Rifampin
Rifampin is an antibiotic used to treat all forms of tuberculosis and to clear Neisseria meningitidis bacteria from the nose and throat of people who carry them without symptoms (meningococcal carriers).
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 11 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
Rifampin, around since about 1971 and available generically, is a cornerstone antibiotic for tuberculosis (always with other TB drugs) and also clears meningococcal bacteria from people who carry them without being sick, working by blocking an enzyme bacteria need to make their genetic messages. Most people tolerate it reasonably well beyond some stomach upset, and nearly everyone notices orange-red urine, sweat, saliva and tears, which is expected and harmless. Watch for liver injury, and report yellow skin or eyes, dark urine, rash, unusual bleeding or breathing trouble right away. It also weakens many other medicines, including hormonal birth control, so give every prescriber and pharmacist your full list.
Clinical pearls
- Take the capsules on an empty stomach, one hour before or two hours after a meal, with a full glass of water.
- Take rifampin at least one hour before any antacid, since antacids cut how much gets absorbed.
- Use a non-hormonal birth control method, such as condoms, for the whole course, since the pill may fail.
- Take it every day without gaps, since irregular dosing can bring on flu-like fever, chills and bone pain and invite resistance.
Patient information guide A plain-language walkthrough of Rifampin, written from its FDA label.
What Rifampin is used for
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Rifampin is an antibiotic used for these conditions:
- All forms of tuberculosis, as part of a multi-drug regimen (capsules and injection).
- Asymptomatic carriers of Neisseria meningitidis, to clear the bacteria from the nose and throat (capsules and Rifampin for Injection).
- Rifadin IV and Rifampin for Injection are used for initial treatment and retreatment of tuberculosis when the drug cannot be taken by mouth.
Rifampin is not used to treat an actual meningococcal infection.
How Rifampin works
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Rifampin blocks bacterial RNA polymerase, an enzyme bacteria need to make their genetic messages and survive. It does not block the human version of this enzyme. It kills slow-growing and intermittently growing tuberculosis bacteria.
Resistance can develop quickly, through a single change in this bacterial enzyme. That is why rifampin is used in combination for tuberculosis and why bacteria may be tested for susceptibility.
Rifampin dosage
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Rifampin capsules are taken by mouth, usually once daily for tuberculosis. Take them 1 hour before or 2 hours after a meal with a full glass of water. The injection is given by a healthcare professional as an IV infusion.
- Tuberculosis treatment usually starts with a multi-drug phase of about 2 months, then continues with rifampin and isoniazid for at least 4 months. It may be longer in some cases.
- For meningococcal carriers, the course is short, about two days.
Follow your prescriber's directions and the label on your prescription.
Dosing details from the FDA-approved label
From the Rifampin prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.
- Tuberculosis - Adults
- 10 mg/kg, in a single daily administration, oral or IV
- Oral rifampin once daily, either 1 hour before or 2 hours after a meal with a full glass of water
- Maximum: 600 mg/day
- See CLINICAL PHARMACOLOGY for dosing in patients with renal failure
- Tuberculosis - Pediatric Patients
- 10-20 mg/kg, oral or IV
- Maximum: 600 mg/day
- See CLINICAL PHARMACOLOGY for dosing in patients with renal failure
- Meningococcal Carriers - Adults
- 600 mg rifampin administered twice daily for two days
- Meningococcal Carriers - Pediatric patients 1 month of age or older
- 10 mg/kg every 12 hours for two days
- Maximum: 600 mg per dose
- Meningococcal Carriers - Pediatric patients under 1 month of age
- 5 mg/kg every 12 hours for two days
Read the label’s full dosing text
DOSAGE AND ADMINISTRATION Rifampin can be administered by the oral route (see INDICATIONS AND USAGE ). See CLINICAL PHARMACOLOGY for dosing information in patients with renal failure. Tuberculosis Adults 10 mg/kg, in a single daily administration, not to exceed 600 mg/day, orally. Pediatric Patients 10 to 20 mg/kg, not to exceed 600 mg/day, orally. It is recommended that oral rifampin be administered once daily, either 1 hour before or 2 hours after a meal with a full glass of water. Rifampin is indicated in the treatment of all forms of tuberculosis. A three-drug regimen consisting of rifampin, isoniazid, and pyrazinamide is recommended in the initial phase of short-course therapy which is usually continued for 2 months. The Advisory Council for the Elimination of Tuberculosis, the American Thoracic Society, and the Centers for Disease Control and Prevention recommend that either streptomycin or ethambutol be added as a fourth drug in a regimen containing isoniazid (INH), rifampin, and pyrazinamide for initial treatment of tuberculosis unless the likelihood of INH resistance is very low. The need for a fourth drug should be reassessed when the results of susceptibility testing are known. If community rates of INH resistance are currently less than 4%, an initial treatment regimen with less than four drugs may be considered. Following the initial phase, treatment should be continued with rifampin and isoniazid for at least 4 months. Treatment should be continued for longer if the patient is still sputum or culture positive, if resistant organisms are present, or if the patient is HIV positive. Meningococcal Carriers Adults For adults, it is recommended that 600 mg rifampin be administered twice daily for two days. Pediatric Patients Pediatric patients 1 month of age or older: 10 mg/kg (not to exceed 600 mg per dose) every 12 hours for two days. Pediatric Patients Under 1 Month of Age 5 mg/kg every 12 hours for two days. Preparation of Extemporaneous Oral Suspension For pediatric and adult patients in whom capsule swallowing is difficult or where lower doses are needed, a liquid suspension may be prepared as follows: Rifampin 1% w/v suspension (10 mg/mL) can be compounded using one of four syrups-Simple Syrup (Syrup NF), Simple Syrup (Humco Laboratories), SyrPalta® Syrup (Emerson Laboratories), or Raspberry Syrup (Humco Laboratories). 1.
Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →
Rifampin side effects
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Many people have mild effects, mostly stomach-related.
Common side effects
- Heartburn or upset stomach
- Nausea, vomiting or loss of appetite
- Gas, cramps or diarrhea
- Headache, drowsiness or fatigue
- Dizziness
- Flushing and itching, with or without a rash
- Orange-red color of urine, sweat, saliva and tears
- Tooth discoloration, which may be permanent
When to get medical help
- Yellowing of the skin or eyes, dark urine, or severe stomach pain, which can be signs of liver injury
- Fever, rash, hives, swelling of the face or lips, or trouble breathing, which can be signs of an allergic reaction
- Blistering, peeling or widespread skin rash, or mouth sores, which can be signs of a severe skin reaction
- Unusual bleeding or bruising, or purple spots on the skin
- Cough, shortness of breath or breathing trouble, which can be signs of lung problems
- Diarrhea that is severe or does not go away
- Flu-like symptoms such as fever, chills, headache and bone pain, especially if you take the medicine irregularly
- Unexplained low platelets or anemia, which can be a sign of a blood clotting problem called thrombotic microangiopathy
Rifampin warnings and precautions
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- Liver injury can be severe, especially with liver disease or other liver-toxic drugs.
- Serious allergic and skin reactions can occur. Stop and call your doctor if they appear.
- Bleeding problems from low vitamin K–dependent clotting factors can occur. Clotting tests may be needed.
- Lung toxicity can be fatal in rare cases.
- A clotting and blood disorder called thrombotic microangiopathy has been reported.
- Paradoxical drug reaction means symptoms can seem to worsen even though treatment is working. Tell your doctor if this happens.
- Rifampin can worsen porphyria.
Rifampin interactions
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Rifampin speeds up how the body breaks down many medicines, so they may stop working as well.
- Hormonal birth control: less effective. Use a non-hormonal method.
- Certain HIV medicines, praziquantel and lurasidone: must not be combined.
- Warfarin: blood clotting tests are needed.
- Isoniazid and halothane: higher risk of liver injury.
- Cefazolin: risk of serious bleeding.
- Antacids: take rifampin at least 1 hour before.
- Digoxin, tacrolimus, methadone and diabetes medicines: may need dose changes.
Interactions listed in the FDA-approved label
From the Rifampin prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.
- Saquinavir/ritonavir (ritonavir-boosted saquinavir): Healthy subjects given rifampin with saquinavir 1000 mg/ritonavir 100 mg twice daily developed severe hepatocellular toxicity; saquinavir AUC decreased by 70%. Concomitant use is contraindicated
- Halothane or isoniazid (other hepatotoxic medications): The potential for hepatotoxicity is increased when given with rifampin. Avoid concomitant use of rifampin and halothane; monitor patients receiving rifampin and isoniazid closely for hepatotoxicity
- Atazanavir, darunavir, tipranavir, fosamprenavir, cabotegravir, fostemsavir, lenacapavir (SUNLENCA): Rifampin decreases exposure (e.g., atazanavir AUC by 72%, fosamprenavir by 82%, cabotegravir by 59%, fostemsavir by 82%, lenacapavir by 84%), which may result in loss of therapeutic effect and development of resistance. Concomitant use is contraindicated
- Zidovudine, indinavir, efavirenz: Rifampin decreases AUC (zidovudine by 47%, indinavir by 92%, efavirenz by 26%). Avoid concomitant use
- Systemic hormonal contraceptives (estrogens, progestins): Rifampin decreases exposure. Advise patients to change to non-hormonal methods of birth control during rifampin therapy
- Oral anticoagulants (warfarin): Rifampin decreases warfarin exposure. Perform prothrombin time daily or as frequently as necessary to establish and maintain the required dose of anticoagulant
- Digoxin: Rifampin decreases digoxin exposure. Measure serum digoxin concentrations before initiating rifampin. Continue monitoring and increase digoxin dose by approximately 20%-40% as necessary.
- Praziquantel: Decreases plasma praziquantel concentrations to undetectable levels. Concomitant use is contraindicated
- Antacids: Concomitant antacid administration may reduce the absorption of rifampin. Give daily doses of rifampin at least 1 hour before the ingestion of antacids
- Atovaquone: Decreases concentrations of atovaquone and increases concentrations of rifampin, which may increase the risk of rifampin toxicities. Coadministration is not recommended
Read the label’s full interactions text
DRUG INTERACTIONS Pharmacodynamic Interactions Healthy subjects who received rifampin 600 mg once daily concomitantly with saquinavir 1000 mg/ritonavir 100 mg twice daily (ritonavir-boosted saquinavir) developed severe hepatocellular toxicity. Therefore, concomitant use of these medications is contraindicated. (See CONTRAINDICATIONS.) When rifampin is given concomitantly with other hepatotoxic medications such as halothane or isoniazid, the potential for hepatotoxicity is increased. The concomitant use of rifampin and halothane should be avoided. Patients receiving both rifampin and isoniazid should be monitored closely for hepatotoxicity. Effect of Rifampin on Other Drugs Induction of Drug Metabolizing Enzymes and Transporters Drug metabolizing enzymes and transporters affected by rifampin include cytochromes P450 (CYP) 1A2, 2B6, 2C8, 2C9, 2C19, and 3A4, UDP-glucuronyltransferases (UGT), sulfotransferases, carboxylesterases, and transporters including P-glycoprotein (P-gp) and multidrug resistance-associated protein 2 (MRP2). Most drugs are substrates for one or more of these enzyme or transporter pathways and these pathways may be induced by rifampin simultaneously. Therefore, rifampin may increase the metabolism and decrease the activity of certain coadministered drugs or increase the activity of a coadministered pro-drug (where metabolic activation is required), and has the potential to perpetuate clinically important drug-drug interactions against many drugs and across many drug classes (Table 1). Table 1 summarizes the effect of rifampin on other drugs or drug classes. Adjust dosages of concomitant drugs based on approved drug labeling and if applicable, therapeutic drug monitoring, unless otherwise specified.
Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →
Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.
Before taking Rifampin
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- Do not take rifampin if you are allergic to rifampin or other rifamycins.
- Tell your prescriber about liver disease, alcohol use, porphyria, bleeding problems or poor nutrition.
- Rifampin capsules must not be taken with the contraindicated medicines listed above.
- Kidney problems can raise rifampin levels after higher doses. Your prescriber will decide if any changes are needed.
- Children may take rifampin at doses based on body weight, as directed by their prescriber.
Rifampin overdose
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Too much rifampin can cause nausea, vomiting, stomach pain, itching, headache and increasing sleepiness. It turns the skin, urine, sweat, saliva, tears and stool a brownish-red or orange color. Liver swelling, jaundice and serious heart rhythm problems or seizures have been reported in severe cases. Get emergency help right away if an overdose is suspected.
What Rifampin does in the body
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Rifampin kills slow-growing and intermittently growing tuberculosis bacteria by blocking their RNA polymerase. It is also active against Neisseria meningitidis. Bacteria can become resistant quickly, so combination treatment and susceptibility testing matter.
How your body processes Rifampin
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Rifampin is readily absorbed from the gut, but food lowers absorption by about 30%. It spreads widely through the body, including into spinal fluid. It is cleared mostly through bile, with up to 30% passing out in urine. Its half-life is about 3 hours after a first dose and shortens to about 2 to 3 hours with repeated doses.
How to store Rifampin
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Store at 20º to 25º C (68º to 77º F) Dispense contents in a tight light-resistant container as defined in the USP with a child resistant closure, as required. Store in a dry place. Avoid excessive heat.
Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
Supplements & herbs that interact with Rifampin
222 supplements and herbal products have documented interactions with Rifampin in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.
- Major · 9
- Moderate · 172
- Minor · 41
Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.
Nutrient depletion considerations
Rifampin has been associated with lower levels of 8 nutrients in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.
- Higher significance · 6
- Moderate · 2
Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.
Rifampin: pharmacist answers to common questions
Quick, plain-English answers to the questions patients ask most about Rifampin — the kind of thing our pharmacy team would talk through with you at the counter.
What is rifampin for?
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How should I take my capsules?
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Why is my urine orange?
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Can I still use my birth control?
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What side effects should make me call my doctor?
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Do I need to tell my doctor about my other medicines?
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Is Rifampin available over the counter?
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When was Rifampin first available?
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Who makes Rifampin?
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Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
More about Rifampin on HelloPharmacist
Rifampin forms and strengths (how it comes)
Rifampin is available in 2 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Capsule
How this form is used
- Rifampin capsules are used for all forms of tuberculosis.
- Rifampin capsules are used for asymptomatic carriers of Neisseria meningitidis.
- Rifampin capsules are taken by mouth, once daily for tuberculosis, 1 hour before or 2 hours after a meal with a full glass of water.
- Rifampin capsules for meningococcal carriers are taken for a short course of two days.
- For people who have trouble swallowing capsules, the Rifampin label describes a liquid suspension that a pharmacist can prepare from the capsules.
Injection
How this form is used
- Rifadin IV is used for initial treatment and retreatment of tuberculosis when the drug cannot be taken by mouth.
- Rifampin for Injection is used for initial treatment and retreatment of tuberculosis when the drug cannot be taken by mouth.
- Rifampin for Injection is also used for asymptomatic meningococcal carriers.
- Rifampin for Injection is given by IV infusion only.
- Rifadin IV can be given by mouth or by IV infusion according to its label.
- Rifampin for Injection powder is mixed with sterile water and then diluted in an infusion solution by a healthcare professional before use.
Rifampin on the U.S. market: products, makers and brands
How Rifampin appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
14 companies list 20 Rifampin product records with the FDA, mostly as capsule, injection; the earliest marketing or approval year on record is 1971. Brand names on the directory include Rimactane, Rifadin IV; the rest are generics.
FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
Also listed with the FDA, not a patient dose form: Powder (12) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
How widely Rifampin is used (Medicaid data)
A general measure of how commonly Rifampin is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Rifampin is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Rifampin prescribed? Of the 1,601 medications we measure, Rifampin ranks #551 by Medicaid prescriptions — more than 66% of them.
Utilization by Rifampin product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
rifampin 300 MG Oral Capsule Most dispensed
Summed across the 7 of 61 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 198202
rifampin 150 MG Oral Capsule
Summed across the 2 of 17 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 198201
rifampin 600 MG Injection
Summed across the 2 of 7 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 312821
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Rifampin, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 11 of 85 listed Rifampin NDCs with Medicaid activity.
Compare Rifampin products
A representative set of FDA-listed product records for Rifampin — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Capsule | ||||
| 300 mg | Oral | A-S Medication Solutions | ANDA | View NDC → |
| 150 mg | Oral | American Health Packaging | ANDA | View NDC → |
| 300 mg | Oral | American Health Packaging | ANDA | View NDC → |
| 150 mg | Oral | ANI Pharmaceuticals, Inc. | ANDA | View NDC → |
| 300 mg | Oral | ANI Pharmaceuticals, Inc. | ANDA | View NDC → |
| 300 mg | Oral | Bryant Ranch Prepack | ANDA | View NDC → |
| 150 mg | Oral | Chartwell RX, LLC | ANDA | View NDC → |
| 300 mg | Oral | Chartwell RX, LLC | ANDA | View NDC → |
| 150 mg | Oral | Coupler LLC | ANDA | View NDC → |
| 150 mg | Oral | Epic Pharma, Llc | ANDA | View NDC → |
| 300 mg | Oral | Epic Pharma, Llc | ANDA | View NDC → |
| 150 mg | Oral | Lupin Pharmaceuticals, Inc. | ANDA | View NDC → |
| 300 mg | Oral | Lupin Pharmaceuticals, Inc. | ANDA | View NDC → |
| 300 mg | Oral | Major Pharmaceuticals | ANDA | View NDC → |
| 150 mg | Oral | Puracap Laboratories Llc Dba Blu Pharmaceuticals | ANDA | View NDC → |
| 300 mg | Oral | Puracap Laboratories Llc Dba Blu Pharmaceuticals | ANDA | View NDC → |
| 💊Injection | ||||
| 600 mg | Intravenous | Fresenius Kabi USA, LLC | ANDA | View NDC → |
| 600 mg | Intravenous | Hikma Pharmaceuticals USA Inc. | ANDA | View NDC → |
| 600 mg/10 mL | Intravenous | Mylan Institutional LLC | ANDA | View NDC → |
| 600 mg/10 mL | Intravenous | Sanofi-Aventis U.S. LLC | NDA | View NDC → |
Showing 20 of 20 products — FDA National Drug Code Directory. See every product, package size and price: browse all 20 Rifampin NDCs →
Rifampin side effects reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Rifampin — a signal of what to watch for, not proof the drug caused it.
The effects most often named in FDA reports that mention Rifampin are drug interaction, drug reaction with eosinophilia and systemic symptoms, nausea; about 83% of the reports were classed as serious. These are voluntary reports, so they show what people report, not how often it happens.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Rifampin in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
Rifampin FDA approval history
How Rifampin went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Rifampin was first approved by the FDA in 1971 (Brand: RIFADIN · Sanofi Aventis Us); the first generic version was approved in 1975. It remains available in U.S. pharmacies today.
Source: Drugs@FDA.
Rifampin recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
The FDA’s enforcement reports list 6 Rifampin recalls since July 2021, covering 7 product listings. None of them is still listed as ongoing. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.
- Rifampin Capsules USP, 150 mg, 30 Capsules (3 x 10) unit doses per carton, Rx Only, Distributed by: American Health Packaging, Columbus, Ohio 43217. NDC Carton: 60687-575-21; NDC Unit Dose: 60687-575… Lots: Lot #: 1008111, Exp. Date 01/31/2024 FDA record D-0285-2024 →
- Rifampin Capsules USP 300mg, 30-count bottle, Rx Only, Manufactured for: Lupin Pharmaceuticals, Inc. Baltimore, Maryland 21202 United States, Manufactured Lupin Limited, Aurangabad 431 210 INDIA, NDC… Lots: A200817 exp 1/2024 FDA record D-0284-2024 →
- Rifampin Capsules USP 150mg, 30-count bottle, Rx Only, Manufactured for: Lupin Pharmaceuticals, Inc. Baltimore, Maryland 21202 United States, Manufactured Lupin Limited, Aurangabad 431 210 INDIA, NDC… Lots: A200816 exp 1/2024 A201248 exp 3/2024 FDA record D-0283-2024 →
- Rifampin Capsules USP, 300 mg, 100 Capsules (10 x 10) per carton, Rx Only, Distributed by: American Health Packaging, Columbus, Ohio 43217, Carton NDC 60687-586-01 (Individual Dose NDC: 60687-586-11) Lots: Lot #: 1007805, exp. 12/31/2023 FDA record D-0165-2023 →
- Rifampin Capsules USP, 300 mg, 30-count bottle; Rx Only, Manufactured for: Lupin Pharmaceuticals Baltimore, Maryland 21202, Manufactured by: Lupin Limited Aurangabad 431 210 India. NDC 68180-659-06 Lots: Lot # A200171, Exp 12/2023 FDA record D-0100-2023 →
- Rifampin Capsules, USP, 150 mg, 30 count HDPE bottles, Rx Only, Manufactured for Lupin Pharmaceuticals, Inc., Baltimore, MD, 21202 NDC: 68180-658-06 Lots: Lot #A200170, exp. date December 2023 FDA record D-1343-2022 →
- Rifampin for Injection, USP, 600 mg/vial, One Vial per carton, Rx only, Manufactured for: Mylan Institutional LLC, Morgantown, WV 26505 U.S.A., NDC 67457-445-60 Lots: Lot #: 7008990, exp. date Dec-2022; 7009025, exp. date Feb-2023; 7009085, 7009086, exp. date Apr-2023 FDA record D-0774-2022 →
Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 9384 4 dose forms · 6 strengths
-
Dose form (SCDF) Injection RxCUI 1863365In current FDA listingsClinical drug / strength (SCD) 600 MGRxCUI 312821 -
Dose form (SCDF) Oral Capsule RxCUI 373781In current FDA listings -
Dose form (SCDF) Oral Suspension RxCUI 376647No current FDA listingClinical drug / strength (SCD) 20 MG/MLRxCUI 246297 -
Dose form (SCDF) Oral Tablet RxCUI 373783No current FDA listingClinical drug / strength (SCD) 150 MGRxCUI 433775450 MGRxCUI 199802
Look up RxCUI 9384 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
Rifampin supply and shortage status
Whether Rifampin is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Rifampin is currently listed in shortage by the FDA (10 presentations on record).
⚠️Currently in shortage (FDA) — RifampinSource: openFDA, from the FDA Drug Shortages database.
💵 What Rifampin costs pharmacies (NADAC benchmark)
The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.
| Form | Strength | Pharmacy acquisition benchmark | |
|---|---|---|---|
| Capsule · Oral | 300 mg | $0.679 per capsule | NDC details & price history |
| Capsule · Oral | 150 mg | $0.898 per capsule | NDC details & price history |
Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.
Rifampin brand names
Rifampin is sold under 2 brand names in the FDA directory — Rimactane, Rifadin IV. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.
Who makes Rifampin: manufacturers and labelers
14 companies list Rifampin products with the FDA. By number of product records, the largest are ANI Pharmaceuticals, Inc., American Health Packaging, Chartwell RX, LLC. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.
Rifampin drug class (RxNorm)
Rifampin belongs to the Rifamycin Antibacterial class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
Sources for this Rifampin page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How this page is built
HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. ANI Pharmaceuticals, Inc. is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →