Amitriptyline

Generic name: Pronounced as (a mee trip' ti leen)
Brand names
  • Amitid®
  • Amitril®
  • Elavil®
  • Endep®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 07/15/2017

A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as amitriptyline during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take amitriptyline, but in some cases, a doctor may decide that amitriptyline is the best medication to treat a child's condition.

You should know that your mental health may change in unexpected ways when you take amitriptyline or other antidepressants even if you are an adult over age 24. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor when you are unable to seek treatment on your own.

Your healthcare provider will want to see you often while you are taking amitriptyline, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor.

The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with amitriptyline. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm.

No matter your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you.

Amitriptyline is used to treat symptoms of depression. Amitriptyline is in a class of medications called tricyclic antidepressants. It works by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance.

Amitriptyline comes as a tablet to take by mouth. It is usually taken one to four times a day. Take amitriptyline at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take amitriptyline exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of amitriptyline and gradually increase your dose.

It may take a few weeks or longer before you feel the full benefit of amitriptyline. Continue to take amitriptyline even if you feel well. Do not stop taking amitriptyline without talking to your doctor. If you suddenly stop taking amitriptyline, you may experience withdrawal symptoms such as nausea, headache, and lack of energy. Your doctor will probably decrease your dose gradually.

Amitriptyline is also used to treat eating disorders, post-herpetic neuralgia (the burning, stabbing pains, or aches that may last for months or years after a shingles infection), and to prevent migraine headaches. Talk to your doctor about the possible risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking amitriptyline,

  • tell your doctor and pharmacist if you are allergic to amitriptyline or any other medications.

  • tell your doctor if you are taking cisapride (Propulsid) (not available in the U.S.) or monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have taken an MAO inhibitor during the past 14 days. Your doctor will probably tell you that you should not take amitriptyline.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: antihistamines; cimetidine (Tagamet); diet pills; disulfiram (Antabuse); guanethidine (Ismelin); ipratropium (Atrovent); quinidine (Quinidex); medications for irregular heartbeats such as flecainide (Tambocor) and propafenone (Rythmol); medications for anxiety, asthma, colds, irritable bowel disease, mental illness, nausea, Parkinson's disease, seizures, ulcers, or urinary problems; other antidepressants; phenobarbital (Bellatal, Solfoton); sedatives; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft); sleeping pills; thyroid medications; and tranquilizers. Tell your doctor or pharmacist if you have stopped taking fluoxetine (Prozac, Sarafem) in the past 5 weeks.Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have recently had a heart attack. Your doctor will probably tell you not to take amitriptyline.

  • tell your doctor if you drink large amounts of alcohol and if you have or have ever had glaucoma (an eye condition); an enlarged prostate (a male reproductive gland); difficulty urinating; seizures; an overactive thyroid gland (hyperthyroidism); diabetes; schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions); or liver, kidney, or heart disease.

  • tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while taking amitriptyline, call your doctor. Do not breast-feed while you are taking amitriptyline.

  • talk to your doctor about the risks and benefits of taking this medication if you are 65 years of age or older. Older adults should not usually take amitriptyline because it is not as safe or effective as other medication(s) that can be used to treat the same condition.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking amitriptyline.

  • you should know that amitriptyline may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.

  • remember that alcohol can add to the drowsiness caused by this medication.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Amitriptyline may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • drowsiness

    • weakness or tiredness

    • nightmares

    • headaches

    • dry mouth

    • constipation

    • difficulty urinating

    • blurred vision

    • pain, burning, or tingling in the hands or feet

    • changes in sex drive or ability

    • excessive sweating

    • changes in appetite or weight

    • confusion

    • unsteadiness

  • Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

    • slow or difficult speech

    • dizziness or faintness

    • weakness or numbness of an arm or a leg

    • crushing chest pain

    • rapid, pounding, or irregular heartbeat

    • severe skin rash or hives

    • swelling of the face and tongue

    • yellowing of the skin or eyes

    • jaw, neck, and back muscle spasms

    • uncontrollable shaking of a part of the body

    • fainting

    • unusual bleeding or bruising

    • seizures

    • hallucinating (seeing things or hearing voices that do not exist)

  • Amitriptyline may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • irregular heartbeat

  • seizures

  • coma (loss of consciousness for a period of time)

  • confusion

  • problems concentrating

  • hallucinating (seeing things or hearing voices that do not exist)

  • agitation

  • drowsiness

  • rigid muscles

  • vomiting

  • fever

  • cold body temperature

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to amitriptyline.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Duo-Vil® (containing Amitriptyline, Perphenazine)
  • Etrafon® (containing Amitriptyline, Perphenazine)
  • Limbitrol® (containing Amitriptyline, Chlordiazepoxide)
  • Triavil® (containing Amitriptyline, Perphenazine)

Drug Interaction
Moxifloxacin Moxifloxacin Moxifloxacin may increase the QTc-prolonging activities of Amitriptyline.
Repaglinide Repaglinide The metabolism of Repaglinide can be decreased when combined with Amitriptyline.
Montelukast Montelukast The metabolism of Amitriptyline can be decreased when combined with Montelukast.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The metabolism of Amitriptyline can be increased when combined with Insulin glargine.
Leflunomide Leflunomide The serum concentration of Amitriptyline can be decreased when it is combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Amitriptyline can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Amitriptyline can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Amitriptyline.
Dolasetron Dolasetron The metabolism of Amitriptyline can be decreased when combined with Dolasetron.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Amitriptyline.
Anagrelide Anagrelide The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Anagrelide.
Bisacodyl Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Amitriptyline.
Candesartan Candesartan The metabolism of Amitriptyline can be decreased when combined with Candesartan.
Cilostazol Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Amitriptyline.
Clopidogrel Clopidogrel The metabolism of Amitriptyline can be decreased when combined with Clopidogrel.
Diphenoxylate Diphenoxylate The risk or severity of adverse effects can be increased when Amitriptyline is combined with Diphenoxylate.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Amitriptyline can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The metabolism of Amitriptyline can be decreased when combined with Conjugated estrogens.
Fenofibrate Fenofibrate The metabolism of Amitriptyline can be decreased when combined with Fenofibrate.
Guanfacine Guanfacine Guanfacine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Magnesium Hydroxide Magnesium Hydroxide Amitriptyline may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Magnesium Oxide Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Amitriptyline.
Methylergonovine Methylergonovine The risk or severity of hypertension can be increased when Amitriptyline is combined with Methylergometrine.
Miglitol Miglitol Amitriptyline may decrease the hypoglycemic activities of Miglitol.
Mycophenolate Mycophenolate The metabolism of Mycophenolic acid can be decreased when combined with Amitriptyline.
Naratriptan Naratriptan The risk or severity of adverse effects can be increased when Amitriptyline is combined with Naratriptan.
Olsalazine Olsalazine Amitriptyline may decrease the excretion rate of Olsalazine which could result in a higher serum level.
Paregoric Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Amitriptyline.
Penbutolol Penbutolol The metabolism of Amitriptyline can be decreased when combined with Acebutolol.
Pentazocine Pentazocine The risk or severity of adverse effects can be increased when Pentazocine is combined with Amitriptyline.
Polyethylene glycol-electrolyte solution (PEG-ES) Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Amitriptyline.
Potassium Potassium Potassium may increase the excretion rate of Amitriptyline which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone Amitriptyline may decrease the excretion rate of Prednisone which could result in a higher serum level.
Psyllium Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Amitriptyline.
Ranitidine Ranitidine The metabolism of Amitriptyline can be decreased when combined with Ranitidine.
Reserpine Reserpine Reserpine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Rizatriptan Rizatriptan Rizatriptan may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Sumatriptan Sumatriptan Sumatriptan may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Tacrolimus Tacrolimus The metabolism of Tacrolimus can be decreased when combined with Amitriptyline.
Tizanidine Tizanidine Tizanidine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Triamcinolone Triamcinolone The metabolism of Amitriptyline can be increased when combined with Triamcinolone.
Zolmitriptan Zolmitriptan The metabolism of Amitriptyline can be decreased when combined with Zolmitriptan.
Ampicillin Injection Ampicillin Injection Amitriptyline may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Famotidine Injection Famotidine Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Amitriptyline.
Fluconazole Injection Fluconazole Injection Amitriptyline may increase the QTc-prolonging activities of Fluconazole.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection The risk or severity of adverse effects can be increased when Amitriptyline is combined with Hydromorphone.
Interferon Beta-1b Injection Interferon Beta-1b Injection The metabolism of Amitriptyline can be decreased when combined with Interferon beta-1b.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The metabolism of Amitriptyline can be decreased when combined with Interferon gamma-1b.
Levofloxacin Injection Levofloxacin Injection Levofloxacin may increase the QTc-prolonging activities of Amitriptyline.
Meperidine Injection Meperidine Injection The risk or severity of adverse effects can be increased when Meperidine is combined with Amitriptyline.
Metoclopramide Injection Metoclopramide Injection The metabolism of Amitriptyline can be decreased when combined with Metoclopramide.
Metronidazole Injection Metronidazole Injection The metabolism of Amitriptyline can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Amitriptyline.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Amitriptyline may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The metabolism of Amitriptyline can be increased when combined with Zidovudine.
Altretamine Altretamine Amphetamine may decrease the sedative and stimulatory activities of Amitriptyline.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Cyclosporine Cyclosporine The metabolism of Amitriptyline can be decreased when combined with Cyclosporine.
Ondansetron Ondansetron The metabolism of Ondansetron can be decreased when combined with Amitriptyline.
Granisetron Granisetron The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Granisetron.
Torsemide Torsemide The metabolism of Amitriptyline can be decreased when combined with Torasemide.
Olanzapine Olanzapine Olanzapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Amitriptyline.
Alosetron Alosetron Amitriptyline may increase the central nervous system depressant (CNS depressant) activities of Alosetron.
Dofetilide Dofetilide The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Dofetilide.
Entacapone Entacapone The metabolism of Amitriptyline can be decreased when combined with Entacapone.
Eprosartan Eprosartan Amitriptyline may decrease the antihypertensive activities of Eprosartan.
Hydroxychloroquine Hydroxychloroquine The metabolism of Amitriptyline can be decreased when combined with Hydroxychloroquine.
Meloxicam Meloxicam Amitriptyline may decrease the excretion rate of Meloxicam which could result in a higher serum level.
Oxcarbazepine Oxcarbazepine Oxcarbazepine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Pantoprazole Pantoprazole The metabolism of Amitriptyline can be decreased when combined with Pantoprazole.
Telmisartan Telmisartan The metabolism of Amitriptyline can be decreased when combined with Telmisartan.
Temozolomide Temozolomide Amitriptyline may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon Zaleplon Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Anakinra Anakinra The metabolism of Amitriptyline can be increased when combined with Anakinra.
Desloratadine Desloratadine Desloratadine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Linezolid Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Amitriptyline.
Rivastigmine Rivastigmine The therapeutic efficacy of Amitriptyline can be decreased when used in combination with Rivastigmine.
Trimipramine Trimipramine Trimipramine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Amitriptyline.
Etanercept Injection Etanercept Injection The metabolism of Amitriptyline can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate The risk or severity of adverse effects can be increased when Amitriptyline is combined with Glycopyrronium.
Modafinil Modafinil The metabolism of Amitriptyline can be decreased when combined with Modafinil.
Perindopril Perindopril Amitriptyline may decrease the antihypertensive activities of Perindopril.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Amitriptyline may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Amitriptyline.
Dutasteride Dutasteride The metabolism of Dutasteride can be decreased when combined with Amitriptyline.
Epinephrine Injection Epinephrine Injection Epinephrine may increase the vasopressor activities of Amitriptyline.
Eplerenone Eplerenone Amitriptyline may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram Escitalopram The metabolism of Amitriptyline can be decreased when combined with Escitalopram.
Olmesartan Olmesartan Amitriptyline may decrease the antihypertensive activities of Olmesartan.
Zonisamide Zonisamide Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Adalimumab Injection Adalimumab Injection The metabolism of Amitriptyline can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole Amitriptyline may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole.
Atomoxetine Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Amitriptyline.
Dexmethylphenidate Dexmethylphenidate The serum concentration of Amitriptyline can be increased when it is combined with Dexmethylphenidate.
Ezetimibe Ezetimibe The metabolism of Ezetimibe can be decreased when combined with Amitriptyline.
Atazanavir Atazanavir The metabolism of Amitriptyline can be decreased when combined with Atazanavir.
Almotriptan Almotriptan The metabolism of Amitriptyline can be decreased when combined with Almotriptan.
Eletriptan Eletriptan The metabolism of Amitriptyline can be decreased when combined with Eletriptan.
Mefloquine Mefloquine The metabolism of Amitriptyline can be decreased when combined with Mefloquine.
Polyethylene Glycol 3350 Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Amitriptyline.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Amitriptyline.
Vardenafil Vardenafil The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Vardenafil.
Alfuzosin Alfuzosin Alfuzosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Amitriptyline.
Aprepitant Aprepitant The metabolism of Amitriptyline can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine Amitriptyline may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Interferon Beta-1a Subcutaneous Injection Interferon Beta-1a Subcutaneous Injection The metabolism of Amitriptyline can be decreased when combined with Interferon beta-1a.
Memantine Memantine The metabolism of Amitriptyline can be decreased when combined with Memantine.
Tegaserod Tegaserod The metabolism of Amitriptyline can be decreased when combined with Tegaserod.
Tadalafil Tadalafil The risk or severity of hypotension, dyspepsia, and headache can be increased when Amitriptyline is combined with Tadalafil.
Frovatriptan Frovatriptan The metabolism of Frovatriptan can be decreased when combined with Amitriptyline.
Gemifloxacin Gemifloxacin Gemifloxacin may increase the QTc-prolonging activities of Amitriptyline.
Progesterone Progesterone The metabolism of Amitriptyline can be decreased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The risk or severity of adverse effects can be increased when Amitriptyline is combined with Apomorphine.
Infliximab Injection Infliximab Injection The metabolism of Amitriptyline can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Amitriptyline can be decreased when combined with Oxandrolone.
Protriptyline Protriptyline The metabolism of Amitriptyline can be decreased when combined with Protriptyline.
Rifaximin Rifaximin The metabolism of Amitriptyline can be increased when combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Amitriptyline can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Norethisterone can be decreased when combined with Amitriptyline.
Tinidazole Tinidazole Amitriptyline may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Trospium Trospium The metabolism of Amitriptyline can be decreased when combined with Trospium.
Bosentan Bosentan The metabolism of Amitriptyline can be increased when combined with Bosentan.
Cefditoren Cefditoren Amitriptyline may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cinacalcet Cinacalcet The metabolism of Amitriptyline can be decreased when combined with Cinacalcet.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Amitriptyline.
Eszopiclone Eszopiclone The risk or severity of CNS depression can be increased when Amitriptyline is combined with Eszopiclone.
Ganciclovir Ganciclovir Amitriptyline may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Insulin Aspart (rDNA Origin) Injection Insulin Aspart (rDNA Origin) Injection Amitriptyline may decrease the hypoglycemic activities of Insulin aspart.
Ribavirin Ribavirin Amitriptyline may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Solifenacin Solifenacin The metabolism of Solifenacin can be decreased when combined with Amitriptyline.
Valganciclovir Valganciclovir Amitriptyline may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole Voriconazole The metabolism of Amitriptyline can be decreased when combined with Voriconazole.
Adefovir Adefovir Adefovir may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Amphetamine may decrease the sedative and stimulatory activities of Amitriptyline.
Entecavir Entecavir The metabolism of Entecavir can be decreased when combined with Amitriptyline.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The metabolism of Amitriptyline can be decreased when combined with Peginterferon alfa-2a.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Amitriptyline can be decreased when combined with Peginterferon alfa-2b.
Pramlintide Injection Pramlintide Injection The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Amitriptyline.
Sodium Oxybate Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Exenatide Injection Exenatide Injection Amitriptyline may decrease the hypoglycemic activities of Exenatide.
Ibandronate Ibandronate The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Amitriptyline.
Isocarboxazid Isocarboxazid Amitriptyline may increase the serotonergic activities of Isocarboxazid.
Ramelteon Ramelteon Amitriptyline may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.
Darifenacin Darifenacin The metabolism of Amitriptyline can be decreased when combined with Darifenacin.
Fentanyl Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Amitriptyline.
Pregabalin Pregabalin The therapeutic efficacy of Amitriptyline can be increased when used in combination with Pregabalin.
Deferasirox Deferasirox The serum concentration of Amitriptyline can be increased when it is combined with Deferasirox.
Phenylephrine Phenylephrine Amitriptyline may increase the vasopressor activities of Phenylephrine.
Tipranavir Tipranavir The metabolism of Amitriptyline can be decreased when combined with Tipranavir.
Felbamate Felbamate The metabolism of Amitriptyline can be decreased when combined with Felbamate.
Insulin Detemir (rDNA Origin) Injection Insulin Detemir (rDNA Origin) Injection Amitriptyline may decrease the hypoglycemic activities of Insulin detemir.
Ranolazine Ranolazine The metabolism of Ranolazine can be decreased when combined with Amitriptyline.
Abatacept Injection Abatacept Injection The metabolism of Amitriptyline can be increased when combined with Abatacept.
Rasagiline Rasagiline Rasagiline may increase the serotonergic activities of Amitriptyline.
Imatinib Imatinib The metabolism of Amitriptyline can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The metabolism of Sitagliptin can be decreased when combined with Amitriptyline.
Varenicline Varenicline Amitriptyline may decrease the excretion rate of Varenicline which could result in a higher serum level.
Gefitinib Gefitinib The metabolism of Amitriptyline can be decreased when combined with Gefitinib.
Albuterol Albuterol The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Salbutamol.
Paliperidone Paliperidone Paliperidone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Amitriptyline.
Bortezomib Bortezomib The metabolism of Amitriptyline can be decreased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection Amitriptyline may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Fulvestrant Injection Fulvestrant Injection The metabolism of Fulvestrant can be decreased when combined with Amitriptyline.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The metabolism of Amitriptyline can be increased when combined with Insulin glulisine.
Lubiprostone Lubiprostone Amitriptyline may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Oxaliplatin.
Posaconazole Posaconazole The risk or severity of QTc prolongation can be increased when Posaconazole is combined with Amitriptyline.
Primaquine Primaquine The metabolism of Amitriptyline can be decreased when combined with Primaquine.
Aliskiren Aliskiren Amitriptyline may decrease the antihypertensive activities of Aliskiren.
Bismuth Subsalicylate Bismuth Subsalicylate Amitriptyline may increase the neurotoxic activities of Bismuth subsalicylate.
Darunavir Darunavir The metabolism of Darunavir can be decreased when combined with Amitriptyline.
Pemetrexed Injection Pemetrexed Injection Amitriptyline may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dimenhydrinate Dimenhydrinate Dimenhydrinate may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Lisdexamfetamine Lisdexamfetamine The metabolism of Amitriptyline can be decreased when combined with Lisdexamfetamine.
Nabilone Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Vorinostat Vorinostat The risk or severity of QTc prolongation can be increased when Vorinostat is combined with Amitriptyline.
Sorafenib Sorafenib The metabolism of Amitriptyline can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Sunitinib can be decreased when combined with Amitriptyline.
Dronabinol Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Lapatinib Lapatinib The metabolism of Amitriptyline can be decreased when combined with Lapatinib.
Levocetirizine Levocetirizine Levocetirizine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Pegaptanib Injection Pegaptanib Injection Amitriptyline may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Amitriptyline.
Mexiletine Mexiletine The metabolism of Amitriptyline can be decreased when combined with Mexiletine.
Armodafinil Armodafinil The metabolism of Amitriptyline can be decreased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection Amitriptyline may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Paclitaxel (with polyoxyethylated castor oil) Injection Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Amitriptyline.
Temsirolimus Temsirolimus The metabolism of Amitriptyline can be decreased when combined with Temsirolimus.
Lenalidomide Lenalidomide Amitriptyline may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Nilotinib Nilotinib The metabolism of Amitriptyline can be decreased when combined with Nilotinib.
Toremifene Toremifene The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Toremifene.
Raltegravir Raltegravir The metabolism of Raltegravir can be decreased when combined with Amitriptyline.
Bexarotene Bexarotene The metabolism of Amitriptyline can be decreased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Amitriptyline can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Amitriptyline can be decreased when combined with Chloramphenicol.
Desmopressin Desmopressin The risk or severity of hyponatremia and water intoxication can be increased when Amitriptyline is combined with Desmopressin.
Betaine Betaine The therapeutic efficacy of Amitriptyline can be decreased when used in combination with Glycine betaine.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Amitriptyline is combined with Botulinum toxin type A.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Amitriptyline is combined with Botulinum Toxin Type B.
Doripenem Injection Doripenem Injection Amitriptyline may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine Etravirine The metabolism of Amitriptyline can be decreased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Arsenic trioxide is combined with Amitriptyline.
Desvenlafaxine Desvenlafaxine The metabolism of Desvenlafaxine can be decreased when combined with Amitriptyline.
Cevimeline Cevimeline The metabolism of Cevimeline can be decreased when combined with Amitriptyline.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Amitriptyline.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Amitriptyline.
Bendamustine Injection Bendamustine Injection The metabolism of Bendamustine can be decreased when combined with Amitriptyline.
Flecainide Flecainide The metabolism of Flecainide can be decreased when combined with Amitriptyline.
Certolizumab Injection Certolizumab Injection The metabolism of Amitriptyline can be increased when combined with Certolizumab pegol.
Irinotecan Injection Irinotecan Injection The risk or severity of neutropenia can be increased when Amitriptyline is combined with Irinotecan.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Amitriptyline.
Methylnaltrexone Injection Methylnaltrexone Injection Amitriptyline may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Rufinamide Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Amitriptyline.
Silodosin Silodosin Silodosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Amitriptyline.
Midazolam Midazolam Midazolam may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Naltrexone Injection Naltrexone Injection The risk or severity of adverse effects can be increased when Amitriptyline is combined with Naltrexone.
Dexrazoxane Injection Dexrazoxane Injection Amitriptyline may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
Eltrombopag Eltrombopag The metabolism of Amitriptyline can be decreased when combined with Eltrombopag.
Milnacipran Milnacipran The risk or severity of adverse effects can be increased when Amitriptyline is combined with Milnacipran.
Dexlansoprazole Dexlansoprazole The metabolism of Amitriptyline can be decreased when combined with Dexlansoprazole.
Plerixafor Injection Plerixafor Injection Amitriptyline may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Sodium Phosphate Sodium Phosphate The risk or severity of seizure can be increased when Amitriptyline is combined with Sodium phosphate, monobasic.
Fesoterodine Fesoterodine The metabolism of Fesoterodine can be decreased when combined with Amitriptyline.
Degarelix Injection Degarelix Injection The risk or severity of QTc prolongation can be increased when Degarelix is combined with Amitriptyline.
Betaxolol Betaxolol The metabolism of Amitriptyline can be decreased when combined with Betaxolol.
Iloperidone Iloperidone Iloperidone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Amitriptyline.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Amitriptyline.
Lacosamide Lacosamide Amitriptyline may increase the central nervous system depressant (CNS depressant) activities of Lacosamide.
Everolimus Everolimus The metabolism of Amitriptyline can be decreased when combined with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Amitriptyline which could result in a lower serum level and potentially a reduction in efficacy.
Dronedarone Dronedarone Dronedarone may increase the QTc-prolonging activities of Amitriptyline.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Amitriptyline is combined with Botulinum toxin type A.
Pralatrexate Injection Pralatrexate Injection Amitriptyline may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection The metabolism of Amitriptyline can be decreased when combined with Palonosetron.
Saxagliptin Saxagliptin Amitriptyline may decrease the hypoglycemic activities of Saxagliptin.
Telavancin Injection Telavancin Injection The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Telavancin.
Romidepsin Injection Romidepsin Injection The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Romidepsin.
Tapentadol Tapentadol The metabolism of Amitriptyline can be decreased when combined with Tapentadol.
Topotecan Topotecan Amitriptyline may decrease the excretion rate of Topotecan which could result in a higher serum level.
Golimumab Injection Golimumab Injection The metabolism of Amitriptyline can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Amitriptyline.
Asenapine Asenapine The metabolism of Amitriptyline can be decreased when combined with Asenapine.
Vigabatrin Vigabatrin Vigabatrin may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Amitriptyline.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Amitriptyline.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be decreased when combined with Amitriptyline.
Oxymorphone Oxymorphone The risk or severity of adverse effects can be increased when Amitriptyline is combined with Oxymorphone.
Liraglutide Injection Liraglutide Injection Amitriptyline may decrease the hypoglycemic activities of Liraglutide.
Tocilizumab Injection Tocilizumab Injection The metabolism of Amitriptyline can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine The risk or severity of seizure can be increased when Dalfampridine is combined with Amitriptyline.
Eribulin Injection Eribulin Injection The risk or severity of QTc prolongation can be increased when Eribulin is combined with Amitriptyline.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Amitriptyline is combined with Botulinum toxin type A.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Amitriptyline.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Lurasidone Lurasidone Amitriptyline may increase the hypotensive activities of Lurasidone.
Acetaminophen Injection Acetaminophen Injection The metabolism of Amitriptyline can be decreased when combined with Acetaminophen.
Vilazodone Vilazodone The metabolism of Amitriptyline can be decreased when combined with Vilazodone.
Ipilimumab Injection Ipilimumab Injection Amitriptyline may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection The therapeutic efficacy of Amitriptyline can be decreased when used in combination with Terbutaline.
Roflumilast Roflumilast Amitriptyline may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Linagliptin Linagliptin Amitriptyline may decrease the hypoglycemic activities of Linagliptin.
Rilpivirine Rilpivirine The metabolism of Amitriptyline can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The metabolism of Amitriptyline can be decreased when combined with Glecaprevir.
Potassium Iodide Potassium Iodide The risk or severity of Cardiac Arrhythmia can be increased when Potassium Iodide is combined with Amitriptyline.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Amitriptyline.
Abiraterone Abiraterone The metabolism of Amitriptyline can be decreased when combined with Abiraterone.
Triptorelin Injection Triptorelin Injection The risk or severity of QTc prolongation can be increased when Triptorelin is combined with Amitriptyline.
Rivaroxaban Rivaroxaban Amitriptyline may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor Ticagrelor The metabolism of Amitriptyline can be decreased when combined with Ticagrelor.
Ruxolitinib Ruxolitinib Amitriptyline may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Vandetanib Vandetanib The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Vandetanib.
Clobazam Clobazam The metabolism of Amitriptyline can be decreased when combined with Clobazam.
Vemurafenib Vemurafenib The serum concentration of Amitriptyline can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Amitriptyline can be decreased when combined with Vismodegib.
Ivacaftor Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Amitriptyline.
Deferiprone Deferiprone Amitriptyline may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Amitriptyline.
Crizotinib Crizotinib The metabolism of Amitriptyline can be decreased when combined with Crizotinib.
Cabergoline Cabergoline Cabergoline may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Naloxone Injection Naloxone Injection The metabolism of Naloxone can be decreased when combined with Amitriptyline.
Ambrisentan Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Amitriptyline.
Fondaparinux Injection Fondaparinux Injection Amitriptyline may decrease the excretion rate of Fondaparinux which could result in a higher serum level.
Ezogabine Ezogabine Tiagabine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Enzalutamide Enzalutamide The metabolism of Amitriptyline can be increased when combined with Enzalutamide.
Mirabegron Mirabegron The risk or severity of urinary retention can be increased when Amitriptyline is combined with Mirabegron.
Regorafenib Regorafenib The metabolism of Amitriptyline can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Amitriptyline can be decreased when combined with Bosutinib.
Linaclotide Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Amitriptyline.
Teriflunomide Teriflunomide The serum concentration of Amitriptyline can be decreased when it is combined with Teriflunomide.
Lorcaserin Lorcaserin Amitriptyline may decrease the hypoglycemic activities of Mecasermin.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Amitriptyline.
Teduglutide Injection Teduglutide Injection Amitriptyline may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Bedaquiline Bedaquiline The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Bedaquiline.
Alogliptin Alogliptin The metabolism of Alogliptin can be decreased when combined with Amitriptyline.
Ponatinib Ponatinib The metabolism of Amitriptyline can be decreased when combined with Ponatinib.
Pomalidomide Pomalidomide Pomalidomide may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Amitriptyline.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Amitriptyline.
Canagliflozin Canagliflozin Amitriptyline may decrease the hypoglycemic activities of Canagliflozin.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Amitriptyline which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib Dabrafenib The serum concentration of Amitriptyline can be decreased when it is combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Amitriptyline can be decreased when combined with Ospemifene.
Trametinib Trametinib The metabolism of Amitriptyline can be decreased when combined with Trametinib.
Dolutegravir Dolutegravir The metabolism of Dolutegravir can be decreased when combined with Amitriptyline.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Amitriptyline.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Amitriptyline.
Perampanel Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Amitriptyline.
Avanafil Avanafil The risk or severity of hypotension, dyspepsia, and headache can be increased when Avanafil is combined with Amitriptyline.
Ketorolac Injection Ketorolac Injection The metabolism of Ketorolac can be decreased when combined with Amitriptyline.
Simeprevir Simeprevir The metabolism of Amitriptyline can be decreased when combined with Simeprevir.
Sofosbuvir Sofosbuvir Amitriptyline may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Amitriptyline.
Apremilast Apremilast The metabolism of Amitriptyline can be increased when combined with Apremilast.
Droxidopa Droxidopa Amitriptyline may increase the vasopressor activities of Droxidopa.
Ceritinib Ceritinib The metabolism of Amitriptyline can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Amitriptyline can be increased when combined with Siltuximab.
Albiglutide Injection Albiglutide Injection Amitriptyline may decrease the hypoglycemic activities of Albiglutide.
Eslicarbazepine Eslicarbazepine Eslicarbazepine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Belinostat Injection Belinostat Injection The metabolism of Belinostat can be decreased when combined with Amitriptyline.
Testosterone Injection Testosterone Injection The metabolism of Testosterone can be decreased when combined with Amitriptyline.
Oritavancin Injection Oritavancin Injection The metabolism of Amitriptyline can be decreased when combined with Oritavancin.
Empagliflozin Empagliflozin Amitriptyline may decrease the hypoglycemic activities of Empagliflozin.
Hydrocodone Hydrocodone Hydrocodone may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Suvorexant Suvorexant Amitriptyline may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Dulaglutide Injection Dulaglutide Injection Amitriptyline may decrease the hypoglycemic activities of Dulaglutide.
Edoxaban Edoxaban Amitriptyline may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The metabolism of Amitriptyline can be decreased when combined with Peginterferon beta-1a.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Amitriptyline.
Methamphetamine Methamphetamine Metamfetamine may decrease the sedative and stimulatory activities of Amitriptyline.
Tasimelteon Tasimelteon Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Riociguat Riociguat The metabolism of Riociguat can be decreased when combined with Amitriptyline.
Pirfenidone Pirfenidone The metabolism of Pirfenidone can be decreased when combined with Amitriptyline.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Amitriptyline.
Secukinumab Injection Secukinumab Injection The metabolism of Amitriptyline can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection Amitriptyline may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Risperidone.
Insulin Human Inhalation Insulin Human Inhalation The metabolism of Amitriptyline can be increased when combined with Insulin human.
Lenvatinib Lenvatinib The metabolism of Amitriptyline can be decreased when combined with Lenvatinib.
Naloxegol Naloxegol The metabolism of Amitriptyline can be decreased when combined with Naloxegol.
Panobinostat Panobinostat The metabolism of Amitriptyline can be decreased when combined with Panobinostat.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Amitriptyline.
Ivabradine Ivabradine Ivabradine may increase the QTc-prolonging activities of Amitriptyline.
Amiloride Amiloride Amiloride may increase the excretion rate of Amitriptyline which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan Macitentan Amitriptyline may decrease the excretion rate of Macitentan which could result in a higher serum level.
Flibanserin Flibanserin Flibanserin may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Rolapitant Rolapitant The metabolism of Amitriptyline can be decreased when combined with Rolapitant.
Daclatasvir Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Amitriptyline.
Brexpiprazole Brexpiprazole Brexpiprazole may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Amitriptyline.
Ziprasidone Injection Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Ziprasidone is combined with Amitriptyline.
Cariprazine Cariprazine The metabolism of Amitriptyline can be decreased when combined with Cariprazine.
Penicillin G Procaine Injection Penicillin G Procaine Injection Amitriptyline may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline Eluxadoline The risk or severity of constipation can be increased when Amitriptyline is combined with Eluxadoline.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The metabolism of Amitriptyline can be increased when combined with Insulin degludec.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Amitriptyline.
Osimertinib Osimertinib The serum concentration of Amitriptyline can be decreased when it is combined with Osimertinib.
Ixazomib Ixazomib Amitriptyline may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Rifapentine Rifapentine The metabolism of Amitriptyline can be increased when combined with Rifapentine.
Lesinurad Lesinurad Amitriptyline may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection The metabolism of Amitriptyline can be increased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection Amitriptyline may increase the central nervous system depressant (CNS depressant) activities of Brivaracetam.
Cobicistat Cobicistat The metabolism of Amitriptyline can be decreased when combined with Cobicistat.
Midodrine Midodrine Midodrine may increase the vasopressor activities of Amitriptyline.
Selexipag Selexipag The metabolism of Selexipag can be decreased when combined with Amitriptyline.
Pimavanserin Pimavanserin The risk or severity of adverse effects can be increased when Amitriptyline is combined with Pimavanserin.
Obeticholic Acid Obeticholic Acid The metabolism of Amitriptyline can be decreased when combined with Obeticholic acid.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Amitriptyline can be decreased when combined with Diphenhydramine.
Furosemide Injection Furosemide Injection Amitriptyline may decrease the excretion rate of Furosemide which could result in a higher serum level.
Rucaparib Rucaparib The metabolism of Amitriptyline can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection Amitriptyline may decrease the hypoglycemic activities of Lixisenatide.
Ribociclib Ribociclib The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Ribociclib.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Amitriptyline.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Amitriptyline can be decreased when combined with Doxepin.
Plecanatide Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Amitriptyline.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Amitriptyline.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Amitriptyline.
Deflazacort Deflazacort The metabolism of Amitriptyline can be increased when combined with Deflazacort.
Safinamide Safinamide The metabolism of Amitriptyline can be decreased when combined with Safinamide.
Naldemedine Naldemedine Amitriptyline may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Midostaurin Midostaurin The metabolism of Amitriptyline can be decreased when combined with Midostaurin.
Enasidenib Enasidenib The metabolism of Amitriptyline can be decreased when combined with Enasidenib.
Benznidazole Benznidazole Amitriptyline may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Amitriptyline.
Delafloxacin Delafloxacin Delafloxacin may increase the QTc-prolonging activities of Amitriptyline.
Acalabrutinib Acalabrutinib The metabolism of Amitriptyline can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Amitriptyline can be decreased when combined with Letermovir.
Semaglutide Injection Semaglutide Injection Amitriptyline may decrease the hypoglycemic activities of Semaglutide.
Tetrabenazine Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Amitriptyline.
Ertugliflozin Ertugliflozin Amitriptyline may decrease the hypoglycemic activities of Ertugliflozin.
Buprenorphine Injection Buprenorphine Injection The metabolism of Amitriptyline can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The serum concentration of Amitriptyline can be increased when it is combined with Apalutamide.
Fostamatinib Fostamatinib The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Amitriptyline.
Avatrombopag Avatrombopag The metabolism of Amitriptyline can be increased when combined with Avatrombopag.
Baricitinib Baricitinib Amitriptyline may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine The therapeutic efficacy of Amitriptyline can be increased when used in combination with Lofexidine.
Plazomicin Injection Plazomicin Injection Amitriptyline may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat Eliglustat The metabolism of Amitriptyline can be decreased when combined with Eliglustat.
Encorafenib Encorafenib The metabolism of Encorafenib can be decreased when combined with Amitriptyline.
Binimetinib Binimetinib The metabolism of Binimetinib can be decreased when combined with Amitriptyline.
Ivosidenib Ivosidenib The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Ivosidenib.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Amitriptyline.
Doravirine Doravirine The metabolism of Doravirine can be decreased when combined with Amitriptyline.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Amitriptyline.
Cannabidiol Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Amitriptyline.
Dacomitinib Dacomitinib The metabolism of Amitriptyline can be decreased when combined with Dacomitinib.
Stiripentol Stiripentol The metabolism of Amitriptyline can be decreased when combined with Stiripentol.
Gilteritinib Gilteritinib The therapeutic efficacy of Amitriptyline can be decreased when used in combination with Gilteritinib.
Glasdegib Glasdegib The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Glasdegib.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Amitriptyline.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Amitriptyline.
Rifamycin Rifamycin The metabolism of Amitriptyline can be decreased when combined with Rifamycin.
Prucalopride Prucalopride Amitriptyline may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Magnesium Citrate Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Amitriptyline.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Amitriptyline can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Amitriptyline.
Acyclovir Ophthalmic Acyclovir Ophthalmic The metabolism of Acyclovir can be decreased when combined with Amitriptyline.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Amitriptyline.
Esomeprazole Injection Esomeprazole Injection The metabolism of Amitriptyline can be decreased when combined with Esomeprazole.
Alpelisib Alpelisib The serum concentration of Amitriptyline can be decreased when it is combined with Alpelisib.
Brexanolone Injection Brexanolone Injection Brexanolone may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Solriamfetol Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Amitriptyline.
Darolutamide Darolutamide The metabolism of Darolutamide can be decreased when combined with Amitriptyline.
Triclabendazole Triclabendazole The metabolism of Amitriptyline can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Entrectinib.
Pexidartinib Pexidartinib The metabolism of Amitriptyline can be decreased when combined with Pexidartinib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Amitriptyline.
Pitolisant Pitolisant The therapeutic efficacy of Pitolisant can be decreased when used in combination with Amitriptyline.
Fedratinib Fedratinib The metabolism of Fedratinib can be decreased when combined with Amitriptyline.
Lefamulin Lefamulin Lefamulin may increase the QTc-prolonging activities of Amitriptyline.
Phenytoin Injection Phenytoin Injection The metabolism of Amitriptyline can be decreased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Amitriptyline can be decreased when combined with Fosphenytoin.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Amitriptyline.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Amitriptyline.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Amitriptyline.
Lumateperone Lumateperone The serum concentration of Amitriptyline can be increased when it is combined with Lumateperone.
Lasmiditan Lasmiditan The risk or severity of serotonin syndrome can be increased when Amitriptyline is combined with Lasmiditan.
Cenobamate Cenobamate The serum concentration of Amitriptyline can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod The metabolism of Ozanimod can be decreased when combined with Amitriptyline.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Amitriptyline.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Amitriptyline.
Sacituzumab govitecan-hziy Injection Sacituzumab govitecan-hziy Injection The serum concentration of Sacituzumab govitecan can be increased when it is combined with Amitriptyline.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be increased when it is combined with Amitriptyline.
Capmatinib Capmatinib The metabolism of Amitriptyline can be decreased when combined with Capmatinib.
Lemborexant Lemborexant The serum concentration of Amitriptyline can be decreased when it is combined with Lemborexant.
Daratumumab and Hyaluronidase-fihj Injection Daratumumab and Hyaluronidase-fihj Injection The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Amitriptyline.
Fenfluramine Fenfluramine The metabolism of Amitriptyline can be decreased when combined with Fenfluramine.
Fostemsavir Fostemsavir The risk or severity of QTc prolongation can be increased when Fostemsavir is combined with Amitriptyline.
Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf Injection Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf Injection The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Amitriptyline.
Octreotide Octreotide The risk or severity of QTc prolongation can be increased when Octreotide is combined with Amitriptyline.
Pralsetinib Pralsetinib The metabolism of Amitriptyline can be decreased when combined with Pralsetinib.
Opicapone Opicapone The metabolism of Amitriptyline can be decreased when combined with Opicapone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Amitriptyline can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Amitriptyline is combined with Naxitamab.
Relugolix Relugolix The risk or severity of QTc prolongation can be increased when Relugolix is combined with Amitriptyline.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Amitriptyline which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine Viloxazine Viloxazine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Theophylline Theophylline The metabolism of Amitriptyline can be decreased when combined with Theophylline.
Fenoprofen Fenoprofen Amitriptyline may decrease the excretion rate of Fenoprofen which could result in a higher serum level.
Indomethacin Indomethacin Amitriptyline may decrease the excretion rate of Indomethacin which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid The metabolism of Mefenamic acid can be decreased when combined with Amitriptyline.
Naproxen Naproxen The metabolism of Naproxen can be decreased when combined with Amitriptyline.
Tolmetin Tolmetin Amitriptyline may decrease the excretion rate of Tolmetin which could result in a higher serum level.
Sulindac Sulindac Amitriptyline may decrease the excretion rate of Sulindac which could result in a higher serum level.
Trazodone Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Amitriptyline.
Isotretinoin Isotretinoin Amitriptyline may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Amitriptyline may decrease the excretion rate of Sucralfate which could result in a higher serum level.
Hydroxyurea Hydroxyurea The metabolism of Amitriptyline can be decreased when combined with Hydroxyurea.
Floxuridine Floxuridine The metabolism of Amitriptyline can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital The metabolism of Amitriptyline can be decreased when combined with Phenobarbital.
Metaxalone Metaxalone Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Methotrexate Injection Methotrexate Injection Methotrexate may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Levorphanol Levorphanol The risk or severity of adverse effects can be increased when Amitriptyline is combined with Levorphanol.
Primidone Primidone The metabolism of Amitriptyline can be increased when combined with Primidone.
Methsuximide Methsuximide Methsuximide may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Diethylpropion Diethylpropion Diethylpropion may decrease the sedative and stimulatory activities of Amitriptyline.
Chlorpromazine Chlorpromazine Amitriptyline may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Chlorpromazine.
Diazepam Diazepam Amitriptyline may increase the central nervous system depressant (CNS depressant) activities of Diazepam.
Oxazepam Oxazepam Oxazepam may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Flurazepam Flurazepam Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Clorazepate Clorazepate Clorazepic acid may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Lorazepam Lorazepam Lorazepam may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Phenoxybenzamine Phenoxybenzamine Amitriptyline may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Phenoxybenzamine.
Carmustine Carmustine The metabolism of Amitriptyline can be decreased when combined with Carmustine.
Amantadine Amantadine The risk or severity of serotonin syndrome can be increased when Amitriptyline is combined with Amantadine.
Codeine Codeine The risk or severity of adverse effects can be increased when Amitriptyline is combined with Codeine.
Meprobamate Meprobamate The risk or severity of adverse effects can be increased when Amitriptyline is combined with Meprobamate.
Bromocriptine Bromocriptine Bromocriptine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Amitriptyline.
Metaproterenol Metaproterenol The risk or severity of hypertension can be increased when Amitriptyline is combined with Orciprenaline.
Tranylcypromine Tranylcypromine The metabolism of Amitriptyline can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Amitriptyline can be decreased when combined with Phenelzine.
Procarbazine Procarbazine Procarbazine may increase the serotonergic activities of Amitriptyline.
Ergoloid Mesylates Ergoloid Mesylates Ergoloid mesylate may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Tetracycline Tetracycline Amitriptyline may decrease the excretion rate of Tetracycline which could result in a higher serum level.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Prochlorperazine Prochlorperazine The serum concentration of Amitriptyline can be increased when it is combined with Prochlorperazine.
Thioridazine Thioridazine The metabolism of Amitriptyline can be decreased when combined with Thioridazine.
Trifluoperazine Trifluoperazine Trifluoperazine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Amitriptyline.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Dapsone Dapsone The metabolism of Amitriptyline can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The metabolism of Amitriptyline can be decreased when combined with Sulfadiazine.
Oxycodone Oxycodone The risk or severity of adverse effects can be increased when Oxycodone is combined with Amitriptyline.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Amitriptyline.
Oxybutynin Oxybutynin The metabolism of Amitriptyline can be decreased when combined with Oxybutynin.
Benztropine Benztropine The metabolism of Benzatropine can be decreased when combined with Amitriptyline.
Maprotiline Maprotiline The metabolism of Maprotiline can be decreased when combined with Amitriptyline.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Amitriptyline.
Trihexyphenidyl Trihexyphenidyl Amitriptyline may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine Orphenadrine The metabolism of Amitriptyline can be decreased when combined with Orphenadrine.
Azathioprine Azathioprine The metabolism of Azathioprine can be decreased when combined with Amitriptyline.
Fluphenazine Fluphenazine The metabolism of Amitriptyline can be decreased when combined with Fluphenazine.
Phentermine Phentermine Phentermine may decrease the sedative and stimulatory activities of Amitriptyline.
Methylphenidate Methylphenidate The risk or severity of adverse effects can be increased when Amitriptyline is combined with Methylphenidate.
Amoxapine Amoxapine Amitriptyline may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Amoxapine.
Sulfasalazine Sulfasalazine Amitriptyline may decrease the excretion rate of Sulfasalazine which could result in a higher serum level.
Hydrocortisone Hydrocortisone The metabolism of Amitriptyline can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Amitriptyline can be decreased when combined with Doxorubicin.
Mechlorethamine Mechlorethamine The therapeutic efficacy of Amitriptyline can be decreased when used in combination with Mechlorethamine.
Pyridostigmine Pyridostigmine The therapeutic efficacy of Amitriptyline can be decreased when used in combination with Pyridostigmine.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Amitriptyline.
Molindone Molindone The risk or severity of adverse effects can be increased when Amitriptyline is combined with Molindone.
Methyldopa Methyldopa The therapeutic efficacy of Methyldopa can be decreased when used in combination with Amitriptyline.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Amitriptyline.
Prazosin Prazosin Amitriptyline may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Prazosin.
Hydralazine Hydralazine Amitriptyline may decrease the excretion rate of Hydralazine which could result in a higher serum level.
Cimetidine Cimetidine The metabolism of Amitriptyline can be decreased when combined with Cimetidine.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Warfarin Warfarin The metabolism of Amitriptyline can be decreased when combined with Warfarin.
Clonazepam Clonazepam Clonazepam may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Loperamide Loperamide The metabolism of Loperamide can be decreased when combined with Amitriptyline.
Promethazine Promethazine The metabolism of Amitriptyline can be decreased when combined with Promethazine.
Meclofenamate Meclofenamate Amitriptyline may decrease the excretion rate of Meclofenamic acid which could result in a higher serum level.
Daunorubicin Daunorubicin The metabolism of Amitriptyline can be increased when combined with Daunorubicin.
Nitrofurantoin Nitrofurantoin Amitriptyline may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Amitriptyline can be increased when combined with Griseofulvin.
Digoxin Digoxin Amitriptyline may decrease the excretion rate of Digoxin which could result in a higher serum level.
Loxapine Loxapine Loxapine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Chloroquine Chloroquine The metabolism of Amitriptyline can be decreased when combined with Chloroquine.
Quinine Quinine The metabolism of Amitriptyline can be decreased when combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of QTc prolongation can be increased when Ethosuximide is combined with Amitriptyline.
Triamterene Triamterene The metabolism of Triamterene can be decreased when combined with Amitriptyline.
Lactulose Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Amitriptyline.
Sulfinpyrazone Sulfinpyrazone The metabolism of Amitriptyline can be decreased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide Amitriptyline may increase the excretion rate of Chlorothiazide which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone Chlorthalidone Amitriptyline may increase the excretion rate of Chlorthalidone which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone Metolazone Amitriptyline may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide Isosorbide may increase the excretion rate of Amitriptyline which could result in a lower serum level and potentially a reduction in efficacy.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Amitriptyline.
Secobarbital Secobarbital The metabolism of Amitriptyline can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Amitriptyline can be decreased when combined with Desipramine.
Imipramine Imipramine The metabolism of Amitriptyline can be decreased when combined with Imipramine.
Probenecid Probenecid The metabolism of Amitriptyline can be decreased when combined with Probenecid.
Quinidine Quinidine The metabolism of Amitriptyline can be decreased when combined with Quinidine.
Procainamide Procainamide The metabolism of Procainamide can be decreased when combined with Amitriptyline.
Isoniazid Isoniazid The metabolism of Amitriptyline can be decreased when combined with Isoniazid.
Pyrazinamide Pyrazinamide Amitriptyline may decrease the excretion rate of Pyrazinamide which could result in a higher serum level.
Rifampin Rifampin The metabolism of Amitriptyline can be increased when combined with Rifampicin.
Disopyramide Disopyramide The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Disopyramide.
Valproic Acid Valproic Acid The metabolism of Amitriptyline can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Amitriptyline can be decreased when combined with Tamoxifen.
Butabarbital Butabarbital Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Levothyroxine Levothyroxine The risk or severity of Cardiac Arrhythmia and CNS stimulation can be increased when Levothyroxine is combined with Amitriptyline.
Liothyronine Liothyronine The risk or severity of Cardiac Arrhythmia can be increased when Liothyronine is combined with Amitriptyline.
Methimazole Methimazole The metabolism of Amitriptyline can be decreased when combined with Methimazole.
Propylthiouracil Propylthiouracil The risk or severity of Cardiac Arrhythmia can be increased when Propylthiouracil is combined with Amitriptyline.
Chlorpropamide Chlorpropamide Amitriptyline may decrease the hypoglycemic activities of Chlorpropamide.
Glucagon Injection Glucagon Injection Amitriptyline may increase the gastrointestinal motility reducing activities of Glucagon.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Amitriptyline.
Tolazamide Tolazamide Amitriptyline may decrease the hypoglycemic activities of Tolazamide.
Dextromethorphan Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Amitriptyline.
Cyclobenzaprine Cyclobenzaprine The risk or severity of CNS depression can be increased when Amitriptyline is combined with Cyclobenzaprine.
Niacin Niacin The metabolism of Amitriptyline can be decreased when combined with Niacin.
Baclofen Baclofen The risk or severity of CNS depression and hypotonia can be increased when Baclofen is combined with Amitriptyline.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Cyproheptadine Cyproheptadine The risk or severity of QTc prolongation can be increased when Cyproheptadine is combined with Amitriptyline.
Clemastine Clemastine The metabolism of Amitriptyline can be decreased when combined with Clemastine.
Chlorpheniramine Chlorpheniramine The metabolism of Amitriptyline can be decreased when combined with Chlorpheniramine.
Brompheniramine Brompheniramine Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Meclizine Meclizine The metabolism of Amitriptyline can be decreased when combined with Meclizine.
Ethambutol Ethambutol Amitriptyline may decrease the excretion rate of Ethambutol which could result in a higher serum level.
Methyclothiazide Methyclothiazide Amitriptyline may increase the excretion rate of Methyclothiazide which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide Hydrochlorothiazide Amitriptyline may decrease the excretion rate of Hydrochlorothiazide which could result in a higher serum level.
Dantrolene Dantrolene Dantrolene may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Chlorzoxazone Chlorzoxazone The metabolism of Amitriptyline can be decreased when combined with Chlorzoxazone.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Amitriptyline.
Methocarbamol Methocarbamol Methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Disulfiram Disulfiram The risk or severity of adverse effects can be increased when Disulfiram is combined with Amitriptyline.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Amitriptyline can be decreased when combined with Propranolol.
Minoxidil Minoxidil The metabolism of Minoxidil can be decreased when combined with Amitriptyline.
Pseudoephedrine Pseudoephedrine Pseudoephedrine may decrease the sedative and stimulatory activities of Amitriptyline.
Nortriptyline Nortriptyline The metabolism of Amitriptyline can be decreased when combined with Nortriptyline.
Spironolactone Spironolactone The metabolism of Amitriptyline can be decreased when combined with Spironolactone.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Phytonadione Phytonadione Amitriptyline may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Nadolol Nadolol The metabolism of Nadolol can be decreased when combined with Amitriptyline.
Butorphanol Injection Butorphanol Injection The risk or severity of adverse effects can be increased when Amitriptyline is combined with Butorphanol.
Nalbuphine Injection Nalbuphine Injection The risk or severity of adverse effects can be increased when Amitriptyline is combined with Nalbuphine.
Allopurinol Allopurinol Amitriptyline may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Oxytocin Injection Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Amitriptyline.
Trimethobenzamide Trimethobenzamide Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Flavoxate Flavoxate Amitriptyline may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Papaverine Papaverine The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Papaverine.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Amitriptyline.
Colchicine Colchicine The metabolism of Amitriptyline can be decreased when combined with Colchicine.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Dacarbazine Dacarbazine The metabolism of Dacarbazine can be decreased when combined with Amitriptyline.
Acetazolamide Acetazolamide Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection The risk or severity of Cardiac Arrhythmia can be increased when Salmon calcitonin is combined with Amitriptyline.
Ketoconazole Ketoconazole The metabolism of Amitriptyline can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel Pyrantel may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Thiotepa Injection Thiotepa Injection The metabolism of Amitriptyline can be decreased when combined with Thiotepa.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be decreased when combined with Amitriptyline.
Captopril Captopril Amitriptyline may decrease the antihypertensive activities of Captopril.
Dipyridamole Dipyridamole The risk or severity of hypotension, dyspepsia, and headache can be increased when Dipyridamole is combined with Amitriptyline.
Isoxsuprine Isoxsuprine The risk or severity of hypertension can be increased when Amitriptyline is combined with Isoxsuprine.
Vinblastine Vinblastine The metabolism of Amitriptyline can be decreased when combined with Vinblastine.
Ethacrynic Acid Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Metoprolol Metoprolol The metabolism of Amitriptyline can be decreased when combined with Metoprolol.
Hydroxyzine Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Amitriptyline.
Thiothixene Thiothixene The metabolism of Amitriptyline can be decreased when combined with Thiothixene.
Aspirin Aspirin Amitriptyline may decrease the excretion rate of Acetylsalicylic acid which could result in a higher serum level.
Salsalate Salsalate Amitriptyline may decrease the excretion rate of Salsalate which could result in a higher serum level.
Alprazolam Alprazolam Amitriptyline may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.
Temazepam Temazepam Temazepam may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Triazolam Triazolam Triazolam may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Dicyclomine Dicyclomine Amitriptyline may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine Hyoscyamine The risk or severity of QTc prolongation can be increased when Hyoscyamine is combined with Amitriptyline.
Propantheline Propantheline Amitriptyline may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Trimethoprim Trimethoprim The metabolism of Trimethoprim can be decreased when combined with Amitriptyline.
Diltiazem Diltiazem The metabolism of Diltiazem can be decreased when combined with Amitriptyline.
Nifedipine Nifedipine The metabolism of Amitriptyline can be decreased when combined with Nifedipine.
Timolol Timolol The metabolism of Timolol can be decreased when combined with Amitriptyline.
Verapamil Verapamil The metabolism of Amitriptyline can be decreased when combined with Verapamil.
Atenolol Atenolol The metabolism of Atenolol can be decreased when combined with Amitriptyline.
Pindolol Pindolol The metabolism of Amitriptyline can be decreased when combined with Pindolol.
Cisplatin Injection Cisplatin Injection Amitriptyline may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal Amitriptyline may decrease the excretion rate of Diflunisal which could result in a higher serum level.
Piroxicam Piroxicam The metabolism of Piroxicam can be decreased when combined with Amitriptyline.
Bumetanide Bumetanide Bumetanide may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Streptozocin Streptozocin The metabolism of Amitriptyline can be increased when combined with Streptozocin.
Etoposide Etoposide The metabolism of Etoposide can be decreased when combined with Amitriptyline.
Glyburide Glyburide The metabolism of Amitriptyline can be decreased when combined with Glyburide.
Glipizide Glipizide Amitriptyline may decrease the hypoglycemic activities of Glipizide.
Indapamide Indapamide Amitriptyline may increase the excretion rate of Indapamide which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin Amoxicillin Amitriptyline may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Nafcillin Injection Nafcillin Injection The metabolism of Amitriptyline can be increased when combined with Nafcillin.
Oxacillin Injection Oxacillin Injection Amitriptyline may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline Pentoxifylline The metabolism of Pentoxifylline can be decreased when combined with Amitriptyline.
Pentamidine Injection Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Amitriptyline.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Labetalol Labetalol The metabolism of Amitriptyline can be decreased when combined with Labetalol.
Auranofin Auranofin Amitriptyline may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Amitriptyline.
Gemfibrozil Gemfibrozil The metabolism of Amitriptyline can be decreased when combined with Gemfibrozil.
Guanabenz Guanabenz The risk or severity of hypertension can be increased when Amitriptyline is combined with Guanabenz.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Amitriptyline.
Enalapril Enalapril Amitriptyline may decrease the antihypertensive activities of Enalapril.
Flurbiprofen Flurbiprofen Amitriptyline may decrease the excretion rate of Flurbiprofen which could result in a higher serum level.
Amiodarone Amiodarone The metabolism of Amitriptyline can be decreased when combined with Amiodarone.
Aztreonam Injection Aztreonam Injection Amitriptyline may decrease the excretion rate of Aztreonam which could result in a higher serum level.
Buspirone Buspirone The metabolism of Buspirone can be decreased when combined with Amitriptyline.
Lovastatin Lovastatin The metabolism of Amitriptyline can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin Ciprofloxacin may increase the QTc-prolonging activities of Amitriptyline.
Mesalamine Mesalamine Mesalazine may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Diclofenac Diclofenac The metabolism of Diclofenac can be decreased when combined with Amitriptyline.
Fluoxetine Fluoxetine The metabolism of Amitriptyline can be decreased when combined with Fluoxetine.
Nimodipine Nimodipine The risk or severity of hypotension can be increased when Amitriptyline is combined with Nimodipine.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The metabolism of Amitriptyline can be decreased when combined with Interferon alfa-2b.
Clozapine Clozapine The metabolism of Amitriptyline can be decreased when combined with Clozapine.
Estazolam Estazolam Estazolam may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Amitriptyline.
Ofloxacin Ofloxacin Ofloxacin may increase the QTc-prolonging activities of Amitriptyline.
Didanosine Didanosine Amitriptyline may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Amitriptyline may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Clarithromycin Clarithromycin The metabolism of Amitriptyline can be decreased when combined with Clarithromycin.
Benazepril Benazepril Amitriptyline may decrease the antihypertensive activities of Benazepril.
Etodolac Etodolac Amitriptyline may decrease the excretion rate of Etodolac which could result in a higher serum level.
Felodipine Felodipine The metabolism of Amitriptyline can be decreased when combined with Felodipine.
Fosinopril Fosinopril Amitriptyline may decrease the excretion rate of Fosinopril which could result in a higher serum level.
Nabumetone Nabumetone The metabolism of Nabumetone can be decreased when combined with Amitriptyline.
Quinapril Quinapril Amitriptyline may decrease the antihypertensive activities of Quinapril.
Ramipril Ramipril Amitriptyline may decrease the antihypertensive activities of Ramipril.
Simvastatin Simvastatin The metabolism of Amitriptyline can be decreased when combined with Simvastatin.
Amlodipine Amlodipine The risk or severity of hypotension can be increased when Amitriptyline is combined with Amlodipine.
Teniposide Injection Teniposide Injection The metabolism of Amitriptyline can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Amitriptyline can be decreased when combined with Itraconazole.
Lisinopril Lisinopril Amitriptyline may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Oxaprozin Oxaprozin Amitriptyline may decrease the excretion rate of Oxaprozin which could result in a higher serum level.
Atovaquone Atovaquone The metabolism of Amitriptyline can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Amitriptyline can be increased when combined with Rifabutin.
Sotalol Sotalol The metabolism of Sotalol can be decreased when combined with Amitriptyline.
Bisoprolol Bisoprolol Amitriptyline may increase the orthostatic hypotensive activities of Bisoprolol.
Zolpidem Zolpidem Amitriptyline may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin Doxazosin Amitriptyline may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxazosin.
Terazosin Terazosin Amitriptyline may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Terazosin.
Isradipine Isradipine The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Isradipine.
Omeprazole Omeprazole The metabolism of Amitriptyline can be decreased when combined with Omeprazole.
Cisapride Cisapride Amitriptyline may increase the arrhythmogenic activities of Cisapride.
Gabapentin Gabapentin The risk or severity of adverse effects can be increased when Amitriptyline is combined with Gabapentin.
Fluvastatin Fluvastatin The metabolism of Amitriptyline can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The metabolism of Amitriptyline can be decreased when combined with Venlafaxine.
Nizatidine Nizatidine The therapeutic efficacy of Amitriptyline can be decreased when used in combination with Nizatidine.
Stavudine Stavudine Amitriptyline may increase the neurotoxic activities of Stavudine.
Fluvoxamine Fluvoxamine The metabolism of Amitriptyline can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Amitriptyline can be decreased when combined with Nefazodone.
Lamotrigine Lamotrigine The metabolism of Amitriptyline can be increased when combined with Lamotrigine.
Losartan Losartan The metabolism of Losartan can be decreased when combined with Amitriptyline.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Tramadol Tramadol The risk or severity of serotonin syndrome can be increased when Amitriptyline is combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The metabolism of Amitriptyline can be decreased when combined with Vinorelbine.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Moexipril Moexipril The risk or severity of QTc prolongation can be increased when Moexipril is combined with Amitriptyline.
Lansoprazole Lansoprazole The metabolism of Amitriptyline can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Amitriptyline.
Nicardipine Nicardipine The metabolism of Amitriptyline can be decreased when combined with Nicardipine.
Bupropion Bupropion The risk or severity of seizure can be increased when Bupropion is combined with Amitriptyline.
Ticlopidine Ticlopidine The metabolism of Amitriptyline can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Amitriptyline can be decreased when combined with Saquinavir.
Metformin Metformin Amitriptyline may decrease the hypoglycemic activities of Metformin.
Nisoldipine Nisoldipine The risk or severity of hypotension can be increased when Amitriptyline is combined with Nisoldipine.
Lamivudine Lamivudine Amitriptyline may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole Riluzole may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Acarbose Acarbose Amitriptyline may decrease the hypoglycemic activities of Acarbose.
Glimepiride Glimepiride Amitriptyline may decrease the hypoglycemic activities of Glimepiride.
Anastrozole Anastrozole The metabolism of Anastrozole can be decreased when combined with Amitriptyline.
Gemcitabine Injection Gemcitabine Injection Amitriptyline may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Indinavir Indinavir The metabolism of Amitriptyline can be decreased when combined with Indinavir.
Ritonavir Ritonavir The metabolism of Amitriptyline can be decreased when combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Amitriptyline.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Meropenem Injection Meropenem Injection Amitriptyline may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine Clomipramine The metabolism of Amitriptyline can be decreased when combined with Clomipramine.
Zafirlukast Zafirlukast The metabolism of Amitriptyline can be decreased when combined with Zafirlukast.
Fosfomycin Fosfomycin Amitriptyline may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine Mirtazapine Amitriptyline may increase the serotonergic activities of Mirtazapine.
Trandolapril Trandolapril Amitriptyline may decrease the antihypertensive activities of Trandolapril.
Topiramate Topiramate The risk or severity of hyperthermia and oligohydrosis can be increased when Amitriptyline is combined with Topiramate.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Amitriptyline.
Valsartan Valsartan The metabolism of Amitriptyline can be decreased when combined with Valsartan.
Insulin Lispro Injection Insulin Lispro Injection The metabolism of Amitriptyline can be increased when combined with Insulin lispro.
Pramipexole Pramipexole Amitriptyline may increase the sedative activities of Pramipexole.
Donepezil Donepezil The therapeutic efficacy of Amitriptyline can be decreased when used in combination with Donepezil.
Nelfinavir Nelfinavir The metabolism of Amitriptyline can be decreased when combined with Nelfinavir.
Azithromycin Azithromycin The risk or severity of QTc prolongation can be increased when Azithromycin is combined with Amitriptyline.
Loratadine Loratadine The metabolism of Amitriptyline can be decreased when combined with Loratadine.
Carvedilol Carvedilol Amitriptyline may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Carvedilol.
Nilutamide Nilutamide The metabolism of Amitriptyline can be decreased when combined with Nilutamide.
Flutamide Flutamide The metabolism of Flutamide can be decreased when combined with Amitriptyline.
Selegiline Selegiline The metabolism of Amitriptyline can be decreased when combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Amitriptyline can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Amitriptyline can be decreased when combined with Sertraline.
Propafenone Propafenone The metabolism of Amitriptyline can be decreased when combined with Propafenone.
Letrozole Letrozole The metabolism of Amitriptyline can be decreased when combined with Letrozole.
Raloxifene Raloxifene The metabolism of Amitriptyline can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Irbesartan can be decreased when combined with Amitriptyline.
Tamsulosin Tamsulosin Amitriptyline may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Tamsulosin.
Ropinirole Ropinirole Amitriptyline may increase the sedative activities of Ropinirole.
Finasteride Finasteride The metabolism of Finasteride can be decreased when combined with Amitriptyline.
Quetiapine Quetiapine Amitriptyline may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Quetiapine.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Cetirizine Cetirizine Cetirizine may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Paroxetine Paroxetine The metabolism of Amitriptyline can be decreased when combined with Paroxetine.
Tolcapone Tolcapone The metabolism of Amitriptyline can be decreased when combined with Tolcapone.
Citalopram Citalopram The metabolism of Amitriptyline can be decreased when combined with Citalopram.
Capecitabine Capecitabine The metabolism of Amitriptyline can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Efavirenz can be decreased when combined with Amitriptyline.
Abacavir Abacavir The metabolism of Abacavir can be decreased when combined with Amitriptyline.
Sildenafil Sildenafil The metabolism of Amitriptyline can be decreased when combined with Sildenafil.
Pioglitazone Pioglitazone The metabolism of Amitriptyline can be decreased when combined with Pioglitazone.
Celecoxib Celecoxib The metabolism of Amitriptyline can be decreased when combined with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Amitriptyline can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Amitriptyline.
Thalidomide Thalidomide Amitriptyline may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Balsalazide Balsalazide Amitriptyline may decrease the excretion rate of Balsalazide which could result in a higher serum level.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Amitriptyline.
Galantamine Galantamine The metabolism of Galantamine can be decreased when combined with Amitriptyline.
Levetiracetam Levetiracetam Levetiracetam may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Rabeprazole Rabeprazole The metabolism of Amitriptyline can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Amitriptyline can be decreased when combined with Terbinafine.

* This branded product is no longer on the market. Generic alternatives may be available.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists