Lovastatin

Generic name: Pronounced as (loe' va sta tin)
Brand names
  • Altocor®
  • Altoprev®
  • Mevacor®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 02/15/2021

[Posted 07/20/2021]

AUDIENCE: Patient, Health Professional, OBGYN, Cardiology, Endocrinology, Pharmacy

ISSUE: The FDA is requesting revisions to the information about use in pregnancy in the prescribing information of the entire class of statin medicines. These changes include removing the contraindication against using these medicines in all pregnant patients. A contraindication is FDA's strongest warning and is only added when a medicine should not be used because the risk clearly outweighs any possible benefit. Because the benefits of statins may include prevention of serious or potentially fatal events in a small group of very high-risk pregnant patients, contraindicating these drugs in all pregnant women is not appropriate.

FDA expects removing the contraindication will enable health care professionals and patients to make individual decisions about benefit and risk, especially for those at very high risk of heart attack or stroke. This includes patients with homozygous familial hypercholesterolemia and those who have previously had a heart attack or stroke.

BACKGROUND: Statins are a class of prescription medicines that have been used for decades to lower low-density lipoprotein (LDL-C or "bad") cholesterol in the blood. Medicines in the statin class include atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin.

RECOMMENDATIONS:

  • Patients: Patients taking statins should notify their health care professionals if they become pregnant or suspect they are pregnant. Your health care professional will be able to advise whether you should stop taking the medicine during pregnancy and whether you may stop your statin temporarily while breastfeeding. Patients who are at high risk of heart attack or stroke who require statins after giving birth should not breastfeed and should use alternatives such as infant formula.

  • Health Care Professionals: Health care professionals should discontinue statin therapy in most pregnant patients, or they can consider the ongoing therapeutic needs of the individual patient, particularly those at very high risk for cardiovascular events during pregnancy. Because of the chronic nature of cardiovascular disease, treatment of hyperlipidemia is not generally necessary during pregnancy. Discuss with patients whether they may discontinue statins temporarily while breastfeeding. Advise those who require a statin because of their cardiovascular risk that breastfeeding is not recommended because the medicine may pass into breast milk

The FDA hopes the revised language in the prescribing information will help reassure health care professionals that statins are safe to prescribe in patients who can become pregnant, and help them reassure patients with unintended statin exposure in early pregnancy or before pregnancy is recognized that the medicine is unlikely to harm the unborn baby.

For more information visit the FDA website at: http://www.fda.gov/Safety/MedWatch/SafetyInformation and http://www.fda.gov/Drugs/DrugSafety.

Lovastatin is used together with diet, weight-loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. Lovastatin is also used to decrease the amount of cholesterol (a fat-like substance) and other fatty substances in the blood. Lovastatin is in a class of medications called HMG CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. Lowering your blood level of cholesterol and fats with lovastatin may help prevent heart disease, angina (chest pain), strokes, and heart attacks.

Lovastatin comes as a tablet and an extended-release (long-acting) tablet to take by mouth. The regular tablet usually is taken once or twice a day with meals. The extended-release tablet usually is taken once a day at bedtime. Take lovastatin at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lovastatin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the extended-release tablets whole; do not split, chew, or crush them.

Your doctor may start you on a low dose of lovastatin and gradually increase your dose, not more than once every 4 weeks.

Continue to take lovastatin even if you feel well. Do not stop taking lovastatin without talking to your doctor.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking lovastatin,

  • tell your doctor and pharmacist if you are allergic to lovastatin, any other medications, or any of the ingredients in lovastatin tablets or extended-release tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor if you are taking any of the following medications: antifungals such as itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), and voriconazole (Vfend); boceprevir (Victrelis); clarithromycin (Biaxin); cobicistat-containing medications (Stribild); erythromycin (E.E.S.,EryC); nefazodone; certain HIV protease inhibitors including atazanavir (Reyataz), darunavir (Prezista), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), saquinavir (Invirase), and tipranavir (Aptivus); telaprevir (Incivek); and telithromycin (Ketek). Your doctor will probably tell you not to take lovastatin if you are taking one or more of these medications.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Pacerone); anticoagulants ('blood thinners') such as warfarin (Coumadin); cimetidine (Tagamet); colchicine (Colcrys); cyclosporine (Neoral, Sandimmune); danazol (Danocrine); diltiazem (Cardizem, Dilacor, Tiazac); dronedarone (Multaq); other cholesterol-lowering medications such as fenofibrate (Tricor), gemfibrozil (Lopid), and niacin (nicotinic acid, Niacor, Niaspan); spironolactone (Aldactone); ranolazine (Ranexa); and verapamil (Calan, Covera, Isoptin, Verelan) . Many other medications may also interact with lovastatin, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have liver disease. Your doctor will order laboratory tests to see how well your liver is working even if you do not think you have liver disease. Your doctor will probably tell you not to take lovastatin if you have liver disease or if the tests show that you may be developing liver disease.

  • tell your doctor if you drink more than two alcoholic beverages daily, if you are 65 years of age or older, if you have ever had liver disease or if you have or have ever had seizures, muscle aches or weakness, low blood pressure, diabetes, or kidney disease.

  • tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are taking lovastatin. Talk to your doctor about birth control methods that you can use during your treatment. If you become pregnant while taking lovastatin, stop taking lovastatin and call your doctor immediately. Lovastatin may harm the fetus.

  • do not breastfeed while you are taking this medication.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking lovastatin. If you are hospitalized due to serious injury or infection, tell the doctor who treats you that you are taking lovastatin.

  • ask your doctor about the safe use of alcoholic beverages while you are taking lovastatin. Alcohol can increase the risk of serious side effects.

Eat a low-fat, low-cholesterol diet. Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. You can also visit the National Cholesterol Education Program (NCEP) website for additional dietary information at http://www.nhlbi.nih.gov/health/public/heart/chol/chol_tlc.pdf.

Avoid drinking grapefruit juice while taking lovastatin.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Lovastatin may cause side effects. Tell your doctor if these symptoms are severe or do not go away:

    • constipation

    • memory loss or forgetfulness

    • confusion

  • Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately or get emergency medical help:

    • muscle pain, tenderness, or weakness

    • lack of energy

    • weakness

    • fever

    • dark colored urine

    • yellowing of the skin or eyes

    • pain in the upper right part of the stomach

    • extreme tiredness

    • nausea

    • unusual bleeding or bruising

    • loss of appetite

    • flu-like symptoms

    • rash

    • hives

    • itching

    • difficulty breathing or swallowing

    • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

    • hoarseness

  • Lovastatin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor may order laboratory tests during your treatment, especially if you develop symptoms of liver damage.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking lovastatin.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The metabolism of Lovastatin can be decreased when combined with Repaglinide.
Montelukast Montelukast The metabolism of Lovastatin can be decreased when combined with Montelukast.
Leflunomide Leflunomide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Leflunomide.
Delavirdine Delavirdine The serum concentration of Lovastatin can be increased when it is combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Nevirapine can be decreased when combined with Lovastatin.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Lovastatin.
Dolasetron Dolasetron The metabolism of Dolasetron can be decreased when combined with Lovastatin.
Alendronate Alendronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Alendronic acid.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Lovastatin.
Candesartan Candesartan The metabolism of Candesartan can be decreased when combined with Lovastatin.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Lovastatin.
Clopidogrel Clopidogrel The metabolism of Lovastatin can be decreased when combined with Clopidogrel.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The serum concentration of Lovastatin can be increased when it is combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The excretion of Conjugated estrogens can be decreased when combined with Lovastatin.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Lovastatin.
Methylergonovine Methylergonovine The metabolism of Lovastatin can be decreased when combined with Methylergometrine.
Nafarelin Nafarelin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Nafarelin.
Paregoric Paregoric The metabolism of Morphine can be decreased when combined with Lovastatin.
Penbutolol Penbutolol The metabolism of Acebutolol can be decreased when combined with Lovastatin.
Ranitidine Ranitidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Ranitidine.
Reserpine Reserpine Reserpine may decrease the excretion rate of Lovastatin which could result in a higher serum level.
Sumatriptan Sumatriptan The excretion of Sumatriptan can be decreased when combined with Lovastatin.
Tacrolimus Tacrolimus The metabolism of Lovastatin can be decreased when combined with Tacrolimus.
Triamcinolone Triamcinolone The metabolism of Lovastatin can be increased when combined with Triamcinolone.
Fluconazole Injection Fluconazole Injection The metabolism of Lovastatin can be decreased when combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The metabolism of Hydromorphone can be decreased when combined with Lovastatin.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be decreased when combined with Lovastatin.
Metoclopramide Injection Metoclopramide Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Metoclopramide.
Metronidazole Injection Metronidazole Injection The metabolism of Lovastatin can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The metabolism of Morphine can be decreased when combined with Lovastatin.
Pamidronate Injection Pamidronate Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Pamidronic acid.
Zidovudine Injection Zidovudine Injection The metabolism of Lovastatin can be decreased when combined with Zidovudine.
Altretamine Altretamine The metabolism of Amphetamine can be decreased when combined with Lovastatin.
Cyclosporine Cyclosporine The serum concentration of Lovastatin can be increased when it is combined with Cyclosporine.
Ondansetron Ondansetron The metabolism of Lovastatin can be decreased when combined with Ondansetron.
Torsemide Torsemide The metabolism of Torasemide can be decreased when combined with Lovastatin.
Olanzapine Olanzapine The metabolism of Olanzapine can be decreased when combined with Lovastatin.
Alosetron Alosetron The metabolism of Alosetron can be decreased when combined with Lovastatin.
Dofetilide Dofetilide The metabolism of Dofetilide can be decreased when combined with Lovastatin.
Eprosartan Eprosartan The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Eprosartan.
Hydroxychloroquine Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Lovastatin.
Meloxicam Meloxicam The metabolism of Meloxicam can be decreased when combined with Lovastatin.
Oxcarbazepine Oxcarbazepine The metabolism of Lovastatin can be decreased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole The excretion of Lovastatin can be decreased when combined with Pantoprazole.
Risedronate Risedronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Risedronic acid.
Sevelamer Sevelamer Sevelamer can cause a decrease in the absorption of Lovastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Telmisartan Telmisartan Lovastatin may decrease the excretion rate of Telmisartan which could result in a higher serum level.
Zaleplon Zaleplon The metabolism of Zaleplon can be decreased when combined with Lovastatin.
Anakinra Anakinra The metabolism of Lovastatin can be increased when combined with Anakinra.
Trimipramine Trimipramine The metabolism of Trimipramine can be decreased when combined with Lovastatin.
Etanercept Injection Etanercept Injection The metabolism of Lovastatin can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Lovastatin can be increased when combined with Modafinil.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Lovastatin.
Sirolimus Sirolimus The metabolism of Lovastatin can be decreased when combined with Sirolimus.
Dutasteride Dutasteride The metabolism of Dutasteride can be decreased when combined with Lovastatin.
Epinephrine Injection Epinephrine Injection The metabolism of Lovastatin can be decreased when combined with Epinephrine.
Eplerenone Eplerenone The metabolism of Eplerenone can be decreased when combined with Lovastatin.
Escitalopram Escitalopram The metabolism of Escitalopram can be decreased when combined with Lovastatin.
Olmesartan Olmesartan Olmesartan may decrease the excretion rate of Lovastatin which could result in a higher serum level.
Zonisamide Zonisamide The metabolism of Zonisamide can be decreased when combined with Lovastatin.
Adalimumab Injection Adalimumab Injection The metabolism of Lovastatin can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Lovastatin.
Atomoxetine Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Lovastatin.
Ezetimibe Ezetimibe Lovastatin may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Teriparatide Injection Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Lovastatin.
Atazanavir Atazanavir The serum concentration of Lovastatin can be increased when it is combined with Atazanavir.
Almotriptan Almotriptan The metabolism of Almotriptan can be decreased when combined with Lovastatin.
Eletriptan Eletriptan The metabolism of Eletriptan can be decreased when combined with Lovastatin.
Mefloquine Mefloquine The metabolism of Lovastatin can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Lovastatin.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Lovastatin.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Lovastatin.
Aprepitant Aprepitant The metabolism of Lovastatin can be decreased when combined with Aprepitant.
Tegaserod Tegaserod The metabolism of Lovastatin can be decreased when combined with Tegaserod.
Tadalafil Tadalafil The metabolism of Tadalafil can be decreased when combined with Lovastatin.
Progesterone Progesterone The metabolism of Progesterone can be decreased when combined with Lovastatin.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Lovastatin.
Infliximab Injection Infliximab Injection The metabolism of Lovastatin can be increased when combined with Infliximab.
Protriptyline Protriptyline The metabolism of Protriptyline can be decreased when combined with Lovastatin.
Rifaximin Rifaximin The metabolism of Lovastatin can be increased when combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Lovastatin can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Norethisterone can be decreased when combined with Lovastatin.
Tinidazole Tinidazole Lovastatin may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Bosentan Bosentan The serum concentration of Lovastatin can be decreased when it is combined with Bosentan.
Erlotinib Erlotinib The metabolism of Lovastatin can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Lovastatin.
Ganciclovir Ganciclovir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Ganciclovir.
Solifenacin Solifenacin The metabolism of Solifenacin can be decreased when combined with Lovastatin.
Voriconazole Voriconazole The serum concentration of Lovastatin can be increased when it is combined with Voriconazole.
Dextroamphetamine Dextroamphetamine The metabolism of Amphetamine can be decreased when combined with Lovastatin.
Ibandronate Ibandronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Ibandronate.
Ramelteon Ramelteon The metabolism of Ramelteon can be decreased when combined with Lovastatin.
Darifenacin Darifenacin The metabolism of Darifenacin can be decreased when combined with Lovastatin.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Lovastatin.
Deferasirox Deferasirox The metabolism of Lovastatin can be decreased when combined with Deferasirox.
Tipranavir Tipranavir The serum concentration of Lovastatin can be increased when it is combined with Tipranavir.
Ranolazine Ranolazine The risk or severity of myopathy and rhabdomyolysis can be increased when Ranolazine is combined with Lovastatin.
Abatacept Injection Abatacept Injection The metabolism of Lovastatin can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Lovastatin can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The metabolism of Sitagliptin can be decreased when combined with Lovastatin.
Gefitinib Gefitinib The metabolism of Lovastatin can be decreased when combined with Gefitinib.
Paliperidone Paliperidone The metabolism of Paliperidone can be decreased when combined with Lovastatin.
Bortezomib Bortezomib The metabolism of Bortezomib can be decreased when combined with Lovastatin.
Posaconazole Posaconazole The serum concentration of Lovastatin can be increased when it is combined with Posaconazole.
Primaquine Primaquine The metabolism of Lovastatin can be decreased when combined with Primaquine.
Darunavir Darunavir The serum concentration of Lovastatin can be increased when it is combined with Darunavir.
Lisdexamfetamine Lisdexamfetamine The metabolism of Lisdexamfetamine can be decreased when combined with Lovastatin.
Nabilone Nabilone The metabolism of Lovastatin can be decreased when combined with Nabilone.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Lovastatin.
Sorafenib Sorafenib The metabolism of Lovastatin can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Lovastatin can be decreased when combined with Sunitinib.
Dronabinol Dronabinol The metabolism of Dronabinol can be decreased when combined with Lovastatin.
Lapatinib Lapatinib The metabolism of Lovastatin can be decreased when combined with Lapatinib.
Dasatinib Dasatinib The metabolism of Lovastatin can be decreased when combined with Dasatinib.
Mexiletine Mexiletine The metabolism of Mexiletine can be decreased when combined with Lovastatin.
Armodafinil Armodafinil The metabolism of Lovastatin can be increased when combined with Armodafinil.
Ivermectin Ivermectin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Ivermectin is combined with Lovastatin.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Lovastatin.
Nilotinib Nilotinib The serum concentration of Lovastatin can be increased when it is combined with Nilotinib.
Raltegravir Raltegravir The risk or severity of myopathy and rhabdomyolysis can be increased when Raltegravir is combined with Lovastatin.
Bexarotene Bexarotene The metabolism of Bexarotene can be decreased when combined with Lovastatin.
Budesonide Budesonide The metabolism of Lovastatin can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Lovastatin can be decreased when combined with Chloramphenicol.
Etravirine Etravirine The serum concentration of Lovastatin can be decreased when it is combined with Etravirine.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Lovastatin can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The metabolism of Lovastatin can be decreased when combined with Desvenlafaxine.
Cevimeline Cevimeline The metabolism of Cevimeline can be decreased when combined with Lovastatin.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Lovastatin.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Lovastatin.
Pilocarpine Pilocarpine The metabolism of Lovastatin can be decreased when combined with Pilocarpine.
Flecainide Flecainide The metabolism of Flecainide can be decreased when combined with Lovastatin.
Certolizumab Injection Certolizumab Injection The metabolism of Lovastatin can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Lovastatin.
Irinotecan Injection Irinotecan Injection The metabolism of Lovastatin can be decreased when combined with Irinotecan.
Daptomycin Injection Daptomycin Injection The risk or severity of myopathy can be increased when Lovastatin is combined with Daptomycin.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Lovastatin.
Rufinamide Rufinamide The metabolism of Rufinamide can be decreased when combined with Lovastatin.
Midazolam Midazolam The serum concentration of Midazolam can be increased when it is combined with Lovastatin.
Naltrexone Injection Naltrexone Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Naltrexone.
Eltrombopag Eltrombopag The metabolism of Lovastatin can be decreased when combined with Eltrombopag.
Milnacipran Milnacipran The metabolism of Lovastatin can be decreased when combined with Milnacipran.
Fesoterodine Fesoterodine The metabolism of Fesoterodine can be decreased when combined with Lovastatin.
Betaxolol Betaxolol The metabolism of Betaxolol can be decreased when combined with Lovastatin.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Lovastatin.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Lovastatin.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Lovastatin.
Everolimus Everolimus The metabolism of Everolimus can be decreased when combined with Lovastatin.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Tolvaptan can be decreased when combined with Lovastatin.
Dronedarone Dronedarone The risk or severity of myopathy can be increased when Dronedarone is combined with Lovastatin.
Palonosetron Injection Palonosetron Injection The metabolism of Palonosetron can be decreased when combined with Lovastatin.
Saxagliptin Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Lovastatin.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Lovastatin.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Lovastatin.
Topotecan Topotecan The metabolism of Lovastatin can be decreased when combined with Topotecan.
Golimumab Injection Golimumab Injection The metabolism of Lovastatin can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Lovastatin can be decreased when combined with Pazopanib.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Lovastatin.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Lovastatin.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be decreased when combined with Lovastatin.
Oxymorphone Oxymorphone The metabolism of Oxymorphone can be decreased when combined with Lovastatin.
Tocilizumab Injection Tocilizumab Injection The metabolism of Lovastatin can be increased when combined with Tocilizumab.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Lovastatin can be decreased when combined with Cabazitaxel.
Lurasidone Lurasidone The metabolism of Lurasidone can be decreased when combined with Lovastatin.
Acetaminophen Injection Acetaminophen Injection The metabolism of Lovastatin can be decreased when combined with Acetaminophen.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Lovastatin.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Lovastatin can be decreased when combined with Aldesleukin.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be decreased when combined with Lovastatin.
Roflumilast Roflumilast The metabolism of Roflumilast can be decreased when combined with Lovastatin.
Linagliptin Linagliptin The metabolism of Lovastatin can be decreased when combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Lovastatin can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The metabolism of Glecaprevir can be decreased when combined with Lovastatin.
Potassium Iodide Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Lovastatin.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Lovastatin.
Abiraterone Abiraterone The metabolism of Lovastatin can be decreased when combined with Abiraterone.
Rivaroxaban Rivaroxaban The metabolism of Rivaroxaban can be decreased when combined with Lovastatin.
Ticagrelor Ticagrelor The serum concentration of Lovastatin can be increased when it is combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Lovastatin can be decreased when combined with Brentuximab vedotin.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Lovastatin.
Vandetanib Vandetanib The metabolism of Vandetanib can be decreased when combined with Lovastatin.
Vemurafenib Vemurafenib The metabolism of Lovastatin can be decreased when combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Lovastatin can be decreased when combined with Vismodegib.
Ivacaftor Ivacaftor The metabolism of Lovastatin can be decreased when combined with Ivacaftor.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Lovastatin.
Crizotinib Crizotinib The metabolism of Lovastatin can be decreased when combined with Crizotinib.
Cabergoline Cabergoline The metabolism of Lovastatin can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The serum concentration of Lovastatin can be increased when it is combined with Naloxone.
Ambrisentan Ambrisentan The excretion of Ambrisentan can be decreased when combined with Lovastatin.
Iloprost Iloprost The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Iloprost.
Enzalutamide Enzalutamide The metabolism of Enzalutamide can be decreased when combined with Lovastatin.
Mirabegron Mirabegron The metabolism of Mirabegron can be decreased when combined with Lovastatin.
Regorafenib Regorafenib The metabolism of Lovastatin can be decreased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Lovastatin can be decreased when combined with Bosutinib.
Teriflunomide Teriflunomide The metabolism of Lovastatin can be decreased when combined with Teriflunomide.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Lovastatin.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Lovastatin.
Alogliptin Alogliptin The metabolism of Alogliptin can be decreased when combined with Lovastatin.
Ponatinib Ponatinib The metabolism of Lovastatin can be decreased when combined with Ponatinib.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be decreased when combined with Lovastatin.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Lovastatin can be decreased when combined with Trastuzumab emtansine.
Apixaban Apixaban The metabolism of Lovastatin can be decreased when combined with Apixaban.
Dabrafenib Dabrafenib The metabolism of Lovastatin can be decreased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Lovastatin.
Trametinib Trametinib The metabolism of Lovastatin can be decreased when combined with Trametinib.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Lovastatin.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Lovastatin.
Perampanel Perampanel The metabolism of Perampanel can be decreased when combined with Lovastatin.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Lovastatin.
Lomitapide Lomitapide The serum concentration of Lovastatin can be increased when it is combined with Lomitapide.
Avanafil Avanafil The metabolism of Avanafil can be decreased when combined with Lovastatin.
Ketorolac Injection Ketorolac Injection The metabolism of Ketorolac can be decreased when combined with Lovastatin.
Simeprevir Simeprevir The serum concentration of Lovastatin can be increased when it is combined with Simeprevir.
Dapagliflozin Dapagliflozin The metabolism of Lovastatin can be decreased when combined with Dapagliflozin.
Apremilast Apremilast The metabolism of Lovastatin can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Lovastatin can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Lovastatin can be decreased when combined with Siltuximab.
Idelalisib Idelalisib The metabolism of Lovastatin can be decreased when combined with Idelalisib.
Testosterone Injection Testosterone Injection The metabolism of Testosterone can be decreased when combined with Lovastatin.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Lovastatin.
Hydrocodone Hydrocodone The metabolism of Hydrocodone can be decreased when combined with Lovastatin.
Suvorexant Suvorexant The metabolism of Suvorexant can be decreased when combined with Lovastatin.
Olaparib Olaparib The metabolism of Lovastatin can be decreased when combined with Olaparib.
Caspofungin Injection Caspofungin Injection The excretion of Caspofungin can be decreased when combined with Lovastatin.
Methamphetamine Methamphetamine The metabolism of Metamfetamine can be decreased when combined with Lovastatin.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Lovastatin.
Riociguat Riociguat The metabolism of Riociguat can be decreased when combined with Lovastatin.
Lanreotide Injection Lanreotide Injection The metabolism of Lovastatin can be decreased when combined with Lanreotide.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Lovastatin.
Secukinumab Injection Secukinumab Injection The metabolism of Lovastatin can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The metabolism of Risperidone can be decreased when combined with Lovastatin.
Palbociclib Palbociclib The metabolism of Lovastatin can be decreased when combined with Palbociclib.
Lenvatinib Lenvatinib The metabolism of Lovastatin can be decreased when combined with Lenvatinib.
Naloxegol Naloxegol The metabolism of Naloxegol can be decreased when combined with Lovastatin.
Panobinostat Panobinostat The metabolism of Panobinostat can be decreased when combined with Lovastatin.
Haloperidol Injection Haloperidol Injection The metabolism of Lovastatin can be decreased when combined with Haloperidol.
Deoxycholic Acid Injection Deoxycholic Acid Injection Deoxycholic acid may increase the excretion rate of Lovastatin which could result in a lower serum level and potentially a reduction in efficacy.
Ivabradine Ivabradine The metabolism of Lovastatin can be decreased when combined with Ivabradine.
Isavuconazonium Injection Isavuconazonium Injection The metabolism of Lovastatin can be decreased when combined with Isavuconazonium.
Sonidegib Sonidegib The metabolism of Lovastatin can be decreased when combined with Sonidegib.
Flibanserin Flibanserin The metabolism of Lovastatin can be decreased when combined with Flibanserin.
Daclatasvir Daclatasvir The serum concentration of Lovastatin can be increased when it is combined with Daclatasvir.
Brexpiprazole Brexpiprazole The metabolism of Lovastatin can be decreased when combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The metabolism of Lovastatin can be decreased when combined with Ziprasidone.
Cariprazine Cariprazine The metabolism of Cariprazine can be decreased when combined with Lovastatin.
Eluxadoline Eluxadoline The serum concentration of Eluxadoline can be increased when it is combined with Lovastatin.
Cobimetinib Cobimetinib The metabolism of Lovastatin can be decreased when combined with Cobimetinib.
Trabectedin Injection Trabectedin Injection The risk or severity of myopathy and rhabdomyolysis can be increased when Lovastatin is combined with Trabectedin.
Osimertinib Osimertinib The metabolism of Lovastatin can be decreased when combined with Osimertinib.
Alectinib Alectinib The metabolism of Alectinib can be decreased when combined with Lovastatin.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Lovastatin.
Rifapentine Rifapentine The metabolism of Lovastatin can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Lovastatin.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Lovastatin can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Lovastatin can be decreased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Lovastatin.
Venetoclax Venetoclax The metabolism of Lovastatin can be decreased when combined with Venetoclax.
Cobicistat Cobicistat The serum concentration of Lovastatin can be increased when it is combined with Cobicistat.
Selexipag Selexipag The metabolism of Selexipag can be decreased when combined with Lovastatin.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Lovastatin.
Rucaparib Rucaparib The metabolism of Lovastatin can be decreased when combined with Rucaparib.
Ribociclib Ribociclib The serum concentration of Lovastatin can be increased when it is combined with Ribociclib.
Parathyroid Hormone Injection Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Lovastatin.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Lovastatin.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Lovastatin.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Lovastatin.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Lovastatin.
Deflazacort Deflazacort The serum concentration of Lovastatin can be increased when it is combined with Deflazacort.
Safinamide Safinamide The metabolism of Lovastatin can be decreased when combined with Safinamide.
Sarilumab Injection Sarilumab Injection The metabolism of Lovastatin can be decreased when combined with Sarilumab.
Midostaurin Midostaurin The serum concentration of Lovastatin can be increased when it is combined with Midostaurin.
Neratinib Neratinib The metabolism of Neratinib can be decreased when combined with Lovastatin.
Abaloparatide Injection Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Lovastatin.
Enasidenib Enasidenib The metabolism of Lovastatin can be decreased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Lovastatin can be decreased when combined with Fosaprepitant.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Lovastatin.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Lovastatin.
Acalabrutinib Acalabrutinib The metabolism of Lovastatin can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Lovastatin can be decreased when combined with Letermovir.
Tetrabenazine Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Lovastatin.
Ertugliflozin Ertugliflozin The metabolism of Lovastatin can be decreased when combined with Ertugliflozin.
Buprenorphine Injection Buprenorphine Injection The metabolism of Lovastatin can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The metabolism of Apalutamide can be decreased when combined with Lovastatin.
Penicillamine Penicillamine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Penicillamine.
Fostamatinib Fostamatinib The metabolism of Lovastatin can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag The metabolism of Lovastatin can be increased when combined with Avatrombopag.
Baricitinib Baricitinib The metabolism of Baricitinib can be decreased when combined with Lovastatin.
Lofexidine Lofexidine The metabolism of Lofexidine can be decreased when combined with Lovastatin.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Lovastatin.
Encorafenib Encorafenib The metabolism of Encorafenib can be decreased when combined with Lovastatin.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be decreased when combined with Lovastatin.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Lovastatin.
Doravirine Doravirine The metabolism of Doravirine can be decreased when combined with Lovastatin.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Lovastatin.
Cannabidiol Cannabidiol The metabolism of Lovastatin can be decreased when combined with Cannabidiol.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Lovastatin.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Lovastatin.
Stiripentol Stiripentol The serum concentration of Lovastatin can be increased when it is combined with Stiripentol.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Lovastatin.
Glasdegib Glasdegib The metabolism of Glasdegib can be decreased when combined with Lovastatin.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Lovastatin.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Lovastatin.
Rifamycin Rifamycin The metabolism of Lovastatin can be decreased when combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Prucalopride can be decreased when combined with Lovastatin.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Lovastatin can be increased when combined with Emapalumab.
Siponimod Siponimod The risk or severity of adverse effects can be increased when Lovastatin is combined with Siponimod.
Erdafitinib Erdafitinib The metabolism of Lovastatin can be decreased when combined with Erdafitinib.
Alpelisib Alpelisib The metabolism of Lovastatin can be decreased when combined with Alpelisib.
Cladribine Cladribine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Cladribine.
Triclabendazole Triclabendazole The metabolism of Lovastatin can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The metabolism of Entrectinib can be decreased when combined with Lovastatin.
Pexidartinib Pexidartinib The metabolism of Lovastatin can be decreased when combined with Pexidartinib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Lovastatin.
Pitolisant Pitolisant The serum concentration of Lovastatin can be decreased when it is combined with Pitolisant.
Pretomanid Pretomanid The serum concentration of Pretomanid can be increased when it is combined with Lovastatin.
Fedratinib Fedratinib The excretion of Lovastatin can be decreased when combined with Fedratinib.
Lefamulin Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Lovastatin.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Lovastatin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Lovastatin.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Lovastatin.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Lovastatin.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Lovastatin.
Lumateperone Lumateperone The serum concentration of Lumateperone can be increased when it is combined with Lovastatin.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Lovastatin.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Lovastatin.
Bempedoic Acid Bempedoic Acid The excretion of Lovastatin can be decreased when combined with Bempedoic acid.
Cenobamate Cenobamate The metabolism of Lovastatin can be decreased when combined with Cenobamate.
Pemigatinib Pemigatinib The metabolism of Pemigatinib can be decreased when combined with Lovastatin.
Ozanimod Ozanimod The metabolism of Ozanimod can be decreased when combined with Lovastatin.
Selumetinib Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Lovastatin.
Rimegepant Rimegepant The metabolism of Rimegepant can be decreased when combined with Lovastatin.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Lovastatin.
Remdesivir Injection Remdesivir Injection The metabolism of Remdesivir can be decreased when combined with Lovastatin.
Selpercatinib Selpercatinib The serum concentration of Lovastatin can be increased when it is combined with Selpercatinib.
Lemborexant Lemborexant The metabolism of Lemborexant can be decreased when combined with Lovastatin.
Fostemsavir Fostemsavir The serum concentration of Lovastatin can be increased when it is combined with Fostemsavir.
Lurbinectedin Injection Lurbinectedin Injection The serum concentration of Lurbinectedin can be increased when it is combined with Lovastatin.
Octreotide Octreotide The metabolism of Lovastatin can be decreased when combined with Octreotide.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection Lovastatin may decrease the excretion rate of Belantamab mafodotin which could result in a higher serum level.
Pralsetinib Pralsetinib The metabolism of Lovastatin can be decreased when combined with Pralsetinib.
Opicapone Opicapone The metabolism of Lovastatin can be decreased when combined with Opicapone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Lovastatin can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Lovastatin.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Lovastatin.
Indomethacin Indomethacin The metabolism of Lovastatin can be decreased when combined with Indomethacin.
Mefenamic Acid Mefenamic Acid The metabolism of Mefenamic acid can be decreased when combined with Lovastatin.
Naproxen Naproxen The metabolism of Naproxen can be decreased when combined with Lovastatin.
Trazodone Trazodone The metabolism of Trazodone can be decreased when combined with Lovastatin.
Isotretinoin Isotretinoin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Isotretinoin.
Phenobarbital Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Lovastatin.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Lovastatin.
Primidone Primidone The metabolism of Primidone can be decreased when combined with Lovastatin.
Chlorpromazine Chlorpromazine Lovastatin may decrease the excretion rate of Chlorpromazine which could result in a higher serum level.
Diazepam Diazepam The metabolism of Lovastatin can be decreased when combined with Diazepam.
Lorazepam Lorazepam The metabolism of Lorazepam can be decreased when combined with Lovastatin.
Codeine Codeine The metabolism of Codeine can be decreased when combined with Lovastatin.
Bromocriptine Bromocriptine The metabolism of Lovastatin can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Lovastatin can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Lovastatin can be decreased when combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Procarbazine.
Tetracycline Tetracycline The metabolism of Lovastatin can be decreased when combined with Tetracycline.
Minocycline Minocycline The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Minocycline.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be decreased when combined with Lovastatin.
Thioridazine Thioridazine The metabolism of Thioridazine can be decreased when combined with Lovastatin.
Dapsone Dapsone The metabolism of Dapsone can be decreased when combined with Lovastatin.
Sulfadiazine Sulfadiazine The metabolism of Sulfadiazine can be decreased when combined with Lovastatin.
Oxycodone Oxycodone The metabolism of Oxycodone can be decreased when combined with Lovastatin.
Methadone Methadone The metabolism of Lovastatin can be decreased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Lovastatin can be decreased when combined with Oxybutynin.
Benztropine Benztropine The metabolism of Benzatropine can be decreased when combined with Lovastatin.
Colestipol Colestipol Colestipol can cause a decrease in the absorption of Lovastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Maprotiline Maprotiline The metabolism of Maprotiline can be decreased when combined with Lovastatin.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Lovastatin.
Orphenadrine Orphenadrine The metabolism of Lovastatin can be decreased when combined with Orphenadrine.
Perphenazine Perphenazine The metabolism of Perphenazine can be decreased when combined with Lovastatin.
Phentermine Phentermine The metabolism of Phentermine can be decreased when combined with Lovastatin.
Amoxapine Amoxapine The metabolism of Amoxapine can be decreased when combined with Lovastatin.
Sulfasalazine Sulfasalazine The excretion of Lovastatin can be decreased when combined with Sulfasalazine.
Hydrocortisone Hydrocortisone The metabolism of Lovastatin can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Lovastatin can be decreased when combined with Doxorubicin.
Cytarabine Cytarabine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Cytarabine.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Lovastatin.
Methyldopa Methyldopa The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Methyldopa.
Clonidine Clonidine The metabolism of Clonidine can be decreased when combined with Lovastatin.
Hydralazine Hydralazine The metabolism of Lovastatin can be decreased when combined with Hydralazine.
Cimetidine Cimetidine The metabolism of Lovastatin can be decreased when combined with Cimetidine.
Warfarin Warfarin The serum concentration of Warfarin can be increased when it is combined with Lovastatin.
Loperamide Loperamide The serum concentration of Lovastatin can be increased when it is combined with Loperamide.
Promethazine Promethazine The metabolism of Promethazine can be decreased when combined with Lovastatin.
Daunorubicin Daunorubicin The metabolism of Lovastatin can be decreased when combined with Daunorubicin.
Nitrofurantoin Nitrofurantoin Lovastatin may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Lovastatin can be increased when combined with Griseofulvin.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Lovastatin.
Quinine Quinine The metabolism of Lovastatin can be decreased when combined with Quinine.
Sulfinpyrazone Sulfinpyrazone The metabolism of Lovastatin can be decreased when combined with Sulfinpyrazone.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Lovastatin.
Secobarbital Secobarbital The metabolism of Lovastatin can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Lovastatin can be decreased when combined with Desipramine.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Lovastatin.
Imipramine Imipramine The metabolism of Imipramine can be decreased when combined with Lovastatin.
Probenecid Probenecid The metabolism of Lovastatin can be increased when combined with Probenecid.
Quinidine Quinidine The metabolism of Lovastatin can be decreased when combined with Quinidine.
Procainamide Procainamide The metabolism of Procainamide can be decreased when combined with Lovastatin.
Isoniazid Isoniazid The metabolism of Lovastatin can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Lovastatin can be increased when combined with Rifampicin.
Valproic Acid Valproic Acid The metabolism of Lovastatin can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Lovastatin can be decreased when combined with Tamoxifen.
Levothyroxine Levothyroxine The metabolism of Lovastatin can be decreased when combined with Levothyroxine.
Liothyronine Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Lovastatin.
Methimazole Methimazole The serum concentration of Lovastatin can be increased when it is combined with Methimazole.
Propylthiouracil Propylthiouracil The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Propylthiouracil.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Lovastatin.
Tolazamide Tolazamide The metabolism of Tolazamide can be decreased when combined with Lovastatin.
Dextromethorphan Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Lovastatin.
Dinoprostone Dinoprostone The excretion of Dinoprostone can be decreased when combined with Lovastatin.
Baclofen Baclofen The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Baclofen is combined with Lovastatin.
Chlorpheniramine Chlorpheniramine The metabolism of Chlorpheniramine can be decreased when combined with Lovastatin.
Meclizine Meclizine The metabolism of Meclizine can be decreased when combined with Lovastatin.
Chlorzoxazone Chlorzoxazone The metabolism of Chlorzoxazone can be decreased when combined with Lovastatin.
Danazol Danazol The serum concentration of Lovastatin can be increased when it is combined with Danazol.
Disulfiram Disulfiram Lovastatin may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Lovastatin.
Spironolactone Spironolactone The metabolism of Lovastatin can be decreased when combined with Spironolactone.
Amphotericin B Injection Amphotericin B Injection The metabolism of Lovastatin can be decreased when combined with Amphotericin B.
Nadolol Nadolol The metabolism of Nadolol can be decreased when combined with Lovastatin.
Cholestyramine Resin Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Lovastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be decreased when combined with Lovastatin.
Colchicine Colchicine The metabolism of Colchicine can be decreased when combined with Lovastatin.
Cefaclor Cefaclor Lovastatin may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Cephalexin Cephalexin The metabolism of Cephalexin can be decreased when combined with Lovastatin.
Acetazolamide Acetazolamide The metabolism of Lovastatin can be decreased when combined with Acetazolamide.
Nystatin Nystatin The excretion of Lovastatin can be decreased when combined with Nystatin.
Calcitonin Salmon Injection Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Lovastatin.
Ketoconazole Ketoconazole The serum concentration of Lovastatin can be increased when it is combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Lovastatin.
Vincristine Injection Vincristine Injection The metabolism of Lovastatin can be decreased when combined with Vincristine.
Captopril Captopril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Captopril.
Dipyridamole Dipyridamole Dipyridamole may decrease the excretion rate of Lovastatin which could result in a higher serum level.
Vinblastine Vinblastine The metabolism of Lovastatin can be decreased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Lovastatin.
Hydroxyzine Hydroxyzine The metabolism of Hydroxyzine can be decreased when combined with Lovastatin.
Aspirin Aspirin The metabolism of Acetylsalicylic acid can be decreased when combined with Lovastatin.
Alprazolam Alprazolam The metabolism of Alprazolam can be decreased when combined with Lovastatin.
Triazolam Triazolam The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Triazolam.
Trimethoprim Trimethoprim The metabolism of Trimethoprim can be decreased when combined with Lovastatin.
Diltiazem Diltiazem The serum concentration of Lovastatin can be increased when it is combined with Diltiazem.
Nifedipine Nifedipine Nifedipine may decrease the excretion rate of Lovastatin which could result in a higher serum level.
Timolol Timolol The metabolism of Timolol can be decreased when combined with Lovastatin.
Verapamil Verapamil The risk or severity of myopathy and rhabdomyolysis can be increased when Verapamil is combined with Lovastatin.
Atenolol Atenolol Lovastatin may decrease the excretion rate of Atenolol which could result in a higher serum level.
Pindolol Pindolol The metabolism of Pindolol can be decreased when combined with Lovastatin.
Piroxicam Piroxicam The metabolism of Piroxicam can be decreased when combined with Lovastatin.
Bumetanide Bumetanide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Bumetanide.
Etoposide Etoposide The metabolism of Lovastatin can be decreased when combined with Etoposide.
Glyburide Glyburide The metabolism of Lovastatin can be decreased when combined with Glyburide.
Pentamidine Injection Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Lovastatin.
Labetalol Labetalol The metabolism of Labetalol can be decreased when combined with Lovastatin.
Leuprolide Injection Leuprolide Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leuprolide is combined with Lovastatin.
Gemfibrozil Gemfibrozil The risk or severity of rhabdomyolysis, myoglobinuria, and elevated creatine kinase (CPK) can be increased when Gemfibrozil is combined with Lovastatin.
Ketoprofen Ketoprofen The metabolism of Ketoprofen can be decreased when combined with Lovastatin.
Pimozide Pimozide The metabolism of Lovastatin can be decreased when combined with Pimozide.
Enalapril Enalapril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Enalapril.
Flurbiprofen Flurbiprofen The metabolism of Lovastatin can be decreased when combined with Flurbiprofen.
Amiodarone Amiodarone The serum concentration of Lovastatin can be increased when it is combined with Amiodarone.
Buspirone Buspirone The metabolism of Buspirone can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Lovastatin can be decreased when combined with Ciprofloxacin.
Diclofenac Diclofenac The metabolism of Lovastatin can be decreased when combined with Diclofenac.
Fluoxetine Fluoxetine The metabolism of Fluoxetine can be decreased when combined with Lovastatin.
Clozapine Clozapine The metabolism of Lovastatin can be decreased when combined with Clozapine.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Lovastatin.
Ofloxacin Ofloxacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Ofloxacin.
Clarithromycin Clarithromycin The risk or severity of myopathy and rhabdomyolysis can be increased when Clarithromycin is combined with Lovastatin.
Etodolac Etodolac The metabolism of Etodolac can be decreased when combined with Lovastatin.
Felodipine Felodipine The metabolism of Lovastatin can be decreased when combined with Felodipine.
Nabumetone Nabumetone The metabolism of Nabumetone can be decreased when combined with Lovastatin.
Pravastatin Pravastatin Lovastatin may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Lovastatin.
Teniposide Injection Teniposide Injection The metabolism of Lovastatin can be decreased when combined with Teniposide.
Itraconazole Itraconazole The serum concentration of Lovastatin can be increased when it is combined with Itraconazole.
Rifabutin Rifabutin The metabolism of Lovastatin can be increased when combined with Rifabutin.
Sotalol Sotalol The metabolism of Sotalol can be decreased when combined with Lovastatin.
Zolpidem Zolpidem The metabolism of Zolpidem can be decreased when combined with Lovastatin.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Lovastatin.
Isradipine Isradipine The metabolism of Lovastatin can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Lovastatin can be decreased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Cisapride can be decreased when combined with Lovastatin.
Fluvastatin Fluvastatin The metabolism of Lovastatin can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The metabolism of Lovastatin can be decreased when combined with Venlafaxine.
Nizatidine Nizatidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Nizatidine.
Stavudine Stavudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Stavudine.
Famciclovir Famciclovir The metabolism of Famciclovir can be decreased when combined with Lovastatin.
Fluvoxamine Fluvoxamine The metabolism of Lovastatin can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The serum concentration of Lovastatin can be increased when it is combined with Nefazodone.
Lamotrigine Lamotrigine The metabolism of Lovastatin can be increased when combined with Lamotrigine.
Losartan Losartan The metabolism of Lovastatin can be decreased when combined with Losartan.
Tramadol Tramadol The metabolism of Lovastatin can be decreased when combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Lovastatin.
Lansoprazole Lansoprazole The metabolism of Lovastatin can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Lovastatin can be decreased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Lovastatin can be decreased when combined with Nicardipine.
Bupropion Bupropion The metabolism of Bupropion can be decreased when combined with Lovastatin.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Lovastatin.
Saquinavir Saquinavir The serum concentration of Lovastatin can be increased when it is combined with Saquinavir.
Metformin Metformin Metformin may increase the hypolipidaemic activities of Lovastatin.
Nisoldipine Nisoldipine The metabolism of Nisoldipine can be decreased when combined with Lovastatin.
Lamivudine Lamivudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Lamivudine.
Glimepiride Glimepiride The metabolism of Glimepiride can be decreased when combined with Lovastatin.
Anastrozole Anastrozole The metabolism of Anastrozole can be decreased when combined with Lovastatin.
Indinavir Indinavir The metabolism of Lovastatin can be decreased when combined with Indinavir.
Ritonavir Ritonavir The serum concentration of Lovastatin can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Lovastatin can be decreased when combined with Docetaxel.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Lovastatin.
Zafirlukast Zafirlukast The metabolism of Lovastatin can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The metabolism of Lovastatin can be decreased when combined with Mirtazapine.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Lovastatin.
Valsartan Valsartan The metabolism of Valsartan can be decreased when combined with Lovastatin.
Donepezil Donepezil The metabolism of Lovastatin can be decreased when combined with Donepezil.
Nelfinavir Nelfinavir The serum concentration of Lovastatin can be increased when it is combined with Nelfinavir.
Fexofenadine Fexofenadine The excretion of Fexofenadine can be decreased when combined with Lovastatin.
Azithromycin Azithromycin The metabolism of Azithromycin can be decreased when combined with Lovastatin.
Loratadine Loratadine The metabolism of Lovastatin can be decreased when combined with Loratadine.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Lovastatin.
Nilutamide Nilutamide The metabolism of Lovastatin can be decreased when combined with Nilutamide.
Flutamide Flutamide The metabolism of Flutamide can be decreased when combined with Lovastatin.
Selegiline Selegiline The metabolism of Selegiline can be decreased when combined with Lovastatin.
Bicalutamide Bicalutamide The metabolism of Lovastatin can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Sertraline can be decreased when combined with Lovastatin.
Propafenone Propafenone The metabolism of Propafenone can be decreased when combined with Lovastatin.
Letrozole Letrozole The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Lovastatin is combined with Letrozole.
Raloxifene Raloxifene The metabolism of Lovastatin can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Lovastatin can be decreased when combined with Irbesartan.
Tamsulosin Tamsulosin The metabolism of Tamsulosin can be decreased when combined with Lovastatin.
Finasteride Finasteride The metabolism of Finasteride can be decreased when combined with Lovastatin.
Quetiapine Quetiapine The metabolism of Quetiapine can be decreased when combined with Lovastatin.
Paroxetine Paroxetine The metabolism of Lovastatin can be decreased when combined with Paroxetine.
Citalopram Citalopram The metabolism of Lovastatin can be decreased when combined with Citalopram.
Capecitabine Capecitabine The metabolism of Capecitabine can be decreased when combined with Lovastatin.
Efavirenz Efavirenz The serum concentration of Lovastatin can be decreased when it is combined with Efavirenz.
Sildenafil Sildenafil The metabolism of Lovastatin can be decreased when combined with Sildenafil.
Pioglitazone Pioglitazone The metabolism of Pioglitazone can be decreased when combined with Lovastatin.
Celecoxib Celecoxib The metabolism of Lovastatin can be decreased when combined with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Lovastatin can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Lovastatin.
Thalidomide Thalidomide The metabolism of Lovastatin can be increased when combined with Thalidomide.
Colesevelam Colesevelam Colesevelam can cause a decrease in the absorption of Lovastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Lovastatin.
Galantamine Galantamine The metabolism of Galantamine can be decreased when combined with Lovastatin.
Rabeprazole Rabeprazole The metabolism of Lovastatin can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Terbinafine can be decreased when combined with Lovastatin.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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