Hydrochlorothiazide

Generic name: Pronounced as (hye'' droe klor'' oh thye' a zide)
Brand names
  • Esidrix®
  • Hydrodiuril®
  • Microzide®
  • Oretic®
  • Zide®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 02/15/2021

Hydrochlorothiazide is used alone or in combination with other medications to treat high blood pressure. Hydrochlorothiazide is used to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart, kidney, and liver disease and to treat edema caused by using certain medications including estrogen and corticosteroids. Hydrochlorothiazide is in a class of medications called diuretics ('water pills'). It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine.

High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

Hydrochlorothiazide comes as a tablet, capsule, and solution (liquid) to take by mouth. It usually is taken once or twice a day. When used to treat edema, hydrochlorothiazide may be taken daily or only on certain days of the week. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take hydrochlorothiazide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Hydrochlorothiazide controls high blood pressure but does not cure it. Continue to take hydrochlorothiazide even if you feel well. Do not stop taking hydrochlorothiazide without talking to your doctor.

Hydrochlorothiazide may also be used to treat patients with diabetes insipidus and to prevent kidney stones in patients with high levels of calcium in their blood. Talk to your doctor about the possible risks of using this medicine for your condition.

This medicine is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking hydrochlorothiazide,

  • tell your doctor and pharmacist if you are allergic to hydrochlorothiazide, 'sulfa drugs', penicillin, or any other drugs.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: barbiturates such as phenobarbital and secobarbital (Seconal); corticosteroids such as betamethasone (Celestone), budesonide (Entocort), cortisone (Cortone), dexamethasone (Decadron, Dexpak, Dexasone, others), fludrocortisone (Florinef), hydrocortisone (Cortef, Hydrocortone), methylprednisolone (Medrol, Meprolone, others), prednisolone (Prelone, others), prednisone (Deltasone, Meticorten, Sterapred, others), and triamcinolone (Aristocort, Azmacort); corticotropin (ACTH, H.P., Acthar Gel); insulin and oral medications for diabetes; lithium (Eskalith, Lithobid); medications for high blood pressure or pain; nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin, others) and naproxen (Aleve, Naprosyn, others). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • if you are taking cholestyramine or colestipol, take them 1 hour before or 4 hours after taking hydrochlorothiazide.

  • tell your doctor if you have kidney disease. Your doctor may tell you not to take hydrochlorothiazide.

  • tell your doctor if you have or have ever had diabetes, asthma, gout, systemic lupus erythematosus (SLE, a chronic inflammatory condition), high cholesterol, or kidney or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking hydrochlorothiazide, call your doctor immediately.

  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Hydrochlorothiazide may make your skin sensitive to sunlight and increase your risk of a certain types of skin cancer. Your doctor will check your skin for skin cancers during your treatment with hydrochlorothiazide. Call your doctor if you notice any new skin changes or growths.

  • you should know that hydrochlorothiazide may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking hydrochlorothiazide. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. Alcohol can add to these side effects.

If your doctor prescribes a low-salt or low-sodium diet, or to eat or drink increased amounts of potassium-rich foods (e.g., bananas, prunes, raisins, and orange juice) in your diet, follow these instructions carefully.

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Tell your doctor if any of these symptoms are severe or do not go away:

    • frequent urination

    • diarrhea

    • loss of appetite

    • headache

    • hair loss

  • If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment:

    • dry mouth; thirst; nausea; vomiting; weakness, tiredness; drowsiness; restlessness; confusion; muscle weakness, pain, or cramps; fast heartbeat and other signs of dehydration and electrolyte imbalance

    • blisters or peeling skin

    • hives

    • rash

    • itching

    • difficulty breathing or swallowing

    • fever, sore throat, chills, and other signs of infection

    • unusual bleeding or bruising

    • ongoing pain that begins in the stomach area, but may spread to the back

    • joint pain or swelling

    • changes in vision, eye pain, or swelling or redness in or around the eye

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medicine in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not allow the liquid or capsules to freeze.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your blood pressure should be checked regularly, and blood tests should be done occasionally.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking hydrochlorothiazide.

Do not let anyone else take your medicine. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Accuretic® (containing Quinapril, Hydrochlorothiazide)
  • Apresazide® (containing Hydralazine, Hydrochlorothiazide)
  • Benicar® HCT (containing Olmesartan, Hydrochlorothiazide)
  • Diovan® HCT (containing Valsartan, Hydrochlorothiazide)
  • Dutoprol® (containing Metoprolol, Hydrochlorothiazide)
  • Exforge® HCT (containing Amlodipine, Hydrochlorothiazide, Valsartan)
  • Hydra-Zide® (containing Hydralazine, Hydrochlorothiazide)
  • Hydrap-ES® (containing Hydralazine, Hydrochlorothiazide, Reserpine)
  • Hydro-Reserp® (containing Hydrochlorothiazide, Reserpine)
  • Hydropres® (containing Hydrochlorothiazide, Reserpine)
  • Hydroserp® (containing Hydrochlorothiazide, Reserpine)
  • Hydroserpine® (containing Hydrochlorothiazide, Reserpine)
  • Inderide® (containing Hydrochlorothiazide, Propranolol)
  • Inderide® LA (containing Hydrochlorothiazide, Propranolol)
  • Lopressor® HCT (containing Metoprolol, Hydrochlorothiazide)
  • Mallopress® (containing Hydrochlorothiazide, Reserpine)
  • Marpres® (containing Hydralazine, Hydrochlorothiazide, Reserpine)
  • Monopril® HCT (containing Fosinopril, Hydrochlorothiazide)
  • Normozide® (containing Labetalol, Hydrochlorothiazide)
  • Quinaretic® (containing Quinapril, Hydrochlorothiazide)
  • Ser-Ap-Es® (containing Hydralazine, Hydrochlorothiazide, Reserpine)
  • Serathide® (containing Hydralazine, Hydrochlorothiazide, Reserpine)
  • Serpazide® (containing Hydralazine, Hydrochlorothiazide, Reserpine)
  • Serpex® (containing Hydralazine, Hydrochlorothiazide, Reserpine)
  • Tekturna® HCT (containing Aliskiren, Hydrochlorothiazide)
  • Teveten® HCT (containing Eprosartan, Hydrochlorothiazide)
  • Timolide® (containing Timolol, Hydrochlorothiazide)
  • Trandate HCT® (containing Labetalol, Hydrochlorothiazide)
  • Tri-Hydroserpine® (containing Hydralazine, Hydrochlorothiazide, Reserpine)
  • Tribenzor® (containing Amlodipine, Hydrochlorothiazide, Olmesartan)
  • Uni Serp® (containing Hydralazine, Hydrochlorothiazide, Reserpine)
  • Unipres® (containing Hydralazine, Hydrochlorothiazide, Reserpine)
  • Ziac® (containing Bisoprolol, Hydrochlorothiazide)

Drug Interaction
Moxifloxacin Moxifloxacin The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Moxifloxacin.
Repaglinide Repaglinide The therapeutic efficacy of Repaglinide can be decreased when used in combination with Hydrochlorothiazide.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The therapeutic efficacy of Insulin glargine can be decreased when used in combination with Hydrochlorothiazide.
Dolasetron Dolasetron The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Dolasetron.
Alendronate Alendronate The risk or severity of nephrotoxicity and hypocalcemia can be increased when Hydrochlorothiazide is combined with Alendronic acid.
Anagrelide Anagrelide The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Anagrelide.
Bisacodyl Bisacodyl The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Bisacodyl.
Calcium Carbonate Calcium Carbonate Hydrochlorothiazide may decrease the excretion rate of Calcium carbonate which could result in a higher serum level.
Candesartan Candesartan The therapeutic efficacy of Candesartan can be increased when used in combination with Hydrochlorothiazide.
Cilostazol Cilostazol Hydrochlorothiazide may decrease the excretion rate of Cilostazol which could result in a higher serum level.
Diphenoxylate Diphenoxylate The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Diphenoxylate.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Hydrochlorothiazide may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate Fenofibrate The therapeutic efficacy of Fenofibrate can be decreased when used in combination with Hydrochlorothiazide.
Guanfacine Guanfacine The therapeutic efficacy of Guanfacine can be increased when used in combination with Hydrochlorothiazide.
Magnesium Hydroxide Magnesium Hydroxide Hydrochlorothiazide may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Magnesium Oxide Magnesium Oxide The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Magnesium oxide.
Methylergonovine Methylergonovine Methylergometrine may decrease the antihypertensive activities of Hydrochlorothiazide.
Miglitol Miglitol The therapeutic efficacy of Miglitol can be decreased when used in combination with Hydrochlorothiazide.
Mycophenolate Mycophenolate Hydrochlorothiazide may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Naratriptan Naratriptan Naratriptan may decrease the antihypertensive activities of Hydrochlorothiazide.
Olsalazine Olsalazine The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Olsalazine.
Paregoric Paregoric The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Morphine.
Penbutolol Penbutolol The therapeutic efficacy of Acebutolol can be increased when used in combination with Hydrochlorothiazide.
Pentazocine Pentazocine The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Pentazocine.
Polyethylene glycol-electrolyte solution (PEG-ES) Polyethylene glycol-electrolyte solution (PEG-ES) The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Polyethylene glycol.
Potassium Potassium Hydrochlorothiazide may decrease the excretion rate of Potassium cation which could result in a higher serum level.
Prednisone Prednisone The risk or severity of electrolyte imbalance can be increased when Prednisone is combined with Hydrochlorothiazide.
Psyllium Psyllium The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Plantago seed.
Ranitidine Ranitidine Hydrochlorothiazide may decrease the excretion rate of Ranitidine which could result in a higher serum level.
Rizatriptan Rizatriptan Hydrochlorothiazide may decrease the excretion rate of Rizatriptan which could result in a higher serum level.
Sumatriptan Sumatriptan Hydrochlorothiazide may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus Tacrolimus The risk or severity of nephrotoxicity can be increased when Tacrolimus is combined with Hydrochlorothiazide.
Tiludronate Tiludronate The risk or severity of nephrotoxicity and hypocalcemia can be increased when Hydrochlorothiazide is combined with Etidronic acid.
Tizanidine Tizanidine The risk or severity of QTc prolongation can be increased when Tizanidine is combined with Hydrochlorothiazide.
Triamcinolone Triamcinolone The risk or severity of electrolyte imbalance can be increased when Triamcinolone is combined with Hydrochlorothiazide.
Zolmitriptan Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Hydrochlorothiazide.
Ampicillin Injection Ampicillin Injection Hydrochlorothiazide may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Hydrochlorothiazide may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Famotidine Injection Famotidine Injection The excretion of Hydrochlorothiazide can be decreased when combined with Famotidine.
Fluconazole Injection Fluconazole Injection The serum concentration of Fluconazole can be increased when it is combined with Hydrochlorothiazide.
Foscarnet Injection Foscarnet Injection The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Foscarnet.
Hydromorphone Injection Hydromorphone Injection The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Hydromorphone.
Interferon Beta-1b Injection Interferon Beta-1b Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Interferon beta-1b.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Interferon gamma-1b.
Levofloxacin Injection Levofloxacin Injection The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Levofloxacin.
Meperidine Injection Meperidine Injection Hydrochlorothiazide may decrease the excretion rate of Meperidine which could result in a higher serum level.
Methylprednisolone Injection Methylprednisolone Injection The risk or severity of electrolyte imbalance can be increased when Methylprednisolone is combined with Hydrochlorothiazide.
Metoclopramide Injection Metoclopramide Injection Hydrochlorothiazide may decrease the excretion rate of Metoclopramide which could result in a higher serum level.
Metronidazole Injection Metronidazole Injection The risk or severity of QTc prolongation can be increased when Metronidazole is combined with Hydrochlorothiazide.
Morphine Injection Morphine Injection The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Morphine.
Pamidronate Injection Pamidronate Injection The risk or severity of nephrotoxicity can be increased when Pamidronic acid is combined with Hydrochlorothiazide.
Vancomycin Injection Vancomycin Injection Hydrochlorothiazide may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The excretion of Zidovudine can be decreased when combined with Hydrochlorothiazide.
Altretamine Altretamine Amphetamine may increase the hypotensive activities of Hydrochlorothiazide.
Cefuroxime Cefuroxime The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Cefuroxime.
Cyclosporine Cyclosporine The risk or severity of renal failure can be increased when Hydrochlorothiazide is combined with Cyclosporine.
Ondansetron Ondansetron The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Ondansetron.
Enoxaparin Injection Enoxaparin Injection The therapeutic efficacy of Enoxaparin can be decreased when used in combination with Hydrochlorothiazide.
Granisetron Granisetron The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Granisetron.
Torsemide Torsemide The therapeutic efficacy of Hydrochlorothiazide can be increased when used in combination with Torasemide.
Olanzapine Olanzapine The risk or severity of QTc prolongation can be increased when Olanzapine is combined with Hydrochlorothiazide.
Dofetilide Dofetilide The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Dofetilide.
Hydroxychloroquine Hydroxychloroquine The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Hydroxychloroquine.
Meloxicam Meloxicam The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Meloxicam.
Oxcarbazepine Oxcarbazepine The risk or severity of hyponatremia can be increased when Hydrochlorothiazide is combined with Oxcarbazepine.
Pantoprazole Pantoprazole Hydrochlorothiazide may decrease the excretion rate of Pantoprazole which could result in a higher serum level.
Risedronate Risedronate The risk or severity of nephrotoxicity and hypocalcemia can be increased when Hydrochlorothiazide is combined with Risedronic acid.
Sevelamer Sevelamer Sevelamer can cause a decrease in the absorption of Hydrochlorothiazide resulting in a reduced serum concentration and potentially a decrease in efficacy.
Temozolomide Temozolomide Hydrochlorothiazide may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon Zaleplon Hydrochlorothiazide may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Desloratadine Desloratadine The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Desloratadine.
Linezolid Linezolid Linezolid may increase the hypotensive activities of Hydrochlorothiazide.
Pentosan Polysulfate Pentosan Polysulfate The therapeutic efficacy of Pentosan polysulfate can be decreased when used in combination with Hydrochlorothiazide.
Trimipramine Trimipramine The risk or severity of QTc prolongation can be increased when Trimipramine is combined with Hydrochlorothiazide.
Glycopyrrolate Glycopyrrolate The serum concentration of Hydrochlorothiazide can be increased when it is combined with Glycopyrronium.
Perindopril Perindopril The therapeutic efficacy of Perindopril can be increased when used in combination with Hydrochlorothiazide.
Tenofovir Tenofovir Hydrochlorothiazide may increase the nephrotoxic activities of Tenofovir.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Choline magnesium trisalicylate.
Sirolimus Sirolimus The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Sirolimus.
Dutasteride Dutasteride Dutasteride may decrease the antihypertensive activities of Hydrochlorothiazide.
Epinephrine Injection Epinephrine Injection The risk or severity of Cardiac Arrhythmia can be increased when Epinephrine is combined with Hydrochlorothiazide.
Epirubicin Epirubicin The risk or severity of neutropenia and thrombocytopenia can be increased when Epirubicin is combined with Hydrochlorothiazide.
Eplerenone Eplerenone The therapeutic efficacy of Hydrochlorothiazide can be increased when used in combination with Eplerenone.
Escitalopram Escitalopram The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Escitalopram.
Zonisamide Zonisamide Hydrochlorothiazide may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Aripiprazole Aripiprazole The risk or severity of hypotension can be increased when Aripiprazole is combined with Hydrochlorothiazide.
Atomoxetine Atomoxetine Hydrochlorothiazide may decrease the excretion rate of Atomoxetine which could result in a higher serum level.
Dexmethylphenidate Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Hydrochlorothiazide.
Atazanavir Atazanavir The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Atazanavir.
Almotriptan Almotriptan Hydrochlorothiazide may decrease the excretion rate of Almotriptan which could result in a higher serum level.
Eletriptan Eletriptan Eletriptan may decrease the antihypertensive activities of Hydrochlorothiazide.
Mefloquine Mefloquine The risk or severity of QTc prolongation can be increased when Mefloquine is combined with Hydrochlorothiazide.
Polyethylene Glycol 3350 Polyethylene Glycol 3350 The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Polyethylene glycol.
Rosuvastatin Rosuvastatin The excretion of Hydrochlorothiazide can be decreased when combined with Rosuvastatin.
Vardenafil Vardenafil The risk or severity of QTc prolongation can be increased when Vardenafil is combined with Hydrochlorothiazide.
Alfuzosin Alfuzosin Alfuzosin may increase the hypotensive activities of Hydrochlorothiazide.
Emtricitabine Emtricitabine Hydrochlorothiazide may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine Memantine Hydrochlorothiazide may decrease the excretion rate of Memantine which could result in a higher serum level.
Tegaserod Tegaserod The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Tegaserod.
Tadalafil Tadalafil The therapeutic efficacy of Hydrochlorothiazide can be increased when used in combination with Tadalafil.
Frovatriptan Frovatriptan Frovatriptan may decrease the antihypertensive activities of Hydrochlorothiazide.
Gemifloxacin Gemifloxacin The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Gemifloxacin.
Apomorphine Injection Apomorphine Injection The risk or severity of QTc prolongation can be increased when Apomorphine is combined with Hydrochlorothiazide.
Protriptyline Protriptyline The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Hydrochlorothiazide.
Duloxetine Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Hydrochlorothiazide is combined with Duloxetine.
Tinidazole Tinidazole Hydrochlorothiazide may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Trospium Trospium The serum concentration of Hydrochlorothiazide can be increased when it is combined with Trospium.
Bosentan Bosentan The therapeutic efficacy of Bosentan can be increased when used in combination with Hydrochlorothiazide.
Cefditoren Cefditoren Hydrochlorothiazide may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cyanocobalamin Injection Cyanocobalamin Injection Hydrochlorothiazide may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
Erlotinib Erlotinib The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Erlotinib.
Eszopiclone Eszopiclone Hydrochlorothiazide may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Ganciclovir Ganciclovir Hydrochlorothiazide may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Insulin Aspart (rDNA Origin) Injection Insulin Aspart (rDNA Origin) Injection The therapeutic efficacy of Insulin aspart can be decreased when used in combination with Hydrochlorothiazide.
Ribavirin Ribavirin Hydrochlorothiazide may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Solifenacin Solifenacin The risk or severity of QTc prolongation can be increased when Solifenacin is combined with Hydrochlorothiazide.
Valganciclovir Valganciclovir Hydrochlorothiazide may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole Voriconazole The risk or severity of QTc prolongation can be increased when Voriconazole is combined with Hydrochlorothiazide.
Zoledronic Acid Injection Zoledronic Acid Injection The risk or severity of nephrotoxicity and hypocalcemia can be increased when Hydrochlorothiazide is combined with Zoledronic acid.
Adefovir Adefovir The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Adefovir.
Dextroamphetamine Dextroamphetamine Amphetamine may increase the hypotensive activities of Hydrochlorothiazide.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Peginterferon alfa-2a.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Peginterferon alfa-2b.
Pramlintide Injection Pramlintide Injection The therapeutic efficacy of Pramlintide can be decreased when used in combination with Hydrochlorothiazide.
Exenatide Injection Exenatide Injection The therapeutic efficacy of Exenatide can be decreased when used in combination with Hydrochlorothiazide.
Ibandronate Ibandronate The risk or severity of nephrotoxicity and hypocalcemia can be increased when Hydrochlorothiazide is combined with Ibandronate.
Isocarboxazid Isocarboxazid Isocarboxazid may increase the hypotensive activities of Hydrochlorothiazide.
Ramelteon Ramelteon Hydrochlorothiazide may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Darifenacin Darifenacin The serum concentration of Hydrochlorothiazide can be increased when it is combined with Darifenacin.
Fentanyl Fentanyl Fentanyl may decrease the excretion rate of Hydrochlorothiazide which could result in a higher serum level.
Pregabalin Pregabalin Hydrochlorothiazide may decrease the excretion rate of Pregabalin which could result in a higher serum level.
Phenylephrine Phenylephrine Phenylephrine may decrease the antihypertensive activities of Hydrochlorothiazide.
Felbamate Felbamate The risk or severity of QTc prolongation can be increased when Felbamate is combined with Hydrochlorothiazide.
Insulin Detemir (rDNA Origin) Injection Insulin Detemir (rDNA Origin) Injection The therapeutic efficacy of Insulin detemir can be decreased when used in combination with Hydrochlorothiazide.
Ranolazine Ranolazine The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Ranolazine.
Rasagiline Rasagiline Rasagiline may increase the hypotensive activities of Hydrochlorothiazide.
Imatinib Imatinib The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Imatinib.
Sitagliptin Sitagliptin The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Hydrochlorothiazide.
Varenicline Varenicline Hydrochlorothiazide may decrease the excretion rate of Varenicline which could result in a higher serum level.
Albuterol Albuterol Hydrochlorothiazide may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone Paliperidone The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Paliperidone.
Bortezomib Bortezomib The risk or severity of QTc prolongation can be increased when Bortezomib is combined with Hydrochlorothiazide.
Clofarabine Injection Clofarabine Injection Hydrochlorothiazide may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Hydrochlorothiazide.
Lubiprostone Lubiprostone Hydrochlorothiazide may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Oxaliplatin.
Posaconazole Posaconazole The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Posaconazole.
Primaquine Primaquine The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Primaquine.
Rituximab Injection Rituximab Injection Hydrochlorothiazide may increase the hypotensive activities of Rituximab.
Pemetrexed Injection Pemetrexed Injection Hydrochlorothiazide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dimenhydrinate Dimenhydrinate The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Dimenhydrinate.
Lisdexamfetamine Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Hydrochlorothiazide.
Nabilone Nabilone The risk or severity of adverse effects can be increased when Nabilone is combined with Hydrochlorothiazide.
Vorinostat Vorinostat The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Vorinostat.
Sorafenib Sorafenib Hydrochlorothiazide may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Sunitinib Sunitinib The therapeutic efficacy of Sunitinib can be decreased when used in combination with Hydrochlorothiazide.
Lapatinib Lapatinib The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Lapatinib.
Levocetirizine Levocetirizine Hydrochlorothiazide may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Hydrochlorothiazide may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib Dasatinib The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Dasatinib.
Azacitidine Injection Azacitidine Injection Hydrochlorothiazide may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Paclitaxel (with polyoxyethylated castor oil) Injection Paclitaxel (with polyoxyethylated castor oil) Injection The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Castor oil.
Temsirolimus Temsirolimus The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Temsirolimus.
Nelarabine Injection Nelarabine Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Nelarabine.
Lenalidomide Lenalidomide Hydrochlorothiazide may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Nilotinib Nilotinib The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Nilotinib.
Toremifene Toremifene The risk or severity of hypercalcemia can be increased when Hydrochlorothiazide is combined with Toremifene.
Bexarotene Bexarotene The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Bexarotene.
Budesonide Budesonide The risk or severity of electrolyte imbalance can be increased when Budesonide is combined with Hydrochlorothiazide.
Chloramphenicol Injection Chloramphenicol Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Chloramphenicol.
Decitabine Injection Decitabine Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Decitabine.
Desmopressin Desmopressin Hydrochlorothiazide may decrease the excretion rate of Desmopressin which could result in a higher serum level.
Doripenem Injection Doripenem Injection Hydrochlorothiazide may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Arsenic trioxide.
Mitoxantrone Injection Mitoxantrone Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The risk or severity of hyponatremia can be increased when Desvenlafaxine is combined with Hydrochlorothiazide.
Cevimeline Cevimeline Hydrochlorothiazide may decrease the excretion rate of Cevimeline which could result in a higher serum level.
Nebivolol Nebivolol The therapeutic efficacy of Nebivolol can be increased when used in combination with Hydrochlorothiazide.
Tretinoin Tretinoin The risk or severity of adverse effects can be increased when Tretinoin is combined with Hydrochlorothiazide.
Bendamustine Injection Bendamustine Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Bendamustine.
Leucovorin Injection Leucovorin Injection The excretion of Hydrochlorothiazide can be decreased when combined with Leucovorin.
Flecainide Flecainide The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Flecainide.
Certolizumab Injection Certolizumab Injection Hydrochlorothiazide may decrease the excretion rate of Certolizumab pegol which could result in a higher serum level.
Ixabepilone Injection Ixabepilone Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Ixabepilone.
Irinotecan Injection Irinotecan Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Irinotecan.
Daptomycin Injection Daptomycin Injection Hydrochlorothiazide may decrease the excretion rate of Daptomycin which could result in a higher serum level.
Methylnaltrexone Injection Methylnaltrexone Injection Hydrochlorothiazide may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Alemtuzumab.
Midazolam Midazolam Hydrochlorothiazide may decrease the excretion rate of Midazolam which could result in a higher serum level.
Naltrexone Injection Naltrexone Injection The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Naltrexone.
Dexrazoxane Injection Dexrazoxane Injection Hydrochlorothiazide may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
Ibritumomab Injection Ibritumomab Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Ibritumomab tiuxetan.
Milnacipran Milnacipran The risk or severity of hyponatremia can be increased when Milnacipran is combined with Hydrochlorothiazide.
Plerixafor Injection Plerixafor Injection Hydrochlorothiazide may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Sodium Phosphate Sodium Phosphate Hydrochlorothiazide may increase the nephrotoxic activities of Sodium phosphate, monobasic.
Febuxostat Febuxostat The therapeutic efficacy of Febuxostat can be decreased when used in combination with Hydrochlorothiazide.
Fesoterodine Fesoterodine Hydrochlorothiazide may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Degarelix Injection Degarelix Injection The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Degarelix.
Betaxolol Betaxolol The therapeutic efficacy of Betaxolol can be increased when used in combination with Hydrochlorothiazide.
Iloperidone Iloperidone The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Iloperidone.
Prasugrel Prasugrel Hydrochlorothiazide may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Everolimus Everolimus The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Everolimus.
Dronedarone Dronedarone The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Dronedarone.
Pralatrexate Injection Pralatrexate Injection Hydrochlorothiazide may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection Hydrochlorothiazide may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Saxagliptin Saxagliptin The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Hydrochlorothiazide.
Telavancin Injection Telavancin Injection The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Telavancin.
Romidepsin Injection Romidepsin Injection The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Romidepsin.
Tapentadol Tapentadol The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Tapentadol.
Topotecan Topotecan Hydrochlorothiazide may decrease the excretion rate of Topotecan which could result in a higher serum level.
Rasburicase Injection Rasburicase Injection The therapeutic efficacy of Rasburicase can be decreased when used in combination with Hydrochlorothiazide.
Pazopanib Pazopanib The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Pazopanib.
Asenapine Asenapine The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Asenapine.
Oxymorphone Oxymorphone The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Oxymorphone.
Dabigatran Dabigatran The therapeutic efficacy of Dabigatran can be decreased when used in combination with Hydrochlorothiazide.
Liraglutide Injection Liraglutide Injection The therapeutic efficacy of Liraglutide can be decreased when used in combination with Hydrochlorothiazide.
Dalfampridine Dalfampridine Hydrochlorothiazide may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Eribulin Injection Eribulin Injection The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Eribulin.
Cabazitaxel Injection Cabazitaxel Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Cabazitaxel.
Ceftaroline Injection Ceftaroline Injection The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Ceftaroline fosamil.
Pegloticase Injection Pegloticase Injection The therapeutic efficacy of Pegloticase can be decreased when used in combination with Hydrochlorothiazide.
Lurasidone Lurasidone The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection Hydrochlorothiazide may decrease the excretion rate of Acetaminophen which could result in a higher serum level.
Vilazodone Vilazodone Vilazodone may decrease the antihypertensive activities of Hydrochlorothiazide.
Ipilimumab Injection Ipilimumab Injection Hydrochlorothiazide may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Hydrochlorothiazide may decrease the excretion rate of Aldesleukin which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Hydrochlorothiazide may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Azilsartan Azilsartan Hydrochlorothiazide may increase the hypotensive and Electrolyte Disturbance activities of Azilsartan medoxomil.
Busulfan Injection Busulfan Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Busulfan.
Roflumilast Roflumilast Hydrochlorothiazide may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Linagliptin Linagliptin The therapeutic efficacy of Linagliptin can be decreased when used in combination with Hydrochlorothiazide.
Rilpivirine Rilpivirine The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Rilpivirine.
Cyclophosphamide Injection Cyclophosphamide Injection The risk or severity of granulocytopenia can be increased when Hydrochlorothiazide is combined with Cyclophosphamide.
Triptorelin Injection Triptorelin Injection The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Triptorelin.
Rivaroxaban Rivaroxaban Hydrochlorothiazide may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor Ticagrelor The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Hydrochlorothiazide.
Ruxolitinib Ruxolitinib Hydrochlorothiazide may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Vandetanib Vandetanib The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Vandetanib.
Clobazam Clobazam Hydrochlorothiazide may decrease the excretion rate of Clobazam which could result in a higher serum level.
Vemurafenib Vemurafenib The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Vemurafenib.
Deferiprone Deferiprone Hydrochlorothiazide may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Crizotinib Crizotinib The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Crizotinib.
Melphalan Injection Melphalan Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Melphalan.
Cabergoline Cabergoline Cabergoline may decrease the antihypertensive activities of Hydrochlorothiazide.
Naloxone Injection Naloxone Injection Naloxone may decrease the excretion rate of Hydrochlorothiazide which could result in a higher serum level.
Ambrisentan Ambrisentan The therapeutic efficacy of Ambrisentan can be increased when used in combination with Hydrochlorothiazide.
Fondaparinux Injection Fondaparinux Injection Hydrochlorothiazide may decrease the excretion rate of Fondaparinux which could result in a higher serum level.
Carfilzomib Injection Carfilzomib Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Carfilzomib.
Iloprost Iloprost Iloprost may increase the hypotensive activities of Hydrochlorothiazide.
Enzalutamide Enzalutamide Hydrochlorothiazide may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron Mirabegron Hydrochlorothiazide may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Bosutinib Bosutinib The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The risk or severity of electrolyte imbalance can be increased when Corticotropin is combined with Hydrochlorothiazide.
Linaclotide Linaclotide The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Linaclotide.
Teriflunomide Teriflunomide The excretion of Hydrochlorothiazide can be decreased when combined with Teriflunomide.
Lorcaserin Lorcaserin The therapeutic efficacy of Mecasermin can be decreased when used in combination with Hydrochlorothiazide.
Teduglutide Injection Teduglutide Injection Hydrochlorothiazide may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Bedaquiline Bedaquiline The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Bedaquiline.
Tofacitinib Tofacitinib The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Tofacitinib.
Alogliptin Alogliptin The therapeutic efficacy of Alogliptin can be decreased when used in combination with Hydrochlorothiazide.
Ponatinib Ponatinib The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Ponatinib.
Pomalidomide Pomalidomide Hydrochlorothiazide may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Trastuzumab emtansine.
Apixaban Apixaban The therapeutic efficacy of Apixaban can be decreased when used in combination with Hydrochlorothiazide.
Canagliflozin Canagliflozin The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Hydrochlorothiazide.
Methazolamide Methazolamide The risk or severity of adverse effects can be increased when Methazolamide is combined with Hydrochlorothiazide.
Dabrafenib Dabrafenib The excretion of Dabrafenib can be decreased when combined with Hydrochlorothiazide.
Trametinib Trametinib Hydrochlorothiazide may decrease the excretion rate of Trametinib which could result in a higher serum level.
Dolutegravir Dolutegravir The excretion of Hydrochlorothiazide can be decreased when combined with Dolutegravir.
Levomilnacipran Levomilnacipran The risk or severity of hyponatremia can be increased when Levomilnacipran is combined with Hydrochlorothiazide.
Ertapenem Injection Ertapenem Injection Hydrochlorothiazide may decrease the excretion rate of Ertapenem which could result in a higher serum level.
Vortioxetine Vortioxetine Hydrochlorothiazide may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ibrutinib Ibrutinib The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Ibrutinib.
Avanafil Avanafil Avanafil may increase the antihypertensive activities of Hydrochlorothiazide.
Ketorolac Injection Ketorolac Injection The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Ketorolac.
Obinutuzumab Injection Obinutuzumab Injection Hydrochlorothiazide may increase the hypotensive activities of Obinutuzumab.
Sofosbuvir Sofosbuvir Hydrochlorothiazide may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin The therapeutic efficacy of Dapagliflozin can be decreased when used in combination with Hydrochlorothiazide.
Apremilast Apremilast Hydrochlorothiazide may decrease the excretion rate of Apremilast which could result in a higher serum level.
Droxidopa Droxidopa The risk or severity of Cardiac Arrhythmia can be increased when Droxidopa is combined with Hydrochlorothiazide.
Ceritinib Ceritinib The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Ceritinib.
Albiglutide Injection Albiglutide Injection The therapeutic efficacy of Albiglutide can be decreased when used in combination with Hydrochlorothiazide.
Belinostat Injection Belinostat Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Belinostat.
Testosterone Injection Testosterone Injection Hydrochlorothiazide may decrease the excretion rate of Testosterone which could result in a higher serum level.
Empagliflozin Empagliflozin Hydrochlorothiazide may increase the diuretic activities of Empagliflozin.
Vorapaxar Vorapaxar The therapeutic efficacy of Vorapaxar can be decreased when used in combination with Hydrochlorothiazide.
Hydrocodone Hydrocodone The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Hydrocodone.
Dulaglutide Injection Dulaglutide Injection The therapeutic efficacy of Dulaglutide can be decreased when used in combination with Hydrochlorothiazide.
Edoxaban Edoxaban Hydrochlorothiazide may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Peginterferon beta-1a.
Olaparib Olaparib The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Olaparib.
Blinatumomab Injection Blinatumomab Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Blinatumomab.
Methamphetamine Methamphetamine Hydrochlorothiazide may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Tasimelteon Tasimelteon Hydrochlorothiazide may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Riociguat Riociguat The therapeutic efficacy of Riociguat can be increased when used in combination with Hydrochlorothiazide.
Risperidone Injection Risperidone Injection Hydrochlorothiazide may increase the hypotensive activities of Risperidone.
Palbociclib Palbociclib The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Palbociclib.
Insulin Human Inhalation Insulin Human Inhalation The therapeutic efficacy of Insulin human can be decreased when used in combination with Hydrochlorothiazide.
Lenvatinib Lenvatinib The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Lenvatinib.
Panobinostat Panobinostat The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Panobinostat.
Dinutuximab Injection Dinutuximab Injection The risk or severity of adverse effects can be increased when Dinutuximab is combined with Hydrochlorothiazide.
Haloperidol Injection Haloperidol Injection The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Haloperidol.
Ivabradine Ivabradine The risk or severity of Cardiac Arrhythmia can be increased when Hydrochlorothiazide is combined with Ivabradine.
Macitentan Macitentan The therapeutic efficacy of Macitentan can be increased when used in combination with Hydrochlorothiazide.
Flibanserin Flibanserin Flibanserin may decrease the antihypertensive activities of Hydrochlorothiazide.
Prednisolone Prednisolone The risk or severity of electrolyte imbalance can be increased when Prednisolone is combined with Hydrochlorothiazide.
Brexpiprazole Brexpiprazole Brexpiprazole may decrease the antihypertensive activities of Hydrochlorothiazide.
Ziprasidone Injection Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Ziprasidone.
Cariprazine Cariprazine Cariprazine may decrease the antihypertensive activities of Hydrochlorothiazide.
Penicillin G Procaine Injection Penicillin G Procaine Injection Hydrochlorothiazide may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline Eluxadoline The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Eluxadoline.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The therapeutic efficacy of Insulin degludec can be decreased when used in combination with Hydrochlorothiazide.
Trabectedin Injection Trabectedin Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Trabectedin.
Ixazomib Ixazomib Hydrochlorothiazide may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lesinurad Lesinurad The therapeutic efficacy of Lesinurad can be decreased when used in combination with Hydrochlorothiazide.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The risk or severity of electrolyte imbalance can be increased when Amphotericin B is combined with Hydrochlorothiazide.
Dexamethasone Injection Dexamethasone Injection The risk or severity of electrolyte imbalance can be increased when Dexamethasone is combined with Hydrochlorothiazide.
Defibrotide Injection Defibrotide Injection The therapeutic efficacy of Defibrotide can be decreased when used in combination with Hydrochlorothiazide.
Brivaracetam Injection Brivaracetam Injection Hydrochlorothiazide may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
Midodrine Midodrine Midodrine may decrease the antihypertensive activities of Hydrochlorothiazide.
Selexipag Selexipag The therapeutic efficacy of Selexipag can be increased when used in combination with Hydrochlorothiazide.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of QTc prolongation can be increased when Diphenhydramine is combined with Hydrochlorothiazide.
Calcifediol Calcifediol The risk or severity of hypercalcemia can be increased when Hydrochlorothiazide is combined with Calcifediol.
Ergocalciferol Ergocalciferol The risk or severity of hypercalcemia can be increased when Hydrochlorothiazide is combined with Ergocalciferol.
Doxercalciferol Doxercalciferol The risk or severity of hypercalcemia can be increased when Hydrochlorothiazide is combined with Doxercalciferol.
Furosemide Injection Furosemide Injection The therapeutic efficacy of Hydrochlorothiazide can be increased when used in combination with Furosemide.
Rucaparib Rucaparib The excretion of Hydrochlorothiazide can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Hydrochlorothiazide.
Ribociclib Ribociclib The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Ribociclib.
Doxepin (Insomnia) Doxepin (Insomnia) Doxepin may decrease the excretion rate of Hydrochlorothiazide which could result in a higher serum level.
Plecanatide Plecanatide The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Plecanatide.
Deutetrabenazine Deutetrabenazine The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Deutetrabenazine.
Valbenazine Valbenazine Hydrochlorothiazide may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort Deflazacort The risk or severity of electrolyte imbalance can be increased when Deflazacort is combined with Hydrochlorothiazide.
Safinamide Safinamide Safinamide may increase the hypotensive activities of Hydrochlorothiazide.
Edaravone Injection Edaravone Injection The excretion of Edaravone can be decreased when combined with Hydrochlorothiazide.
Naldemedine Naldemedine Hydrochlorothiazide may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Enasidenib Enasidenib The excretion of Hydrochlorothiazide can be decreased when combined with Enasidenib.
Benznidazole Benznidazole Hydrochlorothiazide may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin Hydrochlorothiazide may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Betrixaban Betrixaban The therapeutic efficacy of Betrixaban can be decreased when used in combination with Hydrochlorothiazide.
Gemtuzumab Ozogamicin Injection Gemtuzumab Ozogamicin Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Gemtuzumab ozogamicin.
Letermovir Letermovir The excretion of Hydrochlorothiazide can be decreased when combined with Letermovir.
Semaglutide Injection Semaglutide Injection The therapeutic efficacy of Semaglutide can be decreased when used in combination with Hydrochlorothiazide.
Tetrabenazine Tetrabenazine The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Tetrabenazine.
Ertugliflozin Ertugliflozin The therapeutic efficacy of Ertugliflozin can be decreased when used in combination with Hydrochlorothiazide.
Buprenorphine Injection Buprenorphine Injection The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Buprenorphine.
Apalutamide Apalutamide Hydrochlorothiazide may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Penicillamine Penicillamine The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Penicillamine.
Fostamatinib Fostamatinib Fostamatinib may increase the antihypertensive activities of Hydrochlorothiazide.
Avatrombopag Avatrombopag The excretion of Hydrochlorothiazide can be decreased when combined with Avatrombopag.
Baricitinib Baricitinib Hydrochlorothiazide may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine The therapeutic efficacy of Lofexidine can be increased when used in combination with Hydrochlorothiazide.
Plazomicin Injection Plazomicin Injection Hydrochlorothiazide may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat Eliglustat The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Eliglustat.
Encorafenib Encorafenib The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Encorafenib.
Ivosidenib Ivosidenib The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Ivosidenib.
Cannabidiol Cannabidiol Cannabidiol may decrease the antihypertensive activities of Hydrochlorothiazide.
Stiripentol Stiripentol Hydrochlorothiazide may decrease the excretion rate of Stiripentol which could result in a higher serum level.
Gilteritinib Gilteritinib The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Gilteritinib.
Glasdegib Glasdegib The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Glasdegib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The risk or severity of adverse effects can be increased when Paclitaxel is combined with Hydrochlorothiazide.
Prucalopride Prucalopride Hydrochlorothiazide may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Magnesium Citrate Magnesium Citrate The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Magnesium citrate.
Siponimod Siponimod Siponimod may decrease the antihypertensive activities of Hydrochlorothiazide.
Acyclovir Ophthalmic Acyclovir Ophthalmic The risk or severity of nephrotoxicity can be increased when Acyclovir is combined with Hydrochlorothiazide.
Esomeprazole Injection Esomeprazole Injection The excretion of Hydrochlorothiazide can be decreased when combined with Esomeprazole.
Cladribine Cladribine The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Cladribine.
Solriamfetol Solriamfetol Hydrochlorothiazide may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Triclabendazole Triclabendazole The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Triclabendazole.
Entrectinib Entrectinib The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Entrectinib.
Pitolisant Pitolisant Hydrochlorothiazide may increase the QTc-prolonging activities of Pitolisant.
Lefamulin Lefamulin Lefamulin may increase the QTc-prolonging activities of Hydrochlorothiazide.
Calcium Acetate Calcium Acetate Hydrochlorothiazide may decrease the excretion rate of Calcium acetate which could result in a higher serum level.
Selpercatinib Selpercatinib Selpercatinib may decrease the antihypertensive activities of Hydrochlorothiazide.
Fostemsavir Fostemsavir The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Fostemsavir.
Octreotide Octreotide The risk or severity of QTc prolongation can be increased when Octreotide is combined with Hydrochlorothiazide.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection Naxitamab may decrease the antihypertensive activities of Hydrochlorothiazide.
Relugolix Relugolix The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Relugolix.
Cabotegravir Cabotegravir The excretion of Hydrochlorothiazide can be decreased when combined with Cabotegravir.
Viloxazine Viloxazine Hydrochlorothiazide may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Hydrochlorothiazide which could result in a higher serum level.
Fenoprofen Fenoprofen The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Fenoprofen.
Indomethacin Indomethacin The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Indomethacin.
Mefenamic Acid Mefenamic Acid The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Mefenamic acid.
Naproxen Naproxen The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Naproxen.
Tolmetin Tolmetin The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Tolmetin.
Sulindac Sulindac The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Sulindac.
Trazodone Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Hydrochlorothiazide.
Isotretinoin Isotretinoin Hydrochlorothiazide may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Hydrochlorothiazide may decrease the excretion rate of Sucralfate which could result in a higher serum level.
Hydroxyurea Hydroxyurea The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Hydroxyurea.
Floxuridine Floxuridine Hydrochlorothiazide may decrease the excretion rate of Floxuridine which could result in a higher serum level.
Phenobarbital Phenobarbital The risk or severity of hypotension and orthostatic hypotension can be increased when Phenobarbital is combined with Hydrochlorothiazide.
Metaxalone Metaxalone Hydrochlorothiazide may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Methotrexate.
Levorphanol Levorphanol The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Levorphanol.
Primidone Primidone The risk or severity of hypotension and orthostatic hypotension can be increased when Primidone is combined with Hydrochlorothiazide.
Methsuximide Methsuximide The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Methsuximide.
Diethylpropion Diethylpropion Diethylpropion may decrease the antihypertensive activities of Hydrochlorothiazide.
Chlorpromazine Chlorpromazine The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Chlorpromazine.
Diazepam Diazepam Hydrochlorothiazide may decrease the excretion rate of Diazepam which could result in a higher serum level.
Oxazepam Oxazepam Hydrochlorothiazide may decrease the excretion rate of Oxazepam which could result in a higher serum level.
Flurazepam Flurazepam Hydrochlorothiazide may decrease the excretion rate of Flurazepam which could result in a higher serum level.
Clorazepate Clorazepate Hydrochlorothiazide may decrease the excretion rate of Clorazepic acid which could result in a higher serum level.
Lorazepam Lorazepam Hydrochlorothiazide may decrease the excretion rate of Lorazepam which could result in a higher serum level.
Phenoxybenzamine Phenoxybenzamine The therapeutic efficacy of Hydrochlorothiazide can be increased when used in combination with Phenoxybenzamine.
Carmustine Carmustine Hydrochlorothiazide may decrease the excretion rate of Carmustine which could result in a higher serum level.
Amantadine Amantadine Hydrochlorothiazide may decrease the excretion rate of Amantadine which could result in a higher serum level.
Codeine Codeine Hydrochlorothiazide may decrease the excretion rate of Codeine which could result in a higher serum level.
Bromocriptine Bromocriptine The therapeutic efficacy of Bromocriptine can be decreased when used in combination with Hydrochlorothiazide.
Metaproterenol Metaproterenol Orciprenaline may increase the hypokalemic activities of Hydrochlorothiazide.
Tranylcypromine Tranylcypromine Tranylcypromine may increase the hypotensive activities of Hydrochlorothiazide.
Phenelzine Phenelzine Phenelzine may increase the hypotensive activities of Hydrochlorothiazide.
Procarbazine Procarbazine Procarbazine may increase the hypotensive activities of Hydrochlorothiazide.
Ergoloid Mesylates Ergoloid Mesylates Ergoloid mesylate may decrease the antihypertensive activities of Hydrochlorothiazide.
Tetracycline Tetracycline Hydrochlorothiazide may decrease the excretion rate of Tetracycline which could result in a higher serum level.
Thioguanine Thioguanine The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Tioguanine.
Minocycline Minocycline The excretion of Hydrochlorothiazide can be decreased when combined with Minocycline.
Prochlorperazine Prochlorperazine The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Prochlorperazine.
Thioridazine Thioridazine The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Thioridazine.
Trifluoperazine Trifluoperazine Trifluoperazine may decrease the antihypertensive activities of Hydrochlorothiazide.
Bleomycin Bleomycin Hydrochlorothiazide may decrease the excretion rate of Bleomycin which could result in a higher serum level.
Sulfadiazine Sulfadiazine The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Hydrochlorothiazide.
Oxycodone Oxycodone The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Oxycodone.
Methadone Methadone The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Methadone.
Oxybutynin Oxybutynin The serum concentration of Hydrochlorothiazide can be increased when it is combined with Oxybutynin.
Benztropine Benztropine Hydrochlorothiazide may decrease the excretion rate of Benzatropine which could result in a higher serum level.
Colestipol Colestipol Colestipol can cause a decrease in the absorption of Hydrochlorothiazide resulting in a reduced serum concentration and potentially a decrease in efficacy.
Maprotiline Maprotiline Hydrochlorothiazide may decrease the excretion rate of Maprotiline which could result in a higher serum level.
Ibuprofen Ibuprofen The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Ibuprofen.
Trihexyphenidyl Trihexyphenidyl The serum concentration of Hydrochlorothiazide can be increased when it is combined with Trihexyphenidyl.
Orphenadrine Orphenadrine The risk or severity of QTc prolongation can be increased when Orphenadrine is combined with Hydrochlorothiazide.
Azathioprine Azathioprine Hydrochlorothiazide may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Phentermine Phentermine Phentermine may decrease the antihypertensive activities of Hydrochlorothiazide.
Methylphenidate Methylphenidate Methylphenidate may decrease the antihypertensive activities of Hydrochlorothiazide.
Amoxapine Amoxapine The risk or severity of QTc prolongation can be increased when Amoxapine is combined with Hydrochlorothiazide.
Sulfasalazine Sulfasalazine The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Sulfasalazine.
Hydrocortisone Hydrocortisone The risk or severity of electrolyte imbalance can be increased when Hydrocortisone is combined with Hydrochlorothiazide.
Lomustine Lomustine The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Lomustine.
Doxorubicin Doxorubicin The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Doxorubicin.
Cytarabine Cytarabine The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Cytarabine.
Mechlorethamine Mechlorethamine The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Mechlorethamine.
Dactinomycin Dactinomycin The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Dactinomycin.
Phenazopyridine Phenazopyridine The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Phenazopyridine.
Carbamazepine Carbamazepine The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Carbamazepine.
Clonidine Clonidine The risk or severity of hypotension can be increased when Clonidine is combined with Hydrochlorothiazide.
Prazosin Prazosin The risk or severity of hypotension can be increased when Prazosin is combined with Hydrochlorothiazide.
Cimetidine Cimetidine Hydrochlorothiazide may decrease the excretion rate of Cimetidine which could result in a higher serum level.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Hydrochlorothiazide which could result in a higher serum level.
Warfarin Warfarin Hydrochlorothiazide may decrease the excretion rate of Warfarin which could result in a higher serum level.
Clonazepam Clonazepam Hydrochlorothiazide may decrease the excretion rate of Clonazepam which could result in a higher serum level.
Loperamide Loperamide The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Loperamide.
Promethazine Promethazine Hydrochlorothiazide may decrease the excretion rate of Promethazine which could result in a higher serum level.
Meclofenamate Meclofenamate The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Meclofenamic acid.
Daunorubicin Daunorubicin The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Daunorubicin.
Nitrofurantoin Nitrofurantoin Hydrochlorothiazide may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Methenamine Methenamine The therapeutic efficacy of Methenamine can be decreased when used in combination with Hydrochlorothiazide.
Digoxin Digoxin Hydrochlorothiazide may increase the hypokalemic activities of Digoxin.
Chloroquine Chloroquine The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Chloroquine.
Quinine Quinine The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of QTc prolongation can be increased when Ethosuximide is combined with Hydrochlorothiazide.
Calcitriol Calcitriol The risk or severity of hypercalcemia can be increased when Hydrochlorothiazide is combined with Calcitriol.
Lactulose Lactulose The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Lactulose.
Sulfinpyrazone Sulfinpyrazone The therapeutic efficacy of Sulfinpyrazone can be decreased when used in combination with Hydrochlorothiazide.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Hydrochlorothiazide can be increased when used in combination with Chlorothiazide.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Hydrochlorothiazide can be increased when used in combination with Chlorthalidone.
Metolazone Metolazone The therapeutic efficacy of Metolazone can be increased when used in combination with Hydrochlorothiazide.
Secobarbital Secobarbital The risk or severity of hypotension and orthostatic hypotension can be increased when Secobarbital is combined with Hydrochlorothiazide.
Desipramine Desipramine The risk or severity of QTc prolongation can be increased when Desipramine is combined with Hydrochlorothiazide.
Amitriptyline Amitriptyline Amitriptyline may decrease the excretion rate of Hydrochlorothiazide which could result in a higher serum level.
Imipramine Imipramine Imipramine may decrease the excretion rate of Hydrochlorothiazide which could result in a higher serum level.
Probenecid Probenecid The therapeutic efficacy of Probenecid can be decreased when used in combination with Hydrochlorothiazide.
Quinidine Quinidine Hydrochlorothiazide may decrease the excretion rate of Quinidine which could result in a higher serum level.
Procainamide Procainamide Hydrochlorothiazide may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid Hydrochlorothiazide may decrease the excretion rate of Isoniazid which could result in a higher serum level.
Pyrazinamide Pyrazinamide Hydrochlorothiazide may decrease the excretion rate of Pyrazinamide which could result in a higher serum level.
Rifampin Rifampin The excretion of Hydrochlorothiazide can be decreased when combined with Rifampicin.
Disopyramide Disopyramide The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Disopyramide.
Valproic Acid Valproic Acid The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Valproic acid.
Tamoxifen Tamoxifen The risk or severity of QTc prolongation can be increased when Tamoxifen is combined with Hydrochlorothiazide.
Mitomycin Mitomycin The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Mitomycin.
Butabarbital Butabarbital Hydrochlorothiazide may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Liothyronine Liothyronine Hydrochlorothiazide may decrease the excretion rate of Liothyronine which could result in a higher serum level.
Methimazole Methimazole Hydrochlorothiazide may decrease the excretion rate of Methimazole which could result in a higher serum level.
Propylthiouracil Propylthiouracil The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Propylthiouracil.
Chlorpropamide Chlorpropamide The therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Hydrochlorothiazide.
Tolbutamide Tolbutamide The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Hydrochlorothiazide.
Tolazamide Tolazamide The therapeutic efficacy of Tolazamide can be decreased when used in combination with Hydrochlorothiazide.
Dextromethorphan Dextromethorphan The serum concentration of Hydrochlorothiazide can be increased when it is combined with Dextromethorphan.
Dinoprostone Dinoprostone The excretion of Dinoprostone can be decreased when combined with Hydrochlorothiazide.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Hydrochlorothiazide.
Doxylamine Doxylamine The risk or severity of QTc prolongation can be increased when Doxylamine is combined with Hydrochlorothiazide.
Cyproheptadine Cyproheptadine The risk or severity of QTc prolongation can be increased when Cyproheptadine is combined with Hydrochlorothiazide.
Clemastine Clemastine The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Clemastine.
Chlorpheniramine Chlorpheniramine The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Chlorpheniramine.
Brompheniramine Brompheniramine The risk or severity of QTc prolongation can be increased when Dexbrompheniramine is combined with Hydrochlorothiazide.
Ethambutol Ethambutol Hydrochlorothiazide may decrease the excretion rate of Ethambutol which could result in a higher serum level.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Hydrochlorothiazide can be increased when used in combination with Methyclothiazide.
Chlorzoxazone Chlorzoxazone Hydrochlorothiazide may decrease the excretion rate of Chlorzoxazone which could result in a higher serum level.
Pyridoxine Pyridoxine Hydrochlorothiazide may decrease the excretion rate of Pyridoxine which could result in a higher serum level.
Folic Acid Folic Acid Hydrochlorothiazide may decrease the excretion rate of Folic acid which could result in a higher serum level.
Disulfiram Disulfiram The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Hydrochlorothiazide.
Minoxidil Minoxidil The therapeutic efficacy of Hydrochlorothiazide can be increased when used in combination with Minoxidil.
Pseudoephedrine Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Hydrochlorothiazide.
Nortriptyline Nortriptyline The risk or severity of QTc prolongation can be increased when Nortriptyline is combined with Hydrochlorothiazide.
Amphotericin B Injection Amphotericin B Injection The risk or severity of electrolyte imbalance can be increased when Amphotericin B is combined with Hydrochlorothiazide.
Mercaptopurine Mercaptopurine The excretion of Mercaptopurine can be decreased when combined with Hydrochlorothiazide.
Phytonadione Phytonadione Hydrochlorothiazide may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Hydrochlorothiazide which could result in a higher serum level.
Nadolol Nadolol The therapeutic efficacy of Nadolol can be increased when used in combination with Hydrochlorothiazide.
Butorphanol Injection Butorphanol Injection The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Butorphanol.
Nalbuphine Injection Nalbuphine Injection The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Nalbuphine.
Cholestyramine Resin Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Hydrochlorothiazide resulting in a reduced serum concentration and potentially a decrease in efficacy.
Allopurinol Allopurinol The risk of a hypersensitivity reaction to Allopurinol is increased when it is combined with Hydrochlorothiazide.
Oxytocin Injection Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Hydrochlorothiazide.
Flavoxate Flavoxate Hydrochlorothiazide may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Papaverine Papaverine The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Papaverine.
Fluorouracil Injection Fluorouracil Injection The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Fluorouracil.
Colchicine Colchicine The therapeutic efficacy of Colchicine can be decreased when used in combination with Hydrochlorothiazide.
Cefaclor Cefaclor The risk or severity of nephrotoxicity can be increased when Cefaclor is combined with Hydrochlorothiazide.
Cefadroxil Cefadroxil The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Cefadroxil.
Cefazolin Injection Cefazolin Injection The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Cefazolin.
Cephalexin Cephalexin The risk or severity of nephrotoxicity can be increased when Cephalexin is combined with Hydrochlorothiazide.
Cefoxitin Injection Cefoxitin Injection The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Cefoxitin.
Dacarbazine Dacarbazine Hydrochlorothiazide may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Cefotaxime Injection Cefotaxime Injection The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Hydrochlorothiazide.
Calcitonin Salmon Injection Calcitonin Salmon Injection Hydrochlorothiazide may decrease the excretion rate of Salmon calcitonin which could result in a higher serum level.
Ketoconazole Ketoconazole The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Ketoconazole.
Pyrantel Pyrantel Hydrochlorothiazide may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Thiotepa Injection Thiotepa Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Thiotepa.
Dipyridamole Dipyridamole Dipyridamole may increase the antihypertensive activities of Hydrochlorothiazide.
Isoxsuprine Isoxsuprine Isoxsuprine may decrease the antihypertensive activities of Hydrochlorothiazide.
Vinblastine Vinblastine The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Vinblastine.
Ethacrynic Acid Ethacrynic Acid The risk or severity of nephrotoxicity can be increased when Etacrynic acid is combined with Hydrochlorothiazide.
Colistimethate Injection Colistimethate Injection The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Colistimethate.
Hydroxyzine Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Hydrochlorothiazide.
Thiothixene Thiothixene The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Thiothixene.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Hydrochlorothiazide which could result in a higher serum level.
Salsalate Salsalate The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Salsalate.
Chlorambucil Chlorambucil The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Chlorambucil.
Alprazolam Alprazolam Hydrochlorothiazide may decrease the excretion rate of Alprazolam which could result in a higher serum level.
Temazepam Temazepam Hydrochlorothiazide may decrease the excretion rate of Temazepam which could result in a higher serum level.
Triazolam Triazolam Hydrochlorothiazide may decrease the excretion rate of Triazolam which could result in a higher serum level.
Dicyclomine Dicyclomine Hydrochlorothiazide may decrease the excretion rate of Dicyclomine which could result in a higher serum level.
Hyoscyamine Hyoscyamine The risk or severity of QTc prolongation can be increased when Hyoscyamine is combined with Hydrochlorothiazide.
Propantheline Propantheline Hydrochlorothiazide may decrease the excretion rate of Propantheline which could result in a higher serum level.
Trimethoprim Trimethoprim Hydrochlorothiazide may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Diltiazem Diltiazem The therapeutic efficacy of Diltiazem can be increased when used in combination with Hydrochlorothiazide.
Nifedipine Nifedipine The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Nifedipine.
Verapamil Verapamil Hydrochlorothiazide may decrease the excretion rate of Verapamil which could result in a higher serum level.
Atenolol Atenolol The therapeutic efficacy of Hydrochlorothiazide can be increased when used in combination with Atenolol.
Cisplatin Injection Cisplatin Injection Hydrochlorothiazide may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Diflunisal.
Piroxicam Piroxicam The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Piroxicam.
Bumetanide Bumetanide The risk or severity of nephrotoxicity can be increased when Bumetanide is combined with Hydrochlorothiazide.
Streptozocin Streptozocin The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Streptozocin.
Etoposide Etoposide The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Etoposide.
Glyburide Glyburide The therapeutic efficacy of Glyburide can be decreased when used in combination with Hydrochlorothiazide.
Glipizide Glipizide The therapeutic efficacy of Glipizide can be decreased when used in combination with Hydrochlorothiazide.
Indapamide Indapamide The therapeutic efficacy of Indapamide can be increased when used in combination with Hydrochlorothiazide.
Amoxicillin Amoxicillin Hydrochlorothiazide may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Hydrochlorothiazide may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline Pentoxifylline Pentoxifylline may increase the hypotensive activities of Hydrochlorothiazide.
Pentamidine Injection Pentamidine Injection The therapeutic efficacy of Pentamidine can be decreased when used in combination with Hydrochlorothiazide.
Ceftriaxone Injection Ceftriaxone Injection The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Ceftriaxone.
Labetalol Labetalol The therapeutic efficacy of Labetalol can be increased when used in combination with Hydrochlorothiazide.
Auranofin Auranofin Hydrochlorothiazide may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Leuprolide.
Gemfibrozil Gemfibrozil Hydrochlorothiazide may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
Guanabenz Guanabenz The therapeutic efficacy of Guanabenz can be increased when used in combination with Hydrochlorothiazide.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Hydrochlorothiazide.
Ceftazidime Injection Ceftazidime Injection The risk or severity of nephrotoxicity can be increased when Ceftazidime is combined with Hydrochlorothiazide.
Ketoprofen Ketoprofen The risk or severity of adverse effects can be increased when Ketoprofen is combined with Hydrochlorothiazide.
Cefotetan Injection Cefotetan Injection The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Cefotetan.
Pimozide Pimozide The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Pimozide.
Flurbiprofen Flurbiprofen The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Flurbiprofen.
Amiodarone Amiodarone The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Amiodarone.
Aztreonam Injection Aztreonam Injection Hydrochlorothiazide may decrease the excretion rate of Aztreonam which could result in a higher serum level.
Buspirone Buspirone Hydrochlorothiazide may decrease the excretion rate of Buspirone which could result in a higher serum level.
Ciprofloxacin Ciprofloxacin The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Ciprofloxacin.
Mesalamine Mesalamine The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Mesalazine.
Diclofenac Diclofenac The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Diclofenac.
Fluoxetine Fluoxetine The risk or severity of QTc prolongation can be increased when Fluoxetine is combined with Hydrochlorothiazide.
Nimodipine Nimodipine The therapeutic efficacy of Nimodipine can be increased when used in combination with Hydrochlorothiazide.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Interferon alfa-2b.
Clozapine Clozapine The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Clozapine.
Estazolam Estazolam Hydrochlorothiazide may decrease the excretion rate of Estazolam which could result in a higher serum level.
Idarubicin Idarubicin The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Idarubicin.
Ofloxacin Ofloxacin The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Ofloxacin.
Didanosine Didanosine Hydrochlorothiazide may decrease the excretion rate of Didanosine which could result in a higher serum level.
Fludarabine Injection Fludarabine Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Fludarabine.
Pentostatin Injection Pentostatin Injection Hydrochlorothiazide may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Clarithromycin Clarithromycin The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Clarithromycin.
Etodolac Etodolac The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Etodolac.
Felodipine Felodipine The therapeutic efficacy of Felodipine can be increased when used in combination with Hydrochlorothiazide.
Nabumetone Nabumetone The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Nabumetone.
Pravastatin Pravastatin The excretion of Hydrochlorothiazide can be decreased when combined with Pravastatin.
Teniposide Injection Teniposide Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Teniposide.
Itraconazole Itraconazole The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Itraconazole.
Oxaprozin Oxaprozin The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Oxaprozin.
Sotalol Sotalol The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Sotalol.
Doxazosin Doxazosin The therapeutic efficacy of Hydrochlorothiazide can be increased when used in combination with Doxazosin.
Terazosin Terazosin The therapeutic efficacy of Terazosin can be increased when used in combination with Hydrochlorothiazide.
Isradipine Isradipine The therapeutic efficacy of Isradipine can be increased when used in combination with Hydrochlorothiazide.
Cisapride Cisapride The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Cisapride.
Venlafaxine Venlafaxine Hydrochlorothiazide may decrease the excretion rate of Venlafaxine which could result in a higher serum level.
Stavudine Stavudine The excretion of Stavudine can be decreased when combined with Hydrochlorothiazide.
Fluvoxamine Fluvoxamine The risk or severity of hyponatremia can be increased when Fluvoxamine is combined with Hydrochlorothiazide.
Nefazodone Nefazodone The risk or severity of hyponatremia can be increased when Nefazodone is combined with Hydrochlorothiazide.
Lamotrigine Lamotrigine Hydrochlorothiazide may decrease the excretion rate of Lamotrigine which could result in a higher serum level.
Valacyclovir Valacyclovir The risk or severity of nephrotoxicity can be increased when Valaciclovir is combined with Hydrochlorothiazide.
Tramadol Tramadol The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Tramadol.
Vinorelbine Injection Vinorelbine Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Vinorelbine.
Carboplatin Injection Carboplatin Injection The risk or severity of nephrotoxicity can be increased when Carboplatin is combined with Hydrochlorothiazide.
Lansoprazole Lansoprazole The excretion of Hydrochlorothiazide can be decreased when combined with Lansoprazole.
Alprostadil Urogenital Alprostadil Urogenital The excretion of Alprostadil can be decreased when combined with Hydrochlorothiazide.
Ifosfamide Injection Ifosfamide Injection Hydrochlorothiazide may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Nicardipine Nicardipine The therapeutic efficacy of Hydrochlorothiazide can be increased when used in combination with Nicardipine.
Bupropion Bupropion Hydrochlorothiazide may decrease the excretion rate of Bupropion which could result in a higher serum level.
Ticlopidine Ticlopidine Hydrochlorothiazide may decrease the excretion rate of Ticlopidine which could result in a higher serum level.
Saquinavir Saquinavir The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Saquinavir.
Metformin Metformin The therapeutic efficacy of Metformin can be decreased when used in combination with Hydrochlorothiazide.
Dalteparin Injection Dalteparin Injection The therapeutic efficacy of Dalteparin can be decreased when used in combination with Hydrochlorothiazide.
Nisoldipine Nisoldipine The therapeutic efficacy of Nisoldipine can be increased when used in combination with Hydrochlorothiazide.
Lamivudine Lamivudine Hydrochlorothiazide may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Amifostine Injection Amifostine Injection Hydrochlorothiazide may increase the hypotensive activities of Amifostine.
Acarbose Acarbose The therapeutic efficacy of Acarbose can be decreased when used in combination with Hydrochlorothiazide.
Glimepiride Glimepiride The therapeutic efficacy of Glimepiride can be decreased when used in combination with Hydrochlorothiazide.
Gemcitabine Injection Gemcitabine Injection Hydrochlorothiazide may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Ritonavir Ritonavir The risk or severity of QTc prolongation can be increased when Ritonavir is combined with Hydrochlorothiazide.
Docetaxel Injection Docetaxel Injection The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Docetaxel.
Cidofovir Injection Cidofovir Injection The risk or severity of nephrotoxicity can be increased when Cidofovir is combined with Hydrochlorothiazide.
Meropenem Injection Meropenem Injection Hydrochlorothiazide may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine Clomipramine The risk or severity of QTc prolongation can be increased when Clomipramine is combined with Hydrochlorothiazide.
Fosfomycin Fosfomycin Hydrochlorothiazide may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine Mirtazapine The risk or severity of QTc prolongation can be increased when Mirtazapine is combined with Hydrochlorothiazide.
Trandolapril Trandolapril The therapeutic efficacy of Trandolapril can be increased when used in combination with Hydrochlorothiazide.
Topiramate Topiramate The risk or severity of hypokalemia can be increased when Hydrochlorothiazide is combined with Topiramate.
Insulin Lispro Injection Insulin Lispro Injection The therapeutic efficacy of Insulin lispro can be decreased when used in combination with Hydrochlorothiazide.
Pramipexole Pramipexole Hydrochlorothiazide may decrease the excretion rate of Pramipexole which could result in a higher serum level.
Nelfinavir Nelfinavir The risk or severity of QTc prolongation can be increased when Nelfinavir is combined with Hydrochlorothiazide.
Azithromycin Azithromycin The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Azithromycin.
Carvedilol Carvedilol The therapeutic efficacy of Carvedilol can be increased when used in combination with Hydrochlorothiazide.
Nilutamide Nilutamide Hydrochlorothiazide may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Flutamide Flutamide Hydrochlorothiazide may decrease the excretion rate of Flutamide which could result in a higher serum level.
Selegiline Selegiline Selegiline may increase the hypotensive activities of Hydrochlorothiazide.
Sertraline Sertraline The risk or severity of hyponatremia can be increased when Sertraline is combined with Hydrochlorothiazide.
Propafenone Propafenone The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Propafenone.
Tamsulosin Tamsulosin Hydrochlorothiazide may decrease the excretion rate of Tamsulosin which could result in a higher serum level.
Ropinirole Ropinirole The risk or severity of adverse effects can be increased when Ropinirole is combined with Hydrochlorothiazide.
Finasteride Finasteride Finasteride may decrease the antihypertensive activities of Hydrochlorothiazide.
Quetiapine Quetiapine Hydrochlorothiazide may increase the hypotensive activities of Quetiapine.
Cefepime Injection Cefepime Injection The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Cefepime.
Cefprozil Cefprozil The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Cefprozil.
Cefpodoxime Cefpodoxime The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Cefpodoxime.
Cetirizine Cetirizine Hydrochlorothiazide may decrease the excretion rate of Cetirizine which could result in a higher serum level.
Paroxetine Paroxetine The risk or severity of hyponatremia can be increased when Paroxetine is combined with Hydrochlorothiazide.
Tolcapone Tolcapone Hydrochlorothiazide may decrease the excretion rate of Tolcapone which could result in a higher serum level.
Citalopram Citalopram The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Citalopram.
Capecitabine Capecitabine Hydrochlorothiazide may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Efavirenz Efavirenz The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Efavirenz.
Abacavir Abacavir Hydrochlorothiazide may decrease the excretion rate of Abacavir which could result in a higher serum level.
Sildenafil Sildenafil Sildenafil may increase the antihypertensive activities of Hydrochlorothiazide.
Pioglitazone Pioglitazone The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Hydrochlorothiazide.
Celecoxib Celecoxib The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Celecoxib.
Rosiglitazone Rosiglitazone The therapeutic efficacy of Rosiglitazone can be decreased when used in combination with Hydrochlorothiazide.
Tolterodine Tolterodine Hydrochlorothiazide may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Thalidomide Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Hydrochlorothiazide.
Oseltamivir Oseltamivir Hydrochlorothiazide may decrease the excretion rate of Oseltamivir which could result in a higher serum level.
Colesevelam Colesevelam Colesevelam can cause a decrease in the absorption of Hydrochlorothiazide resulting in a reduced serum concentration and potentially a decrease in efficacy.
Balsalazide Balsalazide The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Balsalazide.
Nateglinide Nateglinide The therapeutic efficacy of Nateglinide can be decreased when used in combination with Hydrochlorothiazide.
Galantamine Galantamine The risk or severity of QTc prolongation can be increased when Galantamine is combined with Hydrochlorothiazide.
Rabeprazole Rabeprazole Hydrochlorothiazide may decrease the excretion rate of Rabeprazole which could result in a higher serum level.

* This branded product is no longer on the market. Generic alternatives may be available.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists