Ramelteon

Generic name: Pronounced as (ram el' tee on)
Brand names
  • Rozerem®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 04/15/2019

Ramelteon is used to help patients who have sleep-onset insomnia (difficulty falling asleep) fall asleep more quickly. Ramelteon is in a class of medications called melatonin receptor agonists. It works similarly to melatonin, a natural substance in the brain that is needed for sleep.

Ramelteon comes as a tablet to take by mouth. It is usually taken once a day, no earlier than 30 minutes before bedtime. Do not take ramelteon with or shortly after a meal. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ramelteon exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them.

You may become sleepy soon after you take ramelteon. After you take ramelteon, you should complete any necessary bedtime preparations and go to bed. Do not plan any other activities for this time. Do not take ramelteon if you will be unable to remain asleep for 7 to 8 hours after taking the medication.

Your insomnia should improve within 7 to 10 days after you begin treatment with ramelteon. Call your doctor if your insomnia does not improve during this time or gets worse at any time during your treatment.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with ramelteon and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking ramelteon,

  • tell your doctor and pharmacist if you are allergic to ramelteon, any other medications, or any of the ingredients in ramelteon tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor if you are taking fluvoxamine (Luvox). Your doctor will probably tell you not to take ramelteon while you are taking this medication.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: certain antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral); cimetidine (Tagamet); clarithromycin (Biaxin, in Prevpac); fluoroquinolones including ciprofloxacin (Cipro, Proquin XR), gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), norfloxacin (Noroxin), ofloxacin (Floxin), others; HIV protease inhibitors including indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra); medications for anxiety, pain or seizures; nefazodone; rifampin (Rifadin, in Rifamate, in Rifater, Rimactane); sedatives; other sleeping pills; ticlopidine (Ticlid); and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with ramelteon, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor if you have ever thought about killing yourself or planned or tried to do so, and if you have or have ever had chronic obstructive pulmonary disease (COPD, damage to the lungs that makes breathing difficult) or other lung disease, sleep apnea (condition in which you briefly stop breathing many times during the night) or other breathing problems, depression, mental illness, or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking ramelteon, call your doctor.

  • you should know that ramelteon may make you drowsy during the daytime. Do not drive a car or operate machinery until you know how this medication affects you.

  • do not drink alcohol during your treatment with ramelteon. Alcohol can make the side effects of ramelteon worse.

  • you should know that some people who took ramelteon got out of bed and drove their cars, prepared and ate food, had sex, made phone calls, or were involved in other activities while partially asleep. After they woke up, these people were usually unable to remember what they had done. Call your doctor right away if you find out that you have been driving or doing anything else unusual while you were sleeping.

  • you should know that your mental health may change in unexpected ways while you are taking this medication. It is hard to tell if these changes are caused by ramelteon or if they are caused by physical or mental illnesses that you already have or suddenly develop. Tell your doctor right away if you experience any of the following symptoms: agitation, anxiety, frenzied or abnormally excited mood, hallucinations (seeing things or hearing voices that do not exist), nightmares, memory problems, new or worsening depression, thinking about or trying to kill yourself, and any other changes in your usual thoughts, mood, or behavior. Be sure that your family knows which symptoms may be serious so that they can call the doctor if you are unable to seek treatment on your own.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication.

Ramelteon should only be taken at bedtime. If you did not take ramelteon at bedtime and you are unable to fall asleep, you may take ramelteon if you will be able to remain in bed for 7 to 8 hours afterward. Do not take ramelteon if you are not ready to go to sleep and stay asleep for at least 7 to 8 hours.

  • Ramelteon may cause side effects. Tell your doctor if either of these symptoms are severe or do not go away:

    • drowsiness or tiredness

    • dizziness

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • swelling of the tongue or throat

    • difficulty swallowing or breathing

    • feeling that the throat is closing

    • nausea

    • vomiting

    • irregular or missed menstrual periods

    • milky discharge from the nipples

    • decreased sexual desire

    • fertility problems

  • Ramelteon may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The metabolism of Ramelteon can be decreased when combined with Moxifloxacin.
Montelukast Montelukast The metabolism of Ramelteon can be decreased when combined with Montelukast.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The metabolism of Ramelteon can be increased when combined with Insulin glargine.
Leflunomide Leflunomide The serum concentration of Ramelteon can be decreased when it is combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Ramelteon can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Ramelteon can be decreased when combined with Nevirapine.
Dolasetron Dolasetron The risk or severity of adverse effects can be increased when Dolasetron is combined with Ramelteon.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Ramelteon.
Anagrelide Anagrelide The metabolism of Ramelteon can be decreased when combined with Anagrelide.
Candesartan Candesartan The metabolism of Ramelteon can be decreased when combined with Candesartan.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Ramelteon.
Clopidogrel Clopidogrel The metabolism of Ramelteon can be decreased when combined with Clopidogrel.
Diphenoxylate Diphenoxylate The risk or severity of adverse effects can be increased when Ramelteon is combined with Diphenoxylate.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The metabolism of Ramelteon can be decreased when combined with Conjugated estrogens.
Fenofibrate Fenofibrate The metabolism of Ramelteon can be decreased when combined with Fenofibrate.
Guanfacine Guanfacine The risk or severity of adverse effects can be increased when Ramelteon is combined with Guanfacine.
Magnesium Hydroxide Magnesium Hydroxide Ramelteon may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Mycophenolate Mycophenolate Ramelteon may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Naratriptan Naratriptan The risk or severity of adverse effects can be increased when Naratriptan is combined with Ramelteon.
Olsalazine Olsalazine Olsalazine may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Paregoric Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Ramelteon.
Pentazocine Pentazocine The risk or severity of adverse effects can be increased when Pentazocine is combined with Ramelteon.
Potassium Potassium Potassium may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone Prednisone may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Ranitidine Ranitidine The metabolism of Ramelteon can be decreased when combined with Ranitidine.
Reserpine Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Ramelteon.
Rizatriptan Rizatriptan The risk or severity of adverse effects can be increased when Rizatriptan is combined with Ramelteon.
Sumatriptan Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Ramelteon.
Tacrolimus Tacrolimus Tacrolimus may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Tizanidine Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Ramelteon.
Zolmitriptan Zolmitriptan The metabolism of Ramelteon can be decreased when combined with Zolmitriptan.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Famotidine Injection Famotidine Injection The metabolism of Ramelteon can be decreased when combined with Famotidine.
Fluconazole Injection Fluconazole Injection The metabolism of Ramelteon can be decreased when combined with Fluconazole.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Ramelteon.
Interferon Beta-1b Injection Interferon Beta-1b Injection The metabolism of Ramelteon can be decreased when combined with Interferon beta-1b.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The metabolism of Ramelteon can be decreased when combined with Interferon gamma-1b.
Levofloxacin Injection Levofloxacin Injection The metabolism of Levofloxacin can be decreased when combined with Ramelteon.
Meperidine Injection Meperidine Injection The risk or severity of adverse effects can be increased when Meperidine is combined with Ramelteon.
Metoclopramide Injection Metoclopramide Injection The risk or severity of sedation can be increased when Ramelteon is combined with Metoclopramide.
Metronidazole Injection Metronidazole Injection The metabolism of Ramelteon can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Ramelteon.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Ramelteon may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The metabolism of Ramelteon can be decreased when combined with Zidovudine.
Altretamine Altretamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Ramelteon.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Cyclosporine Cyclosporine Cyclosporine may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Ondansetron Ondansetron The metabolism of Ramelteon can be decreased when combined with Ondansetron.
Granisetron Granisetron The risk or severity of adverse effects can be increased when Granisetron is combined with Ramelteon.
Torsemide Torsemide The metabolism of Ramelteon can be decreased when combined with Torasemide.
Olanzapine Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Ramelteon.
Alosetron Alosetron The metabolism of Ramelteon can be decreased when combined with Alosetron.
Entacapone Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Ramelteon.
Meloxicam Meloxicam Meloxicam may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Oxcarbazepine Oxcarbazepine The metabolism of Ramelteon can be decreased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole The metabolism of Ramelteon can be decreased when combined with Pantoprazole.
Telmisartan Telmisartan The metabolism of Ramelteon can be decreased when combined with Telmisartan.
Temozolomide Temozolomide Temozolomide may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Zaleplon Zaleplon The risk or severity of adverse effects can be increased when Zaleplon is combined with Ramelteon.
Anakinra Anakinra The metabolism of Ramelteon can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of adverse effects can be increased when Desloratadine is combined with Ramelteon.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Ramelteon.
Trimipramine Trimipramine The metabolism of Ramelteon can be decreased when combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Ramelteon can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Modafinil Modafinil The metabolism of Ramelteon can be decreased when combined with Modafinil.
Perindopril Perindopril Perindopril may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Epinephrine Injection Epinephrine Injection The metabolism of Ramelteon can be decreased when combined with Epinephrine.
Eplerenone Eplerenone Eplerenone may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram Escitalopram The risk or severity of adverse effects can be increased when Ramelteon is combined with Escitalopram.
Zonisamide Zonisamide The risk or severity of adverse effects can be increased when Zonisamide is combined with Ramelteon.
Adalimumab Injection Adalimumab Injection The metabolism of Ramelteon can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The risk or severity of adverse effects can be increased when Ramelteon is combined with Aripiprazole.
Atomoxetine Atomoxetine The risk or severity of adverse effects can be increased when Atomoxetine is combined with Ramelteon.
Dexmethylphenidate Dexmethylphenidate The risk or severity of adverse effects can be increased when Ramelteon is combined with Dexmethylphenidate.
Atazanavir Atazanavir Atazanavir may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Almotriptan Almotriptan The risk or severity of adverse effects can be increased when Almotriptan is combined with Ramelteon.
Eletriptan Eletriptan The risk or severity of adverse effects can be increased when Eletriptan is combined with Ramelteon.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Ramelteon.
Aprepitant Aprepitant The metabolism of Ramelteon can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine Emtricitabine may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Interferon Beta-1a Subcutaneous Injection Interferon Beta-1a Subcutaneous Injection The metabolism of Ramelteon can be decreased when combined with Interferon beta-1a.
Memantine Memantine The metabolism of Ramelteon can be decreased when combined with Memantine.
Tegaserod Tegaserod The metabolism of Ramelteon can be decreased when combined with Tegaserod.
Tadalafil Tadalafil Tadalafil may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Frovatriptan Frovatriptan The metabolism of Frovatriptan can be decreased when combined with Ramelteon.
Gemifloxacin Gemifloxacin The metabolism of Ramelteon can be decreased when combined with Gemifloxacin.
Progesterone Progesterone The metabolism of Ramelteon can be decreased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Ramelteon.
Infliximab Injection Infliximab Injection The metabolism of Ramelteon can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Ramelteon can be decreased when combined with Oxandrolone.
Protriptyline Protriptyline The risk or severity of adverse effects can be increased when Protriptyline is combined with Ramelteon.
Rifaximin Rifaximin The metabolism of Ramelteon can be increased when combined with Rifaximin.
Duloxetine Duloxetine The risk or severity of adverse effects can be increased when Ramelteon is combined with Duloxetine.
Tinidazole Tinidazole Tinidazole may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Trospium Trospium Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan Bosentan The metabolism of Ramelteon can be increased when combined with Bosentan.
Cefditoren Cefditoren Cefdinir may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Cinacalcet Cinacalcet The metabolism of Cinacalcet can be decreased when combined with Ramelteon.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Erlotinib Erlotinib The metabolism of Ramelteon can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The risk or severity of CNS depression can be increased when Ramelteon is combined with Eszopiclone.
Ganciclovir Ganciclovir Ramelteon may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Ribavirin Ribavirin Ribavirin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Solifenacin Solifenacin Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Valganciclovir Valganciclovir Ramelteon may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole Voriconazole The metabolism of Ramelteon can be decreased when combined with Voriconazole.
Adefovir Adefovir Adefovir may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Ramelteon.
Entecavir Entecavir The metabolism of Ramelteon can be decreased when combined with Entecavir.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The metabolism of Ramelteon can be decreased when combined with Peginterferon alfa-2a.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The serum concentration of Ramelteon can be increased when it is combined with Peginterferon alfa-2b.
Sodium Oxybate Sodium Oxybate Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Isocarboxazid Isocarboxazid The risk or severity of adverse effects can be increased when Ramelteon is combined with Isocarboxazid.
Darifenacin Darifenacin Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Darifenacin.
Fentanyl Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Ramelteon.
Pregabalin Pregabalin The therapeutic efficacy of Ramelteon can be increased when used in combination with Pregabalin.
Deferasirox Deferasirox The serum concentration of Ramelteon can be increased when it is combined with Deferasirox.
Phenylephrine Phenylephrine The metabolism of Ramelteon can be increased when combined with Phenylephrine.
Tipranavir Tipranavir The metabolism of Ramelteon can be decreased when combined with Tipranavir.
Felbamate Felbamate The metabolism of Ramelteon can be decreased when combined with Felbamate.
Ranolazine Ranolazine Ranolazine may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Abatacept Injection Abatacept Injection The metabolism of Ramelteon can be increased when combined with Abatacept.
Rasagiline Rasagiline The risk or severity of adverse effects can be increased when Ramelteon is combined with Rasagiline.
Imatinib Imatinib The metabolism of Ramelteon can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin Ramelteon may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Varenicline Varenicline Ramelteon may decrease the excretion rate of Varenicline which could result in a higher serum level.
Gefitinib Gefitinib The metabolism of Ramelteon can be decreased when combined with Gefitinib.
Albuterol Albuterol Ramelteon may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone Paliperidone The risk or severity of adverse effects can be increased when Ramelteon is combined with Paliperidone.
Bortezomib Bortezomib The metabolism of Ramelteon can be decreased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection Clofarabine may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The metabolism of Ramelteon can be increased when combined with Insulin glulisine.
Lubiprostone Lubiprostone Ramelteon may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Primaquine Primaquine The metabolism of Ramelteon can be decreased when combined with Primaquine.
Pemetrexed Injection Pemetrexed Injection Ramelteon may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dimenhydrinate Dimenhydrinate The risk or severity of adverse effects can be increased when Ramelteon is combined with Dimenhydrinate.
Nabilone Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.
Sorafenib Sorafenib The metabolism of Ramelteon can be decreased when combined with Sorafenib.
Dronabinol Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Ramelteon.
Levocetirizine Levocetirizine The risk or severity of adverse effects can be increased when Ramelteon is combined with Levocetirizine.
Pegaptanib Injection Pegaptanib Injection Ramelteon may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Ramelteon.
Mexiletine Mexiletine The metabolism of Ramelteon can be decreased when combined with Mexiletine.
Armodafinil Armodafinil The metabolism of Ramelteon can be decreased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection Azacitidine may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Lenalidomide Lenalidomide Lenalidomide may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Nilotinib Nilotinib The metabolism of Ramelteon can be decreased when combined with Nilotinib.
Bexarotene Bexarotene The metabolism of Ramelteon can be decreased when combined with Bexarotene.
Budesonide Budesonide Ramelteon may decrease the excretion rate of Budesonide which could result in a higher serum level.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Ramelteon can be decreased when combined with Chloramphenicol.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Ramelteon.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Ramelteon.
Doripenem Injection Doripenem Injection Ramelteon may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine Etravirine The metabolism of Ramelteon can be decreased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection Ramelteon may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Desvenlafaxine Desvenlafaxine The risk or severity of adverse effects can be increased when Ramelteon is combined with Desvenlafaxine.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Ramelteon.
Tretinoin Tretinoin The metabolism of Ramelteon can be decreased when combined with Tretinoin.
Bendamustine Injection Bendamustine Injection The metabolism of Bendamustine can be decreased when combined with Ramelteon.
Flecainide Flecainide The metabolism of Ramelteon can be decreased when combined with Flecainide.
Certolizumab Injection Certolizumab Injection The metabolism of Ramelteon can be increased when combined with Certolizumab pegol.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Ramelteon.
Methylnaltrexone Injection Methylnaltrexone Injection Ramelteon may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Rufinamide Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Ramelteon.
Midazolam Midazolam The risk or severity of adverse effects can be increased when Midazolam is combined with Ramelteon.
Dexrazoxane Injection Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Ramelteon.
Milnacipran Milnacipran The risk or severity of adverse effects can be increased when Ramelteon is combined with Milnacipran.
Dexlansoprazole Dexlansoprazole The metabolism of Ramelteon can be decreased when combined with Dexlansoprazole.
Plerixafor Injection Plerixafor Injection Ramelteon may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine Fesoterodine Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Betaxolol Betaxolol The metabolism of Ramelteon can be decreased when combined with Betaxolol.
Iloperidone Iloperidone The risk or severity of adverse effects can be increased when Ramelteon is combined with Iloperidone.
Prasugrel Prasugrel Ramelteon may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Lacosamide Lacosamide The risk or severity of adverse effects can be increased when Ramelteon is combined with Lacosamide.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Ramelteon.
Pralatrexate Injection Pralatrexate Injection Ramelteon may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Ramelteon.
Saxagliptin Saxagliptin Ramelteon may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection Telavancin Injection Ramelteon may decrease the excretion rate of Telavancin which could result in a higher serum level.
Tapentadol Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.
Topotecan Topotecan Ramelteon may decrease the excretion rate of Topotecan which could result in a higher serum level.
Golimumab Injection Golimumab Injection The metabolism of Ramelteon can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Ramelteon.
Asenapine Asenapine The risk or severity of adverse effects can be increased when Ramelteon is combined with Asenapine.
Vigabatrin Vigabatrin The risk or severity of adverse effects can be increased when Ramelteon is combined with Vigabatrin.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Ramelteon.
Albendazole Albendazole The metabolism of Ramelteon can be decreased when combined with Albendazole.
Oxymorphone Oxymorphone The risk or severity of adverse effects can be increased when Ramelteon is combined with Oxymorphone.
Tocilizumab Injection Tocilizumab Injection The metabolism of Ramelteon can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine Ramelteon may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Ramelteon.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Lurasidone Lurasidone The risk or severity of adverse effects can be increased when Ramelteon is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection The metabolism of Ramelteon can be decreased when combined with Acetaminophen.
Vilazodone Vilazodone The risk or severity of adverse effects can be increased when Ramelteon is combined with Vilazodone.
Ipilimumab Injection Ipilimumab Injection Ramelteon may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Terbutaline may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Roflumilast Roflumilast Ramelteon may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Ramelteon can be decreased when combined with Cyclophosphamide.
Abiraterone Abiraterone The serum concentration of Ramelteon can be increased when it is combined with Abiraterone.
Rivaroxaban Rivaroxaban Ramelteon may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor Ticagrelor The metabolism of Ramelteon can be decreased when combined with Ticagrelor.
Ruxolitinib Ruxolitinib Ramelteon may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Clobazam Clobazam The risk or severity of adverse effects can be increased when Clobazam is combined with Ramelteon.
Vemurafenib Vemurafenib The serum concentration of Ramelteon can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Ramelteon can be decreased when combined with Vismodegib.
Deferiprone Deferiprone Ramelteon may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Ramelteon.
Cabergoline Cabergoline The risk or severity of adverse effects can be increased when Cabergoline is combined with Ramelteon.
Naloxone Injection Naloxone Injection Ramelteon may decrease the excretion rate of Naloxone which could result in a higher serum level.
Fondaparinux Injection Fondaparinux Injection Fondaparinux may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Ezogabine Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Ramelteon.
Enzalutamide Enzalutamide The metabolism of Ramelteon can be increased when combined with Enzalutamide.
Mirabegron Mirabegron Ramelteon may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Regorafenib Regorafenib The metabolism of Ramelteon can be decreased when combined with Regorafenib.
Teriflunomide Teriflunomide The serum concentration of Ramelteon can be decreased when it is combined with Teriflunomide.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Ramelteon.
Teduglutide Injection Teduglutide Injection Ramelteon may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Alogliptin Alogliptin Ramelteon may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Pomalidomide Pomalidomide The risk or severity of adverse effects can be increased when Ramelteon is combined with Pomalidomide.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Ramelteon.
Canagliflozin Canagliflozin Ramelteon may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib Dabrafenib The serum concentration of Ramelteon can be decreased when it is combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Ramelteon.
Trametinib Trametinib Ramelteon may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran The risk or severity of adverse effects can be increased when Ramelteon is combined with Levomilnacipran.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Vortioxetine Vortioxetine The risk or severity of adverse effects can be increased when Ramelteon is combined with Vortioxetine.
Perampanel Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Simeprevir Simeprevir The metabolism of Ramelteon can be decreased when combined with Simeprevir.
Sofosbuvir Sofosbuvir Ramelteon may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin The metabolism of Ramelteon can be decreased when combined with Dapagliflozin.
Apremilast Apremilast The metabolism of Ramelteon can be increased when combined with Apremilast.
Droxidopa Droxidopa Ramelteon may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib Ceritinib The metabolism of Ramelteon can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Ramelteon can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The risk or severity of adverse effects can be increased when Ramelteon is combined with Eslicarbazepine.
Belinostat Injection Belinostat Injection The metabolism of Ramelteon can be increased when combined with Belinostat.
Testosterone Injection Testosterone Injection The metabolism of Ramelteon can be decreased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Ramelteon can be decreased when combined with Oritavancin.
Hydrocodone Hydrocodone Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Suvorexant Suvorexant Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Edoxaban Edoxaban Ramelteon may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The metabolism of Ramelteon can be decreased when combined with Peginterferon beta-1a.
Methamphetamine Methamphetamine The risk or severity of adverse effects can be increased when Ramelteon is combined with Metamfetamine.
Tasimelteon Tasimelteon The risk or severity of adverse effects can be increased when Ramelteon is combined with Tasimelteon.
Pirfenidone Pirfenidone The metabolism of Pirfenidone can be decreased when combined with Ramelteon.
Secukinumab Injection Secukinumab Injection The metabolism of Ramelteon can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of adverse effects can be increased when Risperidone is combined with Ramelteon.
Insulin Human Inhalation Insulin Human Inhalation The metabolism of Ramelteon can be increased when combined with Insulin human.
Lenvatinib Lenvatinib The metabolism of Ramelteon can be decreased when combined with Lenvatinib.
Naloxegol Naloxegol The metabolism of Ramelteon can be decreased when combined with Naloxegol.
Haloperidol Injection Haloperidol Injection The risk or severity of CNS depression can be increased when Haloperidol is combined with Ramelteon.
Amiloride Amiloride Amiloride may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan Macitentan Ramelteon may decrease the excretion rate of Macitentan which could result in a higher serum level.
Flibanserin Flibanserin The risk or severity of adverse effects can be increased when Ramelteon is combined with Flibanserin.
Brexpiprazole Brexpiprazole The risk or severity of adverse effects can be increased when Ramelteon is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Ramelteon.
Cariprazine Cariprazine The risk or severity of adverse effects can be increased when Ramelteon is combined with Cariprazine.
Penicillin G Procaine Injection Penicillin G Procaine Injection Ramelteon may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The metabolism of Ramelteon can be increased when combined with Insulin degludec.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Ramelteon.
Osimertinib Osimertinib The serum concentration of Ramelteon can be decreased when it is combined with Osimertinib.
Ixazomib Ixazomib Ramelteon may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Rifapentine Rifapentine The metabolism of Ramelteon can be increased when combined with Rifapentine.
Lesinurad Lesinurad Ramelteon may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Brivaracetam Injection Brivaracetam Injection The risk or severity of adverse effects can be increased when Ramelteon is combined with Brivaracetam.
Pimavanserin Pimavanserin The risk or severity of adverse effects can be increased when Ramelteon is combined with Pimavanserin.
Obeticholic Acid Obeticholic Acid The metabolism of Ramelteon can be decreased when combined with Obeticholic acid.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of adverse effects can be increased when Ramelteon is combined with Diphenhydramine.
Furosemide Injection Furosemide Injection Furosemide may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib Rucaparib The metabolism of Ramelteon can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection Ramelteon may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Doxepin (Insomnia) Doxepin (Insomnia) Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Deutetrabenazine Deutetrabenazine The risk or severity of sedation and somnolence can be increased when Ramelteon is combined with Deutetrabenazine.
Valbenazine Valbenazine Ramelteon may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Safinamide Safinamide The metabolism of Ramelteon can be decreased when combined with Safinamide.
Naldemedine Naldemedine Ramelteon may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Midostaurin Midostaurin The serum concentration of Ramelteon can be increased when it is combined with Midostaurin.
Enasidenib Enasidenib The metabolism of Ramelteon can be decreased when combined with Enasidenib.
Benznidazole Benznidazole Ramelteon may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin Ramelteon may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Letermovir Letermovir The metabolism of Ramelteon can be increased when combined with Letermovir.
Tetrabenazine Tetrabenazine The risk or severity of sedation and somnolence can be increased when Ramelteon is combined with Tetrabenazine.
Ertugliflozin Ertugliflozin Ertugliflozin may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection Buprenorphine Injection Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide Apalutamide The serum concentration of Ramelteon can be increased when it is combined with Apalutamide.
Avatrombopag Avatrombopag The metabolism of Ramelteon can be increased when combined with Avatrombopag.
Baricitinib Baricitinib Ramelteon may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine The therapeutic efficacy of Ramelteon can be increased when used in combination with Lofexidine.
Plazomicin Injection Plazomicin Injection Ramelteon may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Binimetinib Binimetinib The metabolism of Binimetinib can be decreased when combined with Ramelteon.
Cannabidiol Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Ramelteon.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Ramelteon.
Stiripentol Stiripentol The metabolism of Ramelteon can be decreased when combined with Stiripentol.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Ramelteon.
Rifamycin Rifamycin The metabolism of Ramelteon can be increased when combined with Rifamycin.
Prucalopride Prucalopride Ramelteon may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Ramelteon can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Ramelteon.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Ramelteon.
Esomeprazole Injection Esomeprazole Injection The metabolism of Ramelteon can be decreased when combined with Esomeprazole.
Alpelisib Alpelisib The serum concentration of Ramelteon can be decreased when it is combined with Alpelisib.
Brexanolone Injection Brexanolone Injection The risk or severity of adverse effects can be increased when Ramelteon is combined with Brexanolone.
Solriamfetol Solriamfetol The risk or severity of adverse effects can be increased when Ramelteon is combined with Solriamfetol.
Triclabendazole Triclabendazole The metabolism of Ramelteon can be decreased when combined with Triclabendazole.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Ramelteon.
Pitolisant Pitolisant The serum concentration of Ramelteon can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The metabolism of Fedratinib can be decreased when combined with Ramelteon.
Phenytoin Injection Phenytoin Injection The metabolism of Ramelteon can be decreased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Ramelteon.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Ramelteon.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Ramelteon.
Lumateperone Lumateperone The risk or severity of adverse effects can be increased when Ramelteon is combined with Lumateperone.
Lasmiditan Lasmiditan The risk or severity of adverse effects can be increased when Ramelteon is combined with Lasmiditan.
Cenobamate Cenobamate The serum concentration of Ramelteon can be decreased when it is combined with Cenobamate.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Ramelteon.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Ramelteon.
Capmatinib Capmatinib The metabolism of Ramelteon can be decreased when combined with Capmatinib.
Lemborexant Lemborexant The risk or severity of adverse effects can be increased when Ramelteon is combined with Lemborexant.
Fenfluramine Fenfluramine The risk or severity of adverse effects can be increased when Fenfluramine is combined with Ramelteon.
Pralsetinib Pralsetinib The metabolism of Ramelteon can be decreased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Ramelteon can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine Viloxazine The risk or severity of adverse effects can be increased when Ramelteon is combined with Viloxazine.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Theophylline Theophylline The metabolism of Ramelteon can be decreased when combined with Theophylline.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Indomethacin Indomethacin Indomethacin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid Mefenamic acid may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Naproxen Naproxen Naproxen may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Trazodone Trazodone The risk or severity of adverse effects can be increased when Ramelteon is combined with Trazodone.
Isotretinoin Isotretinoin Ramelteon may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Floxuridine Floxuridine The metabolism of Ramelteon can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Ramelteon.
Metaxalone Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Ramelteon.
Methotrexate Injection Methotrexate Injection Methotrexate may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Levorphanol Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Ramelteon.
Primidone Primidone The metabolism of Ramelteon can be increased when combined with Primidone.
Methsuximide Methsuximide The risk or severity of adverse effects can be increased when Ramelteon is combined with Methsuximide.
Diethylpropion Diethylpropion The risk or severity of adverse effects can be increased when Diethylpropion is combined with Ramelteon.
Chlorpromazine Chlorpromazine The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Ramelteon.
Diazepam Diazepam The risk or severity of adverse effects can be increased when Diazepam is combined with Ramelteon.
Oxazepam Oxazepam The risk or severity of adverse effects can be increased when Oxazepam is combined with Ramelteon.
Flurazepam Flurazepam The risk or severity of adverse effects can be increased when Flurazepam is combined with Ramelteon.
Clorazepate Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Ramelteon.
Lorazepam Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Ramelteon.
Carmustine Carmustine The metabolism of Ramelteon can be decreased when combined with Carmustine.
Amantadine Amantadine Amantadine may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Codeine Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Ramelteon.
Meprobamate Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Ramelteon.
Chlordiazepoxide Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Ramelteon.
Bromocriptine Bromocriptine The risk or severity of adverse effects can be increased when Ramelteon is combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Ramelteon can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Ramelteon can be decreased when combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Ramelteon is combined with Procarbazine.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of adverse effects can be increased when Ramelteon is combined with Ergoloid mesylate.
Tetracycline Tetracycline Tetracycline may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.
Prochlorperazine Prochlorperazine The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Ramelteon.
Thioridazine Thioridazine The risk or severity of adverse effects can be increased when Thioridazine is combined with Ramelteon.
Trifluoperazine Trifluoperazine The risk or severity of adverse effects can be increased when Trifluoperazine is combined with Ramelteon.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Dapsone Dapsone The metabolism of Ramelteon can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The metabolism of Ramelteon can be decreased when combined with Sulfadiazine.
Oxycodone Oxycodone The risk or severity of adverse effects can be increased when Oxycodone is combined with Ramelteon.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Ramelteon.
Oxybutynin Oxybutynin Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Oxybutynin.
Benztropine Benztropine Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
Maprotiline Maprotiline Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
Ibuprofen Ibuprofen Ibuprofen may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Trihexyphenidyl Trihexyphenidyl Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine Orphenadrine Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine Perphenazine The risk or severity of adverse effects can be increased when Perphenazine is combined with Ramelteon.
Azathioprine Azathioprine The metabolism of Azathioprine can be decreased when combined with Ramelteon.
Fluphenazine Fluphenazine The risk or severity of adverse effects can be increased when Fluphenazine is combined with Ramelteon.
Methylphenidate Methylphenidate Methylphenidate may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Amoxapine Amoxapine Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Carbamazepine Carbamazepine The metabolism of Ramelteon can be increased when combined with Carbamazepine.
Molindone Molindone The risk or severity of adverse effects can be increased when Ramelteon is combined with Molindone.
Methyldopa Methyldopa Methyldopa may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Ramelteon.
Hydralazine Hydralazine Ramelteon may decrease the excretion rate of Hydralazine which could result in a higher serum level.
Cimetidine Cimetidine The metabolism of Ramelteon can be decreased when combined with Cimetidine.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Warfarin Warfarin The metabolism of Ramelteon can be decreased when combined with Warfarin.
Clonazepam Clonazepam The risk or severity of adverse effects can be increased when Ramelteon is combined with Clonazepam.
Promethazine Promethazine The risk or severity of adverse effects can be increased when Ramelteon is combined with Promethazine.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Ramelteon can be increased when combined with Griseofulvin.
Digoxin Digoxin Ramelteon may decrease the excretion rate of Digoxin which could result in a higher serum level.
Loxapine Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Ramelteon.
Chloroquine Chloroquine Chloroquine may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Quinine Quinine The metabolism of Ramelteon can be decreased when combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of adverse effects can be increased when Ethosuximide is combined with Ramelteon.
Triamterene Triamterene The metabolism of Ramelteon can be decreased when combined with Triamterene.
Sulfinpyrazone Sulfinpyrazone The metabolism of Ramelteon can be decreased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide Chlorothiazide may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone Chlorthalidone Chlorthalidone may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone Metolazone Metolazone may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide Isosorbide may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Ramelteon.
Desipramine Desipramine Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Amitriptyline Amitriptyline Amitriptyline may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.
Imipramine Imipramine The metabolism of Imipramine can be decreased when combined with Ramelteon.
Probenecid Probenecid The metabolism of Ramelteon can be decreased when combined with Probenecid.
Quinidine Quinidine The serum concentration of Ramelteon can be increased when it is combined with Quinidine.
Procainamide Procainamide Ramelteon may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid The metabolism of Ramelteon can be decreased when combined with Isoniazid.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Rifampin Rifampin The metabolism of Ramelteon can be increased when combined with Rifampicin.
Disopyramide Disopyramide The metabolism of Ramelteon can be decreased when combined with Disopyramide.
Valproic Acid Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Ramelteon.
Tamoxifen Tamoxifen The metabolism of Ramelteon can be decreased when combined with Tamoxifen.
Butabarbital Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Ramelteon.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Methimazole Methimazole The metabolism of Ramelteon can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide Chlorpropamide may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Tolbutamide Tolbutamide Ramelteon may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolazamide Tolazamide Tolazamide may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Dextromethorphan Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Ramelteon.
Cyclobenzaprine Cyclobenzaprine The risk or severity of CNS depression can be increased when Ramelteon is combined with Cyclobenzaprine.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Ramelteon.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.
Cyproheptadine Cyproheptadine Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
Clemastine Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Ramelteon.
Chlorpheniramine Chlorpheniramine The risk or severity of adverse effects can be increased when Ramelteon is combined with Chlorpheniramine.
Brompheniramine Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Ramelteon.
Meclizine Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Ramelteon.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Methyclothiazide Methyclothiazide Methyclothiazide may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Dantrolene Dantrolene The risk or severity of adverse effects can be increased when Ramelteon is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Ramelteon.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Ramelteon.
Methocarbamol Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Ramelteon.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Ramelteon can be decreased when combined with Propranolol.
Nortriptyline Nortriptyline Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Phytonadione Phytonadione Ramelteon may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Nadolol Nadolol Ramelteon may decrease the excretion rate of Nadolol which could result in a higher serum level.
Butorphanol Injection Butorphanol Injection The risk or severity of adverse effects can be increased when Butorphanol is combined with Ramelteon.
Nalbuphine Injection Nalbuphine Injection The risk or severity of adverse effects can be increased when Nalbuphine is combined with Ramelteon.
Allopurinol Allopurinol Allopurinol may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Trimethobenzamide Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Ramelteon.
Flavoxate Flavoxate Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Fluorouracil Injection Fluorouracil Injection The metabolism of Ramelteon can be decreased when combined with Fluorouracil.
Colchicine Colchicine Ramelteon may decrease the excretion rate of Colchicine which could result in a higher serum level.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Dacarbazine Dacarbazine The metabolism of Ramelteon can be decreased when combined with Dacarbazine.
Acetazolamide Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Ramelteon.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Ketoconazole Ketoconazole The metabolism of Ramelteon can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel The risk or severity of adverse effects can be increased when Ramelteon is combined with Pyrantel.
Ethacrynic Acid Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Metoprolol Metoprolol Metoprolol may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Hydroxyzine Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.
Thiothixene Thiothixene The risk or severity of adverse effects can be increased when Ramelteon is combined with Thiothixene.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Salsalate Salsalate Salsalate may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Alprazolam Alprazolam The risk or severity of adverse effects can be increased when Alprazolam is combined with Ramelteon.
Temazepam Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Ramelteon.
Triazolam Triazolam The risk or severity of adverse effects can be increased when Triazolam is combined with Ramelteon.
Dicyclomine Dicyclomine Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine Hyoscyamine Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline Propantheline Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Trimethoprim Trimethoprim Trimethoprim may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Diltiazem Diltiazem The metabolism of Ramelteon can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Nifedipine can be decreased when combined with Ramelteon.
Timolol Timolol The metabolism of Ramelteon can be decreased when combined with Timolol.
Verapamil Verapamil The metabolism of Ramelteon can be decreased when combined with Verapamil.
Pindolol Pindolol The risk or severity of adverse effects can be increased when Pindolol is combined with Ramelteon.
Cisplatin Injection Cisplatin Injection Ramelteon may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal Diflunisal may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Piroxicam Piroxicam Piroxicam may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Bumetanide Bumetanide Bumetanide may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
Streptozocin Streptozocin The metabolism of Ramelteon can be increased when combined with Streptozocin.
Etoposide Etoposide The metabolism of Ramelteon can be decreased when combined with Etoposide.
Glyburide Glyburide The metabolism of Ramelteon can be decreased when combined with Glyburide.
Glipizide Glipizide Ramelteon may decrease the excretion rate of Glipizide which could result in a higher serum level.
Indapamide Indapamide Indapamide may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin Amoxicillin Ramelteon may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Nafcillin Injection Nafcillin Injection The metabolism of Ramelteon can be increased when combined with Nafcillin.
Oxacillin Injection Oxacillin Injection Oxacillin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Pentoxifylline Pentoxifylline The metabolism of Ramelteon can be decreased when combined with Pentoxifylline.
Pentamidine Injection Pentamidine Injection Pentamidine may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Labetalol Labetalol The metabolism of Ramelteon can be decreased when combined with Labetalol.
Auranofin Auranofin Ramelteon may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Leuprolide may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Gemfibrozil Gemfibrozil The metabolism of Ramelteon can be decreased when combined with Gemfibrozil.
Guanabenz Guanabenz The metabolism of Ramelteon can be decreased when combined with Guanabenz.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Ramelteon.
Flurbiprofen Flurbiprofen Flurbiprofen may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Amiodarone Amiodarone The metabolism of Ramelteon can be decreased when combined with Amiodarone.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Buspirone Buspirone Buspirone may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Lovastatin Lovastatin The metabolism of Ramelteon can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The serum concentration of Ramelteon can be increased when it is combined with Ciprofloxacin.
Mesalamine Mesalamine Mesalazine may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Diclofenac Diclofenac Diclofenac may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Fluoxetine Fluoxetine Fluoxetine may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The metabolism of Ramelteon can be decreased when combined with Interferon alfa-2b.
Clozapine Clozapine The risk or severity of adverse effects can be increased when Clozapine is combined with Ramelteon.
Estazolam Estazolam The risk or severity of adverse effects can be increased when Ramelteon is combined with Estazolam.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Ramelteon.
Ofloxacin Ofloxacin The metabolism of Ramelteon can be decreased when combined with Ofloxacin.
Didanosine Didanosine Didanosine may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Pentostatin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Etodolac Etodolac Etodolac may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Felodipine Felodipine The metabolism of Ramelteon can be decreased when combined with Felodipine.
Fosinopril Fosinopril Fosinopril may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Nabumetone Nabumetone Nabumetone may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Simvastatin Simvastatin The metabolism of Ramelteon can be decreased when combined with Simvastatin.
Teniposide Injection Teniposide Injection The metabolism of Ramelteon can be decreased when combined with Teniposide.
Lisinopril Lisinopril Lisinopril may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Atovaquone Atovaquone The metabolism of Ramelteon can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Ramelteon can be increased when combined with Rifabutin.
Bisoprolol Bisoprolol Bisoprolol may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Zolpidem Zolpidem Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin Doxazosin The metabolism of Ramelteon can be decreased when combined with Doxazosin.
Isradipine Isradipine Isradipine may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Omeprazole Omeprazole The metabolism of Ramelteon can be decreased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Ramelteon can be decreased when combined with Cisapride.
Gabapentin Gabapentin The risk or severity of adverse effects can be increased when Ramelteon is combined with Gabapentin.
Fluvastatin Fluvastatin The metabolism of Ramelteon can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The risk or severity of adverse effects can be increased when Venlafaxine is combined with Ramelteon.
Fluvoxamine Fluvoxamine The serum concentration of Ramelteon can be increased when it is combined with Fluvoxamine.
Nefazodone Nefazodone The risk or severity of adverse effects can be increased when Nefazodone is combined with Ramelteon.
Lamotrigine Lamotrigine The risk or severity of adverse effects can be increased when Lamotrigine is combined with Ramelteon.
Losartan Losartan The metabolism of Ramelteon can be decreased when combined with Losartan.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Tramadol Tramadol The risk or severity of CNS depression can be increased when Ramelteon is combined with Tramadol.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Lansoprazole Lansoprazole The metabolism of Ramelteon can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection Ramelteon may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Nicardipine Nicardipine The metabolism of Ramelteon can be decreased when combined with Nicardipine.
Bupropion Bupropion The risk or severity of adverse effects can be increased when Ramelteon is combined with Bupropion.
Ticlopidine Ticlopidine The metabolism of Ramelteon can be decreased when combined with Ticlopidine.
Metformin Metformin Metformin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Nisoldipine Nisoldipine Nisoldipine may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Lamivudine Lamivudine Lamivudine may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Riluzole Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Ramelteon.
Acarbose Acarbose Acarbose may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Glimepiride Glimepiride The metabolism of Ramelteon can be decreased when combined with Glimepiride.
Gemcitabine Injection Gemcitabine Injection Gemcitabine may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Ritonavir Ritonavir The serum concentration of Ramelteon can be increased when it is combined with Ritonavir.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Meropenem Injection Meropenem Injection Meropenem may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Ramelteon.
Zafirlukast Zafirlukast The serum concentration of Ramelteon can be increased when it is combined with Zafirlukast.
Fosfomycin Fosfomycin Fosfomycin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Mirtazapine Mirtazapine Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Topiramate Topiramate The risk or severity of adverse effects can be increased when Topiramate is combined with Ramelteon.
Zileuton Zileuton The metabolism of Ramelteon can be decreased when combined with Zileuton.
Valsartan Valsartan The metabolism of Ramelteon can be decreased when combined with Valsartan.
Insulin Lispro Injection Insulin Lispro Injection The metabolism of Ramelteon can be increased when combined with Insulin lispro.
Pramipexole Pramipexole Ramelteon may increase the sedative activities of Pramipexole.
Donepezil Donepezil The risk or severity of adverse effects can be increased when Donepezil is combined with Ramelteon.
Nelfinavir Nelfinavir The metabolism of Ramelteon can be decreased when combined with Nelfinavir.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Ramelteon.
Nilutamide Nilutamide The metabolism of Ramelteon can be decreased when combined with Nilutamide.
Flutamide Flutamide The metabolism of Ramelteon can be decreased when combined with Flutamide.
Selegiline Selegiline The metabolism of Ramelteon can be decreased when combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Ramelteon can be decreased when combined with Bicalutamide.
Sertraline Sertraline The risk or severity of adverse effects can be increased when Ramelteon is combined with Sertraline.
Propafenone Propafenone The metabolism of Ramelteon can be decreased when combined with Propafenone.
Letrozole Letrozole The metabolism of Ramelteon can be decreased when combined with Letrozole.
Irbesartan Irbesartan The metabolism of Irbesartan can be decreased when combined with Ramelteon.
Tamsulosin Tamsulosin Tamsulosin may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Ropinirole Ropinirole Ramelteon may increase the sedative activities of Ropinirole.
Quetiapine Quetiapine Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Cetirizine Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Ramelteon.
Paroxetine Paroxetine The risk or severity of adverse effects can be increased when Ramelteon is combined with Paroxetine.
Tolcapone Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Ramelteon.
Citalopram Citalopram The risk or severity of adverse effects can be increased when Ramelteon is combined with Citalopram.
Capecitabine Capecitabine The metabolism of Ramelteon can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Ramelteon can be decreased when combined with Efavirenz.
Abacavir Abacavir Ramelteon may decrease the excretion rate of Abacavir which could result in a higher serum level.
Sildenafil Sildenafil The metabolism of Ramelteon can be decreased when combined with Sildenafil.
Celecoxib Celecoxib Celecoxib may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Rosiglitazone Rosiglitazone The metabolism of Ramelteon can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Tolterodine.
Thalidomide Thalidomide Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Nateglinide Nateglinide Nateglinide may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Levetiracetam Levetiracetam The risk or severity of adverse effects can be increased when Ramelteon is combined with Levetiracetam.
Rabeprazole Rabeprazole The metabolism of Ramelteon can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Ramelteon can be decreased when combined with Terbinafine.

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