Cenobamate

Generic name: Pronounced as (sen" oh bam' ate)
Brand names
  • Xcopri®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 04/15/2020

Cenobamate is used alone or with other medications to treat certain types of partial onset seizures (seizures that involve only one part of the brain) in adults. Cenobamate is in a class of medications called anticonvulsants. It works by decreasing abnormal electrical activity in the brain.

Cenobamate comes as a tablet to take by mouth. It is usually taken once daily with or without food. Take cenobamate at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take cenobamate exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole with liquid; do not split, chew, or crush them.

Your doctor will probably start you on a low dose of cenobamate and gradually increase your dose, not more than once every 2 weeks.

Cenobamate may be habit forming. Do not take a larger dose, take it more often, or take it for a longer period of time than prescribed by your doctor.

Cenobamate may help control your condition, but it does not cure it. Do not stop taking cenobamate without talking to your doctor. If you suddenly stop taking cenobamate, your seizures may become worse. Your doctor will probably decrease your dose gradually.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking cenobamate,

  • tell your doctor and pharmacist if you are allergic to cenobamate, any other medications, or any of the ingredients in cenobamate tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: medications for allergies, anxiety, cough and cold, mental illness, and pain; medications for seizures such as carbamazepine (Equetro, Tegretol, Teril), clobazam (Sympazan), lamotrigine (Lamictal), phenobarbital, and phenytoin (Dilantin, Phenytek); sedatives; sleeping pills, and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with cenobamate, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • you should know that cenobamate may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, or implants). Talk to your doctor about methods of birth control that will work for you while taking cenobamate.

  • tell your doctor if you have familial short QT syndrome (an inherited condition that causes irregular heartbeat, dizziness, fainting, or sudden death). Your doctor will probably tell you not to take cenobamate.

  • tell your doctor if you have or have ever had liver or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking cenobamate, call your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking cenobamate.

  • you should know that cenobamate may cause dizziness, drowsiness, and problems with coordination and balance. Do not drive a car, operate machinery, or participate in activities requiring alertness or coordination until you know how this medication affects you.

  • ask your doctor about the safe use of alcoholic beverages while you are taking cenobamate. Alcohol can make the side effects from cenobamate worse.

  • you should know that your mental health may change in unexpected ways and you may become suicidal (thinking about harming or killing yourself or planning or trying to do so) while you are taking cenobamate. A small number of adults and children 5 years of age and older (about 1 in 500 people) who took anticonvulsants like cenobamate to treat various conditions during clinical studies became suicidal during their treatment. Some of these people developed suicidal thoughts and behavior as early as 1 week after they started taking the medication. There is a risk that you may experience changes in your mental health if you take an anticonvulsant medication such as cenobamate, but there may also be a risk that you will experience changes in your mental health if your condition is not treated. You and your doctor will decide whether the risks of taking an anticonvulsant medication are greater than the risks of not taking the medication. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: panic attacks; agitation or restlessness; new or worsening irritability, anxiety, or depression; acting on dangerous impulses; difficulty falling asleep or staying asleep; aggressive, angry, or violent behavior; mania (frenzied, abnormally excited mood); talking or thinking about wanting to hurt yourself or end your life; or any other unusual changes in behavior or mood. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Cenobamate may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • headache

    • tiredness

    • nausea

    • constipation

    • diarrhea

    • vomiting

    • dry mouth

    • heartburn

    • stomach pain

    • loss of appetite

    • weight loss

    • back pain

    • taste changes

    • difficulty readying, writing, or speaking

    • confusion

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the SPECIAL PRECAUTIONS section, call your doctor immediately or get emergency medical treatment:

    • double vision or blurred vision

    • rash; hives; swelling of your face or legs; difficulty swallowing or breathing

    • fever, sore throat, or swollen glands

    • sores in mouth or around eyes

    • unusual bruising or bleeding

    • fatigue or weakness; muscle pain; yellowing of skin or eyes; or dark urine

    • shortness of breath

    • irregular heartbeat or fainting

  • Cenobamate may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor.

Do not let anyone else take your medication. Cenobamate is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The serum concentration of Repaglinide can be decreased when it is combined with Cenobamate.
Montelukast Montelukast The serum concentration of Cenobamate can be decreased when it is combined with Montelukast.
Delavirdine Delavirdine The serum concentration of Cenobamate can be decreased when it is combined with Delavirdine.
Nevirapine Nevirapine The serum concentration of Nevirapine can be decreased when it is combined with Cenobamate.
Atorvastatin Atorvastatin The metabolism of Cenobamate can be decreased when combined with Atorvastatin.
Dolasetron Dolasetron The serum concentration of Dolasetron can be decreased when it is combined with Cenobamate.
Aminophylline Aminophylline The serum concentration of Aminophylline can be decreased when it is combined with Cenobamate.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Cenobamate.
Clopidogrel Clopidogrel The serum concentration of Clopidogrel can be decreased when it is combined with Cenobamate.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The serum concentration of Cenobamate can be decreased when it is combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The serum concentration of Conjugated estrogens can be decreased when it is combined with Cenobamate.
Fenofibrate Fenofibrate The serum concentration of Fenofibrate can be decreased when it is combined with Cenobamate.
Guanfacine Guanfacine The serum concentration of Guanfacine can be decreased when it is combined with Cenobamate.
Methylergonovine Methylergonovine The serum concentration of Methylergometrine can be decreased when it is combined with Cenobamate.
Paregoric Paregoric The serum concentration of Morphine can be decreased when it is combined with Cenobamate.
Pentazocine Pentazocine The therapeutic efficacy of Cenobamate can be decreased when used in combination with Pentazocine.
Prednisone Prednisone The serum concentration of Cenobamate can be decreased when it is combined with Prednisone.
Reserpine Reserpine The metabolism of Cenobamate can be increased when combined with Reserpine.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Cenobamate.
Triamcinolone Triamcinolone The serum concentration of Triamcinolone can be decreased when it is combined with Cenobamate.
Doxycycline Injection Doxycycline Injection The serum concentration of Doxycycline can be decreased when it is combined with Cenobamate.
Fluconazole Injection Fluconazole Injection The metabolism of Cenobamate can be decreased when combined with Fluconazole.
Meperidine Injection Meperidine Injection The serum concentration of Meperidine can be decreased when it is combined with Cenobamate.
Methylprednisolone Injection Methylprednisolone Injection The serum concentration of Methylprednisolone can be decreased when it is combined with Cenobamate.
Metoclopramide Injection Metoclopramide Injection The serum concentration of Metoclopramide can be decreased when it is combined with Cenobamate.
Metronidazole Injection Metronidazole Injection The serum concentration of Metronidazole can be decreased when it is combined with Cenobamate.
Morphine Injection Morphine Injection The serum concentration of Morphine can be decreased when it is combined with Cenobamate.
Zidovudine Injection Zidovudine Injection The serum concentration of Cenobamate can be decreased when it is combined with Zidovudine.
Altretamine Altretamine The therapeutic efficacy of Cenobamate can be decreased when used in combination with Amphetamine.
Cyclosporine Cyclosporine The serum concentration of Cenobamate can be decreased when it is combined with Cyclosporine.
Ondansetron Ondansetron The serum concentration of Ondansetron can be decreased when it is combined with Cenobamate.
Granisetron Granisetron The serum concentration of Granisetron can be decreased when it is combined with Cenobamate.
Torsemide Torsemide The metabolism of Torasemide can be increased when combined with Cenobamate.
Olanzapine Olanzapine The metabolism of Cenobamate can be decreased when combined with Olanzapine.
Alosetron Alosetron The serum concentration of Alosetron can be decreased when it is combined with Cenobamate.
Dofetilide Dofetilide The serum concentration of Dofetilide can be decreased when it is combined with Cenobamate.
Hydroxychloroquine Hydroxychloroquine The therapeutic efficacy of Cenobamate can be decreased when used in combination with Hydroxychloroquine.
Meloxicam Meloxicam The serum concentration of Meloxicam can be decreased when it is combined with Cenobamate.
Orlistat Orlistat Orlistat can cause a decrease in the absorption of Cenobamate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Oxcarbazepine Oxcarbazepine The metabolism of Cenobamate can be increased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole The serum concentration of Cenobamate can be decreased when it is combined with Pantoprazole.
Telmisartan Telmisartan The metabolism of Cenobamate can be decreased when combined with Telmisartan.
Zaleplon Zaleplon The serum concentration of Zaleplon can be decreased when it is combined with Cenobamate.
Anakinra Anakinra The metabolism of Cenobamate can be increased when combined with Anakinra.
Linezolid Linezolid The therapeutic efficacy of Cenobamate can be decreased when used in combination with Linezolid.
Trimipramine Trimipramine The serum concentration of Cenobamate can be decreased when it is combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Cenobamate can be increased when combined with Etanercept.
Modafinil Modafinil The serum concentration of Cenobamate can be decreased when it is combined with Modafinil.
Tenofovir Tenofovir The serum concentration of Tenofovir can be decreased when it is combined with Cenobamate.
Sirolimus Sirolimus The serum concentration of Sirolimus can be decreased when it is combined with Cenobamate.
Dutasteride Dutasteride The serum concentration of Dutasteride can be decreased when it is combined with Cenobamate.
Eplerenone Eplerenone The serum concentration of Eplerenone can be decreased when it is combined with Cenobamate.
Escitalopram Escitalopram The serum concentration of Escitalopram can be decreased when it is combined with Cenobamate.
Zonisamide Zonisamide The serum concentration of Zonisamide can be decreased when it is combined with Cenobamate.
Adalimumab Injection Adalimumab Injection The metabolism of Cenobamate can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The serum concentration of Aripiprazole can be decreased when it is combined with Cenobamate.
Atazanavir Atazanavir The serum concentration of Atazanavir can be decreased when it is combined with Cenobamate.
Almotriptan Almotriptan The serum concentration of Almotriptan can be decreased when it is combined with Cenobamate.
Eletriptan Eletriptan The serum concentration of Eletriptan can be decreased when it is combined with Cenobamate.
Mefloquine Mefloquine The therapeutic efficacy of Cenobamate can be decreased when used in combination with Mefloquine.
Rosuvastatin Rosuvastatin The serum concentration of Rosuvastatin can be decreased when it is combined with Cenobamate.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Cenobamate.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Cenobamate.
Aprepitant Aprepitant The serum concentration of Aprepitant can be decreased when it is combined with Cenobamate.
Memantine Memantine The metabolism of Cenobamate can be decreased when combined with Memantine.
Tegaserod Tegaserod The metabolism of Cenobamate can be decreased when combined with Tegaserod.
Tadalafil Tadalafil The serum concentration of Tadalafil can be decreased when it is combined with Cenobamate.
Fosamprenavir Fosamprenavir The serum concentration of Fosamprenavir can be decreased when it is combined with Cenobamate.
Progesterone Progesterone The serum concentration of Progesterone can be decreased when it is combined with Cenobamate.
Apomorphine Injection Apomorphine Injection The serum concentration of Apomorphine can be decreased when it is combined with Cenobamate.
Infliximab Injection Infliximab Injection The metabolism of Cenobamate can be increased when combined with Infliximab.
Protriptyline Protriptyline The therapeutic efficacy of Cenobamate can be decreased when used in combination with Protriptyline.
Rifaximin Rifaximin The serum concentration of Cenobamate can be decreased when it is combined with Rifaximin.
Duloxetine Duloxetine The serum concentration of Duloxetine can be decreased when it is combined with Cenobamate.
Norethindrone Norethindrone The serum concentration of Norethisterone can be decreased when it is combined with Cenobamate.
Tinidazole Tinidazole The serum concentration of Tinidazole can be decreased when it is combined with Cenobamate.
Bosentan Bosentan The serum concentration of Bosentan can be decreased when it is combined with Cenobamate.
Cinacalcet Cinacalcet The serum concentration of Cinacalcet can be decreased when it is combined with Cenobamate.
Erlotinib Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Cenobamate.
Eszopiclone Eszopiclone The serum concentration of Eszopiclone can be decreased when it is combined with Cenobamate.
Ganciclovir Ganciclovir The therapeutic efficacy of Cenobamate can be decreased when used in combination with Ganciclovir.
Solifenacin Solifenacin The serum concentration of Solifenacin can be decreased when it is combined with Cenobamate.
Valganciclovir Valganciclovir The therapeutic efficacy of Cenobamate can be decreased when used in combination with Valganciclovir.
Voriconazole Voriconazole The serum concentration of Cenobamate can be decreased when it is combined with Voriconazole.
Dextroamphetamine Dextroamphetamine The therapeutic efficacy of Cenobamate can be decreased when used in combination with Amphetamine.
Isocarboxazid Isocarboxazid The therapeutic efficacy of Cenobamate can be decreased when used in combination with Isocarboxazid.
Ramelteon Ramelteon The serum concentration of Ramelteon can be decreased when it is combined with Cenobamate.
Darifenacin Darifenacin The serum concentration of Darifenacin can be decreased when it is combined with Cenobamate.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Cenobamate.
Tipranavir Tipranavir The serum concentration of Tipranavir can be decreased when it is combined with Cenobamate.
Felbamate Felbamate The serum concentration of Cenobamate can be decreased when it is combined with Felbamate.
Ranolazine Ranolazine The metabolism of Ranolazine can be increased when combined with Cenobamate.
Abatacept Injection Abatacept Injection The metabolism of Cenobamate can be increased when combined with Abatacept.
Rasagiline Rasagiline The therapeutic efficacy of Cenobamate can be decreased when used in combination with Rasagiline.
Imatinib Imatinib The serum concentration of Cenobamate can be decreased when it is combined with Imatinib.
Sitagliptin Sitagliptin The serum concentration of Sitagliptin can be decreased when it is combined with Cenobamate.
Gefitinib Gefitinib The serum concentration of Gefitinib can be decreased when it is combined with Cenobamate.
Paliperidone Paliperidone The serum concentration of Paliperidone can be decreased when it is combined with Cenobamate.
Exemestane Exemestane The serum concentration of Exemestane can be decreased when it is combined with Cenobamate.
Bortezomib Bortezomib The serum concentration of Cenobamate can be decreased when it is combined with Bortezomib.
Posaconazole Posaconazole The serum concentration of Posaconazole can be decreased when it is combined with Cenobamate.
Primaquine Primaquine The serum concentration of Primaquine can be decreased when it is combined with Cenobamate.
Aliskiren Aliskiren The serum concentration of Aliskiren can be decreased when it is combined with Cenobamate.
Darunavir Darunavir The serum concentration of Darunavir can be decreased when it is combined with Cenobamate.
Nabilone Nabilone The metabolism of Cenobamate can be decreased when combined with Nabilone.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Cenobamate.
Sorafenib Sorafenib The serum concentration of Sorafenib can be decreased when it is combined with Cenobamate.
Sunitinib Sunitinib The serum concentration of Sunitinib can be decreased when it is combined with Cenobamate.
Dronabinol Dronabinol The serum concentration of Dronabinol can be decreased when it is combined with Cenobamate.
Lapatinib Lapatinib The serum concentration of Lapatinib can be decreased when it is combined with Cenobamate.
Levocetirizine Levocetirizine The serum concentration of Levocetirizine can be decreased when it is combined with Cenobamate.
Dasatinib Dasatinib The serum concentration of Dasatinib can be decreased when it is combined with Cenobamate.
Mexiletine Mexiletine The serum concentration of Cenobamate can be decreased when it is combined with Mexiletine.
Armodafinil Armodafinil The metabolism of Cenobamate can be decreased when combined with Armodafinil.
Ivermectin Ivermectin The serum concentration of Ivermectin can be decreased when it is combined with Cenobamate.
Temsirolimus Temsirolimus The serum concentration of Temsirolimus can be decreased when it is combined with Cenobamate.
Maraviroc Maraviroc The serum concentration of Maraviroc can be decreased when it is combined with Cenobamate.
Nilotinib Nilotinib The serum concentration of Cenobamate can be decreased when it is combined with Nilotinib.
Toremifene Toremifene The serum concentration of Toremifene can be decreased when it is combined with Cenobamate.
Bexarotene Bexarotene The serum concentration of Bexarotene can be decreased when it is combined with Cenobamate.
Budesonide Budesonide The serum concentration of Budesonide can be decreased when it is combined with Cenobamate.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Cenobamate can be decreased when combined with Chloramphenicol.
Etravirine Etravirine The serum concentration of Etravirine can be decreased when it is combined with Cenobamate.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Cenobamate can be increased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The serum concentration of Cenobamate can be decreased when it is combined with Desvenlafaxine.
Cevimeline Cevimeline The serum concentration of Cevimeline can be decreased when it is combined with Cenobamate.
Nebivolol Nebivolol The serum concentration of Nebivolol can be decreased when it is combined with Cenobamate.
Tretinoin Tretinoin The serum concentration of Tretinoin can be decreased when it is combined with Cenobamate.
Pilocarpine Pilocarpine The metabolism of Cenobamate can be decreased when combined with Pilocarpine.
Certolizumab Injection Certolizumab Injection The metabolism of Cenobamate can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The serum concentration of Ixabepilone can be decreased when it is combined with Cenobamate.
Irinotecan Injection Irinotecan Injection The serum concentration of Irinotecan can be decreased when it is combined with Cenobamate.
Estramustine Estramustine The serum concentration of Estramustine can be decreased when it is combined with Cenobamate.
Praziquantel Praziquantel The serum concentration of Praziquantel can be decreased when it is combined with Cenobamate.
Rufinamide Rufinamide The serum concentration of Rufinamide can be decreased when it is combined with Cenobamate.
Silodosin Silodosin The serum concentration of Silodosin can be decreased when it is combined with Cenobamate.
Midazolam Midazolam The serum concentration of Midazolam can be increased when it is combined with Cenobamate.
Eltrombopag Eltrombopag The metabolism of Cenobamate can be decreased when combined with Eltrombopag.
Milnacipran Milnacipran The serum concentration of Milnacipran can be decreased when it is combined with Cenobamate.
Dexlansoprazole Dexlansoprazole The serum concentration of Cenobamate can be decreased when it is combined with Dexlansoprazole.
Sodium Phosphate Sodium Phosphate The therapeutic efficacy of Cenobamate can be decreased when used in combination with Sodium phosphate, monobasic.
Fesoterodine Fesoterodine The serum concentration of Fesoterodine can be decreased when it is combined with Cenobamate.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Cenobamate.
Prasugrel Prasugrel The serum concentration of Prasugrel can be decreased when it is combined with Cenobamate.
Lacosamide Lacosamide The serum concentration of Lacosamide can be decreased when it is combined with Cenobamate.
Everolimus Everolimus The serum concentration of Everolimus can be decreased when it is combined with Cenobamate.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be decreased when it is combined with Cenobamate.
Dronedarone Dronedarone The serum concentration of Dronedarone can be decreased when it is combined with Cenobamate.
Palonosetron Injection Palonosetron Injection The serum concentration of Palonosetron can be decreased when it is combined with Cenobamate.
Saxagliptin Saxagliptin The serum concentration of Saxagliptin can be decreased when it is combined with Cenobamate.
Romidepsin Injection Romidepsin Injection The serum concentration of Romidepsin can be decreased when it is combined with Cenobamate.
Topotecan Topotecan Cenobamate may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Golimumab Injection Golimumab Injection The metabolism of Cenobamate can be increased when combined with Golimumab.
Pazopanib Pazopanib The serum concentration of Pazopanib can be decreased when it is combined with Cenobamate.
Asenapine Asenapine The serum concentration of Asenapine can be decreased when it is combined with Cenobamate.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be increased when combined with Cenobamate.
Albendazole Albendazole The serum concentration of Albendazole can be decreased when it is combined with Cenobamate.
Ulipristal Ulipristal The serum concentration of Ulipristal can be decreased when it is combined with Cenobamate.
Levonorgestrel Levonorgestrel The serum concentration of Levonorgestrel can be decreased when it is combined with Cenobamate.
Oxymorphone Oxymorphone The serum concentration of Oxymorphone can be decreased when it is combined with Cenobamate.
Tocilizumab Injection Tocilizumab Injection The metabolism of Cenobamate can be increased when combined with Tocilizumab.
Fingolimod Fingolimod The metabolism of Fingolimod can be decreased when combined with Cenobamate.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Cabazitaxel can be decreased when it is combined with Cenobamate.
Lurasidone Lurasidone The serum concentration of Lurasidone can be decreased when it is combined with Cenobamate.
Acetaminophen Injection Acetaminophen Injection The serum concentration of Cenobamate can be decreased when it is combined with Acetaminophen.
Vilazodone Vilazodone The serum concentration of Vilazodone can be decreased when it is combined with Cenobamate.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Cenobamate can be decreased when combined with Aldesleukin.
Busulfan Injection Busulfan Injection The serum concentration of Busulfan can be decreased when it is combined with Cenobamate.
Roflumilast Roflumilast The serum concentration of Roflumilast can be decreased when it is combined with Cenobamate.
Linagliptin Linagliptin The serum concentration of Linagliptin can be decreased when it is combined with Cenobamate.
Rilpivirine Rilpivirine The serum concentration of Rilpivirine can be decreased when it is combined with Cenobamate.
Cyclophosphamide Injection Cyclophosphamide Injection The serum concentration of Cyclophosphamide can be decreased when it is combined with Cenobamate.
Abiraterone Abiraterone The serum concentration of Cenobamate can be decreased when it is combined with Abiraterone.
Rivaroxaban Rivaroxaban The serum concentration of Rivaroxaban can be decreased when it is combined with Cenobamate.
Ticagrelor Ticagrelor The serum concentration of Ticagrelor can be decreased when it is combined with Cenobamate.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be decreased when it is combined with Cenobamate.
Ruxolitinib Ruxolitinib The serum concentration of Ruxolitinib can be decreased when it is combined with Cenobamate.
Vandetanib Vandetanib The serum concentration of Vandetanib can be decreased when it is combined with Cenobamate.
Clobazam Clobazam The serum concentration of Clobazam can be increased when it is combined with Cenobamate.
Vemurafenib Vemurafenib The serum concentration of Cenobamate can be decreased when it is combined with Vemurafenib.
Vismodegib Vismodegib The serum concentration of Cenobamate can be decreased when it is combined with Vismodegib.
Ivacaftor Ivacaftor The serum concentration of Ivacaftor can be decreased when it is combined with Cenobamate.
Axitinib Axitinib The serum concentration of Axitinib can be decreased when it is combined with Cenobamate.
Crizotinib Crizotinib The serum concentration of Crizotinib can be decreased when it is combined with Cenobamate.
Cabergoline Cabergoline The serum concentration of Cabergoline can be decreased when it is combined with Cenobamate.
Ambrisentan Ambrisentan The serum concentration of Ambrisentan can be decreased when it is combined with Cenobamate.
Ezogabine Ezogabine The serum concentration of Tiagabine can be decreased when it is combined with Cenobamate.
Enzalutamide Enzalutamide The serum concentration of Enzalutamide can be decreased when it is combined with Cenobamate.
Mirabegron Mirabegron The serum concentration of Mirabegron can be decreased when it is combined with Cenobamate.
Regorafenib Regorafenib The serum concentration of Cenobamate can be decreased when it is combined with Regorafenib.
Bosutinib Bosutinib The serum concentration of Bosutinib can be decreased when it is combined with Cenobamate.
Corticotropin, Repository Injection Corticotropin, Repository Injection The serum concentration of Corticotropin can be decreased when it is combined with Cenobamate.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The serum concentration of Cabozantinib can be decreased when it is combined with Cenobamate.
Bedaquiline Bedaquiline The serum concentration of Bedaquiline can be decreased when it is combined with Cenobamate.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Cenobamate.
Alogliptin Alogliptin The serum concentration of Alogliptin can be decreased when it is combined with Cenobamate.
Ponatinib Ponatinib The serum concentration of Ponatinib can be decreased when it is combined with Cenobamate.
Pomalidomide Pomalidomide The serum concentration of Pomalidomide can be decreased when it is combined with Cenobamate.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be decreased when it is combined with Cenobamate.
Apixaban Apixaban The serum concentration of Apixaban can be decreased when it is combined with Cenobamate.
Canagliflozin Canagliflozin The serum concentration of Canagliflozin can be decreased when it is combined with Cenobamate.
Dabrafenib Dabrafenib The serum concentration of Cenobamate can be decreased when it is combined with Dabrafenib.
Ospemifene Ospemifene The serum concentration of Cenobamate can be decreased when it is combined with Ospemifene.
Levomilnacipran Levomilnacipran The serum concentration of Levomilnacipran can be decreased when it is combined with Cenobamate.
Vortioxetine Vortioxetine The serum concentration of Vortioxetine can be decreased when it is combined with Cenobamate.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Cenobamate.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Cenobamate.
Lomitapide Lomitapide The serum concentration of Lomitapide can be decreased when it is combined with Cenobamate.
Avanafil Avanafil The serum concentration of Avanafil can be decreased when it is combined with Cenobamate.
Ketorolac Injection Ketorolac Injection The metabolism of Ketorolac can be increased when combined with Cenobamate.
Simeprevir Simeprevir The serum concentration of Simeprevir can be decreased when it is combined with Cenobamate.
Dapagliflozin Dapagliflozin The serum concentration of Dapagliflozin can be decreased when it is combined with Cenobamate.
Apremilast Apremilast The serum concentration of Cenobamate can be decreased when it is combined with Apremilast.
Ceritinib Ceritinib The serum concentration of Ceritinib can be decreased when it is combined with Cenobamate.
Siltuximab Injection Siltuximab Injection The metabolism of Cenobamate can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Cenobamate can be decreased when combined with Eslicarbazepine.
Idelalisib Idelalisib The serum concentration of Idelalisib can be decreased when it is combined with Cenobamate.
Testosterone Injection Testosterone Injection The serum concentration of Testosterone can be decreased when it is combined with Cenobamate.
Oritavancin Injection Oritavancin Injection The metabolism of Cenobamate can be decreased when combined with Oritavancin.
Vorapaxar Vorapaxar The serum concentration of Vorapaxar can be decreased when it is combined with Cenobamate.
Hydrocodone Hydrocodone The serum concentration of Cenobamate can be decreased when it is combined with Hydrocodone.
Suvorexant Suvorexant The serum concentration of Suvorexant can be decreased when it is combined with Cenobamate.
Olaparib Olaparib The serum concentration of Olaparib can be decreased when it is combined with Cenobamate.
Tasimelteon Tasimelteon The serum concentration of Tasimelteon can be decreased when it is combined with Cenobamate.
Riociguat Riociguat The serum concentration of Riociguat can be decreased when it is combined with Cenobamate.
Nintedanib Nintedanib The serum concentration of Nintedanib can be decreased when it is combined with Cenobamate.
Secukinumab Injection Secukinumab Injection The metabolism of Cenobamate can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The serum concentration of Risperidone can be decreased when it is combined with Cenobamate.
Palbociclib Palbociclib The serum concentration of Palbociclib can be decreased when it is combined with Cenobamate.
Lenvatinib Lenvatinib The serum concentration of Cenobamate can be decreased when it is combined with Lenvatinib.
Naloxegol Naloxegol The serum concentration of Naloxegol can be decreased when it is combined with Cenobamate.
Panobinostat Panobinostat The serum concentration of Panobinostat can be decreased when it is combined with Cenobamate.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be decreased when it is combined with Cenobamate.
Ivabradine Ivabradine The serum concentration of Ivabradine can be decreased when it is combined with Cenobamate.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Isavuconazonium can be decreased when it is combined with Cenobamate.
Macitentan Macitentan The serum concentration of Macitentan can be decreased when it is combined with Cenobamate.
Sonidegib Sonidegib The serum concentration of Sonidegib can be decreased when it is combined with Cenobamate.
Flibanserin Flibanserin The serum concentration of Flibanserin can be decreased when it is combined with Cenobamate.
Rolapitant Rolapitant The serum concentration of Rolapitant can be decreased when it is combined with Cenobamate.
Prednisolone Prednisolone The serum concentration of Prednisolone can be decreased when it is combined with Cenobamate.
Daclatasvir Daclatasvir The serum concentration of Daclatasvir can be decreased when it is combined with Cenobamate.
Brexpiprazole Brexpiprazole The serum concentration of Brexpiprazole can be decreased when it is combined with Cenobamate.
Ziprasidone Injection Ziprasidone Injection The serum concentration of Ziprasidone can be decreased when it is combined with Cenobamate.
Cariprazine Cariprazine The serum concentration of Cariprazine can be decreased when it is combined with Cenobamate.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be decreased when it is combined with Cenobamate.
Trabectedin Injection Trabectedin Injection The serum concentration of Trabectedin can be decreased when it is combined with Cenobamate.
Osimertinib Osimertinib The serum concentration of Osimertinib can be decreased when it is combined with Cenobamate.
Alectinib Alectinib The metabolism of Alectinib can be increased when combined with Cenobamate.
Ixazomib Ixazomib The serum concentration of Ixazomib can be decreased when it is combined with Cenobamate.
Rifapentine Rifapentine The serum concentration of Cenobamate can be decreased when it is combined with Rifapentine.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The therapeutic efficacy of Cenobamate can be decreased when used in combination with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The serum concentration of Cenobamate can be decreased when it is combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The serum concentration of Cenobamate can be decreased when it is combined with Brivaracetam.
Venetoclax Venetoclax The serum concentration of Venetoclax can be decreased when it is combined with Cenobamate.
Cobicistat Cobicistat The serum concentration of Cenobamate can be decreased when it is combined with Cobicistat.
Selexipag Selexipag The serum concentration of Selexipag can be decreased when it is combined with Cenobamate.
Rucaparib Rucaparib The serum concentration of Cenobamate can be decreased when it is combined with Rucaparib.
Ribociclib Ribociclib The serum concentration of Ribociclib can be decreased when it is combined with Cenobamate.
Brigatinib Brigatinib The serum concentration of Brigatinib can be decreased when it is combined with Cenobamate.
Doxepin (Insomnia) Doxepin (Insomnia) The serum concentration of Doxepin can be decreased when it is combined with Cenobamate.
Deutetrabenazine Deutetrabenazine The serum concentration of Deutetrabenazine can be decreased when it is combined with Cenobamate.
Valbenazine Valbenazine The serum concentration of Valbenazine can be decreased when it is combined with Cenobamate.
Deflazacort Deflazacort The serum concentration of Cenobamate can be decreased when it is combined with Deflazacort.
Safinamide Safinamide The serum concentration of Cenobamate can be decreased when it is combined with Safinamide.
Midostaurin Midostaurin The serum concentration of Cenobamate can be decreased when it is combined with Midostaurin.
Neratinib Neratinib The serum concentration of Neratinib can be decreased when it is combined with Cenobamate.
Enasidenib Enasidenib The serum concentration of Cenobamate can be decreased when it is combined with Enasidenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The serum concentration of Fosaprepitant can be decreased when it is combined with Cenobamate.
Copanlisib Injection Copanlisib Injection The serum concentration of Copanlisib can be decreased when it is combined with Cenobamate.
Delafloxacin Delafloxacin The metabolism of Cenobamate can be increased when combined with Delafloxacin.
Abemaciclib Abemaciclib The serum concentration of Abemaciclib can be decreased when it is combined with Cenobamate.
Acalabrutinib Acalabrutinib The serum concentration of Cenobamate can be decreased when it is combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Cenobamate can be decreased when combined with Letermovir.
Buprenorphine Injection Buprenorphine Injection The serum concentration of Buprenorphine can be decreased when it is combined with Cenobamate.
Apalutamide Apalutamide The serum concentration of Cenobamate can be increased when it is combined with Apalutamide.
Fostamatinib Fostamatinib The serum concentration of Fostamatinib can be decreased when it is combined with Cenobamate.
Baricitinib Baricitinib The serum concentration of Baricitinib can be decreased when it is combined with Cenobamate.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Cenobamate.
Encorafenib Encorafenib The serum concentration of Encorafenib can be decreased when it is combined with Cenobamate.
Ivosidenib Ivosidenib The serum concentration of Cenobamate can be decreased when it is combined with Ivosidenib.
Elagolix Elagolix The metabolism of Elagolix can be increased when combined with Cenobamate.
Eravacycline Injection Eravacycline Injection The serum concentration of Eravacycline can be decreased when it is combined with Cenobamate.
Doravirine Doravirine The serum concentration of Doravirine can be decreased when it is combined with Cenobamate.
Cannabidiol Cannabidiol The serum concentration of Cannabidiol can be decreased when it is combined with Cenobamate.
Dacomitinib Dacomitinib The serum concentration of Dacomitinib can be decreased when it is combined with Cenobamate.
Duvelisib Duvelisib The serum concentration of Duvelisib can be decreased when it is combined with Cenobamate.
Stiripentol Stiripentol The metabolism of Cenobamate can be decreased when combined with Stiripentol.
Gilteritinib Gilteritinib The serum concentration of Gilteritinib can be decreased when it is combined with Cenobamate.
Glasdegib Glasdegib The serum concentration of Glasdegib can be decreased when it is combined with Cenobamate.
Lorlatinib Lorlatinib The serum concentration of Lorlatinib can be decreased when it is combined with Cenobamate.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be decreased when it is combined with Cenobamate.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The serum concentration of Paclitaxel can be decreased when it is combined with Cenobamate.
Rifamycin Rifamycin The metabolism of Cenobamate can be increased when combined with Rifamycin.
Prucalopride Prucalopride The serum concentration of Prucalopride can be decreased when it is combined with Cenobamate.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Cenobamate can be increased when combined with Emapalumab.
Siponimod Siponimod The serum concentration of Siponimod can be decreased when it is combined with Cenobamate.
Erdafitinib Erdafitinib The serum concentration of Erdafitinib can be decreased when it is combined with Cenobamate.
Esomeprazole Injection Esomeprazole Injection The serum concentration of Cenobamate can be decreased when it is combined with Esomeprazole.
Alpelisib Alpelisib The serum concentration of Alpelisib can be decreased when it is combined with Cenobamate.
Polatuzumab vedotin-piiq Injection Polatuzumab vedotin-piiq Injection The serum concentration of Polatuzumab vedotin can be decreased when it is combined with Cenobamate.
Selinexor Selinexor The serum concentration of Selinexor can be decreased when it is combined with Cenobamate.
Darolutamide Darolutamide The serum concentration of Darolutamide can be decreased when it is combined with Cenobamate.
Triclabendazole Triclabendazole The metabolism of Triclabendazole can be decreased when combined with Cenobamate.
Entrectinib Entrectinib The metabolism of Entrectinib can be increased when combined with Cenobamate.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be increased when combined with Cenobamate.
Upadacitinib Upadacitinib The serum concentration of Upadacitinib can be decreased when it is combined with Cenobamate.
Istradefylline Istradefylline The serum concentration of Istradefylline can be decreased when it is combined with Cenobamate.
Pitolisant Pitolisant The serum concentration of Cenobamate can be decreased when it is combined with Pitolisant.
Pretomanid Pretomanid The serum concentration of Pretomanid can be decreased when it is combined with Cenobamate.
Fedratinib Fedratinib The serum concentration of Fedratinib can be decreased when it is combined with Cenobamate.
Lefamulin Lefamulin The serum concentration of Lefamulin can be decreased when it is combined with Cenobamate.
Phenytoin Injection Phenytoin Injection The serum concentration of Cenobamate can be increased when it is combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The serum concentration of Fosphenytoin can be decreased when it is combined with Cenobamate.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be decreased when it is combined with Cenobamate.
Zanubrutinib Zanubrutinib The serum concentration of Zanubrutinib can be decreased when it is combined with Cenobamate.
Voxelotor Voxelotor The serum concentration of Voxelotor can be decreased when it is combined with Cenobamate.
Avapritinib Avapritinib The serum concentration of Avapritinib can be decreased when it is combined with Cenobamate.
Lumateperone Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Cenobamate.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be decreased when it is combined with Cenobamate.
Tazemetostat Tazemetostat The serum concentration of Tazemetostat can be decreased when it is combined with Cenobamate.
Pemigatinib Pemigatinib The serum concentration of Pemigatinib can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod The metabolism of Ozanimod can be increased when combined with Cenobamate.
Selumetinib Selumetinib The serum concentration of Selumetinib can be decreased when it is combined with Cenobamate.
Rimegepant Rimegepant The serum concentration of Rimegepant can be decreased when it is combined with Cenobamate.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Cenobamate.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be decreased when it is combined with Cenobamate.
Ripretinib Ripretinib The serum concentration of Ripretinib can be decreased when it is combined with Cenobamate.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Cenobamate.
Capmatinib Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Cenobamate.
Lemborexant Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Cenobamate.
Fostemsavir Fostemsavir The serum concentration of Fostemsavir can be decreased when it is combined with Cenobamate.
Lurbinectedin Injection Lurbinectedin Injection The serum concentration of Lurbinectedin can be decreased when it is combined with Cenobamate.
Pralsetinib Pralsetinib The serum concentration of Cenobamate can be decreased when it is combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Cenobamate can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The serum concentration of Drospirenone can be decreased when it is combined with Cenobamate.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The serum concentration of Vitamin E can be decreased when it is combined with Cenobamate.
Theophylline Theophylline The serum concentration of Theophylline can be decreased when it is combined with Cenobamate.
Indomethacin Indomethacin The metabolism of Cenobamate can be decreased when combined with Indomethacin.
Naproxen Naproxen The metabolism of Naproxen can be increased when combined with Cenobamate.
Trazodone Trazodone The serum concentration of Trazodone can be decreased when it is combined with Cenobamate.
Isotretinoin Isotretinoin The serum concentration of Isotretinoin can be decreased when it is combined with Cenobamate.
Phenobarbital Phenobarbital The serum concentration of Cenobamate can be increased when it is combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The serum concentration of Methotrexate can be decreased when it is combined with Cenobamate.
Primidone Primidone The serum concentration of Primidone can be increased when it is combined with Cenobamate.
Methsuximide Methsuximide The serum concentration of Cenobamate can be increased when it is combined with Methsuximide.
Chlorpromazine Chlorpromazine The serum concentration of Chlorpromazine can be decreased when it is combined with Cenobamate.
Diazepam Diazepam The serum concentration of Diazepam can be decreased when it is combined with Cenobamate.
Flurazepam Flurazepam The serum concentration of Cenobamate can be decreased when it is combined with Flurazepam.
Clorazepate Clorazepate The serum concentration of Clorazepic acid can be decreased when it is combined with Cenobamate.
Lorazepam Lorazepam The serum concentration of Lorazepam can be decreased when it is combined with Cenobamate.
Codeine Codeine The serum concentration of Codeine can be decreased when it is combined with Cenobamate.
Bromocriptine Bromocriptine The serum concentration of Bromocriptine can be decreased when it is combined with Cenobamate.
Tranylcypromine Tranylcypromine The metabolism of Cenobamate can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Cenobamate can be decreased when combined with Phenelzine.
Ergoloid Mesylates Ergoloid Mesylates The serum concentration of Ergoloid mesylate can be decreased when it is combined with Cenobamate.
Tetracycline Tetracycline The serum concentration of Tetracycline can be decreased when it is combined with Cenobamate.
Prochlorperazine Prochlorperazine The serum concentration of Prochlorperazine can be decreased when it is combined with Cenobamate.
Thioridazine Thioridazine The serum concentration of Thioridazine can be increased when it is combined with Cenobamate.
Dapsone Dapsone The serum concentration of Dapsone can be decreased when it is combined with Cenobamate.
Sulfadiazine Sulfadiazine The serum concentration of Sulfadiazine can be decreased when it is combined with Cenobamate.
Oxycodone Oxycodone The serum concentration of Oxycodone can be decreased when it is combined with Cenobamate.
Methadone Methadone The serum concentration of Methadone can be decreased when it is combined with Cenobamate.
Oxybutynin Oxybutynin The serum concentration of Oxybutynin can be decreased when it is combined with Cenobamate.
Maprotiline Maprotiline The therapeutic efficacy of Cenobamate can be decreased when used in combination with Maprotiline.
Ibuprofen Ibuprofen The serum concentration of Ibuprofen can be decreased when it is combined with Cenobamate.
Orphenadrine Orphenadrine The serum concentration of Cenobamate can be decreased when it is combined with Orphenadrine.
Fluphenazine Fluphenazine The metabolism of Cenobamate can be decreased when combined with Fluphenazine.
Phentermine Phentermine The serum concentration of Phentermine can be decreased when it is combined with Cenobamate.
Methylphenidate Methylphenidate The therapeutic efficacy of Cenobamate can be decreased when used in combination with Methylphenidate.
Amoxapine Amoxapine The therapeutic efficacy of Cenobamate can be decreased when used in combination with Amoxapine.
Hydrocortisone Hydrocortisone The serum concentration of Hydrocortisone can be decreased when it is combined with Cenobamate.
Doxorubicin Doxorubicin The serum concentration of Cenobamate can be decreased when it is combined with Doxorubicin.
Carbamazepine Carbamazepine The serum concentration of Carbamazepine can be decreased when it is combined with Cenobamate.
Clonidine Clonidine The serum concentration of Clonidine can be decreased when it is combined with Cenobamate.
Cimetidine Cimetidine The metabolism of Cenobamate can be decreased when combined with Cimetidine.
Warfarin Warfarin The serum concentration of Warfarin can be decreased when it is combined with Cenobamate.
Clonazepam Clonazepam The metabolism of Cenobamate can be increased when combined with Clonazepam.
Loperamide Loperamide The serum concentration of Cenobamate can be decreased when it is combined with Loperamide.
Promethazine Promethazine The serum concentration of Cenobamate can be decreased when it is combined with Promethazine.
Daunorubicin Daunorubicin The metabolism of Cenobamate can be increased when combined with Daunorubicin.
Chloroquine Chloroquine The serum concentration of Chloroquine can be decreased when it is combined with Cenobamate.
Quinine Quinine The serum concentration of Quinine can be decreased when it is combined with Cenobamate.
Ethosuximide Ethosuximide The serum concentration of Ethosuximide can be decreased when it is combined with Cenobamate.
Calcitriol Calcitriol The serum concentration of Calcitriol can be decreased when it is combined with Cenobamate.
Sulfinpyrazone Sulfinpyrazone The serum concentration of Cenobamate can be decreased when it is combined with Sulfinpyrazone.
Isosorbide Isosorbide The metabolism of Isosorbide can be increased when combined with Cenobamate.
Clindamycin Injection Clindamycin Injection The serum concentration of Clindamycin can be decreased when it is combined with Cenobamate.
Desipramine Desipramine The serum concentration of Desipramine can be decreased when it is combined with Cenobamate.
Amitriptyline Amitriptyline The serum concentration of Amitriptyline can be decreased when it is combined with Cenobamate.
Imipramine Imipramine The serum concentration of Cenobamate can be decreased when it is combined with Imipramine.
Probenecid Probenecid The metabolism of Cenobamate can be decreased when combined with Probenecid.
Quinidine Quinidine The serum concentration of Quinidine can be decreased when it is combined with Cenobamate.
Isoniazid Isoniazid The metabolism of Cenobamate can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Cenobamate can be increased when combined with Rifampicin.
Disopyramide Disopyramide The serum concentration of Disopyramide can be decreased when it is combined with Cenobamate.
Valproic Acid Valproic Acid The serum concentration of Valproic acid can be decreased when it is combined with Cenobamate.
Tamoxifen Tamoxifen The serum concentration of Tamoxifen can be decreased when it is combined with Cenobamate.
Methimazole Methimazole The metabolism of Cenobamate can be decreased when combined with Methimazole.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be increased when combined with Cenobamate.
Dextromethorphan Dextromethorphan The serum concentration of Dextromethorphan can be decreased when it is combined with Cenobamate.
Cyclobenzaprine Cyclobenzaprine The serum concentration of Cyclobenzaprine can be decreased when it is combined with Cenobamate.
Niacin Niacin The metabolism of Cenobamate can be decreased when combined with Niacin.
Cyproheptadine Cyproheptadine The therapeutic efficacy of Cenobamate can be decreased when used in combination with Cyproheptadine.
Chlorpheniramine Chlorpheniramine The serum concentration of Chlorpheniramine can be decreased when it is combined with Cenobamate.
Brompheniramine Brompheniramine The serum concentration of Cenobamate can be decreased when it is combined with Brompheniramine.
Chlorzoxazone Chlorzoxazone The serum concentration of Cenobamate can be decreased when it is combined with Chlorzoxazone.
Carisoprodol Carisoprodol The serum concentration of Carisoprodol can be increased when it is combined with Cenobamate.
Disulfiram Disulfiram The serum concentration of Disulfiram can be decreased when it is combined with Cenobamate.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The serum concentration of Propranolol can be decreased when it is combined with Cenobamate.
Nortriptyline Nortriptyline The serum concentration of Nortriptyline can be decreased when it is combined with Cenobamate.
Amphotericin B Injection Amphotericin B Injection The therapeutic efficacy of Cenobamate can be decreased when used in combination with Amphotericin B.
Mercaptopurine Mercaptopurine Cenobamate may increase the excretion rate of Mercaptopurine which could result in a lower serum level and potentially a reduction in efficacy.
Fluorouracil Injection Fluorouracil Injection The metabolism of Cenobamate can be increased when combined with Fluorouracil.
Colchicine Colchicine The metabolism of Colchicine can be decreased when combined with Cenobamate.
Cephalexin Cephalexin The serum concentration of Cephalexin can be decreased when it is combined with Cenobamate.
Cefotaxime Injection Cefotaxime Injection The therapeutic efficacy of Cenobamate can be decreased when used in combination with Cefotaxime.
Ketoconazole Ketoconazole The serum concentration of Cenobamate can be decreased when it is combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The serum concentration of Cenobamate can be decreased when it is combined with Thiotepa.
Vincristine Injection Vincristine Injection The serum concentration of Vincristine can be decreased when it is combined with Cenobamate.
Vinblastine Vinblastine The serum concentration of Vinblastine can be decreased when it is combined with Cenobamate.
Metoprolol Metoprolol The serum concentration of Metoprolol can be decreased when it is combined with Cenobamate.
Hydroxyzine Hydroxyzine The serum concentration of Hydroxyzine can be decreased when it is combined with Cenobamate.
Chlorambucil Chlorambucil The therapeutic efficacy of Cenobamate can be decreased when used in combination with Chlorambucil.
Alprazolam Alprazolam The metabolism of Alprazolam can be decreased when combined with Cenobamate.
Triazolam Triazolam The serum concentration of Triazolam can be decreased when it is combined with Cenobamate.
Trimethoprim Trimethoprim The serum concentration of Trimethoprim can be decreased when it is combined with Cenobamate.
Diltiazem Diltiazem The serum concentration of Cenobamate can be decreased when it is combined with Diltiazem.
Nifedipine Nifedipine The serum concentration of Nifedipine can be decreased when it is combined with Cenobamate.
Timolol Timolol The serum concentration of Timolol can be increased when it is combined with Cenobamate.
Verapamil Verapamil The serum concentration of Cenobamate can be decreased when it is combined with Verapamil.
Cisplatin Injection Cisplatin Injection The metabolism of Cenobamate can be decreased when combined with Cisplatin.
Piroxicam Piroxicam The metabolism of Piroxicam can be increased when combined with Cenobamate.
Streptozocin Streptozocin The metabolism of Cenobamate can be increased when combined with Streptozocin.
Etoposide Etoposide The serum concentration of Etoposide can be decreased when it is combined with Cenobamate.
Glyburide Glyburide The serum concentration of Glyburide can be decreased when it is combined with Cenobamate.
Indapamide Indapamide The serum concentration of Indapamide can be decreased when it is combined with Cenobamate.
Pentoxifylline Pentoxifylline Cenobamate may increase the excretion rate of Pentoxifylline which could result in a lower serum level and potentially a reduction in efficacy.
Pentamidine Injection Pentamidine Injection The serum concentration of Pentamidine can be decreased when it is combined with Cenobamate.
Labetalol Labetalol The serum concentration of Labetalol can be increased when it is combined with Cenobamate.
Gemfibrozil Gemfibrozil The serum concentration of Cenobamate can be decreased when it is combined with Gemfibrozil.
Pimozide Pimozide The serum concentration of Pimozide can be decreased when it is combined with Cenobamate.
Amiodarone Amiodarone The serum concentration of Cenobamate can be decreased when it is combined with Amiodarone.
Buspirone Buspirone The serum concentration of Buspirone can be decreased when it is combined with Cenobamate.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Cenobamate.
Ciprofloxacin Ciprofloxacin The metabolism of Cenobamate can be decreased when combined with Ciprofloxacin.
Diclofenac Diclofenac The serum concentration of Cenobamate can be decreased when it is combined with Diclofenac.
Fluoxetine Fluoxetine The serum concentration of Cenobamate can be decreased when it is combined with Fluoxetine.
Nimodipine Nimodipine The serum concentration of Nimodipine can be decreased when it is combined with Cenobamate.
Clozapine Clozapine The serum concentration of Cenobamate can be decreased when it is combined with Clozapine.
Estazolam Estazolam The serum concentration of Estazolam can be decreased when it is combined with Cenobamate.
Clarithromycin Clarithromycin The serum concentration of Cenobamate can be decreased when it is combined with Clarithromycin.
Felodipine Felodipine The serum concentration of Felodipine can be decreased when it is combined with Cenobamate.
Simvastatin Simvastatin The serum concentration of Simvastatin can be decreased when it is combined with Cenobamate.
Amlodipine Amlodipine The metabolism of Amlodipine can be increased when combined with Cenobamate.
Teniposide Injection Teniposide Injection The serum concentration of Teniposide can be decreased when it is combined with Cenobamate.
Itraconazole Itraconazole The serum concentration of Cenobamate can be decreased when it is combined with Itraconazole.
Atovaquone Atovaquone The serum concentration of Atovaquone can be decreased when it is combined with Cenobamate.
Rifabutin Rifabutin The serum concentration of Cenobamate can be decreased when it is combined with Rifabutin.
Bisoprolol Bisoprolol The serum concentration of Bisoprolol can be decreased when it is combined with Cenobamate.
Zolpidem Zolpidem The metabolism of Zolpidem can be increased when combined with Cenobamate.
Doxazosin Doxazosin The serum concentration of Doxazosin can be decreased when it is combined with Cenobamate.
Isradipine Isradipine The serum concentration of Isradipine can be decreased when it is combined with Cenobamate.
Omeprazole Omeprazole The serum concentration of Cenobamate can be decreased when it is combined with Omeprazole.
Cisapride Cisapride The serum concentration of Cisapride can be decreased when it is combined with Cenobamate.
Fluvastatin Fluvastatin The serum concentration of Fluvastatin can be decreased when it is combined with Cenobamate.
Venlafaxine Venlafaxine The serum concentration of Cenobamate can be decreased when it is combined with Venlafaxine.
Famciclovir Famciclovir The serum concentration of Famciclovir can be decreased when it is combined with Cenobamate.
Fluvoxamine Fluvoxamine The serum concentration of Cenobamate can be decreased when it is combined with Fluvoxamine.
Nefazodone Nefazodone The serum concentration of Nefazodone can be decreased when it is combined with Cenobamate.
Lamotrigine Lamotrigine The serum concentration of Lamotrigine can be decreased when it is combined with Cenobamate.
Losartan Losartan The serum concentration of Cenobamate can be decreased when it is combined with Losartan.
Tramadol Tramadol The serum concentration of Cenobamate can be decreased when it is combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The serum concentration of Vinorelbine can be decreased when it is combined with Cenobamate.
Lansoprazole Lansoprazole The serum concentration of Cenobamate can be decreased when it is combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Cenobamate.
Nicardipine Nicardipine The serum concentration of Cenobamate can be decreased when it is combined with Nicardipine.
Bupropion Bupropion The serum concentration of Cenobamate can be decreased when it is combined with Bupropion.
Ticlopidine Ticlopidine The serum concentration of Cenobamate can be decreased when it is combined with Ticlopidine.
Saquinavir Saquinavir The serum concentration of Saquinavir can be decreased when it is combined with Cenobamate.
Nisoldipine Nisoldipine The serum concentration of Nisoldipine can be decreased when it is combined with Cenobamate.
Anastrozole Anastrozole The metabolism of Anastrozole can be increased when combined with Cenobamate.
Indinavir Indinavir The serum concentration of Indinavir can be decreased when it is combined with Cenobamate.
Ritonavir Ritonavir The serum concentration of Cenobamate can be decreased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The serum concentration of Docetaxel can be decreased when it is combined with Cenobamate.
Clomipramine Clomipramine The serum concentration of Cenobamate can be decreased when it is combined with Clomipramine.
Zafirlukast Zafirlukast The serum concentration of Cenobamate can be decreased when it is combined with Zafirlukast.
Mirtazapine Mirtazapine The serum concentration of Mirtazapine can be decreased when it is combined with Cenobamate.
Topiramate Topiramate The metabolism of Cenobamate can be decreased when combined with Topiramate.
Zileuton Zileuton The serum concentration of Zileuton can be decreased when it is combined with Cenobamate.
Donepezil Donepezil The serum concentration of Donepezil can be decreased when it is combined with Cenobamate.
Nelfinavir Nelfinavir The serum concentration of Cenobamate can be decreased when it is combined with Nelfinavir.
Azithromycin Azithromycin The serum concentration of Azithromycin can be decreased when it is combined with Cenobamate.
Loratadine Loratadine The serum concentration of Loratadine can be decreased when it is combined with Cenobamate.
Carvedilol Carvedilol The serum concentration of Carvedilol can be decreased when it is combined with Cenobamate.
Nilutamide Nilutamide The metabolism of Cenobamate can be decreased when combined with Nilutamide.
Flutamide Flutamide The serum concentration of Flutamide can be decreased when it is combined with Cenobamate.
Selegiline Selegiline The serum concentration of Cenobamate can be decreased when it is combined with Selegiline.
Bicalutamide Bicalutamide The serum concentration of Cenobamate can be decreased when it is combined with Bicalutamide.
Sertraline Sertraline The serum concentration of Cenobamate can be decreased when it is combined with Sertraline.
Propafenone Propafenone The serum concentration of Propafenone can be decreased when it is combined with Cenobamate.
Letrozole Letrozole The serum concentration of Cenobamate can be decreased when it is combined with Letrozole.
Raloxifene Raloxifene The metabolism of Cenobamate can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Irbesartan can be increased when combined with Cenobamate.
Tamsulosin Tamsulosin The serum concentration of Tamsulosin can be decreased when it is combined with Cenobamate.
Finasteride Finasteride The serum concentration of Finasteride can be decreased when it is combined with Cenobamate.
Quetiapine Quetiapine The serum concentration of Quetiapine can be decreased when it is combined with Cenobamate.
Paroxetine Paroxetine The serum concentration of Cenobamate can be decreased when it is combined with Paroxetine.
Citalopram Citalopram Citalopram may increase the QTc-prolonging activities of Cenobamate.
Efavirenz Efavirenz The serum concentration of Cenobamate can be decreased when it is combined with Efavirenz.
Sildenafil Sildenafil The serum concentration of Sildenafil can be decreased when it is combined with Cenobamate.
Pioglitazone Pioglitazone The serum concentration of Pioglitazone can be decreased when it is combined with Cenobamate.
Celecoxib Celecoxib The serum concentration of Celecoxib can be decreased when it is combined with Cenobamate.
Rosiglitazone Rosiglitazone The serum concentration of Cenobamate can be decreased when it is combined with Rosiglitazone.
Tolterodine Tolterodine The serum concentration of Tolterodine can be decreased when it is combined with Cenobamate.
Thalidomide Thalidomide The metabolism of Cenobamate can be increased when combined with Thalidomide.
Nateglinide Nateglinide The serum concentration of Nateglinide can be decreased when it is combined with Cenobamate.
Galantamine Galantamine The serum concentration of Galantamine can be decreased when it is combined with Cenobamate.
Rabeprazole Rabeprazole The serum concentration of Cenobamate can be decreased when it is combined with Rabeprazole.
Terbinafine Terbinafine The serum concentration of Terbinafine can be decreased when it is combined with Cenobamate.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists