FDA-filed SPL labeling · retrieved through openFDA

Morphine

Morphine is a powerful prescription opioid pain reliever used for moderate-to-severe pain when other treatments aren't enough.

Brand names Arymo ERKadianMorphabondMS ContinAvinza +9 more
Drug class ⓘ Opioid Agonist
Rx Schedule CII Forms 6 Routes Oral · Intravenous · Intramuscular; Intravenous · Rectal +5
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 69 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveMay 7, 2026
Clinical labels in scope ⓘ69
AvailabilityRx
Earliest approval/marketing year ⓘ1977
FDA-listed product records ⓘ512
Boxed warningYes
How we combine label and product data →
Other forms & routes:
Injection Rectal
⭐ Morphine at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Morphine is one of the strongest pain medicines available and is reserved for severe pain that nothing else can control. It works well, but carries serious risks — especially slowed breathing, addiction, and dangerous interactions with alcohol and sedatives. Take it exactly as prescribed, never share it, keep naloxone on hand, and stay in close contact with your healthcare team.
How we write & review this content — our editorial policy →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

Morphine carries serious, life-threatening risks that you must know about before taking it.

Breathing can slow or stop entirely — this risk is greatest when you start the medication or after a dose increase. Swallow extended-release capsules whole; crushing or chewing can release a fatal dose all at once.

Never drink alcohol or use any product containing alcohol while taking morphine — this combination can cause fatal morphine levels in your blood.

Combining morphine with benzodiazepines (like Xanax or Valium), sleep aids, or other sedatives can lead to deep sedation, coma, stopped breathing, and death.

Keep morphine away from children — even one accidental dose can be deadly to a child.

If you are pregnant, using morphine for an extended time can cause your newborn to go through withdrawal (neonatal opioid withdrawal syndrome), which is serious and requires medical treatment. Morphine also carries a real risk of addiction, abuse, and misuse, which can lead to overdose and death — even in people who take it exactly as prescribed.

Read the full warning on DailyMed →

📖 Morphine: Patient Information Guide

A plain-language walkthrough of Morphine — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for▾

Morphine is prescribed for severe pain — acute or chronic — when other treatments haven't provided enough relief. Main uses include:

  • Severe acute pain (such as post-surgical pain or injury-related pain)
  • Severe chronic pain in adults when non-opioid options have failed or are not tolerated
  • Severe chronic pain in opioid-tolerant adults (higher-concentration form only)

It is only appropriate when the expected benefit clearly outweighs the substantial risks, and it should be used at the lowest effective dose for the shortest time needed.

⚙️How it works▾

Morphine binds to mu-opioid receptors — specific docking sites found throughout the brain and spinal cord — and activates them fully. This activation blocks pain signals and changes the way the brain interprets pain. Because morphine is a full opioid agonist, its pain-relieving effect keeps increasing with the dose (no ceiling), though side effects like breathing suppression set the practical limit.

Beyond pain relief, morphine also acts on the brainstem's breathing center (which is why it can slow breathing), on the gut (causing constipation and slowed digestion), and on blood vessels (causing blood pressure to drop, especially when standing). It can also affect hormone systems with long-term use.

💊How it's taken▾

Morphine oral solution is generally taken every 4 hours as needed; extended-release capsules are taken once daily. Both can be taken with or without food, though a high-fat meal may slightly delay how quickly the extended-release form starts working.

  • Swallow extended-release capsules whole — never crush, break, or chew them
  • Extended-release capsule pellets may be sprinkled on applesauce if swallowing is difficult, but never crushed
  • Steady, stable blood levels are typically reached after 2–3 days of regular once-daily dosing
  • Dose is always set individually by your prescriber — follow their instructions exactly
🤒Side effects — in detail▾

The most common side effects of morphine include:

  • Constipation (very common — talk to your doctor about prevention)
  • Nausea and vomiting
  • Drowsiness or sleepiness
  • Dizziness
  • Anxiety or confusion
  • Dry mouth
  • Sweating
  • Rash or itching

Serious reactions to watch for include severely slowed or stopped breathing, extreme drowsiness or unresponsiveness, fainting from low blood pressure, and signs of adrenal insufficiency (persistent nausea, weakness, dizziness). Get emergency help immediately if any of these occur.

⚠️Warnings & precautions▾
  • Respiratory depression (dangerously slow breathing): The most serious risk. Most likely at the start of therapy or after dose increases — and greatly worsened by alcohol, sedatives, or benzodiazepines.
  • Addiction, abuse, and misuse: Can occur even at prescribed doses. Risk is higher with a personal or family history of substance use disorder. Morphine is a Schedule II controlled substance.
  • Alcohol is absolutely prohibited: Drinking alcohol — or using products containing alcohol — while taking morphine can cause a fatal overdose.
  • Keep away from children: Accidental ingestion by a child can be fatal.
  • Opioid-induced hyperalgesia: In rare cases, morphine can paradoxically make pain worse with continued use.
  • Hormonal effects: Long-term use can disrupt hormone levels, potentially causing low libido, erectile dysfunction, irregular periods, or infertility.
  • Increased intracranial pressure: Use with caution (and avoid if possible) in people with head injuries, brain tumors, or reduced consciousness.
🔀What it interacts with▾

Morphine has several critical drug and substance interactions that can be life-threatening:

  • Alcohol — raises morphine blood levels to potentially fatal levels; avoid completely
  • Benzodiazepines and sedatives (e.g., diazepam, alprazolam, sleep aids) — combined use can cause respiratory depression, coma, and death
  • Other opioids — additive breathing and sedation risks
  • MAOIs (certain antidepressants like phenelzine or selegiline) — strictly contraindicated; must wait at least 14 days after stopping an MAOI
  • Serotonergic drugs (SSRIs, SNRIs, tricyclics, triptans, tramadol) — risk of serotonin syndrome, a potentially dangerous reaction involving agitation, rapid heart rate, and high body temperature
  • Gabapentin or pregabalin — increases sedation and breathing depression risk
  • Muscle relaxants, antipsychotics, anesthetics — increased CNS depression

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it▾
  • Do NOT take morphine if you have significant respiratory (breathing) depression, severe unmonitored asthma, a bowel obstruction, or a known allergy to morphine
  • Do NOT take morphine if you have used an MAOI antidepressant within the past 14 days
  • Tell your doctor if you have a history of addiction, substance use disorder, or mental illness
  • Tell your doctor about any lung disease, breathing problems, or sleep apnea
  • Tell your doctor if you have head injuries, brain tumors, or raised pressure in your skull
  • Tell your doctor about any liver or kidney problems
  • Tell your doctor if you have low blood pressure or circulatory problems
  • Pregnancy: morphine can harm the fetus and cause newborn withdrawal syndrome — discuss risks openly with your doctor
  • Older adults and frail or malnourished individuals face a higher risk of breathing problems and need close monitoring
🚑If you take too much▾

Signs of a morphine overdose include very slow or stopped breathing, extreme sleepiness leading to stupor or coma, limpness, cold clammy skin, pinpoint pupils, and abnormal snoring or gurgling sounds. Call 911 immediately — this is a medical emergency. Naloxone (an opioid reversal medicine) can rapidly reverse an overdose, but because extended-release morphine continues releasing for 36–48 hours after ingestion, repeat doses of naloxone and prolonged monitoring may be needed.

📡Pharmacodynamics — effects in the body▾

Morphine directly slows the brain's breathing center, making it less responsive to rising carbon dioxide — this is why breathing can become dangerously slow at high doses. It also causes the pupils to become very small (pinpoint pupils), slows movement through the gut leading to constipation, and relaxes blood vessel walls causing blood pressure to drop (especially when standing up). With long-term use, morphine affects hormone-producing glands, suppressing stress hormones and sex hormones while increasing prolactin and growth hormone levels.

🔬Pharmacokinetics — how your body processes it▾

When taken by mouth, only about 40% or less of morphine actually reaches the bloodstream due to extensive first-pass metabolism in the gut and liver — and this varies considerably from person to person. The extended-release capsule form begins releasing morphine within 30 minutes and maintains levels over a 24-hour period; steady blood levels are reached after about 2–3 days of once-daily dosing. Food does not significantly change the total amount of morphine absorbed, though a high-fat meal may delay the initial rise in levels by about an hour.

📦How to store it▾

Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) . Protect from light and moisture. Dispense in a sealed, tamper-evident, child-resistant, light-resistant container.

📄 Written from Morphine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

172

Supplements & herbs that interact with Morphine

172 supplements and herbal products have documented interactions with Morphine in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 8
  • Moderate · 138
  • Minor · 26
1,4-BUTANEDIOL Major ACTIVATED CHARCOAL Major BEER Major GAMMA-HYDROXYBUTYRATE (GHB) Major KAVA Major L-TRYPTOPHAN Major ST. JOHN'S WORT Major WINE Major +164 more
Every supplement checked against Morphine — ranked by severity The full interaction hub: 8 major · 138 moderate · 26 minor · every one linked to its full report. Check Morphine against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Morphine — the kind of thing our pharmacy team would talk through with you at the counter.

Why is my doctor prescribing morphine instead of something milder? ▾
Morphine is typically prescribed only when your pain is severe enough that other options — like non-opioid medicines or weaker opioid combinations — haven't worked or aren't expected to work. Your doctor has weighed those risks carefully and determined that the benefit for your pain level outweighs the risks. If you have questions about why another option wasn't chosen, that's a completely fair conversation to have with your prescriber.
Can I drink alcohol while taking morphine? ▾
No — and this is one of the most important rules with morphine. Alcohol combined with morphine can push your morphine blood levels to life-threatening highs. This means no wine, beer, spirits, or any products — like some cough syrups or mouthwashes — that contain alcohol. This applies every day you're taking morphine.
What side effects should I just manage at home versus call the doctor about? ▾
Constipation, nausea, and some drowsiness are common — especially in the first few days — and can often be managed with your doctor's guidance (for example, a stool softener for constipation). But call for emergency help right away if your breathing becomes very slow or shallow, if you're extremely hard to wake up, or if you feel faint and limp. Those are overdose warning signs and need 911, not a phone call to the office.
What is naloxone, and do I need it? ▾
Naloxone is a medicine that can rapidly reverse a morphine overdose. Your doctor should discuss it with you when prescribing morphine — especially if you're at higher risk of overdose or if people around you could accidentally be exposed. It's worth having on hand, and your pharmacist can explain how to use it and where to get it.
I'm pregnant — is it safe to keep taking morphine? ▾
This is an important conversation to have with your doctor right away. Using morphine for an extended period during pregnancy can cause your newborn to go through opioid withdrawal after birth — a serious condition that requires medical care. That doesn't automatically mean you must stop, but your doctor needs to know so they can monitor you closely and make sure support is in place for your baby if needed.
Can I crush or split the extended-release capsule to make it easier to swallow? ▾
No — never crush, chew, or break the extended-release capsules. The whole point of the extended-release design is to deliver morphine slowly and steadily over 24 hours. Crushing it releases the entire dose at once, which can be fatal. If swallowing is a problem, talk to your doctor or pharmacist — the capsule pellets can be carefully sprinkled onto a small amount of applesauce and swallowed, but never chewed.
Is Morphine available over the counter? ▾
Morphine is dispensed by prescription according to its FDA labeling, so it isn't sold over the counter. Your prescriber and pharmacist will determine if it's appropriate for you.
Is Morphine a controlled substance? ▾
Yes — Morphine is a federally controlled substance (Schedule II) in the United States, so how it is prescribed, refilled and dispensed is regulated by the DEA.
When was Morphine first available? ▾
Morphine has been available in the United States since at least 1977, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Morphine? ▾
Morphine is supplied by 60 manufacturers listed in the FDA NDC Directory, including Bryant Ranch Prepack, Hikma Pharmaceuticals USA Inc., SpecGx LLC.

💬 Answers drafted from Morphine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

📊Morphine supplement interactions172 checked — ranked by severity 🌿Drug & Supplement CheckerMorphine vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Morphine NDCs & costs 🅰️Browse Drugs A–ZLook up any medication

💊 How Morphine comes

Morphine is available in 6 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Extended-release tablet

By mouth
Brands MS Contin
Available strengths 5 strengths
15 mg 30 mg 60 mg 100 mg 200 mg
153 FDA-listed product records ⓘ

Rectal suppository

Rectal
Available strengths 4 strengths
5 mg 10 mg 20 mg 30 mg
16 FDA-listed product records ⓘ

📊 Morphine across the U.S. market

How Morphine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

6
Dose forms ⓘ
60
Manufacturers
11
Brand names
512
FDA-listed product records ⓘ
1977
First marketed ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (11) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Bryant Ranch Prepack15%
Hikma Pharmaceuticals USA Inc.10%
SpecGx LLC7%
Upsher-Smith Laboratories, LLC5%
Actavis Pharma, Inc.5%
Hospira, Inc.5%
Other makers53%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Morphine is used

A general measure of how commonly Morphine is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Morphine is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

562,550
Medicaid prescriptions filled (Q1–Q4 2025)
$18.4M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Morphine prescribed? Of the 1,596 medications we measure, Morphine ranks #252 by Medicaid prescriptions — more than 84% of them.

Where Morphine ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #252 of 1,596
#247 Benzoyl Peroxide 583,362 Rx #248 Iohexol 580,886 Rx #249 Estradiol Transdermal... 575,018 Rx #250 Olopatadine Ophthalmic 567,428 Rx #251 Isosorbide 563,613 Rx #252 Morphine 562,550 Rx #253 Chlorthalidone 561,590 Rx #254 Bisacodyl 542,387 Rx #255 Metronidazole Vaginal 541,965 Rx #256 Methotrexate 533,549 Rx #257 Labetalol 525,457 Rx

Utilization by Morphine product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 15 mg extended release oral tablet is the most-dispensed Morphine product — about 20% of these Medicaid prescriptions.

morphine sulfate 15 MG Extended Release Oral Tablet Most dispensed

114,853 Medicaid prescriptions (Q1–Q4 2025) 20% of Morphine prescriptions shown $2.3M gross reimbursement (before rebates) ≈ $20 per prescription (gross)

Summed across the 9 of 57 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 891881

morphine sulfate 30 MG Extended Release Oral Tablet

81,813 Medicaid prescriptions (Q1–Q4 2025) 15% of Morphine prescriptions shown $2.2M gross reimbursement (before rebates) ≈ $27 per prescription (gross)

Summed across the 8 of 51 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 891888

1 ML morphine sulfate 4 MG/ML Injection

78,802 Medicaid prescriptions (Q1–Q4 2025) 14% of Morphine prescriptions shown $2.1M gross reimbursement (before rebates) ≈ $27 per prescription (gross)

Summed across the 3 of 6 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1732006

1 ML morphine sulfate 4 MG/ML Cartridge

73,039 Medicaid prescriptions (Q1–Q4 2025) 13% of Morphine prescriptions shown $2.1M gross reimbursement (before rebates) ≈ $29 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1732014

morphine sulfate 15 MG Oral Tablet

59,580 Medicaid prescriptions (Q1–Q4 2025) 11% of Morphine prescriptions shown $1.2M gross reimbursement (before rebates) ≈ $20 per prescription (gross)

Summed across the 5 of 27 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 892582

1 ML morphine sulfate 2 MG/ML Cartridge

39,916 Medicaid prescriptions (Q1–Q4 2025) 7% of Morphine prescriptions shown $2.1M gross reimbursement (before rebates) ≈ $53 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1729197

1 ML morphine sulfate 4 MG/ML Prefilled Syringe

29,939 Medicaid prescriptions (Q1–Q4 2025) 5% of Morphine prescriptions shown $2.4M gross reimbursement (before rebates) ≈ $82 per prescription (gross)

Summed across the 3 of 7 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 998213

1 ML morphine sulfate 2 MG/ML Prefilled Syringe

17,995 Medicaid prescriptions (Q1–Q4 2025) 3% of Morphine prescriptions shown $1M gross reimbursement (before rebates) ≈ $58 per prescription (gross)

Summed across the 3 of 7 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 998212

morphine sulfate 60 MG Extended Release Oral Tablet

16,971 Medicaid prescriptions (Q1–Q4 2025) 3% of Morphine prescriptions shown $704,072 gross reimbursement (before rebates) ≈ $41 per prescription (gross)

Summed across the 4 of 46 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 891893

morphine sulfate 30 MG Oral Tablet

16,478 Medicaid prescriptions (Q1–Q4 2025) 3% of Morphine prescriptions shown $582,351 gross reimbursement (before rebates) ≈ $35 per prescription (gross)

Summed across the 5 of 29 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 892672

1 ML morphine sulfate 10 MG/ML Injection

8,076 Medicaid prescriptions (Q1–Q4 2025) 1% of Morphine prescriptions shown $411,321 gross reimbursement (before rebates) ≈ $51 per prescription (gross)

Summed across the 2 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1731993

morphine sulfate 20 MG/ML Oral Solution

7,657 Medicaid prescriptions (Q1–Q4 2025) 1% of Morphine prescriptions shown $153,811 gross reimbursement (before rebates) ≈ $20 per prescription (gross)

Summed across the 9 of 45 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 892625

1 ML morphine sulfate 2 MG/ML Injection

6,869 Medicaid prescriptions (Q1–Q4 2025) 1% of Morphine prescriptions shown $273,697 gross reimbursement (before rebates) ≈ $40 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2003714

morphine sulfate 2 MG/ML Oral Solution

3,282 Medicaid prescriptions (Q1–Q4 2025) <1% of Morphine prescriptions shown $52,793 gross reimbursement (before rebates) ≈ $16 per prescription (gross)

Summed across the 3 of 26 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 892589

morphine sulfate 100 MG Extended Release Oral Tablet

3,113 Medicaid prescriptions (Q1–Q4 2025) <1% of Morphine prescriptions shown $190,801 gross reimbursement (before rebates) ≈ $61 per prescription (gross)

Summed across the 3 of 32 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 891874

1 ML morphine sulfate 10 MG/ML Cartridge

1,283 Medicaid prescriptions (Q1–Q4 2025) <1% of Morphine prescriptions shown $85,953 gross reimbursement (before rebates) ≈ $67 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1731995

10 ML morphine sulfate 1 MG/ML Injection

825 Medicaid prescriptions (Q1–Q4 2025) <1% of Morphine prescriptions shown $86,769 gross reimbursement (before rebates) ≈ $105 per prescription (gross)

Summed across the 2 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1728800

10 ML morphine sulfate 0.5 MG/ML Injection

447 Medicaid prescriptions (Q1–Q4 2025) <1% of Morphine prescriptions shown $19,313 gross reimbursement (before rebates) ≈ $43 per prescription (gross)

Summed across the 2 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1728783

morphine sulfate 4 MG/ML Oral Solution

363 Medicaid prescriptions (Q1–Q4 2025) <1% of Morphine prescriptions shown $6,933 gross reimbursement (before rebates) ≈ $19 per prescription (gross)

Summed across the 2 of 13 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 894780

1 ML morphine sulfate 8 MG/ML Injection

272 Medicaid prescriptions (Q1–Q4 2025) <1% of Morphine prescriptions shown $1,877 gross reimbursement (before rebates) ≈ $6.90 per prescription (gross)

Summed across the 1 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1732011

morphine sulfate 200 MG Extended Release Oral Tablet

214 Medicaid prescriptions (Q1–Q4 2025) <1% of Morphine prescriptions shown $30,358 gross reimbursement (before rebates) ≈ $142 per prescription (gross)

Summed across the 2 of 17 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 892646

20 ML morphine sulfate 25 MG/ML Injection

102 Medicaid prescriptions (Q1–Q4 2025) <1% of Morphine prescriptions shown $64,425 gross reimbursement (before rebates) ≈ $632 per prescription (gross)

Summed across the 2 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1731522

1 ML morphine sulfate 10 MG/ML Prefilled Syringe

66 Medicaid prescriptions (Q1–Q4 2025) <1% of Morphine prescriptions shown $272 gross reimbursement (before rebates) ≈ $4.12 per prescription (gross)

Summed across the 1 of 5 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 894912

morphine sulfate 20 MG Extended Release Oral Capsule

50 Medicaid prescriptions (Q1–Q4 2025) <1% of Morphine prescriptions shown $6,686 gross reimbursement (before rebates) ≈ $134 per prescription (gross)

Summed across the 1 of 8 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 892596

20 ML morphine sulfate 10 MG/ML Injection

46 Medicaid prescriptions (Q1–Q4 2025) <1% of Morphine prescriptions shown $7,417 gross reimbursement (before rebates) ≈ $161 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1731998

morphine sulfate 10 MG Extended Release Oral Capsule

26 Medicaid prescriptions (Q1–Q4 2025) <1% of Morphine prescriptions shown $3,366 gross reimbursement (before rebates) ≈ $129 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 892494

24 HR morphine sulfate 30 MG Extended Release Oral Capsule

12 Medicaid prescriptions (Q1–Q4 2025) <1% of Morphine prescriptions shown $705 gross reimbursement (before rebates) ≈ $59 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 892342

Other Morphine products — combination packs and listings not yet matched to a specific clinical product (kept visible so every prescription is accounted for)

461 Medicaid prescriptions (Q1–Q4 2025) <1% of Morphine prescriptions shown $200,388 gross reimbursement (before rebates) ≈ $435 per prescription (gross)

Summed across the 2 of 128 listed NDC products with Medicaid activity.

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Morphine, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 79 of 535 listed Morphine NDCs with Medicaid activity.

🔍 Compare Morphine products

A representative set of FDA-listed product records for Morphine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 200 of 512 products — FDA National Drug Code Directory. See every product, package size and price: browse all 512 Morphine NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Morphine RxCUI 7052 12 dose forms · 79 strengths
  1. Dose form (SCDF) Auto-Injector RxCUI 1731577 In current FDA listings
    Clinical drug / strength (SCD) 0.7 ML morphine sulfate 14.3 MG/ML RxCUI 894911
  3. Dose form (SCDF) Extended Release Oral Capsule RxCUI 374654 In current FDA listings
    Clinical drug / strength (SCD) sulfate 10 MG RxCUI 892494 sulfate 100 MG RxCUI 892554 sulfate 20 MG RxCUI 892596 sulfate 30 MG RxCUI 892345 sulfate 40 MG RxCUI 1303736 sulfate 50 MG RxCUI 894801 sulfate 60 MG RxCUI 892352 sulfate 80 MG RxCUI 894814 24 HR morphine sulfate 120 MG RxCUI 892297 24 HR morphine sulfate 30 MG RxCUI 892342 24 HR morphine sulfate 45 MG RxCUI 894942 24 HR morphine sulfate 60 MG RxCUI 892349 24 HR morphine sulfate 75 MG RxCUI 894970 24 HR morphine sulfate 90 MG RxCUI 892355
  5. Dose form (SCDF) Injectable Solution RxCUI 372956 In current FDA listings
    Clinical drug / strength (SCD) sulfate 10 MG/ML RxCUI 892531 sulfate 15 MG/ML RxCUI 895194 sulfate 20 MG/ML RxCUI 895202 sulfate 30 MG/ML RxCUI 895213 sulfate liposomal 10 MG/ML RxCUI 895975
  6. Dose form (SCDF) Injection RxCUI 1728776 In current FDA listings
    Clinical drug / strength (SCD) 1 ML morphine sulfate 10 MG/ML RxCUI 1731993 1 ML morphine sulfate 2 MG/ML RxCUI 2003714 1 ML morphine sulfate 4 MG/ML RxCUI 1732006 1 ML morphine sulfate 5 MG/ML RxCUI 1732136 1 ML morphine sulfate 8 MG/ML RxCUI 1732011 1.5 ML morphine sulfate liposomal 10 MG/ML RxCUI 1731990 2 ML morphine sulfate 0.5 MG/ML RxCUI 1728791 2 ML morphine sulfate 1 MG/ML RxCUI 1728805 4 ML morphine sulfate 25 MG/ML RxCUI 1731520 10 ML morphine sulfate 0.5 MG/ML RxCUI 1728783 10 ML morphine sulfate 1 MG/ML RxCUI 1728800 20 ML morphine sulfate 10 MG/ML RxCUI 1731998 20 ML morphine sulfate 25 MG/ML RxCUI 1731522 20 ML morphine sulfate 50 MG/ML RxCUI 1731537 30 ML morphine sulfate 1 MG/ML RxCUI 1728999 30 ML morphine sulfate 5 MG/ML RxCUI 1732138 50 ML morphine sulfate 50 MG/ML RxCUI 1731545
  7. Dose form (SCDF) Oral Capsule RxCUI 372961 No current FDA listing
    Clinical drug / strength (SCD) sulfate 15 MG RxCUI 892579 sulfate 30 MG RxCUI 892669
  8. Dose form (SCDF) Oral Solution RxCUI 106841 In current FDA listings
    Clinical drug / strength (SCD) sulfate 10 MG/ML RxCUI 895016 sulfate 2 MG/ML RxCUI 892589 sulfate 20 MG/ML RxCUI 892625 sulfate 4 MG/ML RxCUI 894780 sulfate 6 MG/ML RxCUI 895238
  9. Dose form (SCDF) Oral Suspension RxCUI 895012 No current FDA listing
    Clinical drug / strength (SCD) sulfate 2 MG/ML RxCUI 895199 sulfate 3 MG/ML RxCUI 895208 sulfate 5 MG/ML RxCUI 895219 sulfate 6.67 MG/ML RxCUI 895240
  10. Dose form (SCDF) Oral Tablet RxCUI 372959 In current FDA listings
    Clinical drug / strength (SCD) sulfate 10 MG RxCUI 895014 sulfate 15 MG RxCUI 892582 sulfate 20 MG RxCUI 895201 sulfate 200 MG RxCUI 895206 sulfate 30 MG RxCUI 892672 sulfate 50 MG RxCUI 895221 sulfate 60 MG RxCUI 895247
  12. Dose form (SCDF) Rectal Suppository RxCUI 372957 In current FDA listings
    Clinical drug / strength (SCD) sulfate 10 MG RxCUI 892516 sulfate 100 MG RxCUI 895022 sulfate 15 MG RxCUI 895185 sulfate 20 MG RxCUI 892603 sulfate 30 MG RxCUI 892678 sulfate 35 MG RxCUI 895215 sulfate 5 MG RxCUI 894807 sulfate 50 MG RxCUI 895227 sulfate 75 MG RxCUI 895248

Look up RxCUI 7052 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Arymo ER Kadian Morphabond MS Contin Avinza Oramorph SR Roxanol-T Infumorph Mitigo Duramorph Opium Tincture Deodorized Infumorph 200 Infumorph 500 Opium

🏭 Manufacturers & labelers

Bryant Ranch Prepack 73 Hikma Pharmaceuticals USA Inc. 49 SpecGx LLC 32 Upsher-Smith Laboratories, LLC 27 Actavis Pharma, Inc. 26 Hospira, Inc. 24 Amneal Pharmaceuticals of New York LLC 21 Precision Dose, Inc. 20 Fresenius Kabi USA, LLC 20 Sun Pharmaceutical Industries, Inc. 15 American Health Packaging 15 Fresenius Kabi, USA LLC 15 Lupin Pharmaceuticals,Inc. 15 Rhodes Pharmaceuticals LLC 14 Rhodes Pharmaceuticals L.P. 13 Nortec Development Associates, Inc. 12 Rhodes Pharmaceuticals L. P. 10 Major Pharmaceuticals 8 Padagis US LLC 8 Mayne Pharma Commercial LLC 6 Piramal Critical Care, Inc. 6 Allergan, Inc. 6 Winder Laboratories LLC 6 Atlantic Biologicals Corp. 6

…and 16 more on the FDA NDC directory.

RxNorm drug class

Morphine belongs to the Opioid Agonist class.

Pharmacologic class Opioid Agonist
Drug family (ATC) Natural opium alkaloids
How it works Full Opioid Agonists

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective May 7, 2026
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Morphine.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Morphine after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
69
NDC products indexed
512
Distinct labelers/manufacturers represented
60
Linked representative label ⓘ
Genus Lifesciences Inc.
Linked label effective
May 7, 2026
Composite sections available
27
Linked SPL Set ID
8a77894b-2137-4f46-8dff-5c7b773d4d16
Linked SPL Document ID
b937d1d0-9ed8-4aa3-9e4a-cce02870e7e9
Open the linked representative label on DailyMed ↗
NDC package records associated with this linked SPL 1

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 69 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Genus Lifesciences Inc. is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.