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Fluconazole

Fluconazole is an antifungal medicine used to treat yeast (Candida) infections such as vaginal, mouth, throat and esophagus infections, to treat cryptococcal meningitis, and to help prevent candidiasis in bone marrow transplant patients.

Brand names DiflucanFluconazole in Sodium Chloride
Drug class Azole Antifungal
Rx Forms 3
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 104 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

How we combine label and product data →
✓No current FDA shortage listed · checked Oct 4, 2026
Other forms & routes:
Injection
Fluconazole at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Fluconazole (Diflucan), an antifungal that has been a familiar first choice for vaginal yeast infections since about 1990 and is available generically, also treats Candida yeast infections of the mouth, throat and esophagus and cryptococcal meningitis (a fungal infection around the brain), and helps prevent yeast infections in bone marrow transplant patients. It is usually well tolerated, and the side effects people notice are mostly headache, nausea or stomach upset, though rare liver injury and severe skin or allergic reactions can occur. The main thing to check is your other medicines, since combining it with drugs like erythromycin, pimozide or quinidine can cause dangerous heart rhythm problems.

Clinical pearls

  • For a vaginal yeast infection, a single dose is usually the whole treatment, taken with or without food.
  • Higher doses in early pregnancy have been linked to birth defects, so tell your prescriber if you are or could become pregnant.
  • Phenytoin, valproic acid, rifampin, isoniazid and sulfonylurea diabetes medicines were linked to more abnormal liver tests alongside fluconazole.
  • Stop it and get checked for yellow skin or eyes, dark urine, or a rash that spreads, blisters or peels.
How we write & review this content — our editorial policy →
How you get itPrescription only
Comes asTablet, Oral suspension, Injection
Earliest FDA record1990
Companies listing it with the FDA81
FDA label last updatedApr 2, 2026
FDA’s strongest warning (boxed)None on the label

Patient information guide — a plain-language walkthrough of Fluconazole, written from its FDA label.

What Fluconazole is used for

▾

Fluconazole treats several fungal infections, with some uses limited to certain products.

  • Vaginal yeast infections (Candida): Diflucan, fluconazole tablets, and fluconazole products labeled for tablet and suspension.
  • Oropharyngeal (mouth and throat) and esophageal candidiasis: all supported products.
  • Candida urinary tract infections, peritonitis and systemic infections including candidemia, disseminated candidiasis and pneumonia: effective in small open studies.
  • Cryptococcal meningitis: all supported products.
  • Prevention of candidiasis in bone marrow transplant patients receiving chemotherapy and/or radiation: all supported products.

How Fluconazole works

▾

Fluconazole blocks a fungal enzyme (lanosterol 14-α-demethylase) that makes ergosterol, an essential part of fungal cell membranes. Without normal sterols, fungal growth slows. Human cells are much less sensitive to this block.

Resistance is possible. Some fungi change the target enzyme or pump the drug out of their cells. Candida krusei is considered resistant.

Fluconazole dosage

▾

Fluconazole comes as a tablet, an oral suspension and an IV injection. Oral forms can be taken with or without food. Vaginal yeast infections are treated with one single oral dose. Other infections are usually treated once daily, often with a larger first-day dose, and the length of treatment depends on the infection and your response.

  • The daily dose is the same by mouth or IV.
  • Take the full course, since stopping early may lead to recurrence.
  • People with AIDS and cryptococcal meningitis or recurrent mouth and throat candidiasis often need maintenance therapy.

Dosing details from the FDA-approved label

From the Fluconazole prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Vaginal candidiasis (adults)
    • 150 mg as a single oral dose
    • No need to adjust single dose therapy for impaired renal function
  • Oropharyngeal candidiasis (adults)
    • 200 mg on the first day, followed by 100 mg once daily
    • Treat for at least 2 weeks to decrease the likelihood of relapse
  • Esophageal candidiasis (adults)
    • 200 mg on the first day, followed by 100 mg once daily
    • Maximum: Doses up to 400 mg/day may be used
    • Treat for a minimum of three weeks and at least two weeks after symptoms resolve
  • Systemic Candida infections (adults)
    • Optimal dosage and duration have not been established
    • Doses of up to 400 mg daily have been used in open, noncomparative studies
  • Candida urinary tract infections and peritonitis (adults)
    • Daily doses of 50 to 200 mg have been used in open, noncomparative studies
  • Acute cryptococcal meningitis (adults)
    • 400 mg on the first day, followed by 200 mg once daily
    • 400 mg once daily may be used based on medical judgment
    • Treat 10 to 12 weeks after cerebrospinal fluid becomes culture negative
  • Suppression of relapse of cryptococcal meningitis in adults with AIDS
    • 200 mg once daily
  • Prophylaxis in bone marrow transplantation (adults)
    • 400 mg once daily
    • If severe granulocytopenia is anticipated, start several days before neutropenia and continue 7 days after neutrophils rise above 1000 cells/mm3
  • Oropharyngeal candidiasis (pediatric patients 6 months and older)
    • 6 mg/kg on the first day, followed by 3 mg/kg once daily
    • Treat for at least 2 weeks
  • Impaired renal function, multiple doses
    • Initial loading dose of 50 mg to 400 mg, then daily dose by creatinine clearance: >50 mL/min 100%
    • ≤50 mL/min (no dialysis) 50%
    • Hemodialysis 100% after each hemodialysis
    • Kidney adjustment based on creatinine clearance
Read the label’s full dosing text

DOSAGE AND ADMINISTRATION Dosage and Administration in Adults Single Dose Vaginal candidiasis The recommended dosage of fluconazole for vaginal candidiasis is 150 mg as a single oral dose. Multiple Dose SINCE ORAL ABSORPTION IS RAPID AND ALMOST COMPLETE, THE DAILY DOSE OF FLUCONAZOLE IS THE SAME FOR ORAL (TABLETS AND SUSPENSION) AND INTRAVENOUS ADMINISTRATION. In general, a loading dose of twice the daily dose is recommended on the first day of therapy to result in plasma concentrations close to steady-state by the second day of therapy. The daily dose of fluconazole for the treatment of infections other than vaginal candidiasis should be based on the infecting organism and the patient's response to therapy. Treatment should be continued until clinical parameters or laboratory tests indicate that active fungal infection has subsided. An inadequate period of treatment may lead to recurrence of active infection. Patients with AIDS and cryptococcal meningitis or recurrent oropharyngeal candidiasis usually require maintenance therapy to prevent relapse. Oropharyngeal candidiasis The recommended dosage of fluconazole for oropharyngeal candidiasis is 200 mg on the first day, followed by 100 mg once daily. Clinical evidence of oropharyngeal candidiasis generally resolves within several days, but treatment should be continued for at least 2 weeks to decrease the likelihood of relapse. Esophageal candidiasis The recommended dosage of fluconazole for esophageal candidiasis is 200 mg on the first day, followed by 100 mg once daily. Doses up to 400 mg/day may be used, based on medical judgment of the patient's response to therapy. Patients with esophageal candidiasis should be treated for a minimum of three weeks and for at least two weeks following resolution of symptoms. Systemic Candida infections For systemic Candida infections including candidemia, disseminated candidiasis, and pneumonia, optimal therapeutic dosage and duration of therapy have not been established. In open, noncomparative studies of small numbers of patients, doses of up to 400 mg daily have been used. Urinary tract infections and peritonitis For the treatment of Candida urinary tract infections and peritonitis, daily doses of 50 to 200 mg have been used in open, noncomparative studies of small numbers of patients.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Fluconazole side effects

▾

Common side effects

  • Headache
  • Nausea
  • Stomach or abdominal pain
  • Diarrhea
  • Vomiting
  • Skin rash
  • Dizziness
  • Taste changes

When to get medical help

  • Get help right away for signs of a severe allergic reaction, such as swelling of the face or throat, itching or trouble breathing.
  • Call your doctor if you develop a rash, especially one that spreads or blisters, or peeling skin.
  • Call your doctor if you have signs of liver problems, such as yellow skin or eyes, dark urine, or unusual tiredness.
  • Seek help for a fast or irregular heartbeat or fainting, since fluconazole can cause QT prolongation (a heart rhythm change).
  • Report seizures right away.
  • Tell your doctor about unusual bruising, bleeding or frequent infections, which can reflect low blood cell counts.

Fluconazole is generally well tolerated. Common side effects include:

  • Headache
  • Nausea
  • Abdominal pain
  • Diarrhea
  • Vomiting
  • Skin rash
  • Dizziness and taste changes

Call your doctor promptly about a spreading rash, signs of liver problems, allergic reactions, seizures or heart rhythm changes.

Fluconazole warnings and precautions

▾
  • Liver injury: rare but serious, sometimes fatal, mostly in people with serious underlying illness. Use caution with liver disease.
  • Severe skin reactions: including Stevens-Johnson syndrome and toxic epidermal necrolysis.
  • Anaphylaxis: rare severe allergic reaction.
  • Heart rhythm: QT prolongation and torsade de pointes have been reported.
  • Pregnancy: possible fetal harm, especially with high doses in the first trimester.

Fluconazole interactions

▾

Several medicines can clash with fluconazole.

  • Erythromycin, pimozide and quinidine: contraindicated due to heart rhythm risk.
  • Other QT-prolonging drugs processed by CYP3A4: should not be combined.
  • Rifampin, phenytoin, isoniazid, valproic acid and oral sulfonylureas: higher chance of raised liver enzymes.

Interactions listed in the FDA-approved label

From the Fluconazole prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Oral contraceptives (ethinyl estradiol, levonorgestrel): With fluconazole 50 mg daily for 10 days there was no significant difference in AUC (ethinyl estradiol mean increase 6%, levonorgestrel 17%); with 200 mg daily, levonorgestrel AUC rose 25% and ethinyl estradiol AUC 38%, both significantly different from placebo.
  • Oral contraceptive containing ethinyl estradiol and norethindrone (fluconazole 300 mg once weekly): Small increases in mean AUCs: ethinyl estradiol 24% and norethindrone 13% relative to placebo, with no decrease in ethinyl estradiol AUC in any individual subject.
Read the label’s full interactions text

Drug Interaction Studies (See PRECAUTIONS, Drug Interactions) Oral contraceptives: Oral contraceptives were administered as a single dose both before and after the oral administration of fluconazole 50 mg once daily for 10 days in 10 healthy women. There was no significant difference in ethinyl estradiol or levonorgestrel AUC after the administration of 50 mg of fluconazole. The mean increase in ethinyl estradiol AUC was 6% (range: –47 to 108%) and levonorgestrel AUC increased 17% (range: –33 to 141%). In a second study, twenty-five normal females received daily doses of both 200 mg fluconazole tablets or placebo for two, ten-day periods. The treatment cycles were one month apart with all subjects receiving fluconazole during one cycle and placebo during the other. The order of study treatment was random. Single doses of an oral contraceptive tablet containing levonorgestrel and ethinyl estradiol were administered on the final treatment day (Day 10) of both cycles. Following administration of 200 mg of fluconazole, the mean percentage increase of AUC for levonorgestrel compared to placebo was 25% (range: –12 to 82%) and the mean percentage increase for ethinyl estradiol compared to placebo was 38% (range: –11 to 101%). Both of these increases were statistically significantly different from placebo. A third study evaluated the potential interaction of once-weekly dosing of fluconazole 300 mg to 21 normal females taking an oral contraceptive containing ethinyl estradiol and norethindrone. In this placebo-controlled, double-blind, randomized, two-way crossover study carried out over three cycles of oral contraceptive treatment, fluconazole dosing resulted in small increases in the mean AUCs of ethinyl estradiol and norethindrone compared to similar placebo dosing. The mean AUCs of ethinyl estradiol and norethindrone increased by 24% (95% C.I. range: 18 to 31%) and 13% (95% C.I. range: 8 to 18%), respectively, relative to placebo.

Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿81 supplements and herbs with documented Fluconazole interactions, ranked by severity Check Fluconazole against a supplement or herb →

Before taking Fluconazole

▾
  • Do not use if allergic to fluconazole or its ingredients.
  • Use caution if allergic to other azole antifungals.
  • Tell your doctor about liver disease.
  • Kidney problems may require a lower dose.
  • Tell your doctor if you are pregnant or may become pregnant.
  • Children have been treated in clinical trials with a side effect pattern similar to adults.

Fluconazole overdose

▾

Overdose has been reported with hallucinations and paranoid behavior. Treatment is supportive. Fluconazole is largely cleared through the urine, and a 3-hour hemodialysis session lowers blood levels by about 50%.

What Fluconazole does in the body

▾

Fluconazole is active against most Candida albicans, C. glabrata (many isolates are only intermediately susceptible), C. parapsilosis, C. tropicalis and Cryptococcus neoformans. Its action is mainly to slow fungal growth rather than kill the fungus. In healthy volunteers, it had small and inconsistent effects on testosterone and cortisol.

How your body processes Fluconazole

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Over 90% of an oral dose is absorbed, and food does not change exposure. Peak levels occur 1 to 2 hours after an oral dose, and the half-life is about 30 hours. Roughly 80% leaves in urine unchanged, so kidney problems can raise drug levels. It spreads into body fluids, including cerebrospinal fluid.

How to store Fluconazole

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Store tablets below 30°C (86°F). Store dry powder below 30°C (86°F). Store reconstituted suspension between 30°C (86°F) and 5°C (41°F) and discard unused portion after 2 weeks.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

81

Supplements & herbs that interact with Fluconazole

81 supplements and herbal products have documented interactions with Fluconazole in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 4
  • Moderate · 54
  • Minor · 23
ACTIVATED CHARCOAL Major BEER Major SIBERIAN COCKLEBUR Major WINE Major ADRAFINIL Moderate ASHWAGANDHA Moderate BLACK COHOSH Moderate BOLDO Moderate +73 more
Every supplement checked against Fluconazole — ranked by severity The full interaction hub: 4 major · 54 moderate · 23 minor · every one linked to its full report. Check Fluconazole against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

Fluconazole: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Fluconazole — the kind of thing our pharmacy team would talk through with you at the counter.

What is fluconazole used for?

▾
It treats yeast infections such as vaginal, mouth, throat and esophagus infections. It also treats cryptococcal meningitis and helps prevent candidiasis in bone marrow transplant patients. Some uses depend on the product, so check yours with me.

Do I need to take it with food?

▾
No. Oral fluconazole works the same with or without food, so take it whichever is easier for you. Follow your prescriber's directions for how often and for how long.

What side effects should I expect?

▾
Most people tolerate it well. The most common ones are headache, nausea, stomach pain, diarrhea and rash, and these are usually mild to moderate.

When should I call my doctor?

▾
Call if you notice a rash that spreads or blisters, yellow skin or eyes, dark urine, a racing or irregular heartbeat, fainting or seizures. Swelling of the face or trouble breathing needs emergency help.

Can I take it with my other medicines?

▾
Not always. Erythromycin, pimozide and quinidine must not be combined with fluconazole. Always give me your full medication list so I can check for others.

Is it safe in pregnancy?

▾
Tell your doctor if you are or could be pregnant. High doses in early pregnancy have been linked to birth defects, and there may be a risk even with 150 mg doses, though those findings are less certain.

Is Fluconazole available over the counter?

▾
No. Fluconazole is a prescription medicine: every Fluconazole product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Fluconazole first available?

▾
The earliest FDA record we hold for Fluconazole is from 1990: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Fluconazole was first used.

Who makes Fluconazole?

▾
81 companies list Fluconazole products in the FDA's NDC Directory, including Bryant Ranch Prepack, Remedyrepack Inc., A-S Medication Solutions. That count includes repackagers and distributors as well as manufacturers, so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Fluconazole on HelloPharmacist

📊Fluconazole supplement interactions81 checked — ranked by severity 🌿Drug & Supplement CheckerFluconazole vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Fluconazole NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Fluconazole Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Fluconazole forms and strengths (how it comes)

Fluconazole is available in 3 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Tablet

By mouth
Brands Diflucan
How this form is used
What it may be used for
  • Diflucan and fluconazole tablets are used for vaginal yeast infections, oropharyngeal and esophageal candidiasis, and cryptococcal meningitis.
  • Diflucan and fluconazole tablets are also used to decrease candidiasis in bone marrow transplant patients.
Important instructions
  • Fluconazole tablets may be taken without regard to meals.
  • Diflucan and fluconazole tablets treat vaginal candidiasis with a single oral dose.
Available strengths 4 strengths
50 mg 100 mg 150 mg 200 mg
447 FDA-listed product records ⓘ

Oral suspension

By mouth
Brands Diflucan
How this form is used
What it may be used for
  • Fluconazole for oral suspension is used for oropharyngeal and esophageal candidiasis and cryptococcal meningitis.
  • Diflucan (tablets and suspension) is also used for vaginal candidiasis.
  • Fluconazole for oral suspension is also used to decrease candidiasis in bone marrow transplant patients.
Important instructions
  • Diflucan and fluconazole oral suspension are taken by mouth, with a daily dose matching the tablet and IV dose.
  • Oral suspension is typically started with a loading dose of twice the daily dose on day 1.
Available strengths 4 strengths
10 mg/mL 40 mg/mL 350 mg/35 mL 1400 mg/35 mL
32 FDA-listed product records ⓘ

Injection

Into a vein
Brands Fluconazole in Sodium Chloride
How this form is used
What it may be used for
  • Fluconazole in Sodium Chloride Injection is used for oropharyngeal and esophageal candidiasis and cryptococcal meningitis.
  • Fluconazole in Sodium Chloride Injection is also used to decrease candidiasis in bone marrow transplant patients receiving chemotherapy and/or radiation.
Important instructions
  • Fluconazole injection is given through a vein, and its daily dose is the same as the oral dose.
  • Fluconazole injection typically starts with a loading dose of twice the daily dose on day 1.
Available strengths 3 strengths
2 mg/mL 200 mg/100 mL 400 mg/200 mL
31 FDA-listed product records ⓘ

Fluconazole on the U.S. market: products, makers and brands

How Fluconazole appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

81 companies list 528 Fluconazole product records with the FDA, mostly as tablet, oral suspension, injection; the earliest marketing or approval year on record is 1990. Brand names on the directory include Diflucan, Fluconazole in Sodium Chloride; the rest are generics.

3
Dose forms ⓘ
81
Labelers (makers, repackagers, distributors)
3
Brand names
528
FDA-listed product records ⓘ
1990
Earliest FDA record ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (18) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Bryant Ranch Prepack10%
Remedyrepack Inc.7%
A-S Medication Solutions5%
NuCare Pharmaceuticals,Inc.5%
Aurobindo Pharma Limited5%
Golden State Medical Supply, Inc.4%
Other makers64%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Fluconazole is used (Medicaid data)

A general measure of how commonly Fluconazole is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Fluconazole is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

3,462,620
Medicaid prescriptions filled (Q1–Q4 2025)
$31.4M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Fluconazole prescribed? Of the 1,601 medications we measure, Fluconazole ranks #58 by Medicaid prescriptions — more than 96% of them.

Where Fluconazole ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #58 of 1,601
#53 Lisdexamfetamine 3,941,773 Rx #54 Cephalexin 3,933,834 Rx #55 Rosuvastatin 3,856,155 Rx #56 Insulin Glargine (rDNA... 3,731,821 Rx #57 Clonazepam 3,602,972 Rx #58 Fluconazole 3,462,620 Rx #59 Polyethylene Glycol 33... 3,441,581 Rx #60 Doxycycline 3,416,939 Rx #61 Risperidone 3,411,596 Rx #62 Lidocaine 3,379,243 Rx #63 Budesonide / Formotero... 3,326,951 Rx

Utilization by Fluconazole product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 150 mg oral tablet is the most-dispensed Fluconazole product — about 84% of these Medicaid prescriptions.

fluconazole 150 MG Oral Tablet Most dispensed

2,910,267 Medicaid prescriptions (Q1–Q4 2025) 84% of Fluconazole prescriptions shown $23.4M gross reimbursement (before rebates) ≈ $8.04 per prescription (gross)

Summed across the 10 of 159 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197699

fluconazole 200 MG Oral Tablet

268,824 Medicaid prescriptions (Q1–Q4 2025) 8% of Fluconazole prescriptions shown $3.7M gross reimbursement (before rebates) ≈ $14 per prescription (gross)

Summed across the 14 of 206 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197700

fluconazole 100 MG Oral Tablet

187,577 Medicaid prescriptions (Q1–Q4 2025) 5% of Fluconazole prescriptions shown $1.8M gross reimbursement (before rebates) ≈ $9.81 per prescription (gross)

Summed across the 13 of 163 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197698

fluconazole 40 MG/ML Oral Suspension

51,577 Medicaid prescriptions (Q1–Q4 2025) 1% of Fluconazole prescriptions shown $1.6M gross reimbursement (before rebates) ≈ $31 per prescription (gross)

Summed across the 4 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 310353

fluconazole 10 MG/ML Oral Suspension

41,886 Medicaid prescriptions (Q1–Q4 2025) 1% of Fluconazole prescriptions shown $807,673 gross reimbursement (before rebates) ≈ $19 per prescription (gross)

Summed across the 3 of 6 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 310352

fluconazole 50 MG Oral Tablet

1,761 Medicaid prescriptions (Q1–Q4 2025) <1% of Fluconazole prescriptions shown $19,436 gross reimbursement (before rebates) ≈ $11 per prescription (gross)

Summed across the 6 of 71 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197701

200 ML fluconazole 2 MG/ML Injection

438 Medicaid prescriptions (Q1–Q4 2025) <1% of Fluconazole prescriptions shown $18,537 gross reimbursement (before rebates) ≈ $42 per prescription (gross)

Summed across the 3 of 16 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1721314

100 ML fluconazole 2 MG/ML Injection

290 Medicaid prescriptions (Q1–Q4 2025) <1% of Fluconazole prescriptions shown $5,231 gross reimbursement (before rebates) ≈ $18 per prescription (gross)

Summed across the 2 of 18 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1721315

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Fluconazole, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 55 of 648 listed Fluconazole NDCs with Medicaid activity.

Compare Fluconazole products

A representative set of FDA-listed product records for Fluconazole — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 200 of 528 products — FDA National Drug Code Directory. See every product, package size and price: browse all 528 Fluconazole NDCs →

Fluconazole recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list no Fluconazole recalls since July 2021.

✅No Fluconazole recalls on record since July 2021

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Fluconazole RxCUI 4450 4 dose forms · 13 strengths
  2. Dose form (SCDF) Oral Capsule RxCUI 372208 No current FDA listing
    Clinical drug / strength (SCD) 50 MG RxCUI 199747 100 MG RxCUI 199950 150 MG RxCUI 199745 200 MG RxCUI 199746
  3. Dose form (SCDF) Oral Suspension RxCUI 372209 In current FDA listings
    Clinical drug / strength (SCD) 10 MG/ML RxCUI 310352 40 MG/ML RxCUI 310353
  4. Dose form (SCDF) Oral Tablet RxCUI 372210 In current FDA listings
    Clinical drug / strength (SCD) 50 MG RxCUI 197701 100 MG RxCUI 197698 150 MG RxCUI 197699 200 MG RxCUI 197700

Look up RxCUI 4450 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

Fluconazole brand names

Fluconazole is sold under 2 brand names in the FDA directory — Diflucan, Fluconazole in Sodium Chloride. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Diflucan Fluconazole in Sodium Chloride

Who makes Fluconazole: manufacturers and labelers

81 companies list Fluconazole products with the FDA. By number of product records, the largest are Bryant Ranch Prepack, Remedyrepack Inc., A-S Medication Solutions. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Bryant Ranch Prepack 45 Remedyrepack Inc. 31 A-S Medication Solutions 25 NuCare Pharmaceuticals,Inc. 24 Aurobindo Pharma Limited 24 Golden State Medical Supply, Inc. 20 Proficient Rx LP 19 NorthStar Rx LLC 18 Hikma Pharmaceuticals USA Inc. 15 PD-Rx Pharmaceuticals, Inc. 14 Direct RX 13 Zydus Pharmaceuticals (USA) Inc. 12 Rising Pharma Holdings, Inc. 12 Preferred Pharmaceuticals Inc. 12 Greenstone LLC 12 Glenmark Pharmaceuticals Inc., USA 12 Dr. Reddy's Laboratories Limited 12 Roerig 12 BluePoint Laboratories 12 ANI Pharmaceuticals, Inc. 12 Sportpharm LLC 9 Zydus Lifesciences Limited 9 Chartwell RX, LLC 8 Drug Ocean LLC 8

…and 57 more on the FDA NDC directory.

Fluconazole drug class (RxNorm)

Fluconazole belongs to the Azole Antifungal class.

Pharmacologic class Azole Antifungal
Drug family (ATC) Imidazole and triazole derivatives, Triazole and tetrazole derivatives
How it works Cytochrome P450 2C19 Inhibitors, Cytochrome P450 3A4 Inhibitors, Cytochrome P450 2C9 Inhibitors

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Fluconazole page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

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FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Apr 2, 2026
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Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Fluconazole.
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Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
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Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Fluconazole after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
104
Finished products in the current FDA directory
528
Companies listing them (makers, repackagers, distributors)
81
Linked representative label ⓘ
Roerig
Linked label effective
Apr 2, 2026
Composite sections available
18
Linked SPL Set ID
f694c617-3383-416c-91b6-b94fda371204
Linked SPL Document ID
c835d7dd-af65-4b2c-a92c-42d1986f902d
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Roerig is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →