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Droxidopa

Droxidopa is an oral medication used to treat dizziness, lightheadedness, and near-fainting caused by neurogenic orthostatic hypotension (low blood pressure when standing) in adults with certain nervous system disorders.

Brand name Northera
Drug class Catecholamines
Rx Form 1
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 16 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 5, 2026
Droxidopa at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Droxidopa (Northera), on the market since about 2014 and available as a generic, is a specialist medicine the body turns into norepinephrine to tighten blood vessels, easing dizziness and near-fainting on standing from nerve-related low blood pressure (neurogenic orthostatic hypotension), as in Parkinson's disease. Most people tolerate it fairly well, noticing mainly headache, dizziness or nausea. The one to watch is its boxed warning for supine hypertension (high blood pressure lying flat, which can raise stroke risk), so sleep with the head of the bed raised and get blood pressure checked as doses rise. Benefit beyond 2 weeks has not been established, so it should be reassessed regularly.

Clinical pearls

  • Take the last dose of the day at least 3 hours before bedtime to lower the chance of high blood pressure overnight.
  • If you take carbidopa/levodopa, tell the prescriber, since carbidopa can raise droxidopa levels and the dose may need adjusting.
  • Avoid linezolid and non-selective MAO inhibitors; midodrine, ephedrine and triptans also stack up and can push blood pressure dangerously high.
  • A severe, pounding headache while lying flat can signal dangerously high blood pressure, so call your prescriber right away.
How we write & review this content — our editorial policy →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

Droxidopa can raise your blood pressure to dangerous levels when you are lying flat (supine hypertension). This is serious because sustained high blood pressure in this position can increase the risk of stroke and other cardiovascular events. Your blood pressure must be checked before you start treatment, each time your dose goes up, and on a regular basis throughout therapy — and it should be measured while your head is elevated, not lying completely flat. To reduce this risk, keep the head of your bed raised while you sleep and always take your last daily dose at least 3 hours before bedtime. If your blood pressure stays too high despite these measures, your doctor will lower your dose or stop the medication.

Read the full warning on DailyMed →
How you get itPrescription only
Comes asCapsule
Earliest FDA record2014
Companies listing it with the FDA15
FDA label last updatedJul 1, 2019
FDA’s strongest warning (boxed)Yes, read the warning

Patient information guide A plain-language walkthrough of Droxidopa, written from its FDA label.

What Droxidopa is used for

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Droxidopa is used to reduce the dizziness, lightheadedness, and near-fainting that occur when people with certain neurological conditions stand up — a problem called neurogenic orthostatic hypotension (nOH).

  • Northera (brand-name droxidopa capsule) is FDA-approved for adults with symptomatic nOH caused by Parkinson's disease, multiple system atrophy, pure autonomic failure, dopamine beta-hydroxylase deficiency, or non-diabetic autonomic neuropathy
  • Droxidopa capsules (generic) are approved for the same set of conditions and the same adult population
  • Both products are approved for the symptoms of dizziness, lightheadedness, and the feeling of nearly blacking out when standing
  • The evidence for effectiveness beyond 2 weeks has not been firmly established; continued use should be assessed periodically by your prescriber

How Droxidopa works

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Droxidopa is a synthetic amino acid that the body converts directly into norepinephrine — the same chemical the nervous system normally uses to tighten blood vessels when you stand up. In people with neurogenic orthostatic hypotension, this automatic response is impaired. By supplying a source that becomes norepinephrine, droxidopa causes the arteries and veins to constrict (squeeze), raising blood pressure enough to prevent that sudden drop — and the dizziness that comes with it. The exact mechanism in nOH is not fully understood, but the effects are believed to come from norepinephrine itself, not from droxidopa or its other breakdown products.

Droxidopa dosage

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Droxidopa capsules are taken three times a day by mouth — in the morning when you wake up, around midday, and in the late afternoon at least 3 hours before bed (to lower the chance of high blood pressure overnight). Swallow the capsule whole. Choose to take it consistently with food or without food, and stick with that same approach every day. Your doctor will start you at a low dose and gradually increase it every 1–2 days based on how your symptoms respond.

  • Do not take a dose close to bedtime — the 3-hour gap before sleep is important for safety
  • If you miss a dose, take your next scheduled dose at the usual time; do not take extra to make up for the missed one

Dosing details from the FDA-approved label

From the Droxidopa prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Dosing information (starting dose and titration; the label names no specific indication or patient group)
    • Starting dose is 100 mg, taken orally three times daily: upon arising in the morning, at midday, and in the late afternoon at least 3 hours prior to bedtime
    • Titrate to symptomatic response, in increments of 100 mg three times daily every 24 to 48 hours
    • Maximum: 600 mg three times daily (i.e., a maximum total daily dose of 1,800 mg)
    • Take consistently with or without food; take capsule whole; elevate the head of the bed to reduce potential for supine hypertension; monitor supine blood pressure prior to initiating and after increasing the dose; if a dose is missed, take the next scheduled dose
Read the label’s full dosing text

2 DOSAGE AND ADMINISTRATION Starting dose is 100 mg three times during the day ( 2.1 ) Titrate by 100 mg three times daily, up to a maximum dose of 600 mg three times daily ( 2.1 ) Take consistently with or without food ( 2.1 ) To reduce the potential for supine hypertension, elevate the head of the bed and give the last dose at least 3 hours prior to bedtime ( 2.1 ) Take Droxidopa capsule whole ( 2.1 ) 2.1 Dosing Information The recommended starting dose of Droxidopa capsule is 100 mg, taken orally three times daily: upon arising in the morning, at midday, and in the late afternoon at least 3 hours prior to bedtime (to reduce the potential for supine hypertension during sleep). Administer Droxidopa capsule consistently, either with food or without food. Take Droxidopa capsule whole. Titrate to symptomatic response, in increments of 100 mg three times daily every 24 to 48 hours up to a maximum dose of 600 mg three times daily (i.e., a maximum total daily dose of 1,800 mg). Monitor supine blood pressure prior to initiating Droxidopa and after increasing the dose. Patients who miss a dose of Droxidopa should take their next scheduled dose.

2.1 Dosing Information The recommended starting dose of Droxidopa capsule is 100 mg, taken orally three times daily: upon arising in the morning, at midday, and in the late afternoon at least 3 hours prior to bedtime (to reduce the potential for supine hypertension during sleep). Administer Droxidopa capsule consistently, either with food or without food. Take Droxidopa capsule whole. Titrate to symptomatic response, in increments of 100 mg three times daily every 24 to 48 hours up to a maximum dose of 600 mg three times daily (i.e., a maximum total daily dose of 1,800 mg). Monitor supine blood pressure prior to initiating Droxidopa and after increasing the dose. Patients who miss a dose of Droxidopa should take their next scheduled dose.

Read the full Dosage and Administration section on DailyMed →

Droxidopa side effects

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The most common side effects reported in clinical trials include:

Common side effects

  • Headache
  • Dizziness
  • Nausea
  • High blood pressure (hypertension)
  • Falls
  • Urinary tract infections
  • Fainting (syncope)
  • Fatigue

When to get medical help

  • Call your doctor right away if you have a severe or pounding headache, especially when lying flat — this could be a sign of dangerously high blood pressure (supine hypertension)
  • Seek emergency help immediately for signs of stroke: sudden face drooping, arm weakness, or speech trouble
  • Get medical help urgently for high fever, severe muscle stiffness, confusion, or unusual movements — these could signal a rare but life-threatening reaction called neuroleptic malignant syndrome (NMS)
  • Tell your doctor if you develop chest pain or notice worsening heart symptoms
  • Seek emergency care for signs of a serious allergic reaction: throat swelling, severe rash, trouble breathing (anaphylaxis or angioedema)
  • Report any new or worsening confusion, hallucinations, or psychosis to your doctor promptly

High blood pressure and nausea were the most common reasons people stopped taking the medication in trials. More rarely, reports after the drug was on the market have included chest pain, blurred vision, vomiting, diarrhea, pancreatitis, and psychiatric symptoms like hallucinations or confusion — contact your doctor right away if any of these occur.

Droxidopa warnings and precautions

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  • Supine hypertension (high blood pressure while lying flat): This is the most critical risk. If not controlled, it can increase the chance of stroke. Always elevate the head of your bed, take your last dose at least 3 hours before sleep, and have your blood pressure monitored regularly — especially when doses are being adjusted.
  • Neuroleptic malignant syndrome (NMS): A rare but life-threatening reaction involving high fever, severe muscle stiffness, confusion, and abnormal movements. Risk is highest when your droxidopa dose changes or if levodopa is suddenly stopped, especially alongside antipsychotic drugs. Seek emergency care immediately.
  • Heart conditions: Droxidopa may worsen existing ischemic heart disease (reduced blood flow to the heart), irregular heartbeat (arrhythmia), or congestive heart failure. Your doctor should weigh this carefully before starting treatment.
  • Allergic reactions: Serious reactions including anaphylaxis (a severe whole-body allergic response), swelling of the face or throat (angioedema), and rash have been reported. Some formulations contain a dye (tartrazine) that can trigger reactions in people sensitive to aspirin. Stop the medication and get emergency help if this happens.

Droxidopa interactions

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Droxidopa can interact with several types of medications, mainly by pushing blood pressure too high or by affecting how droxidopa is processed in the body:

  • Blood pressure-raising drugs (norepinephrine, ephedrine, midodrine, triptans) — combining these with droxidopa significantly increases the risk of dangerously high blood pressure
  • Non-selective MAO inhibitors and linezolid — should be avoided; they can cause a sharp, unsafe spike in blood pressure when taken with droxidopa
  • Levodopa/carbidopa and other dopa-decarboxylase inhibitors — carbidopa can block the conversion of droxidopa to norepinephrine outside the brain, and can also increase overall droxidopa exposure in the body; dose adjustments may be needed
  • Selective MAO-B inhibitors (rasagiline, selegiline) — used alongside droxidopa in clinical trials without requiring dose changes, but always tell your doctor about all your medications

Interactions listed in the FDA-approved label

From the Droxidopa prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Drugs that increase blood pressure (e.g., norepinephrine, ephedrine, midodrine, and triptans): Administering Droxidopa in combination with other agents that increase blood pressure would be expected to increase the risk for supine hypertension.
  • Parkinson's medications (dopa-decarboxylase inhibitors): Dopa-decarboxylase inhibitors may require dose adjustments for Droxidopa. Dose adjustments of Droxidopa may be required.
  • Non-selective MAO inhibitors and linezolid: Based on mechanism of action, there is a potential for increased blood pressure when taken with Droxidopa. Should be avoided.
  • Selective MAO-B inhibitors (rasagiline, selegiline): Concomitant use was permitted in the Droxidopa clinical trials.
Read the label’s full interactions text

7 DRUG INTERACTIONS Use of DOPA decarboxylase inhibitors may require dose adjustments for Droxidopa capsule ( 7.2 ) 7.1 Drugs that Increase Blood Pressure Administering Droxidopa capsule in combination with other agents that increase blood pressure (e.g., norepinephrine, ephedrine, midodrine, and triptans) would be expected to increase the risk for supine hypertension. 7.2 Parkinson's Medications Dopa-decarboxylase inhibitors may require dose adjustments for Droxidopa capsule. 7.3 Non-selective MAO inhibitors The concomitant use of selective MAO-B inhibitors, such as rasagiline or selegiline, was permitted in the Droxidopa capsule clinical trials. However, based on mechanism of action, the use of non-selective MAO inhibitors and linezolid should be avoided as there is a potential for increased blood pressure when taken with Droxidopa capsule.

7.1 Drugs that Increase Blood Pressure Administering Droxidopa capsule in combination with other agents that increase blood pressure (e.g., norepinephrine, ephedrine, midodrine, and triptans) would be expected to increase the risk for supine hypertension.

7.2 Parkinson's Medications Dopa-decarboxylase inhibitors may require dose adjustments for Droxidopa capsule.

7.3 Non-selective MAO inhibitors The concomitant use of selective MAO-B inhibitors, such as rasagiline or selegiline, was permitted in the Droxidopa capsule clinical trials. However, based on mechanism of action, the use of non-selective MAO inhibitors and linezolid should be avoided as there is a potential for increased blood pressure when taken with Droxidopa capsule.

Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿17 supplements and herbs with documented Droxidopa interactions, ranked by severity Check Droxidopa against a supplement or herb →

Before taking Droxidopa

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  • Do not take droxidopa if you have ever had a serious allergic reaction to it or any of its ingredients
  • Tell your doctor if you have heart disease, irregular heart rhythm (arrhythmia), or congestive heart failure — droxidopa may make these conditions worse
  • If you are pregnant or trying to become pregnant, talk to your doctor; animal studies showed potential harm to offspring across generations
  • Do not breastfeed while taking droxidopa — it passes into animal milk and may harm nursing infants; the risk to human infants is unknown but considered serious enough to recommend against it
  • Droxidopa has not been studied in children; safety and effectiveness in pediatric patients are not established
  • Older adults (75+) were included in clinical trials with no major differences found, but individual sensitivity may vary
  • If you have severe kidney disease (GFR below 30 mL/min), clear dosing guidance does not exist — discuss this with your doctor before starting
  • If you are sensitive to aspirin or have asthma, some droxidopa formulations contain FD&C Yellow No. 5 (tartrazine), which can trigger allergic reactions

Droxidopa overdose

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Taking too much droxidopa can cause a dangerous spike in blood pressure. Reported overdose cases involved a hypertensive crisis (extremely high blood pressure) and, in one case, bleeding in the brain (intracranial hemorrhage). There is no antidote. If an overdose is suspected, call emergency services; in the meantime, staying upright — standing or seated — may help bring blood pressure down while waiting for medical help.

What Droxidopa does in the body

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Droxidopa raises both systolic and diastolic blood pressure (the top and bottom numbers), with the effect peaking around the same time as peak drug levels in the blood. It does not meaningfully change heart rate whether you are standing or lying down. Studies at high single doses showed no effect on the heart's electrical rhythm (no QTc prolongation), which is reassuring for heart safety.

How your body processes Droxidopa

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After swallowing a droxidopa capsule, peak blood levels are typically reached within 1 to 4 hours (on average about 2 hours). Eating a high-fat meal around the same time can reduce and delay absorption somewhat, which is why consistent timing with or without food matters. The body breaks droxidopa down mainly through the catecholamine pathway — not through the liver's cytochrome P450 system, which is relevant because many drug interactions happen through that system. The drug and its breakdown products are cleared primarily by the kidneys, with a half-life of roughly 2.5 hours — meaning it leaves the body relatively quickly.

How to store Droxidopa

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stored at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) . Dispense in a tight, light-resistant container with a child resistant closure

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

17

Supplements & herbs that interact with Droxidopa

17 supplements and herbal products have documented interactions with Droxidopa in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 1
  • Moderate · 7
  • Minor · 9
ACTIVATED CHARCOAL Major COFFEE CHARCOAL Moderate EUROPEAN MANDRAKE Moderate GLUCOMANNAN Moderate GUAR GUM Moderate GUM ARABIC Moderate SLIPPERY ELM Moderate TRAGACANTH Moderate +9 more
Every supplement checked against Droxidopa — ranked by severity The full interaction hub: 1 major · 7 moderate · 9 minor · every one linked to its full report. Check Droxidopa against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

Droxidopa: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Droxidopa — the kind of thing our pharmacy team would talk through with you at the counter.

What exactly is droxidopa supposed to do for me?

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It's designed to reduce the dizziness, lightheadedness, and near-blackouts you get when you stand up — a problem called neurogenic orthostatic hypotension, or nOH. Your nervous system isn't sending the right signals to keep your blood pressure steady when you change positions, and droxidopa helps fill that gap by converting into a chemical (norepinephrine) that tightens your blood vessels and supports your blood pressure when you rise.

When during the day should I take my doses, and does food matter?

▾
You take it three times a day — morning, midday, and in the late afternoon. The critical rule is that your last dose has to be at least 3 hours before you go to bed, because it can raise your blood pressure too much while you're lying flat overnight. As for food, it doesn't matter much whether you take it with a meal or not — but you should pick one approach and stick with it every day. Switching back and forth can affect how much gets absorbed.

Is it okay that my blood pressure goes up — I thought that was bad?

▾
For you, the goal is specifically to raise your blood pressure when you stand up, because right now it's dropping too low and making you feel faint. The tricky part is making sure it doesn't go too high when you're lying down (called supine hypertension). That's why you're asked to sleep with the head of your bed raised, and why your doctor will monitor your blood pressure regularly. If your lying-down pressure gets too high and can't be managed, the dose may need to be adjusted.

What side effects are most likely, and which ones mean I should call someone right away?

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The most common ones are headache, dizziness, nausea, and high blood pressure — most people who had to stop the medication in studies did so because of blood pressure or nausea. Call your doctor promptly if you get a throbbing headache when lying down, since that can signal blood pressure that's too high. Get emergency help immediately if you develop a sudden high fever with severe muscle stiffness and confusion, any signs of stroke (face drooping, arm weakness, slurred speech), or a severe allergic reaction like throat swelling or difficulty breathing.

I take levodopa/carbidopa for Parkinson's — is that okay to combine with droxidopa?

▾
Many people in the clinical trials took both, so your doctor is likely already aware of this combination. One thing worth knowing: carbidopa can block droxidopa from being fully converted to the active chemical outside the brain, and it can also raise the overall amount of droxidopa in your system. In practice, this didn't require a different dose for most people in studies, but your doctor may want to monitor you more closely. Never stop levodopa suddenly while on droxidopa, as that can trigger a rare but serious reaction.

Can I take droxidopa if I'm pregnant or breastfeeding?

▾
There is no human data on droxidopa in pregnancy, and animal studies did show some concerns for developing offspring across generations. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor before starting — or as soon as possible if you're already taking it. Breastfeeding is not recommended while on droxidopa because of the potential for serious effects on a nursing infant.

Is Droxidopa available over the counter?

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No. Droxidopa is a prescription medicine: every Droxidopa product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Droxidopa first available?

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The earliest FDA record we hold for Droxidopa is from 2014: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Droxidopa was first used.

Who makes Droxidopa?

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15 companies currently list Droxidopa products in the FDA's NDC Directory, including Ascend Laboratories, LLC, Aurobindo Pharma Limited, Bionpharma Inc.. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Droxidopa on HelloPharmacist

📊Droxidopa supplement interactions17 checked — ranked by severity 🌿Drug & Supplement CheckerDroxidopa vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Droxidopa NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Droxidopa Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Droxidopa forms and strengths (how it comes)

Droxidopa is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Capsule

By mouth
Brands Northera
How this form is used
What it may be used for
  • Northera is used to treat orthostatic dizziness, lightheadedness, and near-fainting in adults with neurogenic orthostatic hypotension (nOH) caused by Parkinson's disease, multiple system atrophy, pure autonomic failure, dopamine beta-hydroxylase deficiency, or non-diabetic autonomic neuropathy
  • Droxidopa capsules are used for the same indication: treating dizziness, lightheadedness, and near-fainting due to neurogenic orthostatic hypotension in adults with the same underlying conditions
Important instructions
  • Northera: swallow the capsule whole — do not crush or open it
  • Droxidopa capsule: swallow whole; take three times daily (morning, midday, and at least 3 hours before bedtime)
  • Both Northera and Droxidopa capsule should be taken consistently either always with food or always without food — do not switch back and forth
  • If you miss a dose of Northera or Droxidopa capsule, skip it and take your next dose at the scheduled time
Available strengths 6 strengths
100 mcg 200 mcg 300 mcg 100 mg 200 mg 300 mg
72 FDA-listed product records ⓘ

Droxidopa on the U.S. market: products, makers and brands

How Droxidopa appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

15 companies list 45 Droxidopa product records with the FDA, mostly as capsule; the earliest marketing or approval year on record is 2014. Brand names on the directory include Northera; the rest are generics.

1
Dose forms ⓘ
15
Labelers (makers, repackagers, distributors)
2
Brand names
45
FDA-listed product records ⓘ
2014
Earliest FDA record ⓘ

Also listed with the FDA, not a patient dose form: Powder (7) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Ascend Laboratories, LLC7%
Aurobindo Pharma Limited7%
Bionpharma Inc.7%
Camber Pharmaceuticals, Inc.7%
CivicaScript LLC7%
Golden State Medical Supply, Inc.7%
Other makers60%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Droxidopa is used (Medicaid data)

A general measure of how commonly Droxidopa is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Droxidopa is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

1,239
Medicaid prescriptions filled (Q1–Q4 2025)
$231,202 gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Droxidopa prescribed? Of the 1,601 medications we measure, Droxidopa ranks #1,259 by Medicaid prescriptions — more than 21% of them.

Where Droxidopa ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #1,259 of 1,601
#1,254 Asparaginase Erwinia C... 1,281 Rx #1,255 Phenelzine 1,254 Rx #1,256 Perindopril 1,251 Rx #1,257 Daratumumab Injection 1,247 Rx #1,258 Triamterene 1,245 Rx #1,259 Droxidopa 1,239 Rx #1,260 Diethylpropion 1,227 Rx #1,261 Amiloride and Hydrochl... 1,216 Rx #1,262 Lurbinectedin Injectio... 1,194 Rx #1,263 Donepezil / Memantine 1,194 Rx #1,264 Tasimelteon 1,179 Rx

Utilization by Droxidopa product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 100 mg oral capsule is the most-dispensed Droxidopa product — about 74% of these Medicaid prescriptions.

droxidopa 100 MG Oral Capsule Most dispensed

913 Medicaid prescriptions (Q1–Q4 2025) 74% of Droxidopa prescriptions shown $104,666 gross reimbursement (before rebates) ≈ $115 per prescription (gross)

Summed across the 4 of 27 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1490026

droxidopa 200 MG Oral Capsule

175 Medicaid prescriptions (Q1–Q4 2025) 14% of Droxidopa prescriptions shown $27,763 gross reimbursement (before rebates) ≈ $159 per prescription (gross)

Summed across the 2 of 27 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1490034

droxidopa 300 MG Oral Capsule

151 Medicaid prescriptions (Q1–Q4 2025) 12% of Droxidopa prescriptions shown $98,773 gross reimbursement (before rebates) ≈ $654 per prescription (gross)

Summed across the 2 of 27 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1490038

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Droxidopa, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 8 of 81 listed Droxidopa NDCs with Medicaid activity.

Compare Droxidopa products

A representative set of FDA-listed product records for Droxidopa — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 45 of 45 products — FDA National Drug Code Directory. See every product, package size and price: browse all 45 Droxidopa NDCs →

Droxidopa recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list no Droxidopa recalls since July 2021.

✅No Droxidopa recalls on record since July 2021

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Droxidopa RxCUI 1489913 1 dose form · 3 strengths
  1. Dose form (SCDF) Oral Capsule RxCUI 1490025 In current FDA listings
    Clinical drug / strength (SCD) 100 MG RxCUI 1490026 200 MG RxCUI 1490034 300 MG RxCUI 1490038

Look up RxCUI 1489913 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

💵 What Droxidopa costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Capsule · Oral 100 mg $0.472 per capsule NDC details & price history
Capsule · Oral 200 mg $0.901 per capsule NDC details & price history
Capsule · Oral 300 mg $1.84 per capsule NDC details & price history
Capsule · Oral 100 mcg $0.674 per capsule NDC details & price history
Capsule · Oral 200 mcg $1.67 per capsule NDC details & price history
Capsule · Oral 300 mcg $2.60 per capsule NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Droxidopa brand names

Droxidopa is sold under one brand name in the FDA directory — Northera. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Northera

Who makes Droxidopa: manufacturers and labelers

15 companies list Droxidopa products with the FDA. By number of product records, the largest are Ascend Laboratories, LLC, Aurobindo Pharma Limited, Bionpharma Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Ascend Laboratories, LLC 3 Aurobindo Pharma Limited 3 Bionpharma Inc. 3 Camber Pharmaceuticals, Inc. 3 CivicaScript LLC 3 Golden State Medical Supply, Inc. 3 Lundbeck Pharmaceuticals LLC 3 Lupin Pharmaceuticals, Inc. 3 Major Pharmaceuticals 3 Novadoz Pharmaceuticals LLC 3 ScieGen Pharmaceuticals Inc 3 Slate Run Pharmaceuticals, LLC 3 Sun Pharmaceutical Industries, Inc. 3 Zydus Lifesciences Limited 3 Zydus Pharmaceuticals USA Inc. 3

Droxidopa drug class (RxNorm)

Droxidopa belongs to the Adrenergic and dopaminergic agents class.

Drug family (ATC) Adrenergic and dopaminergic agents

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Droxidopa page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

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FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Jul 1, 2019
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Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Droxidopa.
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Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
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Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Droxidopa after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
16
Finished products in the current FDA directory
45
Companies listing them (makers, repackagers, distributors)
15
FDA labeler codes behind them ⓘ
15
Linked representative label ⓘ
Lundbeck Pharmaceuticals LLC
Linked label effective
Jul 1, 2019
Composite sections available
23
Linked SPL Set ID
2179f02c-48d7-48eb-8007-5ae43d8d16bc
Linked SPL Document ID
5e69b39c-3254-43bc-ae4d-258222a964d5
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Lundbeck Pharmaceuticals LLC is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →