Estradiol
Estradiol is a form of estrogen used across multiple products and routes to treat menopausal symptoms, low estrogen conditions, and to help prevent postmenopausal osteoporosis.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 37 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾
Estradiol carries serious boxed warnings about cancer, heart and blood vessel problems, and dementia. Women with a uterus who use estrogen without also taking a progestogen (a second hormone) have a significantly higher risk of endometrial cancer (cancer of the uterine lining). Adding a progestogen reduces this risk. Unexplained vaginal bleeding should always be evaluated by a doctor.
Clinical studies have shown that estrogen therapy — alone or combined with progestin — increases the risk of stroke and blood clots (DVT). Estrogen plus progestin also raises the risk of heart attack, pulmonary embolism (blood clots in the lungs), invasive breast cancer, and probable dementia in women 65 and older. Do not use estradiol to prevent heart disease or dementia — it is not approved for these purposes and may cause harm. These risks should be discussed with your prescriber, who will aim for the lowest effective dose for the shortest time possible.
📖 Estradiol: Patient Information Guide
A plain-language walkthrough of Estradiol — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.
🎯What it's used for▾
Estradiol is an estrogen hormone therapy available in many forms, used across several conditions related to low estrogen levels.
- Moderate to severe hot flashes (vasomotor symptoms) due to menopause — supported by most patch, gel, spray, and injection products
- Moderate to severe vaginal and vulvar dryness, irritation, or atrophy due to menopause — supported by Climara, Dotti, Estradiol Transdermal System, EstroGel, Delestrogen, Estradiol Valerate injections, and vaginal insert products
- Moderate to severe dyspareunia (painful intercourse) due to vaginal atrophy — Imvexxy (vaginal insert) is specifically approved for this symptom
- Low estrogen due to hypogonadism (underactive ovaries), castration, or primary ovarian failure — supported by Climara, Dotti, Estradiol Transdermal System, Delestrogen, and Estradiol Valerate injections
- Prevention of postmenopausal osteoporosis — supported by Climara, Dotti, Estradiol Transdermal System, Lyllana, and Menostar patches; Menostar is approved only for this use
- Palliation (symptom relief) of advanced androgen-dependent prostate cancer — Delestrogen and Estradiol Valerate injections only
When estradiol is prescribed solely for vaginal symptoms or solely for osteoporosis prevention, prescribers are advised to consider non-estrogen or topical alternatives first.
⚙️How it works▾
Estradiol is the same estrogen the body makes naturally — and it's the most potent form. It works by attaching to estrogen receptors found in tissues throughout the body, including the reproductive organs, bones, and brain. When estrogen levels fall after menopause, levels of other hormones (LH and FSH) rise sharply, causing hot flashes and other symptoms. Estradiol helps bring these hormone levels back into balance, relieving symptoms and supporting bone density.
Because estradiol bypasses the liver when given through the skin (transdermal route), it enters the bloodstream more directly than oral forms — meaning the body gets more of it per dose compared to swallowing a tablet.
💊How it's taken▾
Estradiol is taken very differently depending on the product. Patches such as Climara and Menostar are applied to the skin once a week; others like Dotti, Lyllana, and Minivelle are applied twice a week. Topical gels (EstroGel, Divigel, Elestrin, Estradiol Gel) are typically applied to the skin daily. Injections are given into the muscle by a healthcare provider at intervals your prescriber sets. Always follow the specific instructions for your product.
- Apply patches to a clean, dry skin area as directed — usually the lower abdomen; avoid the breast
- Never apply a higher dose or use more frequently than prescribed
- Your prescriber will aim for the lowest effective dose and shortest treatment duration
- Treatment should be reviewed regularly to confirm it's still needed
🤒Side effects — in detail▾
Like all hormone therapies, estradiol can cause side effects — some mild and common, others rare but serious.
- Headache
- Breast tenderness
- Irregular vaginal bleeding or spotting
- Nausea
- Back pain
- Depression or mood changes
- Skin redness or irritation at the patch or gel application site
- Upper respiratory infections, sinus congestion, or sinus headache
Serious reactions — including blood clots, stroke, heart attack, severe vision changes, and signs of an allergic reaction — require immediate medical attention. Call 911 or your doctor right away if any of these occur.
⚠️Warnings & precautions▾
- Blood clots and stroke: Estradiol increases the risk of deep vein thrombosis (DVT), pulmonary embolism, and stroke. The risk is higher when combined with a progestin. Stop taking it and seek emergency care if you develop chest pain, leg swelling, or sudden neurological symptoms.
- Endometrial cancer: Women with a uterus who take estrogen without a progestogen face a significantly higher risk of endometrial cancer. A progestogen is typically added to reduce this risk.
- Breast cancer: Estrogen plus progestin therapy is linked to an increased risk of invasive breast cancer. Get regular breast exams and mammograms as recommended by your doctor.
- Ovarian cancer: Hormone therapy has been associated with a modestly increased risk of ovarian cancer.
- Probable dementia: In women 65 and older, both estrogen-alone and estrogen-plus-progestin therapy were linked to an increased risk of probable dementia in WHI studies.
- Gallbladder disease: Estrogen use is associated with a 2- to 4-fold increased risk of gallbladder disease requiring surgery.
- Not for heart disease or dementia prevention: Estradiol should never be used to try to prevent cardiovascular disease or dementia.
🔀What it interacts with▾
Estradiol is broken down by an enzyme in the liver called CYP3A4. Drugs or supplements that affect this enzyme can change how much estradiol is in your blood.
- St. John's Wort, phenobarbital, carbamazepine, rifampin — these speed up breakdown of estradiol, lowering its levels and reducing effectiveness; they may also cause irregular bleeding
- Erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir — these slow the breakdown of estradiol, increasing its levels and raising the risk of side effects
- Grapefruit juice — can increase estradiol blood levels
This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.
📋Before taking it▾
- Do not use estradiol if you have unexplained vaginal bleeding — it must be evaluated first
- Do not use if you have or have had breast cancer or any estrogen-dependent cancer
- Do not use if you have or have had blood clots (DVT or PE), stroke, or heart attack
- Do not use if you have liver disease or liver impairment
- Do not use if you have inherited clotting disorders such as Protein C, Protein S, or antithrombin deficiency
- If you have a uterus, you will likely need to take a progestogen alongside estradiol
- Tell your prescriber if you are pregnant — estradiol is not indicated during pregnancy
- Estradiol passes into breast milk and can reduce milk production; discuss the risks and benefits with your doctor if you are breastfeeding
- Estradiol is generally not for use in children; if bone growth is not complete, periodic bone monitoring is recommended
- Women 65 and older face higher risks of stroke, breast cancer, and probable dementia with estrogen therapy and should discuss these risks carefully with their prescriber
🚑If you take too much▾
Taking too much estradiol may cause nausea, vomiting, breast tenderness, abdominal pain, drowsiness, fatigue, and vaginal bleeding. If you think you've used too much, remove the patch or stop applying the gel, and contact your prescriber or seek medical care right away.
📡Pharmacodynamics — effects in the body▾
Estradiol's blood level does not reliably predict how well it will work for any individual woman or what her risk of side effects will be. This means that comparing estradiol levels between different products or routes is not a reliable way to judge whether one will work better or be safer than another for a given person.
🔬Pharmacokinetics — how your body processes it▾
When estradiol is applied through the skin (transdermal route), it bypasses first-pass metabolism in the liver, making it roughly 20 times more bioavailable than when taken by mouth. Patches deliver estradiol continuously through the skin over their wear period (one week for once-weekly patches), producing steady blood levels with minimal accumulation. Studies show that applying the patch to the buttock rather than the abdomen results in somewhat higher estradiol levels, and that there is considerable variability in how much estradiol different people absorb through their skin.
📦How to store it▾
Store at 20° to 25°C (68° to 77°F). store unpouched.
📄 Written from Estradiol’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →
🩺 Pharmacist Counseling Corner
Quick, plain-English answers to the questions patients ask most about Estradiol — the kind of thing our pharmacy team would talk through with you at the counter.
What exactly is estradiol and why has my doctor prescribed it? ▾
How do I use my estradiol patch correctly? ▾
What side effects are most common and which ones should I call my doctor about right away? ▾
I've heard estrogen increases cancer risk — should I be worried? ▾
Are there any medications or supplements I should avoid while taking estradiol? ▾
How long will I need to take estradiol? ▾
Is Estradiol available over the counter? ▾
When was Estradiol first available? ▾
Who makes Estradiol? ▾
💬 Answers drafted from Estradiol’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →
🧰 Keep exploring
💊 How Estradiol comes
Estradiol is available in 11 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Skin patch
How this form is used
- Climara is used for moderate to severe menopausal hot flashes, vaginal and vulvar atrophy symptoms, low estrogen due to hypogonadism or ovarian failure, and prevention of postmenopausal osteoporosis
- Dotti is used for moderate to severe menopausal hot flashes, vaginal and vulvar atrophy symptoms, low estrogen due to hypogonadism or ovarian failure, and prevention of postmenopausal osteoporosis
- Lyllana is used for moderate to severe menopausal hot flashes and prevention of postmenopausal osteoporosis
- Menostar is used only for prevention of postmenopausal osteoporosis
- Climara is applied to the skin once weekly to a clean, dry area of the lower abdomen; do not apply to the breast
- Dotti and Lyllana are applied to the skin twice weekly
- Menostar is applied once weekly to a clean, dry area of the lower abdomen; do not apply to the breast
- Estradiol Transdermal System is applied to the skin once weekly to the lower abdomen
Show 11 more strengths Show fewer strengths
Tablet
Topical cream, ointment or gel
How this form is used
- EstroGel 0.06% is used for moderate to severe menopausal hot flashes and moderate to severe vaginal and vulvar atrophy symptoms due to menopause
- Divigel is used for moderate to severe menopausal hot flashes
- Estradiol Gel 0.1% is used for moderate to severe menopausal hot flashes
- These gels are applied to the skin; follow your prescriber's instructions for the specific product on application site and frequency
- Use at the lowest effective dose for the shortest time consistent with your treatment goals
- Women with a uterus should also take a progestogen to reduce the risk of endometrial cancer
Show 1 more strength Show fewer strengths
Vaginal cream or gel
Vaginal insert
Show 1 more strength Show fewer strengths
Injection
How this form is used
- Delestrogen is used for moderate to severe menopausal hot flashes, vaginal and vulvar atrophy symptoms, low estrogen due to hypogonadism or ovarian failure, and palliation of advanced androgen-dependent prostate cancer
- Estradiol Valerate injection is used for moderate to severe menopausal hot flashes, vaginal and vulvar atrophy symptoms, low estrogen due to hypogonadism or ovarian failure, and palliation of advanced androgen-dependent prostate cancer
- Delestrogen is given by deep injection into the upper, outer quadrant of the gluteal (buttock) muscle by a healthcare provider
- Estradiol Valerate injection is given by deep intramuscular injection by a healthcare provider
- Women with a uterus receiving injection therapy should also take a progestogen to reduce risk of endometrial cancer
- Dosing intervals should be followed as directed by your prescriber; treatment need should be re-evaluated every 3 to 6 months
Vaginal tablet
Insert or device
How this form is used
- Vaginal estradiol inserts (such as Imvexxy) are used for moderate to severe dyspareunia (painful sex), a symptom of vulvar and vaginal atrophy due to menopause
- Follow your prescriber's specific instructions for insertion technique and frequency
- When used solely for vaginal symptoms, topical vaginal products should be considered first
Oral solution
Spray
Topical (transdermal) gel
📊 Estradiol across the U.S. market
How Estradiol appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
Also listed with the FDA, not a patient dose form: Powder (77) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
📈 How widely Estradiol is used
A general measure of how commonly Estradiol is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Estradiol is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Estradiol prescribed? Of the 1,596 medications we measure, Estradiol ranks #124 by Medicaid prescriptions — more than 92% of them.
Utilization by Estradiol product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
estradiol 0.1 MG/ML Vaginal Cream Most dispensed
Summed across the 6 of 19 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 310169
estradiol 2 MG Oral Tablet
Summed across the 8 of 80 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197659
estradiol 1 MG Oral Tablet
Summed across the 8 of 123 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197658
84 HR estradiol 0.00208 MG/HR Transdermal System
Summed across the 9 of 30 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 242891
estradiol 0.5 MG Oral Tablet
Summed across the 5 of 69 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197657
84 HR estradiol 0.00417 MG/HR Transdermal System
Summed across the 9 of 29 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 242892
estradiol 0.01 MG Vaginal Insert
Summed across the 11 of 27 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 884707
estradiol valerate 20 MG/ML Injectable Solution
Summed across the 4 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 310190
84 HR estradiol 0.00104 MG/HR Transdermal System
Summed across the 8 of 29 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 248478
84 HR estradiol 0.00156 MG/HR Transdermal System
Summed across the 8 of 32 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 241946
168 HR estradiol 0.00208 MG/HR Transdermal System
Summed across the 3 of 13 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 238003
168 HR estradiol 0.00104 MG/HR Transdermal System
Summed across the 3 of 13 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 242333
84 HR estradiol 0.00313 MG/HR Transdermal System
Summed across the 8 of 29 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1149632
168 HR estradiol 0.00417 MG/HR Transdermal System
Summed across the 3 of 13 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 238004
estradiol valerate 40 MG/ML Injectable Solution
Summed across the 4 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 310191
168 HR estradiol 0.00156 MG/HR Transdermal System
Summed across the 3 of 13 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 403922
168 HR estradiol 0.00312 MG/HR Transdermal System
Summed across the 3 of 13 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 241527
estradiol valerate 10 MG/ML Injectable Solution
Summed across the 3 of 3 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 310189
estradiol cypionate 5 MG/ML Injectable Solution
Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 310187
90 DAY estradiol 0.000313 MG/HR Vaginal System
Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 848328
168 HR estradiol 0.0025 MG/HR Transdermal System
Summed across the 3 of 13 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 403923
500 MG estradiol 0.001 MG/MG Topical Gel
Summed across the 6 of 18 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2619679
1000 MG estradiol 0.001 MG/MG Topical Gel
Summed across the 6 of 17 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2619683
estradiol 0.0006 MG/MG Topical Gel
Summed across the 3 of 7 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 226597
250 MG estradiol 0.001 MG/MG Topical Gel
Summed across the 6 of 17 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2619677
estradiol 1.53 MG/ACTUAT Topical Spray
Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 728118
750 MG estradiol 0.001 MG/MG Topical Gel
Summed across the 6 of 16 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2619681
1250 MG estradiol 0.001 MG/MG Topical Gel
Summed across the 5 of 14 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2619685
168 HR estradiol 0.000583 MG/HR Transdermal System
Summed across the 1 of 5 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 476545
90 DAY estradiol 0.00417 MG/HR Vaginal System
Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 848342
90 DAY estradiol 0.00208 MG/HR Vaginal System
Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 848331
Other Estradiol products — combination packs and listings not yet matched to a specific clinical product (kept visible so every prescription is accounted for)
Summed across the 5 of 226 listed NDC products with Medicaid activity.
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Estradiol, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 152 of 883 listed Estradiol NDCs with Medicaid activity.
🔍 Compare Estradiol products
A representative set of FDA-listed product records for Estradiol — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Injection | ||||
| 10 mg/mL | Intramuscular | Hikma Pharmaceuticals USA Inc. × 2 listings | ANDA | View NDC → |
| 20 mg/mL | Intramuscular | Hikma Pharmaceuticals USA Inc. × 2 listings | ANDA | View NDC → |
| 40 mg/mL | Intramuscular | Hikma Pharmaceuticals USA Inc. × 2 listings | ANDA | View NDC → |
| 10 mg/mL | Intramuscular | Par Health USA, LLC | NDA | View NDC → |
| 20 mg/mL | Intramuscular | Par Health USA, LLC | NDA | View NDC → |
| 10 mg/mL | Intramuscular | Par Pharmaceutical, Inc. | NDA | View NDC → |
| 20 mg/mL | Intramuscular | Par Pharmaceutical, Inc. | NDA | View NDC → |
| 40 mg/mL | Intramuscular | Par Pharmaceutical, Inc. | NDA | View NDC → |
| 5 mg/mL | Intramuscular | Pharmacia & Upjohn Company LLC × 2 listings | ANDA | View NDC → |
| 10 mg/mL | Intramuscular | Xiromed, LLC × 3 listings | ANDA | View NDC → |
| 20 mg/mL | Intramuscular | Xiromed, LLC × 3 listings | ANDA | View NDC → |
| 40 mg/mL | Intramuscular | Xiromed, LLC × 3 listings | ANDA | View NDC → |
| 💊Skin patch | ||||
| ESTRADIOL 0.0375 mg/d | Transdermal | A-S Medication Solutions | NDA AUTHORIZED GENERIC | View NDC → |
| 0.025 mg/d | Transdermal | Noven Therapeutics, LLC | NDA AUTHORIZED GENERIC | View NDC → |
| 0.025 mg/d | Transdermal | Noven Therapeutics, LLC | NDA | View NDC → |
| ESTRADIOL 0.025 mg/d | Transdermal | Noven Therapeutics, LLC × 2 listings | NDA | View NDC → |
| ESTRADIOL 0.025 mg/d | Transdermal | Noven Therapeutics, LLC | NDA AUTHORIZED GENERIC | View NDC → |
| 0.0375 mg/d | Transdermal | Noven Therapeutics, LLC | NDA AUTHORIZED GENERIC | View NDC → |
| 0.0375 mg/d | Transdermal | Noven Therapeutics, LLC | NDA | View NDC → |
| ESTRADIOL 0.0375 mg/d | Transdermal | Noven Therapeutics, LLC × 2 listings | NDA | View NDC → |
| ESTRADIOL 0.0375 mg/d | Transdermal | Noven Therapeutics, LLC | NDA AUTHORIZED GENERIC | View NDC → |
| 0.05 mg/d | Transdermal | Noven Therapeutics, LLC | NDA AUTHORIZED GENERIC | View NDC → |
| 0.05 mg/d | Transdermal | Noven Therapeutics, LLC | NDA | View NDC → |
| ESTRADIOL 0.05 mg/d | Transdermal | Noven Therapeutics, LLC × 2 listings | NDA | View NDC → |
| ESTRADIOL 0.05 mg/d | Transdermal | Noven Therapeutics, LLC | NDA AUTHORIZED GENERIC | View NDC → |
| 0.075 mg/d | Transdermal | Noven Therapeutics, LLC | NDA AUTHORIZED GENERIC | View NDC → |
| 0.075 mg/d | Transdermal | Noven Therapeutics, LLC | NDA | View NDC → |
| ESTRADIOL 0.075 mg/d | Transdermal | Noven Therapeutics, LLC | NDA AUTHORIZED GENERIC | View NDC → |
| ESTRADIOL 0.075 mg/d | Transdermal | Noven Therapeutics, LLC × 2 listings | NDA | View NDC → |
| 0.1 mg/d | Transdermal | Noven Therapeutics, LLC | NDA AUTHORIZED GENERIC | View NDC → |
| 0.1 mg/d | Transdermal | Noven Therapeutics, LLC | NDA | View NDC → |
| ESTRADIOL 0.1 mg/d | Transdermal | Noven Therapeutics, LLC | NDA AUTHORIZED GENERIC | View NDC → |
| ESTRADIOL 0.1 mg/d | Transdermal | Noven Therapeutics, LLC × 2 listings | NDA | View NDC → |
| 💊Topical (transdermal) gel | ||||
| 0.75 mg/1.25 g | Transdermal | Encube Ethicals, Inc. | ANDA | View NDC → |
| 💊Topical cream, ointment or gel | ||||
| 0.25 mg/0.25 g | Topical | Amneal Pharmaceuticals NY LLC | ANDA | View NDC → |
| 0.5 mg/0.5 g | Topical | Amneal Pharmaceuticals NY LLC | ANDA | View NDC → |
| 0.75 mg/0.75 g | Topical | Amneal Pharmaceuticals NY LLC | ANDA | View NDC → |
| 1 mg/g | Topical | Amneal Pharmaceuticals NY LLC | ANDA | View NDC → |
| 1.25 mg/1.25 g | Topical | Amneal Pharmaceuticals NY LLC | ANDA | View NDC → |
| 0.25 mg/0.25 g | Topical | ANI Pharmaceuticals, Inc. × 3 listings | ANDA | View NDC → |
| 0.5 mg/0.5 g | Topical | ANI Pharmaceuticals, Inc. × 3 listings | ANDA | View NDC → |
| 0.75 mg/0.75 g | Topical | ANI Pharmaceuticals, Inc. × 3 listings | ANDA | View NDC → |
| 0.75 mg/1.25 g | Topical | ANI Pharmaceuticals, Inc. | ANDA | View NDC → |
| 1 mg/g | Topical | ANI Pharmaceuticals, Inc. × 3 listings | ANDA | View NDC → |
| 1.25 mg/1.25 g | Topical | ANI Pharmaceuticals, Inc. × 3 listings | ANDA | View NDC → |
| 0.75 mg/1.25 g | Topical | ASCEND Therapeutics US, LLC × 3 listings | NDA | View NDC → |
| 0.25 mg/0.25 g | Topical | Bryant Ranch Prepack | ANDA | View NDC → |
| 0.5 mg/0.5 g | Topical | Bryant Ranch Prepack | ANDA | View NDC → |
| 0.75 mg/0.75 g | Topical | Bryant Ranch Prepack | ANDA | View NDC → |
| 1 mg/g | Topical | Bryant Ranch Prepack | ANDA | View NDC → |
| 0.25 mg/0.25 g | Topical | Encube Ethicals, Inc. | ANDA | View NDC → |
| 0.5 mg/0.5 g | Topical | Encube Ethicals, Inc. | ANDA | View NDC → |
| 0.75 mg/0.75 g | Topical | Encube Ethicals, Inc. | ANDA | View NDC → |
| 1 mg/g | Topical | Encube Ethicals, Inc. | ANDA | View NDC → |
| 1.25 mg/1.25 g | Topical | Encube Ethicals, Inc. | ANDA | View NDC → |
| 0.52 mg/0.87 g | Topical | Meda Pharmaceuticals | NDA | View NDC → |
| 0.52 mg/0.87 g | Topical | Meda Pharmaceuticals Inc. | NDA | View NDC → |
| 0.25 mg/0.25 g | Topical | NorthStar Rx LLC × 2 listings | ANDA | View NDC → |
| 0.5 mg/0.5 g | Topical | NorthStar Rx LLC × 2 listings | ANDA | View NDC → |
| 0.75 mg/0.75 g | Topical | NorthStar Rx LLC × 2 listings | ANDA | View NDC → |
| 1 mg/g | Topical | NorthStar Rx LLC × 2 listings | ANDA | View NDC → |
| 1.25 mg/1.25 g | Topical | NorthStar Rx LLC × 2 listings | ANDA | View NDC → |
| 0.25 mg/0.25 g | Topical | Padagis Israel Pharmaceuticals Ltd × 2 listings | ANDA | View NDC → |
| 0.5 mg/0.5 g | Topical | Padagis Israel Pharmaceuticals Ltd × 2 listings | ANDA | View NDC → |
| 0.75 mg/0.75 g | Topical | Padagis Israel Pharmaceuticals Ltd × 2 listings | ANDA | View NDC → |
| 1 mg/g | Topical | Padagis Israel Pharmaceuticals Ltd × 2 listings | ANDA | View NDC → |
| 1.25 mg/1.25 g | Topical | Padagis Israel Pharmaceuticals Ltd × 2 listings | ANDA | View NDC → |
| 0.75 mg/1.25 g | Topical | Solaris Pharma Corporation | ANDA | View NDC → |
| 0.25 mg/0.25 g | Topical | Trigen Laboratories, LLC × 4 listings | NDA | View NDC → |
| 0.5 mg/0.5 g | Topical | Trigen Laboratories, LLC × 4 listings | NDA | View NDC → |
| 0.75 mg/0.75 g | Topical | Trigen Laboratories, LLC × 4 listings | NDA | View NDC → |
| 1 mg/g | Topical | Trigen Laboratories, LLC × 4 listings | NDA | View NDC → |
| 1.25 mg/1.25 g | Topical | Trigen Laboratories, LLC × 4 listings | NDA | View NDC → |
| 0.25 mg/0.25 g | Topical | Vertical Pharmaceuticals, LLC × 3 listings | NDA | View NDC → |
| 0.5 mg/0.5 g | Topical | Vertical Pharmaceuticals, LLC × 3 listings | NDA | View NDC → |
| 0.75 mg/0.75 g | Topical | Vertical Pharmaceuticals, LLC × 3 listings | NDA | View NDC → |
| 1 mg/g | Topical | Vertical Pharmaceuticals, LLC × 3 listings | NDA | View NDC → |
| 1.25 mg/1.25 g | Topical | Vertical Pharmaceuticals, LLC × 3 listings | NDA | View NDC → |
| 0.52 mg/0.87 g | Topical | Viatris Specialty LLC | NDA | View NDC → |
| 0.25 mg/0.25 g | Topical | Xiromed, LLC × 3 listings | ANDA | View NDC → |
| 0.5 mg/0.5 g | Topical | Xiromed, LLC × 3 listings | ANDA | View NDC → |
| 0.75 mg/0.75 g | Topical | Xiromed, LLC × 3 listings | ANDA | View NDC → |
| 1 mg/g | Topical | Xiromed, LLC × 3 listings | ANDA | View NDC → |
| 1.25 mg/1.25 g | Topical | Xiromed, LLC × 3 listings | ANDA | View NDC → |
| 💊Vaginal cream or gel | ||||
| 0.1 mg/g | Vaginal | A-S Medication Solutions × 11 listings | ANDA | View NDC → |
| 0.1 mg/g | Vaginal | Allergan, Inc. × 3 listings | ANDA | View NDC → |
| 0.1 mg/g | Vaginal | Alvogen Inc. × 3 listings | ANDA | View NDC → |
| 0.1 mg/g | Vaginal | Amneal Pharmaceuticals of New York LLC | ANDA | Find on DailyMed ↗ |
| 0.1 mg/g | Vaginal | AvKARE × 3 listings | ANDA | View NDC → |
| 0.1 mg/g | Vaginal | Bryant Ranch Prepack × 8 listings | ANDA | View NDC → |
| 0.1 mg/g | Vaginal | Encube Ethicals, Inc. | ANDA | View NDC → |
| 0.1 mg/g | Vaginal | Mylan Pharmaceuticals Inc. × 3 listings | ANDA | View NDC → |
| 0.1 mg/g | Vaginal | NuCare Pharmaceuticals, Inc. | ANDA | View NDC → |
| 0.1 mg/g | Vaginal | Padagis Israel Pharmaceuticals Ltd × 2 listings | ANDA | View NDC → |
| 0.1 mg/g | Vaginal | Prasco Laboratories × 3 listings | ANDA | View NDC → |
| 0.1 mg/g | Vaginal | Redpharm Drug × 2 listings | ANDA | View NDC → |
| 0.1 mg/g | Vaginal | Teva Pharmaceuticals USA, Inc. × 3 listings | ANDA | View NDC → |
Showing 200 of 724 products — FDA National Drug Code Directory. See every product, package size and price: browse all 724 Estradiol NDCs →
📈 What people report — real-world data (FDA FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Estradiol — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Estradiol in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
🏛️ The road to your pharmacy
How Estradiol went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
🚨 Recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
Source: openFDA drug enforcement (recall) reports.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 4083 11 dose forms · 45 strengths
-
Dose form (SCDF) Drug Implant RxCUI 109022In current FDA listingsClinical drug / strength (SCD) 25 MGRxCUI 25109850 MGRxCUI 199547100 MGRxCUI 199545 -
Dose form (SCDF) Injectable Solution RxCUI 142249In current FDA listingsClinical drug / strength (SCD) cypionate 5 MG/MLRxCUI 310187valerate 10 MG/MLRxCUI 310189valerate 20 MG/MLRxCUI 310190valerate 40 MG/MLRxCUI 310191 -
Dose form (SCDF) Nasal Spray RxCUI 393138No current FDA listingClinical drug / strength (SCD) 0.15 MG/ACTUATRxCUI 389138 -
Dose form (SCDF) Oral Tablet RxCUI 372078In current FDA listingsClinical drug / strength (SCD) valerate 1 MGRxCUI 978948valerate 3 MGRxCUI 9789410.45 MGRxCUI 5770270.5 MGRxCUI 1976570.9 MGRxCUI 4831691 MGRxCUI 1976581.5 MGRxCUI 2053331.8 MGRxCUI 5770292 MGRxCUI 1976594 MGRxCUI 250213 -
Dose form (SCDF) Topical Gel RxCUI 379699In current FDA listingsClinical drug / strength (SCD) 0.0006 MG/MGRxCUI 226597250 MG estradiol 0.001 MG/MGRxCUI 2619677500 MG estradiol 0.001 MG/MGRxCUI 2619679750 MG estradiol 0.001 MG/MGRxCUI 26196811000 MG estradiol 0.001 MG/MGRxCUI 26196831250 MG estradiol 0.001 MG/MGRxCUI 2619685 -
Dose form (SCDF) Topical Lotion RxCUI 402382In current FDA listingsClinical drug / strength (SCD) 2.5 MG/MLRxCUI 688507 -
Dose form (SCDF) Topical Spray RxCUI 728117No current FDA listingClinical drug / strength (SCD) 1.53 MG/ACTUATRxCUI 728118 -
Dose form (SCDF) Transdermal System RxCUI 1805869In current FDA listingsClinical drug / strength (SCD) 84 HR estradiol 0.00104 MG/HRRxCUI 24847884 HR estradiol 0.00156 MG/HRRxCUI 24194684 HR estradiol 0.00208 MG/HRRxCUI 24289184 HR estradiol 0.00313 MG/HRRxCUI 114963284 HR estradiol 0.00417 MG/HRRxCUI 242892168 HR estradiol 0.000583 MG/HRRxCUI 476545168 HR estradiol 0.00104 MG/HRRxCUI 242333168 HR estradiol 0.00156 MG/HRRxCUI 403922168 HR estradiol 0.00208 MG/HRRxCUI 238003168 HR estradiol 0.0025 MG/HRRxCUI 403923168 HR estradiol 0.00312 MG/HRRxCUI 241527168 HR estradiol 0.00417 MG/HRRxCUI 238004 -
Dose form (SCDF) Vaginal Cream RxCUI 378615In current FDA listingsClinical drug / strength (SCD) 0.1 MG/MLRxCUI 310169 -
Dose form (SCDF) Vaginal Insert RxCUI 2109138In current FDA listings -
Dose form (SCDF) Vaginal System RxCUI 2201643In current FDA listingsClinical drug / strength (SCD) 90 DAY estradiol 0.000313 MG/HRRxCUI 84832890 DAY estradiol 0.00208 MG/HRRxCUI 84833190 DAY estradiol 0.00417 MG/HRRxCUI 848342
Look up RxCUI 4083 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
📦 Supply & shortage status
Whether Estradiol is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
🏷️ Sold under these brand names
🏭 Manufacturers & labelers
…and 16 more on the FDA NDC directory.
RxNorm drug class
Estradiol belongs to the Radioactive Diagnostic Agent class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
🔬 Where this comes from
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How we combine label and product data
HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 37 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.
For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Mylan Pharmaceuticals Inc. is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.
This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.