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Nabumetone

Nabumetone is a prescription NSAID (non-aspirin anti-inflammatory pain reliever) used to relieve the signs and symptoms of osteoarthritis and rheumatoid arthritis.

Brand names RelafenRelafen Ds
Drug class Nonsteroidal Anti-inflammatory Drug
Rx Form 1
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 55 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 7, 2026
Nabumetone at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Nabumetone (Relafen) is a prescription NSAID (non-aspirin anti-inflammatory) for osteoarthritis and rheumatoid arthritis. It is a familiar arthritis option, on the market since about 1991 and available as a generic, and your liver turns it into an active form that blocks prostaglandins, the chemicals behind joint pain and inflammation. Most people tolerate it well, and the usual complaints are indigestion, stomach pain, diarrhea or constipation. Like every NSAID, it carries a boxed warning for heart attack, stroke and stomach or intestinal bleeding that can come without warning, so get help right away for chest pain, black or bloody stools, or severe stomach pain.

Clinical pearls

  • It works once daily or split into two doses, with or without food, and taking it with food may ease stomach upset.
  • It can weaken ACE inhibitors, ARBs and water pills like furosemide, so check your blood pressure and watch for ankle swelling.
  • Combining it with warfarin, another blood thinner, a steroid like prednisone, or aspirin raises the chance of stomach bleeding.
  • Use the lowest dose for the shortest time that controls your arthritis, since heart risk can climb the longer you take it.
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

Nabumetone and other NSAIDs can raise the risk of serious, sometimes fatal, heart attack and stroke. The risk may grow the longer you take it. People with heart disease or heart risk factors may be at greater risk.

It must not be used for pain around coronary artery bypass graft (CABG) surgery.

NSAIDs can also cause serious bleeding, ulcers, or tears in the stomach or intestines, which can be fatal. This can happen at any time and without warning symptoms. Older adults are at greater risk. Watch for chest pain, shortness of breath, weakness, black or bloody stools, or severe stomach pain, and get medical help right away.

Read the full warning on DailyMed →
How you get itPrescription only
Comes asTablet
Earliest FDA record1991
Companies listing it with the FDA26
FDA label last updatedAug 6, 2025
FDA’s strongest warning (boxed)Yes, read the warning

Patient information guide A plain-language walkthrough of Nabumetone, written from its FDA label.

What Nabumetone is used for

▾

Nabumetone is used for two types of arthritis:

  • Osteoarthritis: relief of signs and symptoms.
  • Rheumatoid arthritis: relief of signs and symptoms.

Both Relafen DS and the generic nabumetone tablets list these uses.

How Nabumetone works

▾

Nabumetone is a prodrug, which means it is changed in the liver into its active form, 6MNA. 6MNA blocks the making of prostaglandins, chemicals involved in inflammation and pain.

The exact way NSAIDs work is not fully known, but blocking prostaglandins is thought to play a role in the anti-inflammatory effect.

Nabumetone dosage

▾

Nabumetone is taken by mouth as a tablet, once a day or divided into two doses. You can take it with or without food. Your prescriber will adjust the dose based on your response, aiming for the lowest effective dose.

  • People under 50 kg may be less likely to need higher doses.
  • Follow your prescriber's directions and the pharmacy label.

Dosing details from the FDA-approved label

From the Nabumetone prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Osteoarthritis and Rheumatoid Arthritis
    • The recommended starting dose is 1,000 mg taken as a single dose with or without food
    • Some patients may obtain more symptomatic relief from 1,500 mg to 2,000 mg per day
    • Can be given in either a single or twice-daily dose
    • Maximum: Dosages greater than 2,000 mg per day have not been studied.
    • Patients weighing under 50 kg may be less likely to require dosages beyond 1,000 mg; use the lowest effective dose for chronic treatment
Read the label’s full dosing text

DOSAGE AND ADMINISTRATION Carefully consider the potential benefits and risks of nabumetone tablets and other treatment options before deciding to use nabumetone tablets. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS ). After observing the response to initial therapy with nabumetone tablets, the dose and frequency should be adjusted to suit an individual patient's needs. Osteoarthritis and Rheumatoid Arthritis The recommended starting dose is 1,000 mg taken as a single dose with or without food. Some patients may obtain more symptomatic relief from 1,500 mg to 2,000 mg per day. Nabumetone tablets can be given in either a single or twice-daily dose. Dosages greater than 2,000 mg per day have not been studied. The lowest effective dose should be used for chronic treatment (see WARNINGS , Renal Effects ). Patients weighing under 50 kg may be less likely to require dosages beyond 1,000 mg; therefore, after observing the response to initial therapy, the dose should be adjusted to meet individual patients’ requirements.

Read the full Dosage and Administration section on DailyMed →

Nabumetone side effects

▾

The most common side effects involve the digestive system:

Common side effects

  • Diarrhea
  • Indigestion (dyspepsia)
  • Stomach pain
  • Constipation
  • Gas
  • Nausea
  • Headache or dizziness
  • Swelling (edema), rash or itching, ringing in the ears

When to get medical help

  • Chest pain, shortness of breath, weakness on one side, or slurred speech can signal a heart attack or stroke. Get emergency help.
  • Black or bloody stools, vomiting blood, or severe stomach pain can signal stomach or intestinal bleeding, an ulcer, or a perforation. These can happen without warning.
  • Stop the medicine and call right away for any skin rash, blisters, or other sign of an allergic reaction.
  • Fever, rash, swollen glands, or facial swelling can signal a rare severe reaction called DRESS. Stop the medicine and get evaluated right away.
  • Swelling, rapid weight gain, or worsening heart failure symptoms need prompt attention.
  • Yellowing of the skin or eyes can signal a liver problem. Call your doctor.
  • Get emergency help for signs of a severe allergic reaction, such as trouble breathing or swelling of the face or throat.

Nabumetone warnings and precautions

▾
  • Heart attack and stroke risk: This risk may begin within the first weeks and is higher at higher doses.
  • Stomach bleeding and ulcers: They can occur without warning. The risk is higher with a history of ulcers, older age, smoking, alcohol, steroids, or blood thinners.
  • Blood pressure and heart failure: NSAIDs can raise blood pressure and cause fluid retention.
  • Kidney problems: Long-term use can harm the kidneys.
  • Serious skin and allergic reactions: These include DRESS, Stevens-Johnson syndrome and anaphylaxis.

Nabumetone interactions

▾

Several medicines can interact with nabumetone:

  • Aspirin: more side effects, so generally not recommended together.
  • Warfarin: higher risk of serious bleeding.
  • ACE inhibitors: may weaken the blood pressure effect.
  • Diuretics: may reduce their effect and strain the kidneys.
  • Lithium: levels can rise.
  • Methotrexate: toxicity may increase.

Interactions listed in the FDA-approved label

From the Nabumetone prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • ACE-inhibitors: NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. Give consideration to this interaction in patients taking NSAIDs concomitantly with ACE-inhibitors.
  • Aspirin: When administered with aspirin, nabumetone's protein binding is reduced, although the clearance of free nabumetone is not altered; clinical significance is not known. Concomitant administration is not generally recommended because of the potential of increased adverse effects.
  • Diuretics (furosemide and thiazides): Nabumetone can reduce the natriuretic effect of furosemide and thiazides in some patients, attributed to inhibition of renal prostaglandin synthesis. Observe the patient closely for signs of renal failure, as well as to assure diuretic efficacy.
  • Lithium: NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance; mean minimum lithium concentration increased 15% and renal clearance decreased by approximately 20%. When administered concurrently, observe subjects carefully for signs of lithium toxicity.
  • Methotrexate: NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices, which may indicate they could enhance the toxicity of methotrexate. Use caution when NSAIDs are administered concomitantly with methotrexate.
  • Warfarin: The effects of warfarin and NSAIDs on GI bleeding are synergistic, so users of both drugs together have a higher risk of serious GI bleeding than users of either drug alone; 6MNA may displace other protein-bound drugs from their binding site in vitro. Caution should be exercised when administering nabumetone with warfarin since interactions have been seen with other NSAIDs.
  • Aluminum-containing antacid: Concomitant administration had no significant effect on the bioavailability of 6MNA.
  • Food or milk: When administered with food or milk, there is more rapid absorption; however, the total amount of 6MNA in the plasma is unchanged.
Read the label’s full interactions text

Drug Interactions: ACE-inhibitors: Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors. Aspirin: When nabumetone tablets are administered with aspirin, its protein binding is reduced, although the clearance of free nabumetone is not altered. The clinical significance of this interaction is not known; however, as with other NSAIDs, concomitant administration of nabumetone tablets and aspirin is not generally recommended because of the potential of increased adverse effects. Diuretics: Clinical studies, as well as post marketing observations, have shown that nabumetone can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with NSAIDs, the patient should be observed closely for signs of renal failure (see WARNINGS, Renal Effects ), as well as to assure diuretic efficacy. Lithium: NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance. The mean minimum lithium concentration increased 15% and the renal clearance was decreased by approximately 20%. These effects have been attributed to inhibition of renal prostaglandin synthesis by the NSAID. Thus, when NSAIDs and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity. Methotrexate: NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices. This may indicate that they could enhance the toxicity of methotrexate. Caution should be used when NSAIDs are administered concomitantly with methotrexate. Warfarin: The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.

Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

Before taking Nabumetone

▾
  • Do not use it if allergic to nabumetone or after aspirin/NSAID-triggered asthma, hives, or allergic reactions.
  • Do not use it for pain around CABG surgery.
  • Use caution with heart disease, high blood pressure, heart failure, or a recent heart attack.
  • Use caution with a history of ulcers or stomach bleeding.
  • Kidney disease: not recommended in advanced disease, and moderate impairment may need a dose change.
  • Pregnancy: avoid at about 30 weeks and later. Limit use between about 20 and 30 weeks.
  • Older adults face higher risks.

Nabumetone overdose

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Overdose symptoms can include drowsiness, lethargy, nausea, vomiting and upper stomach pain, and these usually improve with supportive care. Stomach bleeding can occur, and rarely high blood pressure, kidney failure, slowed breathing or coma. There is no specific antidote, so seek emergency help or call poison control right away.

What Nabumetone does in the body

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Nabumetone has anti-inflammatory, pain-relieving and fever-reducing effects. In one-week studies in healthy volunteers, it had little effect on platelet clumping and no effect on bleeding time, unlike naproxen.

How your body processes Nabumetone

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Nabumetone is well absorbed from the gut and quickly converted in the liver to its active form, 6MNA. Food speeds up absorption but does not change how much is absorbed. The half-life of 6MNA is roughly 22 to 30 hours, which supports once-daily dosing. It is eliminated mostly in the urine, with some in the feces.

How to store Nabumetone

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Store at 20° to 25°C (68° to 77°F) . Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

52

Supplements & herbs that interact with Nabumetone

52 supplements and herbal products have documented interactions with Nabumetone in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 5
  • Moderate · 35
  • Minor · 12
Every supplement checked against Nabumetone — ranked by severity The full interaction hub: 5 major · 35 moderate · 12 minor · every one linked to its full report. Check Nabumetone against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

1

Nutrient depletion considerations

Nabumetone has been associated with lower levels of 1 nutrient in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

See the full Nabumetone nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

Nabumetone: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Nabumetone — the kind of thing our pharmacy team would talk through with you at the counter.

What is nabumetone for?

▾
It relieves the pain and stiffness of osteoarthritis and rheumatoid arthritis. It's an NSAID, so it works on inflammation as well as pain.

How should I take it?

▾
Take it by mouth once a day or split into two doses, with or without food. Your prescriber will adjust it for you, and the goal is the lowest dose that works for the shortest time. Follow the directions on your pharmacy label.

What side effects should I expect?

▾
Stomach upset is the most common issue, including diarrhea, indigestion, stomach pain, gas and constipation. Some people get headaches, dizziness, rash, swelling, or ringing in the ears. Call your doctor if side effects bother you or don't go away.

When should I call my doctor or get emergency help?

▾
Get help right away for chest pain, shortness of breath, weakness on one side, black or bloody stools, vomiting blood, a skin rash or blisters, or swelling of the face or throat. These can be signs of heart, stomach or allergic problems.

Can I take it with aspirin or other medicines?

▾
Taking it with aspirin is generally not recommended because of a higher risk of side effects. Tell me if you take warfarin, water pills, blood pressure medicines like ACE inhibitors, lithium, or methotrexate, since these can interact.

Is it safe in pregnancy?

▾
Avoid nabumetone from about 30 weeks of pregnancy onward, because it can harm the baby's heart circulation. Between about 20 and 30 weeks it should be limited to the lowest dose for the shortest time. Talk with your doctor if you're pregnant or planning to be.

Is Nabumetone available over the counter?

▾
No. Nabumetone is a prescription medicine: every Nabumetone product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Nabumetone first available?

▾
The earliest FDA record we hold for Nabumetone is from 1991: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Nabumetone was first used.

Who makes Nabumetone?

▾
26 companies currently list Nabumetone products in the FDA's NDC Directory, including Bryant Ranch Prepack, Proficient Rx LP, Lgm Pharma Solutions, Llc. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Nabumetone on HelloPharmacist

Detailed data & references for Nabumetone Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Nabumetone forms and strengths (how it comes)

Nabumetone is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Nabumetone inactive ingredients by manufacturer.

Tablet

By mouth
Brands Relafen Ds
How this form is used
What it may be used for
  • Relafen DS is used for relief of signs and symptoms of osteoarthritis and rheumatoid arthritis.
  • Nabumetone tablets are used for relief of signs and symptoms of osteoarthritis and rheumatoid arthritis.
Important instructions
  • Relafen DS is taken by mouth, once daily or in two daily doses, with or without food.
  • Nabumetone tablets are taken by mouth, once daily or in two daily doses, with or without food.
  • Nabumetone tablets: the dose is adjusted to your response, using the lowest effective dose.
Available strengths 3 strengths
138 FDA-listed product records ⓘ

Nabumetone on the U.S. market: products, makers and brands

How Nabumetone appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

26 companies list 64 Nabumetone product records with the FDA, mostly as tablet; the earliest marketing or approval year on record is 1991. Brand names on the directory include Relafen, Relafen Ds; the rest are generics.

1
Dose forms ⓘ
26
Labelers (makers, repackagers, distributors)
5
Brand names
64
FDA-listed product records ⓘ
1991
Earliest FDA record ⓘ

Also listed with the FDA, not a patient dose form: Powder (5) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Bryant Ranch Prepack19%
Proficient Rx LP8%
Lgm Pharma Solutions, Llc5%
Northwind Health Company, LLC5%
PD-Rx Pharmaceuticals, Inc.5%
A-S Medication Solutions3%
Other makers56%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Nabumetone is used (Medicaid data)

A general measure of how commonly Nabumetone is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Nabumetone is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

262,800
Medicaid prescriptions filled (Q1–Q4 2025)
$70.2M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Nabumetone prescribed? Of the 1,601 medications we measure, Nabumetone ranks #346 by Medicaid prescriptions — more than 78% of them.

Where Nabumetone ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5

Utilization by Nabumetone product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 750 mg oral tablet is the most-dispensed Nabumetone product — about 54% of these Medicaid prescriptions.

nabumetone 750 MG Oral Tablet Most dispensed

141,731 Medicaid prescriptions (Q1–Q4 2025) 54% of Nabumetone prescriptions shown $1.9M gross reimbursement (before rebates) ≈ $14 per prescription (gross)

Summed across the 10 of 168 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 311893

nabumetone 500 MG Oral Tablet

103,021 Medicaid prescriptions (Q1–Q4 2025) 39% of Nabumetone prescriptions shown $1.4M gross reimbursement (before rebates) ≈ $13 per prescription (gross)

Summed across the 10 of 177 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 311892

nabumetone 1000 MG Oral Tablet

18,048 Medicaid prescriptions (Q1–Q4 2025) 7% of Nabumetone prescriptions shown $67M gross reimbursement (before rebates) ≈ $3,710 per prescription (gross)

Summed across the 2 of 7 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 427726

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Nabumetone, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 22 of 352 listed Nabumetone NDCs with Medicaid activity.

Compare Nabumetone products

A representative set of FDA-listed product records for Nabumetone — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 64 of 64 products — FDA National Drug Code Directory. See every product, package size and price: browse all 64 Nabumetone NDCs →

Nabumetone recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list no Nabumetone recalls since July 2021.

✅No Nabumetone recalls on record since July 2021

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Nabumetone RxCUI 31448 3 dose forms · 5 strengths
  1. Dose form (SCDF) Oral Solution RxCUI 393528 No current FDA listing
    Clinical drug / strength (SCD) 2.5 MG/ML RxCUI 392641
  2. Dose form (SCDF) Oral Suspension RxCUI 372976 No current FDA listing
    Clinical drug / strength (SCD) 100 MG/ML RxCUI 105953
  3. Dose form (SCDF) Oral Tablet RxCUI 378684 In current FDA listings
    Clinical drug / strength (SCD) 500 MG RxCUI 311892 750 MG RxCUI 311893 1000 MG RxCUI 427726

Look up RxCUI 31448 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

💵 What Nabumetone costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Tablet · Oral 1000 mg $31.67 per tablet NDC details & price history
Tablet, Film Coated · Oral 500 mg $0.128 per tablet NDC details & price history
Tablet, Film Coated · Oral 750 mg $0.183 per tablet NDC details & price history
Tablet, Film Coated 500 mg $0.128 per tablet NDC details & price history
Tablet, Film Coated 750 mg $0.183 per tablet NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Nabumetone brand names

Nabumetone is sold under 2 brand names in the FDA directory — Relafen, Relafen Ds. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Relafen Relafen Ds

Who makes Nabumetone: manufacturers and labelers

26 companies list Nabumetone products with the FDA. By number of product records, the largest are Bryant Ranch Prepack, Proficient Rx LP, Lgm Pharma Solutions, Llc. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Bryant Ranch Prepack 12 Proficient Rx LP 5 Lgm Pharma Solutions, Llc 3 Northwind Health Company, LLC 3 PD-Rx Pharmaceuticals, Inc. 3 A-S Medication Solutions 2 ANI Pharmaceuticals, Inc. 2 Asclemed Usa Inc. 2 Actavis Pharma, Inc. 2 Advanced Rx of Tennessee, LLC 2 Chartwell RX, LLC 2 Cipla USA Inc. 2 Exelan Pharmaceuticals Inc. 2 Lupin Pharmaceuticals, Inc. 2 Preferred Pharmaceuticals Inc. 2 Quality Care Products, LLC 2 Remedyrepack Inc. 2 ScieGen Pharmaceuticals Inc 2 Sportpharm LLC 2 St. Mary's Medical Park Pharmacy 2 Westminster Pharmaceuticals, LLC 2 direct rx 2 Advanced Rx Pharmacy of Tennessee, LLC 1 American Health Packaging 1

…and 2 more on the FDA NDC directory.

Nabumetone drug class (RxNorm)

Nabumetone belongs to the Nonsteroidal Anti-inflammatory Drug class.

Pharmacologic class Nonsteroidal Anti-inflammatory Drug
Drug family (ATC) Other antiinflammatory and antirheumatic agents, non-steroids
How it works Cyclooxygenase Inhibitors

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Nabumetone page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Aug 6, 2025
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Nabumetone.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Nabumetone after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
55
Finished products in the current FDA directory
64
Companies listing them (makers, repackagers, distributors)
26
FDA labeler codes behind them ⓘ
30
Linked representative label ⓘ
LGM Pharma Solutions, LLC
Linked label effective
Aug 6, 2025
Composite sections available
20
Linked SPL Set ID
ef7c3da8-797f-4ea9-8999-53509785a0f7
Linked SPL Document ID
cf52d275-4853-4576-832a-07630bb644dc
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. LGM Pharma Solutions, LLC is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →