Calcium Carbonate

Generic name: Pronounced as (kal' see um) (kar' bon ate)
Brand names
  • Alka-Mints®
  • Calcid®
  • Calel-D®
  • Caltrate 600®
  • Chooz®
  • Miralac®
  • Os-Cal 500®
  • Rolaids®
  • Titralac®
  • Tums®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 09/15/2015

Calcium carbonate is a dietary supplement used when the amount of calcium taken in the diet is not enough. Calcium is needed by the body for healthy bones, muscles, nervous system, and heart. Calcium carbonate also is used as an antacid to relieve heartburn, acid indigestion, and upset stomach. It is available with or without a prescription.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Calcium carbonate comes as a tablet, chewable tablet, capsule, and liquid to take by mouth. It is usually taken three or four times a day. Follow the directions on your prescription or package label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take calcium carbonate exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. When using this medicine as a dietary supplement, take it with food or following meals.

Chewable tablets should be chewed thoroughly before being swallowed; do not swallow them whole. Drink a full glass of water after taking either the regular or chewable tablets or capsules. Some liquid forms of calcium carbonate must be shaken well before use.

Do not take calcium carbonate as an antacid for more than 2 weeks unless your doctor tells you to.

Before taking calcium carbonate,

  • tell your doctor and pharmacist if you are allergic to calcium carbonate or any other drugs.

  • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially digoxin (Lanoxin), etidronate (Didronel), phenytoin (Dilantin), tetracycline (Sumycin), and vitamins. Do not take calcium carbonate within 1-2 hours of taking other medicines. Calcium may decrease the effectiveness of the other medicine.

  • tell your doctor if you have or have ever had kidney disease or stomach conditions.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking calcium carbonate, call your doctor.

If you are taking calcium carbonate on a regular schedule, take the missed dose as soon you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Calcium carbonate may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • upset stomach

    • vomiting

    • stomach pain

    • belching

    • constipation

    • dry mouth

    • increased urination

    • loss of appetite

    • metallic taste

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

If this medicine has been prescribed for you, keep all appointments with your doctor so that your response to calcium carbonate can be checked. Do not let anyone else take your medicine.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Gas-X® with Maalox® (containing Calcium Carbonate, Simethicone)
  • Rolaids® Plus Gas Relief (containing Calcium Carbonate, Simethicone)
  • Titralac® Plus (containing Calcium Carbonate, Simethicone)

Drug Interaction
Moxifloxacin Moxifloxacin Calcium carbonate can cause a decrease in the absorption of Moxifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Delavirdine Delavirdine Calcium carbonate can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Alendronate Alendronate The serum concentration of Alendronic acid can be decreased when it is combined with Calcium carbonate.
Bisacodyl Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Calcium carbonate.
Mycophenolate Mycophenolate Calcium carbonate can cause a decrease in the absorption of Mycophenolic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Penbutolol Penbutolol The therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium carbonate.
Polyethylene glycol-electrolyte solution (PEG-ES) Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Calcium carbonate.
Prednisone Prednisone The bioavailability of Prednisone can be decreased when combined with Calcium carbonate.
Tiludronate Tiludronate The serum concentration of Etidronic acid can be decreased when it is combined with Calcium carbonate.
Triamcinolone Triamcinolone The bioavailability of Triamcinolone can be decreased when combined with Calcium carbonate.
Doxycycline Injection Doxycycline Injection The serum concentration of Doxycycline can be decreased when it is combined with Calcium carbonate.
Levofloxacin Injection Levofloxacin Injection Calcium carbonate can cause a decrease in the absorption of Levofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methylprednisolone Injection Methylprednisolone Injection The bioavailability of Methylprednisolone can be decreased when combined with Calcium carbonate.
Pamidronate Injection Pamidronate Injection The serum concentration of Pamidronic acid can be decreased when it is combined with Calcium carbonate.
Altretamine Altretamine The serum concentration of Amphetamine can be increased when it is combined with Calcium carbonate.
Cefuroxime Cefuroxime The serum concentration of Cefuroxime can be decreased when it is combined with Calcium carbonate.
Enoxaparin Injection Enoxaparin Injection The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Enoxaparin.
Hydroxychloroquine Hydroxychloroquine Calcium carbonate can cause a decrease in the absorption of Hydroxychloroquine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Risedronate Risedronate The serum concentration of Risedronic acid can be decreased when it is combined with Calcium carbonate.
Pentosan Polysulfate Pentosan Polysulfate The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Pentosan polysulfate.
Dexmethylphenidate Dexmethylphenidate Calcium carbonate can cause a decrease in the absorption of Dexmethylphenidate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Atazanavir Atazanavir Calcium carbonate can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Polyethylene Glycol 3350 Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Calcium carbonate.
Rosuvastatin Rosuvastatin Calcium carbonate can cause a decrease in the absorption of Rosuvastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Memantine Memantine Calcium carbonate may decrease the excretion rate of Memantine which could result in a higher serum level.
Fosamprenavir Fosamprenavir Calcium carbonate can cause a decrease in the absorption of Fosamprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gemifloxacin Gemifloxacin Calcium carbonate can cause a decrease in the absorption of Gemifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Erlotinib Erlotinib Calcium carbonate can cause a decrease in the absorption of Erlotinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Voriconazole Voriconazole Calcium carbonate can cause a decrease in the absorption of Voriconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zoledronic Acid Injection Zoledronic Acid Injection The serum concentration of Zoledronic acid can be decreased when it is combined with Calcium carbonate.
Dextroamphetamine Dextroamphetamine The serum concentration of Amphetamine can be increased when it is combined with Calcium carbonate.
Ibandronate Ibandronate The serum concentration of Ibandronate can be decreased when it is combined with Calcium carbonate.
Tipranavir Tipranavir Calcium carbonate can cause a decrease in the absorption of Tipranavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gefitinib Gefitinib Calcium carbonate can cause a decrease in the absorption of Gefitinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Posaconazole Posaconazole Calcium carbonate can cause a decrease in the absorption of Posaconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Darunavir Darunavir Calcium carbonate can cause a decrease in the absorption of Darunavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lisdexamfetamine Lisdexamfetamine The serum concentration of Lisdexamfetamine can be increased when it is combined with Calcium carbonate.
Dasatinib Dasatinib Calcium carbonate can cause a decrease in the absorption of Dasatinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Raltegravir Raltegravir The serum concentration of Raltegravir can be decreased when it is combined with Calcium carbonate.
Budesonide Budesonide The bioavailability of Budesonide can be decreased when combined with Calcium carbonate.
Aminocaproic Acid Aminocaproic Acid The risk or severity of adverse effects can be increased when Aminocaproic acid is combined with Calcium carbonate.
Nebivolol Nebivolol The therapeutic efficacy of Nebivolol can be decreased when used in combination with Calcium carbonate.
Estramustine Estramustine Calcium carbonate can cause a decrease in the absorption of Estramustine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Eltrombopag Eltrombopag The serum concentration of Eltrombopag can be decreased when it is combined with Calcium carbonate.
Sodium Phosphate Sodium Phosphate Calcium carbonate can cause a decrease in the absorption of Sodium phosphate, monobasic resulting in a reduced serum concentration and potentially a decrease in efficacy.
Betaxolol Betaxolol The therapeutic efficacy of Betaxolol can be decreased when used in combination with Calcium carbonate.
Prasugrel Prasugrel The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Prasugrel.
Pazopanib Pazopanib Calcium carbonate can cause a decrease in the absorption of Pazopanib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dabigatran Dabigatran The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Dabigatran.
Acetaminophen Injection Acetaminophen Injection Calcium carbonate can cause a decrease in the absorption of Acetaminophen resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rilpivirine Rilpivirine Calcium carbonate can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rivaroxaban Rivaroxaban The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Rivaroxaban.
Ticagrelor Ticagrelor The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Ticagrelor.
Deferiprone Deferiprone The serum concentration of Deferiprone can be decreased when it is combined with Calcium carbonate.
Tranexamic Acid Tranexamic Acid Tranexamic acid may increase the thrombogenic activities of Calcium carbonate.
Fondaparinux Injection Fondaparinux Injection The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Fondaparinux.
Iloprost Iloprost The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Iloprost.
Bosutinib Bosutinib Calcium carbonate can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Apixaban Apixaban The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Apixaban.
Dabrafenib Dabrafenib Calcium carbonate can cause a decrease in the absorption of Dabrafenib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dolutegravir Dolutegravir The serum concentration of Dolutegravir can be decreased when it is combined with Calcium carbonate.
Iron Sucrose Injection Iron Sucrose Injection Calcium carbonate can cause a decrease in the absorption of Iron sucrose resulting in a reduced serum concentration and potentially a decrease in efficacy.
Iron Dextran Injection Iron Dextran Injection Calcium carbonate can cause a decrease in the absorption of Iron Dextran resulting in a reduced serum concentration and potentially a decrease in efficacy.
Vorapaxar Vorapaxar The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Vorapaxar.
Edoxaban Edoxaban The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Edoxaban.
Methamphetamine Methamphetamine The serum concentration of Metamfetamine can be increased when it is combined with Calcium carbonate.
Riociguat Riociguat Calcium carbonate can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Palbociclib Palbociclib The absorption of Palbociclib can be decreased when combined with Calcium carbonate.
Isavuconazonium Injection Isavuconazonium Injection Calcium carbonate can cause a decrease in the absorption of Isavuconazonium resulting in a reduced serum concentration and potentially a decrease in efficacy.
Prednisolone Prednisolone The bioavailability of Prednisolone can be decreased when combined with Calcium carbonate.
Dexamethasone Injection Dexamethasone Injection The bioavailability of Dexamethasone can be decreased when combined with Calcium carbonate.
Defibrotide Injection Defibrotide Injection The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Defibrotide.
Calcifediol Calcifediol The risk or severity of adverse effects can be increased when Calcium carbonate is combined with Calcifediol.
Ergocalciferol Ergocalciferol The risk or severity of adverse effects can be increased when Calcium carbonate is combined with Ergocalciferol.
Doxercalciferol Doxercalciferol The risk or severity of adverse effects can be increased when Calcium carbonate is combined with Doxercalciferol.
Deflazacort Deflazacort The bioavailability of Deflazacort can be decreased when combined with Calcium carbonate.
Delafloxacin Delafloxacin Calcium carbonate can cause a decrease in the absorption of Delafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Betrixaban Betrixaban The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Betrixaban.
Penicillamine Penicillamine Calcium carbonate can cause a decrease in the absorption of Penicillamine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Omadacycline Omadacycline The serum concentration of Omadacycline can be decreased when it is combined with Calcium carbonate.
Sarecycline Sarecycline The serum concentration of Sarecycline can be decreased when it is combined with Calcium carbonate.
Magnesium Citrate Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Calcium carbonate.
Erdafitinib Erdafitinib The risk or severity of adverse effects can be increased when Calcium carbonate is combined with Erdafitinib.
Calcium Acetate Calcium Acetate The risk or severity of adverse effects can be increased when Calcium carbonate is combined with Calcium acetate.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Calcium carbonate.
Octreotide Octreotide Calcium carbonate can cause a decrease in the absorption of Octreotide resulting in a reduced serum concentration and potentially a decrease in efficacy.
Naproxen Naproxen Naproxen can cause a decrease in the absorption of Calcium carbonate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Diethylpropion Diethylpropion The serum concentration of Diethylpropion can be increased when it is combined with Calcium carbonate.
Chlorpromazine Chlorpromazine Calcium carbonate can cause a decrease in the absorption of Chlorpromazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tetracycline Tetracycline The serum concentration of Tetracycline can be decreased when it is combined with Calcium carbonate.
Minocycline Minocycline The serum concentration of Minocycline can be decreased when it is combined with Calcium carbonate.
Demeclocycline Demeclocycline The serum concentration of Demeclocycline can be decreased when it is combined with Calcium carbonate.
Prochlorperazine Prochlorperazine Calcium carbonate can cause a decrease in the absorption of Prochlorperazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Thioridazine Thioridazine Calcium carbonate can cause a decrease in the absorption of Thioridazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Trifluoperazine Trifluoperazine Calcium carbonate can cause a decrease in the absorption of Trifluoperazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Perphenazine Perphenazine Calcium carbonate can cause a decrease in the absorption of Perphenazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fluphenazine Fluphenazine Calcium carbonate can cause a decrease in the absorption of Fluphenazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Phentermine Phentermine The serum concentration of Phentermine can be increased when it is combined with Calcium carbonate.
Methylphenidate Methylphenidate Calcium carbonate can cause an increase in the absorption of Methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.
Hydrocortisone Hydrocortisone The bioavailability of Hydrocortisone can be decreased when combined with Calcium carbonate.
Warfarin Warfarin The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Warfarin.
Promethazine Promethazine Calcium carbonate can cause a decrease in the absorption of Promethazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methenamine Methenamine The therapeutic efficacy of Methenamine can be decreased when used in combination with Calcium carbonate.
Digoxin Digoxin Calcium carbonate may increase the arrhythmogenic activities of Digoxin.
Chloroquine Chloroquine Calcium carbonate can cause a decrease in the absorption of Chloroquine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcitriol Calcitriol The risk or severity of adverse effects can be increased when Calcium carbonate is combined with Calcitriol.
Lactulose Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Calcium carbonate.
Chlorothiazide Chlorothiazide Chlorothiazide may decrease the excretion rate of Calcium carbonate which could result in a higher serum level.
Chlorthalidone Chlorthalidone Chlorthalidone may decrease the excretion rate of Calcium carbonate which could result in a higher serum level.
Metolazone Metolazone Metolazone may decrease the excretion rate of Calcium carbonate which could result in a higher serum level.
Quinidine Quinidine Calcium carbonate may decrease the excretion rate of Quinidine which could result in a higher serum level.
Rifampin Rifampin Calcium carbonate can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Levothyroxine Levothyroxine Calcium carbonate can cause a decrease in the absorption of Levothyroxine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Liothyronine Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Calcium carbonate.
Methyclothiazide Methyclothiazide Methyclothiazide may decrease the excretion rate of Calcium carbonate which could result in a higher serum level.
Hydrochlorothiazide Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Calcium carbonate which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The therapeutic efficacy of Propranolol can be decreased when used in combination with Calcium carbonate.
Pseudoephedrine Pseudoephedrine The serum concentration of Pseudoephedrine can be increased when it is combined with Calcium carbonate.
Nadolol Nadolol The therapeutic efficacy of Nadolol can be decreased when used in combination with Calcium carbonate.
Allopurinol Allopurinol The therapeutic efficacy of Allopurinol can be decreased when used in combination with Calcium carbonate.
Ketoconazole Ketoconazole Calcium carbonate can cause a decrease in the absorption of Ketoconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Captopril Captopril Calcium carbonate can cause a decrease in the absorption of Captopril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dipyridamole Dipyridamole The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Dipyridamole.
Metoprolol Metoprolol The therapeutic efficacy of Metoprolol can be decreased when used in combination with Calcium carbonate.
Hyoscyamine Hyoscyamine Calcium carbonate can cause a decrease in the absorption of Hyoscyamine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Timolol Timolol The therapeutic efficacy of Timolol can be decreased when used in combination with Calcium carbonate.
Atenolol Atenolol The therapeutic efficacy of Atenolol can be decreased when used in combination with Calcium carbonate.
Pindolol Pindolol The therapeutic efficacy of Pindolol can be decreased when used in combination with Calcium carbonate.
Indapamide Indapamide Indapamide may decrease the excretion rate of Calcium carbonate which could result in a higher serum level.
Labetalol Labetalol The therapeutic efficacy of Labetalol can be decreased when used in combination with Calcium carbonate.
Ciprofloxacin Ciprofloxacin Calcium carbonate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Mesalamine Mesalamine Calcium carbonate can cause a decrease in the absorption of Mesalazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ofloxacin Ofloxacin Calcium carbonate can cause a decrease in the absorption of Ofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Itraconazole Itraconazole Calcium carbonate can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sotalol Sotalol The therapeutic efficacy of Sotalol can be decreased when used in combination with Calcium carbonate.
Bisoprolol Bisoprolol The therapeutic efficacy of Bisoprolol can be decreased when used in combination with Calcium carbonate.
Saquinavir Saquinavir Calcium carbonate can cause a decrease in the absorption of Saquinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dalteparin Injection Dalteparin Injection The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Dalteparin.
Indinavir Indinavir Calcium carbonate can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ritonavir Ritonavir Calcium carbonate can cause a decrease in the absorption of Ritonavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nelfinavir Nelfinavir Calcium carbonate can cause a decrease in the absorption of Nelfinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Carvedilol Carvedilol The therapeutic efficacy of Carvedilol can be decreased when used in combination with Calcium carbonate.
Propafenone Propafenone The therapeutic efficacy of Propafenone can be decreased when used in combination with Calcium carbonate.
Cefpodoxime Cefpodoxime The serum concentration of Cefpodoxime can be decreased when it is combined with Calcium carbonate.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists