Fluconazole

166 interactions 13 explained in plain English
Also sold as: Diflucan
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Contraindicated

Fluconazole Sertraline Explained Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details Fluconazole Buprenorphine Belbuca Explained An increased risk of QT interval prolongation, increased buprenorphine exposure and an increased risk of buprenorphine-related adv... Details Fluconazole Aripiprazole Injection Abilify Increased ARIPiprazole or ARIPiprazole lauroxil (prodrug of ARIPiprazole) exposure and an increased risk of QT interval prolongati... Details Fluconazole Alfuzosin UroXatral Increased alfuzosin exposure and an increased risk of QT interval prolongation Details Fluconazole Bedaquiline Sirturo Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details Fluconazole Dasatinib Phyrago An increased risk of QT interval prolongation and increased dasatinib exposure Details Fluconazole Deuruxolitinib Increased deuruxolitinib exposure and an increased risk of deuruxolitinib-related adverse effects such as thrombosis Details Fluconazole Dofetilide Tikosyn Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details Fluconazole Encorafenib Braftovi Increased encorafenib exposure, an increased risk of encorafenib-related adverse events and an increased risk of QT interval prolo... Details Fluconazole Entrectinib Rozlytrek Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details Fluconazole Glasdegib Daurismo Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details Fluconazole Granisetron Transdermal Patch Sancuso Increased granisetron exposure and an increased risk of QT interval prolongation Details Fluconazole Granisetron Injection Granisol Increased granisetron exposure and an increased risk of QT interval prolongation Details Fluconazole Ivabradine Corlanor Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details Fluconazole Ketoconazole Topical Extina® Foam Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details Fluconazole Lefamulin Xenleta Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details

Major

Fluconazole Acetaminophen And Codeine Capital® & Codeine Explained Increased codeine and morphine exposure Details Fluconazole Clindamycin ANTIROBE Explained Increased sensitive CYP3A4 substrates exposure Details Fluconazole Omeprazole Gastrobim Explained Increased omeprazole exposure Details Fluconazole Amitriptyline Elavil Explained Increased amitriptyline exposure, an increased risk of amitriptyline toxicity and an increased risk of cardiotoxicity (QT interval... Details Fluconazole Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Fluconazole Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Fluconazole Simvastatin Flolipid Explained Increased simvastatin exposure and an increased risk of myopathy and rhabdomyolysis Details Fluconazole Abrocitinib Cibinqo Explained Increased abrocitinib exposure and an increased active metabolite exposure Details Fluconazole Acalabrutinib Calquence Increased acalabrutinib exposure and increased risk of toxicity Details Fluconazole Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Fluconazole Apixaban Eliquis Explained Increased apixaban exposure and an increased risk for toxicity Details Fluconazole Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Fluconazole Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation Details Fluconazole Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Fluconazole Atogepant Qulipta Increased sensitive CYP3A4 substrates exposure Details Fluconazole Avapritinib Ayvakit Increased avapritinib exposure and an increased risk of the incidence and severity of adverse reactions Details Fluconazole Avatrombopag Doptelet Increased avatrombopag exposure Details Fluconazole Azathioprine Azasan An increased risk of hepatotoxicity Details Fluconazole Azithromycin AzaSite An increased risk of QT interval prolongation Details Fluconazole Atorvastatin Atorvaliq Increased atorvastatin exposure and an increased risk of myopathy and rhabdomyolysis Details Fluconazole Cariprazine Vraylar Explained Increased cariprazine and its major active metabolite (didesmethylcariprazine (DDCAR)) exposure Details Fluconazole Aficamten Increased aficamten exposure and an increased risk of aficamten-related adverse reaction Details Fluconazole Amlodipine Amvaz® Increased amLODIPine exposure and an increased risk of hypotension and edema Details Fluconazole Anagrelide Agrylin Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.