Pravastatin

Generic name: Pronounced as (pra' va stat in)
Brand names
  • Pravachol®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 11/15/2017

[Posted 07/20/2021]

AUDIENCE: Patient, Health Professional, OBGYN, Cardiology, Endocrinology, Pharmacy

ISSUE: The FDA is requesting revisions to the information about use in pregnancy in the prescribing information of the entire class of statin medicines. These changes include removing the contraindication against using these medicines in all pregnant patients. A contraindication is FDA's strongest warning and is only added when a medicine should not be used because the risk clearly outweighs any possible benefit. Because the benefits of statins may include prevention of serious or potentially fatal events in a small group of very high-risk pregnant patients, contraindicating these drugs in all pregnant women is not appropriate.

FDA expects removing the contraindication will enable health care professionals and patients to make individual decisions about benefit and risk, especially for those at very high risk of heart attack or stroke. This includes patients with homozygous familial hypercholesterolemia and those who have previously had a heart attack or stroke.

BACKGROUND: Statins are a class of prescription medicines that have been used for decades to lower low-density lipoprotein (LDL-C or "bad") cholesterol in the blood. Medicines in the statin class include atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin.

RECOMMENDATIONS:

  • Patients: Patients taking statins should notify their health care professionals if they become pregnant or suspect they are pregnant. Your health care professional will be able to advise whether you should stop taking the medicine during pregnancy and whether you may stop your statin temporarily while breastfeeding. Patients who are at high risk of heart attack or stroke who require statins after giving birth should not breastfeed and should use alternatives such as infant formula.

  • Health Care Professionals: Health care professionals should discontinue statin therapy in most pregnant patients, or they can consider the ongoing therapeutic needs of the individual patient, particularly those at very high risk for cardiovascular events during pregnancy. Because of the chronic nature of cardiovascular disease, treatment of hyperlipidemia is not generally necessary during pregnancy. Discuss with patients whether they may discontinue statins temporarily while breastfeeding. Advise those who require a statin because of their cardiovascular risk that breastfeeding is not recommended because the medicine may pass into breast milk

The FDA hopes the revised language in the prescribing information will help reassure health care professionals that statins are safe to prescribe in patients who can become pregnant, and help them reassure patients with unintended statin exposure in early pregnancy or before pregnancy is recognized that the medicine is unlikely to harm the unborn baby.

For more information visit the FDA website at: http://www.fda.gov/Safety/MedWatch/SafetyInformation and http://www.fda.gov/Drugs/DrugSafety.

Pravastatin is used together with diet, weight-loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. Pravastatin is also used to reduce the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol ('bad cholesterol') and triglycerides in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol ('good cholesterol') in the blood. Pravastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. Lowering your blood level of cholesterol and fats with pravastatin has been shown to prevent heart disease, angina (chest pain), strokes, and heart attacks.

Pravastatin comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take pravastatin at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take pravastatin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may start you on a low dose of pravastatin and gradually increase your dose, not more than once every 4 weeks.

Continue to take pravastatin even if you feel well. Do not stop taking pravastatin without talking to your doctor.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking pravastatin,

  • tell your doctor and pharmacist if you are allergic to pravastatin, any other medications, or any of the ingredients in pravastatin tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antacids; antifungals such as fluconazole (Diflucan) and ketoconazole (Nizoral); boceprevir (Victrelis); cimetidine (Tagamet); clarithromycin (Biaxin); colchicine (Colcrys); cyclosporine (Neoral, Sandimmune); digoxin (Lanoxin); diltiazem (Cardizem, Cartia, Taztia, Tiazac); erythromycin (E.E.S., E-Mycin, Erythrocin); other cholesterol-lowering medications such as fenofibrate (Tricor), gemfibrozil (Lopid), and niacin (nicotinic acid, Niacor, Niaspan); ritonavir (Norvir) taken with darunavir (Prezista); spironolactone (Aldactone); verapamil (Calan, Covera, Verelan); and warfarin (Coumadin). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Other medications may also interact with pravastatin, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • if you are taking cholestyramine (Questran) or colestipol (Colestid), take them 4 hours before or 1 hour after pravastatin.

  • tell your doctor if you have liver disease. Your doctor will order laboratory tests to see how well your liver is working even if you do not think you have liver disease. Your doctor will probably tell you not to take pravastatin if you have liver disease or if the tests show that you may be developing liver disease.

  • tell your doctor if you drink more than two alcoholic beverages per day, if you are 65 years of age or older, if you have ever had liver disease or if you have or have ever had low blood pressure, muscle aches or weakness, seizures, or thyroid or kidney disease.

  • tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are taking pravastatin. Talk to your doctor about birth control methods that you can use during your treatment. If you become pregnant while taking pravastatin, stop taking pravastatin and call your doctor immediately. Pravastatin may harm the fetus.

  • do not breastfeed while you are taking this medication.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking pravastatin. If you are hospitalized due to serious injury or infection, tell the doctor who treats you that you are taking pravastatin.

  • ask your doctor about the safe use of alcoholic beverages while you are taking pravastatin. Alcohol can increase the risk of serious side effects.

Eat a low-fat, low-cholesterol diet. Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. You can also visit the National Cholesterol Education Program (NCEP) website for additional dietary information at http://www.nhlbi.nih.gov/health/public/heart/chol/chol_tlc.pdf.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue the regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Pravastatin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • heartburn

    • headache

    • memory loss or forgetfulness

    • confusion

  • Some side effects can be serious. If you experience any of the following side effects, call your doctor immediately or get emergency medical help:

    • muscle pain, tenderness, or weakness

    • lack of energy

    • fever

    • yellowing of the skin or eyes

    • pain in the upper right part of the stomach

    • nausea

    • extreme tiredness

    • weakness

    • unusual bleeding or bruising

    • dark colored urine

    • loss of appetite

    • flu-like symptoms

    • rash

    • hives

    • itching

    • difficulty breathing or swallowing

    • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

    • hoarseness

  • Pravastatin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor may order lab tests during your treatment, especially if you develop symptoms of liver damage.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking pravastatin.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide Pravastatin may decrease the excretion rate of Repaglinide which could result in a higher serum level.
Montelukast Montelukast The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Montelukast.
Leflunomide Leflunomide Pravastatin may decrease the excretion rate of Leflunomide which could result in a higher serum level.
Atorvastatin Atorvastatin Atorvastatin may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Alendronate Alendronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Alendronic acid.
Candesartan Candesartan The excretion of Pravastatin can be decreased when combined with Candesartan.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The risk or severity of myopathy and rhabdomyolysis can be increased when Erythromycin is combined with Pravastatin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Pravastatin may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Nafarelin Nafarelin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Nafarelin.
Paregoric Paregoric The serum concentration of Morphine can be increased when it is combined with Pravastatin.
Ranitidine Ranitidine The excretion of Ranitidine can be decreased when combined with Pravastatin.
Reserpine Reserpine Reserpine may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Sumatriptan Sumatriptan Pravastatin may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus Tacrolimus The serum concentration of Pravastatin can be increased when it is combined with Tacrolimus.
Triamcinolone Triamcinolone The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Triamcinolone.
Famotidine Injection Famotidine Injection The excretion of Famotidine can be decreased when combined with Pravastatin.
Fluconazole Injection Fluconazole Injection The serum concentration of Pravastatin can be increased when it is combined with Fluconazole.
Levofloxacin Injection Levofloxacin Injection The excretion of Levofloxacin can be decreased when combined with Pravastatin.
Metoclopramide Injection Metoclopramide Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Metoclopramide.
Morphine Injection Morphine Injection The serum concentration of Morphine can be increased when it is combined with Pravastatin.
Pamidronate Injection Pamidronate Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Pamidronic acid.
Zidovudine Injection Zidovudine Injection Pravastatin may decrease the excretion rate of Zidovudine which could result in a higher serum level.
Cyclosporine Cyclosporine The serum concentration of Pravastatin can be increased when it is combined with Cyclosporine.
Eprosartan Eprosartan The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Eprosartan.
Pantoprazole Pantoprazole The excretion of Pravastatin can be decreased when combined with Pantoprazole.
Risedronate Risedronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Risedronic acid.
Sevelamer Sevelamer Sevelamer can cause a decrease in the absorption of Pravastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Telmisartan Telmisartan Telmisartan may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Trimipramine Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Pravastatin.
Tenofovir Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Pravastatin.
Sirolimus Sirolimus The serum concentration of Pravastatin can be increased when it is combined with Sirolimus.
Olmesartan Olmesartan Olmesartan may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Zonisamide Zonisamide The serum concentration of Pravastatin can be increased when it is combined with Zonisamide.
Ezetimibe Ezetimibe Pravastatin may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Atazanavir Atazanavir Atazanavir may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Mefloquine Mefloquine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Mefloquine.
Rosuvastatin Rosuvastatin Pravastatin may decrease the excretion rate of Rosuvastatin which could result in a higher serum level.
Vardenafil Vardenafil The serum concentration of Pravastatin can be increased when it is combined with Vardenafil.
Tegaserod Tegaserod Pravastatin may decrease the excretion rate of Tegaserod which could result in a higher serum level.
Progesterone Progesterone Progesterone may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Infliximab Injection Infliximab Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Infliximab is combined with Pravastatin.
Tinidazole Tinidazole Pravastatin may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Bosentan Bosentan The serum concentration of Pravastatin can be decreased when it is combined with Bosentan.
Cefditoren Cefditoren The excretion of Cefdinir can be decreased when combined with Pravastatin.
Erlotinib Erlotinib The metabolism of Pravastatin can be decreased when combined with Erlotinib.
Ganciclovir Ganciclovir The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Ganciclovir.
Ibandronate Ibandronate The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Ibandronate.
Tipranavir Tipranavir Tipranavir may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Ranolazine Ranolazine The serum concentration of Pravastatin can be increased when it is combined with Ranolazine.
Imatinib Imatinib Pravastatin may decrease the excretion rate of Imatinib which could result in a higher serum level.
Sitagliptin Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Pravastatin.
Gefitinib Gefitinib Pravastatin may decrease the excretion rate of Gefitinib which could result in a higher serum level.
Paliperidone Paliperidone The serum concentration of Pravastatin can be increased when it is combined with Paliperidone.
Bortezomib Bortezomib The serum concentration of Bortezomib can be increased when it is combined with Pravastatin.
Clofarabine Injection Clofarabine Injection The excretion of Clofarabine can be decreased when combined with Pravastatin.
Oxaliplatin Injection Oxaliplatin Injection Pravastatin may decrease the excretion rate of Oxaliplatin which could result in a higher serum level.
Posaconazole Posaconazole The serum concentration of Posaconazole can be increased when it is combined with Pravastatin.
Darunavir Darunavir The serum concentration of Pravastatin can be increased when it is combined with Darunavir.
Pemetrexed Injection Pemetrexed Injection The excretion of Pemetrexed can be decreased when combined with Pravastatin.
Sorafenib Sorafenib The serum concentration of Pravastatin can be increased when it is combined with Sorafenib.
Sunitinib Sunitinib Sunitinib may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Dronabinol Dronabinol Dronabinol may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Lapatinib Lapatinib The serum concentration of Pravastatin can be increased when it is combined with Lapatinib.
Dasatinib Dasatinib Pravastatin may decrease the excretion rate of Dasatinib which could result in a higher serum level.
Ivermectin Ivermectin Pravastatin may decrease the excretion rate of Ivermectin which could result in a higher serum level.
Temsirolimus Temsirolimus The serum concentration of Pravastatin can be increased when it is combined with Temsirolimus.
Nilotinib Nilotinib The serum concentration of Pravastatin can be increased when it is combined with Nilotinib.
Toremifene Toremifene The serum concentration of Pravastatin can be increased when it is combined with Toremifene.
Raltegravir Raltegravir The risk or severity of myopathy and rhabdomyolysis can be increased when Raltegravir is combined with Pravastatin.
Budesonide Budesonide Pravastatin may decrease the excretion rate of Budesonide which could result in a higher serum level.
Doripenem Injection Doripenem Injection The excretion of Doripenem can be decreased when combined with Pravastatin.
Mitoxantrone Injection Mitoxantrone Injection Pravastatin may decrease the excretion rate of Mitoxantrone which could result in a higher serum level.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Pravastatin.
Leucovorin Injection Leucovorin Injection The excretion of Leucovorin can be decreased when combined with Pravastatin.
Irinotecan Injection Irinotecan Injection Pravastatin may decrease the excretion rate of Irinotecan which could result in a higher serum level.
Daptomycin Injection Daptomycin Injection The risk or severity of myopathy can be increased when Pravastatin is combined with Daptomycin.
Silodosin Silodosin The serum concentration of Silodosin can be increased when it is combined with Pravastatin.
Naltrexone Injection Naltrexone Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Naltrexone.
Eltrombopag Eltrombopag Eltrombopag may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Everolimus Everolimus The serum concentration of Pravastatin can be increased when it is combined with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Pravastatin.
Dronedarone Dronedarone The serum concentration of Pravastatin can be increased when it is combined with Dronedarone.
Pralatrexate Injection Pralatrexate Injection Pravastatin may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Saxagliptin Saxagliptin The excretion of Saxagliptin can be decreased when combined with Pravastatin.
Romidepsin Injection Romidepsin Injection The serum concentration of Romidepsin can be increased when it is combined with Pravastatin.
Topotecan Topotecan Pravastatin may decrease the excretion rate of Topotecan which could result in a higher serum level.
Pazopanib Pazopanib Pravastatin may increase the hepatotoxic activities of Pazopanib.
Pitavastatin Pitavastatin Pravastatin may decrease the excretion rate of Pitavastatin which could result in a higher serum level.
Cabazitaxel Injection Cabazitaxel Injection Cabazitaxel may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Linagliptin Linagliptin The serum concentration of Pravastatin can be increased when it is combined with Linagliptin.
Rilpivirine Rilpivirine Rilpivirine may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Telaprevir Telaprevir The serum concentration of Pravastatin can be increased when it is combined with Glecaprevir.
Rivaroxaban Rivaroxaban Pravastatin may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor Ticagrelor The serum concentration of Pravastatin can be increased when it is combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Pravastatin.
Vandetanib Vandetanib Vandetanib may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Clobazam Clobazam The serum concentration of Clobazam can be increased when it is combined with Pravastatin.
Vemurafenib Vemurafenib The serum concentration of Pravastatin can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib Vismodegib may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Ivacaftor Ivacaftor The serum concentration of Pravastatin can be increased when it is combined with Ivacaftor.
Axitinib Axitinib The serum concentration of Pravastatin can be increased when it is combined with Axitinib.
Crizotinib Crizotinib The serum concentration of Pravastatin can be increased when it is combined with Crizotinib.
Cabergoline Cabergoline The serum concentration of Cabergoline can be increased when it is combined with Pravastatin.
Ambrisentan Ambrisentan The serum concentration of Ambrisentan can be increased when it is combined with Pravastatin.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Pravastatin can be increased when it is combined with Carfilzomib.
Iloprost Iloprost The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Iloprost.
Enzalutamide Enzalutamide The serum concentration of Pravastatin can be increased when it is combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Pravastatin.
Regorafenib Regorafenib The serum concentration of Pravastatin can be increased when it is combined with Regorafenib.
Bosutinib Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Pravastatin.
Teriflunomide Teriflunomide Pravastatin may decrease the excretion rate of Teriflunomide which could result in a higher serum level.
Ponatinib Ponatinib The serum concentration of Pravastatin can be increased when it is combined with Ponatinib.
Pomalidomide Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Pravastatin.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be increased when it is combined with Pravastatin.
Apixaban Apixaban Pravastatin may decrease the excretion rate of Apixaban which could result in a higher serum level.
Canagliflozin Canagliflozin The serum concentration of Pravastatin can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib Pravastatin may decrease the excretion rate of Dabrafenib which could result in a higher serum level.
Dolutegravir Dolutegravir Pravastatin may decrease the excretion rate of Dolutegravir which could result in a higher serum level.
Afatinib Afatinib The serum concentration of Pravastatin can be increased when it is combined with Afatinib.
Lomitapide Lomitapide The serum concentration of Pravastatin can be increased when it is combined with Lomitapide.
Simeprevir Simeprevir The serum concentration of Pravastatin can be increased when it is combined with Simeprevir.
Sofosbuvir Sofosbuvir Pravastatin may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Ceritinib Ceritinib The serum concentration of Ceritinib can be increased when it is combined with Pravastatin.
Belinostat Injection Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Pravastatin.
Idelalisib Idelalisib Pravastatin may decrease the excretion rate of Idelalisib which could result in a higher serum level.
Testosterone Injection Testosterone Injection Pravastatin may decrease the excretion rate of Testosterone which could result in a higher serum level.
Vorapaxar Vorapaxar The serum concentration of Pravastatin can be increased when it is combined with Vorapaxar.
Suvorexant Suvorexant The serum concentration of Pravastatin can be increased when it is combined with Suvorexant.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Pravastatin.
Olaparib Olaparib Olaparib may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Caspofungin Injection Caspofungin Injection The excretion of Pravastatin can be decreased when combined with Caspofungin.
Riociguat Riociguat Pravastatin may decrease the excretion rate of Riociguat which could result in a higher serum level.
Nintedanib Nintedanib The serum concentration of Nintedanib can be increased when it is combined with Pravastatin.
Palbociclib Palbociclib Pravastatin may decrease the excretion rate of Palbociclib which could result in a higher serum level.
Lenvatinib Lenvatinib Lenvatinib may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Panobinostat Panobinostat The serum concentration of Panobinostat can be increased when it is combined with Pravastatin.
Deoxycholic Acid Injection Deoxycholic Acid Injection Deoxycholic acid may increase the excretion rate of Pravastatin which could result in a lower serum level and potentially a reduction in efficacy.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Pravastatin can be increased when it is combined with Isavuconazonium.
Flibanserin Flibanserin The serum concentration of Pravastatin can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant The serum concentration of Pravastatin can be increased when it is combined with Rolapitant.
Daclatasvir Daclatasvir The serum concentration of Pravastatin can be increased when it is combined with Daclatasvir.
Eluxadoline Eluxadoline The excretion of Eluxadoline can be decreased when combined with Pravastatin.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Pravastatin.
Trabectedin Injection Trabectedin Injection The risk or severity of myopathy and rhabdomyolysis can be increased when Pravastatin is combined with Trabectedin.
Osimertinib Osimertinib Pravastatin may decrease the excretion rate of Osimertinib which could result in a higher serum level.
Alectinib Alectinib Alectinib may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection Dexamethasone may increase the excretion rate of Pravastatin which could result in a lower serum level and potentially a reduction in efficacy.
Venetoclax Venetoclax The serum concentration of Pravastatin can be increased when it is combined with Venetoclax.
Cobicistat Cobicistat Cobicistat may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Selexipag Selexipag The serum concentration of Selexipag can be increased when it is combined with Pravastatin.
Furosemide Injection Furosemide Injection The excretion of Pravastatin can be decreased when combined with Furosemide.
Rucaparib Rucaparib The serum concentration of Pravastatin can be increased when it is combined with Rucaparib.
Brigatinib Brigatinib Pravastatin may decrease the excretion rate of Brigatinib which could result in a higher serum level.
Safinamide Safinamide Safinamide may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Edaravone Injection Edaravone Injection The excretion of Edaravone can be decreased when combined with Pravastatin.
Neratinib Neratinib The serum concentration of Pravastatin can be increased when it is combined with Neratinib.
Enasidenib Enasidenib The serum concentration of Pravastatin can be increased when it is combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Pravastatin.
Copanlisib Injection Copanlisib Injection Pravastatin may decrease the excretion rate of Copanlisib which could result in a higher serum level.
Delafloxacin Delafloxacin Pravastatin may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Abemaciclib Abemaciclib Pravastatin may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Pravastatin.
Letermovir Letermovir Letermovir may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Ertugliflozin Ertugliflozin Pravastatin may decrease the excretion rate of Ertugliflozin which could result in a higher serum level.
Buprenorphine Injection Buprenorphine Injection Buprenorphine may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Apalutamide Apalutamide The serum concentration of Pravastatin can be decreased when it is combined with Apalutamide.
Penicillamine Penicillamine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Penicillamine.
Fostamatinib Fostamatinib Fostamatinib may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Avatrombopag Avatrombopag Avatrombopag may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Baricitinib Baricitinib Baricitinib may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Eliglustat Eliglustat The serum concentration of Eliglustat can be increased when it is combined with Pravastatin.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Pravastatin.
Ivosidenib Ivosidenib The serum concentration of Pravastatin can be increased when it is combined with Ivosidenib.
Lusutrombopag Lusutrombopag Pravastatin may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Pravastatin.
Cannabidiol Cannabidiol Cannabidiol may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Dacomitinib Dacomitinib Pravastatin may decrease the excretion rate of Dacomitinib which could result in a higher serum level.
Duvelisib Duvelisib Pravastatin may decrease the excretion rate of Duvelisib which could result in a higher serum level.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Pravastatin.
Sarecycline Sarecycline The serum concentration of Pravastatin can be increased when it is combined with Sarecycline.
Talazoparib Talazoparib Pravastatin may decrease the excretion rate of Talazoparib which could result in a higher serum level.
Gilteritinib Gilteritinib Gilteritinib may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Glasdegib Glasdegib Pravastatin may decrease the excretion rate of Glasdegib which could result in a higher serum level.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Pravastatin.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection Pravastatin may decrease the excretion rate of Paclitaxel which could result in a higher serum level.
Rifamycin Rifamycin The serum concentration of Pravastatin can be increased when it is combined with Rifamycin.
Acyclovir Ophthalmic Acyclovir Ophthalmic The excretion of Acyclovir can be decreased when combined with Pravastatin.
Erdafitinib Erdafitinib The serum concentration of Pravastatin can be increased when it is combined with Erdafitinib.
Esomeprazole Injection Esomeprazole Injection The excretion of Pravastatin can be decreased when combined with Esomeprazole.
Alpelisib Alpelisib The serum concentration of Alpelisib can be increased when it is combined with Pravastatin.
Cladribine Cladribine Pravastatin may decrease the excretion rate of Cladribine which could result in a higher serum level.
Selinexor Selinexor The excretion of Pravastatin can be decreased when combined with Selinexor.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Pravastatin.
Entrectinib Entrectinib The serum concentration of Pravastatin can be increased when it is combined with Entrectinib.
Pexidartinib Pexidartinib The excretion of Pravastatin can be decreased when combined with Pexidartinib.
Istradefylline Istradefylline Istradefylline may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Pitolisant Pitolisant The serum concentration of Pravastatin can be increased when it is combined with Pitolisant.
Fedratinib Fedratinib Fedratinib may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Lefamulin Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Pravastatin.
Phenytoin Injection Phenytoin Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Phenytoin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Pravastatin.
Lasmiditan Lasmiditan The serum concentration of Pravastatin can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Pravastatin.
Tazemetostat Tazemetostat Pravastatin may decrease the excretion rate of Tazemetostat which could result in a higher serum level.
Bempedoic Acid Bempedoic Acid The risk or severity of myopathy can be increased when Bempedoic acid is combined with Pravastatin.
Ozanimod Ozanimod Pravastatin may decrease the excretion rate of Ozanimod which could result in a higher serum level.
Selumetinib Selumetinib Pravastatin may decrease the excretion rate of Selumetinib which could result in a higher serum level.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Pravastatin.
Tucatinib Tucatinib Pravastatin may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Remdesivir Injection Remdesivir Injection The serum concentration of Pravastatin can be increased when it is combined with Remdesivir.
Ripretinib Ripretinib Pravastatin may decrease the excretion rate of Ripretinib which could result in a higher serum level.
Capmatinib Capmatinib The serum concentration of Pravastatin can be increased when it is combined with Capmatinib.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Pravastatin.
Fostemsavir Fostemsavir The serum concentration of Pravastatin can be increased when it is combined with Fostemsavir.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection Pravastatin may decrease the excretion rate of Belantamab mafodotin which could result in a higher serum level.
Pralsetinib Pralsetinib Pralsetinib may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Cabotegravir Cabotegravir The excretion of Pravastatin can be decreased when combined with Cabotegravir.
Indomethacin Indomethacin The excretion of Pravastatin can be decreased when combined with Indomethacin.
Naproxen Naproxen Pravastatin may decrease the excretion rate of Naproxen which could result in a higher serum level.
Isotretinoin Isotretinoin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Isotretinoin.
Phenobarbital Phenobarbital Phenobarbital may increase the excretion rate of Pravastatin which could result in a lower serum level and potentially a reduction in efficacy.
Methotrexate Injection Methotrexate Injection Pravastatin may decrease the excretion rate of Methotrexate which could result in a higher serum level.
Chlorpromazine Chlorpromazine Chlorpromazine may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Procarbazine Procarbazine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Procarbazine.
Tetracycline Tetracycline The excretion of Tetracycline can be decreased when combined with Pravastatin.
Minocycline Minocycline The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Minocycline.
Colestipol Colestipol Colestipol can cause a decrease in the absorption of Pravastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ibuprofen Ibuprofen The excretion of Pravastatin can be decreased when combined with Ibuprofen.
Sulfasalazine Sulfasalazine Pravastatin may decrease the excretion rate of Sulfasalazine which could result in a higher serum level.
Hydrocortisone Hydrocortisone The excretion of Hydrocortisone can be decreased when combined with Pravastatin.
Doxorubicin Doxorubicin Pravastatin may decrease the excretion rate of Doxorubicin which could result in a higher serum level.
Cytarabine Cytarabine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Cytarabine.
Dactinomycin Dactinomycin Pravastatin may decrease the excretion rate of Dactinomycin which could result in a higher serum level.
Methyldopa Methyldopa The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Methyldopa.
Prazosin Prazosin Pravastatin may decrease the excretion rate of Prazosin which could result in a higher serum level.
Cimetidine Cimetidine Cimetidine may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Warfarin Warfarin The risk or severity of bleeding can be increased when Pravastatin is combined with Warfarin.
Loperamide Loperamide The serum concentration of Loperamide can be increased when it is combined with Pravastatin.
Daunorubicin Daunorubicin Pravastatin may decrease the excretion rate of Daunorubicin which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Pravastatin may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Digoxin Digoxin Pravastatin may decrease the excretion rate of Digoxin which could result in a higher serum level.
Loxapine Loxapine The serum concentration of Pravastatin can be increased when it is combined with Loxapine.
Chloroquine Chloroquine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Chloroquine.
Quinine Quinine The serum concentration of Pravastatin can be increased when it is combined with Quinine.
Sulfinpyrazone Sulfinpyrazone Pravastatin may decrease the excretion rate of Sulfinpyrazone which could result in a higher serum level.
Imipramine Imipramine The serum concentration of Imipramine can be increased when it is combined with Pravastatin.
Probenecid Probenecid The excretion of Pravastatin can be decreased when combined with Probenecid.
Quinidine Quinidine Quinidine may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Procainamide Procainamide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Procainamide.
Isoniazid Isoniazid The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Isoniazid.
Rifampin Rifampin Rifampicin may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Valproic Acid Valproic Acid The excretion of Valproic acid can be decreased when combined with Pravastatin.
Tamoxifen Tamoxifen Tamoxifen may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Levothyroxine Levothyroxine The excretion of Pravastatin can be decreased when combined with Levothyroxine.
Liothyronine Liothyronine The excretion of Pravastatin can be decreased when combined with Liothyronine.
Propylthiouracil Propylthiouracil The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Propylthiouracil.
Dinoprostone Dinoprostone The excretion of Dinoprostone can be decreased when combined with Pravastatin.
Niacin Niacin The risk or severity of myopathy and rhabdomyolysis can be increased when Niacin is combined with Pravastatin.
Baclofen Baclofen The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Baclofen.
Hydrochlorothiazide Hydrochlorothiazide The excretion of Hydrochlorothiazide can be decreased when combined with Pravastatin.
Folic Acid Folic Acid Pravastatin may decrease the excretion rate of Folic acid which could result in a higher serum level.
Danazol Danazol The serum concentration of Pravastatin can be increased when it is combined with Danazol.
Disulfiram Disulfiram Pravastatin may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Pravastatin can be increased when combined with Propranolol.
Nortriptyline Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Pravastatin.
Spironolactone Spironolactone Pravastatin may decrease the excretion rate of Spironolactone which could result in a higher serum level.
Amphotericin B Injection Amphotericin B Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Amphotericin B.
Mercaptopurine Mercaptopurine The excretion of Mercaptopurine can be decreased when combined with Pravastatin.
Cholestyramine Resin Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Pravastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Allopurinol Allopurinol Pravastatin may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Clomiphene Clomiphene The serum concentration of Clomifene can be increased when it is combined with Pravastatin.
Fluorouracil Injection Fluorouracil Injection Pravastatin may decrease the excretion rate of Fluorouracil which could result in a higher serum level.
Colchicine Colchicine Colchicine may increase the myopathic rhabdomyolysis activities of Pravastatin.
Cefaclor Cefaclor The excretion of Cefaclor can be decreased when combined with Pravastatin.
Cefadroxil Cefadroxil The excretion of Pravastatin can be decreased when combined with Cefadroxil.
Cefazolin Injection Cefazolin Injection The excretion of Cefazolin can be decreased when combined with Pravastatin.
Cephalexin Cephalexin The excretion of Cephalexin can be decreased when combined with Pravastatin.
Nystatin Nystatin The excretion of Pravastatin can be decreased when combined with Nystatin.
Cefotaxime Injection Cefotaxime Injection The excretion of Pravastatin can be decreased when combined with Cefotaxime.
Ketoconazole Ketoconazole The serum concentration of Pravastatin can be increased when it is combined with Ketoconazole.
Vincristine Injection Vincristine Injection Pravastatin may decrease the excretion rate of Vincristine which could result in a higher serum level.
Captopril Captopril The excretion of Captopril can be decreased when combined with Pravastatin.
Dipyridamole Dipyridamole Dipyridamole may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Vinblastine Vinblastine Vinblastine may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Aspirin Aspirin The excretion of Pravastatin can be decreased when combined with Acetylsalicylic acid.
Triazolam Triazolam The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Triazolam.
Trimethoprim Trimethoprim The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Trimethoprim.
Nifedipine Nifedipine Nifedipine may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Verapamil Verapamil The serum concentration of Pravastatin can be increased when it is combined with Verapamil.
Atenolol Atenolol Pravastatin may decrease the excretion rate of Atenolol which could result in a higher serum level.
Piroxicam Piroxicam The excretion of Pravastatin can be decreased when combined with Piroxicam.
Bumetanide Bumetanide The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Bumetanide.
Etoposide Etoposide Pravastatin may decrease the excretion rate of Etoposide which could result in a higher serum level.
Glyburide Glyburide Glyburide may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Glipizide Glipizide Pravastatin may decrease the excretion rate of Glipizide which could result in a higher serum level.
Ceftriaxone Injection Ceftriaxone Injection The excretion of Pravastatin can be decreased when combined with Ceftriaxone.
Leuprolide Injection Leuprolide Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Leuprolide is combined with Pravastatin.
Gemfibrozil Gemfibrozil The risk or severity of rhabdomyolysis, myoglobinuria, and elevated creatine kinase (CPK) can be increased when Gemfibrozil is combined with Pravastatin.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic The excretion of Adefovir dipivoxil can be decreased when combined with Pravastatin.
Ketoprofen Ketoprofen The excretion of Pravastatin can be decreased when combined with Ketoprofen.
Enalapril Enalapril The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Enalapril.
Amiodarone Amiodarone The metabolism of Pravastatin can be increased when combined with Amiodarone.
Lovastatin Lovastatin Lovastatin may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Ciprofloxacin Ciprofloxacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Ciprofloxacin.
Diclofenac Diclofenac The excretion of Pravastatin can be decreased when combined with Diclofenac.
Ofloxacin Ofloxacin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Ofloxacin.
Didanosine Didanosine The excretion of Didanosine can be decreased when combined with Pravastatin.
Clarithromycin Clarithromycin The serum concentration of Pravastatin can be increased when it is combined with Clarithromycin.
Felodipine Felodipine Pravastatin may decrease the excretion rate of Felodipine which could result in a higher serum level.
Quinapril Quinapril The excretion of Quinapril can be decreased when combined with Pravastatin.
Simvastatin Simvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Simvastatin.
Teniposide Injection Teniposide Injection Pravastatin may decrease the excretion rate of Teniposide which could result in a higher serum level.
Itraconazole Itraconazole The serum concentration of Pravastatin can be increased when it is combined with Itraconazole.
Bisoprolol Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Pravastatin.
Isradipine Isradipine Pravastatin may decrease the excretion rate of Isradipine which could result in a higher serum level.
Omeprazole Omeprazole Omeprazole may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Fluvastatin Fluvastatin The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Fluvastatin.
Venlafaxine Venlafaxine Venlafaxine may increase the excretion rate of Pravastatin which could result in a lower serum level and potentially a reduction in efficacy.
Nizatidine Nizatidine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Nizatidine.
Stavudine Stavudine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Stavudine.
Fluvoxamine Fluvoxamine Pravastatin may decrease the excretion rate of Fluvoxamine which could result in a higher serum level.
Nefazodone Nefazodone Nefazodone may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Losartan Losartan Pravastatin may decrease the excretion rate of Losartan which could result in a higher serum level.
Valacyclovir Valacyclovir The excretion of Valaciclovir can be decreased when combined with Pravastatin.
Lansoprazole Lansoprazole The excretion of Pravastatin can be decreased when combined with Lansoprazole.
Alprostadil Urogenital Alprostadil Urogenital The excretion of Alprostadil can be decreased when combined with Pravastatin.
Nicardipine Nicardipine Nicardipine may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Saquinavir Saquinavir The serum concentration of Pravastatin can be decreased when it is combined with Saquinavir.
Metformin Metformin Metformin may increase the hypolipidaemic activities of Pravastatin.
Lamivudine Lamivudine Pravastatin may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole Pravastatin may decrease the excretion rate of Riluzole which could result in a higher serum level.
Glimepiride Glimepiride Pravastatin may decrease the excretion rate of Glimepiride which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Pravastatin.
Indinavir Indinavir Indinavir may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Ritonavir Ritonavir Ritonavir may increase the myopathic rhabdomyolysis activities of Pravastatin.
Docetaxel Injection Docetaxel Injection The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Docetaxel.
Cidofovir Injection Cidofovir Injection The excretion of Cidofovir can be decreased when combined with Pravastatin.
Valsartan Valsartan The excretion of Pravastatin can be decreased when combined with Valsartan.
Donepezil Donepezil Pravastatin may decrease the excretion rate of Donepezil which could result in a higher serum level.
Nelfinavir Nelfinavir The serum concentration of Pravastatin can be decreased when it is combined with Nelfinavir.
Fexofenadine Fexofenadine The serum concentration of Fexofenadine can be increased when it is combined with Pravastatin.
Loratadine Loratadine Pravastatin may decrease the excretion rate of Loratadine which could result in a higher serum level.
Carvedilol Carvedilol The serum concentration of Pravastatin can be increased when it is combined with Carvedilol.
Propafenone Propafenone The serum concentration of Pravastatin can be increased when it is combined with Propafenone.
Letrozole Letrozole The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Letrozole.
Raloxifene Raloxifene Pravastatin may decrease the excretion rate of Raloxifene which could result in a higher serum level.
Paroxetine Paroxetine The risk or severity of increased glucose can be increased when Pravastatin is combined with Paroxetine.
Efavirenz Efavirenz The serum concentration of Pravastatin can be decreased when it is combined with Efavirenz.
Sildenafil Sildenafil The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Sildenafil.
Celecoxib Celecoxib Celecoxib may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Rosiglitazone Rosiglitazone Pravastatin may decrease the excretion rate of Rosiglitazone which could result in a higher serum level.
Oseltamivir Oseltamivir The excretion of Oseltamivir can be decreased when combined with Pravastatin.
Colesevelam Colesevelam Colesevelam can cause a decrease in the absorption of Pravastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rabeprazole Rabeprazole Rabeprazole may decrease the excretion rate of Pravastatin which could result in a higher serum level.
Terbinafine Terbinafine The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Pravastatin is combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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