can be increased when it is combined with Efavirenz.
Sildenafil Sildenafil The serum concentration of Sildenafil can be increased when it is combined with Neratinib.
Rabeprazole Rabeprazole The metabolism of Neratinib can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Neratinib can be increased when combined with Terbinafine.

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