Vismodegib

Generic name: Pronounced as (vis'' moe deg' ib)
Brand names
  • Erivedge®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 11/15/2016

For all patients:

Vismodegib should not be taken by women who are pregnant or who may become pregnant. There is a risk that vismodegib will cause loss of the pregnancy or will cause the baby to be born with birth defects (physical problems that are present at birth).

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with vismodegib and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or visit the manufacturer's web site to obtain the Medication Guide.

Do not donate blood while you are taking vismodegib and for 7 months after your treatment.

Do not share vismodegib with anyone else, even someone who has the same symptoms you have.

Talk to your doctor about the risk(s) of taking vismodegib.

For female patients:

If you can become pregnant, you will need to avoid becoming pregnant during your treatment with vismodegib. You must have a negative pregnancy test within 1 week of the start of your treatment. You must use acceptable forms of birth control during your treatment and for 7 months after your treatment is completed. Your doctor will tell you which forms of birth control are acceptable.

If you think you are pregnant, you miss a menstrual period, or you have sex without using birth control while taking vismodegib or within 7 months after your treatment, call your doctor immediately.

For male patients:

You must use a condom every time you have sexual contact with a female who is pregnant or able to become pregnant while you are taking vismodegib and for 3 months after your treatment. This is required even if you have had a vasectomy (surgery to prevent sperm from leaving your body and causing pregnancy). Tell your doctor immediately if you have had unprotected sex with a woman who can become pregnant or if you think for any reason that your partner is pregnant.

Do not donate semen while you are taking vismodegib and for 3 months after your treatment.

Vismodegib is used to treat basal cell carcinoma (a type of skin cancer) in people with cancer that has spread to other parts of the body. Vismodegib is also used to treat basal cell carcinoma that cannot be treated with surgery or radiation or has come back after surgery. Vismodegib is in a class of medications called hedgehog pathway inhibitors. It works by blocking the action of a protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells and may help shrink tumors.

Vismodegib comes as a capsule to take by mouth. It is usually taken once a day with or without food. To help you remember to take vismodegib, take it at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take vismodegib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not split, chew, or crush them.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking vismodegib,

  • tell your doctor and pharmacist if you are allergic to vismodegib, any other medications, or any of the ingredients in vismodegib capsules. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antacids; certain antibiotics such as azithromycin (Z-Pak, Zithromax), clarithromycin (Biaxin, in Prevpac), and erythromycin (E.E.S., Eryc, Ery-Tab, Erythrocin, PCE); a medication for indigestion, heartburn, or ulcers such as cimetidine (Tagamet), famotidine (Pepcid), and ranitidine (Zantac); and proton-pump inhibitors such as dexlansoprazole (Dexilant), lansoprazole (Prevacid, in Prevpac), omeprazole (Prilosec, Zegerid), pantoprazole (Protonix), and rabeprazole (AcipHex). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with vismodegib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • do not breast-feed while you are taking vismodegib and for 7 months after your treatment.

Unless your doctor tells you otherwise, continue your normal diet.

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Vismodegib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • muscle spasms

    • joint pain

    • tiredness

    • hair loss

    • change in how things taste or loss of taste

    • decreased appetite

    • weight loss

    • nausea

    • vomiting

    • diarrhea

    • constipation

    • missed menstrual periods

  • Vismodegib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor.

Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The metabolism of Repaglinide can be decreased when combined with Vismodegib.
Montelukast Montelukast The metabolism of Montelukast can be decreased when combined with Vismodegib.
Leflunomide Leflunomide Vismodegib may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Delavirdine Delavirdine The metabolism of Vismodegib can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Vismodegib can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Vismodegib.
Candesartan Candesartan The metabolism of Candesartan can be decreased when combined with Vismodegib.
Cilostazol Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Vismodegib.
Clopidogrel Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Vismodegib.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Vismodegib may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate Fenofibrate The metabolism of Vismodegib can be decreased when combined with Fenofibrate.
Paregoric Paregoric The metabolism of Morphine can be decreased when combined with Vismodegib.
Sumatriptan Sumatriptan Vismodegib may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection The metabolism of Vismodegib can be decreased when combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The metabolism of Hydromorphone can be decreased when combined with Vismodegib.
Metronidazole Injection Metronidazole Injection The metabolism of Vismodegib can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The metabolism of Morphine can be decreased when combined with Vismodegib.
Zidovudine Injection Zidovudine Injection Vismodegib may decrease the excretion rate of Zidovudine which could result in a higher serum level.
Ondansetron Ondansetron The metabolism of Ondansetron can be decreased when combined with Vismodegib.
Torsemide Torsemide The metabolism of Torasemide can be decreased when combined with Vismodegib.
Olanzapine Olanzapine The metabolism of Vismodegib can be decreased when combined with Olanzapine.
Alosetron Alosetron The metabolism of Alosetron can be decreased when combined with Vismodegib.
Hydroxychloroquine Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Vismodegib.
Meloxicam Meloxicam The metabolism of Meloxicam can be decreased when combined with Vismodegib.
Pantoprazole Pantoprazole The metabolism of Pantoprazole can be decreased when combined with Vismodegib.
Anakinra Anakinra The metabolism of Vismodegib can be increased when combined with Anakinra.
Trimipramine Trimipramine The metabolism of Trimipramine can be decreased when combined with Vismodegib.
Etanercept Injection Etanercept Injection The metabolism of Vismodegib can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Vismodegib can be decreased when combined with Modafinil.
Epinephrine Injection Epinephrine Injection The metabolism of Vismodegib can be decreased when combined with Epinephrine.
Escitalopram Escitalopram The metabolism of Escitalopram can be decreased when combined with Vismodegib.
Zonisamide Zonisamide The metabolism of Zonisamide can be decreased when combined with Vismodegib.
Adalimumab Injection Adalimumab Injection The metabolism of Vismodegib can be increased when combined with Adalimumab.
Ezetimibe Ezetimibe Vismodegib may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Atazanavir Atazanavir The metabolism of Vismodegib can be decreased when combined with Atazanavir.
Almotriptan Almotriptan The metabolism of Almotriptan can be decreased when combined with Vismodegib.
Eletriptan Eletriptan The metabolism of Eletriptan can be decreased when combined with Vismodegib.
Rosuvastatin Rosuvastatin Vismodegib may decrease the excretion rate of Rosuvastatin which could result in a higher serum level.
Aprepitant Aprepitant The metabolism of Vismodegib can be decreased when combined with Aprepitant.
Tegaserod Tegaserod Vismodegib may decrease the excretion rate of Tegaserod which could result in a higher serum level.
Progesterone Progesterone The metabolism of Vismodegib can be decreased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Vismodegib.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Vismodegib.
Infliximab Injection Infliximab Injection The metabolism of Vismodegib can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Vismodegib can be decreased when combined with Oxandrolone.
Duloxetine Duloxetine The metabolism of Duloxetine can be decreased when combined with Vismodegib.
Bosentan Bosentan The metabolism of Vismodegib can be increased when combined with Bosentan.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Vismodegib.
Eszopiclone Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Vismodegib.
Voriconazole Voriconazole The metabolism of Voriconazole can be decreased when combined with Vismodegib.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Vismodegib can be increased when combined with Peginterferon alfa-2b.
Ramelteon Ramelteon The metabolism of Ramelteon can be decreased when combined with Vismodegib.
Felbamate Felbamate The metabolism of Vismodegib can be decreased when combined with Felbamate.
Abatacept Injection Abatacept Injection The metabolism of Vismodegib can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Vismodegib can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The metabolism of Sitagliptin can be decreased when combined with Vismodegib.
Gefitinib Gefitinib Vismodegib may decrease the excretion rate of Gefitinib which could result in a higher serum level.
Bortezomib Bortezomib The metabolism of Vismodegib can be decreased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection Vismodegib may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Oxaliplatin Injection Oxaliplatin Injection Vismodegib may decrease the excretion rate of Oxaliplatin which could result in a higher serum level.
Nabilone Nabilone The metabolism of Vismodegib can be decreased when combined with Nabilone.
Sorafenib Sorafenib The metabolism of Vismodegib can be decreased when combined with Sorafenib.
Dronabinol Dronabinol The metabolism of Dronabinol can be decreased when combined with Vismodegib.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Vismodegib.
Dasatinib Dasatinib Vismodegib may decrease the excretion rate of Dasatinib which could result in a higher serum level.
Armodafinil Armodafinil The metabolism of Vismodegib can be decreased when combined with Armodafinil.
Ivermectin Ivermectin Vismodegib may decrease the excretion rate of Ivermectin which could result in a higher serum level.
Nilotinib Nilotinib Vismodegib may decrease the excretion rate of Nilotinib which could result in a higher serum level.
Bexarotene Bexarotene The metabolism of Bexarotene can be decreased when combined with Vismodegib.
Etravirine Etravirine The metabolism of Etravirine can be decreased when combined with Vismodegib.
Mitoxantrone Injection Mitoxantrone Injection Vismodegib may decrease the excretion rate of Mitoxantrone which could result in a higher serum level.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Vismodegib.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Vismodegib.
Flecainide Flecainide The metabolism of Vismodegib can be decreased when combined with Flecainide.
Certolizumab Injection Certolizumab Injection The metabolism of Vismodegib can be increased when combined with Certolizumab pegol.
Irinotecan Injection Irinotecan Injection Vismodegib may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Vismodegib.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Vismodegib.
Dexlansoprazole Dexlansoprazole The metabolism of Dexlansoprazole can be decreased when combined with Vismodegib.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Vismodegib.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Vismodegib.
Pralatrexate Injection Pralatrexate Injection Vismodegib may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Vismodegib.
Topotecan Topotecan Vismodegib may decrease the excretion rate of Topotecan which could result in a higher serum level.
Golimumab Injection Golimumab Injection The metabolism of Vismodegib can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Vismodegib.
Pitavastatin Pitavastatin Vismodegib may decrease the excretion rate of Pitavastatin which could result in a higher serum level.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Vismodegib.
Tocilizumab Injection Tocilizumab Injection The metabolism of Vismodegib can be increased when combined with Tocilizumab.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Vismodegib.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Vismodegib.
Telaprevir Telaprevir Vismodegib may decrease the excretion rate of Glecaprevir which could result in a higher serum level.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Vismodegib.
Abiraterone Abiraterone The metabolism of Vismodegib can be decreased when combined with Abiraterone.
Rivaroxaban Rivaroxaban Vismodegib may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor Ticagrelor The metabolism of Vismodegib can be decreased when combined with Ticagrelor.
Clobazam Clobazam The metabolism of Clobazam can be decreased when combined with Vismodegib.
Vemurafenib Vemurafenib Vismodegib may decrease the excretion rate of Vemurafenib which could result in a higher serum level.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Vismodegib.
Enzalutamide Enzalutamide The metabolism of Vismodegib can be increased when combined with Enzalutamide.
Regorafenib Regorafenib The metabolism of Vismodegib can be decreased when combined with Regorafenib.
Teriflunomide Teriflunomide Vismodegib may decrease the excretion rate of Teriflunomide which could result in a higher serum level.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Vismodegib.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Vismodegib.
Apixaban Apixaban Vismodegib may decrease the excretion rate of Apixaban which could result in a higher serum level.
Dabrafenib Dabrafenib The metabolism of Vismodegib can be decreased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Vismodegib.
Dolutegravir Dolutegravir Vismodegib may decrease the excretion rate of Dolutegravir which could result in a higher serum level.
Afatinib Afatinib Vismodegib may decrease the excretion rate of Afatinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Vismodegib.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Vismodegib.
Ketorolac Injection Ketorolac Injection The metabolism of Ketorolac can be decreased when combined with Vismodegib.
Simeprevir Simeprevir Vismodegib may decrease the excretion rate of Simeprevir which could result in a higher serum level.
Sofosbuvir Sofosbuvir Vismodegib may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Vismodegib.
Apremilast Apremilast The metabolism of Vismodegib can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Vismodegib can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Vismodegib can be increased when combined with Siltuximab.
Idelalisib Idelalisib Vismodegib may decrease the excretion rate of Idelalisib which could result in a higher serum level.
Testosterone Injection Testosterone Injection Vismodegib may decrease the excretion rate of Testosterone which could result in a higher serum level.
Oritavancin Injection Oritavancin Injection The metabolism of Vismodegib can be decreased when combined with Oritavancin.
Riociguat Riociguat Vismodegib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Secukinumab Injection Secukinumab Injection The metabolism of Vismodegib can be increased when combined with Secukinumab.
Palbociclib Palbociclib Vismodegib may decrease the excretion rate of Palbociclib which could result in a higher serum level.
Lenvatinib Lenvatinib Vismodegib may decrease the excretion rate of Lenvatinib which could result in a higher serum level.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Vismodegib.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Vismodegib.
Osimertinib Osimertinib Vismodegib may decrease the excretion rate of Osimertinib which could result in a higher serum level.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Vismodegib.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Vismodegib.
Venetoclax Venetoclax Vismodegib may decrease the excretion rate of Venetoclax which could result in a higher serum level.
Selexipag Selexipag The metabolism of Selexipag can be decreased when combined with Vismodegib.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Vismodegib.
Rucaparib Rucaparib Vismodegib may decrease the excretion rate of Rucaparib which could result in a higher serum level.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Vismodegib.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Vismodegib.
Safinamide Safinamide The metabolism of Vismodegib can be decreased when combined with Safinamide.
Midostaurin Midostaurin The metabolism of Vismodegib can be decreased when combined with Midostaurin.
Enasidenib Enasidenib The metabolism of Enasidenib can be decreased when combined with Vismodegib.
Copanlisib Injection Copanlisib Injection Vismodegib may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Delafloxacin Delafloxacin Vismodegib may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib Abemaciclib Vismodegib may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Ertugliflozin Ertugliflozin Vismodegib may decrease the excretion rate of Ertugliflozin which could result in a higher serum level.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Vismodegib.
Apalutamide Apalutamide The metabolism of Vismodegib can be decreased when combined with Apalutamide.
Avatrombopag Avatrombopag The metabolism of Vismodegib can be increased when combined with Avatrombopag.
Lusutrombopag Lusutrombopag Vismodegib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Vismodegib.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Vismodegib.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Vismodegib.
Duvelisib Duvelisib Vismodegib may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Stiripentol Stiripentol The metabolism of Vismodegib can be decreased when combined with Stiripentol.
Talazoparib Talazoparib Vismodegib may decrease the excretion rate of Talazoparib which could result in a higher serum level.
Glasdegib Glasdegib Vismodegib may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Vismodegib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Vismodegib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Vismodegib.
Rifamycin Rifamycin The metabolism of Vismodegib can be decreased when combined with Rifamycin.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Vismodegib can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Vismodegib.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Vismodegib.
Esomeprazole Injection Esomeprazole Injection The metabolism of Esomeprazole can be decreased when combined with Vismodegib.
Alpelisib Alpelisib The serum concentration of Alpelisib can be increased when it is combined with Vismodegib.
Cladribine Cladribine Vismodegib may decrease the excretion rate of Cladribine which could result in a higher serum level.
Darolutamide Darolutamide Vismodegib may decrease the excretion rate of Darolutamide which could result in a higher serum level.
Triclabendazole Triclabendazole The metabolism of Triclabendazole can be decreased when combined with Vismodegib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Vismodegib.
Pitolisant Pitolisant The serum concentration of Vismodegib can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The metabolism of Fedratinib can be decreased when combined with Vismodegib.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Vismodegib.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Vismodegib.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Vismodegib.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Vismodegib.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Vismodegib.
Tazemetostat Tazemetostat Vismodegib may decrease the excretion rate of Tazemetostat which could result in a higher serum level.
Cenobamate Cenobamate The serum concentration of Cenobamate can be decreased when it is combined with Vismodegib.
Ozanimod Ozanimod Vismodegib may decrease the excretion rate of Ozanimod which could result in a higher serum level.
Selumetinib Selumetinib Vismodegib may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Vismodegib.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Vismodegib.
Ripretinib Ripretinib Vismodegib may decrease the excretion rate of Ripretinib which could result in a higher serum level.
Fostemsavir Fostemsavir Vismodegib may decrease the excretion rate of Fostemsavir which could result in a higher serum level.
Pralsetinib Pralsetinib Vismodegib may decrease the excretion rate of Pralsetinib which could result in a higher serum level.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Vismodegib can be decreased when it is combined with Satralizumab.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Vismodegib.
Indomethacin Indomethacin The metabolism of Indomethacin can be decreased when combined with Vismodegib.
Mefenamic Acid Mefenamic Acid The metabolism of Mefenamic acid can be decreased when combined with Vismodegib.
Naproxen Naproxen The metabolism of Naproxen can be decreased when combined with Vismodegib.
Floxuridine Floxuridine The metabolism of Vismodegib can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Vismodegib.
Methotrexate Injection Methotrexate Injection Vismodegib may decrease the excretion rate of Methotrexate which could result in a higher serum level.
Primidone Primidone The metabolism of Primidone can be decreased when combined with Vismodegib.
Methsuximide Methsuximide The metabolism of Methsuximide can be decreased when combined with Vismodegib.
Diazepam Diazepam The metabolism of Diazepam can be decreased when combined with Vismodegib.
Tranylcypromine Tranylcypromine The metabolism of Vismodegib can be decreased when combined with Tranylcypromine.
Thioridazine Thioridazine The metabolism of Thioridazine can be decreased when combined with Vismodegib.
Dapsone Dapsone The metabolism of Dapsone can be decreased when combined with Vismodegib.
Sulfadiazine Sulfadiazine The metabolism of Sulfadiazine can be decreased when combined with Vismodegib.
Methadone Methadone The metabolism of Methadone can be decreased when combined with Vismodegib.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Vismodegib.
Sulfasalazine Sulfasalazine Vismodegib may decrease the excretion rate of Sulfasalazine which could result in a higher serum level.
Doxorubicin Doxorubicin Vismodegib may decrease the excretion rate of Doxorubicin which could result in a higher serum level.
Dactinomycin Dactinomycin Vismodegib may decrease the excretion rate of Dactinomycin which could result in a higher serum level.
Prazosin Prazosin Vismodegib may decrease the excretion rate of Prazosin which could result in a higher serum level.
Cimetidine Cimetidine The metabolism of Vismodegib can be decreased when combined with Cimetidine.
Warfarin Warfarin The metabolism of Vismodegib can be decreased when combined with Warfarin.
Loperamide Loperamide The metabolism of Loperamide can be decreased when combined with Vismodegib.
Promethazine Promethazine The metabolism of Vismodegib can be decreased when combined with Promethazine.
Daunorubicin Daunorubicin Vismodegib may decrease the excretion rate of Daunorubicin which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Vismodegib may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Vismodegib.
Quinine Quinine The metabolism of Quinine can be decreased when combined with Vismodegib.
Sulfinpyrazone Sulfinpyrazone The metabolism of Vismodegib can be decreased when combined with Sulfinpyrazone.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Vismodegib.
Imipramine Imipramine The metabolism of Imipramine can be decreased when combined with Vismodegib.
Probenecid Probenecid The metabolism of Vismodegib can be decreased when combined with Probenecid.
Quinidine Quinidine The metabolism of Vismodegib can be decreased when combined with Quinidine.
Isoniazid Isoniazid The metabolism of Vismodegib can be decreased when combined with Isoniazid.
Valproic Acid Valproic Acid The metabolism of Vismodegib can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Vismodegib.
Methimazole Methimazole The metabolism of Vismodegib can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide The metabolism of Chlorpropamide can be decreased when combined with Vismodegib.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Vismodegib.
Tolazamide Tolazamide The metabolism of Tolazamide can be decreased when combined with Vismodegib.
Dextromethorphan Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Vismodegib.
Carisoprodol Carisoprodol The metabolism of Carisoprodol can be decreased when combined with Vismodegib.
Folic Acid Folic Acid Vismodegib may decrease the excretion rate of Folic acid which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The serum concentration of Propranolol can be increased when it is combined with Vismodegib.
Allopurinol Allopurinol Vismodegib may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Vismodegib.
Vincristine Injection Vincristine Injection Vismodegib may decrease the excretion rate of Vincristine which could result in a higher serum level.
Aspirin Aspirin The metabolism of Acetylsalicylic acid can be decreased when combined with Vismodegib.
Trimethoprim Trimethoprim The metabolism of Trimethoprim can be decreased when combined with Vismodegib.
Diltiazem Diltiazem The metabolism of Diltiazem can be decreased when combined with Vismodegib.
Timolol Timolol The metabolism of Timolol can be decreased when combined with Vismodegib.
Verapamil Verapamil The metabolism of Verapamil can be decreased when combined with Vismodegib.
Cisplatin Injection Cisplatin Injection The metabolism of Vismodegib can be decreased when combined with Cisplatin.
Piroxicam Piroxicam The metabolism of Piroxicam can be decreased when combined with Vismodegib.
Etoposide Etoposide Vismodegib may decrease the excretion rate of Etoposide which could result in a higher serum level.
Glyburide Glyburide Vismodegib may decrease the excretion rate of Glyburide which could result in a higher serum level.
Glipizide Glipizide The metabolism of Glipizide can be decreased when combined with Vismodegib.
Labetalol Labetalol The metabolism of Labetalol can be decreased when combined with Vismodegib.
Gemfibrozil Gemfibrozil The metabolism of Vismodegib can be decreased when combined with Gemfibrozil.
Flurbiprofen Flurbiprofen The metabolism of Flurbiprofen can be decreased when combined with Vismodegib.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Vismodegib.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Vismodegib.
Diclofenac Diclofenac The metabolism of Diclofenac can be decreased when combined with Vismodegib.
Fluoxetine Fluoxetine The metabolism of Vismodegib can be decreased when combined with Fluoxetine.
Clozapine Clozapine The metabolism of Clozapine can be decreased when combined with Vismodegib.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Vismodegib.
Etodolac Etodolac The metabolism of Etodolac can be decreased when combined with Vismodegib.
Felodipine Felodipine The metabolism of Felodipine can be decreased when combined with Vismodegib.
Nabumetone Nabumetone The metabolism of Nabumetone can be decreased when combined with Vismodegib.
Pravastatin Pravastatin Vismodegib may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Simvastatin Simvastatin The metabolism of Vismodegib can be decreased when combined with Simvastatin.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Vismodegib.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be decreased when combined with Vismodegib.
Atovaquone Atovaquone The metabolism of Vismodegib can be decreased when combined with Atovaquone.
Zolpidem Zolpidem The metabolism of Zolpidem can be decreased when combined with Vismodegib.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Vismodegib.
Omeprazole Omeprazole The metabolism of Omeprazole can be decreased when combined with Vismodegib.
Cisapride Cisapride The metabolism of Cisapride can be decreased when combined with Vismodegib.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Vismodegib.
Venlafaxine Venlafaxine The metabolism of Venlafaxine can be decreased when combined with Vismodegib.
Fluvoxamine Fluvoxamine The metabolism of Vismodegib can be decreased when combined with Fluvoxamine.
Losartan Losartan The metabolism of Losartan can be decreased when combined with Vismodegib.
Lansoprazole Lansoprazole The metabolism of Vismodegib can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Vismodegib.
Nicardipine Nicardipine The metabolism of Vismodegib can be decreased when combined with Nicardipine.
Bupropion Bupropion The metabolism of Bupropion can be decreased when combined with Vismodegib.
Ticlopidine Ticlopidine The metabolism of Vismodegib can be decreased when combined with Ticlopidine.
Lamivudine Lamivudine Vismodegib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole Vismodegib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Glimepiride Glimepiride The metabolism of Glimepiride can be decreased when combined with Vismodegib.
Anastrozole Anastrozole The metabolism of Anastrozole can be decreased when combined with Vismodegib.
Ritonavir Ritonavir The serum concentration of Ritonavir can be increased when it is combined with Vismodegib.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Vismodegib.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Vismodegib.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Vismodegib.
Valsartan Valsartan The metabolism of Vismodegib can be decreased when combined with Valsartan.
Donepezil Donepezil The metabolism of Donepezil can be decreased when combined with Vismodegib.
Nelfinavir Nelfinavir The metabolism of Vismodegib can be decreased when combined with Nelfinavir.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Vismodegib.
Nilutamide Nilutamide The metabolism of Vismodegib can be decreased when combined with Nilutamide.
Selegiline Selegiline The metabolism of Selegiline can be decreased when combined with Vismodegib.
Bicalutamide Bicalutamide The metabolism of Vismodegib can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Vismodegib can be decreased when combined with Sertraline.
Raloxifene Raloxifene Vismodegib may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Irbesartan Irbesartan The metabolism of Irbesartan can be decreased when combined with Vismodegib.
Paroxetine Paroxetine The metabolism of Vismodegib can be decreased when combined with Paroxetine.
Tolcapone Tolcapone The metabolism of Vismodegib can be decreased when combined with Tolcapone.
Citalopram Citalopram Vismodegib may increase the QTc-prolonging activities of Citalopram.
Capecitabine Capecitabine The metabolism of Vismodegib can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Vismodegib can be decreased when combined with Efavirenz.
Sildenafil Sildenafil The metabolism of Sildenafil can be decreased when combined with Vismodegib.
Pioglitazone Pioglitazone The metabolism of Pioglitazone can be decreased when combined with Vismodegib.
Celecoxib Celecoxib The metabolism of Celecoxib can be decreased when combined with Vismodegib.
Rosiglitazone Rosiglitazone The metabolism of Rosiglitazone can be decreased when combined with Vismodegib.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Vismodegib.
Thalidomide Thalidomide The metabolism of Thalidomide can be decreased when combined with Vismodegib.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Vismodegib.
Rabeprazole Rabeprazole The metabolism of Rabeprazole can be decreased when combined with Vismodegib.
Terbinafine Terbinafine The metabolism of Terbinafine can be decreased when combined with Vismodegib.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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