Medication interaction hub

What Supplements Interact with Morphine Sulfate?

Morphine Sulfate brand names: MS Contin, Kadian, Avinza, Morphabond, Arymo ER. Every interaction below applies to the brands too.

172 Interactions 8 Major 138 Moderate 26 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Morphine Sulfate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Morphine Sulfate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

With morphine sulfate (MS Contin, Kadian, Avinza), an opioid powerful enough to slow breathing on its own, this list warrants genuine respect. Of the 172 supplements and foods on file, 8 carry a major rating, and most of those pile extra sedation onto a drug that already sedates. Alcohol and kava lead that group; stacking sedating substances on an opioid can deepen drowsiness and, at the extreme, suppress breathing.

The rest works more quietly. St. John's wort can push morphine levels down by speeding it out of the body, and adsorbents like activated charcoal can keep an oral dose from being absorbed, so space those well apart from your medication. Most of the 138 moderate and 26 minor entries nudge how the body clears the drug or add a gentler layer of sleepiness. Learn the eight majors first; that is where the danger concentrates.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 138 Minor 26 No known interaction 1,280

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Morphine Sulfate: Top Interactions at a Glance

The Morphine Sulfate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 172 interacting ingredients — plus 1,280 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Morphine Sulfate Combinations Today

The Morphine Sulfate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Cannabis + Morphine Sulfatei

Theoretically, cannabis might have additive effects if used with other CNS depressants.

Read the full interaction Moderate Likelihood Possible Melatonin + Morphine Sulfatei

Theoretically, taking melatonin might increase the sedative effects of CNS depressants.

Read the full interaction Major Likelihood Probable Gamma-hydroxybutyrate (ghb) + Morphine Sulfatei

GHB may increase the risk of serious CNS and respiratory depression.

Read the full interaction Moderate Likelihood Possible Catnip + Morphine Sulfatei

Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Read the full interaction Moderate Likelihood Possible Lemongrass + Morphine Sulfatei

Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.

Read the full interaction Moderate Likelihood Possible Tree Turmeric + Morphine Sulfatei

Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Morphine Sulfate

All 1,452 ingredients in our database, ranked by severity — 172 with a Morphine Sulfate interaction on file and 1,280 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Morphine Sulfate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cannabis with Morphine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis might have additive effects if used with other CNS depressants.

Full Cannabis + Morphine Sulfate answer

Can you take Melatonin with Morphine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin might increase the sedative effects of CNS depressants.

Full Melatonin + Morphine Sulfate answer

Can you take Gamma-hydroxybutyrate (ghb) with Morphine Sulfate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. GHB may increase the risk of serious CNS and respiratory depression.

Full Gamma-hydroxybutyrate (ghb) + Morphine Sulfate answer

Can you take Catnip with Morphine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Full Catnip + Morphine Sulfate answer

Can you take Lemongrass with Morphine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.

Full Lemongrass + Morphine Sulfate answer

Can you take Shiitake Mushroom with Morphine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Full Shiitake Mushroom + Morphine Sulfate answer

Can you take Skullcap with Morphine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, skullcap can have additive effects when used with other CNS depressants.

Full Skullcap + Morphine Sulfate answer

Can you take Slippery Elm with Morphine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Morphine Sulfate answer

Can you take Spearmint with Morphine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, spearmint might alter the sedative effects of CNS depressants.

Full Spearmint + Morphine Sulfate answer

Can you take Strawberry with Morphine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that strawberry extract can inhibit p-glycoprotein efflux.

Full Strawberry + Morphine Sulfate answer

Can you take Sweet Orange with Morphine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.

Full Sweet Orange + Morphine Sulfate answer

Can you take Tarragon with Morphine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that tarragon essential oil can cause sedation and motor impairment when administered intraperitoneal...

Full Tarragon + Morphine Sulfate answer

Can you take Terminalia with Morphine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.

Full Terminalia + Morphine Sulfate answer

Can you take Theacrine with Morphine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, theacrine might alter the effects of CNS depressants.

Full Theacrine + Morphine Sulfate answer

Can you take Thuja with Morphine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja products can contains significant amounts of thujone, a neurotoxin.

Full Thuja + Morphine Sulfate answer

Can you take Tianeptine with Morphine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Tianeptine has sedative effects; high doses may have additive effects with other CNS depressants.

Full Tianeptine + Morphine Sulfate answer

Can you take Tinospora Cordifolia with Morphine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.

Full Tinospora Cordifolia + Morphine Sulfate answer

Can you take Tragacanth with Morphine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Morphine Sulfate answer

Can you take Tree Turmeric with Morphine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.

Full Tree Turmeric + Morphine Sulfate answer

Can you take Uva Ursi with Morphine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.

Full Uva Ursi + Morphine Sulfate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Morphine Sulfate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Morphine Sulfate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Morphine Sulfate sits in 8 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Morphine Sulfate through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Morphine Sulfate through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Morphine Sulfate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Morphine Sulfate through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Morphine Sulfate through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Morphine Sulfate through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Morphine Sulfate through this category.

Morphine 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Morphine Sulfate through this category.

About Morphine Sulfate

Morphine is an opioid pain medication used to relieve moderate to severe pain.

Generic name: Morphine Sulfate  ·  Brand names: MS Contin, Kadian, Avinza, Morphabond, Arymo ER.

See the full Morphine drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Morphine Sulfate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Morphine Sulfate.

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Pharmacist Counseling Corner

Morphine Sulfate & Supplements: Common Questions

What supplements interact with Morphine Sulfate?
More than you might expect — 172 in total, though they are far from equal: 8 are rated major, 138 moderate, and 26 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Beer, Wine, 1,4-butanediol.
Which Morphine Sulfate supplement interactions are the most serious?
Focus on the major group: Beer, Wine, 1,4-butanediol, Activated Charcoal and Gamma-hydroxybutyrate (ghb), among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Morphine Sulfate?
Usually yes — most people on Morphine Sulfate can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like MS Contin have the same supplement interactions as Morphine Sulfate?
Yes — MS Contin, Kadian, Avinza, Morphabond, Arymo ER all contain Morphine Sulfate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Morphine Sulfate and my other medications?
This page covers Morphine Sulfate against supplements and herbal ingredients. Checking Morphine Sulfate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Morphine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.