Tasimelteon

Generic name: Pronounced as (tas'' i mel' tee on)
Brand names
  • Hetlioz®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 05/15/2021

Tasimelteon is used to treat non-24-hour sleep-wake disorder (non-24; a condition that occurs mainly in people who are blind in which the body's natural clock is out of sync with the normal day-night cycle and causes a disrupted sleep schedule) in adults. It is also used to treat nighttime sleep problems in adults and children 3 years of age and older with Smith-Magenis Syndrome (SMS; a developmental disorder). Tasimelteon is in a class of medications called melatonin receptor agonists. It works similarly to melatonin, a natural substance in the brain that is needed for sleep.

Tasimelteon comes as a capsule and as an suspension to take by mouth. It is usually taken without food once a day, 1 hour before bedtime. Take tasimelteon at the same time every night. If you or your child are unable to take tasimelteon around the same time on a given night, skip that dose and take the next dose as scheduled. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tasimelteon exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not open, crush, or chew them.

If you or your child are taking the suspension, follow these steps to prepare and measure the dose:

  1. Remove the tasimelteon bottle, bottle adapter, and oral dosing syringe from the carton.

  2. Shake the bottle up and down for at least 30 seconds to mix the medication evenly before each administration.

  3. Press down on the child-resistant cap and twist it counterclockwise to open the bottle; do not discard the cap.

  4. Before you open the tasimelteon bottle for the first time, remove the seal from bottle and insert the press-in bottle adapter into the bottle. Press on the bottle adapter until it is even with the top of the bottle; after the bottle adapter is in place, do not remove it. Then, replace the cap by turning clockwise and shake well again for 30 seconds.

  5. Push the plunger of the oral dosing syringe completely down. Insert the oral dosing syringe into the opening of the press-in bottle adapter as far as it will go.

  6. With the oral dosing syringe in the bottle adapter, carefully turn the bottle upside down. Pull the plunger back to withdraw the amount of suspension prescribed by the doctor. If you are not sure how to correctly measure the dose, ask your doctor or pharmacist. If you see more than a few air bubbles in the oral dosing syringe, fully push in the plunger so that the liquid flows back into the bottle until the air bubbles are mostly gone.

  7. Leave the oral dosing syringe in the bottle adapter and turn the bottle upright. Carefully remove the oral dosing syringe from the bottle adapter. Replace the child-resistant cap securely.

  8. Remove the dosing dispenser and slowly squirt the suspension directly into your mouth or your child's mouth and toward the inside of their cheek. Slowly push the plunger all the way in to give the entire dose. Make sure the child has time to swallow the medication.

  9. Remove the plunger from the barrel of the oral dosing syringe. Rinse the oral dosing syringe barrel and plunger with water and when dry, put the plunger back into the oral dosing syringe. Do not wash the oral dosing syringe in the dishwasher.

  10. Do not discard the oral dosing syringe. Always use the oral dosing syringe that comes with tasimelteon to measure your child's dose.

  11. Refrigerate the suspension after each use.

You may become sleepy soon after you take tasimelteon. After you take tasimelteon, you should complete any necessary bedtime preparations and go to bed. Do not plan any other activities for this time.

Tasimelteon controls certain sleep disorders, but does not cure them. It may take several weeks or months before you feel the full benefit of tasimelteon. Continue to take tasimelteon even if you feel well. Do not stop taking tasimelteon without talking to your doctor.

Tasimelteon is not available in pharmacies. You can only get tasimelteon through the mail from a specialty pharmacy. Ask your doctor if you have any questions about receiving your medication.

Tasimelteon capsules and suspension may not be able to be substituted for one another. Ask your pharmacist if you have any questions about the type of tasimelteon product your doctor has prescribed.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking tasimelteon,

  • tell your doctor and pharmacist if you are allergic to tasimelteon, any other medications, or any of the ingredients in tasimelteon capsules and suspension. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: beta blockers such as acebutolol, atenolol (Tenormin), bisoprolol (Zebeta, in Ziac), carvedilol (Coreg), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), nebivolol (Bystolic), and propranolol (Inderal); fluvoxamine (Luvox); ketoconazole (Nizoral); and rifampin (Rifadin, Rifamate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with tasimelteon, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor if you have or have ever had liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking tasimelteon, call your doctor.

  • you should know that tasimelteon may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.

  • ask your doctor about the safe use of alcoholic beverages while you are taking tasimelteon. Alcohol can make the side effects from tasimelteon worse.

  • tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this medication.

Unless your doctor tells you otherwise, continue your normal diet.

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Tasimelteon may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • headache

    • nightmares or unusual dreams

    • fever or painful, difficult, or frequent urination

    • fever, cough, shortness of breath, or other signs of infection

  • Tasimelteon may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom). Refrigerate the suspension. After opening the suspension bottle, discard any unused liquid medication after 5 weeks (for the 48 mL bottle) and after 8 weeks (for the 158 mL bottle).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The metabolism of Tasimelteon can be decreased when combined with Moxifloxacin.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The metabolism of Tasimelteon can be increased when combined with Insulin glargine.
Leflunomide Leflunomide The serum concentration of Tasimelteon can be decreased when it is combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Tasimelteon can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Tasimelteon can be decreased when combined with Nevirapine.
Dolasetron Dolasetron The risk or severity of adverse effects can be increased when Dolasetron is combined with Tasimelteon.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Tasimelteon.
Anagrelide Anagrelide The metabolism of Tasimelteon can be decreased when combined with Anagrelide.
Cilostazol Cilostazol The metabolism of Tasimelteon can be decreased when combined with Cilostazol.
Clopidogrel Clopidogrel The metabolism of Tasimelteon can be decreased when combined with Clopidogrel.
Diphenoxylate Diphenoxylate The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Tasimelteon.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Tasimelteon can be decreased when combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The metabolism of Tasimelteon can be decreased when combined with Conjugated estrogens.
Fenofibrate Fenofibrate The metabolism of Tasimelteon can be decreased when combined with Fenofibrate.
Guanfacine Guanfacine The risk or severity of adverse effects can be increased when Guanfacine is combined with Tasimelteon.
Magnesium Hydroxide Magnesium Hydroxide Tasimelteon may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Methylergonovine Methylergonovine The metabolism of Tasimelteon can be decreased when combined with Methylergometrine.
Mycophenolate Mycophenolate Mycophenolic acid may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Naratriptan Naratriptan The risk or severity of adverse effects can be increased when Naratriptan is combined with Tasimelteon.
Olsalazine Olsalazine Olsalazine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Paregoric Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Tasimelteon.
Pentazocine Pentazocine The risk or severity of adverse effects can be increased when Pentazocine is combined with Tasimelteon.
Potassium Potassium Potassium cation may increase the excretion rate of Tasimelteon which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone Prednisone may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Ranitidine Ranitidine The metabolism of Tasimelteon can be decreased when combined with Ranitidine.
Reserpine Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Tasimelteon.
Rizatriptan Rizatriptan The risk or severity of adverse effects can be increased when Rizatriptan is combined with Tasimelteon.
Sumatriptan Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Tasimelteon.
Tacrolimus Tacrolimus The metabolism of Tacrolimus can be decreased when combined with Tasimelteon.
Tizanidine Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Tasimelteon.
Triamcinolone Triamcinolone The metabolism of Tasimelteon can be increased when combined with Triamcinolone.
Zolmitriptan Zolmitriptan The metabolism of Tasimelteon can be decreased when combined with Zolmitriptan.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection The metabolism of Tasimelteon can be decreased when combined with Doxycycline.
Famotidine Injection Famotidine Injection The metabolism of Tasimelteon can be decreased when combined with Famotidine.
Fluconazole Injection Fluconazole Injection The metabolism of Tasimelteon can be decreased when combined with Fluconazole.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Tasimelteon.
Interferon Beta-1b Injection Interferon Beta-1b Injection The metabolism of Tasimelteon can be decreased when combined with Interferon beta-1b.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The metabolism of Tasimelteon can be decreased when combined with Interferon gamma-1b.
Levofloxacin Injection Levofloxacin Injection The metabolism of Tasimelteon can be decreased when combined with Levofloxacin.
Meperidine Injection Meperidine Injection The risk or severity of adverse effects can be increased when Meperidine is combined with Tasimelteon.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Tasimelteon can be increased when combined with Methylprednisolone.
Metoclopramide Injection Metoclopramide Injection The risk or severity of sedation can be increased when Metoclopramide is combined with Tasimelteon.
Metronidazole Injection Metronidazole Injection The metabolism of Tasimelteon can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Tasimelteon.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Tasimelteon may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Altretamine Altretamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Tasimelteon.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Tasimelteon.
Ondansetron Ondansetron The metabolism of Tasimelteon can be decreased when combined with Ondansetron.
Granisetron Granisetron The risk or severity of adverse effects can be increased when Granisetron is combined with Tasimelteon.
Torsemide Torsemide Torasemide may increase the excretion rate of Tasimelteon which could result in a lower serum level and potentially a reduction in efficacy.
Olanzapine Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Tasimelteon.
Alosetron Alosetron The metabolism of Tasimelteon can be decreased when combined with Alosetron.
Dofetilide Dofetilide The metabolism of Dofetilide can be decreased when combined with Tasimelteon.
Entacapone Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Tasimelteon.
Meloxicam Meloxicam Meloxicam may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Orlistat Orlistat The metabolism of Tasimelteon can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Tasimelteon can be increased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Temozolomide Temozolomide Temozolomide may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Zaleplon Zaleplon The risk or severity of adverse effects can be increased when Zaleplon is combined with Tasimelteon.
Anakinra Anakinra The metabolism of Tasimelteon can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of adverse effects can be increased when Desloratadine is combined with Tasimelteon.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Tasimelteon.
Trimipramine Trimipramine The risk or severity of adverse effects can be increased when Trimipramine is combined with Tasimelteon.
Etanercept Injection Etanercept Injection The metabolism of Tasimelteon can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Modafinil Modafinil The metabolism of Tasimelteon can be increased when combined with Modafinil.
Perindopril Perindopril Perindopril may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Tasimelteon.
Epinephrine Injection Epinephrine Injection The metabolism of Tasimelteon can be decreased when combined with Epinephrine.
Eplerenone Eplerenone Eplerenone may increase the excretion rate of Tasimelteon which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram Escitalopram The risk or severity of adverse effects can be increased when Tasimelteon is combined with Escitalopram.
Zonisamide Zonisamide The risk or severity of adverse effects can be increased when Zonisamide is combined with Tasimelteon.
Adalimumab Injection Adalimumab Injection The metabolism of Tasimelteon can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The risk or severity of adverse effects can be increased when Aripiprazole is combined with Tasimelteon.
Atomoxetine Atomoxetine The risk or severity of adverse effects can be increased when Atomoxetine is combined with Tasimelteon.
Dexmethylphenidate Dexmethylphenidate The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with Tasimelteon.
Atazanavir Atazanavir The metabolism of Tasimelteon can be decreased when combined with Atazanavir.
Almotriptan Almotriptan The risk or severity of adverse effects can be increased when Almotriptan is combined with Tasimelteon.
Eletriptan Eletriptan The risk or severity of adverse effects can be increased when Eletriptan is combined with Tasimelteon.
Mefloquine Mefloquine The metabolism of Tasimelteon can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Tasimelteon can be decreased when combined with Rosuvastatin.
Aprepitant Aprepitant The metabolism of Tasimelteon can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine Emtricitabine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Interferon Beta-1a Subcutaneous Injection Interferon Beta-1a Subcutaneous Injection The metabolism of Tasimelteon can be decreased when combined with Interferon beta-1a.
Memantine Memantine Memantine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Tegaserod Tegaserod The metabolism of Tasimelteon can be decreased when combined with Tegaserod.
Tadalafil Tadalafil Tadalafil may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Frovatriptan Frovatriptan The metabolism of Tasimelteon can be decreased when combined with Frovatriptan.
Gemifloxacin Gemifloxacin The metabolism of Tasimelteon can be decreased when combined with Gemifloxacin.
Progesterone Progesterone The metabolism of Tasimelteon can be increased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Tasimelteon.
Infliximab Injection Infliximab Injection The metabolism of Tasimelteon can be increased when combined with Infliximab.
Protriptyline Protriptyline The risk or severity of adverse effects can be increased when Protriptyline is combined with Tasimelteon.
Rifaximin Rifaximin The metabolism of Tasimelteon can be increased when combined with Rifaximin.
Duloxetine Duloxetine The risk or severity of adverse effects can be increased when Tasimelteon is combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Tasimelteon can be decreased when combined with Norethisterone.
Tinidazole Tinidazole Tinidazole may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Trospium Trospium Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan Bosentan The metabolism of Tasimelteon can be increased when combined with Bosentan.
Cefditoren Cefditoren Cefdinir may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Cinacalcet Cinacalcet The metabolism of Tasimelteon can be decreased when combined with Cinacalcet.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Erlotinib Erlotinib The metabolism of Tasimelteon can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The risk or severity of CNS depression can be increased when Tasimelteon is combined with Eszopiclone.
Ganciclovir Ganciclovir Ganciclovir may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Ribavirin Ribavirin Ribavirin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Solifenacin Solifenacin Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Valganciclovir Valganciclovir Valganciclovir may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Voriconazole Voriconazole The metabolism of Tasimelteon can be decreased when combined with Voriconazole.
Adefovir Adefovir Adefovir may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Tasimelteon.
Entecavir Entecavir The metabolism of Tasimelteon can be decreased when combined with Entecavir.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The metabolism of Tasimelteon can be decreased when combined with Peginterferon alfa-2a.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The serum concentration of Tasimelteon can be increased when it is combined with Peginterferon alfa-2b.
Sodium Oxybate Sodium Oxybate Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Isocarboxazid Isocarboxazid The risk or severity of adverse effects can be increased when Isocarboxazid is combined with Tasimelteon.
Ramelteon Ramelteon The risk or severity of adverse effects can be increased when Ramelteon is combined with Tasimelteon.
Darifenacin Darifenacin Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Darifenacin.
Fentanyl Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Tasimelteon.
Pregabalin Pregabalin The therapeutic efficacy of Tasimelteon can be increased when used in combination with Pregabalin.
Deferasirox Deferasirox The serum concentration of Tasimelteon can be increased when it is combined with Deferasirox.
Phenylephrine Phenylephrine The metabolism of Tasimelteon can be increased when combined with Phenylephrine.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Tasimelteon.
Felbamate Felbamate The risk or severity of adverse effects can be increased when Felbamate is combined with Tasimelteon.
Ranolazine Ranolazine Ranolazine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Abatacept Injection Abatacept Injection The metabolism of Tasimelteon can be increased when combined with Abatacept.
Rasagiline Rasagiline The risk or severity of adverse effects can be increased when Rasagiline is combined with Tasimelteon.
Imatinib Imatinib The metabolism of Tasimelteon can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin Sitagliptin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Varenicline Varenicline Varenicline may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Gefitinib Gefitinib The metabolism of Tasimelteon can be decreased when combined with Gefitinib.
Albuterol Albuterol Salbutamol may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Paliperidone Paliperidone The risk or severity of adverse effects can be increased when Paliperidone is combined with Tasimelteon.
Bortezomib Bortezomib The metabolism of Tasimelteon can be decreased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection Clofarabine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The metabolism of Tasimelteon can be increased when combined with Insulin glulisine.
Lubiprostone Lubiprostone Lubiprostone may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Posaconazole Posaconazole The metabolism of Tasimelteon can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Tasimelteon can be decreased when combined with Primaquine.
Darunavir Darunavir The metabolism of Darunavir can be decreased when combined with Tasimelteon.
Pemetrexed Injection Pemetrexed Injection Tasimelteon may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dimenhydrinate Dimenhydrinate The risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Tasimelteon.
Nabilone Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.
Sorafenib Sorafenib The metabolism of Tasimelteon can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Tasimelteon can be decreased when combined with Sunitinib.
Dronabinol Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.
Lapatinib Lapatinib The metabolism of Tasimelteon can be decreased when combined with Lapatinib.
Levocetirizine Levocetirizine The risk or severity of adverse effects can be increased when Levocetirizine is combined with Tasimelteon.
Pegaptanib Injection Pegaptanib Injection Pegaptanib may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Tasimelteon.
Mexiletine Mexiletine The metabolism of Tasimelteon can be decreased when combined with Mexiletine.
Armodafinil Armodafinil The metabolism of Tasimelteon can be increased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection Azacitidine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Ivermectin Ivermectin The metabolism of Tasimelteon can be increased when combined with Ivermectin.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Tasimelteon.
Lenalidomide Lenalidomide Lenalidomide may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Nilotinib Nilotinib The metabolism of Tasimelteon can be decreased when combined with Nilotinib.
Bexarotene Bexarotene The metabolism of Tasimelteon can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Tasimelteon can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Tasimelteon can be decreased when combined with Chloramphenicol.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Tasimelteon.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Tasimelteon.
Doripenem Injection Doripenem Injection Doripenem may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Etravirine Etravirine The metabolism of Tasimelteon can be increased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection Arsenic trioxide may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Tasimelteon can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The risk or severity of adverse effects can be increased when Tasimelteon is combined with Desvenlafaxine.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Bendamustine Injection Bendamustine Injection The metabolism of Tasimelteon can be decreased when combined with Bendamustine.
Pilocarpine Pilocarpine The metabolism of Tasimelteon can be decreased when combined with Pilocarpine.
Flecainide Flecainide The metabolism of Tasimelteon can be decreased when combined with Flecainide.
Certolizumab Injection Certolizumab Injection The metabolism of Tasimelteon can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Tasimelteon.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Tasimelteon.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Praziquantel Praziquantel The metabolism of Tasimelteon can be decreased when combined with Praziquantel.
Mitotane Mitotane The metabolism of Tasimelteon can be increased when combined with Mitotane.
Methylnaltrexone Injection Methylnaltrexone Injection Methylnaltrexone may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Rufinamide Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Tasimelteon.
Midazolam Midazolam The risk or severity of adverse effects can be increased when Midazolam is combined with Tasimelteon.
Dexrazoxane Injection Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Eltrombopag Eltrombopag The metabolism of Tasimelteon can be decreased when combined with Eltrombopag.
Milnacipran Milnacipran The risk or severity of adverse effects can be increased when Tasimelteon is combined with Milnacipran.
Plerixafor Injection Plerixafor Injection Plerixafor may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Fesoterodine Fesoterodine Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Betaxolol Betaxolol The metabolism of Tasimelteon can be decreased when combined with Betaxolol.
Iloperidone Iloperidone The risk or severity of adverse effects can be increased when Iloperidone is combined with Tasimelteon.
Prasugrel Prasugrel Prasugrel may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Lacosamide Lacosamide The risk or severity of adverse effects can be increased when Lacosamide is combined with Tasimelteon.
Everolimus Everolimus The metabolism of Everolimus can be decreased when combined with Tasimelteon.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Tasimelteon can be decreased when combined with Tolvaptan.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Tasimelteon.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Tasimelteon.
Pralatrexate Injection Pralatrexate Injection Pralatrexate may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Tasimelteon.
Saxagliptin Saxagliptin Saxagliptin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Telavancin Injection Telavancin Injection Telavancin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Tasimelteon.
Tapentadol Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.
Topotecan Topotecan The metabolism of Tasimelteon can be increased when combined with Topotecan.
Golimumab Injection Golimumab Injection The metabolism of Tasimelteon can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Tasimelteon can be decreased when combined with Pazopanib.
Asenapine Asenapine The risk or severity of adverse effects can be increased when Asenapine is combined with Tasimelteon.
Vigabatrin Vigabatrin The risk or severity of adverse effects can be increased when Vigabatrin is combined with Tasimelteon.
Albendazole Albendazole The metabolism of Tasimelteon can be decreased when combined with Albendazole.
Oxymorphone Oxymorphone The risk or severity of adverse effects can be increased when Oxymorphone is combined with Tasimelteon.
Tocilizumab Injection Tocilizumab Injection The metabolism of Tasimelteon can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine Dalfampridine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Tasimelteon.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Tasimelteon.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Lurasidone Lurasidone The risk or severity of adverse effects can be increased when Lurasidone is combined with Tasimelteon.
Acetaminophen Injection Acetaminophen Injection The metabolism of Tasimelteon can be increased when combined with Acetaminophen.
Vilazodone Vilazodone The risk or severity of adverse effects can be increased when Vilazodone is combined with Tasimelteon.
Ipilimumab Injection Ipilimumab Injection Ipilimumab may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Tasimelteon can be decreased when combined with Aldesleukin.
Terbutaline Injection Terbutaline Injection Terbutaline may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be decreased when combined with Tasimelteon.
Roflumilast Roflumilast The metabolism of Tasimelteon can be decreased when combined with Roflumilast.
Linagliptin Linagliptin The metabolism of Tasimelteon can be decreased when combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Tasimelteon can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The metabolism of Tasimelteon can be decreased when combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Tasimelteon can be decreased when combined with Cyclophosphamide.
Abiraterone Abiraterone The serum concentration of Tasimelteon can be increased when it is combined with Abiraterone.
Rivaroxaban Rivaroxaban Rivaroxaban may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Ticagrelor Ticagrelor The metabolism of Tasimelteon can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Tasimelteon can be decreased when combined with Brentuximab vedotin.
Ruxolitinib Ruxolitinib The metabolism of Tasimelteon can be decreased when combined with Ruxolitinib.
Vandetanib Vandetanib The metabolism of Vandetanib can be decreased when combined with Tasimelteon.
Clobazam Clobazam The risk or severity of adverse effects can be increased when Clobazam is combined with Tasimelteon.
Vemurafenib Vemurafenib The serum concentration of Tasimelteon can be increased when it is combined with Vemurafenib.
Ivacaftor Ivacaftor The metabolism of Tasimelteon can be decreased when combined with Ivacaftor.
Deferiprone Deferiprone Deferiprone may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Axitinib Axitinib The metabolism of Tasimelteon can be decreased when combined with Axitinib.
Crizotinib Crizotinib The metabolism of Tasimelteon can be decreased when combined with Crizotinib.
Cabergoline Cabergoline The metabolism of Tasimelteon can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Tasimelteon can be decreased when combined with Naloxone.
Fondaparinux Injection Fondaparinux Injection Fondaparinux may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Ezogabine Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Tasimelteon.
Enzalutamide Enzalutamide The metabolism of Tasimelteon can be increased when combined with Enzalutamide.
Mirabegron Mirabegron Mirabegron may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Regorafenib Regorafenib The metabolism of Tasimelteon can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Tasimelteon can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Tasimelteon can be increased when combined with Corticotropin.
Teriflunomide Teriflunomide The serum concentration of Tasimelteon can be decreased when it is combined with Teriflunomide.
Teduglutide Injection Teduglutide Injection Teduglutide may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Alogliptin Alogliptin Alogliptin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Tasimelteon.
Pomalidomide Pomalidomide The metabolism of Tasimelteon can be decreased when combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Tasimelteon can be decreased when combined with Trastuzumab emtansine.
Canagliflozin Canagliflozin Canagliflozin may increase the excretion rate of Tasimelteon which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Tasimelteon which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib Dabrafenib The metabolism of Tasimelteon can be decreased when combined with Dabrafenib.
Trametinib Trametinib The metabolism of Tasimelteon can be increased when combined with Trametinib.
Levomilnacipran Levomilnacipran The risk or severity of adverse effects can be increased when Tasimelteon is combined with Levomilnacipran.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Vortioxetine Vortioxetine The risk or severity of adverse effects can be increased when Vortioxetine is combined with Tasimelteon.
Perampanel Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.
Lomitapide Lomitapide The metabolism of Tasimelteon can be decreased when combined with Lomitapide.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Simeprevir Simeprevir The metabolism of Tasimelteon can be decreased when combined with Simeprevir.
Sofosbuvir Sofosbuvir Sofosbuvir may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Dapagliflozin Dapagliflozin The metabolism of Tasimelteon can be decreased when combined with Dapagliflozin.
Apremilast Apremilast The metabolism of Tasimelteon can be increased when combined with Apremilast.
Droxidopa Droxidopa Droxidopa may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Ceritinib Ceritinib The metabolism of Tasimelteon can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Tasimelteon can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The risk or severity of adverse effects can be increased when Tasimelteon is combined with Eslicarbazepine.
Belinostat Injection Belinostat Injection The metabolism of Tasimelteon can be increased when combined with Belinostat.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Tasimelteon.
Testosterone Injection Testosterone Injection The metabolism of Tasimelteon can be increased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Tasimelteon can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The metabolism of Tasimelteon can be decreased when combined with Vorapaxar.
Hydrocodone Hydrocodone Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Suvorexant Suvorexant Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Edoxaban Edoxaban Tasimelteon may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The metabolism of Tasimelteon can be decreased when combined with Peginterferon beta-1a.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Tasimelteon.
Methamphetamine Methamphetamine The risk or severity of adverse effects can be increased when Metamfetamine is combined with Tasimelteon.
Lanreotide Injection Lanreotide Injection The metabolism of Tasimelteon can be decreased when combined with Lanreotide.
Pirfenidone Pirfenidone The metabolism of Tasimelteon can be decreased when combined with Pirfenidone.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Tasimelteon.
Secukinumab Injection Secukinumab Injection The metabolism of Tasimelteon can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of adverse effects can be increased when Risperidone is combined with Tasimelteon.
Palbociclib Palbociclib The metabolism of Palbociclib can be decreased when combined with Tasimelteon.
Insulin Human Inhalation Insulin Human Inhalation The metabolism of Tasimelteon can be increased when combined with Insulin human.
Lenvatinib Lenvatinib The metabolism of Tasimelteon can be decreased when combined with Lenvatinib.
Panobinostat Panobinostat The metabolism of Panobinostat can be decreased when combined with Tasimelteon.
Haloperidol Injection Haloperidol Injection The risk or severity of CNS depression can be increased when Haloperidol is combined with Tasimelteon.
Amiloride Amiloride Amiloride may increase the excretion rate of Tasimelteon which could result in a lower serum level and potentially a reduction in efficacy.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Tasimelteon can be increased when combined with Isavuconazonium.
Macitentan Macitentan Macitentan may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Tasimelteon.
Flibanserin Flibanserin The risk or severity of adverse effects can be increased when Flibanserin is combined with Tasimelteon.
Prednisolone Prednisolone The metabolism of Tasimelteon can be increased when combined with Prednisolone.
Brexpiprazole Brexpiprazole The risk or severity of adverse effects can be increased when Tasimelteon is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Tasimelteon.
Cariprazine Cariprazine The risk or severity of adverse effects can be increased when Cariprazine is combined with Tasimelteon.
Penicillin G Procaine Injection Penicillin G Procaine Injection Tasimelteon may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The metabolism of Tasimelteon can be increased when combined with Insulin degludec.
Cobimetinib Cobimetinib The metabolism of Tasimelteon can be decreased when combined with Cobimetinib.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Tasimelteon.
Osimertinib Osimertinib The serum concentration of Tasimelteon can be decreased when it is combined with Osimertinib.
Alectinib Alectinib The metabolism of Alectinib can be decreased when combined with Tasimelteon.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Tasimelteon.
Rifapentine Rifapentine The metabolism of Tasimelteon can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Lesinurad can be increased when combined with Tasimelteon.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection The metabolism of Tasimelteon can be increased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The risk or severity of adverse effects can be increased when Brivaracetam is combined with Tasimelteon.
Venetoclax Venetoclax The metabolism of Tasimelteon can be decreased when combined with Venetoclax.
Cobicistat Cobicistat The metabolism of Tasimelteon can be decreased when combined with Cobicistat.
Pimavanserin Pimavanserin The risk or severity of adverse effects can be increased when Pimavanserin is combined with Tasimelteon.
Obeticholic Acid Obeticholic Acid The metabolism of Tasimelteon can be decreased when combined with Obeticholic acid.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Tasimelteon.
Furosemide Injection Furosemide Injection Furosemide may increase the excretion rate of Tasimelteon which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib Rucaparib The metabolism of Rucaparib can be decreased when combined with Tasimelteon.
Lixisenatide Injection Lixisenatide Injection Tasimelteon may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ribociclib Ribociclib The metabolism of Tasimelteon can be decreased when combined with Ribociclib.
Brigatinib Brigatinib The metabolism of Tasimelteon can be decreased when combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Deutetrabenazine Deutetrabenazine The risk or severity of sedation and somnolence can be increased when Tasimelteon is combined with Deutetrabenazine.
Valbenazine Valbenazine Tasimelteon may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort Deflazacort The metabolism of Tasimelteon can be increased when combined with Deflazacort.
Safinamide Safinamide The metabolism of Tasimelteon can be decreased when combined with Safinamide.
Naldemedine Naldemedine Tasimelteon may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Sarilumab Injection Sarilumab Injection The metabolism of Tasimelteon can be increased when combined with Sarilumab.
Midostaurin Midostaurin The serum concentration of Tasimelteon can be increased when it is combined with Midostaurin.
Neratinib Neratinib The metabolism of Neratinib can be decreased when combined with Tasimelteon.
Enasidenib Enasidenib The metabolism of Tasimelteon can be decreased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Tasimelteon can be increased when combined with Fosaprepitant.
Benznidazole Benznidazole Tasimelteon may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Tasimelteon.
Delafloxacin Delafloxacin Tasimelteon may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Tasimelteon.
Acalabrutinib Acalabrutinib The metabolism of Tasimelteon can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Tasimelteon can be decreased when combined with Letermovir.
Tetrabenazine Tetrabenazine The risk or severity of sedation and somnolence can be increased when Tasimelteon is combined with Tetrabenazine.
Ertugliflozin Ertugliflozin Ertugliflozin may increase the excretion rate of Tasimelteon which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection Buprenorphine Injection Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide Apalutamide The metabolism of Tasimelteon can be increased when combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Tasimelteon can be decreased when combined with Fostamatinib.
Baricitinib Baricitinib The metabolism of Baricitinib can be decreased when combined with Tasimelteon.
Lofexidine Lofexidine The therapeutic efficacy of Tasimelteon can be increased when used in combination with Lofexidine.
Plazomicin Injection Plazomicin Injection Tasimelteon may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Binimetinib Binimetinib The metabolism of Binimetinib can be decreased when combined with Tasimelteon.
Ivosidenib Ivosidenib The metabolism of Tasimelteon can be decreased when combined with Ivosidenib.
Cannabidiol Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Tasimelteon.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Tasimelteon.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Tasimelteon.
Stiripentol Stiripentol The metabolism of Tasimelteon can be decreased when combined with Stiripentol.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Tasimelteon.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Tasimelteon.
Rifamycin Rifamycin The metabolism of Tasimelteon can be increased when combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Tasimelteon can be decreased when combined with Prucalopride.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Tasimelteon can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Tasimelteon.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Tasimelteon.
Alpelisib Alpelisib The metabolism of Tasimelteon can be decreased when combined with Alpelisib.
Brexanolone Injection Brexanolone Injection The risk or severity of adverse effects can be increased when Tasimelteon is combined with Brexanolone.
Solriamfetol Solriamfetol The risk or severity of adverse effects can be increased when Tasimelteon is combined with Solriamfetol.
Triclabendazole Triclabendazole The metabolism of Tasimelteon can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The metabolism of Entrectinib can be decreased when combined with Tasimelteon.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Tasimelteon.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Tasimelteon.
Pitolisant Pitolisant The serum concentration of Tasimelteon can be decreased when it is combined with Pitolisant.
Lefamulin Lefamulin The metabolism of Lefamulin can be decreased when combined with Tasimelteon.
Phenytoin Injection Phenytoin Injection The metabolism of Tasimelteon can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Tasimelteon can be increased when combined with Fosphenytoin.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Tasimelteon.
Lumateperone Lumateperone The risk or severity of adverse effects can be increased when Lumateperone is combined with Tasimelteon.
Lasmiditan Lasmiditan The risk or severity of adverse effects can be increased when Tasimelteon is combined with Lasmiditan.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Tasimelteon.
Cenobamate Cenobamate The serum concentration of Tasimelteon can be decreased when it is combined with Cenobamate.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Tasimelteon.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Tasimelteon.
Capmatinib Capmatinib The metabolism of Tasimelteon can be decreased when combined with Capmatinib.
Lemborexant Lemborexant The risk or severity of adverse effects can be increased when Tasimelteon is combined with Lemborexant.
Fenfluramine Fenfluramine The risk or severity of adverse effects can be increased when Fenfluramine is combined with Tasimelteon.
Octreotide Octreotide The metabolism of Tasimelteon can be decreased when combined with Octreotide.
Pralsetinib Pralsetinib The metabolism of Tasimelteon can be increased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Tasimelteon can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Tasimelteon can be decreased when combined with Drospirenone.
Viloxazine Viloxazine The risk or severity of adverse effects can be increased when Tasimelteon is combined with Viloxazine.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Tasimelteon can be increased when combined with Vitamin E.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Tasimelteon.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Indomethacin Indomethacin Indomethacin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid Mefenamic acid may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Naproxen Naproxen Naproxen may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Trazodone Trazodone The risk or severity of adverse effects can be increased when Tasimelteon is combined with Trazodone.
Isotretinoin Isotretinoin Isotretinoin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Floxuridine Floxuridine Floxuridine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Phenobarbital Phenobarbital The metabolism of Tasimelteon can be increased when combined with Phenobarbital.
Metaxalone Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Tasimelteon.
Methotrexate Injection Methotrexate Injection The metabolism of Tasimelteon can be decreased when combined with Methotrexate.
Levorphanol Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Tasimelteon.
Primidone Primidone The metabolism of Tasimelteon can be increased when combined with Primidone.
Methsuximide Methsuximide The risk or severity of adverse effects can be increased when Methsuximide is combined with Tasimelteon.
Diethylpropion Diethylpropion The risk or severity of adverse effects can be increased when Diethylpropion is combined with Tasimelteon.
Chlorpromazine Chlorpromazine The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Tasimelteon.
Diazepam Diazepam The risk or severity of adverse effects can be increased when Diazepam is combined with Tasimelteon.
Oxazepam Oxazepam The risk or severity of adverse effects can be increased when Oxazepam is combined with Tasimelteon.
Flurazepam Flurazepam The risk or severity of adverse effects can be increased when Flurazepam is combined with Tasimelteon.
Clorazepate Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Tasimelteon.
Lorazepam Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Tasimelteon.
Carmustine Carmustine The metabolism of Tasimelteon can be decreased when combined with Carmustine.
Amantadine Amantadine Amantadine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Codeine Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Tasimelteon.
Meprobamate Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Tasimelteon.
Chlordiazepoxide Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Tasimelteon.
Bromocriptine Bromocriptine The risk or severity of adverse effects can be increased when Bromocriptine is combined with Tasimelteon.
Tranylcypromine Tranylcypromine The metabolism of Tasimelteon can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The risk or severity of adverse effects can be increased when Phenelzine is combined with Tasimelteon.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Tasimelteon.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Tasimelteon.
Tetracycline Tetracycline The metabolism of Tasimelteon can be decreased when combined with Tetracycline.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.
Prochlorperazine Prochlorperazine The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Tasimelteon.
Thioridazine Thioridazine The risk or severity of adverse effects can be increased when Thioridazine is combined with Tasimelteon.
Trifluoperazine Trifluoperazine The risk or severity of adverse effects can be increased when Trifluoperazine is combined with Tasimelteon.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Sulfadiazine Sulfadiazine Sulfadiazine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Oxycodone Oxycodone The risk or severity of adverse effects can be increased when Oxycodone is combined with Tasimelteon.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Tasimelteon.
Oxybutynin Oxybutynin The metabolism of Tasimelteon can be decreased when combined with Oxybutynin.
Benztropine Benztropine Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
Maprotiline Maprotiline Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
Ibuprofen Ibuprofen Ibuprofen may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Trihexyphenidyl Trihexyphenidyl Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine Orphenadrine Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine Perphenazine The risk or severity of adverse effects can be increased when Perphenazine is combined with Tasimelteon.
Azathioprine Azathioprine The metabolism of Tasimelteon can be decreased when combined with Azathioprine.
Fluphenazine Fluphenazine The risk or severity of adverse effects can be increased when Fluphenazine is combined with Tasimelteon.
Phentermine Phentermine The metabolism of Tasimelteon can be decreased when combined with Phentermine.
Methylphenidate Methylphenidate Methylphenidate may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Amoxapine Amoxapine Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Hydrocortisone Hydrocortisone The metabolism of Tasimelteon can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Tasimelteon can be decreased when combined with Doxorubicin.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be increased when combined with Tasimelteon.
Molindone Molindone The risk or severity of adverse effects can be increased when Molindone is combined with Tasimelteon.
Methyldopa Methyldopa Methyldopa may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Tasimelteon.
Hydralazine Hydralazine The metabolism of Tasimelteon can be decreased when combined with Hydralazine.
Cimetidine Cimetidine Cimetidine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Warfarin Warfarin The metabolism of Warfarin can be decreased when combined with Tasimelteon.
Clonazepam Clonazepam The risk or severity of adverse effects can be increased when Clonazepam is combined with Tasimelteon.
Loperamide Loperamide The metabolism of Tasimelteon can be decreased when combined with Loperamide.
Promethazine Promethazine The risk or severity of adverse effects can be increased when Promethazine is combined with Tasimelteon.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Daunorubicin Daunorubicin The metabolism of Tasimelteon can be decreased when combined with Daunorubicin.
Nitrofurantoin Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Tasimelteon can be increased when combined with Griseofulvin.
Digoxin Digoxin Tasimelteon may decrease the excretion rate of Digoxin which could result in a higher serum level.
Loxapine Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Tasimelteon.
Chloroquine Chloroquine Chloroquine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Quinine Quinine The risk or severity of adverse effects can be increased when Quinine is combined with Tasimelteon.
Ethosuximide Ethosuximide The risk or severity of adverse effects can be increased when Ethosuximide is combined with Tasimelteon.
Calcitriol Calcitriol The metabolism of Tasimelteon can be increased when combined with Calcitriol.
Triamterene Triamterene The metabolism of Tasimelteon can be decreased when combined with Triamterene.
Sulfinpyrazone Sulfinpyrazone The metabolism of Tasimelteon can be increased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide Chlorothiazide may increase the excretion rate of Tasimelteon which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone Chlorthalidone Chlorthalidone may increase the excretion rate of Tasimelteon which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone Metolazone Metolazone may increase the excretion rate of Tasimelteon which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide Isosorbide may increase the excretion rate of Tasimelteon which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Tasimelteon.
Desipramine Desipramine The metabolism of Tasimelteon can be decreased when combined with Desipramine.
Amitriptyline Amitriptyline Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Imipramine Imipramine Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Imipramine.
Probenecid Probenecid The metabolism of Tasimelteon can be increased when combined with Probenecid.
Quinidine Quinidine The serum concentration of Tasimelteon can be increased when it is combined with Quinidine.
Procainamide Procainamide Tasimelteon may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid The metabolism of Tasimelteon can be decreased when combined with Isoniazid.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Rifampin Rifampin The metabolism of Rifampicin can be increased when combined with Tasimelteon.
Disopyramide Disopyramide The metabolism of Tasimelteon can be decreased when combined with Disopyramide.
Valproic Acid Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Tasimelteon.
Tamoxifen Tamoxifen The metabolism of Tasimelteon can be decreased when combined with Tamoxifen.
Butabarbital Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Tasimelteon.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Methimazole Methimazole The metabolism of Tasimelteon can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide Chlorpropamide may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Tolbutamide Tolbutamide Tolbutamide may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Tolazamide Tolazamide Tolazamide may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Dextromethorphan Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Tasimelteon.
Cyclobenzaprine Cyclobenzaprine The risk or severity of CNS depression can be increased when Tasimelteon is combined with Cyclobenzaprine.
Niacin Niacin The metabolism of Tasimelteon can be decreased when combined with Niacin.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Tasimelteon.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.
Cyproheptadine Cyproheptadine Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
Clemastine Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Tasimelteon.
Chlorpheniramine Chlorpheniramine The risk or severity of adverse effects can be increased when Chlorpheniramine is combined with Tasimelteon.
Brompheniramine Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Tasimelteon.
Meclizine Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Tasimelteon.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Methyclothiazide Methyclothiazide Methyclothiazide may increase the excretion rate of Tasimelteon which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Dantrolene Dantrolene The risk or severity of adverse effects can be increased when Dantrolene is combined with Tasimelteon.
Chlorzoxazone Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Tasimelteon.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Tasimelteon.
Methocarbamol Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Tasimelteon.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Danazol Danazol The metabolism of Tasimelteon can be decreased when combined with Danazol.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Tasimelteon can be decreased when combined with Propranolol.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Tasimelteon.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Tasimelteon which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Phytonadione Phytonadione Phylloquinone may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Nadolol Nadolol Nadolol may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Butorphanol Injection Butorphanol Injection The risk or severity of adverse effects can be increased when Butorphanol is combined with Tasimelteon.
Nalbuphine Injection Nalbuphine Injection The risk or severity of adverse effects can be increased when Nalbuphine is combined with Tasimelteon.
Allopurinol Allopurinol Allopurinol may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Trimethobenzamide Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Tasimelteon.
Flavoxate Flavoxate Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Fluorouracil Injection Fluorouracil Injection The metabolism of Tasimelteon can be decreased when combined with Fluorouracil.
Colchicine Colchicine The metabolism of Tasimelteon can be increased when combined with Colchicine.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Dacarbazine Dacarbazine The metabolism of Tasimelteon can be decreased when combined with Dacarbazine.
Acetazolamide Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Tasimelteon.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Ketoconazole Ketoconazole The metabolism of Tasimelteon can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel The risk or severity of adverse effects can be increased when Tasimelteon is combined with Pyrantel.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Tasimelteon.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be decreased when combined with Tasimelteon.
Vinblastine Vinblastine The metabolism of Tasimelteon can be decreased when combined with Vinblastine.
Ethacrynic Acid Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Metoprolol Metoprolol The metabolism of Tasimelteon can be decreased when combined with Metoprolol.
Hydroxyzine Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.
Thiothixene Thiothixene The risk or severity of adverse effects can be increased when Thiothixene is combined with Tasimelteon.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Salsalate Salsalate Salsalate may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Alprazolam Alprazolam The risk or severity of adverse effects can be increased when Alprazolam is combined with Tasimelteon.
Temazepam Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Tasimelteon.
Triazolam Triazolam The risk or severity of adverse effects can be increased when Triazolam is combined with Tasimelteon.
Dicyclomine Dicyclomine Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine Hyoscyamine Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline Propantheline Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Trimethoprim Trimethoprim Trimethoprim may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Diltiazem Diltiazem The metabolism of Tasimelteon can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Tasimelteon can be increased when combined with Nifedipine.
Timolol Timolol Timolol may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Verapamil Verapamil The metabolism of Tasimelteon can be decreased when combined with Verapamil.
Pindolol Pindolol The risk or severity of adverse effects can be increased when Pindolol is combined with Tasimelteon.
Cisplatin Injection Cisplatin Injection Tasimelteon may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal Diflunisal may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Piroxicam Piroxicam Piroxicam may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Bumetanide Bumetanide Bumetanide may increase the excretion rate of Tasimelteon which could result in a lower serum level and potentially a reduction in efficacy.
Streptozocin Streptozocin The metabolism of Tasimelteon can be increased when combined with Streptozocin.
Etoposide Etoposide The metabolism of Tasimelteon can be decreased when combined with Etoposide.
Glyburide Glyburide The metabolism of Tasimelteon can be decreased when combined with Glyburide.
Glipizide Glipizide Glipizide may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Indapamide Indapamide Indapamide may increase the excretion rate of Tasimelteon which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin Amoxicillin Amoxicillin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Dicloxacillin Dicloxacillin The metabolism of Tasimelteon can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Tasimelteon can be increased when combined with Nafcillin.
Oxacillin Injection Oxacillin Injection Oxacillin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Pentoxifylline Pentoxifylline The metabolism of Tasimelteon can be decreased when combined with Pentoxifylline.
Pentamidine Injection Pentamidine Injection Pentamidine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Labetalol Labetalol Labetalol may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Auranofin Auranofin Auranofin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Leuprolide may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Gemfibrozil Gemfibrozil The metabolism of Tasimelteon can be decreased when combined with Gemfibrozil.
Guanabenz Guanabenz The metabolism of Tasimelteon can be decreased when combined with Guanabenz.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Tasimelteon.
Flurbiprofen Flurbiprofen Flurbiprofen may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Tasimelteon.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Buspirone Buspirone Buspirone may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Lovastatin Lovastatin The metabolism of Tasimelteon can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The serum concentration of Tasimelteon can be increased when it is combined with Ciprofloxacin.
Mesalamine Mesalamine Mesalazine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Diclofenac Diclofenac Diclofenac may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Fluoxetine Fluoxetine Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Fluoxetine.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The metabolism of Tasimelteon can be decreased when combined with Interferon alfa-2b.
Clozapine Clozapine Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Clozapine.
Estazolam Estazolam The risk or severity of adverse effects can be increased when Estazolam is combined with Tasimelteon.
Ofloxacin Ofloxacin The metabolism of Tasimelteon can be decreased when combined with Ofloxacin.
Didanosine Didanosine Didanosine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Pentostatin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Clarithromycin Clarithromycin The metabolism of Tasimelteon can be decreased when combined with Clarithromycin.
Etodolac Etodolac Etodolac may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Felodipine Felodipine The metabolism of Tasimelteon can be decreased when combined with Felodipine.
Fosinopril Fosinopril Fosinopril may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Nabumetone Nabumetone Nabumetone may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Teniposide Injection Teniposide Injection The metabolism of Tasimelteon can be decreased when combined with Teniposide.
Itraconazole Itraconazole The metabolism of Tasimelteon can be decreased when combined with Itraconazole.
Lisinopril Lisinopril Lisinopril may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Rifabutin Rifabutin The metabolism of Tasimelteon can be increased when combined with Rifabutin.
Bisoprolol Bisoprolol Bisoprolol may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Zolpidem Zolpidem Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin Doxazosin The metabolism of Tasimelteon can be decreased when combined with Doxazosin.
Isradipine Isradipine The metabolism of Tasimelteon can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Tasimelteon can be increased when combined with Omeprazole.
Cisapride Cisapride The risk or severity of adverse effects can be increased when Cisapride is combined with Tasimelteon.
Gabapentin Gabapentin The risk or severity of adverse effects can be increased when Gabapentin is combined with Tasimelteon.
Fluvastatin Fluvastatin The metabolism of Tasimelteon can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The risk or severity of adverse effects can be increased when Venlafaxine is combined with Tasimelteon.
Famciclovir Famciclovir The metabolism of Tasimelteon can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine The serum concentration of Tasimelteon can be increased when it is combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Tasimelteon can be decreased when combined with Nefazodone.
Lamotrigine Lamotrigine The risk or severity of adverse effects can be increased when Lamotrigine is combined with Tasimelteon.
Losartan Losartan The metabolism of Tasimelteon can be decreased when combined with Losartan.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Tramadol Tramadol The risk or severity of CNS depression can be increased when Tasimelteon is combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Tasimelteon.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Lansoprazole Lansoprazole The metabolism of Tasimelteon can be increased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Tasimelteon can be decreased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Tasimelteon can be decreased when combined with Nicardipine.
Bupropion Bupropion The risk or severity of adverse effects can be increased when Bupropion is combined with Tasimelteon.
Ticlopidine Ticlopidine The metabolism of Tasimelteon can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Saquinavir can be decreased when combined with Tasimelteon.
Metformin Metformin Metformin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Nisoldipine Nisoldipine Nisoldipine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Lamivudine Lamivudine Lamivudine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Riluzole Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Tasimelteon.
Acarbose Acarbose Acarbose may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection Gemcitabine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Ritonavir Ritonavir The serum concentration of Tasimelteon can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Tasimelteon can be decreased when combined with Docetaxel.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Meropenem Injection Meropenem Injection Meropenem may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Clomipramine Clomipramine The metabolism of Tasimelteon can be decreased when combined with Clomipramine.
Zafirlukast Zafirlukast The serum concentration of Tasimelteon can be increased when it is combined with Zafirlukast.
Fosfomycin Fosfomycin Fosfomycin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Mirtazapine Mirtazapine Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Topiramate Topiramate The risk or severity of adverse effects can be increased when Topiramate is combined with Tasimelteon.
Zileuton Zileuton The metabolism of Tasimelteon can be decreased when combined with Zileuton.
Insulin Lispro Injection Insulin Lispro Injection The metabolism of Tasimelteon can be increased when combined with Insulin lispro.
Pramipexole Pramipexole Tasimelteon may increase the sedative activities of Pramipexole.
Donepezil Donepezil The risk or severity of adverse effects can be increased when Donepezil is combined with Tasimelteon.
Azithromycin Azithromycin The metabolism of Tasimelteon can be decreased when combined with Azithromycin.
Carvedilol Carvedilol The metabolism of Tasimelteon can be decreased when combined with Carvedilol.
Nilutamide Nilutamide Nilutamide may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Flutamide Flutamide The metabolism of Tasimelteon can be decreased when combined with Flutamide.
Selegiline Selegiline The metabolism of Tasimelteon can be decreased when combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Tasimelteon can be decreased when combined with Bicalutamide.
Sertraline Sertraline The risk or severity of adverse effects can be increased when Tasimelteon is combined with Sertraline.
Propafenone Propafenone The metabolism of Tasimelteon can be decreased when combined with Propafenone.
Raloxifene Raloxifene The metabolism of Tasimelteon can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Tasimelteon can be decreased when combined with Irbesartan.
Tamsulosin Tamsulosin Tamsulosin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Ropinirole Ropinirole Tasimelteon may increase the sedative activities of Ropinirole.
Quetiapine Quetiapine Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Cetirizine Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Tasimelteon.
Paroxetine Paroxetine The risk or severity of adverse effects can be increased when Tasimelteon is combined with Paroxetine.
Tolcapone Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Tasimelteon.
Citalopram Citalopram The risk or severity of adverse effects can be increased when Tasimelteon is combined with Citalopram.
Capecitabine Capecitabine Capecitabine may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Efavirenz Efavirenz The metabolism of Tasimelteon can be decreased when combined with Efavirenz.
Abacavir Abacavir Abacavir may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Celecoxib Celecoxib Celecoxib may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Rosiglitazone Rosiglitazone The metabolism of Tasimelteon can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Tolterodine.
Thalidomide Thalidomide Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Nateglinide Nateglinide Nateglinide may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Levetiracetam Levetiracetam The risk or severity of adverse effects can be increased when Levetiracetam is combined with Tasimelteon.
Rabeprazole Rabeprazole The metabolism of Tasimelteon can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Tasimelteon can be decreased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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