Glimepiride

Generic name: Pronounced as (glye' me pye ride)
Brand names
  • Amaryl®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 05/15/2020

Glimepiride is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Glimepiride lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally. Glimepiride is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated).

Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

Glimepiride comes as a tablet to take by mouth. It is usually taken once a day with breakfast or the first main meal of the day. To help you remember to take glimepiride, take it at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take glimepiride exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of glimepiride and gradually increase your dose if needed. After you have taken glimepiride for some time, glimepiride may not control your blood sugar as well as it did at the beginning of your treatment. Your doctor may adjust the dose of your medication as needed so that the medication will work best for you. Be sure to tell your doctor how you are feeling and if your blood sugar test results have been higher or lower than normal at any time during your treatment.

Glimepiride helps control blood sugar but does not cure diabetes. Continue to take glimepiride even if you feel well. Do not stop taking glimepiride without talking to your doctor.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking glimepiride,

  • tell your doctor and pharmacist if you are allergic to glimepiride, any other medications, or any of the ingredients in glimepiride. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention anticoagulants ('blood thinners') such as warfarin (Coumadin); aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); beta blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal); chloramphenicol; clarithromycin (Biaxin); disopyramide (Norpace); diuretics ('water pills'); fluconazole (Diflucan); fluoxetine (Prozac, Sarafem); hormone replacement therapy and hormonal contraceptives (birth control pills, patches, rings, implants, and injections); insulin or other medications to treat high blood sugar or diabetes; isoniazid (INH); MAO inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); medications for asthma and colds; medications for mental illness and nausea; miconazole (Monistat); niacin; oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); phenytoin (Dilantin); probenecid (Benemid); quinolone and fluoroquinolone antibiotics such as cinoxacin (Cinobac), ciprofloxacin (Cipro), enoxacin (Penetrex), gatifloxacin (Tequin), levofloxacin (Levaquin), lomefloxacin (Maxaquin), moxifloxacin (Avelox), nalidixic acid (NegGram), norfloxacin (Noroxin), ofloxacin (Floxin), sparfloxacin (Zagam), trovafloxacin and alatrofloxacin combination (Trovan); rifampin (Rifadin); salicylate pain relievers such as choline magnesium trisalicylate, choline salicylate (Arthropan), diflunisal (Dolobid), magnesium salicylate (Doan's, others), and salsalate (Argesic, Disalcid, Salgesic); sulfa antibiotics such as co-trimoxazole (Bactrim, Septra); sulfasalazine (Azulfidine); and thyroid medications. Also be sure to tell your doctor or pharmacist if you stop taking any medications while taking glimepiride. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had G6PD deficiency (an inherited condition causing premature destruction of red blood cells or hemolytic anemia); if you have hormone disorders involving the adrenal, pituitary, or thyroid gland; or if you have heart, kidney, or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking glimepiride, call your doctor.

  • talk to your doctor about the risks and benefits of taking glimepiride if you are 65 years of age or older. Older adults should not usually take glimepiride because it is not as safe or effective as other medications that can be used to treat the same condition.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking glimepiride.

  • ask your doctor about the safe use of alcoholic beverages while you are taking glimepiride. Alcohol can make the side effects from glimepiride worse. Consuming alcohol while taking glimepiride also may cause symptoms such as flushing (reddening of the face), headache, nausea, vomiting, chest pain, weakness, blurred vision, mental confusion, sweating, choking, breathing difficulty, and anxiety.

  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Glimepiride may make your skin sensitive to sunlight.

  • ask your doctor what to do if you get sick, develop an infection or fever, experience unusual stress, or are injured. These conditions can affect your blood sugar and the amount of glimepiride you may need.

Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. It is important to eat a healthy diet, exercise regularly, and lose weight if necessary.

Before you start to take glimepiride, ask you doctor what you should do if you forget to take a dose. Write these directions down so that you can refer to them later.

As a general rule, take the missed dose as soon as you remember it. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

This medication may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms.

  • Glimepiride may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • dizziness

    • nausea

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • yellowing of the skin or eyes

    • light-colored stools

    • dark urine

    • pain in the upper right part of the stomach

    • unusual bruising or bleeding

    • diarrhea

    • fever

    • sore throat

  • Glimepiride may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

  • In one study, people who took a medication similar to glimepiride to treat their diabetes were more likely to die of heart problems than people who were treated with insulin and diet changes. Talk to your doctor about the risks of taking glimepiride.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include hypoglycemia symptoms as well as the following:

  • seizures

  • loss of consciousness

Keep all appointments with your doctor and the laboratory. Your fasting blood sugar levels and glycosylated hemoglobin (HbA1c) should be checked regularly to determine your response to glimepiride. Your doctor may order other lab tests to check your response to glimepiride. Your doctor will also tell you how to check your response to this medication by measuring your blood sugar levels at home. Follow these instructions carefully.

You should always wear a diabetic identification bracelet to be sure you get proper treatment in an emergency.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Avandaryl® (containing Glimepiride, Rosiglitazone)
  • Duetact® (containing Glimepiride, Pioglitazone)

Drug Interaction
Moxifloxacin Moxifloxacin The therapeutic efficacy of Glimepiride can be increased when used in combination with Moxifloxacin.
Repaglinide Repaglinide The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Repaglinide.
Montelukast Montelukast The metabolism of Montelukast can be decreased when combined with Glimepiride.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The risk or severity of hypoglycemia can be increased when Insulin glargine is combined with Glimepiride.
Leflunomide Leflunomide The metabolism of Glimepiride can be decreased when combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Glimepiride can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Glimepiride can be decreased when combined with Nevirapine.
Atorvastatin Atorvastatin Glimepiride may decrease the excretion rate of Atorvastatin which could result in a higher serum level.
Candesartan Candesartan The metabolism of Glimepiride can be decreased when combined with Candesartan.
Clopidogrel Clopidogrel The metabolism of Glimepiride can be decreased when combined with Clopidogrel.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole Erythromycin may decrease the excretion rate of Glimepiride which could result in a higher serum level.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The therapeutic efficacy of Glimepiride can be decreased when used in combination with Conjugated estrogens.
Fenofibrate Fenofibrate The risk or severity of hypoglycemia can be increased when Fenofibrate is combined with Glimepiride.
Miglitol Miglitol The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Miglitol.
Olsalazine Olsalazine Olsalazine may increase the hypoglycemic activities of Glimepiride.
Penbutolol Penbutolol Acebutolol may increase the arrhythmogenic activities of Glimepiride.
Prednisone Prednisone The risk or severity of hyperglycemia can be increased when Prednisone is combined with Glimepiride.
Ranitidine Ranitidine The serum concentration of Glimepiride can be increased when it is combined with Ranitidine.
Reserpine Reserpine Reserpine may decrease the excretion rate of Glimepiride which could result in a higher serum level.
Sumatriptan Sumatriptan The therapeutic efficacy of Glimepiride can be increased when used in combination with Sumatriptan.
Tacrolimus Tacrolimus The therapeutic efficacy of Glimepiride can be decreased when used in combination with Tacrolimus.
Triamcinolone Triamcinolone The risk or severity of hyperglycemia can be increased when Triamcinolone is combined with Glimepiride.
Fluconazole Injection Fluconazole Injection The serum concentration of Glimepiride can be increased when it is combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The metabolism of Hydromorphone can be decreased when combined with Glimepiride.
Levofloxacin Injection Levofloxacin Injection The therapeutic efficacy of Glimepiride can be increased when used in combination with Levofloxacin.
Methylprednisolone Injection Methylprednisolone Injection The risk or severity of hyperglycemia can be increased when Methylprednisolone is combined with Glimepiride.
Metronidazole Injection Metronidazole Injection The metabolism of Glimepiride can be decreased when combined with Metronidazole.
Zidovudine Injection Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Glimepiride.
Altretamine Altretamine Amphetamine may increase the hypoglycemic activities of Glimepiride.
Cyclosporine Cyclosporine Cyclosporine may decrease the excretion rate of Glimepiride which could result in a higher serum level.
Ondansetron Ondansetron The metabolism of Ondansetron can be decreased when combined with Glimepiride.
Torsemide Torsemide The therapeutic efficacy of Glimepiride can be increased when used in combination with Torasemide.
Olanzapine Olanzapine The therapeutic efficacy of Glimepiride can be decreased when used in combination with Olanzapine.
Alosetron Alosetron The metabolism of Alosetron can be decreased when combined with Glimepiride.
Dofetilide Dofetilide Dofetilide may increase the arrhythmogenic activities of Glimepiride.
Hydroxychloroquine Hydroxychloroquine The therapeutic efficacy of Glimepiride can be increased when used in combination with Hydroxychloroquine.
Meloxicam Meloxicam The protein binding of Glimepiride can be decreased when combined with Meloxicam.
Telmisartan Telmisartan Glimepiride may decrease the excretion rate of Telmisartan which could result in a higher serum level.
Anakinra Anakinra The metabolism of Glimepiride can be increased when combined with Anakinra.
Linezolid Linezolid Linezolid may increase the hypoglycemic activities of Glimepiride.
Trimipramine Trimipramine The metabolism of Glimepiride can be decreased when combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Glimepiride can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Glimepiride can be decreased when combined with Modafinil.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The protein binding of Glimepiride can be decreased when combined with Choline magnesium trisalicylate.
Sirolimus Sirolimus The therapeutic efficacy of Glimepiride can be decreased when used in combination with Sirolimus.
Epinephrine Injection Epinephrine Injection The therapeutic efficacy of Glimepiride can be decreased when used in combination with Epinephrine.
Escitalopram Escitalopram The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Escitalopram.
Olmesartan Olmesartan Olmesartan may decrease the excretion rate of Glimepiride which could result in a higher serum level.
Zonisamide Zonisamide Zonisamide may increase the arrhythmogenic activities of Glimepiride.
Adalimumab Injection Adalimumab Injection The metabolism of Glimepiride can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The therapeutic efficacy of Glimepiride can be decreased when used in combination with Aripiprazole.
Ezetimibe Ezetimibe Glimepiride may decrease the excretion rate of Ezetimibe which could result in a higher serum level.
Teriparatide Injection Teriparatide Injection The therapeutic efficacy of Glimepiride can be decreased when used in combination with Teriparatide.
Atazanavir Atazanavir The therapeutic efficacy of Glimepiride can be decreased when used in combination with Atazanavir.
Eletriptan Eletriptan The metabolism of Glimepiride can be decreased when combined with Eletriptan.
Rosuvastatin Rosuvastatin The therapeutic efficacy of Glimepiride can be increased when used in combination with Rosuvastatin.
Aprepitant Aprepitant The metabolism of Glimepiride can be decreased when combined with Aprepitant.
Fosamprenavir Fosamprenavir The therapeutic efficacy of Glimepiride can be decreased when used in combination with Fosamprenavir.
Gemifloxacin Gemifloxacin The therapeutic efficacy of Glimepiride can be increased when used in combination with Gemifloxacin.
Progesterone Progesterone The therapeutic efficacy of Glimepiride can be decreased when used in combination with Progesterone.
Infliximab Injection Infliximab Injection The metabolism of Glimepiride can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Glimepiride can be decreased when combined with Oxandrolone.
Protriptyline Protriptyline Protriptyline may decrease the hypoglycemic activities of Glimepiride.
Duloxetine Duloxetine The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Duloxetine.
Norethindrone Norethindrone The therapeutic efficacy of Glimepiride can be decreased when used in combination with Norethisterone.
Tinidazole Tinidazole Glimepiride may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Bosentan Bosentan Bosentan may decrease the excretion rate of Glimepiride which could result in a higher serum level.
Insulin Aspart (rDNA Origin) Injection Insulin Aspart (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Insulin aspart.
Voriconazole Voriconazole The serum concentration of Glimepiride can be increased when it is combined with Voriconazole.
Dextroamphetamine Dextroamphetamine Amphetamine may increase the hypoglycemic activities of Glimepiride.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Glimepiride can be increased when combined with Peginterferon alfa-2b.
Pramlintide Injection Pramlintide Injection The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Pramlintide.
Exenatide Injection Exenatide Injection Exenatide may increase the hypoglycemic activities of Glimepiride.
Isocarboxazid Isocarboxazid Isocarboxazid may increase the hypoglycemic activities of Glimepiride.
Ramelteon Ramelteon The metabolism of Ramelteon can be decreased when combined with Glimepiride.
Pregabalin Pregabalin Glimepiride may increase the arrhythmogenic activities of Pregabalin.
Tipranavir Tipranavir Tipranavir may decrease the excretion rate of Glimepiride which could result in a higher serum level.
Felbamate Felbamate The metabolism of Glimepiride can be decreased when combined with Felbamate.
Insulin Detemir (rDNA Origin) Injection Insulin Detemir (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Insulin detemir.
Ranolazine Ranolazine Glimepiride may decrease the excretion rate of Ranolazine which could result in a higher serum level.
Abatacept Injection Abatacept Injection The metabolism of Glimepiride can be increased when combined with Abatacept.
Rasagiline Rasagiline Rasagiline may increase the hypoglycemic activities of Glimepiride.
Imatinib Imatinib The metabolism of Glimepiride can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin Sitagliptin may increase the hypoglycemic activities of Glimepiride.
Gefitinib Gefitinib The metabolism of Glimepiride can be decreased when combined with Gefitinib.
Paliperidone Paliperidone The therapeutic efficacy of Glimepiride can be decreased when used in combination with Paliperidone.
Bortezomib Bortezomib The metabolism of Glimepiride can be decreased when combined with Bortezomib.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Insulin glulisine.
Bismuth Subsalicylate Bismuth Subsalicylate Bismuth subsalicylate may increase the hypoglycemic activities of Glimepiride.
Darunavir Darunavir The therapeutic efficacy of Glimepiride can be increased when used in combination with Darunavir.
Nabilone Nabilone The metabolism of Glimepiride can be decreased when combined with Nabilone.
Vorinostat Vorinostat The therapeutic efficacy of Glimepiride can be decreased when used in combination with Vorinostat.
Sorafenib Sorafenib The metabolism of Glimepiride can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Sunitinib.
Dronabinol Dronabinol The metabolism of Dronabinol can be decreased when combined with Glimepiride.
Mexiletine Mexiletine Glimepiride may increase the arrhythmogenic activities of Mexiletine.
Armodafinil Armodafinil The metabolism of Glimepiride can be decreased when combined with Armodafinil.
Temsirolimus Temsirolimus The therapeutic efficacy of Glimepiride can be decreased when used in combination with Temsirolimus.
Nilotinib Nilotinib The therapeutic efficacy of Glimepiride can be decreased when used in combination with Nilotinib.
Bexarotene Bexarotene The metabolism of Bexarotene can be decreased when combined with Glimepiride.
Budesonide Budesonide The risk or severity of hyperglycemia can be increased when Glimepiride is combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Glimepiride can be decreased when combined with Chloramphenicol.
Etravirine Etravirine The metabolism of Glimepiride can be decreased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection The therapeutic efficacy of Glimepiride can be decreased when used in combination with Arsenic trioxide.
Desvenlafaxine Desvenlafaxine The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Desvenlafaxine.
Nebivolol Nebivolol Nebivolol may increase the arrhythmogenic activities of Glimepiride.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Glimepiride.
Flecainide Flecainide Flecainide may increase the arrhythmogenic activities of Glimepiride.
Certolizumab Injection Certolizumab Injection The metabolism of Glimepiride can be increased when combined with Certolizumab pegol.
Milnacipran Milnacipran The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Milnacipran.
Betaxolol Betaxolol Betaxolol may increase the arrhythmogenic activities of Glimepiride.
Iloperidone Iloperidone The therapeutic efficacy of Glimepiride can be decreased when used in combination with Iloperidone.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Glimepiride.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Glimepiride.
Everolimus Everolimus The therapeutic efficacy of Glimepiride can be decreased when used in combination with Everolimus.
Dronedarone Dronedarone Glimepiride may increase the arrhythmogenic activities of Dronedarone.
Saxagliptin Saxagliptin Saxagliptin may increase the hypoglycemic activities of Glimepiride.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Glimepiride.
Golimumab Injection Golimumab Injection The metabolism of Glimepiride can be increased when combined with Golimumab.
Asenapine Asenapine The therapeutic efficacy of Glimepiride can be decreased when used in combination with Asenapine.
Pitavastatin Pitavastatin Glimepiride may decrease the excretion rate of Pitavastatin which could result in a higher serum level.
Ulipristal Ulipristal The therapeutic efficacy of Glimepiride can be decreased when used in combination with Ulipristal.
Levonorgestrel Levonorgestrel The therapeutic efficacy of Glimepiride can be decreased when used in combination with Levonorgestrel.
Liraglutide Injection Liraglutide Injection Liraglutide may increase the hypoglycemic activities of Glimepiride.
Tocilizumab Injection Tocilizumab Injection The metabolism of Glimepiride can be increased when combined with Tocilizumab.
Lurasidone Lurasidone The therapeutic efficacy of Glimepiride can be decreased when used in combination with Lurasidone.
Linagliptin Linagliptin Linagliptin may increase the hypoglycemic activities of Glimepiride.
Potassium Iodide Potassium Iodide The therapeutic efficacy of Glimepiride can be decreased when used in combination with Potassium Iodide.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Glimepiride.
Abiraterone Abiraterone The metabolism of Glimepiride can be decreased when combined with Abiraterone.
Triptorelin Injection Triptorelin Injection The therapeutic efficacy of Glimepiride can be decreased when used in combination with Triptorelin.
Ticagrelor Ticagrelor The metabolism of Glimepiride can be decreased when combined with Ticagrelor.
Vemurafenib Vemurafenib The metabolism of Glimepiride can be decreased when combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Glimepiride can be decreased when combined with Vismodegib.
Enzalutamide Enzalutamide The metabolism of Glimepiride can be increased when combined with Enzalutamide.
Regorafenib Regorafenib The metabolism of Glimepiride can be decreased when combined with Regorafenib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The risk or severity of hyperglycemia can be increased when Corticotropin is combined with Glimepiride.
Lorcaserin Lorcaserin The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Mecasermin.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Glimepiride.
Alogliptin Alogliptin Alogliptin may increase the hypoglycemic activities of Glimepiride.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Glimepiride.
Canagliflozin Canagliflozin Canagliflozin may increase the hypoglycemic activities of Glimepiride.
Methazolamide Methazolamide The therapeutic efficacy of Glimepiride can be increased when used in combination with Methazolamide.
Dabrafenib Dabrafenib The metabolism of Glimepiride can be increased when combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Glimepiride.
Levomilnacipran Levomilnacipran The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Levomilnacipran.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Glimepiride.
Ketorolac Injection Ketorolac Injection The protein binding of Glimepiride can be decreased when combined with Ketorolac.
Simeprevir Simeprevir Simeprevir may decrease the excretion rate of Glimepiride which could result in a higher serum level.
Dapagliflozin Dapagliflozin Dapagliflozin may increase the hypoglycemic activities of Glimepiride.
Apremilast Apremilast The metabolism of Glimepiride can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Glimepiride can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Glimepiride can be increased when combined with Siltuximab.
Albiglutide Injection Albiglutide Injection Albiglutide may increase the hypoglycemic activities of Glimepiride.
Testosterone Injection Testosterone Injection Testosterone may increase the hypoglycemic activities of Glimepiride.
Oritavancin Injection Oritavancin Injection The metabolism of Glimepiride can be decreased when combined with Oritavancin.
Empagliflozin Empagliflozin The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Empagliflozin.
Dulaglutide Injection Dulaglutide Injection Dulaglutide may increase the hypoglycemic activities of Glimepiride.
Lanreotide Injection Lanreotide Injection The therapeutic efficacy of Glimepiride can be decreased when used in combination with Lanreotide.
Secukinumab Injection Secukinumab Injection The metabolism of Glimepiride can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The therapeutic efficacy of Glimepiride can be decreased when used in combination with Risperidone.
Insulin Human Inhalation Insulin Human Inhalation The risk or severity of hypoglycemia can be increased when Insulin human is combined with Glimepiride.
Lenvatinib Lenvatinib Lenvatinib may decrease the excretion rate of Glimepiride which could result in a higher serum level.
Haloperidol Injection Haloperidol Injection The therapeutic efficacy of Glimepiride can be decreased when used in combination with Haloperidol.
Deoxycholic Acid Injection Deoxycholic Acid Injection Deoxycholic acid may increase the excretion rate of Glimepiride which could result in a lower serum level and potentially a reduction in efficacy.
Prednisolone Prednisolone The risk or severity of hyperglycemia can be increased when Prednisolone is combined with Glimepiride.
Brexpiprazole Brexpiprazole The therapeutic efficacy of Glimepiride can be decreased when used in combination with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The therapeutic efficacy of Glimepiride can be decreased when used in combination with Ziprasidone.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Insulin degludec.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Glimepiride.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Glimepiride.
Dexamethasone Injection Dexamethasone Injection The risk or severity of hyperglycemia can be increased when Dexamethasone is combined with Glimepiride.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Glimepiride.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Glimepiride.
Furosemide Injection Furosemide Injection The therapeutic efficacy of Glimepiride can be increased when used in combination with Furosemide.
Rucaparib Rucaparib The metabolism of Glimepiride can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection Lixisenatide may increase the hypoglycemic activities of Glimepiride.
Parathyroid Hormone Injection Parathyroid Hormone Injection The therapeutic efficacy of Glimepiride can be decreased when used in combination with Parathyroid hormone.
Doxepin (Insomnia) Doxepin (Insomnia) Glimepiride may decrease the hypoglycemic activities of Doxepin.
Deflazacort Deflazacort The risk or severity of hyperglycemia can be increased when Deflazacort is combined with Glimepiride.
Safinamide Safinamide The metabolism of Glimepiride can be decreased when combined with Safinamide.
Midostaurin Midostaurin The metabolism of Glimepiride can be decreased when combined with Midostaurin.
Abaloparatide Injection Abaloparatide Injection The therapeutic efficacy of Glimepiride can be decreased when used in combination with Abaloparatide.
Enasidenib Enasidenib The metabolism of Glimepiride can be decreased when combined with Enasidenib.
Delafloxacin Delafloxacin The therapeutic efficacy of Glimepiride can be increased when used in combination with Delafloxacin.
Letermovir Letermovir Letermovir may decrease the excretion rate of Glimepiride which could result in a higher serum level.
Semaglutide Injection Semaglutide Injection Semaglutide may increase the hypoglycemic activities of Glimepiride.
Ertugliflozin Ertugliflozin The therapeutic efficacy of Glimepiride can be increased when used in combination with Ertugliflozin.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Glimepiride.
Apalutamide Apalutamide The metabolism of Glimepiride can be increased when combined with Apalutamide.
Avatrombopag Avatrombopag The metabolism of Glimepiride can be increased when combined with Avatrombopag.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Glimepiride.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Glimepiride.
Stiripentol Stiripentol The metabolism of Glimepiride can be decreased when combined with Stiripentol.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection Glimepiride may decrease the excretion rate of Paclitaxel which could result in a higher serum level.
Rifamycin Rifamycin The metabolism of Glimepiride can be decreased when combined with Rifamycin.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Glimepiride can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Glimepiride.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Glimepiride.
Alpelisib Alpelisib The serum concentration of Glimepiride can be decreased when it is combined with Alpelisib.
Triclabendazole Triclabendazole The metabolism of Glimepiride can be decreased when combined with Triclabendazole.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Glimepiride.
Phenytoin Injection Phenytoin Injection The therapeutic efficacy of Phenytoin can be decreased when used in combination with Glimepiride.
Fosphenytoin Injection Fosphenytoin Injection The therapeutic efficacy of Fosphenytoin can be decreased when used in combination with Glimepiride.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Glimepiride.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Glimepiride.
Teprotumumab-trbw Injection Teprotumumab-trbw Injection The therapeutic efficacy of Glimepiride can be decreased when used in combination with Teprotumumab.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Glimepiride.
Octreotide Octreotide The therapeutic efficacy of Glimepiride can be decreased when used in combination with Octreotide.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection Glimepiride may decrease the excretion rate of Belantamab mafodotin which could result in a higher serum level.
Pralsetinib Pralsetinib Pralsetinib may decrease the excretion rate of Glimepiride which could result in a higher serum level.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Glimepiride can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The therapeutic efficacy of Glimepiride can be decreased when used in combination with Drospirenone.
Fenoprofen Fenoprofen The protein binding of Glimepiride can be decreased when combined with Fenoprofen.
Indomethacin Indomethacin The protein binding of Glimepiride can be decreased when combined with Indomethacin.
Mefenamic Acid Mefenamic Acid The protein binding of Glimepiride can be decreased when combined with Mefenamic acid.
Naproxen Naproxen The protein binding of Glimepiride can be decreased when combined with Naproxen.
Tolmetin Tolmetin The protein binding of Glimepiride can be decreased when combined with Tolmetin.
Sulindac Sulindac The protein binding of Glimepiride can be decreased when combined with Sulindac.
Floxuridine Floxuridine The metabolism of Glimepiride can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital The metabolism of Glimepiride can be decreased when combined with Phenobarbital.
Primidone Primidone The metabolism of Primidone can be decreased when combined with Glimepiride.
Methsuximide Methsuximide Methsuximide may increase the arrhythmogenic activities of Glimepiride.
Chlorpromazine Chlorpromazine The therapeutic efficacy of Glimepiride can be decreased when used in combination with Chlorpromazine.
Diazepam Diazepam The metabolism of Diazepam can be decreased when combined with Glimepiride.
Bromocriptine Bromocriptine The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Glimepiride can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine Phenelzine may increase the hypoglycemic activities of Glimepiride.
Procarbazine Procarbazine Procarbazine may increase the hypoglycemic activities of Glimepiride.
Prochlorperazine Prochlorperazine The therapeutic efficacy of Glimepiride can be decreased when used in combination with Prochlorperazine.
Thioridazine Thioridazine The therapeutic efficacy of Glimepiride can be decreased when used in combination with Thioridazine.
Trifluoperazine Trifluoperazine The therapeutic efficacy of Glimepiride can be decreased when used in combination with Trifluoperazine.
Dapsone Dapsone The metabolism of Dapsone can be decreased when combined with Glimepiride.
Sulfadiazine Sulfadiazine The therapeutic efficacy of Glimepiride can be increased when used in combination with Sulfadiazine.
Methadone Methadone The metabolism of Methadone can be decreased when combined with Glimepiride.
Ibuprofen Ibuprofen The protein binding of Glimepiride can be decreased when combined with Ibuprofen.
Perphenazine Perphenazine The therapeutic efficacy of Glimepiride can be decreased when used in combination with Perphenazine.
Fluphenazine Fluphenazine The therapeutic efficacy of Glimepiride can be decreased when used in combination with Fluphenazine.
Phentermine Phentermine The therapeutic efficacy of Glimepiride can be increased when used in combination with Phentermine.
Amoxapine Amoxapine Amoxapine may decrease the hypoglycemic activities of Glimepiride.
Sulfasalazine Sulfasalazine Sulfasalazine may increase the hypoglycemic activities of Glimepiride.
Hydrocortisone Hydrocortisone The risk or severity of hyperglycemia can be increased when Hydrocortisone is combined with Glimepiride.
Doxorubicin Doxorubicin Glimepiride may decrease the excretion rate of Doxorubicin which could result in a higher serum level.
Cimetidine Cimetidine The serum concentration of Glimepiride can be increased when it is combined with Cimetidine.
Warfarin Warfarin The therapeutic efficacy of Warfarin can be increased when used in combination with Glimepiride.
Loperamide Loperamide Loperamide may increase the arrhythmogenic activities of Glimepiride.
Promethazine Promethazine The therapeutic efficacy of Glimepiride can be decreased when used in combination with Promethazine.
Meclofenamate Meclofenamate The protein binding of Glimepiride can be decreased when combined with Meclofenamic acid.
Daunorubicin Daunorubicin Glimepiride may decrease the excretion rate of Daunorubicin which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Glimepiride may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Digoxin Digoxin Glimepiride may increase the arrhythmogenic activities of Digoxin.
Quinine Quinine The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Quinine.
Ethosuximide Ethosuximide Ethosuximide may increase the arrhythmogenic activities of Glimepiride.
Sulfinpyrazone Sulfinpyrazone The metabolism of Glimepiride can be decreased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Glimepiride can be decreased when used in combination with Chlorothiazide.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Glimepiride can be decreased when used in combination with Chlorthalidone.
Metolazone Metolazone The therapeutic efficacy of Glimepiride can be decreased when used in combination with Metolazone.
Isosorbide Isosorbide The therapeutic efficacy of Glimepiride can be decreased when used in combination with Isosorbide.
Desipramine Desipramine Desipramine may decrease the hypoglycemic activities of Glimepiride.
Amitriptyline Amitriptyline Amitriptyline may decrease the hypoglycemic activities of Glimepiride.
Imipramine Imipramine Imipramine may decrease the hypoglycemic activities of Glimepiride.
Probenecid Probenecid The protein binding of Glimepiride can be decreased when combined with Probenecid.
Quinidine Quinidine Glimepiride may increase the arrhythmogenic activities of Quinidine.
Procainamide Procainamide Glimepiride may increase the arrhythmogenic activities of Procainamide.
Isoniazid Isoniazid The metabolism of Glimepiride can be decreased when combined with Isoniazid.
Rifampin Rifampin The serum concentration of Glimepiride can be decreased when it is combined with Rifampicin.
Disopyramide Disopyramide Glimepiride may increase the arrhythmogenic activities of Disopyramide.
Valproic Acid Valproic Acid The metabolism of Glimepiride can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Glimepiride can be decreased when combined with Tamoxifen.
Levothyroxine Levothyroxine The therapeutic efficacy of Glimepiride can be decreased when used in combination with Levothyroxine.
Liothyronine Liothyronine The therapeutic efficacy of Glimepiride can be decreased when used in combination with Liothyronine.
Methimazole Methimazole The therapeutic efficacy of Glimepiride can be decreased when used in combination with Methimazole.
Propylthiouracil Propylthiouracil The therapeutic efficacy of Glimepiride can be decreased when used in combination with Propylthiouracil.
Chlorpropamide Chlorpropamide The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Chlorpropamide.
Tolbutamide Tolbutamide The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Tolbutamide.
Tolazamide Tolazamide The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Tolazamide.
Dextromethorphan Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Glimepiride.
Niacin Niacin The therapeutic efficacy of Glimepiride can be decreased when used in combination with Niacin.
Baclofen Baclofen The therapeutic efficacy of Glimepiride can be decreased when used in combination with Baclofen.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Glimepiride can be decreased when used in combination with Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Glimepiride can be decreased when used in combination with Hydrochlorothiazide.
Danazol Danazol The therapeutic efficacy of Glimepiride can be decreased when used in combination with Danazol.
Disulfiram Disulfiram Glimepiride may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Propranolol may increase the arrhythmogenic activities of Glimepiride.
Pseudoephedrine Pseudoephedrine The therapeutic efficacy of Glimepiride can be decreased when used in combination with Pseudoephedrine.
Nortriptyline Nortriptyline Nortriptyline may decrease the hypoglycemic activities of Glimepiride.
Spironolactone Spironolactone Glimepiride may decrease the excretion rate of Spironolactone which could result in a higher serum level.
Nadolol Nadolol Nadolol may increase the arrhythmogenic activities of Glimepiride.
Fluoxymesterone Fluoxymesterone Fluoxymesterone may increase the hypoglycemic activities of Glimepiride.
Fluorouracil Injection Fluorouracil Injection The metabolism of Glimepiride can be decreased when combined with Fluorouracil.
Cefaclor Cefaclor Glimepiride may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Acetazolamide Acetazolamide The therapeutic efficacy of Glimepiride can be increased when used in combination with Acetazolamide.
Calcitonin Salmon Injection Calcitonin Salmon Injection The therapeutic efficacy of Glimepiride can be decreased when used in combination with Salmon calcitonin.
Ketoconazole Ketoconazole Ketoconazole may decrease the excretion rate of Glimepiride which could result in a higher serum level.
Vincristine Injection Vincristine Injection Glimepiride may decrease the excretion rate of Vincristine which could result in a higher serum level.
Dipyridamole Dipyridamole Glimepiride may decrease the excretion rate of Dipyridamole which could result in a higher serum level.
Vinblastine Vinblastine Vinblastine may decrease the excretion rate of Glimepiride which could result in a higher serum level.
Ethacrynic Acid Ethacrynic Acid The therapeutic efficacy of Glimepiride can be decreased when used in combination with Etacrynic acid.
Metoprolol Metoprolol Metoprolol may increase the arrhythmogenic activities of Glimepiride.
Aspirin Aspirin The risk or severity of hypoglycemia can be increased when Acetylsalicylic acid is combined with Glimepiride.
Salsalate Salsalate The protein binding of Glimepiride can be decreased when combined with Salsalate.
Hyoscyamine Hyoscyamine Glimepiride may increase the arrhythmogenic activities of Hyoscyamine.
Trimethoprim Trimethoprim The metabolism of Trimethoprim can be decreased when combined with Glimepiride.
Diltiazem Diltiazem Glimepiride may increase the arrhythmogenic activities of Diltiazem.
Nifedipine Nifedipine Nifedipine may increase the arrhythmogenic activities of Glimepiride.
Timolol Timolol Timolol may increase the arrhythmogenic activities of Glimepiride.
Verapamil Verapamil Verapamil may increase the arrhythmogenic activities of Glimepiride.
Atenolol Atenolol Atenolol may increase the arrhythmogenic activities of Glimepiride.
Pindolol Pindolol The therapeutic efficacy of Glimepiride can be increased when used in combination with Pindolol.
Cisplatin Injection Cisplatin Injection The metabolism of Glimepiride can be decreased when combined with Cisplatin.
Diflunisal Diflunisal Diflunisal may increase the hypoglycemic activities of Glimepiride.
Piroxicam Piroxicam The protein binding of Glimepiride can be decreased when combined with Piroxicam.
Bumetanide Bumetanide The therapeutic efficacy of Glimepiride can be increased when used in combination with Bumetanide.
Glyburide Glyburide Glyburide may decrease the excretion rate of Glimepiride which could result in a higher serum level.
Glipizide Glipizide The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Glipizide.
Indapamide Indapamide The therapeutic efficacy of Glimepiride can be decreased when used in combination with Indapamide.
Pentamidine Injection Pentamidine Injection The therapeutic efficacy of Glimepiride can be decreased when used in combination with Pentamidine.
Labetalol Labetalol The therapeutic efficacy of Glimepiride can be increased when used in combination with Labetalol.
Leuprolide Injection Leuprolide Injection The therapeutic efficacy of Glimepiride can be decreased when used in combination with Leuprolide.
Gemfibrozil Gemfibrozil The metabolism of Glimepiride can be decreased when combined with Gemfibrozil.
Ketoprofen Ketoprofen The protein binding of Glimepiride can be decreased when combined with Ketoprofen.
Flurbiprofen Flurbiprofen The protein binding of Glimepiride can be decreased when combined with Flurbiprofen.
Amiodarone Amiodarone The risk or severity of adverse effects can be increased when Glimepiride is combined with Amiodarone.
Lovastatin Lovastatin The metabolism of Glimepiride can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The therapeutic efficacy of Glimepiride can be increased when used in combination with Ciprofloxacin.
Mesalamine Mesalamine Mesalazine may increase the hypoglycemic activities of Glimepiride.
Diclofenac Diclofenac The protein binding of Glimepiride can be decreased when combined with Diclofenac.
Fluoxetine Fluoxetine The metabolism of Glimepiride can be decreased when combined with Fluoxetine.
Nimodipine Nimodipine Nimodipine may increase the arrhythmogenic activities of Glimepiride.
Clozapine Clozapine The therapeutic efficacy of Glimepiride can be decreased when used in combination with Clozapine.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Glimepiride.
Ofloxacin Ofloxacin The therapeutic efficacy of Glimepiride can be increased when used in combination with Ofloxacin.
Clarithromycin Clarithromycin The serum concentration of Glimepiride can be increased when it is combined with Clarithromycin.
Benazepril Benazepril The risk or severity of hypoglycemia can be increased when Benazepril is combined with Glimepiride.
Etodolac Etodolac The protein binding of Glimepiride can be decreased when combined with Etodolac.
Felodipine Felodipine Felodipine may increase the arrhythmogenic activities of Glimepiride.
Nabumetone Nabumetone The protein binding of Glimepiride can be decreased when combined with Nabumetone.
Pravastatin Pravastatin Pravastatin may decrease the excretion rate of Glimepiride which could result in a higher serum level.
Simvastatin Simvastatin The metabolism of Glimepiride can be decreased when combined with Simvastatin.
Amlodipine Amlodipine Amlodipine may increase the arrhythmogenic activities of Glimepiride.
Teniposide Injection Teniposide Injection The metabolism of Glimepiride can be decreased when combined with Teniposide.
Oxaprozin Oxaprozin The protein binding of Glimepiride can be decreased when combined with Oxaprozin.
Atovaquone Atovaquone The metabolism of Glimepiride can be decreased when combined with Atovaquone.
Sotalol Sotalol The risk or severity of hypoglycemia can be increased when Sotalol is combined with Glimepiride.
Bisoprolol Bisoprolol The therapeutic efficacy of Glimepiride can be increased when used in combination with Bisoprolol.
Zolpidem Zolpidem The metabolism of Zolpidem can be decreased when combined with Glimepiride.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Glimepiride.
Isradipine Isradipine Glimepiride may increase the arrhythmogenic activities of Isradipine.
Omeprazole Omeprazole The metabolism of Omeprazole can be decreased when combined with Glimepiride.
Cisapride Cisapride The metabolism of Glimepiride can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Glimepiride can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Venlafaxine.
Fluvoxamine Fluvoxamine The metabolism of Glimepiride can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone Glimepiride may decrease the excretion rate of Nefazodone which could result in a higher serum level.
Lamotrigine Lamotrigine Lamotrigine may increase the arrhythmogenic activities of Glimepiride.
Losartan Losartan Glimepiride may increase the arrhythmogenic activities of Losartan.
Lansoprazole Lansoprazole The metabolism of Glimepiride can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Glimepiride.
Nicardipine Nicardipine Nicardipine may increase the arrhythmogenic activities of Glimepiride.
Bupropion Bupropion The metabolism of Bupropion can be decreased when combined with Glimepiride.
Ticlopidine Ticlopidine The metabolism of Glimepiride can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The therapeutic efficacy of Glimepiride can be decreased when used in combination with Saquinavir.
Metformin Metformin The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Metformin.
Nisoldipine Nisoldipine Nisoldipine may increase the arrhythmogenic activities of Glimepiride.
Acarbose Acarbose The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Acarbose.
Indinavir Indinavir The therapeutic efficacy of Glimepiride can be decreased when used in combination with Indinavir.
Ritonavir Ritonavir The therapeutic efficacy of Glimepiride can be decreased when used in combination with Ritonavir.
Clomipramine Clomipramine Clomipramine may decrease the hypoglycemic activities of Glimepiride.
Zafirlukast Zafirlukast The metabolism of Glimepiride can be decreased when combined with Zafirlukast.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Glimepiride.
Valsartan Valsartan The metabolism of Glimepiride can be decreased when combined with Valsartan.
Insulin Lispro Injection Insulin Lispro Injection The risk or severity of hypoglycemia can be increased when Insulin lispro is combined with Glimepiride.
Donepezil Donepezil The metabolism of Donepezil can be decreased when combined with Glimepiride.
Nelfinavir Nelfinavir The therapeutic efficacy of Glimepiride can be decreased when used in combination with Nelfinavir.
Loratadine Loratadine Glimepiride may decrease the excretion rate of Loratadine which could result in a higher serum level.
Carvedilol Carvedilol Carvedilol may increase the arrhythmogenic activities of Glimepiride.
Nilutamide Nilutamide The metabolism of Glimepiride can be decreased when combined with Nilutamide.
Selegiline Selegiline Selegiline may increase the hypoglycemic activities of Glimepiride.
Bicalutamide Bicalutamide The metabolism of Glimepiride can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Glimepiride can be decreased when combined with Sertraline.
Propafenone Propafenone Propafenone may increase the arrhythmogenic activities of Glimepiride.
Irbesartan Irbesartan The metabolism of Irbesartan can be decreased when combined with Glimepiride.
Tamsulosin Tamsulosin The therapeutic efficacy of Glimepiride can be increased when used in combination with Tamsulosin.
Quetiapine Quetiapine The therapeutic efficacy of Glimepiride can be decreased when used in combination with Quetiapine.
Paroxetine Paroxetine The metabolism of Glimepiride can be decreased when combined with Paroxetine.
Tolcapone Tolcapone The metabolism of Glimepiride can be decreased when combined with Tolcapone.
Citalopram Citalopram The risk or severity of hypoglycemia can be increased when Citalopram is combined with Glimepiride.
Capecitabine Capecitabine The metabolism of Glimepiride can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Glimepiride can be decreased when combined with Efavirenz.
Sildenafil Sildenafil The metabolism of Glimepiride can be decreased when combined with Sildenafil.
Celecoxib Celecoxib The therapeutic efficacy of Glimepiride can be increased when used in combination with Celecoxib.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Glimepiride.
Thalidomide Thalidomide The metabolism of Thalidomide can be decreased when combined with Glimepiride.
Colesevelam Colesevelam Colesevelam can cause a decrease in the absorption of Glimepiride resulting in a reduced serum concentration and potentially a decrease in efficacy.
Balsalazide Balsalazide Balsalazide may increase the hypoglycemic activities of Glimepiride.
Nateglinide Nateglinide The risk or severity of hypoglycemia can be increased when Glimepiride is combined with Nateglinide.
Rabeprazole Rabeprazole The metabolism of Glimepiride can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Terbinafine can be decreased when combined with Glimepiride.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists