FDA-filed SPL labeling · retrieved through openFDA

Doxycycline

Doxycycline is a broad-spectrum antibiotic used to treat a wide range of bacterial infections, from respiratory and sexually transmitted infections to anthrax and malaria prevention.

Brand names ActiclateDoryx MpcDoryxMonodoxOracea +11 more
Drug class ⓘ Tetracycline-class Drug
Rx Forms 8 Routes Oral · Intravenous
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 251 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveApr 15, 2025
Clinical labels in scope ⓘ251
AvailabilityRx
Earliest approval/marketing year ⓘ1967
FDA-listed product records ⓘ969
Boxed warningNone found in compared labels
How we combine label and product data →
Other forms & routes:
Injection
⭐ Doxycycline at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Doxycycline is a well-established antibiotic that works against a wide range of infections — but it comes with important precautions, especially around pregnancy and young children. Take it exactly as directed, protect yourself from sun exposure, and don't skip doses. If you develop severe diarrhea, a bad skin reaction, or strong headaches with vision changes, reach out to your doctor right away.
How we write & review this content — our editorial policy →

📖 Doxycycline: Patient Information Guide

A plain-language walkthrough of Doxycycline — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

What Doxycycline is used for

▾

Doxycycline treats many types of bacterial infections. Here are the main categories:

  • Tick-borne and rickettsial infections — Rocky Mountain spotted fever, typhus, Q fever, tick fevers
  • Sexually transmitted infections (STIs) — chlamydia, gonorrhea, lymphogranuloma venereum, chancroid, granuloma inguinale, nongonococcal urethritis
  • Respiratory tract infections — including infections caused by Mycoplasma pneumoniae, Haemophilus influenzae, and others
  • Eye (ophthalmic) infections
  • Anthrax — including post-exposure prevention of inhalational anthrax
  • Malaria prevention (prophylaxis)
  • Adjunctive (add-on) treatment for severe acne and acute intestinal amebiasis
  • Alternative antibiotic when penicillin cannot be used

How Doxycycline works

▾

Doxycycline is a tetracycline-class antibiotic. It works by stopping bacteria from making the proteins they need to survive and multiply. Without those proteins, bacteria can't grow — and your immune system can clear the infection. It's described as bacteriostatic, meaning it halts bacterial growth rather than directly killing bacteria outright.

Because of how it works, doxycycline can lose effectiveness if bacteria develop resistance to it. That's why it should only be used when an infection is confirmed or strongly suspected to be bacterial — not for viral illnesses like the cold or flu.

How Doxycycline is taken (dosage)

▾

Doxycycline delayed-release tablets are taken by mouth, typically once or twice daily. The first day of treatment often involves a higher starting dose, followed by a lower maintenance dose — your prescriber will set the exact schedule. These tablets must be swallowed whole (never chewed or crushed), and taken with plenty of water.

  • If stomach upset occurs, taking with food or milk can help
  • The 200 mg tablet can be taken with or without food; food may actually reduce nausea
  • Tablets may also be sprinkled over applesauce if needed
  • This formulation is not interchangeable with other doxycycline products on a milligram-for-milligram basis — always use the form and schedule your prescriber specified

Doxycycline side effects in detail

▾

Most people tolerate doxycycline well, but here are the most commonly reported side effects:

  • Nausea and vomiting
  • Diarrhea
  • Headache
  • Upper abdominal pain
  • Vaginal yeast infection or bacterial vaginitis
  • Loss of appetite
  • Skin rash or increased sunburn sensitivity

More serious reactions — including severe skin blistering or peeling (like Stevens-Johnson syndrome), severe diarrhea from C. difficile, and increased pressure in the skull — are rare but require immediate medical attention.

Doxycycline warnings and precautions

▾
  • Teeth and bones in children: Doxycycline can permanently stain teeth yellow-gray-brown and slow bone growth in children under 8 and in developing fetuses. Avoid in this age group unless the infection is life-threatening with no alternative.
  • C. difficile gut infection: Antibiotics can disrupt normal gut bacteria, allowing C. difficile to overgrow. This can cause severe diarrhea or colitis — even weeks after finishing the antibiotic. Tell your doctor about any significant diarrhea.
  • Sun sensitivity (photosensitivity): Your skin may burn much more easily. Minimize sun exposure and avoid tanning beds while on doxycycline.
  • Increased pressure in the skull (pseudotumor cerebri): Headache, blurred vision, or double vision can be signs of this rare but serious condition. Stop the medication and seek care immediately.
  • Severe skin reactions: Conditions like Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported. Any widespread blistering or peeling of skin needs urgent medical evaluation.
  • Autoimmune reactions: Tetracyclines have been linked to autoimmune-type symptoms. If you develop joint pain, rash, or fever, contact your doctor promptly.

Doxycycline interactions: what it interacts with

▾

Doxycycline interacts with several common medications and products. Tell your doctor and pharmacist about everything you take:

  • Antacids (with aluminum, calcium, or magnesium): Block the antibiotic's absorption — take doxycycline at a different time
  • Iron supplements: Also reduce absorption — separate by several hours
  • Bismuth subsalicylate (Pepto-Bismol): Impairs how much doxycycline gets into your bloodstream
  • Blood thinners (anticoagulants like warfarin): Doxycycline can enhance their effect, raising bleeding risk — may need dose adjustment
  • Seizure medications (phenytoin, carbamazepine, barbiturates): Speed up doxycycline's breakdown, making it less effective
  • Oral contraceptives (birth control pills): May become less reliable — consider a backup method
  • Penicillin antibiotics: May not work as well when combined with doxycycline

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

Before taking Doxycycline

▾
  • Tetracycline allergy: Do not take doxycycline if you've had a reaction to any tetracycline antibiotic
  • Pregnancy: Can harm fetal bone and tooth development — discuss the risks and benefits carefully with your doctor
  • Breastfeeding: Doxycycline passes into breast milk; avoid if possible and discuss alternatives with your provider
  • Children under 8: Only use in life-threatening situations — permanent tooth discoloration and bone effects are a real concern
  • Kidney problems: Doxycycline can accumulate and potentially strain the liver if kidney function is severely impaired — your doctor may need to adjust your dose
  • Current medications: Especially important to flag blood thinners, seizure medications, antacids, and hormonal contraceptives

Doxycycline overdose: if you take too much

▾

If too much doxycycline is taken, stop the medication and seek medical care right away. Treatment focuses on managing symptoms and providing supportive care. Dialysis does not help clear doxycycline from the body and is not used for overdose.

Pharmacokinetics: how your body processes Doxycycline

▾

Doxycycline is absorbed almost completely after being taken by mouth — food can slightly reduce the peak level in your blood, but for the 200 mg tablet, overall absorption isn't significantly affected. It reaches peak blood levels within about 2–3 hours after a dose. The drug has a half-life (the time for half of it to leave your body) of roughly 16–22 hours, which supports once-daily dosing for many uses.

Doxycycline is concentrated by the liver and eliminated through both urine and feces. Even in people with severe kidney disease, the half-life stays about the same — so unlike many antibiotics, kidney impairment doesn't dramatically change how long it stays in the body. Hemodialysis does not remove it from the bloodstream.

How to store Doxycycline

▾

Store at 20° to 25°C (68° to 77°F) excursions permitted to 15° to 30°C (59° to 86°F) . Protect from light and moisture. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.

📄 Written from Doxycycline’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

166

Supplements & herbs that interact with Doxycycline

166 supplements and herbal products have documented interactions with Doxycycline in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 7
  • Moderate · 139
  • Minor · 20
ACTIVATED CHARCOAL Major ASARABACCA Major BEER Major OLEANDER Major SIBERIAN COCKLEBUR Major ST. JOHN'S WORT Major WINE Major ALFALFA Moderate +158 more
Every supplement checked against Doxycycline — ranked by severity The full interaction hub: 7 major · 139 moderate · 20 minor · every one linked to its full report. Check Doxycycline against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

7

Nutrient depletion considerations

Doxycycline has been associated with lower levels of 7 nutrients in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

Evidence & significance mix
  • Higher significance · 6
  • Moderate · 1
BIOTIN Insignificant Depletion FOLIC ACID Insignificant Depletion RIBOFLAVIN Insignificant Depletion THIAMINE Insignificant Depletion VITAMIN B12 Insignificant Depletion VITAMIN B6 Insignificant Depletion VITAMIN K Moderate Depletion
See the full Doxycycline nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

🩺 Doxycycline: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Doxycycline — the kind of thing our pharmacy team would talk through with you at the counter.

What kinds of infections does doxycycline actually treat?

▾
Doxycycline is quite versatile. It treats a wide range of bacterial infections — respiratory infections, STIs like chlamydia and gonorrhea, tick-borne illnesses like Rocky Mountain spotted fever, eye infections, and even anthrax. It's also used to prevent malaria and as a helper treatment for severe acne. The key word is 'bacterial' — it won't work against viral infections like the flu or common cold.

Should I take doxycycline with food or on an empty stomach?

▾
It depends on the tablet strength your doctor prescribed. In general, if doxycycline bothers your stomach, taking it with food or milk can help — and for the 200 mg tablet specifically, food doesn't meaningfully affect how well it's absorbed. Always take it with a full glass of water, swallow it whole (don't crush or chew), and stay upright for a bit after to protect your esophagus. Follow whatever instructions came with your prescription.

Can I take my antacid or iron supplement at the same time as doxycycline?

▾
Not at the same time, no. Antacids containing aluminum, calcium, or magnesium — and iron supplements — can significantly reduce how much doxycycline your body absorbs, making it less effective. Bismuth products like Pepto-Bismol have the same problem. Separate them by as much time as you can, and ask your pharmacist about the best timing for your specific schedule.

I'm on birth control pills — will doxycycline make them less effective?

▾
There is a known interaction: doxycycline may reduce the effectiveness of oral contraceptives. While the risk isn't enormous, it's worth discussing with your doctor or pharmacist. Using a backup method like condoms during your course of antibiotics is a reasonable precaution. Don't stop your birth control — just add a backup while you're on the antibiotic.

What side effects should I actually be worried about versus just ride out?

▾
Nausea, loose stools, and an upset stomach are pretty common and usually manageable — taking it with food often helps. Sun sensitivity is real, so protect your skin. The side effects that need immediate medical attention are: severe diarrhea that's watery or bloody (possible C. difficile infection), widespread skin blistering or peeling, a severe headache with blurred or double vision (possible pressure buildup in the skull), or signs of a serious allergic reaction. If anything feels 'off' and serious, don't wait — call your doctor.

Is doxycycline safe during pregnancy or for young children?

▾
This is one of the most important things to know. Doxycycline can permanently stain a child's teeth yellow-gray-brown and may slow bone growth — so it's generally avoided in children under 8 and during the second half of pregnancy, except in life-threatening situations where there's no safer option. If you're pregnant or breastfeeding, have an honest conversation with your doctor before taking it. The drug does pass into breast milk, so your provider may recommend an alternative if possible.

Is Doxycycline available over the counter?

▾
Doxycycline is dispensed by prescription according to its FDA labeling, so it isn't sold over the counter. Your prescriber and pharmacist will determine if it's appropriate for you.

When was Doxycycline first available?

▾
Doxycycline has been available in the United States since at least 1967, based on FDA approval history (Drugs@FDA) and product marketing records.

Who makes Doxycycline?

▾
Doxycycline is supplied by 141 manufacturers listed in the FDA NDC Directory, including Bryant Ranch Prepack, Remedyrepack Inc., A-S Medication Solutions.

💬 Answers drafted from Doxycycline’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 More about Doxycycline on HelloPharmacist

📊Doxycycline supplement interactions166 checked — ranked by severity 🌿Drug & Supplement CheckerDoxycycline vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Doxycycline NDCs & costs 🅰️Browse Drugs A–ZLook up any medication

💊 Doxycycline forms and strengths (how it comes)

Doxycycline is available in 8 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Capsule

By mouth
Brands Acticlate Oracea
Available strengths 5 strengths
40 mg 50 mg 75 mg 100 mg 150 mg
465 FDA-listed product records ⓘ

Tablet

By mouth
Brands Acticlate Targadox
Available strengths 5 strengths
20 mg 50 mg 75 mg 100 mg 150 mg
356 FDA-listed product records ⓘ

Delayed-release tablet

By mouth
Brands Doryx Doryx Mpc
Available strengths 8 strengths
50 mg 60 mg 75 mg 80 mg 100 mg 120 mg
Show 2 more strengths Show fewer strengths
150 mg 200 mg
70 FDA-listed product records ⓘ

Oral suspension

By mouth
Available strengths 2 strengths
25 mg/5 mL 1 kg/kg
13 FDA-listed product records ⓘ

Oral solution

By mouth
Available strengths 1 strength
50 mg/5 mL
2 FDA-listed product records ⓘ

Delayed-release capsule

By mouth
Available strengths 1 strength
40 mg
1 FDA-listed product record ⓘ

Topical cream, ointment or gel

By mouth
Available strengths 1 strength
2.5 g
1 FDA-listed product record ⓘ

📊 Doxycycline on the U.S. market: products, makers and brands

How Doxycycline appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

8
Dose forms ⓘ
141
Manufacturers
17
Brand names
969
FDA-listed product records ⓘ
1967
First marketed ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (18) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Bryant Ranch Prepack8%
Remedyrepack Inc.8%
A-S Medication Solutions8%
PD-Rx Pharmaceuticals, Inc.6%
NuCare Pharmaceuticals,Inc.5%
Alembic Pharmaceuticals Inc.4%
Other makers61%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Doxycycline is used (Medicaid data)

A general measure of how commonly Doxycycline is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Doxycycline is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

3,416,939
Medicaid prescriptions filled (Q1–Q4 2025)
$50.3M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Doxycycline prescribed? Of the 1,598 medications we measure, Doxycycline ranks #60 by Medicaid prescriptions — more than 96% of them.

Where Doxycycline ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #60 of 1,598
#55 Rosuvastatin 3,856,155 Rx #56 Insulin Glargine (rDNA... 3,731,821 Rx #57 Clonazepam 3,602,972 Rx #58 Fluconazole 3,462,620 Rx #59 Polyethylene Glycol 33... 3,441,581 Rx #60 Doxycycline 3,416,939 Rx #61 Risperidone 3,411,596 Rx #62 Lidocaine 3,379,243 Rx #63 Budesonide / Formotero... 3,326,951 Rx #64 Meloxicam 3,321,801 Rx #65 Folic Acid 3,298,551 Rx

Utilization by Doxycycline product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 100 mg oral capsule is the most-dispensed Doxycycline product — about 50% of these Medicaid prescriptions.

doxycycline hyclate 100 MG Oral Capsule Most dispensed

1,721,212 Medicaid prescriptions (Q1–Q4 2025) 50% of Doxycycline prescriptions shown $18.1M gross reimbursement (before rebates) ≈ $11 per prescription (gross)

Summed across the 16 of 332 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1649988

doxycycline hyclate 100 MG Oral Tablet

681,304 Medicaid prescriptions (Q1–Q4 2025) 20% of Doxycycline prescriptions shown $8.2M gross reimbursement (before rebates) ≈ $12 per prescription (gross)

Summed across the 25 of 342 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1650143

doxycycline monohydrate 100 MG Oral Capsule

569,572 Medicaid prescriptions (Q1–Q4 2025) 17% of Doxycycline prescriptions shown $7.3M gross reimbursement (before rebates) ≈ $13 per prescription (gross)

Summed across the 9 of 177 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1649990

doxycycline monohydrate 100 MG Oral Tablet

236,640 Medicaid prescriptions (Q1–Q4 2025) 7% of Doxycycline prescriptions shown $4.4M gross reimbursement (before rebates) ≈ $19 per prescription (gross)

Summed across the 6 of 46 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1650142

doxycycline hyclate 50 MG Oral Capsule

81,505 Medicaid prescriptions (Q1–Q4 2025) 2% of Doxycycline prescriptions shown $1.3M gross reimbursement (before rebates) ≈ $15 per prescription (gross)

Summed across the 6 of 79 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1649405

doxycycline monohydrate 50 MG Oral Capsule

32,531 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $441,962 gross reimbursement (before rebates) ≈ $14 per prescription (gross)

Summed across the 4 of 40 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1649401

doxycycline hyclate 20 MG Oral Tablet

28,975 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $449,486 gross reimbursement (before rebates) ≈ $16 per prescription (gross)

Summed across the 3 of 30 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 283535

doxycycline monohydrate 5 MG/ML Oral Suspension

27,690 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $1.4M gross reimbursement (before rebates) ≈ $52 per prescription (gross)

Summed across the 3 of 5 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1650030

doxycycline hyclate 50 MG Oral Tablet

13,140 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $4.4M gross reimbursement (before rebates) ≈ $336 per prescription (gross)

Summed across the 2 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1652674

doxycycline monohydrate 50 MG Oral Tablet

12,984 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $232,803 gross reimbursement (before rebates) ≈ $18 per prescription (gross)

Summed across the 3 of 13 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1652673

doxycycline hyclate 100 MG Injection

2,893 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $204,726 gross reimbursement (before rebates) ≈ $71 per prescription (gross)

Summed across the 11 of 43 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 310027

doxycycline anhydrous 40 MG Delayed Release Oral Capsule

2,750 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $1.2M gross reimbursement (before rebates) ≈ $442 per prescription (gross)

Summed across the 6 of 21 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 901399

doxycycline monohydrate 75 MG Oral Capsule

2,090 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $1.9M gross reimbursement (before rebates) ≈ $889 per prescription (gross)

Summed across the 1 of 30 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 700408

doxycycline hyclate 100 MG Delayed Release Oral Tablet

1,215 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $76,220 gross reimbursement (before rebates) ≈ $63 per prescription (gross)

Summed across the 2 of 11 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 434018

doxycycline monohydrate 75 MG Oral Tablet

648 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $16,673 gross reimbursement (before rebates) ≈ $26 per prescription (gross)

Summed across the 2 of 11 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1649429

doxycycline hyclate 60 MG Delayed Release Oral Tablet

589 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $618,493 gross reimbursement (before rebates) ≈ $1,050 per prescription (gross)

Summed across the 1 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1801142

doxycycline hyclate 75 MG Oral Tablet

493 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $15,688 gross reimbursement (before rebates) ≈ $32 per prescription (gross)

Summed across the 2 of 11 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1649425

doxycycline hyclate 150 MG Oral Tablet

342 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $13,145 gross reimbursement (before rebates) ≈ $38 per prescription (gross)

Summed across the 1 of 11 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1650446

doxycycline hyclate 200 MG Delayed Release Oral Tablet

289 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $23,193 gross reimbursement (before rebates) ≈ $80 per prescription (gross)

Summed across the 3 of 17 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1423080

doxycycline monohydrate 150 MG Oral Tablet

62 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $2,725 gross reimbursement (before rebates) ≈ $44 per prescription (gross)

Summed across the 1 of 17 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1650444

doxycycline hyclate 150 MG Delayed Release Oral Tablet

15 Medicaid prescriptions (Q1–Q4 2025) <1% of Doxycycline prescriptions shown $1,331 gross reimbursement (before rebates) ≈ $89 per prescription (gross)

Summed across the 1 of 19 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 799048

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Doxycycline, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 108 of 1,268 listed Doxycycline NDCs with Medicaid activity.

🔍 Compare Doxycycline products

A representative set of FDA-listed product records for Doxycycline — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 200 of 969 products — FDA National Drug Code Directory. See every product, package size and price: browse all 969 Doxycycline NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Doxycycline RxCUI 3640 8 dose forms · 32 strengths
  1. Dose form (SCDF) Delayed Release Oral Capsule RxCUI 378209 In current FDA listings
    Clinical drug / strength (SCD) anhydrous 40 MG RxCUI 901399 hyclate 100 MG RxCUI 348869
  3. Dose form (SCDF) Disintegrating Oral Tablet RxCUI 597519 In current FDA listings
    Clinical drug / strength (SCD) 75 MG RxCUI 597521
  4. Dose form (SCDF) Extended Release Oral Capsule RxCUI 578681 No current FDA listing
  5. Dose form (SCDF) Injection RxCUI 1652652 In current FDA listings
    Clinical drug / strength (SCD) hyclate 100 MG RxCUI 310027 hyclate 200 MG RxCUI 1998483
  7. Dose form (SCDF) Oral Suspension RxCUI 371964 In current FDA listings
    Clinical drug / strength (SCD) calcium 10 MG/ML RxCUI 310026 monohydrate 5 MG/ML RxCUI 1650030

Look up RxCUI 3640 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Doxycycline brand names

Acticlate Doryx Mpc Doryx Monodox Oracea Vibramycin Acticlate CAP Doxychel Periostat Vibra-Tabs Morgidox Mondoxyne Targadox Okebo Adoxa Doxy

🏭 Who makes Doxycycline: manufacturers and labelers

Bryant Ranch Prepack 62 Remedyrepack Inc. 61 A-S Medication Solutions 59 PD-Rx Pharmaceuticals, Inc. 42 NuCare Pharmaceuticals,Inc. 35 Alembic Pharmaceuticals Inc. 33 Zydus Pharmaceuticals USA Inc. 27 Proficient Rx LP 27 Alembic Pharmaceuticals Limited 27 Zydus Lifesciences Limited 25 Strides Pharma Science Limited 23 Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. 20 RedPharm Drug, Inc. 18 Sun Pharmaceutical Industries, Inc. 17 Chartwell RX LLC 16 Denton Pharma, Inc. DBA Northwind Pharmaceuticals 15 AvPAK 15 Chartwell Governmental & Specialty RX, LLC 15 American Health Packaging 14 Chartwell RX, LLC. 14 Mayne Pharma Commercial LLC 13 Amneal Pharmaceuticals NY LLC 12 Direct Rx 12 Chartwell RX, LLC 12

…and 16 more on the FDA NDC directory.

Doxycycline drug class (RxNorm)

Doxycycline belongs to the Tetracycline-class Drug class.

Pharmacologic class Tetracycline-class Drug
Drug family (ATC) Antiinfectives and antiseptics for local oral treatment, Tetracyclines

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Sources for this Doxycycline page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Apr 15, 2025
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Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Doxycycline.
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Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
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Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Doxycycline after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
251
NDC products indexed
969
Distinct labelers/manufacturers represented
141
Linked representative label ⓘ
Mayne Pharma Inc.
Linked label effective
Apr 15, 2025
Composite sections available
25
Linked SPL Set ID
0e6b3e17-aeee-4910-8e94-c7ac925b9cca
Linked SPL Document ID
4600dc6a-950d-4d84-aed9-da01fbd0db8b
Open the linked representative label on DailyMed ↗
NDC package records associated with this linked SPL 1

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 251 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Mayne Pharma Inc. is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.