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Estradiol 0.01 MG Vaginal Insert — RxCUI 884707

Name: Estradiol 0.01 MG Vaginal Insert (RxCUI 884707)
Creator: Brian Staiger, PharmD

RxNorm drug concept · Semantic clinical drug

RxCUI 884707 Semantic clinical drug · SCD ● Current RxNorm concept 14 FDA products 25 package NDCs Snapshot Jul 14, 2026

This page is curated, coded, and maintained by Dr. Brian Staiger, PharmD

Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI884707

Official nameEstradiol 0.01 MG Vaginal Insert

Concept typeSemantic clinical drug (SCD)

RxNorm statusCurrent RxNorm concept

Also known asestradiol 10 MCG Vaginal Insert

FDA products mapped14

Package NDCs mapped25

Reported Medicaid activity (SDUD)81,841 prescriptions · 51 state & territory Medicaid programs · latest period Q4 2025

RxNorm release07/06/2026

Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Estradiol Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist

It's designed to ease the moderate to severe hot flashes and night sweats that come with menopause. When estrogen levels drop after menopause, your body's hormonal signals go a bit...
What exactly is this medication supposed to do for me?
Apply it to your upper thigh — alternating right and left sides each day — and spread it over an area roughly the size of two palm prints. Let it dry completely before getting dres...
How do I use the gel correctly so it actually works?

📖 Read our full Estradiol Topical guide →

🕸️ Concept Web — How Estradiol 0.01 MG Vaginal Insert Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.

This page's concept Estradiol 0.01 MG Vaginal Insert RxCUI 884707 Semantic clinical drug · SCD

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

Ingredients 1

The active substance itself — no strength, form, or brand attached yet.
- Estradiol 4083 IN
Brand names 3

The same medicine's trade names. A brand name alone says nothing about strength or form.
- Imvexxy 2048903 BN
- Vagifem 152483 BN
- Yuvafem 1797109 BN
Dose forms 10

The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.
- Estradiol Vaginal Insert 2109138 SCDF
- Estradiol Vaginal Product 1165763 SCDG
- Estradiol Vaginal Insert [Imvexxy] 2109148 SBDF
- Estradiol Vaginal Insert [Vagifem] 2109141 SBDF
- Estradiol Vaginal Insert [Yuvafem] 2109143 SBDF
- Imvexxy Vaginal Product 2048906 SBDG
- Vagifem Vaginal Product 1187123 SBDG
- Yuvafem Vaginal Product 1797112 SBDG
- +2 more in this family
Clinical & branded drugs 7

Ingredient + strength + dose form. These are the concepts real FDA products actually carry.
- Estradiol 0.01 MG 884706 SCDC
- Estradiol 0.01 MG Vaginal Insert [Imvexxy] 2048916 SBD
- Estradiol 0.01 MG Vaginal Insert [Vagifem] 884709 SBD
- Estradiol 0.01 MG Vaginal Insert [Yuvafem] 1797113 SBD
- Estradiol 0.01 MG [Imvexxy] 2048904 SBDC
- Estradiol 0.01 MG [Vagifem] 884708 SBDC
- Estradiol 0.01 MG [Yuvafem] 1797110 SBDC
Packs 4

Fixed collections of drugs packaged and sold together, like dose packs.
- {18 (estradiol 0.01 MG Vaginal Insert [Imvexxy]) } Pack [Imvexxy 10 MCG Starter Pack] 2054318 BPCK
- {8 (estradiol 0.01 MG Vaginal Insert [Imvexxy]) } Pack [Imvexxy 10 MCG Maintenance Pack] 2054316 BPCK
- {18 (estradiol 0.01 MG Vaginal Insert) } Pack 2054317 GPCK
- {8 (estradiol 0.01 MG Vaginal Insert) } Pack 2054315 GPCK

Showing up to 8 concepts per family — 23 of 25 stored related concepts drawn.

These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

{18 (estradiol 0.01 MG Vaginal Insert) } Pack GPCK · 2054317
{8 (estradiol 0.01 MG Vaginal Insert) } Pack GPCK · 2054315
Estradiol 0.01 MG SCDC · 884706
Estradiol Vaginal Insert SCDF · 2109138
Estradiol Vaginal Product SCDG · 1165763

Brand-Name Concepts

Estradiol 0.01 MG Vaginal Insert [Imvexxy] SBD · 2048916
Estradiol 0.01 MG Vaginal Insert [Vagifem] SBD · 884709
Estradiol 0.01 MG Vaginal Insert [Yuvafem] SBD · 1797113
{18 (estradiol 0.01 MG Vaginal Insert [Imvexxy]) } Pack [Imvexxy 10 MCG Starter Pack] BPCK · 2054318
{8 (estradiol 0.01 MG Vaginal Insert [Imvexxy]) } Pack [Imvexxy 10 MCG Maintenance Pack] BPCK · 2054316
Estradiol 0.01 MG [Imvexxy] SBDC · 2048904
Estradiol 0.01 MG [Vagifem] SBDC · 884708
Estradiol 0.01 MG [Yuvafem] SBDC · 1797110
Estradiol Vaginal Insert [Imvexxy] SBDF · 2109148
Estradiol Vaginal Insert [Vagifem] SBDF · 2109141

📦 FDA Products & Package NDCs

14 products · 25 package NDCs

25 package NDCs map to RxCUI 884707 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.

Package NDC	Package	Brand / generic name	Labeler	Marketing start
00093-3223-08	8 BLISTER PACK in 1 CARTON (0093-3223-08) / 1 APPLICATOR in...	Estradiol	Teva Pharmaceuticals USA, Inc.	2017-07-24
00093-3223-97	18 BLISTER PACK in 1 CARTON (0093-3223-97) / 1 APPLICATOR i...	Estradiol	Teva Pharmaceuticals USA, Inc.	2017-07-24
00169-5176-03	8 APPLICATOR in 1 CARTON (0169-5176-03) / 1 INSERT in 1 APP...	Vagifem	Novo Nordisk	2010-01-11
00169-5176-04	18 APPLICATOR in 1 CARTON (0169-5176-04) / 1 INSERT in 1 AP...	Vagifem	Novo Nordisk	2010-01-11
00169-5176-99	6 APPLICATOR in 1 CARTON (0169-5176-99) / 1 INSERT in 1 APP...	Vagifem	Novo Nordisk	2010-01-11
42291-0962-08	8 APPLICATOR in 1 CARTON (42291-962-08) / 1 TABLET in 1 APP...	Yuvafem	AvKARE	2016-10-19
42291-0962-18	18 APPLICATOR in 1 CARTON (42291-962-18) / 1 TABLET in 1 AP...	Yuvafem	AvKARE	2016-10-19
53746-0226-21	8 APPLICATOR in 1 CARTON (53746-226-21) / 1 INSERT in 1 APP...	Estradiol	Amneal Pharmaceuticals of New York LLC	2015-06-07
53746-0226-23	18 APPLICATOR in 1 CARTON (53746-226-23) / 1 INSERT in 1 AP...	Estradiol	Amneal Pharmaceuticals of New York LLC	2015-06-07
59651-0439-08	8 APPLICATOR in 1 CARTON (59651-439-08) / 1 TABLET, FILM CO...	ESTRADIOL VAGINAL INSERTS	Aurobindo Pharma Limited	2024-08-02
59651-0439-18	18 APPLICATOR in 1 CARTON (59651-439-18) / 1 TABLET, FILM C...	ESTRADIOL VAGINAL INSERTS	Aurobindo Pharma Limited	2024-08-02
63629-8803-01	8 BLISTER PACK in 1 CARTON (63629-8803-1) / 1 APPLICATOR in...	Estradiol	Bryant Ranch Prepack	2021-09-10
63629-8804-01	18 BLISTER PACK in 1 CARTON (63629-8804-1) / 1 APPLICATOR i...	Estradiol	Bryant Ranch Prepack	2021-09-10
65162-0226-21	8 APPLICATOR in 1 CARTON (65162-226-21) / 1 TABLET in 1 APP...	YUVAFEM	Amneal Pharmaceuticals LLC	2016-10-17
65162-0226-23	18 APPLICATOR in 1 CARTON (65162-226-23) / 1 TABLET in 1 AP...	YUVAFEM	Amneal Pharmaceuticals LLC	2016-10-17
68308-0747-00	1 BLISTER PACK in 1 CARTON (68308-747-00) / 2 INSERT in 1 B...	Imvexxy	Mayne Pharma	2024-11-25
68308-0747-08	1 BLISTER PACK in 1 CARTON (68308-747-08) / 8 INSERT in 1 B...	Imvexxy	Mayne Pharma	2024-05-03
68308-0747-18	1 BLISTER PACK in 1 CARTON (68308-747-18) / 18 INSERT in 1...	Imvexxy	Mayne Pharma	2024-06-03
68308-0748-00	1 BLISTER PACK in 1 CARTON (68308-748-00) / 2 INSERT in 1 B...	Imvexxy	Mayne Pharma	2024-05-31
68308-0748-08	1 BLISTER PACK in 1 CARTON (68308-748-08) / 8 INSERT in 1 B...	Imvexxy	Mayne Pharma	2025-01-10
68308-0748-18	1 BLISTER PACK in 1 CARTON (68308-748-18) / 18 INSERT in 1...	Imvexxy	Mayne Pharma	2025-01-10
68462-0711-71	8 APPLICATOR in 1 CARTON (68462-711-71) / 1 TABLET, FILM CO...	ESTRADIOL VAGINAL INSERTS	Glenmark Pharmaceuticals Inc., USA	2018-09-17
68462-0711-88	18 APPLICATOR in 1 CARTON (68462-711-88) / 1 TABLET, FILM C...	ESTRADIOL VAGINAL INSERTS	Glenmark Pharmaceuticals Inc., USA	2018-09-17
72603-0874-08	8 APPLICATOR in 1 CARTON (72603-874-08) / 1 TABLET, FILM CO...	ESTRADIOL VAGINAL INSERTS	NorthStar Rx LLC	2025-09-01
72603-0874-18	18 APPLICATOR in 1 CARTON (72603-874-18) / 1 TABLET, FILM C...	ESTRADIOL VAGINAL INSERTS	NorthStar Rx LLC	2025-09-01

Observed labelers: Mayne Pharma (6) · Novo Nordisk (3) · Amneal Pharmaceuticals LLC (2) · Amneal Pharmaceuticals of New York LLC (2) · Aurobindo Pharma Limited (2) · AvKARE (2) · +5 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7

openFDA export observedJul 14, 2026

RxNorm release07/06/2026

Methodology2026-07-full-catalog-v1

A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.

This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.