How Long Does Fluconazole Last In The Body?

The pharmacist answers our latest reader question regarding how long the drug fluonazole lasts in the body.


How long does Fluconazole last in the body (healthy adult)? Trying to gauge how long to wait before I can have a glass of wine.

Asked by Hollywood On May 10, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published May 10, 2022
Last updated Apr 12, 2024

Key points

  • Fluconazole has a long half-life and will take over 7 days for our body to metabolize the drug.

Hello and thanks for reaching out!

We are more than happy to answer this question regarding fluconazole for you.

What Is Fluconazole?

Fluconazole, also commonly known by the brand name Diflucan, is a synthetic antifungal agent that has a broad spectrum of activity and is indicated for the treatment of a wide variety of fungal infections.

Most commonly, it is used to treat yeast infections, and based on how the drug works, it oftentimes can be dosed as a single pill for treatment.

How Long Does Fluconazole Last In The Body?

The amount of time that it takes fluconazole to clear your system can vary greatly from person to person.

Fluconazole is mainly excreted by the kidneys, so having normal kidney function is a key component in determining the time it may take fluconazole to be cleared from your body.

If kidney function is normal, the half-life for fluconazole is anywhere from 20 to 50 hours with 30 hours considered to be average.

It takes around 5.5 half-lives for a drug to be considered cleared from the body.

If we use the average half-life for fluconazole (30 hours), this would lend that the average time it takes fluconazole to be cleared from the body of a healthy adult at 165 hours or just under 7 days.

If you ever wondered why you can often treat a yeast infection with just a single pill of fluconazole, this is why. It lasts an extremely long time in the body.

Alcohol With Fluconazole

Drinking alcohol while taking fluconazole is not contraindicated as they do not have any direct drug interactions.

However, alcohol should be used in moderation or with caution while taking fluconazole as it has the potential to increase the risk of gastrointestinal side effects.

Taking certain other anti-infective medications, such as metronidazole (which is an anti-protozoal/antibiotic), with alcohol can cause a "disulfiram-like" reaction.

A disulfiram-like reaction is caused by a medication or natural compound inducing a hypersensitive effect to alcohol, resulting in symptoms that can be severe and include:

  • Nausea
  • Vomiting
  • Headache
  • Abdominal discomfort
  • Flushing

Final Words

Thanks again for your question!

Don't hesitate to reach out if there is anything else we can help with!


  • Diflucan Prescribing Information, Pfizer
  • Fluconazole Monograph, PubChem

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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