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Glimepiride

Glimepiride is an oral sulfonylurea medication used alongside diet and exercise to help control blood sugar in adults with type 2 diabetes.

Brand name Amaryl
Drug class Sulfonylurea Compounds
Rx Form 1
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 79 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 7, 2026 🚨Recall on record · 2
Glimepiride at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Glimepiride (Amaryl) is a sulfonylurea that lowers blood sugar in adults with type 2 diabetes, alongside diet and exercise, by prompting the pancreas to release more insulin. It is a familiar, low-cost add-on, usually to metformin, on the market since about 1995 and available as a generic. Most people tolerate it well, and what they tend to notice is modest weight gain or an occasional dip in blood sugar. That dip, called hypoglycemia, is the one thing to watch for, with shakiness, sweating, confusion or a racing heart, and it is likeliest after a skipped meal, alcohol or unusual exercise.

Clinical pearls

  • Take it with breakfast or your first main meal of the day, because skipping that meal raises the risk of low blood sugar.
  • Avoid oral miconazole, an antifungal, because the combination can cause severe low blood sugar.
  • Beta-blockers can hide the racing heart of a low, so rely on sweating, shakiness and confusion as your clues instead.
  • Older adults and people with kidney disease are more prone to lows, so expect a low starting dose and slow increases.
How we write & review this content — our editorial policy →
How you get itPrescription only
Comes asTablet
Earliest FDA record1995
Companies listing it with the FDA27
FDA label last updatedJan 25, 2018
FDA’s strongest warning (boxed)None on the label

Patient information guide A plain-language walkthrough of Glimepiride, written from its FDA label.

What Glimepiride is used for

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Glimepiride tablets are used to help control blood sugar in adults with type 2 diabetes. Here is what the FDA-approved product evidence supports:

  • Improving blood sugar (glycemic) control in adults with type 2 diabetes, always used together with diet and exercise
  • Not approved for type 1 diabetes — it would not be effective
  • Not approved for diabetic ketoacidosis (a serious emergency condition)

How Glimepiride works

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Glimepiride is a sulfonylurea. It works by binding to a specific receptor on the insulin-producing beta cells in your pancreas. This binding closes a channel in the cell membrane (called the ATP-sensitive potassium channel), which triggers the cell to release insulin into your bloodstream. That extra insulin helps your body move glucose (sugar) out of the blood and into your cells, lowering your blood sugar level.

Glimepiride dosage

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Glimepiride comes as a tablet taken once daily by mouth. It should always be taken with breakfast or the first main meal of the day to reduce the risk of low blood sugar. Your prescriber will start you on a low dose and increase it gradually — no more often than every one to two weeks — based on your blood sugar readings.

  • Take once daily with your first meal
  • Do not skip meals after taking your dose
  • If you take colesevelam (a cholesterol medicine), take glimepiride at least 4 hours before it
  • Follow your prescriber's dosing plan exactly — never adjust your dose on your own

Dosing details from the FDA-approved label

From the Glimepiride prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Recommended dosing (general)
    • Starting dose 1 mg or 2 mg once daily, administered with breakfast or the first main meal of the day
    • After reaching a daily dose of 2 mg, increase in increments of 1 mg or 2 mg based upon glycemic response
    • Uptitration should not occur more frequently than every 1 to 2 weeks
    • Maximum: 8 mg once daily
    • Administer with breakfast or the first main meal of the day
  • Patients at increased risk for hypoglycemia (e.g., the elderly or patients with renal impairment)
    • Start on 1 mg once daily
    • A conservative titration scheme is recommended
    • Maximum: 8 mg once daily
    • Elderly or renal impairment: start at 1 mg and titrate slowly
  • Patients transferred from longer half-life sulfonylureas (e.g., chlorpropamide)
    • May have overlapping drug effect for 1 to 2 weeks and should be appropriately monitored for hypoglycemia
    • Monitor for hypoglycemia
  • Coadministration with colesevelam
    • Administer glimepiride tablets at least 4 hours prior to colesevelam
    • Colesevelam reduces glimepiride maximum plasma concentration and total exposure
Read the label’s full dosing text

2 DOSAGE & ADMINISTRATION • Recommended starting dose is 1 or 2 mg once daily. Increase in 1 or 2 mg increments no more frequently than every 1-2 weeks based on glycemic response. Maximum recommended dose is 8 mg once daily. ( 2.1 ) • Administer with breakfast or first meal of the day. ( 2.1 ) • Use 1 mg starting dose and titrate slowly in patients at increased risk for hypoglycemia (e.g., elderly, patients with renal impairment). ( 2.1 ) 2.1 Recommended Dosing • Glimepiride tablets should be administered with breakfast or the first main meal of the day. • The recommended starting dose of glimepiride tablets is 1 mg or 2 mg once daily. Patients at increased risk for hypoglycemia (e.g., the elderly or patients with renal impairment) should be started on 1 mg once daily [ see Warnings and Precautions ( 5.1 ) and Use in Specific Populations ( 8.5 , 8.6 ) ]. After reaching a daily dose of 2 mg, further dose increases can be made in increments of 1 mg or 2 mg based upon the patient's glycemic response. Uptitration should not occur more frequently than every 1 to 2 weeks. A conservative titration scheme is recommended for patients at increased risk for hypoglycemia [ see Warnings and Precautions ( 5.1 ) and Use in Specific Populations ( 8.5 , 8.6 ) ]. • The maximum recommended dose is 8 mg once daily. • Patients being transferred to glimepiride tablets from longer half-life sulfonylureas (e.g., chlorpropamide) may have overlapping drug effect for 1 to 2 weeks and should be appropriately monitored for hypoglycemia. • When colesevelam is coadministered with glimepiride, maximum plasma concentration and total exposure to glimepiride is reduced. Therefore, glimepiride tablets should be administered at least 4 hours prior to colesevelam.

Read the full Dosage and Administration section on DailyMed →

Glimepiride side effects

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The most common side effects reported in clinical trials include:

Common side effects

  • Low blood sugar (hypoglycemia) — the most common side effect
  • Headache
  • Dizziness
  • Nausea
  • Unintentional weight gain
  • Weakness or fatigue
  • Skin rash, itching, or redness (less common)
  • Elevated liver enzyme levels (seen on blood tests in a small number of patients)

When to get medical help

  • Get emergency help right away if you have severe low blood sugar — signs include confusion, seizures, loss of consciousness, or inability to swallow
  • Call your doctor immediately if you have signs of a serious allergic reaction: trouble breathing, swelling of the face or throat, severe skin blistering or peeling
  • Call your doctor if you notice yellowing of the skin or eyes, dark urine, or severe stomach pain — these may signal liver problems
  • Call your doctor if you develop unusual bruising, bleeding, or signs of infection — these could indicate blood cell problems
  • Tell your doctor right away if you are pregnant or planning to become pregnant — glimepiride must be stopped at least two weeks before your due date

Glimepiride warnings and precautions

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  • Low blood sugar (hypoglycemia): This is the most important risk. It can be severe, cause seizures or loss of consciousness, and may impair driving. Risk is highest in older adults, people with kidney disease, those who skip meals, exercise heavily, or drink alcohol. Some people — especially those on beta-blockers — may not feel the usual warning signs.
  • Serious allergic reactions: Rare but potentially life-threatening reactions including anaphylaxis, angioedema (severe swelling), and Stevens-Johnson Syndrome (a severe skin condition) have been reported. Stop glimepiride and seek emergency care if these occur.
  • Hemolytic anemia: In people with G6PD deficiency (a genetic enzyme disorder), glimepiride can break down red blood cells. Cases have also been reported in people without known G6PD deficiency.
  • Possible cardiovascular risk: Older studies on sulfonylurea-class drugs raised concerns about increased cardiovascular mortality compared to diet alone. Your doctor has considered this when prescribing glimepiride for you.
  • No proven cardiovascular benefit: Glimepiride has not been shown in clinical studies to reduce the risk of heart attack, stroke, or other cardiovascular events.

Glimepiride interactions

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Glimepiride can be affected by many common medications and substances. Here are the key ones to know about:

  • Oral miconazole (antifungal): Can cause severe low blood sugar — this combination should be avoided
  • Other diabetes medications and insulin: Increase the blood-sugar-lowering effect, raising hypoglycemia risk
  • Fluconazole (antifungal): Slows the breakdown of glimepiride in the body, raising its levels and increasing low blood sugar risk
  • Rifampin (antibiotic): Speeds up glimepiride breakdown, reducing its effectiveness and potentially worsening blood sugar control
  • Corticosteroids, diuretics, thyroid hormones, and some other medications: Can weaken glimepiride's effect, leading to higher blood sugar
  • Beta-blockers, clonidine, guanethidine, reserpine: Can mask the physical warning signs of low blood sugar (like a fast heartbeat)
  • Alcohol: Can unpredictably raise or lower blood sugar — use with caution
  • Colesevelam (cholesterol medicine): Reduces glimepiride absorption — always take glimepiride at least 4 hours before colesevelam

Interactions listed in the FDA-approved label

From the Glimepiride prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Drugs that may increase the glucose-lowering effect (e.g., oral anti-diabetic medications, insulin, pramlintide acetate, ACE inhibitors, H2 receptor antagonists, fibrates, fluconazole, clarithromycin, quinolones, tetracyclines, NSAIDs, salicylates, sulfonamides, fluoxetine, coumarins, MAO inhibitors): May increase the glucose-lowering effect of glimepiride, increasing susceptibility to and/or intensity of hypoglycemia. When administered, monitor closely for hypoglycemia; when withdrawn, monitor closely for worsening glycemic control.
  • Drugs that may reduce the glucose-lowering effect (e.g., danazol, glucagon, somatropin, protease inhibitors, olanzapine, clozapine, barbiturates, diazoxide, laxatives, rifampin, thiazides and other diuretics, corticosteroids, phenothiazines, thyroid hormones, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, isoniazid): May reduce the glucose-lowering effect of glimepiride, leading to worsening glycemic control. When administered, monitor closely for worsening glycemic control; when withdrawn, monitor closely for hypoglycemia.
  • Beta-blockers, clonidine, and reserpine: May lead to either potentiation or weakening of glimepiride's glucose-lowering effect.
  • Alcohol: Both acute and chronic alcohol intake may potentiate or weaken the glucose-lowering action of glimepiride in an unpredictable fashion.
  • Sympatholytic drugs (beta-blockers, clonidine, guanethidine, reserpine): The signs of hypoglycemia may be reduced or absent.
  • Oral miconazole: A potential interaction with sulfonylureas leading to severe hypoglycemia has been reported; whether it occurs with other miconazole dosage forms is not known.
  • Fluconazole (cytochrome P450 2C9 inhibitor): May inhibit the metabolism of glimepiride, causing increased plasma concentrations which may lead to hypoglycemia.
  • Rifampin (cytochrome P450 2C9 inducer): May induce the metabolism of glimepiride, causing decreased plasma concentrations which may lead to worsening glycemic control.
  • Colesevelam: Can reduce the maximum plasma concentration and total exposure of glimepiride when coadministered; absorption is not reduced when glimepiride is given 4 hours prior. Administer glimepiride at least 4 hours prior to colesevelam.
Read the label’s full interactions text

7 DRUG INTERACTIONS • Certain medications may affect glucose metabolism, requiring glimepiride tablets dose adjustment and close monitoring of blood glucose. ( 7.1 ) • Miconazole: Severe hypoglycemia can occur when glimepiride tablets and oral miconazole are used concomitantly. ( 7.2 ) • Cytochrome P450 2C9 interactions: Inhibitors and inducers of cytochrome P450 2C9 may affect glycemic control by altering glimepiride plasma concentrations. ( 7.3 ) • Colesevelam: Coadministration may reduce glimepiride absorption. Glimepiride tablets should be administered at least 4 hours prior to colesevelam. ( 2.1 , 7.4 ) 7.1 Drugs Affecting Glucose Metabolism A number of medications affect glucose metabolism and may require glimepiride dose adjustment and particularly close monitoring for hypoglycemia or worsening glycemic control. The following are examples of medications that may increase the glucose-lowering effect of sulfonylureas including glimepiride, increasing the susceptibility to and/or intensity of hypoglycemia: oral anti-diabetic medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H 2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly protein-bound, such as fluoxetine, nonsteroidal anti-inflammatory drugs, salicylates, sulfonamides, chloramphenicol, coumarins, probenecid and monoamine oxidase inhibitors. When these medications are administered to a patient receiving glimepiride , monitor the patient closely for hypoglycemia. When these medications are withdrawn from a patient receiving glimepiride , monitor the patient closely for worsening glycemic control.

Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿306 supplements and herbs with documented Glimepiride interactions, ranked by severity Check Glimepiride against a supplement or herb →

Before taking Glimepiride

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  • Do not take glimepiride if you have ever had an allergic reaction to glimepiride itself, any of its ingredients, or to sulfonamide-type drugs
  • Tell your doctor if you have kidney disease — your starting dose will be lower and increases will be made more slowly
  • Tell your doctor if you have liver disease — it is not fully known how liver impairment affects glimepiride, so extra caution is needed
  • Older adults (65+) are at higher risk for low blood sugar and may need a more conservative dosing approach
  • Glimepiride is not recommended for children or teenagers due to effects on body weight and hypoglycemia risk
  • If you are pregnant or planning to become pregnant, talk to your doctor right away — glimepiride must be stopped at least two weeks before your expected delivery date to protect the newborn from severe low blood sugar
  • If you are breastfeeding, monitor your baby closely for signs of low blood sugar (jitteriness, poor feeding, excessive sleepiness) and discuss the risks and benefits with your doctor
  • Tell your doctor if you have G6PD deficiency — a non-sulfonylurea alternative may be safer for you

Glimepiride overdose

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Taking too much glimepiride can cause severe low blood sugar (hypoglycemia). Mild low blood sugar can often be treated by eating or drinking something sugary. Severe cases — especially if the person is confused, having a seizure, or unconscious — are a medical emergency and require immediate treatment with glucagon or intravenous glucose in a hospital setting.

Even after recovery, blood sugar can drop again, so continued monitoring and additional carbohydrate intake may be necessary. If you suspect an overdose, call emergency services right away.

What Glimepiride does in the body

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Glimepiride starts lowering blood sugar after you take it, with its strongest effect occurring roughly 2 to 3 hours after a dose in healthy individuals. It helps lower HbA1c (your average blood sugar over about 3 months), fasting blood sugar, and blood sugar after meals. Like all sulfonylureas, it can also cause modest weight gain over time.

How your body processes Glimepiride

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After taking glimepiride by mouth, blood levels peak in about 2 to 3 hours. Food slightly reduces the peak level but does not meaningfully change overall exposure. The drug is almost entirely bound to proteins in the blood (more than 99.5%) and is completely broken down by the liver — primarily through an enzyme called CYP2C9 — into metabolites that are then cleared mainly through the urine and, to a lesser extent, the stool.

In people with severe kidney disease, breakdown products of glimepiride can build up to much higher levels, increasing the risk of low blood sugar — which is why a lower starting dose is used in those patients. Glimepiride does not meaningfully accumulate in the body with regular daily dosing.

How to store Glimepiride

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Store at 25°C (77°F); excursions permitted to 20°C-25°C (68°F-77°F) . Dispense in well-closed containers with child-resistant closures.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

306

Supplements & herbs that interact with Glimepiride

306 supplements and herbal products have documented interactions with Glimepiride in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 2
  • Moderate · 256
  • Minor · 48
ACTIVATED CHARCOAL Major SIBERIAN COCKLEBUR Major ACAI Moderate ADRAFINIL Moderate AFRICAN WILD POTATO Moderate AGARICUS MUSHROOM Moderate AGMATINE Moderate AGRIMONY Moderate +298 more
Every supplement checked against Glimepiride — ranked by severity The full interaction hub: 2 major · 256 moderate · 48 minor · every one linked to its full report. Check Glimepiride against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

1

Nutrient depletion considerations

Glimepiride has been associated with lower levels of 1 nutrient in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

COENZYME Q10 Insignificant Depletion
See the full Glimepiride nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

Glimepiride: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Glimepiride — the kind of thing our pharmacy team would talk through with you at the counter.

What exactly is glimepiride supposed to do for me?

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Glimepiride helps lower your blood sugar if you have type 2 diabetes. It works by prompting your pancreas to release more insulin, which helps move sugar out of your bloodstream and into your body's cells. It's meant to be used alongside a healthy diet and exercise — not instead of them. Think of it as one important piece of your overall diabetes management plan.

When should I take it, and does it matter if I take it with food?

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Yes, timing with food really matters here. You should take glimepiride with your breakfast or your first main meal of the day — every day. Taking it with a meal helps reduce the risk of your blood sugar dropping too low. Try to make it part of your morning routine so you don't forget.

What does low blood sugar feel like, and what do I do if it happens?

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Low blood sugar (hypoglycemia) is the most common side effect with glimepiride. You might feel shaky, sweaty, dizzy, confused, or notice a racing heart. If you catch it early, eating or drinking something sugary — like juice, glucose tablets, or a few pieces of candy — usually helps quickly. If someone loses consciousness or has a seizure, that's a medical emergency — call 911 right away. It's a good idea to always carry a fast-acting sugar source with you.

Are there any medications or foods I need to be careful about while taking this?

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Quite a few things can interact with glimepiride. Alcohol is a big one — it can unpredictably raise or lower your blood sugar, so use it cautiously. Oral miconazole, a common antifungal, can cause dangerously low blood sugar when combined with glimepiride. Many other medications — from certain antibiotics to blood pressure drugs — can either strengthen or weaken glimepiride's effect. Always tell any doctor or pharmacist you see that you're taking glimepiride before starting any new medication.

I'm pregnant — can I keep taking glimepiride?

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This is really important to discuss with your doctor right away. Glimepiride can cross the placenta and cause low blood sugar in the newborn, sometimes severely. Because of this, glimepiride needs to be stopped at least two weeks before your expected delivery date. If you're breastfeeding, your baby should be monitored closely for signs of low blood sugar. Your doctor can help you find the safest option for managing your blood sugar during pregnancy.

Can my child take glimepiride?

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Glimepiride is not recommended for children or teenagers. Studies in young patients showed that it caused more weight gain and a higher risk of low blood sugar compared to other options like metformin. If your child has type 2 diabetes, their doctor will recommend a treatment that's better suited for them.

Is Glimepiride available over the counter?

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No. Glimepiride is a prescription medicine: every Glimepiride product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Glimepiride first available?

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The earliest FDA record we hold for Glimepiride is from 1995: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Glimepiride was first used.

Who makes Glimepiride?

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27 companies currently list Glimepiride products in the FDA's NDC Directory, including A-S Medication Solutions, Bryant Ranch Prepack, PD-Rx Pharmaceuticals, Inc.. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Glimepiride on HelloPharmacist

📊Glimepiride supplement interactions306 checked — ranked by severity 🌿Drug & Supplement CheckerGlimepiride vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Glimepiride NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Glimepiride Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Glimepiride forms and strengths (how it comes)

Glimepiride is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Glimepiride inactive ingredients by manufacturer.

Tablet

By mouth
Brands Amaryl
How this form is used
What it may be used for
  • Used to improve blood sugar control in adults with type 2 diabetes, alongside diet and exercise
  • Not for treating type 1 diabetes or diabetic ketoacidosis
Important instructions
  • Take once daily by mouth with breakfast or your first main meal of the day
  • Your prescriber will start you at a low dose and adjust gradually — do not change your dose on your own
  • If you also take colesevelam, take glimepiride at least 4 hours before your colesevelam dose
  • Patients with kidney problems or older adults should be started at the lowest available dose and increased slowly
Available strengths 6 strengths
1 mg 2 mg 3 mg 4 mg 6 mg 8 mg
193 FDA-listed product records ⓘ

Glimepiride on the U.S. market: products, makers and brands

How Glimepiride appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

27 companies list 104 Glimepiride product records with the FDA, mostly as tablet; the earliest marketing or approval year on record is 1995. Brand names on the directory include Amaryl; the rest are generics.

1
Dose forms ⓘ
27
Labelers (makers, repackagers, distributors)
2
Brand names
104
FDA-listed product records ⓘ
1995
Earliest FDA record ⓘ

Also listed with the FDA, not a patient dose form: Powder (10) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

A-S Medication Solutions13%
Bryant Ranch Prepack10%
PD-Rx Pharmaceuticals, Inc.10%
Proficient Rx LP7%
Micro Labs Limited6%
Northwind Health Company, LLC5%
Other makers50%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Glimepiride is used (Medicaid data)

A general measure of how commonly Glimepiride is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Glimepiride is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

630,394
Medicaid prescriptions filled (Q1–Q4 2025)
$6.9M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Glimepiride prescribed? Of the 1,601 medications we measure, Glimepiride ranks #232 by Medicaid prescriptions — more than 86% of them.

Where Glimepiride ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #232 of 1,601
#227 Pravastatin 660,709 Rx #228 Rivaroxaban 655,610 Rx #229 Polymyxin B and Trimet... 651,823 Rx #230 Magnesium Oxide 648,844 Rx #231 Alendronate 645,853 Rx #232 Glimepiride 630,394 Rx #233 Doxepin (Insomnia) 628,470 Rx #234 Doxepin (Depression, A... 628,470 Rx #235 Doxepin 628,470 Rx #236 Ropinirole 626,420 Rx #237 Valsartan 609,824 Rx

Utilization by Glimepiride product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 4 mg oral tablet is the most-dispensed Glimepiride product — about 48% of these Medicaid prescriptions.

glimepiride 4 MG Oral Tablet Most dispensed

302,985 Medicaid prescriptions (Q1–Q4 2025) 48% of Glimepiride prescriptions shown $3.1M gross reimbursement (before rebates) ≈ $10 per prescription (gross)

Summed across the 15 of 160 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 199247

glimepiride 2 MG Oral Tablet

224,368 Medicaid prescriptions (Q1–Q4 2025) 36% of Glimepiride prescriptions shown $2.1M gross reimbursement (before rebates) ≈ $9.32 per prescription (gross)

Summed across the 14 of 157 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 199246

glimepiride 1 MG Oral Tablet

102,271 Medicaid prescriptions (Q1–Q4 2025) 16% of Glimepiride prescriptions shown $837,512 gross reimbursement (before rebates) ≈ $8.19 per prescription (gross)

Summed across the 12 of 97 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 199245

glimepiride 3 MG Oral Tablet

770 Medicaid prescriptions (Q1–Q4 2025) <1% of Glimepiride prescriptions shown $810,822 gross reimbursement (before rebates) ≈ $1,053 per prescription (gross)

Summed across the 1 of 3 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 153842

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Glimepiride, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 42 of 417 listed Glimepiride NDCs with Medicaid activity.

Compare Glimepiride products

A representative set of FDA-listed product records for Glimepiride — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 104 of 104 products — FDA National Drug Code Directory. See every product, package size and price: browse all 104 Glimepiride NDCs →

Glimepiride recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list 3 Glimepiride recalls since July 2021, covering 7 product listings. Two of them are still ongoing or began in the last six months and are listed first. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.

Ongoing Class III Jan 18, 2024 · Dr. Reddy's Laboratories, Inc.
Misprint on tablet
  • Glimepiride Tablets, USP 1mg, 500-count bottles, Rx Only, Mfd. By: Dr. Reddy's Laboratories Limited, Srikakulam-532 409 INDIA, NDC: 55111-320-05 Lots: Lot: T2303609; Exp. 06/2026 Lot: T2303610; Exp. 06/2026 FDA record D-0313-2024 →
  • Glimepiride Tablets, USP 1mg, 100-count bottles, Rx Only, Mfd. By: Dr. Reddy's Laboratories Limited, Srikakulam-532 409 INDIA, NDC: 55111-320-01 Lots: Lot: T2303622; Exp. 06/2026 Lot: T2303626; Exp. 06/2026 Lot: T2303627; Exp. 06/2026 Lot: T2303628; Exp. 06/2026 Lot: T2303629; Exp. 06/2026 FDA record D-0312-2024 →
Ongoing Class II Mar 16, 2023 · Northwind Pharmaceuticals LLC
CGMP Deviations
  • Glimepiride Tablets, USP 4mg, packaged in a) 30-count bottles (NDC 51655-120-52), and b) 90-count bottles (NDC 51655-120-26), Rx Only, Repackaged By: Northwind Pharmaceuticals, Indianapolis, IN 46203. Lots: a) Lot #: F105692201, Exp. Date 09/30/2024; F105692203, Exp. Date 02/28/2025 b) Lot #: F105692202, Exp. Date 02/28/2025 FDA record D-0552-2023 →
  • Glimepiride Tablets, USP 2mg, packaged in a) 30-count bottles (NDC 51655-383-52), and b)90-count bottles (NDC 51655-383-26), Rx Only, Repackaged By: Northwind Pharmaceuticals, Indianapolis, IN 46203. Lots: a) Lot #: F106252201, Exp. Date 09/30/2024; F106252301, F106252303, Exp. Date 5/31/2025; F106252304, Exp. Date 07/31/2025 b) Lot #: F106252302, Exp. Date 07/31/2025 FDA record D-0551-2023 →
Class II Feb 7, 2023 · Terminated · Accord Healthcare, Inc.
CGMP Deviations: recalling drug products following an FDA inspection.
  • Glimepiride Tablets USP, 4 mg, Rx Only, Packaged in: a) 100-count bottle NDC 16729-003-01 UPC 3 16729 00301 8; b) 500-count NDC 16729-003-16 UPC 3 16729 00316 2; Manufactured for: Accord Healthcare,… Lots: Batches: a) P2001868, Exp. Date 3/31/2023, P2001869 Exp. Date 3/31/2023, P2002810 Exp. Date 5/31/2023, P2005473 Exp. Date 8/31/2023, P2005552 Exp. Date 9/30/2023, P2101986 Exp. Date 3/31/2024, P2101989 Exp. Date 3/31/2024, P2101988 Exp. Da… FDA record D-0395-2023 →
  • Glimepiride Tablets USP, 2 mg, Rx Only, Packaged in: a) 100 Tablets NDC 16729-002-01 UPC 3 16729 00201 1; b) 500 Tablets NDC 16729-002-16 UPC 3 16729 00216 5; Manufactured for: Accord Healthcare, Inc… Lots: Batches: a) R2000184, Exp. Date 4/30/2023, R2000183 Exp. Date 4/30/2023, P2002969 Exp. Date 5/31/2023, P2002970 Exp. Date 5/31/2023, P2005346 Exp. Date 8/31/2023, P2005847 Exp. Date 10/31/2023, P2006133 Exp. Date 10/31/2023, P2100682 Exp.… FDA record D-0394-2023 →
  • Glimepiride Tablets USP, 1 mg, Rx Only, Packaged in: a) 100-count bottle NDC 16729-001-01 UPC 3 16729 00101 4; b) 500-count bottle NDC 16729-001-16 UPC 3 16729 00116 8; Manufactured for: Accord Healt… Lots: Batches: a) R2000166, Exp. Date 4/30/2023, P2003528 Exp. Date 6/30/2023, P2005451 Exp. Date 8/31/2023, P2005438 Exp. Date 8/31/2023, P2005436 Exp. Date 8/31/2023, P2005437 Exp. Date 8/31/2023, P2005452 Exp. Date 8/31/2023, P2006055 Exp. Da… FDA record D-0393-2023 →

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Glimepiride RxCUI 25789 1 dose form · 6 strengths
  1. Dose form (SCDF) Oral Tablet RxCUI 372319 In current FDA listings
    Clinical drug / strength (SCD) 1 MG RxCUI 199245 2 MG RxCUI 199246 3 MG RxCUI 153842 4 MG RxCUI 199247 6 MG RxCUI 1361493 8 MG RxCUI 1361495

Look up RxCUI 25789 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

Glimepiride brand names

Glimepiride is sold under one brand name in the FDA directory — Amaryl. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Amaryl

Who makes Glimepiride: manufacturers and labelers

27 companies list Glimepiride products with the FDA. By number of product records, the largest are A-S Medication Solutions, Bryant Ranch Prepack, PD-Rx Pharmaceuticals, Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

A-S Medication Solutions 14 Bryant Ranch Prepack 10 PD-Rx Pharmaceuticals, Inc. 10 Proficient Rx LP 7 Micro Labs Limited 6 Northwind Health Company, LLC 5 Accord Healthcare Inc 3 American Health Packaging 3 Aurobindo Pharma Limited 3 AvPAK 3 BluePoint Laboratories 3 Carlsbad Technology, Inc. 3 Dr. Reddy's Laboratories Limited 3 Florida Pharmaceutical Products, LLC 3 Golden State Medical Supply, Inc. 3 NCS HealthCare of KY, Inc dba Vangard Labs 3 NuCare Pharmaceuticals,Inc. 3 Preferred Pharmaceuticals Inc. 3 Rising Pharma Holdings, Inc. 3 Solco Healthcare U.S., LLC 3 Direct_Rx 2 Remedyrepack Inc. 2 St. Mary's Medical Park Pharmacy 2 Aphena Pharma Solutions - Tennessee, LLC 1

…and 3 more on the FDA NDC directory.

Sources for this Glimepiride page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Jan 25, 2018
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Glimepiride.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Glimepiride after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
79
Finished products in the current FDA directory
104
Companies listing them (makers, repackagers, distributors)
27
FDA labeler codes behind them ⓘ
32
Linked representative label ⓘ
International Laboratories, LLC
Linked label effective
Jan 25, 2018
Composite sections available
23
Linked SPL Set ID
1873bce1-172f-4eb0-b5bc-cb7d444a8d8e
Linked SPL Document ID
061c5497-cc54-4874-b5db-81d99d9cfb71
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. International Laboratories, LLC is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →