Terconazole
Terconazole is an azole antifungal used as a vaginal cream or vaginal suppository to treat vulvovaginal candidiasis, a vaginal yeast infection.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 14 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
Terconazole is a prescription azole antifungal, used as a vaginal cream or insert for three nights to treat a yeast infection (vulvovaginal candidiasis), and works by blocking the yeast from making ergosterol, a building block of its cell wall; on the market since the late 1980s and available as a generic, it is a prescription alternative to over-the-counter yeast creams. Most people tolerate it well; headache, period cramps, and genital burning or itching are what people notice most. Stop it and get help right away for signs of a serious allergic or skin reaction (trouble breathing, blistering or peeling skin), or for fever, chills or flu-like symptoms with the cream.
Clinical pearls
- Insert it at bedtime so it stays in place overnight, and finish all three nights even if itching eases after the first.
- It works only on Candida yeast, so a lab test (a KOH smear or culture) should confirm the diagnosis first.
- Birth control pills do not weaken terconazole, and the cream did not change hormone levels in women on low-dose pills.
- If you have reacted to another azole antifungal before, or symptoms return, get checked before using another course.
Patient information guide A plain-language walkthrough of Terconazole, written from its FDA label.
What Terconazole is used for
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Terconazole is used for one condition across its supported products.
- Terconazole vaginal cream: local treatment of vulvovaginal candidiasis (a vaginal yeast infection).
- Terconazole vaginal suppositories: local treatment of vulvovaginal candidiasis.
- Both work only for infections caused by Candida, so lab tests (KOH smears and/or cultures) should confirm the diagnosis.
How Terconazole works
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Terconazole is an azole antifungal. It blocks a fungal enzyme needed to turn lanosterol into ergosterol, which fungi need for their cell wall. As ergosterol is lost, the yeast cannot grow normally.
Human cells are less sensitive to this effect. Terconazole also does not affect the lactobacilli, the helpful bacteria normally found in the vagina.
Terconazole dosage
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Both forms are used in the vagina once a day at bedtime for three days in a row.
- Terconazole vaginal cream: one applicator full each night. Not for the mouth or eyes.
- Terconazole vaginal suppositories: one suppository each night. Menstruation does not reduce its effect.
Follow your prescriber's directions and the product label.
Dosing details from the FDA-approved label
From the Terconazole prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.
- Terconazole Vaginal Cream (0.8%)
- One applicator full (5 grams of cream containing 40 mg terconazole) administered intravaginally once daily at bedtime for three consecutive days
- Not for oral or ophthalmic use
- Terconazole Vaginal Suppository
- One suppository (80 mg terconazole) administered intravaginally once daily at bedtime for three consecutive days
- Before prescribing another course of therapy, the diagnosis should be reconfirmed by smears and/or cultures and other pathogens commonly associated with vulvovaginitis ruled out. The therapeutic effect is not affected by menstruation.
Read the label’s full dosing text
2 DOSAGE AND ADMINISTRATION The recommended dose is one applicator full of Terconazole Vaginal Cream (5 grams of cream containing 40 mg terconazole) administered intravaginally once daily at bedtime for three consecutive days. Terconazole Vaginal Cream is not for oral or ophthalmic use. • One full applicator (5 grams) of Terconazole Vaginal Cream administered intravaginally once daily at bedtime for three (3) consecutive days. ( 2 ) • Not for oral or ophthalmic use. ( 2 )
Read the full Dosage and Administration section on DailyMed →
Terconazole side effects
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The most common side effects are:
Common side effects
- Headache
- Painful periods (dysmenorrhea)
- Genital burning and itching
- Abdominal pain
- Fever (less common)
When to get medical help
- Stop the cream and call your doctor if you develop skin irritation, fever, chills or flu-like symptoms.
- Stop the suppositories and get emergency help for signs of a severe allergic reaction (anaphylaxis).
- Stop the suppositories and get urgent help for a severe skin reaction called toxic epidermal necrolysis (widespread painful skin peeling and blistering).
- Call your doctor if symptoms do not improve before using another course.
Terconazole warnings and precautions
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- Anaphylaxis and toxic epidermal necrolysis have been reported. Stop the suppositories if either occurs.
- With the cream, stop and do not retreat if skin irritation, fever, chills or flu-like symptoms occur.
- Before another course, the diagnosis should be reconfirmed and other causes of vaginal infection ruled out.
- Patients with a history of allergy to azole antifungals should be monitored.
Terconazole interactions
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The label notes little in the way of interactions.
- Birth control pills: do not change how well terconazole works.
- Hormone levels: estradiol and progesterone did not differ significantly when the vaginal cream was used with a low-dose birth control pill.
Interactions listed in the FDA-approved label
From the Terconazole prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.
- Oral contraceptives: The therapeutic effect of terconazole is not affected by oral contraceptive usage; levels of estradiol and progesterone did not differ significantly when 0.8% terconazole vaginal cream was administered to healthy female volunteers established on a low dose oral contraceptive.
Read the label’s full interactions text
Drug Interactions - The therapeutic effect of terconazole is not affected by oral contraceptive usage. The levels of estradiol and progesterone did not differ significantly when 0.8% terconazole vaginal cream was administered to healthy female volunteers established on a low dose oral contraceptive.
Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.
Before taking Terconazole
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- Do not use the cream if you are allergic to terconazole or any of its ingredients.
- Tell your doctor about any past allergy to azole antifungals.
- Pregnancy: no human data on the cream are available to assess risk.
- Breastfeeding: no data on milk transfer. Weigh benefits and risks with your doctor.
- Children: safety and effectiveness of the cream have not been established.
- Adults 65 and older: not enough studied to know if response differs.
Terconazole overdose
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If the cream or suppository is swallowed, supportive and symptom-based care is recommended. If the cream gets in the eyes, rinse with clean water or saline and seek medical attention if symptoms persist.
What Terconazole does in the body
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Terconazole shows antifungal activity in the lab against Candida albicans and other Candida species. It does not affect most of the beneficial lactobacilli normally found in the vagina.
How your body processes Terconazole
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Most of the drug stays in the vagina after use. Roughly 10% is absorbed into the bloodstream over 7 days, with blood levels peaking about 5 to 10 hours after use. Absorbed terconazole is extensively broken down by the body and is about 95% bound to proteins in the blood. Its half-life is about 6.4 to 8.5 hours, and levels do not build up meaningfully with repeated use.
How to store Terconazole
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Store at 20° to 25°C (68° to 77°F) .
Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
Supplements & herbs that interact with Terconazole
20 supplements and herbal products have documented interactions with Terconazole in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.
- Major · 1
- Moderate · 7
- Minor · 12
Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.
Terconazole: pharmacist answers to common questions
Quick, plain-English answers to the questions patients ask most about Terconazole — the kind of thing our pharmacy team would talk through with you at the counter.
What is terconazole for?
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How do I use it?
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What side effects should I expect?
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When should I stop and call someone?
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Can I use it if I take birth control pills?
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Is it safe in pregnancy or while breastfeeding?
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Is Terconazole available over the counter?
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When was Terconazole first available?
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Who makes Terconazole?
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Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
More about Terconazole on HelloPharmacist
Terconazole forms and strengths (how it comes)
Terconazole is available in 2 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Terconazole inactive ingredients by manufacturer.
Vaginal cream or gel
How this form is used
- Terconazole vaginal cream is used for the local treatment of vulvovaginal candidiasis.
- Terconazole vaginal cream is given as one full applicator inserted into the vagina once daily at bedtime for three days in a row.
- Terconazole vaginal cream is not for oral or ophthalmic (eye) use.
- If Terconazole vaginal cream gets in the eyes, rinse with clean water or saline and seek medical care if symptoms persist.
Vaginal insert
How this form is used
- Terconazole vaginal suppositories are used for the local treatment of vulvovaginal candidiasis.
- Terconazole vaginal suppositories are given as one suppository inserted into the vagina once daily at bedtime for three days in a row.
- Terconazole vaginal suppositories work even during menstruation.
Terconazole on the U.S. market: products, makers and brands
How Terconazole appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
6 companies list 12 Terconazole product records with the FDA, mostly as vaginal cream or gel, vaginal insert; the earliest marketing or approval year on record is 1987. Brand names on the directory include Terconazole Vaginal Cream 0.8%; the rest are generics.
FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
Also listed with the FDA, not a patient dose form: Powder (3) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
How widely Terconazole is used (Medicaid data)
A general measure of how commonly Terconazole is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Terconazole is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Terconazole prescribed? Of the 1,601 medications we measure, Terconazole ranks #363 by Medicaid prescriptions — more than 77% of them.
Utilization by Terconazole product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
terconazole 4 MG/ML Vaginal Cream Most dispensed
Summed across the 2 of 5 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 313226
terconazole 8 MG/ML Vaginal Cream
Summed across the 2 of 6 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 313227
terconazole 80 MG Vaginal Insert
Summed across the 2 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 198245
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Terconazole, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 6 of 15 listed Terconazole NDCs with Medicaid activity.
Compare Terconazole products
A representative set of FDA-listed product records for Terconazole — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Vaginal cream or gel | ||||
| 4 mg/g | Vaginal | A-S Medication Solutions × 2 listings | ANDA | View NDC → |
| 8 mg/g | Vaginal | A-S Medication Solutions | NDA | View NDC → |
| 8 mg/g | Vaginal | A-S Medication Solutions | ANDA | View NDC → |
| 4 mg/g | Vaginal | E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC | ANDA | View NDC → |
| 8 mg/g | Vaginal | E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC | NDA | View NDC → |
| 8 mg/g | Vaginal | NuCare Pharmaceuticals,Inc. | ANDA | View NDC → |
| 4 mg/g | Vaginal | Sun Pharmaceutical Industries, Inc. | ANDA | View NDC → |
| 8 mg/g | Vaginal | Sun Pharmaceutical Industries, Inc. | ANDA | View NDC → |
| 💊Vaginal insert | ||||
| 80 mg | Vaginal | Cosette Pharmaceuticals, Inc. | ANDA | View NDC → |
| 80 mg | Vaginal | Padagis Israel Pharmaceuticals Ltd | ANDA | View NDC → |
| 80 mg | Vaginal | Sun Pharmaceutical Industries, Inc. | ANDA | View NDC → |
Showing 12 of 12 products — FDA National Drug Code Directory. See every product, package size and price: browse all 12 Terconazole NDCs →
Terconazole side effects reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Terconazole — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Terconazole in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
Terconazole FDA approval history
How Terconazole went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
Terconazole recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
The FDA’s enforcement reports list one Terconazole recall since July 2021. It is no longer listed as ongoing. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.
- Terconazole Vaginal Suppositories, 80 mg, 3 Suppositories with Vaginal Applicator, Rx only, Manufactured by: Cosette Pharmaceuticals, Inc., 111 Coolidge Street, South Plainfield, NJ 07080. NDC: 0713-… Lots: Batch 1014228A FDA record D-0198-2024 →
Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 37806 2 dose forms · 3 strengths
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Dose form (SCDF) Vaginal Cream RxCUI 379487In current FDA listings -
Dose form (SCDF) Vaginal Insert RxCUI 2109039In current FDA listingsClinical drug / strength (SCD) 80 MGRxCUI 198245
Look up RxCUI 37806 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
Terconazole supply and shortage status
Whether Terconazole is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
💵 What Terconazole costs pharmacies (NADAC benchmark)
The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.
| Form | Strength | Pharmacy acquisition benchmark | |
|---|---|---|---|
| Cream · Vaginal | 8 mg/g | $0.987 per gram | NDC details & price history |
| Cream · Vaginal | 4 mg/g | $0.552 per gram | NDC details & price history |
| Suppository · Vaginal | 80 mg | $18.62 each | NDC details & price history |
Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.
Terconazole brand names
Terconazole is sold under one brand name in the FDA directory — Terconazole Vaginal Cream 0.8%. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.
Who makes Terconazole: manufacturers and labelers
6 companies list Terconazole products with the FDA. By number of product records, the largest are A-S Medication Solutions, Sun Pharmaceutical Industries, Inc., E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.
Terconazole drug class (RxNorm)
Terconazole belongs to the Azole Antifungal class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
Sources for this Terconazole page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How this page is built
HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. E. Fougera & Co. a division of Fougera Pharmaceuticals Inc. is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →