Fluconazole and Fluvastatin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Fluconazole
Fluvastatin
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased fluvastatin exposure and an increased risk of myopathy and rhabdomyolysis
Interaction Deep Dive
Avoid concomitant use of fluvastatin with fluconazole2. If unavoidable, do not exceed a fluvastatin dose of 20 mg twice daily in patients receiving fluconazole 1. Concomitant use of fluconazole (a moderate CYP2C9 and moderate CYP3A4 inhibitor) 3 with CYP2C9 and CYP3A4 substrates, such as fluvastatin, may increase fluvastatin exposure and increase the risk for toxicity 1. If coadministration is required, monitor creatine kinase (CK) levels and symptoms of myopathy and rhabdomyolysis. Discontinue fluvastatin use if significant CK elevations occur or if myopathy or rhabdomyolysis is diagnosed or suspected. Dose reduction of fluvastatin may be needed. Fluconazole enzyme inhibitory effects may persist for 4 to 5 days after discontinuation due to its long half-life 3. AUC increases up to 84% have been reported as a result of the interaction between fluvastatin and fluconazole. An individual patient using fluvastatin 80 mg daily may be exposed to considerable fluvastatin concentrations if treated with high doses of fluconazole 4.
Why it happens (mechanism)
Inhibition of CYP2C9-mediated metabolism of fluvastatin; inhibition of CYP3A4-mediated metabolism of fluvastatin by fluconazole
Literature reports
1 report — tap to read
a) Plasma fluvastatin concentrations were significantly increased by a 4-day pretreatment with fluconazole. In this randomized, double-blind, two-phase, crossover study, 12 healthy volunteers were observed to evaluate the effects of fluconazole on the plasma concentration of fluvastatin. The mean AUC of fluvastatin was increased by 84%, and the Cmax was increased by 44% with fluconazole. The mean half-life of fluvastatin was increased by 80% 42.
Common questions
Can I take Fluconazole and Fluvastatin together?
Increased fluvastatin exposure and an increased risk of myopathy and rhabdomyolysis Always confirm with your pharmacist or prescriber before making any change.
How serious is the Fluconazole and Fluvastatin interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Fluconazole or Fluvastatin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (4)
- Product Information: Fluvastatin sodium oral capsules, fluvastatin sodium oral capsules. Mylan Pharmaceuticals Inc (per DailyMed), Morgantown, WV, 2020. DailyMed
- Product Information: Lescol(R) XL oral extended release tablets, fluvastatin sodium oral extended release tablets. Sandoz, Inc.(per FDA), Princeton, NJ, 2023. DailyMed
- Product Information: DIFLUCAN(R) oral tablets, suspension, fluconazole oral tablets, suspension. Roerig (per FDA), New York, NY, 2023. DailyMed
- Kantola T, Backman J, Niemi M, et al: Effect of fluconazole on plasma fluvastatin and pravastatin concentrations. Eur J Clin Pharmacol 2000; 56:225-229. PubMed
Keep reading about Fluconazole
Keep reading about Fluvastatin
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