Acetazolamide
Acetazolamide is a carbonic anhydrase inhibitor (a type of water pill and fluid-pressure reducer) used alongside other treatment for glaucoma, and, depending on the product, for fluid retention, certain seizure disorders, and acute mountain sickness.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 52 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
Acetazolamide is an older standby, on the U.S. market since the 1950s and available as a generic, that blocks an enzyme called carbonic anhydrase to lower eye pressure and draw extra fluid out through the kidneys; it is an add-on for glaucoma and, depending on the product, for heart failure swelling, certain seizures and mountain sickness. Most people manage short courses well, though tingling in the fingers, toes or face, extra urination and odd taste changes are common. It is a sulfa-type drug, so flag any sulfa allergy and get help quickly for a rash, blisters, mouth sores, fever, sore throat or unusual bruising.
Clinical pearls
- Avoid high-dose aspirin with it, since the combination can cause dangerous acid buildup in the blood.
- For mountain sickness prevention, starting it 24 to 48 hours before you go up is preferred.
- Phenytoin, primidone, lithium and diabetes medicines can all be thrown off by it, so tell every prescriber you take it.
- It is not used with cirrhosis or marked kidney disease, and long-term users need potassium checks and should report blood in the urine or kidney stone pain.
Patient information guide A plain-language walkthrough of Acetazolamide, written from its FDA label.
What Acetazolamide is used for
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Acetazolamide is used as an add-on treatment, and the approved uses vary by product.
- Glaucoma (open-angle, secondary, and before surgery in acute angle-closure): all products.
- Swelling from congestive heart failure: Acetazolamide tablets and injection.
- Drug-induced swelling: Acetazolamide tablets and injection.
- Certain epilepsies (petit mal, unlocalized seizures): Acetazolamide tablets and injection.
- Acute mountain sickness: Acetazolamide tablets, extended-release capsules, and one injection label.
How Acetazolamide works
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Acetazolamide blocks carbonic anhydrase, an enzyme that helps balance carbon dioxide and acid in the body. In the eye, this reduces fluid production and lowers eye pressure. In the kidney, it causes loss of bicarbonate, sodium, water and potassium, which increases urine output. In the brain, it appears to slow abnormal, excessive nerve firing.
Acetazolamide dosage
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Tablets and capsules are taken by mouth. The injection is given into a vein. Doses are adjusted to your condition, and glaucoma treatment needs ongoing physician supervision.
- Extended-release capsules for glaucoma: usually once in the morning and once in the evening.
- Mountain sickness: divided daily doses, ideally starting 24 to 48 hours before ascent and continuing during 48 hours at altitude or longer if needed.
- Injection: mixed with sterile water, given directly into a vein by a professional.
Follow your prescriber and label directions.
Dosing details from the FDA-approved label
From the Acetazolamide prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.
- Glaucoma (extended-release capsule)
- 1 capsule (500 mg) two times a day
- Usually 1 capsule in the morning and 1 capsule in the evening
- Maximum: Dosage in excess of 2 capsules (1 g) does not produce an increased effect
- Adjust with careful individual attention to symptomatology and intraocular tension; continuous supervision by a physician is advisable
- Chronic simple (open-angle) glaucoma (tablet or injection)
- 250 mg to 1 g of acetazolamide per 24 hours, usually in divided doses for amounts over 250 mg
- Used as an adjunct to the usual therapy
- Maximum: Dosage in excess of 1 g per 24 hours does not produce an increased effect
- Adjust with careful individual attention to symptomatology and ocular tension
- Secondary glaucoma and preoperative treatment of some cases of acute congestive (closed-angle) glaucoma
- 250 mg every four hours
- Some cases responded to 250 mg twice daily on short-term therapy
- In some acute cases an initial dose of 500 mg followed by 125 or 250 mg every four hours
- Intravenous therapy may be used for rapid relief of ocular tension in acute cases
- Epilepsy
- Suggested total daily dose 8 to 30 mg per kg in divided doses
- Optimum range appears to be 375 to 1000 mg daily
- When combined with other anticonvulsants, starting dose 250 mg once daily in addition to existing medications
- Maximum: Some investigators feel daily doses in excess of 1 g do not produce better results than a 1 g dose
- Change from other medications to acetazolamide should be gradual
- Congestive heart failure (diuresis)
- Starting dose usually 250 to 375 mg once daily in the morning (5 mg/kg)
- Best results given on alternate days, or for two days alternating with a day of rest
- If the patient fails to continue to lose edema fluid, do not increase the dose; skip medication for a day to allow kidney recovery
- Drug-induced edema
- 250 to 375 mg once a day for one or two days, alternating with a day of rest
- Acute mountain sickness
- 500 mg to 1000 mg daily, in divided doses using tablets or extended-release capsules as appropriate
- In rapid ascent the higher level of 1000 mg is recommended
- Preferably start 24 to 48 hours before ascent and continue for 48 hours at high altitude, or longer as necessary to control symptoms
Read the label’s full dosing text
DOSAGE AND ADMINISTRATION Glaucoma: Acetazolamide should be used as an adjunct to the usual therapy. The dosage employed in the treatment of chronic simple (open-angle) glaucoma ranges from 250 mg to 1 g of acetazolamide per 24 hours, usually in divided doses for amounts over 250 mg. It has usually been found that a dosage in excess of 1 g per 24 hours does not produce an increased effect. In all cases, the dosage should be adjusted with careful individual attention both to symptomatology and ocular tension. Continuous supervision by a physician is advisable. In treatment of secondary glaucoma and in the preoperative treatment of some cases of acute congestive (closed-angle) glaucoma, the preferred dosage is 250 mg every four hours, although some cases have responded to 250 mg twice daily on short-term therapy. In some acute cases, it may be more satisfactory to administer an initial dose of 500 mg followed by 125 or 250 mg every four hours depending on the individual case. Intravenous therapy may be used for rapid relief of ocular tension in acute cases. A complementary effect has been noted when acetazolamide has been used in conjunction with miotics or mydriatics as the case demanded. Epilepsy: It is not clearly known whether the beneficial effects observed in epilepsy are due to direct inhibition of carbonic anhydrase in the central nervous system or whether they are due to the slight degree of acidosis produced by the divided dosage. The best results to date have been seen in petit mal in pediatric patients. Good results, however, have been seen in patients, both pediatric patients and adult, in other types of seizures such as grand mal, mixed seizure patterns, myoclonic jerk patterns, etc. The suggested total daily dose is 8 to 30 mg per kg in divided doses. Although some patients respond to a low dose, the optimum range appears to be from 375 to 1000 mg daily. However, some investigators feel that daily doses in excess of 1 g do not produce any better results than a 1 g dose. When acetazolamide is given in combination with other anticonvulsants, it is suggested that the starting dose should be 250 mg once daily in addition to the existing medications. This can be increased to levels as indicated above. The change from other medications to acetazolamide should be gradual and in accordance with usual practice in epilepsy therapy.
Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →
Acetazolamide side effects
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Common effects include:
Common side effects
- Headache, tiredness and general unwell feeling
- Nausea, vomiting or diarrhea
- Loss of appetite or taste changes
- Tingling or numbness in hands, feet or face
- Drowsiness or dizziness
- Increased urination
- Ringing in the ears or hearing changes
- Headache, tiredness, malaise
When to get medical help
- Get help right away for a rash, blisters, peeling skin, or sores in the mouth. These can be signs of Stevens-Johnson syndrome or toxic epidermal necrolysis.
- Call your doctor for fever, sore throat, unusual bruising or bleeding, or pale skin. These can signal blood problems.
- Seek help for yellowing skin or eyes, or other signs of liver problems.
- Get urgent help for swelling of the face or throat or trouble breathing (anaphylaxis, a severe allergic reaction).
- Report confusion, convulsions, severe drowsiness or fast breathing.
- Report blood in urine or kidney stone symptoms, especially with long-term use.
- Report vision changes, such as sudden nearsightedness or eye problems.
Acetazolamide warnings and precautions
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- Rare, sometimes fatal sulfonamide reactions: severe skin reactions, liver failure, serious blood disorders, anaphylaxis.
- Stop the drug if signs of hypersensitivity or other serious reactions appear.
- Caution with high-dose aspirin: acid buildup, coma and death have been reported.
- Possible acid buildup, low potassium or sodium, and kidney stones with long-term use.
- Growth slowing has been reported in children.
Acetazolamide interactions
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These medicines and substances need caution:
- Aspirin (high dose): risk of serious acid buildup.
- Phenytoin: levels can rise and bone softening may worsen.
- Primidone: levels may fall, weakening seizure control.
- Other carbonic anhydrase inhibitors: not advisable together.
- Diabetes medicines: blood sugar can rise or fall.
- Lithium: excretion increases, so levels may drop.
- Amphetamines and quinidine: effects may be stronger or longer.
- Sodium bicarbonate: raises kidney stone risk.
- Cyclosporine: levels may rise.
- Methenamine: may not work as well.
Interactions listed in the FDA-approved label
From the Acetazolamide prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.
- Aspirin: The label refers to its WARNINGS section for this interaction. See WARNINGS
- Phenytoin: Acetazolamide modifies phenytoin metabolism with increased serum levels of phenytoin, which may increase the occurrence of osteomalacia in some patients on chronic phenytoin therapy. Caution is advised in patients receiving chronic concomitant therapy.
- Primidone: By decreasing gastrointestinal absorption of primidone, acetazolamide may decrease serum concentrations of primidone and its metabolites, with a possible decrease in anticonvulsant effect. Caution when beginning, discontinuing, or changing the dose of acetazolamide in patients receiving primidone.
- Other carbonic anhydrase inhibitors: Possible additive effects. Concomitant use is not advisable.
- Other folic acid antagonists: Acetazolamide may increase the effects of other folic acid antagonists.
- Antidiabetic agents: Acetazolamide may increase or decrease blood glucose levels. Consideration should be taken in patients being treated with antidiabetic agents.
- Amphetamine: Acetazolamide decreases urinary excretion of amphetamine and may enhance the magnitude and duration of its effect.
- Quinidine: Acetazolamide reduces urinary excretion of quinidine and may enhance its effect.
- Methenamine: Acetazolamide may prevent the urinary antiseptic effect of methenamine.
- Sodium bicarbonate: Used concurrently with acetazolamide, it increases the risk of renal calculus formation.
Read the label’s full interactions text
Drug Interactions Aspirin - See WARNINGS . Acetazolamide modifies phenytoin metabolism with increased serum levels of phenytoin. This may increase or enhance the occurrence of osteomalacia in some patients receiving chronic phenytoin therapy. Caution is advised in patients receiving chronic concomitant therapy. By decreasing the gastrointestinal absorption of primidone, acetazolamide may decrease serum concentrations of primidone and its metabolites, with a consequent possible decrease in anticonvulsant effect. Caution is advised when beginning, discontinuing, or changing the dose of acetazolamide in patients receiving primidone. Because of possible additive effects with other carbonic anhydrase inhibitors, concomitant use is not advisable. Acetazolamide may increase the effects of other folic acid antagonists. Acetazolamide may increase or decrease blood glucose levels. Consideration should be taken in patients being treated with antidiabetic agents. Acetazolamide decreases urinary excretion of amphetamine and may enhance the magnitude and duration of their effect. Acetazolamide reduces urinary excretion of quinidine and may enhance its effect. Acetazolamide may prevent the urinary antiseptic effect of methenamine. Acetazolamide increases lithium excretion and the lithium may be decreased. Acetazolamide and sodium bicarbonate used concurrently increases the risk of renal calculus formation. Acetazolamide may elevate cyclosporine levels.
Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.
Before taking Acetazolamide
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- Allergy to acetazolamide, its ingredients, or sulfa drugs.
- Low blood sodium or potassium.
- Marked kidney or liver disease, or cirrhosis.
- Adrenal gland failure or hyperchloremic acidosis.
- Chronic non-congestive angle-closure glaucoma (long-term use not appropriate).
- Children: growth slowing has been reported.
Acetazolamide overdose
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No specific antidote is known. Too much may cause electrolyte imbalance, acid buildup in the blood, and effects on the nervous system. Treatment is supportive, with monitoring of electrolytes and blood pH, and bicarbonate can usually correct the acidosis. Dialysis may help, especially with kidney failure.
What Acetazolamide does in the body
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Acetazolamide lowers eye fluid production and eye pressure. It increases urine output and makes urine more alkaline by causing loss of bicarbonate, sodium, water and potassium. In studies of mountain sickness, people taking it before and during rapid ascent had fewer and milder symptoms, better lung function, and less trouble sleeping.
How to store Acetazolamide
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Store at 20°C to 25°C (68°F to 77°F) .
Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
Supplements & herbs that interact with Acetazolamide
284 supplements and herbal products have documented interactions with Acetazolamide in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.
- Major · 15
- Moderate · 242
- Minor · 27
Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.
Nutrient depletion considerations
Acetazolamide has been associated with lower levels of 8 nutrients in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.
- Higher significance · 3
- Moderate · 2
- Unrated · 3
Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.
Acetazolamide: pharmacist answers to common questions
Quick, plain-English answers to the questions patients ask most about Acetazolamide — the kind of thing our pharmacy team would talk through with you at the counter.
What is acetazolamide for?
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How should I take it?
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What side effects are normal?
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When should I call my doctor right away?
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Can I take it with aspirin or other medicines?
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Who should not take it?
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Is Acetazolamide available over the counter?
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When was Acetazolamide first available?
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Who makes Acetazolamide?
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Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
More about Acetazolamide on HelloPharmacist
Acetazolamide forms and strengths (how it comes)
Acetazolamide is available in 4 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Tablet
How this form is used
- Acetazolamide tablets are used as an add-on for edema from congestive heart failure, drug-induced edema, and certain epilepsies.
- Acetazolamide tablets are also used for glaucoma and to prevent or ease acute mountain sickness.
- Acetazolamide tablets for glaucoma are used along with the usual therapy, often in divided doses through the day.
- Acetazolamide tablets for glaucoma should be adjusted carefully by a doctor, with continuing supervision.
Extended-release capsule
How this form is used
- Acetazolamide extended-release capsules are used as an add-on for glaucoma.
- Acetazolamide extended-release capsules are also used to prevent or ease acute mountain sickness.
- Acetazolamide extended-release capsules for glaucoma are usually taken once in the morning and once in the evening.
- Acetazolamide extended-release capsules for mountain sickness are taken in divided daily doses and continued for 48 hours at high altitude or longer if needed.
Injection
How this form is used
- Acetazolamide injection is used as an add-on for edema from congestive heart failure, drug-induced edema, and certain epilepsies.
- Acetazolamide injection is also used for glaucoma, including before surgery in acute angle-closure glaucoma.
- Acetazolamide injection vials are mixed with sterile water before use and contain no preservative, so unused portions are discarded.
- Acetazolamide injection is preferably given directly into a vein. Injection into muscle is not recommended.
Capsule
How this form is used
- Acetazolamide Extended-release capsules are used as an add-on for open-angle glaucoma, secondary glaucoma, and before surgery in acute angle-closure glaucoma.
- Acetazolamide Extended-release capsules are also used to prevent or ease acute mountain sickness.
- Acetazolamide Extended-release capsules for glaucoma are usually taken once in the morning and once in the evening.
- Acetazolamide Extended-release capsules for mountain sickness are taken in divided daily doses, starting 24 to 48 hours before ascent if possible.
Acetazolamide on the U.S. market: products, makers and brands
How Acetazolamide appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
38 companies list 73 Acetazolamide product records with the FDA, mostly as tablet, extended-release capsule, injection; the earliest marketing or approval year on record is 1953. Brand names on the directory include Diamox Sequels; the rest are generics.
FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
Also listed with the FDA, not a patient dose form: Powder (11) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
How widely Acetazolamide is used (Medicaid data)
A general measure of how commonly Acetazolamide is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Acetazolamide is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Acetazolamide prescribed? Of the 1,601 medications we measure, Acetazolamide ranks #450 by Medicaid prescriptions — more than 72% of them.
Utilization by Acetazolamide product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
acetazolamide 250 MG Oral Tablet Most dispensed
Summed across the 9 of 51 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197304
12 HR acetazolamide 500 MG Extended Release Oral Capsule
Summed across the 6 of 46 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 562524
acetazolamide 125 MG Oral Tablet
Summed across the 6 of 43 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197303
acetazolamide 500 MG Injection
Summed across the 2 of 8 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 307702
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Acetazolamide, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 23 of 148 listed Acetazolamide NDCs with Medicaid activity.
Compare Acetazolamide products
A representative set of FDA-listed product records for Acetazolamide — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Capsule | ||||
| 500 mg | Oral | American Health Packaging | ANDA | View NDC → |
| 500 mg | Oral | AvPAK | ANDA | View NDC → |
| 500 mg | Oral | Micro Labs Limited | ANDA | View NDC → |
| 500 mg | Oral | Zydus Lifesciences Limited | ANDA | View NDC → |
| 500 mg | Oral | Zydus Pharmaceuticals (USA) Inc. | ANDA | View NDC → |
| 💊Extended-release capsule | ||||
| 500 mg | Oral | A-S Medication Solutions | ANDA | View NDC → |
| 500 mg | Oral | Accord Healthcare Inc. | ANDA | View NDC → |
| 500 mg | Oral | Alembic Pharmaceuticals Inc. | ANDA | View NDC → |
| 500 mg | Oral | Alembic Pharmaceuticals Limited | ANDA | View NDC → |
| 500 mg | Oral | Bryant Ranch Prepack | ANDA | View NDC → |
| 500 mg | Oral | Chartwell RX, LLC | ANDA | View NDC → |
| 500 mg | Oral | Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. | ANDA | View NDC → |
| 500 mg | Oral | Ingenus Pharmaceuticals, LLC | ANDA | View NDC → |
| 500 mg | Oral | Remedyrepack Inc. | ANDA | View NDC → |
| 500 mg | Oral | Westminster Pharmaceuticals, LLC | ANDA | View NDC → |
| 💊Injection | ||||
| 500 mg/5 mL | Intravenous | Gland Pharma Limited | ANDA | View NDC → |
| 500 mg/5 mL | Intravenous | Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. × 2 listings | ANDA | View NDC → |
| 500 mg | Intravenous | Hikma Pharmaceuticals USA Inc. × 2 listings | ANDA | View NDC → |
| 500 mg/5 mL | Intravenous | Mylan Institutional LLC | ANDA | View NDC → |
| 500 mg/5 mL | Intravenous | Sagent Pharmaceuticals | ANDA | View NDC → |
| 500 mg/5 mL | Intravenous | XGen Pharmaceuticals DJB, Inc. | ANDA | View NDC → |
| 💊Tablet | ||||
| 125 mg | Oral | A-S Medication Solutions | ANDA | View NDC → |
| 250 mg | Oral | A-S Medication Solutions × 2 listings | ANDA | View NDC → |
| 125 mg | Oral | Aarkish Pharmaceuticals NJ Inc. | ANDA | View NDC → |
| 250 mg | Oral | Aarkish Pharmaceuticals NJ Inc. | ANDA | View NDC → |
| 125 mg | Oral | Advagen Pharma Ltd | ANDA | View NDC → |
| 250 mg | Oral | Advagen Pharma Ltd | ANDA | View NDC → |
| 125 mg | Oral | Ajanta Pharma USA Inc. | ANDA | View NDC → |
| 250 mg | Oral | Ajanta Pharma USA Inc. | ANDA | View NDC → |
| 125 mg | Oral | ANI Pharmaceuticals, Inc. | ANDA | View NDC → |
| 250 mg | Oral | ANI Pharmaceuticals, Inc. | ANDA | View NDC → |
| 125 mg | Oral | Aurobindo Pharma Limited | ANDA | View NDC → |
| 250 mg | Oral | Aurobindo Pharma Limited | ANDA | View NDC → |
| 125 mg | Oral | AvKARE | ANDA | View NDC → |
| 250 mg | Oral | AvKARE | ANDA | View NDC → |
| 250 mg | Oral | AvPAK | ANDA | View NDC → |
| 125 mg | Oral | Bryant Ranch Prepack × 2 listings | ANDA | View NDC → |
| 250 mg | Oral | Bryant Ranch Prepack × 3 listings | ANDA | View NDC → |
| 125 mg | Oral | Chartwell RX, LLC | ANDA | View NDC → |
| 250 mg | Oral | Chartwell RX, LLC | ANDA | View NDC → |
| 125 mg | Oral | Eywa Pharma Inc | ANDA | View NDC → |
| 250 mg | Oral | Eywa Pharma Inc | ANDA | View NDC → |
| 125 mg | Oral | Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. | ANDA | View NDC → |
| 250 mg | Oral | Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. | ANDA | View NDC → |
| 125 mg | Oral | Lifestar Pharma LLC | ANDA | View NDC → |
| 250 mg | Oral | Lifestar Pharma LLC | ANDA | View NDC → |
| 250 mg | Oral | Major Pharmaceuticals | ANDA | View NDC → |
| 125 mg | Oral | Marlex Pharmaceuticals, Inc. | ANDA | View NDC → |
| 250 mg | Oral | Marlex Pharmaceuticals, Inc. | ANDA | View NDC → |
| 125 mg | Oral | Northwind Health Company, LLC | ANDA | View NDC → |
| 125 mg | Oral | NuCare Pharmaceuticals,Inc. × 2 listings | ANDA | View NDC → |
| 125 mg | Oral | NuCare Pharmaceuticlas, Inc. | ANDA | View NDC → |
| 125 mg | Oral | PD-Rx Pharmaceuticals, Inc. × 2 listings | ANDA | View NDC → |
| 250 mg | Oral | PD-Rx Pharmaceuticals, Inc. | ANDA | View NDC → |
| 125 mg | Oral | Proficient Rx LP | ANDA | View NDC → |
| 125 mg | Oral | Strides Pharma Science Limited | ANDA | View NDC → |
| 250 mg | Oral | Strides Pharma Science Limited | ANDA | View NDC → |
| 125 mg | Oral | Trupharma, Llc | ANDA | View NDC → |
| 250 mg | Oral | Trupharma, Llc | ANDA | View NDC → |
| 125 mg | Oral | Viona Pharmaceuticals Inc | ANDA | View NDC → |
| 250 mg | Oral | Viona Pharmaceuticals Inc | ANDA | View NDC → |
| 125 mg | Oral | Zydus Lifesciences Limited | ANDA | View NDC → |
| 250 mg | Oral | Zydus Lifesciences Limited | ANDA | View NDC → |
| 125 mg | Oral | Zydus Pharmaceuticals (USA) Inc. | ANDA | View NDC → |
| 250 mg | Oral | Zydus Pharmaceuticals (USA) Inc. | ANDA | View NDC → |
Showing 73 of 73 products — FDA National Drug Code Directory. See every product, package size and price: browse all 73 Acetazolamide NDCs →
Acetazolamide side effects reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Acetazolamide — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Acetazolamide in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
Acetazolamide FDA approval history
How Acetazolamide went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
Acetazolamide recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
The FDA’s enforcement reports list one Acetazolamide recall since July 2021. It is still ongoing. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.
- AcetaZOLAMIDE Tablets, USP, 125 mg, 100 count bottled, Rx Only, Distributed by: Advagen Pharma Limited, Plainsboro, NJ, Manufactured by Rubicon Research Private Limited, Thane, India NDC 72888-047-01 Lots: Lot # 30575HF1, exp. date, Nov 2026 NDC# 72888-047-01 FDA record D-0659-2024 →
Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 167 3 dose forms · 5 strengths
-
Dose form (SCDF) Extended Release Oral Capsule RxCUI 370526In current FDA listings -
Dose form (SCDF) Injection RxCUI 1719786In current FDA listingsClinical drug / strength (SCD) 500 MGRxCUI 307702 -
Dose form (SCDF) Oral Tablet RxCUI 370525In current FDA listings
Look up RxCUI 167 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
Acetazolamide supply and shortage status
Whether Acetazolamide is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
💵 What Acetazolamide costs pharmacies (NADAC benchmark)
The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.
| Form | Strength | Pharmacy acquisition benchmark | |
|---|---|---|---|
| Tablet · Oral | 250 mg | $0.134 per tablet | NDC details & price history |
| Capsule, Extended Release · Oral | 500 mg | $0.288 per capsule | NDC details & price history |
| Capsule · Oral | 500 mg | $0.288 per capsule | NDC details & price history |
Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.
Acetazolamide brand names
Acetazolamide is sold under one brand name in the FDA directory — Diamox Sequels. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.
Who makes Acetazolamide: manufacturers and labelers
38 companies list Acetazolamide products with the FDA. By number of product records, the largest are Bryant Ranch Prepack, Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc., A-S Medication Solutions. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.
…and 14 more on the FDA NDC directory.
Acetazolamide drug class (RxNorm)
Acetazolamide belongs to the Carbonic Anhydrase Inhibitor class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
Sources for this Acetazolamide page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How this page is built
HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Aurobindo Pharma Limited is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →