Tramadol

Generic name: Pronounced as (tra' ma dole)
Brand names
  • Conzip®
  • Qdolo®
  • Rybix® ODT
  • Ryzolt®
  • Ultram®
  • Ultram® ER
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 01/15/2022

Tramadol may be habit forming, especially with prolonged use. Take tramadol exactly as directed. Do not take more of it, take it more often, or take it in a different way than directed by your doctor. While taking tramadol, discuss with your health care provider your pain treatment goals, length of treatment, and other ways to manage your pain. Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications, or has had an overdose or if you have or have ever had depression or another mental illness. There is a greater risk that you will overuse tramadol if you have or have ever had any of these conditions. Talk to your health care provider immediately and ask for guidance if you think that you have an opioid addiction or call the U.S. Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-HELP.

Tramadol may cause serious or life-threatening breathing problems, especially during the first 24 to 72 hours of your treatment and any time your dose is increased. Your doctor will monitor you carefully during your treatment. Tell your doctor if you have or have ever had slowed breathing or asthma. Your doctor will probably tell you not to take tramadol. Also tell your doctor if you have or have ever had lung disease such as chronic obstructive pulmonary disease (COPD; a group of diseases that affect the lungs and airways), a head injury, brain tumor, or any condition that increases the amount of pressure in your brain. The risk that you will develop breathing problems may be higher if you are an older adult or are weak or malnourished due to disease. If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment: slowed breathing, long pauses between breaths, or shortness of breath.

When tramadol was used in children, serious and life-threatening breathing problems such as slow or difficulty breathing and deaths were reported. Tramadol should never be used to treat pain in children younger than 12 years of age or to relieve pain after surgery to remove the tonsils and/or adenoids in children younger than 18 years of age. Tramadol should also not be used in used in children 12 to 18 years of age who are obese or who have a neuromuscular disease (disease that affects the nerves that control voluntary muscles), a lung disease, or obstructive sleep apnea (condition in which the airway becomes blocked or narrow and breathing stops for short periods during sleep) as these conditions may increase their risk of breathing problems.

Taking certain other medications during your treatment with tramadol may increase the risk that you will experience breathing problems or other serious, life threatening breathing problems, sedation, or coma. Tell your doctor if you are taking or plan to take any of the following medications: amiodarone (Nexterone, Pacerone); certain antifungal medications including itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), and voriconazole (Vfend); benzodiazepines such as alprazolam (Xanax), diazepam (Diastat, Valium), estazolam, flurazepam, lorazepam (Ativan), and triazolam (Halcion); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); erythromycin (Erytab, Erythrocin); certain medications for human immunodeficiency virus (HIV) including indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra); medications for mental illness, nausea, or pain; muscle relaxants; phenytoin (Dilantin, Phenytek); quinidine (in Nuedexta); rifampin (Rifadin, Rimactane, in Rifamate); sedatives; sleeping pills; or tranquilizers. Your doctor may need to change the dosages of your medications and will monitor you carefully. If you take tramadol with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Be sure that your caregiver or family members know which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own.

Drinking alcohol, taking prescription or nonprescription medications that contain alcohol, or using street drugs during your treatment with tramadol increases the risk that you will experience these serious, life-threatening side effects. Do not drink alcohol, take prescription or nonprescription medications that contain alcohol, or use street drugs during your treatment.

Tell your doctor if you are pregnant or plan to become pregnant. If you take tramadol regularly during your pregnancy, your baby may experience life-threatening withdrawal symptoms after birth. Tell your baby's doctor right away if your baby experiences any of the following symptoms: irritability, hyperactivity, abnormal sleep, high-pitched cry, uncontrollable shaking of a part of the body, vomiting, diarrhea, or failure to gain weight.

If you are taking the tramadol extended-release tablet or capsule, swallow them whole; do not chew, break, divide, crush, or dissolve them. Swallow each tablet right after you put it in your mouth. If you swallow broken, chewed, crushed, or dissolved extended-release preparations, you may receive too much tramadol at once instead and this may cause serious problems, including overdose and death.

Do not allow anyone else to take your medication. Tramadol may harm or cause death to other people who take your medication, especially children.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with tramadol and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Tramadol is used to relieve moderate to moderately severe pain. Tramadol extended-release tablets and capsules are only used by people who are expected to need medication to relieve pain around-the-clock. Tramadol is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.

Tramadol comes as a tablet, a solution (liquid), an extended-release (long-acting) tablet, and an extended-release (long-acting) capsule to take by mouth. The regular tablet and solution are taken usually with or without food every 4 to 6 hours as needed. The extended-release tablet and extended-release capsule should be taken once a day. Take the extended-release tablet and the extended-release capsule at about the same time of day every day. If you are taking the extended-release capsule, you may take it with or without food. If you are taking the extended-release tablet, you should either always take it with food or always take it without food. Take tramadol exactly as directed. Do not take more medication as a single dose or take more doses per day than prescribed by your doctor. Taking more tramadol than prescribed by your doctor or in a way that is not recommended may cause serious side effects or death.

Your doctor may start you on a low dose of tramadol and gradually increase the amount of medication you take, not more often than every 3 days if you are taking the solution, regular tablets or orally disintegrating tablets or every 5 days if you are taking the extended-release tablets or extended-release capsules.

If you are taking the solution, use an oral syringe or measuring spoon or cup to measure the correct amount of liquid needed for each dose. Do not use a regular household spoon to measure your dose. Ask your doctor or pharmacist if you need help getting or using a measuring device,

Do not stop taking tramadol without talking to your doctor. Your doctor will probably decrease your dose gradually. If you suddenly stop taking tramadol, you may experience withdrawal symptoms such as nervousness; panic; sweating; difficulty falling asleep or staying asleep; runny nose, sneezing, or cough; pain; hair standing on end; chills; nausea; uncontrollable shaking of a part of your body; diarrhea; or rarely, hallucinations (seeing things or hearing voices that do not exist).

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking tramadol,

  • tell your doctor and pharmacist if you are allergic to tramadol, other opiate pain medications, any other medications, or any of the ingredients in tramadol products. Ask your pharmacist for a list of the ingredients.

  • tell your doctor or pharmacist if you are taking or receiving the following monoamine oxidase (MAO) inhibitors or if you have stopped taking them within the past 2 weeks: isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate). Your doctor will probably tell you not to take tramadol if you are taking one or more of these medications, or have taken them within the past 2 weeks.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); bupropion (Aplenzin, Wellbutrin, Zyban); cyclobenzaprine (Amrix); dextromethorphan (found in many cough medications; in Nuedexta); digoxin (Lanoxin); diuretics ('water pills'); lithium (Lithobid); certain medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, in Treximet), and zolmitriptan (Zomig); mirtazapine (Remeron); promethazine; 5-HT3 receptor antagonists such as alosetron (Lotronex), dolasetron (Anzemet), granisetron (Kytril), ondansetron (Zofran, Zuplenz), or palonosetron (Aloxi); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra), fluvoxamine (Luvox), paroxetine (Paxil, Pexeva), and sertraline (Zoloft); serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Pristiq, Khedezla), duloxetine (Cymbalta), milnacipran (Savella), and venlafaxine (Effexor); trazodone (Oleptro); and tricyclic antidepressants such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor, Zonalon), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil). Many other medications may also interact with tramadol, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor what herbal products you are taking, especially St. John's wort and tryptophan.

  • tell your doctor if you have any of the conditions mentioned in the IMPORTANT WARNING section, a blockage or narrowing of your stomach or intestines, or paralytic ileus (condition in which digested food does not move through the intestines). Your doctor may tell you not to take tramadol if you have any of these conditions.

  • tell your doctor if you have or have ever had seizures; an infection in your brain or spine; difficulty urinating; thoughts about harming or killing yourself or planning or trying to do so; or kidney or liver disease.

  • tell your doctor if you are breastfeeding. You should not breastfeed while taking tramadol. Tramadol can cause shallow breathing, difficulty or noisy breathing, confusion, more than usual sleepiness, trouble breastfeeding, or limpness in breastfed infants.

  • you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of taking tramadol.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking tramadol.

  • you should know that this medication may make you drowsy and may affect your coordination. Do not drive a car or operate machinery until you know how this medication affects you.

  • you should know that tramadol may cause dizziness, lightheadedness, and fainting when you get up from a lying position. To avoid this, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

  • if you have phenylketonuria (PKU; an inherited condition in which a special diet must be followed to prevent damage to your brain that can cause severe intellectual disability, you should know that the orally disintegrating tablets contain aspartame, a source of phenylalanine.

  • you should know that tramadol may cause constipation. Talk to your doctor about changing your diet and using other medications to treat or prevent constipation.

Unless your doctor tells you otherwise, continue your normal diet.

If your doctor has told you to take tramadol regularly, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Tramadol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • sleepiness

    • headache

    • nervousness

    • uncontrollable shaking of a part of the body

    • muscle tightness

    • changes in mood

    • heartburn or indigestion

    • dry mouth

  • Some side effects can be serious. If you experience any of these symptoms or those mentioned in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:

    • hives

    • rash

    • blisters

    • hoarseness

    • difficulty swallowing or breathing

    • swelling of the eyes, face, throat, tongue, lips, hands, feet, ankles, or lower legs

    • agitation, hallucinations (seeing things or hearing voices that do not exist), fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea

    • nausea, vomiting, loss of appetite, weakness, or dizziness

    • changes in heartbeat

    • nausea, vomiting, headache, confusion, loss of energy, drowsiness, fatigue, restlessness, irritability, muscle weakness, spasms or cramps

    • hunger, headache, sweating, shaking of a part of your body that you cannot control, irritability, or difficulty concentrating

    • loss of consciousness

    • seizures

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

  • Tramadol may cause other side effects. Tell your doctor if you have any unusual problems while you are taking this medication.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

While taking tramadol, you should talk to your doctor about having a rescue medication called naloxone readily available (e.g., home, office). Naloxone is used to reverse the life-threatening effects of an overdose. It works by blocking the effects of opiates to relieve dangerous symptoms caused by high levels of opiates in the blood. Your doctor may also prescribe you naloxone if you are living in a household where there are small children or someone who has abused street or prescription drugs. You should make sure that you and your family members, caregivers, or the people who spend time with you know how to recognize an overdose, how to use naloxone, and what to do until emergency medical help arrives. Your doctor or pharmacist will show you and your family members how to use the medication. Ask your pharmacist for the instructions or visit the manufacturer's website to get the instructions. If symptoms of an overdose occur, a friend or family member should give the first dose of naloxone, call 911 immediately, and stay with you and watch you closely until emergency medical help arrives. Your symptoms may return within a few minutes after you receive naloxone. If your symptoms return, the person should give you another dose of naloxone. Additional doses may be given every 2 to 3 minutes, if symptoms return before medical help arrives.

Symptoms of overdose may include the following:

  • decreased size of the pupil (the black circle in the center of the eye)

  • difficulty breathing

  • slow or shallowing breathing

  • extreme drowsiness or sleepiness

  • unable to respond or wake up

  • slowed heartbeat

  • muscle weakness

  • cold, clammy skin

Keep all appointments with your doctor and laboratory. Your doctor may order certain lab tests to check your body's response to tramadol.

Before having any laboratory test (especially those that involve methylene blue), tell your doctor and the laboratory personnel that you are taking tramadol.

Do not let anyone else take your medication. Tramadol is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Ultracet® (containing Acetaminophen, Tramadol)

Drug Interaction
Delavirdine Delavirdine The metabolism of Tramadol can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Nevirapine can be decreased when combined with Tramadol.
Dolasetron Dolasetron The risk or severity of serotonin syndrome can be increased when Dolasetron is combined with Tramadol.
Anagrelide Anagrelide The risk or severity of Tachycardia can be increased when Tramadol is combined with Anagrelide.
Bisacodyl Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Tramadol.
Cilostazol Cilostazol Tramadol may decrease the excretion rate of Cilostazol which could result in a higher serum level.
Clopidogrel Clopidogrel Tramadol can cause a decrease in the absorption of Clopidogrel resulting in a reduced serum concentration and potentially a decrease in efficacy.
Diphenoxylate Diphenoxylate The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Diphenoxylate.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Tramadol can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Tramadol may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate Fenofibrate Tramadol may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Guanfacine Guanfacine The risk or severity of CNS depression can be increased when Guanfacine is combined with Tramadol.
Magnesium Hydroxide Magnesium Hydroxide Tramadol may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Magnesium Oxide Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Tramadol.
Methylergonovine Methylergonovine The metabolism of Tramadol can be decreased when combined with Methylergometrine.
Mycophenolate Mycophenolate Tramadol may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Naratriptan Naratriptan The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Naratriptan.
Olsalazine Olsalazine Olsalazine may decrease the excretion rate of Tramadol which could result in a higher serum level.
Paregoric Paregoric The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Morphine.
Penbutolol Penbutolol The metabolism of Tramadol can be decreased when combined with Acebutolol.
Pentazocine Pentazocine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Pentazocine.
Polyethylene glycol-electrolyte solution (PEG-ES) Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Tramadol.
Potassium Potassium Tramadol may increase the excretion rate of Potassium cation which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone Tramadol may decrease the excretion rate of Prednisone which could result in a higher serum level.
Psyllium Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Tramadol.
Ranitidine Ranitidine The metabolism of Tramadol can be decreased when combined with Ranitidine.
Reserpine Reserpine The risk or severity of CNS depression can be increased when Reserpine is combined with Tramadol.
Rizatriptan Rizatriptan The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Rizatriptan.
Sumatriptan Sumatriptan The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Sumatriptan.
Tacrolimus Tacrolimus The metabolism of Tacrolimus can be decreased when combined with Tramadol.
Tizanidine Tizanidine The risk or severity of CNS depression can be increased when Tizanidine is combined with Tramadol.
Triamcinolone Triamcinolone The metabolism of Tramadol can be increased when combined with Triamcinolone.
Zolmitriptan Zolmitriptan The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Zolmitriptan.
Ampicillin Injection Ampicillin Injection Tramadol may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Tramadol may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection The metabolism of Tramadol can be decreased when combined with Fluconazole.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Tramadol which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Hydromorphone.
Levofloxacin Injection Levofloxacin Injection Tramadol may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Meperidine Injection Meperidine Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Methylprednisolone can be increased when combined with Tramadol.
Metoclopramide Injection Metoclopramide Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Metoclopramide.
Metronidazole Injection Metronidazole Injection The metabolism of Tramadol can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Morphine.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Tramadol which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Tramadol may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The metabolism of Tramadol can be increased when combined with Zidovudine.
Altretamine Altretamine The risk or severity of serotonin syndrome and seizure can be increased when Amphetamine is combined with Tramadol.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Tramadol which could result in a higher serum level.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Tramadol.
Ondansetron Ondansetron The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Ondansetron.
Granisetron Granisetron The risk or severity of serotonin syndrome can be increased when Granisetron is combined with Tramadol.
Torsemide Torsemide The therapeutic efficacy of Torasemide can be decreased when used in combination with Tramadol.
Olanzapine Olanzapine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Olanzapine.
Alosetron Alosetron The risk or severity of CNS depression can be increased when Alosetron is combined with Tramadol.
Entacapone Entacapone The metabolism of Tramadol can be decreased when combined with Entacapone.
Hydroxychloroquine Hydroxychloroquine The metabolism of Tramadol can be decreased when combined with Hydroxychloroquine.
Meloxicam Meloxicam Meloxicam may decrease the excretion rate of Tramadol which could result in a higher serum level.
Orlistat Orlistat The metabolism of Tramadol can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Oxcarbazepine can be decreased when combined with Tramadol.
Pantoprazole Pantoprazole Tramadol may decrease the excretion rate of Pantoprazole which could result in a higher serum level.
Temozolomide Temozolomide Tramadol may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon Zaleplon The risk or severity of CNS depression can be increased when Zaleplon is combined with Tramadol.
Anakinra Anakinra The metabolism of Tramadol can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of CNS depression can be increased when Tramadol is combined with Desloratadine.
Linezolid Linezolid The risk or severity of serotonin syndrome and seizure can be increased when Linezolid is combined with Tramadol.
Rivastigmine Rivastigmine The therapeutic efficacy of Tramadol can be decreased when used in combination with Rivastigmine.
Trimipramine Trimipramine The risk or severity of serotonin syndrome can be increased when Trimipramine is combined with Tramadol.
Etanercept Injection Etanercept Injection The metabolism of Tramadol can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate The risk or severity of adverse effects can be increased when Tramadol is combined with Glycopyrronium.
Modafinil Modafinil The metabolism of Tramadol can be increased when combined with Armodafinil.
Perindopril Perindopril Tramadol may decrease the excretion rate of Perindopril which could result in a higher serum level.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Tramadol which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Tramadol which could result in a higher serum level.
Epinephrine Injection Epinephrine Injection The metabolism of Epinephrine can be decreased when combined with Tramadol.
Eplerenone Eplerenone Eplerenone may increase the excretion rate of Tramadol which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram Escitalopram The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Escitalopram.
Zonisamide Zonisamide The risk or severity of CNS depression can be increased when Zonisamide is combined with Tramadol.
Adalimumab Injection Adalimumab Injection The metabolism of Tramadol can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Aripiprazole.
Atomoxetine Atomoxetine The risk or severity of CNS depression can be increased when Tramadol is combined with Atomoxetine.
Dexmethylphenidate Dexmethylphenidate The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Dexmethylphenidate.
Atazanavir Atazanavir The metabolism of Tramadol can be decreased when combined with Atazanavir.
Almotriptan Almotriptan The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Almotriptan.
Eletriptan Eletriptan The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Eletriptan.
Mefloquine Mefloquine The metabolism of Tramadol can be decreased when combined with Mefloquine.
Polyethylene Glycol 3350 Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Tramadol.
Aprepitant Aprepitant The metabolism of Tramadol can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine Tramadol may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine Memantine The risk or severity of adverse effects can be increased when Tramadol is combined with Memantine.
Tegaserod Tegaserod The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Tegaserod.
Tadalafil Tadalafil Tramadol may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Frovatriptan Frovatriptan The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Frovatriptan.
Progesterone Progesterone The metabolism of Tramadol can be increased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Apomorphine.
Infliximab Injection Infliximab Injection The metabolism of Tramadol can be increased when combined with Infliximab.
Protriptyline Protriptyline The risk or severity of serotonin syndrome can be increased when Protriptyline is combined with Tramadol.
Rifaximin Rifaximin The metabolism of Tramadol can be increased when combined with Rifaximin.
Duloxetine Duloxetine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Duloxetine.
Tinidazole Tinidazole Tramadol may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Trospium Trospium The metabolism of Trospium can be decreased when combined with Tramadol.
Bosentan Bosentan The metabolism of Tramadol can be increased when combined with Bosentan.
Cefditoren Cefditoren Tramadol may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cinacalcet Cinacalcet The metabolism of Tramadol can be decreased when combined with Cinacalcet.
Cyanocobalamin Injection Cyanocobalamin Injection Tramadol may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
Erlotinib Erlotinib The metabolism of Tramadol can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The risk or severity of CNS depression can be increased when Tramadol is combined with Eszopiclone.
Ganciclovir Ganciclovir Tramadol may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Ribavirin Ribavirin Tramadol may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Solifenacin Solifenacin The risk or severity of adverse effects can be increased when Tramadol is combined with Solifenacin.
Valganciclovir Valganciclovir Tramadol may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole Voriconazole The metabolism of Tramadol can be decreased when combined with Voriconazole.
Adefovir Adefovir Adefovir may decrease the excretion rate of Tramadol which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine The risk or severity of serotonin syndrome and seizure can be increased when Amphetamine is combined with Tramadol.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Tramadol can be decreased when combined with Peginterferon alfa-2b.
Pramlintide Injection Pramlintide Injection The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Tramadol.
Sodium Oxybate Sodium Oxybate The risk or severity of CNS depression can be increased when Sodium oxybate is combined with Tramadol.
Isocarboxazid Isocarboxazid The risk or severity of serotonin syndrome and seizure can be increased when Isocarboxazid is combined with Tramadol.
Ramelteon Ramelteon The risk or severity of CNS depression can be increased when Ramelteon is combined with Tramadol.
Darifenacin Darifenacin The metabolism of Darifenacin can be decreased when combined with Tramadol.
Fentanyl Fentanyl The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Fentanyl.
Pregabalin Pregabalin The therapeutic efficacy of Tramadol can be increased when used in combination with Pregabalin.
Deferasirox Deferasirox The metabolism of Tramadol can be increased when combined with Deferasirox.
Phenylephrine Phenylephrine The risk or severity of Tachycardia can be increased when Tramadol is combined with Phenylephrine.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Tramadol.
Felbamate Felbamate The metabolism of Tramadol can be increased when combined with Felbamate.
Ranolazine Ranolazine The metabolism of Tramadol can be decreased when combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Tramadol can be increased when combined with Abatacept.
Rasagiline Rasagiline The risk or severity of serotonin syndrome and seizure can be increased when Rasagiline is combined with Tramadol.
Imatinib Imatinib The metabolism of Tramadol can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin Tramadol may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Varenicline Varenicline Tramadol may decrease the excretion rate of Varenicline which could result in a higher serum level.
Gefitinib Gefitinib The metabolism of Tramadol can be decreased when combined with Gefitinib.
Albuterol Albuterol Tramadol may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone Paliperidone The risk or severity of serotonin syndrome can be increased when Paliperidone is combined with Tramadol.
Bortezomib Bortezomib The metabolism of Tramadol can be decreased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection Tramadol may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Lubiprostone Lubiprostone Tramadol may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Posaconazole Posaconazole The metabolism of Tramadol can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Tramadol can be decreased when combined with Primaquine.
Darunavir Darunavir The metabolism of Darunavir can be decreased when combined with Tramadol.
Pemetrexed Injection Pemetrexed Injection Tramadol may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dimenhydrinate Dimenhydrinate The risk or severity of CNS depression can be increased when Dimenhydrinate is combined with Tramadol.
Lisdexamfetamine Lisdexamfetamine The risk or severity of serotonin syndrome can be increased when Lisdexamfetamine is combined with Tramadol.
Nabilone Nabilone The risk or severity of CNS depression can be increased when Nabilone is combined with Tramadol.
Sorafenib Sorafenib The metabolism of Tramadol can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Tramadol can be decreased when combined with Sunitinib.
Dronabinol Dronabinol The risk or severity of CNS depression can be increased when Dronabinol is combined with Tramadol.
Lapatinib Lapatinib The metabolism of Tramadol can be decreased when combined with Lapatinib.
Levocetirizine Levocetirizine The risk or severity of CNS depression can be increased when Levocetirizine is combined with Tramadol.
Pegaptanib Injection Pegaptanib Injection Tramadol may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Tramadol.
Mexiletine Mexiletine The metabolism of Mexiletine can be decreased when combined with Tramadol.
Armodafinil Armodafinil The metabolism of Tramadol can be increased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection Tramadol may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Paclitaxel (with polyoxyethylated castor oil) Injection Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Tramadol.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Tramadol.
Lenalidomide Lenalidomide Tramadol may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Nilotinib Nilotinib The metabolism of Tramadol can be decreased when combined with Nilotinib.
Bexarotene Bexarotene The metabolism of Tramadol can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Budesonide can be increased when combined with Tramadol.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Tramadol can be decreased when combined with Chloramphenicol.
Desmopressin Desmopressin The risk or severity of hyponatremia can be increased when Tramadol is combined with Desmopressin.
Betaine Betaine The therapeutic efficacy of Tramadol can be decreased when used in combination with Glycine betaine.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Tramadol is combined with Botulinum toxin type A.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of CNS depression can be increased when Tramadol is combined with Botulinum Toxin Type B.
Doripenem Injection Doripenem Injection Tramadol may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine Etravirine The metabolism of Tramadol can be increased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection Tramadol may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Tramadol can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Desvenlafaxine.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Tramadol which could result in a higher serum level.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Tramadol.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Tramadol.
Pilocarpine Pilocarpine The metabolism of Tramadol can be decreased when combined with Pilocarpine.
Flecainide Flecainide The metabolism of Flecainide can be decreased when combined with Tramadol.
Certolizumab Injection Certolizumab Injection The metabolism of Tramadol can be increased when combined with Certolizumab pegol.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Tramadol.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Mitotane Mitotane The metabolism of Tramadol can be increased when combined with Mitotane.
Alvimopan Alvimopan The risk or severity of adverse effects can be increased when Tramadol is combined with Alvimopan.
Methylnaltrexone Injection Methylnaltrexone Injection The therapeutic efficacy of Tramadol can be decreased when used in combination with Methylnaltrexone.
Rufinamide Rufinamide The metabolism of Tramadol can be increased when combined with Rufinamide.
Midazolam Midazolam The metabolism of Midazolam can be decreased when combined with Tramadol.
Naltrexone Injection Naltrexone Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Naltrexone.
Dexrazoxane Injection Dexrazoxane Injection Tramadol may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
Eltrombopag Eltrombopag The metabolism of Tramadol can be decreased when combined with Eltrombopag.
Milnacipran Milnacipran The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Milnacipran.
Plerixafor Injection Plerixafor Injection Tramadol may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Sodium Phosphate Sodium Phosphate The therapeutic efficacy of Sodium phosphate, monobasic can be decreased when used in combination with Tramadol.
Fesoterodine Fesoterodine The risk or severity of adverse effects can be increased when Tramadol is combined with Fesoterodine.
Betaxolol Betaxolol The metabolism of Betaxolol can be decreased when combined with Tramadol.
Iloperidone Iloperidone The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Iloperidone.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Tramadol.
Lacosamide Lacosamide The risk or severity of CNS depression can be increased when Lacosamide is combined with Tramadol.
Everolimus Everolimus The metabolism of Everolimus can be decreased when combined with Tramadol.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Tramadol which could result in a lower serum level and potentially a reduction in efficacy.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Tramadol.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Tramadol is combined with Botulinum toxin type A.
Pralatrexate Injection Pralatrexate Injection Tramadol may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection The risk or severity of serotonin syndrome can be increased when Palonosetron is combined with Tramadol.
Saxagliptin Saxagliptin Tramadol may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection Telavancin Injection Tramadol may decrease the excretion rate of Telavancin which could result in a higher serum level.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Tramadol.
Tapentadol Tapentadol The risk or severity of serotonin syndrome can be increased when Tapentadol is combined with Tramadol.
Topotecan Topotecan The metabolism of Topotecan can be decreased when combined with Tramadol.
Golimumab Injection Golimumab Injection The metabolism of Tramadol can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Tramadol can be decreased when combined with Pazopanib.
Asenapine Asenapine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Asenapine.
Vigabatrin Vigabatrin The risk or severity of CNS depression can be increased when Vigabatrin is combined with Tramadol.
Oxymorphone Oxymorphone The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Oxymorphone.
Tocilizumab Injection Tocilizumab Injection The metabolism of Tramadol can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine The risk or severity of seizure can be increased when Tramadol is combined with Dalfampridine.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Tramadol is combined with Botulinum toxin type A.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Tramadol which could result in a higher serum level.
Lurasidone Lurasidone The risk or severity of serotonin syndrome can be increased when Lurasidone is combined with Tramadol.
Vilazodone Vilazodone The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Vilazodone.
Ipilimumab Injection Ipilimumab Injection Tramadol may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Tramadol can be decreased when combined with Aldesleukin.
Terbutaline Injection Terbutaline Injection The therapeutic efficacy of Tramadol can be decreased when used in combination with Terbutaline.
Roflumilast Roflumilast Tramadol may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Linagliptin Linagliptin The metabolism of Tramadol can be decreased when combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Rilpivirine can be decreased when combined with Tramadol.
Telaprevir Telaprevir The metabolism of Tramadol can be decreased when combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be increased when combined with Tramadol.
Abiraterone Abiraterone The metabolism of Tramadol can be decreased when combined with Abiraterone.
Rivaroxaban Rivaroxaban Tramadol may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor Ticagrelor Tramadol can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Tramadol can be decreased when combined with Brentuximab vedotin.
Ruxolitinib Ruxolitinib Tramadol may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Clobazam Clobazam The metabolism of Clobazam can be decreased when combined with Tramadol.
Vemurafenib Vemurafenib The metabolism of Tramadol can be decreased when combined with Vemurafenib.
Ivacaftor Ivacaftor The metabolism of Tramadol can be decreased when combined with Ivacaftor.
Deferiprone Deferiprone Tramadol may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Crizotinib Crizotinib The metabolism of Tramadol can be decreased when combined with Crizotinib.
Cabergoline Cabergoline The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Naloxone can be decreased when combined with Tramadol.
Fondaparinux Injection Fondaparinux Injection Tramadol may decrease the excretion rate of Fondaparinux which could result in a higher serum level.
Ezogabine Ezogabine The risk or severity of CNS depression can be increased when Tiagabine is combined with Tramadol.
Enzalutamide Enzalutamide The metabolism of Tramadol can be increased when combined with Enzalutamide.
Mirabegron Mirabegron The risk or severity of urinary retention can be increased when Tramadol is combined with Mirabegron.
Regorafenib Regorafenib The metabolism of Tramadol can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Tramadol can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Tramadol can be increased when combined with Corticotropin.
Linaclotide Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Tramadol.
Teduglutide Injection Teduglutide Injection Tramadol may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Alogliptin Alogliptin Tramadol may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Tramadol.
Pomalidomide Pomalidomide The risk or severity of CNS depression can be increased when Tramadol is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Tramadol.
Canagliflozin Canagliflozin Tramadol may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide Methazolamide The therapeutic efficacy of Methazolamide can be decreased when used in combination with Tramadol.
Dabrafenib Dabrafenib The metabolism of Dabrafenib can be increased when combined with Tramadol.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Tramadol.
Trametinib Trametinib The metabolism of Trametinib can be increased when combined with Tramadol.
Levomilnacipran Levomilnacipran The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Levomilnacipran.
Ertapenem Injection Ertapenem Injection Tramadol may decrease the excretion rate of Ertapenem which could result in a higher serum level.
Vortioxetine Vortioxetine The risk or severity of serotonin syndrome can be increased when Vortioxetine is combined with Tramadol.
Perampanel Perampanel The metabolism of Tramadol can be increased when combined with Perampanel.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Tramadol.
Lomitapide Lomitapide The metabolism of Lomitapide can be decreased when combined with Tramadol.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the excretion rate of Tramadol which could result in a higher serum level.
Simeprevir Simeprevir The metabolism of Tramadol can be decreased when combined with Simeprevir.
Sofosbuvir Sofosbuvir Tramadol may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin Tramadol may increase the excretion rate of Dapagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast Apremilast The metabolism of Tramadol can be increased when combined with Apremilast.
Droxidopa Droxidopa Tramadol may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib Ceritinib The metabolism of Ceritinib can be decreased when combined with Tramadol.
Siltuximab Injection Siltuximab Injection The metabolism of Tramadol can be decreased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Tramadol can be increased when combined with Eslicarbazepine.
Idelalisib Idelalisib The metabolism of Tramadol can be decreased when combined with Idelalisib.
Testosterone Injection Testosterone Injection The metabolism of Tramadol can be increased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Tramadol can be increased when combined with Oritavancin.
Hydrocodone Hydrocodone The risk or severity of serotonin syndrome can be increased when Hydrocodone is combined with Tramadol.
Suvorexant Suvorexant Tramadol may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Edoxaban Edoxaban Tramadol may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Tramadol.
Methamphetamine Methamphetamine The risk or severity of serotonin syndrome can be increased when Metamfetamine is combined with Tramadol.
Tasimelteon Tasimelteon The risk or severity of CNS depression can be increased when Tasimelteon is combined with Tramadol.
Lanreotide Injection Lanreotide Injection The metabolism of Tramadol can be decreased when combined with Lanreotide.
Secukinumab Injection Secukinumab Injection The metabolism of Tramadol can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Risperidone.
Palbociclib Palbociclib The metabolism of Tramadol can be decreased when combined with Palbociclib.
Lenvatinib Lenvatinib The metabolism of Tramadol can be decreased when combined with Lenvatinib.
Naloxegol Naloxegol The metabolism of Tramadol can be decreased when combined with Naloxegol.
Panobinostat Panobinostat The metabolism of Tramadol can be decreased when combined with Panobinostat.
Haloperidol Injection Haloperidol Injection The metabolism of Haloperidol can be decreased when combined with Tramadol.
Amiloride Amiloride The therapeutic efficacy of Amiloride can be decreased when used in combination with Tramadol.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Tramadol can be decreased when combined with Isavuconazonium.
Macitentan Macitentan Tramadol may decrease the excretion rate of Macitentan which could result in a higher serum level.
Flibanserin Flibanserin The risk or severity of serotonin syndrome can be increased when Flibanserin is combined with Tramadol.
Rolapitant Rolapitant The metabolism of Tramadol can be decreased when combined with Rolapitant.
Prednisolone Prednisolone The metabolism of Prednisolone can be increased when combined with Tramadol.
Brexpiprazole Brexpiprazole The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Ziprasidone.
Cariprazine Cariprazine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Cariprazine.
Penicillin G Procaine Injection Penicillin G Procaine Injection Tramadol may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline Eluxadoline The risk or severity of constipation can be increased when Tramadol is combined with Eluxadoline.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Tramadol.
Osimertinib Osimertinib The metabolism of Osimertinib can be decreased when combined with Tramadol.
Ixazomib Ixazomib Tramadol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Rifapentine Rifapentine The metabolism of Tramadol can be increased when combined with Rifapentine.
Lesinurad Lesinurad Tramadol may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Tramadol can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Tramadol can be decreased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The risk or severity of CNS depression can be increased when Brivaracetam is combined with Tramadol.
Venetoclax Venetoclax The metabolism of Tramadol can be decreased when combined with Venetoclax.
Cobicistat Cobicistat The metabolism of Tramadol can be decreased when combined with Cobicistat.
Midodrine Midodrine The risk or severity of Tachycardia can be increased when Tramadol is combined with Midodrine.
Pimavanserin Pimavanserin The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Pimavanserin.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Diphenhydramine.
Furosemide Injection Furosemide Injection Tramadol may increase the excretion rate of Furosemide which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib Rucaparib The metabolism of Tramadol can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection Tramadol may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ribociclib Ribociclib The metabolism of Tramadol can be decreased when combined with Ribociclib.
Brigatinib Brigatinib The metabolism of Tramadol can be increased when combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) The risk or severity of serotonin syndrome can be increased when Doxepin is combined with Tramadol.
Plecanatide Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Tramadol.
Deutetrabenazine Deutetrabenazine Tramadol may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Tramadol may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Safinamide Safinamide The risk or severity of serotonin syndrome and seizure can be increased when Safinamide is combined with Tramadol.
Naldemedine Naldemedine The therapeutic efficacy of Tramadol can be decreased when used in combination with Naldemedine.
Sarilumab Injection Sarilumab Injection The metabolism of Tramadol can be decreased when combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Tramadol can be decreased when combined with Midostaurin.
Enasidenib Enasidenib The metabolism of Tramadol can be decreased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Tramadol can be decreased when combined with Fosaprepitant.
Benznidazole Benznidazole Tramadol may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin The metabolism of Delafloxacin can be increased when combined with Tramadol.
Acalabrutinib Acalabrutinib The metabolism of Tramadol can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Tramadol can be decreased when combined with Letermovir.
Tetrabenazine Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Tramadol.
Ertugliflozin Ertugliflozin The metabolism of Tramadol can be decreased when combined with Ertugliflozin.
Buprenorphine Injection Buprenorphine Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Buprenorphine.
Apalutamide Apalutamide The metabolism of Apalutamide can be increased when combined with Tramadol.
Fostamatinib Fostamatinib The metabolism of Tramadol can be decreased when combined with Fostamatinib.
Baricitinib Baricitinib Tramadol may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine The risk or severity of serotonin syndrome can be increased when Lofexidine is combined with Tramadol.
Plazomicin Injection Plazomicin Injection Tramadol may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat Eliglustat The metabolism of Tramadol can be decreased when combined with Eliglustat.
Encorafenib Encorafenib The metabolism of Encorafenib can be decreased when combined with Tramadol.
Ivosidenib Ivosidenib The metabolism of Tramadol can be increased when combined with Ivosidenib.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Tramadol.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Tramadol.
Cannabidiol Cannabidiol The risk or severity of serotonin syndrome can be increased when Cannabidiol is combined with Tramadol.
Dacomitinib Dacomitinib The metabolism of Tramadol can be decreased when combined with Dacomitinib.
Stiripentol Stiripentol The metabolism of Tramadol can be decreased when combined with Stiripentol.
Gilteritinib Gilteritinib The therapeutic efficacy of Tramadol can be decreased when used in combination with Gilteritinib.
Lorlatinib Lorlatinib The metabolism of Tramadol can be increased when combined with Lorlatinib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Tramadol.
Rifamycin Rifamycin The metabolism of Tramadol can be decreased when combined with Rifamycin.
Prucalopride Prucalopride Tramadol may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Magnesium Citrate Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Tramadol.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Tramadol can be increased when combined with Emapalumab.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Tramadol which could result in a higher serum level.
Alpelisib Alpelisib The metabolism of Tramadol can be decreased when combined with Alpelisib.
Brexanolone Injection Brexanolone Injection The risk or severity of CNS depression can be increased when Brexanolone is combined with Tramadol.
Solriamfetol Solriamfetol The risk or severity of Tachycardia can be increased when Solriamfetol is combined with Tramadol.
Triclabendazole Triclabendazole The metabolism of Tramadol can be decreased when combined with Triclabendazole.
Pexidartinib Pexidartinib The metabolism of Tramadol can be decreased when combined with Pexidartinib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Tramadol.
Pitolisant Pitolisant The serum concentration of Tramadol can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The metabolism of Tramadol can be decreased when combined with Fedratinib.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be increased when combined with Tramadol.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Tramadol can be increased when combined with Fosphenytoin.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Tramadol.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Tramadol.
Lumateperone Lumateperone The risk or severity of CNS depression can be increased when Lumateperone is combined with Tramadol.
Lasmiditan Lasmiditan The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Lasmiditan.
Cenobamate Cenobamate The serum concentration of Cenobamate can be decreased when it is combined with Tramadol.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Tramadol.
Remdesivir Injection Remdesivir Injection The metabolism of Tramadol can be decreased when combined with Remdesivir.
Lemborexant Lemborexant The serum concentration of Tramadol can be decreased when it is combined with Lemborexant.
Fenfluramine Fenfluramine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Fenfluramine.
Octreotide Octreotide The metabolism of Tramadol can be decreased when combined with Octreotide.
Pralsetinib Pralsetinib The metabolism of Tramadol can be decreased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Tramadol can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The therapeutic efficacy of Drospirenone can be decreased when used in combination with Tramadol.
Viloxazine Viloxazine The risk or severity of CNS depression can be increased when Tramadol is combined with Viloxazine.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Tramadol can be increased when combined with Vitamin E.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Tramadol.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Tramadol which could result in a higher serum level.
Indomethacin Indomethacin Indomethacin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid Mefenamic acid may decrease the excretion rate of Tramadol which could result in a higher serum level.
Naproxen Naproxen Naproxen may decrease the excretion rate of Tramadol which could result in a higher serum level.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Tramadol which could result in a higher serum level.
Trazodone Trazodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Tramadol.
Isotretinoin Isotretinoin Tramadol may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Tramadol may decrease the excretion rate of Sucralfate which could result in a higher serum level.
Hydroxyurea Hydroxyurea The metabolism of Tramadol can be decreased when combined with Hydroxyurea.
Floxuridine Floxuridine Tramadol may decrease the excretion rate of Floxuridine which could result in a higher serum level.
Phenobarbital Phenobarbital The metabolism of Phenobarbital can be increased when combined with Tramadol.
Metaxalone Metaxalone The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Metaxalone.
Methotrexate Injection Methotrexate Injection Methotrexate may decrease the excretion rate of Tramadol which could result in a higher serum level.
Levorphanol Levorphanol The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Levorphanol.
Primidone Primidone The metabolism of Tramadol can be increased when combined with Primidone.
Methsuximide Methsuximide The risk or severity of CNS depression can be increased when Methsuximide is combined with Tramadol.
Diethylpropion Diethylpropion The risk or severity of serotonin syndrome can be increased when Diethylpropion is combined with Tramadol.
Chlorpromazine Chlorpromazine The risk or severity of serotonin syndrome can be increased when Chlorpromazine is combined with Tramadol.
Diazepam Diazepam The metabolism of Diazepam can be decreased when combined with Tramadol.
Oxazepam Oxazepam The risk or severity of CNS depression can be increased when Tramadol is combined with Oxazepam.
Flurazepam Flurazepam The risk or severity of CNS depression can be increased when Tramadol is combined with Flurazepam.
Clorazepate Clorazepate The risk or severity of CNS depression can be increased when Tramadol is combined with Clorazepic acid.
Lorazepam Lorazepam The risk or severity of CNS depression can be increased when Tramadol is combined with Lorazepam.
Carmustine Carmustine Tramadol may decrease the excretion rate of Carmustine which could result in a higher serum level.
Amantadine Amantadine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Amantadine.
Codeine Codeine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Codeine.
Meprobamate Meprobamate The risk or severity of CNS depression can be increased when Meprobamate is combined with Tramadol.
Chlordiazepoxide Chlordiazepoxide The risk or severity of CNS depression can be increased when Tramadol is combined with Chlordiazepoxide.
Bromocriptine Bromocriptine The metabolism of Bromocriptine can be decreased when combined with Tramadol.
Metaproterenol Metaproterenol The risk or severity of Tachycardia can be increased when Tramadol is combined with Orciprenaline.
Tranylcypromine Tranylcypromine The risk or severity of serotonin syndrome and seizure can be increased when Tranylcypromine is combined with Tramadol.
Phenelzine Phenelzine The risk or severity of serotonin syndrome and seizure can be increased when Phenelzine is combined with Tramadol.
Procarbazine Procarbazine The risk or severity of serotonin syndrome and seizure can be increased when Procarbazine is combined with Tramadol.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Ergoloid mesylate.
Tetracycline Tetracycline The metabolism of Tetracycline can be decreased when combined with Tramadol.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Tramadol.
Prochlorperazine Prochlorperazine The risk or severity of CNS depression can be increased when Prochlorperazine is combined with Tramadol.
Thioridazine Thioridazine The risk or severity of serotonin syndrome can be increased when Thioridazine is combined with Tramadol.
Trifluoperazine Trifluoperazine The risk or severity of CNS depression can be increased when Trifluoperazine is combined with Tramadol.
Bleomycin Bleomycin Tramadol may decrease the excretion rate of Bleomycin which could result in a higher serum level.
Sulfadiazine Sulfadiazine Tramadol may decrease the excretion rate of Sulfadiazine which could result in a higher serum level.
Oxycodone Oxycodone The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Oxycodone.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Tramadol.
Oxybutynin Oxybutynin The metabolism of Tramadol can be decreased when combined with Oxybutynin.
Benztropine Benztropine The risk or severity of adverse effects can be increased when Tramadol is combined with Benzatropine.
Maprotiline Maprotiline The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Maprotiline.
Ibuprofen Ibuprofen Ibuprofen may decrease the excretion rate of Tramadol which could result in a higher serum level.
Trihexyphenidyl Trihexyphenidyl The risk or severity of adverse effects can be increased when Tramadol is combined with Trihexyphenidyl.
Orphenadrine Orphenadrine The metabolism of Orphenadrine can be decreased when combined with Tramadol.
Perphenazine Perphenazine The metabolism of Tramadol can be decreased when combined with Perphenazine.
Azathioprine Azathioprine Tramadol may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Fluphenazine Fluphenazine The metabolism of Tramadol can be decreased when combined with Fluphenazine.
Phentermine Phentermine The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Tramadol.
Methylphenidate Methylphenidate Tramadol may decrease the excretion rate of Methylphenidate which could result in a higher serum level.
Amoxapine Amoxapine The risk or severity of serotonin syndrome can be increased when Amoxapine is combined with Tramadol.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Tramadol which could result in a higher serum level.
Hydrocortisone Hydrocortisone The metabolism of Hydrocortisone can be increased when combined with Tramadol.
Doxorubicin Doxorubicin The metabolism of Tramadol can be decreased when combined with Doxorubicin.
Mechlorethamine Mechlorethamine The therapeutic efficacy of Tramadol can be decreased when used in combination with Mechlorethamine.
Pyridostigmine Pyridostigmine The therapeutic efficacy of Tramadol can be decreased when used in combination with Pyridostigmine.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Tramadol which could result in a higher serum level.
Carbamazepine Carbamazepine The therapeutic efficacy of Carbamazepine can be decreased when used in combination with Tramadol.
Molindone Molindone The risk or severity of CNS depression can be increased when Molindone is combined with Tramadol.
Methyldopa Methyldopa Tramadol may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Tramadol.
Hydralazine Hydralazine The metabolism of Hydralazine can be decreased when combined with Tramadol.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Warfarin Warfarin The therapeutic efficacy of Warfarin can be increased when used in combination with Tramadol.
Clonazepam Clonazepam The risk or severity of CNS depression can be increased when Tramadol is combined with Clonazepam.
Loperamide Loperamide The metabolism of Tramadol can be decreased when combined with Loperamide.
Promethazine Promethazine The risk or severity of serotonin syndrome can be increased when Promethazine is combined with Tramadol.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the excretion rate of Tramadol which could result in a higher serum level.
Daunorubicin Daunorubicin The metabolism of Tramadol can be decreased when combined with Daunorubicin.
Nitrofurantoin Nitrofurantoin Tramadol may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Tramadol can be increased when combined with Griseofulvin.
Digoxin Digoxin The risk or severity of adverse effects can be increased when Tramadol is combined with Digoxin.
Loxapine Loxapine The risk or severity of serotonin syndrome can be increased when Loxapine is combined with Tramadol.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Tramadol.
Quinine Quinine The metabolism of Tramadol can be decreased when combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of CNS depression can be increased when Ethosuximide is combined with Tramadol.
Calcitriol Calcitriol The metabolism of Tramadol can be increased when combined with Calcitriol.
Triamterene Triamterene The therapeutic efficacy of Triamterene can be decreased when used in combination with Tramadol.
Lactulose Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Tramadol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Tramadol can be increased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Tramadol.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Tramadol.
Metolazone Metolazone Tramadol may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide The therapeutic efficacy of Isosorbide can be decreased when used in combination with Tramadol.
Secobarbital Secobarbital The metabolism of Tramadol can be increased when combined with Secobarbital.
Desipramine Desipramine The risk or severity of serotonin syndrome can be increased when Desipramine is combined with Tramadol.
Amitriptyline Amitriptyline The risk or severity of serotonin syndrome can be increased when Amitriptyline is combined with Tramadol.
Imipramine Imipramine The risk or severity of serotonin syndrome can be increased when Imipramine is combined with Tramadol.
Probenecid Probenecid The metabolism of Tramadol can be increased when combined with Probenecid.
Quinidine Quinidine The metabolism of Quinidine can be decreased when combined with Tramadol.
Procainamide Procainamide The metabolism of Procainamide can be decreased when combined with Tramadol.
Isoniazid Isoniazid The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Isoniazid.
Pyrazinamide Pyrazinamide Tramadol may decrease the excretion rate of Pyrazinamide which could result in a higher serum level.
Rifampin Rifampin The metabolism of Tramadol can be increased when combined with Rifampicin.
Disopyramide Disopyramide The risk or severity of adverse effects can be increased when Tramadol is combined with Disopyramide.
Valproic Acid Valproic Acid The risk or severity of serotonin syndrome can be increased when Valproic acid is combined with Tramadol.
Tamoxifen Tamoxifen The metabolism of Tramadol can be decreased when combined with Tamoxifen.
Butabarbital Butabarbital The risk or severity of CNS depression can be increased when Butabarbital is combined with Tramadol.
Liothyronine Liothyronine Tramadol may decrease the excretion rate of Liothyronine which could result in a higher serum level.
Methimazole Methimazole The metabolism of Tramadol can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide Tramadol may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
Glucagon Injection Glucagon Injection Tramadol may increase the gastrointestinal motility reducing activities of Glucagon.
Tolbutamide Tolbutamide Tramadol may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolazamide Tolazamide Tramadol may decrease the excretion rate of Tolazamide which could result in a higher serum level.
Dextromethorphan Dextromethorphan The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Dextromethorphan.
Cyclobenzaprine Cyclobenzaprine The risk or severity of serotonin syndrome and seizure can be increased when Cyclobenzaprine is combined with Tramadol.
Niacin Niacin The metabolism of Tramadol can be decreased when combined with Niacin.
Baclofen Baclofen The risk or severity of CNS depression can be increased when Baclofen is combined with Tramadol.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Tramadol.
Cyproheptadine Cyproheptadine The risk or severity of CNS depression can be increased when Tramadol is combined with Cyproheptadine.
Clemastine Clemastine The metabolism of Tramadol can be decreased when combined with Clemastine.
Chlorpheniramine Chlorpheniramine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Chlorpheniramine.
Brompheniramine Brompheniramine The risk or severity of CNS depression can be increased when Tramadol is combined with Brompheniramine.
Meclizine Meclizine The risk or severity of CNS depression can be increased when Meclizine is combined with Tramadol.
Ethambutol Ethambutol Tramadol may decrease the excretion rate of Ethambutol which could result in a higher serum level.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Tramadol.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Tramadol.
Dantrolene Dantrolene The risk or severity of CNS depression can be increased when Dantrolene is combined with Tramadol.
Chlorzoxazone Chlorzoxazone The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Tramadol.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Tramadol.
Methocarbamol Methocarbamol The risk or severity of CNS depression can be increased when Methocarbamol is combined with Tramadol.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Tramadol which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Tramadol which could result in a higher serum level.
Danazol Danazol The metabolism of Tramadol can be decreased when combined with Danazol.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Tramadol can be decreased when combined with Propranolol.
Pseudoephedrine Pseudoephedrine The risk or severity of serotonin syndrome can be increased when Pseudoephedrine is combined with Tramadol.
Nortriptyline Nortriptyline The risk or severity of serotonin syndrome can be increased when Nortriptyline is combined with Tramadol.
Spironolactone Spironolactone The therapeutic efficacy of Spironolactone can be decreased when used in combination with Tramadol.
Amphotericin B Injection Amphotericin B Injection The metabolism of Tramadol can be decreased when combined with Amphotericin B.
Phytonadione Phytonadione Tramadol may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Nadolol Nadolol Tramadol may decrease the excretion rate of Nadolol which could result in a higher serum level.
Butorphanol Injection Butorphanol Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Butorphanol.
Nalbuphine Injection Nalbuphine Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Nalbuphine.
Allopurinol Allopurinol Tramadol may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Trimethobenzamide Trimethobenzamide The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Tramadol.
Flavoxate Flavoxate The risk or severity of adverse effects can be increased when Tramadol is combined with Flavoxate.
Colchicine Colchicine The metabolism of Tramadol can be decreased when combined with Colchicine.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Tramadol which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Tramadol which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Dacarbazine Dacarbazine Tramadol may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Acetazolamide Acetazolamide The metabolism of Tramadol can be decreased when combined with Acetazolamide.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Tramadol which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Ketoconazole Ketoconazole The metabolism of Tramadol can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel The risk or severity of CNS depression can be increased when Pyrantel is combined with Tramadol.
Thiotepa Injection Thiotepa Injection The metabolism of Tramadol can be decreased when combined with Thiotepa.
Isoxsuprine Isoxsuprine The risk or severity of Tachycardia can be increased when Tramadol is combined with Isoxsuprine.
Vinblastine Vinblastine The metabolism of Tramadol can be decreased when combined with Vinblastine.
Ethacrynic Acid Ethacrynic Acid The therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Tramadol.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Tramadol which could result in a higher serum level.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Tramadol.
Hydroxyzine Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tramadol.
Thiothixene Thiothixene The metabolism of Tramadol can be decreased when combined with Thiothixene.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Tramadol which could result in a higher serum level.
Salsalate Salsalate Salsalate may decrease the excretion rate of Tramadol which could result in a higher serum level.
Alprazolam Alprazolam The risk or severity of CNS depression can be increased when Tramadol is combined with Alprazolam.
Temazepam Temazepam The risk or severity of CNS depression can be increased when Tramadol is combined with Temazepam.
Triazolam Triazolam The risk or severity of CNS depression can be increased when Tramadol is combined with Triazolam.
Dicyclomine Dicyclomine The risk or severity of adverse effects can be increased when Tramadol is combined with Dicyclomine.
Hyoscyamine Hyoscyamine The risk or severity of adverse effects can be increased when Tramadol is combined with Hyoscyamine.
Propantheline Propantheline The risk or severity of adverse effects can be increased when Tramadol is combined with Propantheline.
Trimethoprim Trimethoprim Tramadol may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Diltiazem Diltiazem The metabolism of Tramadol can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Nifedipine can be increased when combined with Tramadol.
Timolol Timolol Tramadol may decrease the excretion rate of Timolol which could result in a higher serum level.
Verapamil Verapamil The metabolism of Tramadol can be decreased when combined with Verapamil.
Atenolol Atenolol The metabolism of Atenolol can be decreased when combined with Tramadol.
Pindolol Pindolol The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Pindolol.
Cisplatin Injection Cisplatin Injection Cisplatin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Diflunisal Diflunisal Diflunisal may decrease the excretion rate of Tramadol which could result in a higher serum level.
Piroxicam Piroxicam Piroxicam may decrease the excretion rate of Tramadol which could result in a higher serum level.
Bumetanide Bumetanide Tramadol may increase the excretion rate of Bumetanide which could result in a lower serum level and potentially a reduction in efficacy.
Etoposide Etoposide The metabolism of Tramadol can be decreased when combined with Etoposide.
Glyburide Glyburide The metabolism of Tramadol can be decreased when combined with Glyburide.
Glipizide Glipizide Tramadol may decrease the excretion rate of Glipizide which could result in a higher serum level.
Indapamide Indapamide Tramadol may increase the excretion rate of Indapamide which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin Amoxicillin Tramadol may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Dicloxacillin Dicloxacillin The metabolism of Tramadol can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Tramadol can be increased when combined with Nafcillin.
Oxacillin Injection Oxacillin Injection Tramadol may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline Pentoxifylline Tramadol may decrease the excretion rate of Pentoxifylline which could result in a higher serum level.
Pentamidine Injection Pentamidine Injection Pentamidine may decrease the excretion rate of Tramadol which could result in a higher serum level.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Tramadol which could result in a higher serum level.
Labetalol Labetalol The metabolism of Tramadol can be decreased when combined with Labetalol.
Auranofin Auranofin Tramadol may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Leuprolide may decrease the excretion rate of Tramadol which could result in a higher serum level.
Gemfibrozil Gemfibrozil The metabolism of Tramadol can be decreased when combined with Gemfibrozil.
Guanabenz Guanabenz The risk or severity of Tachycardia can be increased when Tramadol is combined with Guanabenz.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Tramadol which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Tramadol which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Tramadol which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Tramadol which could result in a higher serum level.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Tramadol.
Flurbiprofen Flurbiprofen The metabolism of Tramadol can be decreased when combined with Flurbiprofen.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Tramadol.
Aztreonam Injection Aztreonam Injection Tramadol may decrease the excretion rate of Aztreonam which could result in a higher serum level.
Buspirone Buspirone The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Buspirone.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Tramadol.
Ciprofloxacin Ciprofloxacin The metabolism of Ciprofloxacin can be decreased when combined with Tramadol.
Mesalamine Mesalamine Mesalazine may decrease the excretion rate of Tramadol which could result in a higher serum level.
Diclofenac Diclofenac Diclofenac may decrease the excretion rate of Tramadol which could result in a higher serum level.
Fluoxetine Fluoxetine The risk or severity of serotonin syndrome can be increased when Fluoxetine is combined with Tramadol.
Clozapine Clozapine The metabolism of Clozapine can be decreased when combined with Tramadol.
Estazolam Estazolam The risk or severity of CNS depression can be increased when Tramadol is combined with Estazolam.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Tramadol.
Didanosine Didanosine Tramadol may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Tramadol may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Clarithromycin Clarithromycin The metabolism of Tramadol can be decreased when combined with Clarithromycin.
Etodolac Etodolac Etodolac may decrease the excretion rate of Tramadol which could result in a higher serum level.
Felodipine Felodipine The metabolism of Felodipine can be decreased when combined with Tramadol.
Fosinopril Fosinopril Tramadol may decrease the excretion rate of Fosinopril which could result in a higher serum level.
Nabumetone Nabumetone Nabumetone may decrease the excretion rate of Tramadol which could result in a higher serum level.
Simvastatin Simvastatin The metabolism of Simvastatin can be increased when combined with Tramadol.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be decreased when combined with Tramadol.
Itraconazole Itraconazole The metabolism of Tramadol can be decreased when combined with Itraconazole.
Lisinopril Lisinopril Tramadol may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Rifabutin Rifabutin The metabolism of Tramadol can be increased when combined with Rifabutin.
Sotalol Sotalol The metabolism of Sotalol can be decreased when combined with Tramadol.
Bisoprolol Bisoprolol Tramadol may decrease the excretion rate of Bisoprolol which could result in a higher serum level.
Zolpidem Zolpidem Tramadol may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Tramadol.
Isradipine Isradipine The metabolism of Tramadol can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Tramadol can be decreased when combined with Omeprazole.
Cisapride Cisapride The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Cisapride.
Gabapentin Gabapentin The risk or severity of CNS depression can be increased when Gabapentin is combined with Tramadol.
Fluvastatin Fluvastatin The metabolism of Tramadol can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The risk or severity of serotonin syndrome can be increased when Venlafaxine is combined with Tramadol.
Nizatidine Nizatidine The therapeutic efficacy of Tramadol can be decreased when used in combination with Nizatidine.
Fluvoxamine Fluvoxamine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Fluvoxamine.
Nefazodone Nefazodone The risk or severity of serotonin syndrome can be increased when Nefazodone is combined with Tramadol.
Lamotrigine Lamotrigine The risk or severity of CNS depression can be increased when Lamotrigine is combined with Tramadol.
Losartan Losartan The metabolism of Tramadol can be decreased when combined with Losartan.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Tramadol which could result in a higher serum level.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Tramadol.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Lansoprazole Lansoprazole The metabolism of Tramadol can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Tramadol.
Nicardipine Nicardipine The metabolism of Tramadol can be decreased when combined with Nicardipine.
Bupropion Bupropion The risk or severity of seizure can be increased when Bupropion is combined with Tramadol.
Ticlopidine Ticlopidine The metabolism of Tramadol can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Saquinavir can be decreased when combined with Tramadol.
Metformin Metformin Tramadol may decrease the excretion rate of Metformin which could result in a higher serum level.
Nisoldipine Nisoldipine Tramadol may decrease the excretion rate of Nisoldipine which could result in a higher serum level.
Lamivudine Lamivudine Tramadol may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole The risk or severity of CNS depression can be increased when Riluzole is combined with Tramadol.
Acarbose Acarbose Tramadol may decrease the excretion rate of Acarbose which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection Tramadol may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Indinavir Indinavir The metabolism of Indinavir can be decreased when combined with Tramadol.
Ritonavir Ritonavir The serum concentration of Tramadol can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Tramadol.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Tramadol which could result in a higher serum level.
Meropenem Injection Meropenem Injection Tramadol may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine Clomipramine The risk or severity of serotonin syndrome can be increased when Clomipramine is combined with Tramadol.
Zafirlukast Zafirlukast The metabolism of Tramadol can be decreased when combined with Zafirlukast.
Fosfomycin Fosfomycin Tramadol may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine Mirtazapine Tramadol may increase the serotonergic activities of Mirtazapine.
Topiramate Topiramate The risk or severity of hyperthermia and oligohydrosis can be increased when Tramadol is combined with Topiramate.
Pramipexole Pramipexole Tramadol may increase the sedative activities of Pramipexole.
Donepezil Donepezil The therapeutic efficacy of Tramadol can be decreased when used in combination with Donepezil.
Nelfinavir Nelfinavir The metabolism of Nelfinavir can be decreased when combined with Tramadol.
Loratadine Loratadine Tramadol may increase the anticholinergic activities of Loratadine.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Tramadol.
Nilutamide Nilutamide Tramadol may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Flutamide Flutamide Tramadol may decrease the excretion rate of Flutamide which could result in a higher serum level.
Selegiline Selegiline The risk or severity of serotonin syndrome and seizure can be increased when Selegiline is combined with Tramadol.
Bicalutamide Bicalutamide The metabolism of Tramadol can be decreased when combined with Bicalutamide.
Sertraline Sertraline The risk or severity of serotonin syndrome can be increased when Sertraline is combined with Tramadol.
Propafenone Propafenone The metabolism of Tramadol can be decreased when combined with Propafenone.
Raloxifene Raloxifene The metabolism of Tramadol can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Tramadol can be decreased when combined with Irbesartan.
Tamsulosin Tamsulosin Tramadol may decrease the excretion rate of Tamsulosin which could result in a higher serum level.
Ropinirole Ropinirole The risk or severity of CNS depression can be increased when Tramadol is combined with Ropinirole.
Quetiapine Quetiapine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Quetiapine.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Tramadol which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Tramadol which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Tramadol which could result in a higher serum level.
Cetirizine Cetirizine The risk or severity of CNS depression can be increased when Cetirizine is combined with Tramadol.
Paroxetine Paroxetine The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Tramadol.
Tolcapone Tolcapone The risk or severity of CNS depression can be increased when Tolcapone is combined with Tramadol.
Citalopram Citalopram The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Citalopram.
Capecitabine Capecitabine Tramadol may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Efavirenz Efavirenz The metabolism of Tramadol can be decreased when combined with Efavirenz.
Abacavir Abacavir Tramadol may decrease the excretion rate of Abacavir which could result in a higher serum level.
Sildenafil Sildenafil The metabolism of Sildenafil can be decreased when combined with Tramadol.
Celecoxib Celecoxib The metabolism of Tramadol can be decreased when combined with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Tramadol can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine The risk or severity of adverse effects can be increased when Tramadol is combined with Tolterodine.
Thalidomide Thalidomide Tramadol may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir Oseltamivir Tramadol may decrease the excretion rate of Oseltamivir which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may decrease the excretion rate of Tramadol which could result in a higher serum level.
Nateglinide Nateglinide Tramadol may decrease the excretion rate of Nateglinide which could result in a higher serum level.
Galantamine Galantamine The therapeutic efficacy of Tramadol can be decreased when used in combination with Galantamine.
Levetiracetam Levetiracetam The risk or severity of CNS depression can be increased when Tramadol is combined with Levetiracetam.
Rabeprazole Rabeprazole The metabolism of Rabeprazole can be decreased when combined with Tramadol.
Terbinafine Terbinafine The metabolism of Tramadol can be decreased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists