Tramadol

Tramadol is used to relieve moderate to moderately severe pain. Tramadol extended-release tablets and capsules are only used by people who are expected to need medication to relieve pain around-the-clock. Tramadol is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.

Tramadol comes as a tablet, a solution (liquid), an extended-release (long-acting) tablet, and an extended-release (long-acting) capsule to take by mouth. The regular tablet and solution are taken usually with or without food every 4 to 6 hours as needed. The extended-release tablet and extended-release capsule should be taken once a day. Take the extended-release tablet and the extended-release capsule at about the same time of day every day. If you are taking the extended-release capsule, you may take it with or without food. If you are taking the extended-release tablet, you should either always take it with food or always take it without food. Take tramadol exactly as directed. Do not take more medication as a single dose or take more doses per day than prescribed by your doctor. Taking more tramadol than prescribed by your doctor or in a way that is not recommended may cause serious side effects or death.

Your doctor may start you on a low dose of tramadol and gradually increase the amount of medication you take, not more often than every 3 days if you are taking the solution, regular tablets or orally disintegrating tablets or every 5 days if you are taking the extended-release tablets or extended-release capsules.

If you are taking the solution, use an oral syringe or measuring spoon or cup to measure the correct amount of liquid needed for each dose. Do not use a regular household spoon to measure your dose. Ask your doctor or pharmacist if you need help getting or using a measuring device,

Do not stop taking tramadol without talking to your doctor. Your doctor will probably decrease your dose gradually. If you suddenly stop taking tramadol, you may experience withdrawal symptoms such as nervousness; panic; sweating; difficulty falling asleep or staying asleep; runny nose, sneezing, or cough; pain; hair standing on end; chills; nausea; uncontrollable shaking of a part of your body; diarrhea; or rarely, hallucinations (seeing things or hearing voices that do not exist).

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking tramadol,

• tell your doctor and pharmacist if you are allergic to tramadol, other opiate pain medications, any other medications, or any of the ingredients in tramadol products. Ask your pharmacist for a list of the ingredients.

• tell your doctor or pharmacist if you are taking or receiving the following monoamine oxidase (MAO) inhibitors or if you have stopped taking them within the past 2 weeks: isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate). Your doctor will probably tell you not to take tramadol if you are taking one or more of these medications, or have taken them within the past 2 weeks.

• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); bupropion (Aplenzin, Wellbutrin, Zyban); cyclobenzaprine (Amrix); dextromethorphan (found in many cough medications; in Nuedexta); digoxin (Lanoxin); diuretics ('water pills'); lithium (Lithobid); certain medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, in Treximet), and zolmitriptan (Zomig); mirtazapine (Remeron); promethazine; 5-HT₃ receptor antagonists such as alosetron (Lotronex), dolasetron (Anzemet), granisetron (Kytril), ondansetron (Zofran, Zuplenz), or palonosetron (Aloxi); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra), fluvoxamine (Luvox), paroxetine (Paxil, Pexeva), and sertraline (Zoloft); serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Pristiq, Khedezla), duloxetine (Cymbalta), milnacipran (Savella), and venlafaxine (Effexor); trazodone (Oleptro); and tricyclic antidepressants such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor, Zonalon), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil). Many other medications may also interact with tramadol, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• tell your doctor what herbal products you are taking, especially St. John's wort and tryptophan.

• tell your doctor if you have any of the conditions mentioned in the IMPORTANT WARNING section, a blockage or narrowing of your stomach or intestines, or paralytic ileus (condition in which digested food does not move through the intestines). Your doctor may tell you not to take tramadol if you have any of these conditions.

• tell your doctor if you have or have ever had seizures; an infection in your brain or spine; difficulty urinating; thoughts about harming or killing yourself or planning or trying to do so; or kidney or liver disease.

• tell your doctor if you are breastfeeding. You should not breastfeed while taking tramadol. Tramadol can cause shallow breathing, difficulty or noisy breathing, confusion, more than usual sleepiness, trouble breastfeeding, or limpness in breastfed infants.

• you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of taking tramadol.

• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking tramadol.

• you should know that this medication may make you drowsy and may affect your coordination. Do not drive a car or operate machinery until you know how this medication affects you.

• you should know that tramadol may cause dizziness, lightheadedness, and fainting when you get up from a lying position. To avoid this, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

• if you have phenylketonuria (PKU; an inherited condition in which a special diet must be followed to prevent damage to your brain that can cause severe intellectual disability, you should know that the orally disintegrating tablets contain aspartame, a source of phenylalanine.

• you should know that tramadol may cause constipation. Talk to your doctor about changing your diet and using other medications to treat or prevent constipation.

Unless your doctor tells you otherwise, continue your normal diet.

If your doctor has told you to take tramadol regularly, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Tramadol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • sleepiness

  • headache

  • nervousness

  • uncontrollable shaking of a part of the body

  • muscle tightness

  • changes in mood

  • heartburn or indigestion

  • dry mouth

• Some side effects can be serious. If you experience any of these symptoms or those mentioned in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:

  • hives

  • rash

  • blisters

  • hoarseness

  • difficulty swallowing or breathing

  • swelling of the eyes, face, throat, tongue, lips, hands, feet, ankles, or lower legs

  • agitation, hallucinations (seeing things or hearing voices that do not exist), fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea

  • nausea, vomiting, loss of appetite, weakness, or dizziness

  • changes in heartbeat

  • nausea, vomiting, headache, confusion, loss of energy, drowsiness, fatigue, restlessness, irritability, muscle weakness, spasms or cramps

  • hunger, headache, sweating, shaking of a part of your body that you cannot control, irritability, or difficulty concentrating

  • loss of consciousness

  • seizures

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

• Tramadol may cause other side effects. Tell your doctor if you have any unusual problems while you are taking this medication.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

While taking tramadol, you should talk to your doctor about having a rescue medication called naloxone readily available (e.g., home, office). Naloxone is used to reverse the life-threatening effects of an overdose. It works by blocking the effects of opiates to relieve dangerous symptoms caused by high levels of opiates in the blood. Your doctor may also prescribe you naloxone if you are living in a household where there are small children or someone who has abused street or prescription drugs. You should make sure that you and your family members, caregivers, or the people who spend time with you know how to recognize an overdose, how to use naloxone, and what to do until emergency medical help arrives. Your doctor or pharmacist will show you and your family members how to use the medication. Ask your pharmacist for the instructions or visit the manufacturer's website to get the instructions. If symptoms of an overdose occur, a friend or family member should give the first dose of naloxone, call 911 immediately, and stay with you and watch you closely until emergency medical help arrives. Your symptoms may return within a few minutes after you receive naloxone. If your symptoms return, the person should give you another dose of naloxone. Additional doses may be given every 2 to 3 minutes, if symptoms return before medical help arrives.

Symptoms of overdose may include the following:

• decreased size of the pupil (the black circle in the center of the eye)

• difficulty breathing

• slow or shallowing breathing

• extreme drowsiness or sleepiness

• unable to respond or wake up

• slowed heartbeat

• muscle weakness

• cold, clammy skin

Keep all appointments with your doctor and laboratory. Your doctor may order certain lab tests to check your body's response to tramadol.

Before having any laboratory test (especially those that involve methylene blue), tell your doctor and the laboratory personnel that you are taking tramadol.

Do not let anyone else take your medication. Tramadol is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

• Ultracet^® (containing Acetaminophen, Tramadol)

Drug	Interaction
Delavirdine	Delavirdine The metabolism of Tramadol can be decreased when combined with Delavirdine.
Nevirapine	Nevirapine The metabolism of Nevirapine can be decreased when combined with Tramadol.
Dolasetron	Dolasetron The risk or severity of serotonin syndrome can be increased when Dolasetron is combined with Tramadol.
Anagrelide	Anagrelide The risk or severity of Tachycardia can be increased when Tramadol is combined with Anagrelide.
Bisacodyl	Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Tramadol.
Cilostazol	Cilostazol Tramadol may decrease the excretion rate of Cilostazol which could result in a higher serum level.
Clopidogrel	Clopidogrel Tramadol can cause a decrease in the absorption of Clopidogrel resulting in a reduced serum concentration and potentially a decrease in efficacy.
Diphenoxylate	Diphenoxylate The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Diphenoxylate.
Erythromycin and Sulfisoxazole	Erythromycin and Sulfisoxazole The metabolism of Tramadol can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) Tramadol may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate	Fenofibrate Tramadol may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Guanfacine	Guanfacine The risk or severity of CNS depression can be increased when Guanfacine is combined with Tramadol.
Magnesium Hydroxide	Magnesium Hydroxide Tramadol may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Magnesium Oxide	Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Tramadol.
Methylergonovine	Methylergonovine The metabolism of Tramadol can be decreased when combined with Methylergometrine.
Mycophenolate	Mycophenolate Tramadol may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Naratriptan	Naratriptan The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Naratriptan.
Olsalazine	Olsalazine Olsalazine may decrease the excretion rate of Tramadol which could result in a higher serum level.
Paregoric	Paregoric The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Morphine.
Penbutolol	Penbutolol The metabolism of Tramadol can be decreased when combined with Acebutolol.
Pentazocine	Pentazocine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Pentazocine.
Polyethylene glycol-electrolyte solution (PEG-ES)	Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Tramadol.
Potassium	Potassium Tramadol may increase the excretion rate of Potassium cation which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone	Prednisone Tramadol may decrease the excretion rate of Prednisone which could result in a higher serum level.
Psyllium	Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Tramadol.
Ranitidine	Ranitidine The metabolism of Tramadol can be decreased when combined with Ranitidine.
Reserpine	Reserpine The risk or severity of CNS depression can be increased when Reserpine is combined with Tramadol.
Rizatriptan	Rizatriptan The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Rizatriptan.
Sumatriptan	Sumatriptan The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Sumatriptan.
Tacrolimus	Tacrolimus The metabolism of Tacrolimus can be decreased when combined with Tramadol.
Tizanidine	Tizanidine The risk or severity of CNS depression can be increased when Tizanidine is combined with Tramadol.
Triamcinolone	Triamcinolone The metabolism of Tramadol can be increased when combined with Triamcinolone.
Zolmitriptan	Zolmitriptan The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Zolmitriptan.
Ampicillin Injection	Ampicillin Injection Tramadol may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Doxycycline Injection	Doxycycline Injection Tramadol may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Fluconazole Injection	Fluconazole Injection The metabolism of Tramadol can be decreased when combined with Fluconazole.
Foscarnet Injection	Foscarnet Injection Foscarnet may decrease the excretion rate of Tramadol which could result in a higher serum level.
Hydromorphone Injection	Hydromorphone Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Hydromorphone.
Levofloxacin Injection	Levofloxacin Injection Tramadol may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Meperidine Injection	Meperidine Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Meperidine.
Methylprednisolone Injection	Methylprednisolone Injection The metabolism of Methylprednisolone can be increased when combined with Tramadol.
Metoclopramide Injection	Metoclopramide Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Metoclopramide.
Metronidazole Injection	Metronidazole Injection The metabolism of Tramadol can be decreased when combined with Metronidazole.
Morphine Injection	Morphine Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Morphine.
Pamidronate Injection	Pamidronate Injection Pamidronic acid may decrease the excretion rate of Tramadol which could result in a higher serum level.
Vancomycin Injection	Vancomycin Injection Tramadol may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection	Zidovudine Injection The metabolism of Tramadol can be increased when combined with Zidovudine.
Altretamine	Altretamine The risk or severity of serotonin syndrome and seizure can be increased when Amphetamine is combined with Tramadol.
Cefuroxime	Cefuroxime Cefuroxime may decrease the excretion rate of Tramadol which could result in a higher serum level.
Cyclosporine	Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Tramadol.
Ondansetron	Ondansetron The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Ondansetron.
Granisetron	Granisetron The risk or severity of serotonin syndrome can be increased when Granisetron is combined with Tramadol.
Torsemide	Torsemide The therapeutic efficacy of Torasemide can be decreased when used in combination with Tramadol.
Olanzapine	Olanzapine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Olanzapine.
Alosetron	Alosetron The risk or severity of CNS depression can be increased when Alosetron is combined with Tramadol.
Entacapone	Entacapone The metabolism of Tramadol can be decreased when combined with Entacapone.
Hydroxychloroquine	Hydroxychloroquine The metabolism of Tramadol can be decreased when combined with Hydroxychloroquine.
Meloxicam	Meloxicam Meloxicam may decrease the excretion rate of Tramadol which could result in a higher serum level.
Orlistat	Orlistat The metabolism of Tramadol can be increased when combined with Orlistat.
Oxcarbazepine	Oxcarbazepine The metabolism of Oxcarbazepine can be decreased when combined with Tramadol.
Pantoprazole	Pantoprazole Tramadol may decrease the excretion rate of Pantoprazole which could result in a higher serum level.
Temozolomide	Temozolomide Tramadol may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon	Zaleplon The risk or severity of CNS depression can be increased when Zaleplon is combined with Tramadol.
Anakinra	Anakinra The metabolism of Tramadol can be increased when combined with Anakinra.
Desloratadine	Desloratadine The risk or severity of CNS depression can be increased when Tramadol is combined with Desloratadine.
Linezolid	Linezolid The risk or severity of serotonin syndrome and seizure can be increased when Linezolid is combined with Tramadol.
Rivastigmine	Rivastigmine The therapeutic efficacy of Tramadol can be decreased when used in combination with Rivastigmine.
Trimipramine	Trimipramine The risk or severity of serotonin syndrome can be increased when Trimipramine is combined with Tramadol.
Etanercept Injection	Etanercept Injection The metabolism of Tramadol can be increased when combined with Etanercept.
Glycopyrrolate	Glycopyrrolate The risk or severity of adverse effects can be increased when Tramadol is combined with Glycopyrronium.
Modafinil	Modafinil The metabolism of Tramadol can be increased when combined with Armodafinil.
Perindopril	Perindopril Tramadol may decrease the excretion rate of Perindopril which could result in a higher serum level.
Tenofovir	Tenofovir Tenofovir may decrease the excretion rate of Tramadol which could result in a higher serum level.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Tramadol which could result in a higher serum level.
Epinephrine Injection	Epinephrine Injection The metabolism of Epinephrine can be decreased when combined with Tramadol.
Eplerenone	Eplerenone Eplerenone may increase the excretion rate of Tramadol which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram	Escitalopram The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Escitalopram.
Zonisamide	Zonisamide The risk or severity of CNS depression can be increased when Zonisamide is combined with Tramadol.
Adalimumab Injection	Adalimumab Injection The metabolism of Tramadol can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Aripiprazole.
Atomoxetine	Atomoxetine The risk or severity of CNS depression can be increased when Tramadol is combined with Atomoxetine.
Dexmethylphenidate	Dexmethylphenidate The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Dexmethylphenidate.
Atazanavir	Atazanavir The metabolism of Tramadol can be decreased when combined with Atazanavir.
Almotriptan	Almotriptan The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Almotriptan.
Eletriptan	Eletriptan The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Eletriptan.
Mefloquine	Mefloquine The metabolism of Tramadol can be decreased when combined with Mefloquine.
Polyethylene Glycol 3350	Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Tramadol.
Aprepitant	Aprepitant The metabolism of Tramadol can be decreased when combined with Aprepitant.
Emtricitabine	Emtricitabine Tramadol may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine	Memantine The risk or severity of adverse effects can be increased when Tramadol is combined with Memantine.
Tegaserod	Tegaserod The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Tegaserod.
Tadalafil	Tadalafil Tramadol may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Frovatriptan	Frovatriptan The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Frovatriptan.
Progesterone	Progesterone The metabolism of Tramadol can be increased when combined with Progesterone.
Apomorphine Injection	Apomorphine Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Apomorphine.
Infliximab Injection	Infliximab Injection The metabolism of Tramadol can be increased when combined with Infliximab.
Protriptyline	Protriptyline The risk or severity of serotonin syndrome can be increased when Protriptyline is combined with Tramadol.
Rifaximin	Rifaximin The metabolism of Tramadol can be increased when combined with Rifaximin.
Duloxetine	Duloxetine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Duloxetine.
Tinidazole	Tinidazole Tramadol may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Trospium	Trospium The metabolism of Trospium can be decreased when combined with Tramadol.
Bosentan	Bosentan The metabolism of Tramadol can be increased when combined with Bosentan.
Cefditoren	Cefditoren Tramadol may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cinacalcet	Cinacalcet The metabolism of Tramadol can be decreased when combined with Cinacalcet.
Cyanocobalamin Injection	Cyanocobalamin Injection Tramadol may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
Erlotinib	Erlotinib The metabolism of Tramadol can be decreased when combined with Erlotinib.
Eszopiclone	Eszopiclone The risk or severity of CNS depression can be increased when Tramadol is combined with Eszopiclone.
Ganciclovir	Ganciclovir Tramadol may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Ribavirin	Ribavirin Tramadol may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Solifenacin	Solifenacin The risk or severity of adverse effects can be increased when Tramadol is combined with Solifenacin.
Valganciclovir	Valganciclovir Tramadol may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole	Voriconazole The metabolism of Tramadol can be decreased when combined with Voriconazole.
Adefovir	Adefovir Adefovir may decrease the excretion rate of Tramadol which could result in a higher serum level.
Dextroamphetamine	Dextroamphetamine The risk or severity of serotonin syndrome and seizure can be increased when Amphetamine is combined with Tramadol.
Peginterferon Alfa-2b (PEG-Intron)	Peginterferon Alfa-2b (PEG-Intron) The metabolism of Tramadol can be decreased when combined with Peginterferon alfa-2b.
Pramlintide Injection	Pramlintide Injection The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Tramadol.
Sodium Oxybate	Sodium Oxybate The risk or severity of CNS depression can be increased when Sodium oxybate is combined with Tramadol.
Isocarboxazid	Isocarboxazid The risk or severity of serotonin syndrome and seizure can be increased when Isocarboxazid is combined with Tramadol.
Ramelteon	Ramelteon The risk or severity of CNS depression can be increased when Ramelteon is combined with Tramadol.
Darifenacin	Darifenacin The metabolism of Darifenacin can be decreased when combined with Tramadol.
Fentanyl	Fentanyl The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Fentanyl.
Pregabalin	Pregabalin The therapeutic efficacy of Tramadol can be increased when used in combination with Pregabalin.
Deferasirox	Deferasirox The metabolism of Tramadol can be increased when combined with Deferasirox.
Phenylephrine	Phenylephrine The risk or severity of Tachycardia can be increased when Tramadol is combined with Phenylephrine.
Tipranavir	Tipranavir The metabolism of Tipranavir can be decreased when combined with Tramadol.
Felbamate	Felbamate The metabolism of Tramadol can be increased when combined with Felbamate.
Ranolazine	Ranolazine The metabolism of Tramadol can be decreased when combined with Ranolazine.
Abatacept Injection	Abatacept Injection The metabolism of Tramadol can be increased when combined with Abatacept.
Rasagiline	Rasagiline The risk or severity of serotonin syndrome and seizure can be increased when Rasagiline is combined with Tramadol.
Imatinib	Imatinib The metabolism of Tramadol can be decreased when combined with Imatinib.
Sitagliptin	Sitagliptin Tramadol may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Varenicline	Varenicline Tramadol may decrease the excretion rate of Varenicline which could result in a higher serum level.
Gefitinib	Gefitinib The metabolism of Tramadol can be decreased when combined with Gefitinib.
Albuterol	Albuterol Tramadol may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone	Paliperidone The risk or severity of serotonin syndrome can be increased when Paliperidone is combined with Tramadol.
Bortezomib	Bortezomib The metabolism of Tramadol can be decreased when combined with Bortezomib.
Clofarabine Injection	Clofarabine Injection Tramadol may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Lubiprostone	Lubiprostone Tramadol may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Posaconazole	Posaconazole The metabolism of Tramadol can be decreased when combined with Posaconazole.
Primaquine	Primaquine The metabolism of Tramadol can be decreased when combined with Primaquine.
Darunavir	Darunavir The metabolism of Darunavir can be decreased when combined with Tramadol.
Pemetrexed Injection	Pemetrexed Injection Tramadol may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dimenhydrinate	Dimenhydrinate The risk or severity of CNS depression can be increased when Dimenhydrinate is combined with Tramadol.
Lisdexamfetamine	Lisdexamfetamine The risk or severity of serotonin syndrome can be increased when Lisdexamfetamine is combined with Tramadol.
Nabilone	Nabilone The risk or severity of CNS depression can be increased when Nabilone is combined with Tramadol.
Sorafenib	Sorafenib The metabolism of Tramadol can be decreased when combined with Sorafenib.
Sunitinib	Sunitinib The metabolism of Tramadol can be decreased when combined with Sunitinib.
Dronabinol	Dronabinol The risk or severity of CNS depression can be increased when Dronabinol is combined with Tramadol.
Lapatinib	Lapatinib The metabolism of Tramadol can be decreased when combined with Lapatinib.
Levocetirizine	Levocetirizine The risk or severity of CNS depression can be increased when Levocetirizine is combined with Tramadol.
Pegaptanib Injection	Pegaptanib Injection Tramadol may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib	Dasatinib The metabolism of Dasatinib can be decreased when combined with Tramadol.
Mexiletine	Mexiletine The metabolism of Mexiletine can be decreased when combined with Tramadol.
Armodafinil	Armodafinil The metabolism of Tramadol can be increased when combined with Armodafinil.
Azacitidine Injection	Azacitidine Injection Tramadol may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Paclitaxel (with polyoxyethylated castor oil) Injection	Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Tramadol.
Temsirolimus	Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Tramadol.
Lenalidomide	Lenalidomide Tramadol may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Nilotinib	Nilotinib The metabolism of Tramadol can be decreased when combined with Nilotinib.
Bexarotene	Bexarotene The metabolism of Tramadol can be increased when combined with Bexarotene.
Budesonide	Budesonide The metabolism of Budesonide can be increased when combined with Tramadol.
Chloramphenicol Injection	Chloramphenicol Injection The metabolism of Tramadol can be decreased when combined with Chloramphenicol.
Desmopressin	Desmopressin The risk or severity of hyponatremia can be increased when Tramadol is combined with Desmopressin.
Betaine	Betaine The therapeutic efficacy of Tramadol can be decreased when used in combination with Glycine betaine.
OnabotulinumtoxinA Injection	OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Tramadol is combined with Botulinum toxin type A.
RimabotulinumtoxinB Injection	RimabotulinumtoxinB Injection The risk or severity of CNS depression can be increased when Tramadol is combined with Botulinum Toxin Type B.
Doripenem Injection	Doripenem Injection Tramadol may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine	Etravirine The metabolism of Tramadol can be increased when combined with Etravirine.
Arsenic Trioxide Injection	Arsenic Trioxide Injection Tramadol may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Mitoxantrone Injection	Mitoxantrone Injection The metabolism of Tramadol can be decreased when combined with Mitoxantrone.
Desvenlafaxine	Desvenlafaxine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Desvenlafaxine.
Cevimeline	Cevimeline Cevimeline may decrease the excretion rate of Tramadol which could result in a higher serum level.
Nebivolol	Nebivolol The metabolism of Nebivolol can be decreased when combined with Tramadol.
Tretinoin	Tretinoin The metabolism of Tretinoin can be decreased when combined with Tramadol.
Pilocarpine	Pilocarpine The metabolism of Tramadol can be decreased when combined with Pilocarpine.
Flecainide	Flecainide The metabolism of Flecainide can be decreased when combined with Tramadol.
Certolizumab Injection	Certolizumab Injection The metabolism of Tramadol can be increased when combined with Certolizumab pegol.
Irinotecan Injection	Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Tramadol.
Daptomycin Injection	Daptomycin Injection Daptomycin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Mitotane	Mitotane The metabolism of Tramadol can be increased when combined with Mitotane.
Alvimopan	Alvimopan The risk or severity of adverse effects can be increased when Tramadol is combined with Alvimopan.
Methylnaltrexone Injection	Methylnaltrexone Injection The therapeutic efficacy of Tramadol can be decreased when used in combination with Methylnaltrexone.
Rufinamide	Rufinamide The metabolism of Tramadol can be increased when combined with Rufinamide.
Midazolam	Midazolam The metabolism of Midazolam can be decreased when combined with Tramadol.
Naltrexone Injection	Naltrexone Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Naltrexone.
Dexrazoxane Injection	Dexrazoxane Injection Tramadol may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
Eltrombopag	Eltrombopag The metabolism of Tramadol can be decreased when combined with Eltrombopag.
Milnacipran	Milnacipran The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Milnacipran.
Plerixafor Injection	Plerixafor Injection Tramadol may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Sodium Phosphate	Sodium Phosphate The therapeutic efficacy of Sodium phosphate, monobasic can be decreased when used in combination with Tramadol.
Fesoterodine	Fesoterodine The risk or severity of adverse effects can be increased when Tramadol is combined with Fesoterodine.
Betaxolol	Betaxolol The metabolism of Betaxolol can be decreased when combined with Tramadol.
Iloperidone	Iloperidone The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Iloperidone.
Prasugrel	Prasugrel The metabolism of Prasugrel can be decreased when combined with Tramadol.
Lacosamide	Lacosamide The risk or severity of CNS depression can be increased when Lacosamide is combined with Tramadol.
Everolimus	Everolimus The metabolism of Everolimus can be decreased when combined with Tramadol.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Tramadol which could result in a lower serum level and potentially a reduction in efficacy.
Dronedarone	Dronedarone The metabolism of Dronedarone can be decreased when combined with Tramadol.
AbobotulinumtoxinA Injection	AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Tramadol is combined with Botulinum toxin type A.
Pralatrexate Injection	Pralatrexate Injection Tramadol may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection	Palonosetron Injection The risk or severity of serotonin syndrome can be increased when Palonosetron is combined with Tramadol.
Saxagliptin	Saxagliptin Tramadol may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection	Telavancin Injection Tramadol may decrease the excretion rate of Telavancin which could result in a higher serum level.
Romidepsin Injection	Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Tramadol.
Tapentadol	Tapentadol The risk or severity of serotonin syndrome can be increased when Tapentadol is combined with Tramadol.
Topotecan	Topotecan The metabolism of Topotecan can be decreased when combined with Tramadol.
Golimumab Injection	Golimumab Injection The metabolism of Tramadol can be increased when combined with Golimumab.
Pazopanib	Pazopanib The metabolism of Tramadol can be decreased when combined with Pazopanib.
Asenapine	Asenapine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Asenapine.
Vigabatrin	Vigabatrin The risk or severity of CNS depression can be increased when Vigabatrin is combined with Tramadol.
Oxymorphone	Oxymorphone The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Oxymorphone.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Tramadol can be increased when combined with Tocilizumab.
Dalfampridine	Dalfampridine The risk or severity of seizure can be increased when Tramadol is combined with Dalfampridine.
IncobotulinumtoxinA Injection	IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Tramadol is combined with Botulinum toxin type A.
Ceftaroline Injection	Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Tramadol which could result in a higher serum level.
Lurasidone	Lurasidone The risk or severity of serotonin syndrome can be increased when Lurasidone is combined with Tramadol.
Vilazodone	Vilazodone The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Vilazodone.
Ipilimumab Injection	Ipilimumab Injection Tramadol may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection	Denileukin Diftitox Injection The metabolism of Tramadol can be decreased when combined with Aldesleukin.
Terbutaline Injection	Terbutaline Injection The therapeutic efficacy of Tramadol can be decreased when used in combination with Terbutaline.
Roflumilast	Roflumilast Tramadol may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Linagliptin	Linagliptin The metabolism of Tramadol can be decreased when combined with Linagliptin.
Rilpivirine	Rilpivirine The metabolism of Rilpivirine can be decreased when combined with Tramadol.
Telaprevir	Telaprevir The metabolism of Tramadol can be decreased when combined with Glecaprevir.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Cyclophosphamide can be increased when combined with Tramadol.
Abiraterone	Abiraterone The metabolism of Tramadol can be decreased when combined with Abiraterone.
Rivaroxaban	Rivaroxaban Tramadol may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor	Ticagrelor Tramadol can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy.
Brentuximab Vedotin Injection	Brentuximab Vedotin Injection The metabolism of Tramadol can be decreased when combined with Brentuximab vedotin.
Ruxolitinib	Ruxolitinib Tramadol may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Clobazam	Clobazam The metabolism of Clobazam can be decreased when combined with Tramadol.
Vemurafenib	Vemurafenib The metabolism of Tramadol can be decreased when combined with Vemurafenib.
Ivacaftor	Ivacaftor The metabolism of Tramadol can be decreased when combined with Ivacaftor.
Deferiprone	Deferiprone Tramadol may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Crizotinib	Crizotinib The metabolism of Tramadol can be decreased when combined with Crizotinib.
Cabergoline	Cabergoline The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Cabergoline.
Naloxone Injection	Naloxone Injection The metabolism of Naloxone can be decreased when combined with Tramadol.
Fondaparinux Injection	Fondaparinux Injection Tramadol may decrease the excretion rate of Fondaparinux which could result in a higher serum level.
Ezogabine	Ezogabine The risk or severity of CNS depression can be increased when Tiagabine is combined with Tramadol.
Enzalutamide	Enzalutamide The metabolism of Tramadol can be increased when combined with Enzalutamide.
Mirabegron	Mirabegron The risk or severity of urinary retention can be increased when Tramadol is combined with Mirabegron.
Regorafenib	Regorafenib The metabolism of Tramadol can be decreased when combined with Regorafenib.
Bosutinib	Bosutinib The metabolism of Tramadol can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection	Corticotropin, Repository Injection The metabolism of Tramadol can be increased when combined with Corticotropin.
Linaclotide	Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Tramadol.
Teduglutide Injection	Teduglutide Injection Tramadol may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Alogliptin	Alogliptin Tramadol may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Ponatinib	Ponatinib The metabolism of Ponatinib can be decreased when combined with Tramadol.
Pomalidomide	Pomalidomide The risk or severity of CNS depression can be increased when Tramadol is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Tramadol.
Canagliflozin	Canagliflozin Tramadol may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide	Methazolamide The therapeutic efficacy of Methazolamide can be decreased when used in combination with Tramadol.
Dabrafenib	Dabrafenib The metabolism of Dabrafenib can be increased when combined with Tramadol.
Ospemifene	Ospemifene The metabolism of Ospemifene can be decreased when combined with Tramadol.
Trametinib	Trametinib The metabolism of Trametinib can be increased when combined with Tramadol.
Levomilnacipran	Levomilnacipran The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Levomilnacipran.
Ertapenem Injection	Ertapenem Injection Tramadol may decrease the excretion rate of Ertapenem which could result in a higher serum level.
Vortioxetine	Vortioxetine The risk or severity of serotonin syndrome can be increased when Vortioxetine is combined with Tramadol.
Perampanel	Perampanel The metabolism of Tramadol can be increased when combined with Perampanel.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Tramadol.
Lomitapide	Lomitapide The metabolism of Lomitapide can be decreased when combined with Tramadol.
Ketorolac Injection	Ketorolac Injection Ketorolac may decrease the excretion rate of Tramadol which could result in a higher serum level.
Simeprevir	Simeprevir The metabolism of Tramadol can be decreased when combined with Simeprevir.
Sofosbuvir	Sofosbuvir Tramadol may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin	Dapagliflozin Tramadol may increase the excretion rate of Dapagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast	Apremilast The metabolism of Tramadol can be increased when combined with Apremilast.
Droxidopa	Droxidopa Tramadol may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib	Ceritinib The metabolism of Ceritinib can be decreased when combined with Tramadol.
Siltuximab Injection	Siltuximab Injection The metabolism of Tramadol can be decreased when combined with Siltuximab.
Eslicarbazepine	Eslicarbazepine The metabolism of Tramadol can be increased when combined with Eslicarbazepine.
Idelalisib	Idelalisib The metabolism of Tramadol can be decreased when combined with Idelalisib.
Testosterone Injection	Testosterone Injection The metabolism of Tramadol can be increased when combined with Testosterone.
Oritavancin Injection	Oritavancin Injection The metabolism of Tramadol can be increased when combined with Oritavancin.
Hydrocodone	Hydrocodone The risk or severity of serotonin syndrome can be increased when Hydrocodone is combined with Tramadol.
Suvorexant	Suvorexant Tramadol may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Edoxaban	Edoxaban Tramadol may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Olaparib	Olaparib The metabolism of Olaparib can be decreased when combined with Tramadol.
Methamphetamine	Methamphetamine The risk or severity of serotonin syndrome can be increased when Metamfetamine is combined with Tramadol.
Tasimelteon	Tasimelteon The risk or severity of CNS depression can be increased when Tasimelteon is combined with Tramadol.
Lanreotide Injection	Lanreotide Injection The metabolism of Tramadol can be decreased when combined with Lanreotide.
Secukinumab Injection	Secukinumab Injection The metabolism of Tramadol can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Risperidone.
Palbociclib	Palbociclib The metabolism of Tramadol can be decreased when combined with Palbociclib.
Lenvatinib	Lenvatinib The metabolism of Tramadol can be decreased when combined with Lenvatinib.
Naloxegol	Naloxegol The metabolism of Tramadol can be decreased when combined with Naloxegol.
Panobinostat	Panobinostat The metabolism of Tramadol can be decreased when combined with Panobinostat.
Haloperidol Injection	Haloperidol Injection The metabolism of Haloperidol can be decreased when combined with Tramadol.
Amiloride	Amiloride The therapeutic efficacy of Amiloride can be decreased when used in combination with Tramadol.
Isavuconazonium Injection	Isavuconazonium Injection The metabolism of Tramadol can be decreased when combined with Isavuconazonium.
Macitentan	Macitentan Tramadol may decrease the excretion rate of Macitentan which could result in a higher serum level.
Flibanserin	Flibanserin The risk or severity of serotonin syndrome can be increased when Flibanserin is combined with Tramadol.
Rolapitant	Rolapitant The metabolism of Tramadol can be decreased when combined with Rolapitant.
Prednisolone	Prednisolone The metabolism of Prednisolone can be increased when combined with Tramadol.
Brexpiprazole	Brexpiprazole The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Brexpiprazole.
Ziprasidone Injection	Ziprasidone Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Ziprasidone.
Cariprazine	Cariprazine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Cariprazine.
Penicillin G Procaine Injection	Penicillin G Procaine Injection Tramadol may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline	Eluxadoline The risk or severity of constipation can be increased when Tramadol is combined with Eluxadoline.
Trabectedin Injection	Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Tramadol.
Osimertinib	Osimertinib The metabolism of Osimertinib can be decreased when combined with Tramadol.
Ixazomib	Ixazomib Tramadol may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Rifapentine	Rifapentine The metabolism of Tramadol can be increased when combined with Rifapentine.
Lesinurad	Lesinurad Tramadol may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection The metabolism of Tramadol can be decreased when combined with Amphotericin B.
Dexamethasone Injection	Dexamethasone Injection The metabolism of Tramadol can be decreased when combined with Dexamethasone.
Brivaracetam Injection	Brivaracetam Injection The risk or severity of CNS depression can be increased when Brivaracetam is combined with Tramadol.
Venetoclax	Venetoclax The metabolism of Tramadol can be decreased when combined with Venetoclax.
Cobicistat	Cobicistat The metabolism of Tramadol can be decreased when combined with Cobicistat.
Midodrine	Midodrine The risk or severity of Tachycardia can be increased when Tramadol is combined with Midodrine.
Pimavanserin	Pimavanserin The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Pimavanserin.
Diphenhydramine Injection	Diphenhydramine Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Diphenhydramine.
Furosemide Injection	Furosemide Injection Tramadol may increase the excretion rate of Furosemide which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib	Rucaparib The metabolism of Tramadol can be decreased when combined with Rucaparib.
Lixisenatide Injection	Lixisenatide Injection Tramadol may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ribociclib	Ribociclib The metabolism of Tramadol can be decreased when combined with Ribociclib.
Brigatinib	Brigatinib The metabolism of Tramadol can be increased when combined with Brigatinib.
Doxepin (Insomnia)	Doxepin (Insomnia) The risk or severity of serotonin syndrome can be increased when Doxepin is combined with Tramadol.
Plecanatide	Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Tramadol.
Deutetrabenazine	Deutetrabenazine Tramadol may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine	Valbenazine Tramadol may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Safinamide	Safinamide The risk or severity of serotonin syndrome and seizure can be increased when Safinamide is combined with Tramadol.
Naldemedine	Naldemedine The therapeutic efficacy of Tramadol can be decreased when used in combination with Naldemedine.
Sarilumab Injection	Sarilumab Injection The metabolism of Tramadol can be decreased when combined with Sarilumab.
Midostaurin	Midostaurin The metabolism of Tramadol can be decreased when combined with Midostaurin.
Enasidenib	Enasidenib The metabolism of Tramadol can be decreased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection	Aprepitant/Fosaprepitant Injection The metabolism of Tramadol can be decreased when combined with Fosaprepitant.
Benznidazole	Benznidazole Tramadol may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin	Delafloxacin The metabolism of Delafloxacin can be increased when combined with Tramadol.
Acalabrutinib	Acalabrutinib The metabolism of Tramadol can be decreased when combined with Acalabrutinib.
Letermovir	Letermovir The metabolism of Tramadol can be decreased when combined with Letermovir.
Tetrabenazine	Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Tramadol.
Ertugliflozin	Ertugliflozin The metabolism of Tramadol can be decreased when combined with Ertugliflozin.
Buprenorphine Injection	Buprenorphine Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Buprenorphine.
Apalutamide	Apalutamide The metabolism of Apalutamide can be increased when combined with Tramadol.
Fostamatinib	Fostamatinib The metabolism of Tramadol can be decreased when combined with Fostamatinib.
Baricitinib	Baricitinib Tramadol may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine	Lofexidine The risk or severity of serotonin syndrome can be increased when Lofexidine is combined with Tramadol.
Plazomicin Injection	Plazomicin Injection Tramadol may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat	Eliglustat The metabolism of Tramadol can be decreased when combined with Eliglustat.
Encorafenib	Encorafenib The metabolism of Encorafenib can be decreased when combined with Tramadol.
Ivosidenib	Ivosidenib The metabolism of Tramadol can be increased when combined with Ivosidenib.
Elagolix	Elagolix The metabolism of Elagolix can be decreased when combined with Tramadol.
Tafenoquine	Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Tramadol.
Cannabidiol	Cannabidiol The risk or severity of serotonin syndrome can be increased when Cannabidiol is combined with Tramadol.
Dacomitinib	Dacomitinib The metabolism of Tramadol can be decreased when combined with Dacomitinib.
Stiripentol	Stiripentol The metabolism of Tramadol can be decreased when combined with Stiripentol.
Gilteritinib	Gilteritinib The therapeutic efficacy of Tramadol can be decreased when used in combination with Gilteritinib.
Lorlatinib	Lorlatinib The metabolism of Tramadol can be increased when combined with Lorlatinib.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Tramadol.
Rifamycin	Rifamycin The metabolism of Tramadol can be decreased when combined with Rifamycin.
Prucalopride	Prucalopride Tramadol may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Magnesium Citrate	Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Tramadol.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Tramadol can be increased when combined with Emapalumab.
Acyclovir Ophthalmic	Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Tramadol which could result in a higher serum level.
Alpelisib	Alpelisib The metabolism of Tramadol can be decreased when combined with Alpelisib.
Brexanolone Injection	Brexanolone Injection The risk or severity of CNS depression can be increased when Brexanolone is combined with Tramadol.
Solriamfetol	Solriamfetol The risk or severity of Tachycardia can be increased when Solriamfetol is combined with Tramadol.
Triclabendazole	Triclabendazole The metabolism of Tramadol can be decreased when combined with Triclabendazole.
Pexidartinib	Pexidartinib The metabolism of Tramadol can be decreased when combined with Pexidartinib.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Tramadol.
Pitolisant	Pitolisant The serum concentration of Tramadol can be decreased when it is combined with Pitolisant.
Fedratinib	Fedratinib The metabolism of Tramadol can be decreased when combined with Fedratinib.
Phenytoin Injection	Phenytoin Injection The metabolism of Phenytoin can be increased when combined with Tramadol.
Fosphenytoin Injection	Fosphenytoin Injection The metabolism of Tramadol can be increased when combined with Fosphenytoin.
Zanubrutinib	Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Tramadol.
Voxelotor	Voxelotor The metabolism of Voxelotor can be decreased when combined with Tramadol.
Lumateperone	Lumateperone The risk or severity of CNS depression can be increased when Lumateperone is combined with Tramadol.
Lasmiditan	Lasmiditan The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Lasmiditan.
Cenobamate	Cenobamate The serum concentration of Cenobamate can be decreased when it is combined with Tramadol.
Tucatinib	Tucatinib The metabolism of Tucatinib can be decreased when combined with Tramadol.
Remdesivir Injection	Remdesivir Injection The metabolism of Tramadol can be decreased when combined with Remdesivir.
Lemborexant	Lemborexant The serum concentration of Tramadol can be decreased when it is combined with Lemborexant.
Fenfluramine	Fenfluramine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Fenfluramine.
Octreotide	Octreotide The metabolism of Tramadol can be decreased when combined with Octreotide.
Pralsetinib	Pralsetinib The metabolism of Tramadol can be decreased when combined with Pralsetinib.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Tramadol can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives The therapeutic efficacy of Drospirenone can be decreased when used in combination with Tramadol.
Viloxazine	Viloxazine The risk or severity of CNS depression can be increased when Tramadol is combined with Viloxazine.
Vitamin E (Alpha-Tocopherol)	Vitamin E (Alpha-Tocopherol) The metabolism of Tramadol can be increased when combined with Vitamin E.
Tobramycin Injection	Tobramycin Injection Tobramycin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Theophylline	Theophylline The metabolism of Theophylline can be decreased when combined with Tramadol.
Fenoprofen	Fenoprofen Fenoprofen may decrease the excretion rate of Tramadol which could result in a higher serum level.
Indomethacin	Indomethacin Indomethacin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Mefenamic Acid	Mefenamic Acid Mefenamic acid may decrease the excretion rate of Tramadol which could result in a higher serum level.
Naproxen	Naproxen Naproxen may decrease the excretion rate of Tramadol which could result in a higher serum level.
Tolmetin	Tolmetin Tolmetin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Sulindac	Sulindac Sulindac may decrease the excretion rate of Tramadol which could result in a higher serum level.
Trazodone	Trazodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Tramadol.
Isotretinoin	Isotretinoin Tramadol may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate	Sucralfate Tramadol may decrease the excretion rate of Sucralfate which could result in a higher serum level.
Hydroxyurea	Hydroxyurea The metabolism of Tramadol can be decreased when combined with Hydroxyurea.
Floxuridine	Floxuridine Tramadol may decrease the excretion rate of Floxuridine which could result in a higher serum level.
Phenobarbital	Phenobarbital The metabolism of Phenobarbital can be increased when combined with Tramadol.
Metaxalone	Metaxalone The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Metaxalone.
Methotrexate Injection	Methotrexate Injection Methotrexate may decrease the excretion rate of Tramadol which could result in a higher serum level.
Levorphanol	Levorphanol The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Levorphanol.
Primidone	Primidone The metabolism of Tramadol can be increased when combined with Primidone.
Methsuximide	Methsuximide The risk or severity of CNS depression can be increased when Methsuximide is combined with Tramadol.
Diethylpropion	Diethylpropion The risk or severity of serotonin syndrome can be increased when Diethylpropion is combined with Tramadol.
Chlorpromazine	Chlorpromazine The risk or severity of serotonin syndrome can be increased when Chlorpromazine is combined with Tramadol.
Diazepam	Diazepam The metabolism of Diazepam can be decreased when combined with Tramadol.
Oxazepam	Oxazepam The risk or severity of CNS depression can be increased when Tramadol is combined with Oxazepam.
Flurazepam	Flurazepam The risk or severity of CNS depression can be increased when Tramadol is combined with Flurazepam.
Clorazepate	Clorazepate The risk or severity of CNS depression can be increased when Tramadol is combined with Clorazepic acid.
Lorazepam	Lorazepam The risk or severity of CNS depression can be increased when Tramadol is combined with Lorazepam.
Carmustine	Carmustine Tramadol may decrease the excretion rate of Carmustine which could result in a higher serum level.
Amantadine	Amantadine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Amantadine.
Codeine	Codeine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Codeine.
Meprobamate	Meprobamate The risk or severity of CNS depression can be increased when Meprobamate is combined with Tramadol.
Chlordiazepoxide	Chlordiazepoxide The risk or severity of CNS depression can be increased when Tramadol is combined with Chlordiazepoxide.
Bromocriptine	Bromocriptine The metabolism of Bromocriptine can be decreased when combined with Tramadol.
Metaproterenol	Metaproterenol The risk or severity of Tachycardia can be increased when Tramadol is combined with Orciprenaline.
Tranylcypromine	Tranylcypromine The risk or severity of serotonin syndrome and seizure can be increased when Tranylcypromine is combined with Tramadol.
Phenelzine	Phenelzine The risk or severity of serotonin syndrome and seizure can be increased when Phenelzine is combined with Tramadol.
Procarbazine	Procarbazine The risk or severity of serotonin syndrome and seizure can be increased when Procarbazine is combined with Tramadol.
Ergoloid Mesylates	Ergoloid Mesylates The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Ergoloid mesylate.
Tetracycline	Tetracycline The metabolism of Tetracycline can be decreased when combined with Tramadol.
Minocycline	Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Tramadol.
Prochlorperazine	Prochlorperazine The risk or severity of CNS depression can be increased when Prochlorperazine is combined with Tramadol.
Thioridazine	Thioridazine The risk or severity of serotonin syndrome can be increased when Thioridazine is combined with Tramadol.
Trifluoperazine	Trifluoperazine The risk or severity of CNS depression can be increased when Trifluoperazine is combined with Tramadol.
Bleomycin	Bleomycin Tramadol may decrease the excretion rate of Bleomycin which could result in a higher serum level.
Sulfadiazine	Sulfadiazine Tramadol may decrease the excretion rate of Sulfadiazine which could result in a higher serum level.
Oxycodone	Oxycodone The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Oxycodone.
Methadone	Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Tramadol.
Oxybutynin	Oxybutynin The metabolism of Tramadol can be decreased when combined with Oxybutynin.
Benztropine	Benztropine The risk or severity of adverse effects can be increased when Tramadol is combined with Benzatropine.
Maprotiline	Maprotiline The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Maprotiline.
Ibuprofen	Ibuprofen Ibuprofen may decrease the excretion rate of Tramadol which could result in a higher serum level.
Trihexyphenidyl	Trihexyphenidyl The risk or severity of adverse effects can be increased when Tramadol is combined with Trihexyphenidyl.
Orphenadrine	Orphenadrine The metabolism of Orphenadrine can be decreased when combined with Tramadol.
Perphenazine	Perphenazine The metabolism of Tramadol can be decreased when combined with Perphenazine.
Azathioprine	Azathioprine Tramadol may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Fluphenazine	Fluphenazine The metabolism of Tramadol can be decreased when combined with Fluphenazine.
Phentermine	Phentermine The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Tramadol.
Methylphenidate	Methylphenidate Tramadol may decrease the excretion rate of Methylphenidate which could result in a higher serum level.
Amoxapine	Amoxapine The risk or severity of serotonin syndrome can be increased when Amoxapine is combined with Tramadol.
Sulfasalazine	Sulfasalazine Sulfasalazine may decrease the excretion rate of Tramadol which could result in a higher serum level.
Hydrocortisone	Hydrocortisone The metabolism of Hydrocortisone can be increased when combined with Tramadol.
Doxorubicin	Doxorubicin The metabolism of Tramadol can be decreased when combined with Doxorubicin.
Mechlorethamine	Mechlorethamine The therapeutic efficacy of Tramadol can be decreased when used in combination with Mechlorethamine.
Pyridostigmine	Pyridostigmine The therapeutic efficacy of Tramadol can be decreased when used in combination with Pyridostigmine.
Phenazopyridine	Phenazopyridine Phenazopyridine may decrease the excretion rate of Tramadol which could result in a higher serum level.
Carbamazepine	Carbamazepine The therapeutic efficacy of Carbamazepine can be decreased when used in combination with Tramadol.
Molindone	Molindone The risk or severity of CNS depression can be increased when Molindone is combined with Tramadol.
Methyldopa	Methyldopa Tramadol may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Clonidine	Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Tramadol.
Hydralazine	Hydralazine The metabolism of Hydralazine can be decreased when combined with Tramadol.
Gentamicin Injection	Gentamicin Injection Gentamicin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Warfarin	Warfarin The therapeutic efficacy of Warfarin can be increased when used in combination with Tramadol.
Clonazepam	Clonazepam The risk or severity of CNS depression can be increased when Tramadol is combined with Clonazepam.
Loperamide	Loperamide The metabolism of Tramadol can be decreased when combined with Loperamide.
Promethazine	Promethazine The risk or severity of serotonin syndrome can be increased when Promethazine is combined with Tramadol.
Meclofenamate	Meclofenamate Meclofenamic acid may decrease the excretion rate of Tramadol which could result in a higher serum level.
Daunorubicin	Daunorubicin The metabolism of Tramadol can be decreased when combined with Daunorubicin.
Nitrofurantoin	Nitrofurantoin Tramadol may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Griseofulvin	Griseofulvin The metabolism of Tramadol can be increased when combined with Griseofulvin.
Digoxin	Digoxin The risk or severity of adverse effects can be increased when Tramadol is combined with Digoxin.
Loxapine	Loxapine The risk or severity of serotonin syndrome can be increased when Loxapine is combined with Tramadol.
Chloroquine	Chloroquine The metabolism of Chloroquine can be decreased when combined with Tramadol.
Quinine	Quinine The metabolism of Tramadol can be decreased when combined with Quinine.
Ethosuximide	Ethosuximide The risk or severity of CNS depression can be increased when Ethosuximide is combined with Tramadol.
Calcitriol	Calcitriol The metabolism of Tramadol can be increased when combined with Calcitriol.
Triamterene	Triamterene The therapeutic efficacy of Triamterene can be decreased when used in combination with Tramadol.
Lactulose	Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Tramadol.
Sulfinpyrazone	Sulfinpyrazone The metabolism of Tramadol can be increased when combined with Sulfinpyrazone.
Chlorothiazide	Chlorothiazide The therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Tramadol.
Chlorthalidone	Chlorthalidone The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Tramadol.
Metolazone	Metolazone Tramadol may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide	Isosorbide The therapeutic efficacy of Isosorbide can be decreased when used in combination with Tramadol.
Secobarbital	Secobarbital The metabolism of Tramadol can be increased when combined with Secobarbital.
Desipramine	Desipramine The risk or severity of serotonin syndrome can be increased when Desipramine is combined with Tramadol.
Amitriptyline	Amitriptyline The risk or severity of serotonin syndrome can be increased when Amitriptyline is combined with Tramadol.
Imipramine	Imipramine The risk or severity of serotonin syndrome can be increased when Imipramine is combined with Tramadol.
Probenecid	Probenecid The metabolism of Tramadol can be increased when combined with Probenecid.
Quinidine	Quinidine The metabolism of Quinidine can be decreased when combined with Tramadol.
Procainamide	Procainamide The metabolism of Procainamide can be decreased when combined with Tramadol.
Isoniazid	Isoniazid The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Isoniazid.
Pyrazinamide	Pyrazinamide Tramadol may decrease the excretion rate of Pyrazinamide which could result in a higher serum level.
Rifampin	Rifampin The metabolism of Tramadol can be increased when combined with Rifampicin.
Disopyramide	Disopyramide The risk or severity of adverse effects can be increased when Tramadol is combined with Disopyramide.
Valproic Acid	Valproic Acid The risk or severity of serotonin syndrome can be increased when Valproic acid is combined with Tramadol.
Tamoxifen	Tamoxifen The metabolism of Tramadol can be decreased when combined with Tamoxifen.
Butabarbital	Butabarbital The risk or severity of CNS depression can be increased when Butabarbital is combined with Tramadol.
Liothyronine	Liothyronine Tramadol may decrease the excretion rate of Liothyronine which could result in a higher serum level.
Methimazole	Methimazole The metabolism of Tramadol can be decreased when combined with Methimazole.
Chlorpropamide	Chlorpropamide Tramadol may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
Glucagon Injection	Glucagon Injection Tramadol may increase the gastrointestinal motility reducing activities of Glucagon.
Tolbutamide	Tolbutamide Tramadol may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolazamide	Tolazamide Tramadol may decrease the excretion rate of Tolazamide which could result in a higher serum level.
Dextromethorphan	Dextromethorphan The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Dextromethorphan.
Cyclobenzaprine	Cyclobenzaprine The risk or severity of serotonin syndrome and seizure can be increased when Cyclobenzaprine is combined with Tramadol.
Niacin	Niacin The metabolism of Tramadol can be decreased when combined with Niacin.
Baclofen	Baclofen The risk or severity of CNS depression can be increased when Baclofen is combined with Tramadol.
Doxylamine	Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Tramadol.
Cyproheptadine	Cyproheptadine The risk or severity of CNS depression can be increased when Tramadol is combined with Cyproheptadine.
Clemastine	Clemastine The metabolism of Tramadol can be decreased when combined with Clemastine.
Chlorpheniramine	Chlorpheniramine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Chlorpheniramine.
Brompheniramine	Brompheniramine The risk or severity of CNS depression can be increased when Tramadol is combined with Brompheniramine.
Meclizine	Meclizine The risk or severity of CNS depression can be increased when Meclizine is combined with Tramadol.
Ethambutol	Ethambutol Tramadol may decrease the excretion rate of Ethambutol which could result in a higher serum level.
Methyclothiazide	Methyclothiazide The therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Tramadol.
Hydrochlorothiazide	Hydrochlorothiazide The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Tramadol.
Dantrolene	Dantrolene The risk or severity of CNS depression can be increased when Dantrolene is combined with Tramadol.
Chlorzoxazone	Chlorzoxazone The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Tramadol.
Carisoprodol	Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Tramadol.
Methocarbamol	Methocarbamol The risk or severity of CNS depression can be increased when Methocarbamol is combined with Tramadol.
Pyridoxine	Pyridoxine Pyridoxine may decrease the excretion rate of Tramadol which could result in a higher serum level.
Folic Acid	Folic Acid Folic acid may decrease the excretion rate of Tramadol which could result in a higher serum level.
Danazol	Danazol The metabolism of Tramadol can be decreased when combined with Danazol.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The metabolism of Tramadol can be decreased when combined with Propranolol.
Pseudoephedrine	Pseudoephedrine The risk or severity of serotonin syndrome can be increased when Pseudoephedrine is combined with Tramadol.
Nortriptyline	Nortriptyline The risk or severity of serotonin syndrome can be increased when Nortriptyline is combined with Tramadol.
Spironolactone	Spironolactone The therapeutic efficacy of Spironolactone can be decreased when used in combination with Tramadol.
Amphotericin B Injection	Amphotericin B Injection The metabolism of Tramadol can be decreased when combined with Amphotericin B.
Phytonadione	Phytonadione Tramadol may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection	Amikacin Injection Amikacin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Nadolol	Nadolol Tramadol may decrease the excretion rate of Nadolol which could result in a higher serum level.
Butorphanol Injection	Butorphanol Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Butorphanol.
Nalbuphine Injection	Nalbuphine Injection The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Nalbuphine.
Allopurinol	Allopurinol Tramadol may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Trimethobenzamide	Trimethobenzamide The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Tramadol.
Flavoxate	Flavoxate The risk or severity of adverse effects can be increased when Tramadol is combined with Flavoxate.
Colchicine	Colchicine The metabolism of Tramadol can be decreased when combined with Colchicine.
Cefaclor	Cefaclor Cefaclor may decrease the excretion rate of Tramadol which could result in a higher serum level.
Cefadroxil	Cefadroxil Cefadroxil may decrease the excretion rate of Tramadol which could result in a higher serum level.
Cefazolin Injection	Cefazolin Injection Cefazolin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Cephalexin	Cephalexin Cephalexin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Cefoxitin Injection	Cefoxitin Injection Cefoxitin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Dacarbazine	Dacarbazine Tramadol may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Acetazolamide	Acetazolamide The metabolism of Tramadol can be decreased when combined with Acetazolamide.
Cefotaxime Injection	Cefotaxime Injection Cefotaxime may decrease the excretion rate of Tramadol which could result in a higher serum level.
Calcitonin Salmon Injection	Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Ketoconazole	Ketoconazole The metabolism of Tramadol can be decreased when combined with Ketoconazole.
Pyrantel	Pyrantel The risk or severity of CNS depression can be increased when Pyrantel is combined with Tramadol.
Thiotepa Injection	Thiotepa Injection The metabolism of Tramadol can be decreased when combined with Thiotepa.
Isoxsuprine	Isoxsuprine The risk or severity of Tachycardia can be increased when Tramadol is combined with Isoxsuprine.
Vinblastine	Vinblastine The metabolism of Tramadol can be decreased when combined with Vinblastine.
Ethacrynic Acid	Ethacrynic Acid The therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Tramadol.
Colistimethate Injection	Colistimethate Injection Colistimethate may decrease the excretion rate of Tramadol which could result in a higher serum level.
Metoprolol	Metoprolol The metabolism of Metoprolol can be decreased when combined with Tramadol.
Hydroxyzine	Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tramadol.
Thiothixene	Thiothixene The metabolism of Tramadol can be decreased when combined with Thiothixene.
Aspirin	Aspirin Acetylsalicylic acid may decrease the excretion rate of Tramadol which could result in a higher serum level.
Salsalate	Salsalate Salsalate may decrease the excretion rate of Tramadol which could result in a higher serum level.
Alprazolam	Alprazolam The risk or severity of CNS depression can be increased when Tramadol is combined with Alprazolam.
Temazepam	Temazepam The risk or severity of CNS depression can be increased when Tramadol is combined with Temazepam.
Triazolam	Triazolam The risk or severity of CNS depression can be increased when Tramadol is combined with Triazolam.
Dicyclomine	Dicyclomine The risk or severity of adverse effects can be increased when Tramadol is combined with Dicyclomine.
Hyoscyamine	Hyoscyamine The risk or severity of adverse effects can be increased when Tramadol is combined with Hyoscyamine.
Propantheline	Propantheline The risk or severity of adverse effects can be increased when Tramadol is combined with Propantheline.
Trimethoprim	Trimethoprim Tramadol may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Diltiazem	Diltiazem The metabolism of Tramadol can be decreased when combined with Diltiazem.
Nifedipine	Nifedipine The metabolism of Nifedipine can be increased when combined with Tramadol.
Timolol	Timolol Tramadol may decrease the excretion rate of Timolol which could result in a higher serum level.
Verapamil	Verapamil The metabolism of Tramadol can be decreased when combined with Verapamil.
Atenolol	Atenolol The metabolism of Atenolol can be decreased when combined with Tramadol.
Pindolol	Pindolol The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Pindolol.
Cisplatin Injection	Cisplatin Injection Cisplatin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Diflunisal	Diflunisal Diflunisal may decrease the excretion rate of Tramadol which could result in a higher serum level.
Piroxicam	Piroxicam Piroxicam may decrease the excretion rate of Tramadol which could result in a higher serum level.
Bumetanide	Bumetanide Tramadol may increase the excretion rate of Bumetanide which could result in a lower serum level and potentially a reduction in efficacy.
Etoposide	Etoposide The metabolism of Tramadol can be decreased when combined with Etoposide.
Glyburide	Glyburide The metabolism of Tramadol can be decreased when combined with Glyburide.
Glipizide	Glipizide Tramadol may decrease the excretion rate of Glipizide which could result in a higher serum level.
Indapamide	Indapamide Tramadol may increase the excretion rate of Indapamide which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin	Amoxicillin Tramadol may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Dicloxacillin	Dicloxacillin The metabolism of Tramadol can be increased when combined with Dicloxacillin.
Nafcillin Injection	Nafcillin Injection The metabolism of Tramadol can be increased when combined with Nafcillin.
Oxacillin Injection	Oxacillin Injection Tramadol may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline	Pentoxifylline Tramadol may decrease the excretion rate of Pentoxifylline which could result in a higher serum level.
Pentamidine Injection	Pentamidine Injection Pentamidine may decrease the excretion rate of Tramadol which could result in a higher serum level.
Ceftriaxone Injection	Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Tramadol which could result in a higher serum level.
Labetalol	Labetalol The metabolism of Tramadol can be decreased when combined with Labetalol.
Auranofin	Auranofin Tramadol may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection	Leuprolide Injection Leuprolide may decrease the excretion rate of Tramadol which could result in a higher serum level.
Gemfibrozil	Gemfibrozil The metabolism of Tramadol can be decreased when combined with Gemfibrozil.
Guanabenz	Guanabenz The risk or severity of Tachycardia can be increased when Tramadol is combined with Guanabenz.
Dipivefrin Ophthalmic	Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Tramadol which could result in a higher serum level.
Ceftazidime Injection	Ceftazidime Injection Ceftazidime may decrease the excretion rate of Tramadol which could result in a higher serum level.
Ketoprofen	Ketoprofen Ketoprofen may decrease the excretion rate of Tramadol which could result in a higher serum level.
Cefotetan Injection	Cefotetan Injection Cefotetan may decrease the excretion rate of Tramadol which could result in a higher serum level.
Pimozide	Pimozide The metabolism of Pimozide can be decreased when combined with Tramadol.
Flurbiprofen	Flurbiprofen The metabolism of Tramadol can be decreased when combined with Flurbiprofen.
Amiodarone	Amiodarone The metabolism of Amiodarone can be decreased when combined with Tramadol.
Aztreonam Injection	Aztreonam Injection Tramadol may decrease the excretion rate of Aztreonam which could result in a higher serum level.
Buspirone	Buspirone The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Buspirone.
Lovastatin	Lovastatin The metabolism of Lovastatin can be decreased when combined with Tramadol.
Ciprofloxacin	Ciprofloxacin The metabolism of Ciprofloxacin can be decreased when combined with Tramadol.
Mesalamine	Mesalamine Mesalazine may decrease the excretion rate of Tramadol which could result in a higher serum level.
Diclofenac	Diclofenac Diclofenac may decrease the excretion rate of Tramadol which could result in a higher serum level.
Fluoxetine	Fluoxetine The risk or severity of serotonin syndrome can be increased when Fluoxetine is combined with Tramadol.
Clozapine	Clozapine The metabolism of Clozapine can be decreased when combined with Tramadol.
Estazolam	Estazolam The risk or severity of CNS depression can be increased when Tramadol is combined with Estazolam.
Idarubicin	Idarubicin The metabolism of Idarubicin can be decreased when combined with Tramadol.
Didanosine	Didanosine Tramadol may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection	Pentostatin Injection Tramadol may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Clarithromycin	Clarithromycin The metabolism of Tramadol can be decreased when combined with Clarithromycin.
Etodolac	Etodolac Etodolac may decrease the excretion rate of Tramadol which could result in a higher serum level.
Felodipine	Felodipine The metabolism of Felodipine can be decreased when combined with Tramadol.
Fosinopril	Fosinopril Tramadol may decrease the excretion rate of Fosinopril which could result in a higher serum level.
Nabumetone	Nabumetone Nabumetone may decrease the excretion rate of Tramadol which could result in a higher serum level.
Simvastatin	Simvastatin The metabolism of Simvastatin can be increased when combined with Tramadol.
Teniposide Injection	Teniposide Injection The metabolism of Teniposide can be decreased when combined with Tramadol.
Itraconazole	Itraconazole The metabolism of Tramadol can be decreased when combined with Itraconazole.
Lisinopril	Lisinopril Tramadol may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Oxaprozin	Oxaprozin Oxaprozin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Rifabutin	Rifabutin The metabolism of Tramadol can be increased when combined with Rifabutin.
Sotalol	Sotalol The metabolism of Sotalol can be decreased when combined with Tramadol.
Bisoprolol	Bisoprolol Tramadol may decrease the excretion rate of Bisoprolol which could result in a higher serum level.
Zolpidem	Zolpidem Tramadol may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin	Doxazosin The metabolism of Doxazosin can be decreased when combined with Tramadol.
Isradipine	Isradipine The metabolism of Tramadol can be decreased when combined with Isradipine.
Omeprazole	Omeprazole The metabolism of Tramadol can be decreased when combined with Omeprazole.
Cisapride	Cisapride The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Cisapride.
Gabapentin	Gabapentin The risk or severity of CNS depression can be increased when Gabapentin is combined with Tramadol.
Fluvastatin	Fluvastatin The metabolism of Tramadol can be decreased when combined with Fluvastatin.
Venlafaxine	Venlafaxine The risk or severity of serotonin syndrome can be increased when Venlafaxine is combined with Tramadol.
Nizatidine	Nizatidine The therapeutic efficacy of Tramadol can be decreased when used in combination with Nizatidine.
Fluvoxamine	Fluvoxamine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Fluvoxamine.
Nefazodone	Nefazodone The risk or severity of serotonin syndrome can be increased when Nefazodone is combined with Tramadol.
Lamotrigine	Lamotrigine The risk or severity of CNS depression can be increased when Lamotrigine is combined with Tramadol.
Losartan	Losartan The metabolism of Tramadol can be decreased when combined with Losartan.
Valacyclovir	Valacyclovir Valaciclovir may decrease the excretion rate of Tramadol which could result in a higher serum level.
Vinorelbine Injection	Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Tramadol.
Carboplatin Injection	Carboplatin Injection Carboplatin may decrease the excretion rate of Tramadol which could result in a higher serum level.
Lansoprazole	Lansoprazole The metabolism of Tramadol can be decreased when combined with Lansoprazole.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Tramadol.
Nicardipine	Nicardipine The metabolism of Tramadol can be decreased when combined with Nicardipine.
Bupropion	Bupropion The risk or severity of seizure can be increased when Bupropion is combined with Tramadol.
Ticlopidine	Ticlopidine The metabolism of Tramadol can be decreased when combined with Ticlopidine.
Saquinavir	Saquinavir The metabolism of Saquinavir can be decreased when combined with Tramadol.
Metformin	Metformin Tramadol may decrease the excretion rate of Metformin which could result in a higher serum level.
Nisoldipine	Nisoldipine Tramadol may decrease the excretion rate of Nisoldipine which could result in a higher serum level.
Lamivudine	Lamivudine Tramadol may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole	Riluzole The risk or severity of CNS depression can be increased when Riluzole is combined with Tramadol.
Acarbose	Acarbose Tramadol may decrease the excretion rate of Acarbose which could result in a higher serum level.
Gemcitabine Injection	Gemcitabine Injection Tramadol may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Indinavir	Indinavir The metabolism of Indinavir can be decreased when combined with Tramadol.
Ritonavir	Ritonavir The serum concentration of Tramadol can be increased when it is combined with Ritonavir.
Docetaxel Injection	Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Tramadol.
Cidofovir Injection	Cidofovir Injection Cidofovir may decrease the excretion rate of Tramadol which could result in a higher serum level.
Meropenem Injection	Meropenem Injection Tramadol may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine	Clomipramine The risk or severity of serotonin syndrome can be increased when Clomipramine is combined with Tramadol.
Zafirlukast	Zafirlukast The metabolism of Tramadol can be decreased when combined with Zafirlukast.
Fosfomycin	Fosfomycin Tramadol may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine	Mirtazapine Tramadol may increase the serotonergic activities of Mirtazapine.
Topiramate	Topiramate The risk or severity of hyperthermia and oligohydrosis can be increased when Tramadol is combined with Topiramate.
Pramipexole	Pramipexole Tramadol may increase the sedative activities of Pramipexole.
Donepezil	Donepezil The therapeutic efficacy of Tramadol can be decreased when used in combination with Donepezil.
Nelfinavir	Nelfinavir The metabolism of Nelfinavir can be decreased when combined with Tramadol.
Loratadine	Loratadine Tramadol may increase the anticholinergic activities of Loratadine.
Carvedilol	Carvedilol The metabolism of Carvedilol can be decreased when combined with Tramadol.
Nilutamide	Nilutamide Tramadol may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Flutamide	Flutamide Tramadol may decrease the excretion rate of Flutamide which could result in a higher serum level.
Selegiline	Selegiline The risk or severity of serotonin syndrome and seizure can be increased when Selegiline is combined with Tramadol.
Bicalutamide	Bicalutamide The metabolism of Tramadol can be decreased when combined with Bicalutamide.
Sertraline	Sertraline The risk or severity of serotonin syndrome can be increased when Sertraline is combined with Tramadol.
Propafenone	Propafenone The metabolism of Tramadol can be decreased when combined with Propafenone.
Raloxifene	Raloxifene The metabolism of Tramadol can be decreased when combined with Raloxifene.
Irbesartan	Irbesartan The metabolism of Tramadol can be decreased when combined with Irbesartan.
Tamsulosin	Tamsulosin Tramadol may decrease the excretion rate of Tamsulosin which could result in a higher serum level.
Ropinirole	Ropinirole The risk or severity of CNS depression can be increased when Tramadol is combined with Ropinirole.
Quetiapine	Quetiapine The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Quetiapine.
Cefepime Injection	Cefepime Injection Cefepime may decrease the excretion rate of Tramadol which could result in a higher serum level.
Cefprozil	Cefprozil Cefprozil may decrease the excretion rate of Tramadol which could result in a higher serum level.
Cefpodoxime	Cefpodoxime Cefpodoxime may decrease the excretion rate of Tramadol which could result in a higher serum level.
Cetirizine	Cetirizine The risk or severity of CNS depression can be increased when Cetirizine is combined with Tramadol.
Paroxetine	Paroxetine The risk or severity of serotonin syndrome can be increased when Paroxetine is combined with Tramadol.
Tolcapone	Tolcapone The risk or severity of CNS depression can be increased when Tolcapone is combined with Tramadol.
Citalopram	Citalopram The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Citalopram.
Capecitabine	Capecitabine Tramadol may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Efavirenz	Efavirenz The metabolism of Tramadol can be decreased when combined with Efavirenz.
Abacavir	Abacavir Tramadol may decrease the excretion rate of Abacavir which could result in a higher serum level.
Sildenafil	Sildenafil The metabolism of Sildenafil can be decreased when combined with Tramadol.
Celecoxib	Celecoxib The metabolism of Tramadol can be decreased when combined with Celecoxib.
Rosiglitazone	Rosiglitazone The metabolism of Tramadol can be decreased when combined with Rosiglitazone.
Tolterodine	Tolterodine The risk or severity of adverse effects can be increased when Tramadol is combined with Tolterodine.
Thalidomide	Thalidomide Tramadol may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir	Oseltamivir Tramadol may decrease the excretion rate of Oseltamivir which could result in a higher serum level.
Balsalazide	Balsalazide Balsalazide may decrease the excretion rate of Tramadol which could result in a higher serum level.
Nateglinide	Nateglinide Tramadol may decrease the excretion rate of Nateglinide which could result in a higher serum level.
Galantamine	Galantamine The therapeutic efficacy of Tramadol can be decreased when used in combination with Galantamine.
Levetiracetam	Levetiracetam The risk or severity of CNS depression can be increased when Tramadol is combined with Levetiracetam.
Rabeprazole	Rabeprazole The metabolism of Rabeprazole can be decreased when combined with Tramadol.
Terbinafine	Terbinafine The metabolism of Tramadol can be decreased when combined with Terbinafine.