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Dietary supplement

California Poppy Ingredients & Drug Interactions

by Gaia Herbs

California Poppy label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking California Poppy against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

California Poppy is a dietary supplement by Gaia Herbs with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping (insomnia), mild aches and pains.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic California Poppy (Eschscholzia californica) whole plant extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against California Poppy by Gaia Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with California Poppy by Gaia Herbs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of California Poppy by Gaia Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: organic California Poppy whole plant extract. California poppy has been used traditionally as a mild relaxing herb.

The liquid form also contains alcohol and water as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see California Poppy's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: sleep support and calm relaxation.
  • We looked for evidence on: Anxiety, Insomnia, Restlessness, Nervous tension.
  • The closest evidence on file: California Poppy is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: California Poppy is rated "Insufficient Reliable Evidence To Rate" for Insomnia.

The evidence we hold doesn't establish that California poppy works reliably for anxiety, insomnia, or nocturnal enuresis (bedwetting). The data shows insufficient reliable evidence to rate it for any of these uses.

That doesn't mean it won't help you — just that the studies available don't prove it does.

The evidence, ingredient by ingredient California Poppy

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

California poppy is generally considered mild for short-term use, though human safety data are limited. In combination with other herbs (hawthorn and magnesium), some people have reported muscular stiffness, morning fatigue, and nausea — but it's unclear whether California poppy itself caused these or whether it was the combination.

The safety data aren't robust enough to recommend this supplement during pregnancy or while breastfeeding; talk with your doctor or pharmacist for personalized guidance if you're considering it at these times.

Side effects, ingredient by ingredient California Poppy

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — California Poppy.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this if you use CNS depressants — sedative medications, sleep aids, benzodiazepines, opioids, or other drugs that slow brain activity. California poppy's own sedative effects may amplify theirs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

California Poppy may appeal to you if you're interested in a traditional relaxing herb, but the evidence doesn't prove it works for anxiety, insomnia, or bedwetting. The main caution is if you take sedative medications — the combination could increase drowsiness.

Talk with your doctor or pharmacist before combining it with any prescription drugs, especially those that affect your mood, sleep, or alertness.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 22, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about California Poppy, straight from the product label.

Brand Gaia Herbs
Barcode (UPC) 751063302302
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Dec 22, 2019
DSLD ID 209511
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for California Poppy by Gaia Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.67 mL
Maximum serving Sizes:
1.33 mL
Servings per container
23
UPC/BARCODE
751063302302
IngredientAmount% DV
organic California Poppy (Eschscholzia californica) whole plant extract1.33 mL--

Other ingredients: Alcohol, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Enter ID# at meetyourherbs.com

gaiaherbs.com @gaiaherbs Facebook Instagram

Suggested/Recommended/Usage/Directions

Suggested Use Adults take 20-40 drops of extract in a small amount of water 3 times daily between meals. Shake well before use.

Precautions

Not for use during pregnancy or lactation. If you have a medical condition or take medications, please consult with your doctor before use.

Store away from children.

Use only as directed on label. Safety-sealed at neck of bottle.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Sleep support Traditionally for calm & relaxation

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

California Poppy by Gaia Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

California Poppy label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in California Poppy by Gaia Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.67 mL Dosage formLiquid Servings per container23 Amounts shown are per serving.

Organic California Poppy (Eschscholzia californica) whole plant extract

Interacts with
248 drugs
1.33 mL per serving

California poppy is a traditional herbal remedy used mainly for anxiety and sleep problems, often combined with other calming herbs. Human research is...

Organic California Poppy (Eschscholzia californica) whole plant extract monograph & interactions

Other (inactive) ingredients: Alcohol, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

California Poppy by Gaia Herbs Drug Interactions

Want to check YOUR meds against California Poppy?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

organic California Poppy (Eschscholzia californica) whole plant extract 248

Individual Drug Interactions

The ingredients in California Poppy interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in California Poppy interact with drugs. Each result below shows which ingredient is responsible. organic California Poppy (Eschscholzia californica) whole plant extract

Each ingredient & the kinds of drugs it affects

For each ingredient in California Poppy with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic California Poppy (Eschscholzia californica) whole plant extract1 drug type · 248 drugs

Cns Depressants

Theoretically, taking California poppy with drugs with sedative effects may increase the risk of sedative effects.
Laboratory research shows that California poppy has sedative effects.

Likelihood Possible Evidence D
organic California Poppy (Eschscholzia californica) whole plant extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for California Poppy, from the product label.

Gaia Herbs

See all Gaia Herbs products
Name
Gaia Herbs, Inc.
Street Address
101 Gaia Herbs Dr.
City
Brevard
State
NC
ZipCode
28712
Web Address
GaiaHerbs.com
Pharmacist Counseling Corner

California Poppy by Gaia Herbs: Common Questions

Does California Poppy by Gaia Herbs interact with any medications?
Yes. Based on its ingredients, California Poppy has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
California Poppy contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take California Poppy if I'm pregnant or breastfeeding?
There isn't enough safety data to recommend California poppy during pregnancy or while breastfeeding. Talk with your doctor or pharmacist about whether it's right for you in these situations — they can weigh the risks and benefits for your specific circumstances.
What side effects has California poppy caused?
We have limited adverse effect data. When used in a combination product with hawthorn and magnesium, some people reported muscular stiffness, morning fatigue, and nausea — but it's unclear whether California poppy caused these or the other ingredients did.
Does California Poppy actually work for sleep or anxiety?
The evidence we hold doesn't reliably show that it works for insomnia or anxiety. The available studies are insufficient to make that call — so we can't say it does or doesn't based on our data.
Why does the label say it's for anxiety if there's no proof it works?
California poppy has been used traditionally for relaxation, which is why it appears in products aimed at these concerns. But traditional use and proven effectiveness are two different things — the evidence just doesn't back up the claim yet.
Is this safe for short-term use?
It's generally considered mild for short-term use, though human safety data are limited. If you're thinking of taking it long-term or if you have other health conditions or take medications, run it by your doctor or pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if California Poppy is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

California Poppy label
Go deeper

The Full Monographs Behind California Poppy’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

California Poppy

Interacts with 248 drugs

California poppy is a traditional herbal remedy used mainly for anxiety and sleep problems, often combined with other calming herbs. Human research is very limited, so its true benefits are...

Read the full California Poppy monograph →
Sources

Sources & How We Checked

California Poppy's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

California Poppy 3 references
  1. Hanus M, Lafon J, Mathieu M. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate
  2. Paul LD, Springer D, Staack RF, et al. Cytochrome P450 isoenzymes involved in rat liver microsomal metabolism of californine and protopine. Eur J Pharmacol 2004;485:69-79. PubMed
  3. Paul LD, Maurer HH. Studies on the metabolism and toxicological detection of the Eschscholtzia californica alkaloids californine and protopine in urine using gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2003;789:43-5

See these in context on the California Poppy monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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