Herb & supplement monograph

California Poppy Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how California Poppy interacts with medications. The heart of this page is the interaction list — every drug California Poppy is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what California Poppy is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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California Poppy Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant California Poppy drug interaction appears low for most people, though anyone taking sedating medicines should be aware of one theoretical concern. None of the listed interactions are rated major, and every one of them traces back to a single concern about added drowsiness that comes from laboratory research rather than studies in people.

Interactions deserving the most attention

The one group that stands out is CNS depressants, meaning medicines that cause drowsiness, such as sedatives, sleep aids, and similar drugs. Lab research shows California poppy itself has calming, sedative effects, so in theory it could add to the drowsiness these medicines cause. This has not been confirmed in human studies, but extra sedation can matter for alertness and safety, so it is the most sensible thing to watch for.

What the rest of the list means

Although the number of listed medications is large, it does not mean each combination has been shown to cause harm. Nearly all of these entries reflect that single theoretical sedation concern applied across the many drugs with drowsy side effects. No well-documented human interactions have been reported with this plant.

Check your medications against California Poppy

Based on HelloPharmacist’s California Poppy interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with California Poppy

248 medications have a known interaction with California Poppy, graded by severity. Select any drug for the full evidence-based detail.

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AI summaries are generated from our California Poppy interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

AcepromazineAtravet

Moderate Cns Depressants