Doxepin (Insomnia)

Generic name: Pronounced as (dox' e pin)
Brand names
  • Silenor®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 05/24/2017

Doxepin (Silenor) is used to treat insomnia (difficulty falling asleep or staying asleep) in people who have trouble staying asleep. Doxepin (Silenor) is in a class of medications called tricyclic antidepressants. It works by slowing activity in the brain to allow sleep.

Doxepin is also available as a capsule and liquid to treat depression and anxiety. This monograph only gives information about doxepin (Silenor) for insomnia. If you are using this medication for depression or anxiety, read the monograph entitled doxepin (depression, anxiety).

Doxepin (Silenor) comes as a tablet to take by mouth. It is usually taken once a day, within 30 minutes of bedtime. Do not take doxepin (Silenor) within 3 hours of a meal. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take doxepin (Silenor) exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

You will probably become very sleepy soon after you take doxepin (Silenor) and will remain sleepy for some time after you take the medication. Plan to go to bed right after you take doxepin (Silenor) and to stay in bed for 7 to 8 hours. Do not take doxepin (Silenor) if you will be unable to go to bed right away and remain asleep for 7 to 8 hours after taking the medication.

You should begin to sleep better during the first few days of treatment with doxepin (Silenor). If your sleep does not improve within 7-10 days, or gets worse call your doctor.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with doxepin (Silenor) and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking doxepin (Silenor),

  • tell your doctor and pharmacist if you are allergic to doxepin (Silenor), amoxapine, loxapine, any other medications, or any of the ingredients in doxepin (Silenor) tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor if you are taking a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking an MAO inhibitor within the past 14 days. Also tell your doctor if you are taking or receiving methylene blue (Provayblue) or linezolid (Zyvox). Your doctor will probably tell you not to take doxepin. If you stop taking doxepin, you should wait at least 14 days before you start to take an MAO inhibitor.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: cimetidine (Tagamet); medications for cough, cold, or allergies; quinidine (in Nuedexta); sedatives; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); other sleeping pills; tolazamide; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with doxepin (Silenor), so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor if you have or have ever had glaucoma that is not being treated, or urinary retention (inability to empty your bladder completely or at all). Your doctor may tell you not to take doxepin (Silenor).

  • tell your doctor if you have or have ever drunk large amounts of alcohol, used street drugs, or over-used prescription medications. Also tell your doctor if you have or have ever had depression, mental illness, suicidal thoughts, sleep apnea (a sleep disorder that causes breathing to stop for short periods during sleep), or kidney or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking doxepin (Silenor), call your doctor.

  • you should know that doxepin (Silenor) may make you drowsy. Do not drive a car, operate machinery, or do other dangerous activities at night after taking doxepin (Silenor). Do not drive a car or operate machinery the next day until you know how this medication affects you.

  • you should know that alcohol can add to the drowsiness caused by this medication. Do not drink alcohol while you are taking doxepin (Silenor).

  • you should know that some people who took doxepin (Silenor) got out of bed and drove their cars, prepared and ate food, had sex, made phone calls, were sleep-walking, or were involved in other activities while not fully awake. After they woke up, these people were usually unable to remember what they had done. Call your doctor right away if you find out that you have been driving or doing anything else unusual while you were sleeping.

Unless your doctor tells you otherwise, continue your normal diet.

Doxepin (Silenor) should only be taken at bedtime. If you did not take doxepin (Silenor) before you went to bed and you are having trouble sleeping, you may take doxepin (Silenor) if you will be able to stay in bed for at least 7 to 8 hours afterward. Do not take a double dose of doxepin (Silenor) to make up for a missed dose.

  • Doxepin (Silenor) may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • dizziness

  • Doxepin (Silenor) may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, and excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • irregular heart beat

  • feeling agitated, confused, or drowsy

  • trouble concentrating

  • seizures

  • muscle stiffness

  • vomiting

  • increase in pupil size

  • hallucination (seeing things or hearing voices that do not exist)

  • fever

  • cold body temperature

  • coma (loss of consciousness for a period of time)

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The metabolism of Doxepin can be decreased when combined with Moxifloxacin.
Repaglinide Repaglinide Doxepin may decrease the hypoglycemic activities of Repaglinide.
Montelukast Montelukast The metabolism of Doxepin can be decreased when combined with Montelukast.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The metabolism of Doxepin can be increased when combined with Insulin glargine.
Leflunomide Leflunomide The serum concentration of Doxepin can be decreased when it is combined with Leflunomide.
Delavirdine Delavirdine Doxepin can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nevirapine Nevirapine The metabolism of Doxepin can be decreased when combined with Nevirapine.
Dolasetron Dolasetron Dolasetron may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Doxepin.
Anagrelide Anagrelide The metabolism of Doxepin can be decreased when combined with Anagrelide.
Bisacodyl Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Doxepin.
Candesartan Candesartan The metabolism of Doxepin can be decreased when combined with Candesartan.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Doxepin.
Clopidogrel Clopidogrel The metabolism of Doxepin can be decreased when combined with Clopidogrel.
Diphenoxylate Diphenoxylate The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Doxepin.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The risk or severity of QTc prolongation can be increased when Doxepin is combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The metabolism of Doxepin can be decreased when combined with Conjugated estrogens.
Fenofibrate Fenofibrate The metabolism of Doxepin can be decreased when combined with Fenofibrate.
Guanfacine Guanfacine Guanfacine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Magnesium Hydroxide Magnesium Hydroxide Doxepin may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Magnesium Oxide Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Doxepin.
Methylergonovine Methylergonovine The risk or severity of hypertension can be increased when Methylergometrine is combined with Doxepin.
Miglitol Miglitol Doxepin may decrease the hypoglycemic activities of Miglitol.
Mycophenolate Mycophenolate Mycophenolic acid may decrease the excretion rate of Doxepin which could result in a higher serum level.
Naratriptan Naratriptan The risk or severity of adverse effects can be increased when Naratriptan is combined with Doxepin.
Olsalazine Olsalazine Doxepin may decrease the excretion rate of Olsalazine which could result in a higher serum level.
Paregoric Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Doxepin.
Penbutolol Penbutolol The metabolism of Acebutolol can be decreased when combined with Doxepin.
Pentazocine Pentazocine The risk or severity of adverse effects can be increased when Pentazocine is combined with Doxepin.
Polyethylene glycol-electrolyte solution (PEG-ES) Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Doxepin.
Potassium Potassium Potassium may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone Prednisone may decrease the excretion rate of Doxepin which could result in a higher serum level.
Psyllium Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Doxepin.
Ranitidine Ranitidine The metabolism of Doxepin can be decreased when combined with Ranitidine.
Reserpine Reserpine Reserpine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Rizatriptan Rizatriptan Rizatriptan may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Sumatriptan Sumatriptan Sumatriptan may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Tacrolimus Tacrolimus Tacrolimus may decrease the excretion rate of Doxepin which could result in a higher serum level.
Tizanidine Tizanidine Tizanidine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Zolmitriptan Zolmitriptan The metabolism of Doxepin can be decreased when combined with Zolmitriptan.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Doxepin which could result in a higher serum level.
Famotidine Injection Famotidine Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Doxepin.
Fluconazole Injection Fluconazole Injection The metabolism of Doxepin can be decreased when combined with Fluconazole.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Doxepin which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Doxepin.
Interferon Beta-1b Injection Interferon Beta-1b Injection The metabolism of Doxepin can be decreased when combined with Interferon beta-1b.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The metabolism of Doxepin can be decreased when combined with Interferon gamma-1b.
Levofloxacin Injection Levofloxacin Injection The metabolism of Doxepin can be decreased when combined with Levofloxacin.
Meperidine Injection Meperidine Injection The risk or severity of adverse effects can be increased when Meperidine is combined with Doxepin.
Metoclopramide Injection Metoclopramide Injection The risk or severity of sedation can be increased when Metoclopramide is combined with Doxepin.
Metronidazole Injection Metronidazole Injection The metabolism of Doxepin can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Doxepin.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Doxepin which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Doxepin may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The metabolism of Doxepin can be decreased when combined with Zidovudine.
Altretamine Altretamine Amphetamine may decrease the sedative and stimulatory activities of Doxepin.
Cefuroxime Cefuroxime Doxepin can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cyclosporine Cyclosporine The metabolism of Doxepin can be decreased when combined with Cyclosporine.
Ondansetron Ondansetron Ondansetron may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Granisetron Granisetron The risk or severity of QTc prolongation can be increased when Doxepin is combined with Granisetron.
Torsemide Torsemide The metabolism of Doxepin can be decreased when combined with Torasemide.
Olanzapine Olanzapine Olanzapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Alosetron Alosetron Alosetron may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Dofetilide Dofetilide The risk or severity of QTc prolongation can be increased when Doxepin is combined with Dofetilide.
Entacapone Entacapone Entacapone may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Eprosartan Eprosartan Doxepin may decrease the antihypertensive activities of Eprosartan.
Hydroxychloroquine Hydroxychloroquine The metabolism of Doxepin can be decreased when combined with Hydroxychloroquine.
Meloxicam Meloxicam Meloxicam may decrease the excretion rate of Doxepin which could result in a higher serum level.
Oxcarbazepine Oxcarbazepine Oxcarbazepine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Pantoprazole Pantoprazole The metabolism of Doxepin can be decreased when combined with Pantoprazole.
Risedronate Risedronate Doxepin can cause an increase in the absorption of Risedronic acid resulting in an increased serum concentration and potentially a worsening of adverse effects.
Telmisartan Telmisartan The metabolism of Doxepin can be decreased when combined with Telmisartan.
Temozolomide Temozolomide Temozolomide may decrease the excretion rate of Doxepin which could result in a higher serum level.
Zaleplon Zaleplon Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Anakinra Anakinra The metabolism of Doxepin can be increased when combined with Anakinra.
Desloratadine Desloratadine Desloratadine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Linezolid Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Doxepin.
Rivastigmine Rivastigmine The therapeutic efficacy of Doxepin can be decreased when used in combination with Rivastigmine.
Trimipramine Trimipramine Trimipramine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Etanercept Injection Etanercept Injection The metabolism of Doxepin can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate The risk or severity of adverse effects can be increased when Doxepin is combined with Glycopyrronium.
Modafinil Modafinil The metabolism of Doxepin can be decreased when combined with Modafinil.
Perindopril Perindopril Doxepin may decrease the antihypertensive activities of Perindopril.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Doxepin which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Doxepin may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.
Dutasteride Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Doxepin.
Epinephrine Injection Epinephrine Injection Epinephrine may increase the vasopressor activities of Doxepin.
Eplerenone Eplerenone Doxepin may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram Escitalopram The risk or severity of serotonin syndrome can be increased when Doxepin is combined with Escitalopram.
Olmesartan Olmesartan Doxepin may decrease the antihypertensive activities of Olmesartan.
Zonisamide Zonisamide Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Adalimumab Injection Adalimumab Injection The metabolism of Doxepin can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole.
Atomoxetine Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Doxepin.
Dexmethylphenidate Dexmethylphenidate The serum concentration of Doxepin can be increased when it is combined with Dexmethylphenidate.
Atazanavir Atazanavir Doxepin can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Almotriptan Almotriptan Almotriptan may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Eletriptan Eletriptan Eletriptan may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Mefloquine Mefloquine The risk or severity of QTc prolongation can be increased when Mefloquine is combined with Doxepin.
Polyethylene Glycol 3350 Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Doxepin.
Rosuvastatin Rosuvastatin The metabolism of Doxepin can be decreased when combined with Rosuvastatin.
Vardenafil Vardenafil The risk or severity of QTc prolongation can be increased when Vardenafil is combined with Doxepin.
Alfuzosin Alfuzosin Alfuzosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Aprepitant Aprepitant The metabolism of Doxepin can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine Emtricitabine may decrease the excretion rate of Doxepin which could result in a higher serum level.
Interferon Beta-1a Subcutaneous Injection Interferon Beta-1a Subcutaneous Injection The metabolism of Doxepin can be decreased when combined with Interferon beta-1a.
Memantine Memantine The metabolism of Doxepin can be decreased when combined with Memantine.
Tegaserod Tegaserod The metabolism of Doxepin can be decreased when combined with Tegaserod.
Tadalafil Tadalafil The risk or severity of hypotension, dyspepsia, and headache can be increased when Doxepin is combined with Tadalafil.
Fosamprenavir Fosamprenavir Doxepin can cause a decrease in the absorption of Fosamprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Frovatriptan Frovatriptan The metabolism of Doxepin can be decreased when combined with Frovatriptan.
Gemifloxacin Gemifloxacin The metabolism of Doxepin can be decreased when combined with Gemifloxacin.
Progesterone Progesterone The metabolism of Doxepin can be decreased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Doxepin.
Infliximab Injection Infliximab Injection The metabolism of Doxepin can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Doxepin can be decreased when combined with Oxandrolone.
Protriptyline Protriptyline Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Rifaximin Rifaximin The metabolism of Doxepin can be increased when combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Doxepin can be decreased when combined with Duloxetine.
Tinidazole Tinidazole Tinidazole may decrease the excretion rate of Doxepin which could result in a higher serum level.
Trospium Trospium Doxepin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan Bosentan The metabolism of Doxepin can be increased when combined with Bosentan.
Cefditoren Cefditoren Cefdinir may decrease the excretion rate of Doxepin which could result in a higher serum level.
Cinacalcet Cinacalcet The metabolism of Doxepin can be decreased when combined with Cinacalcet.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Erlotinib Erlotinib Doxepin can cause a decrease in the absorption of Erlotinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Eszopiclone Eszopiclone The risk or severity of CNS depression can be increased when Doxepin is combined with Eszopiclone.
Ganciclovir Ganciclovir Ganciclovir may decrease the excretion rate of Doxepin which could result in a higher serum level.
Insulin Aspart (rDNA Origin) Injection Insulin Aspart (rDNA Origin) Injection Doxepin may decrease the hypoglycemic activities of Insulin aspart.
Ribavirin Ribavirin Ribavirin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Solifenacin Solifenacin Doxepin may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Valganciclovir Valganciclovir Doxepin may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole Voriconazole The metabolism of Doxepin can be decreased when combined with Voriconazole.
Adefovir Adefovir Adefovir may decrease the excretion rate of Doxepin which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Amphetamine may decrease the sedative and stimulatory activities of Doxepin.
Entecavir Entecavir The metabolism of Doxepin can be decreased when combined with Entecavir.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The metabolism of Doxepin can be decreased when combined with Peginterferon alfa-2a.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The serum concentration of Doxepin can be increased when it is combined with Peginterferon alfa-2b.
Pramlintide Injection Pramlintide Injection The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Doxepin.
Sodium Oxybate Sodium Oxybate Doxepin may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Exenatide Injection Exenatide Injection Doxepin may decrease the hypoglycemic activities of Exenatide.
Ibandronate Ibandronate The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Doxepin.
Isocarboxazid Isocarboxazid Doxepin may increase the serotonergic activities of Isocarboxazid.
Ramelteon Ramelteon Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Darifenacin Darifenacin The metabolism of Doxepin can be decreased when combined with Darifenacin.
Fentanyl Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Doxepin.
Pregabalin Pregabalin The therapeutic efficacy of Doxepin can be increased when used in combination with Pregabalin.
Deferasirox Deferasirox The serum concentration of Doxepin can be increased when it is combined with Deferasirox.
Phenylephrine Phenylephrine Doxepin may increase the vasopressor activities of Phenylephrine.
Tipranavir Tipranavir The metabolism of Doxepin can be decreased when combined with Tipranavir.
Felbamate Felbamate The metabolism of Doxepin can be decreased when combined with Felbamate.
Insulin Detemir (rDNA Origin) Injection Insulin Detemir (rDNA Origin) Injection Doxepin may decrease the hypoglycemic activities of Insulin detemir.
Ranolazine Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Doxepin.
Abatacept Injection Abatacept Injection The metabolism of Doxepin can be increased when combined with Abatacept.
Rasagiline Rasagiline Rasagiline may increase the serotonergic activities of Doxepin.
Imatinib Imatinib The metabolism of Doxepin can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin Doxepin may decrease the hypoglycemic activities of Sitagliptin.
Varenicline Varenicline Doxepin may decrease the excretion rate of Varenicline which could result in a higher serum level.
Gefitinib Gefitinib Doxepin can cause a decrease in the absorption of Gefitinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Albuterol Albuterol The risk or severity of QTc prolongation can be increased when Salbutamol is combined with Doxepin.
Paliperidone Paliperidone Paliperidone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Bortezomib Bortezomib The risk or severity of QTc prolongation can be increased when Bortezomib is combined with Doxepin.
Clofarabine Injection Clofarabine Injection Clofarabine may decrease the excretion rate of Doxepin which could result in a higher serum level.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The metabolism of Doxepin can be increased when combined with Insulin glulisine.
Lubiprostone Lubiprostone Doxepin may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of QTc prolongation can be increased when Doxepin is combined with Oxaliplatin.
Posaconazole Posaconazole The risk or severity of QTc prolongation can be increased when Doxepin is combined with Posaconazole.
Primaquine Primaquine The metabolism of Doxepin can be decreased when combined with Primaquine.
Aliskiren Aliskiren Doxepin may decrease the antihypertensive activities of Aliskiren.
Bismuth Subsalicylate Bismuth Subsalicylate Doxepin may increase the neurotoxic activities of Bismuth subsalicylate.
Pemetrexed Injection Pemetrexed Injection Pemetrexed may decrease the excretion rate of Doxepin which could result in a higher serum level.
Dimenhydrinate Dimenhydrinate Dimenhydrinate may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Lisdexamfetamine Lisdexamfetamine Lisdexamfetamine may decrease the sedative and stimulatory activities of Doxepin.
Nabilone Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Vorinostat Vorinostat The risk or severity of QTc prolongation can be increased when Doxepin is combined with Vorinostat.
Sorafenib Sorafenib The metabolism of Doxepin can be decreased when combined with Sorafenib.
Sunitinib Sunitinib Doxepin may decrease the hypoglycemic activities of Sunitinib.
Dronabinol Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Lapatinib Lapatinib The risk or severity of QTc prolongation can be increased when Doxepin is combined with Lapatinib.
Levocetirizine Levocetirizine Levocetirizine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Pegaptanib Injection Pegaptanib Injection Doxepin may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib Dasatinib Doxepin can cause a decrease in the absorption of Dasatinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Mexiletine Mexiletine The metabolism of Doxepin can be decreased when combined with Mexiletine.
Armodafinil Armodafinil The metabolism of Doxepin can be decreased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection Azacitidine may decrease the excretion rate of Doxepin which could result in a higher serum level.
Paclitaxel (with polyoxyethylated castor oil) Injection Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Doxepin.
Temsirolimus Temsirolimus The metabolism of Doxepin can be decreased when combined with Temsirolimus.
Lenalidomide Lenalidomide Lenalidomide may decrease the excretion rate of Doxepin which could result in a higher serum level.
Nilotinib Nilotinib Doxepin can cause a decrease in the absorption of Nilotinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Toremifene Toremifene The risk or severity of QTc prolongation can be increased when Doxepin is combined with Toremifene.
Bexarotene Bexarotene The metabolism of Doxepin can be decreased when combined with Bexarotene.
Budesonide Budesonide Budesonide can cause a decrease in the absorption of Doxepin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Doxepin can be decreased when combined with Chloramphenicol.
Desmopressin Desmopressin The risk or severity of hyponatremia and water intoxication can be increased when Doxepin is combined with Desmopressin.
Betaine Betaine The therapeutic efficacy of Doxepin can be decreased when used in combination with Glycine betaine.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Doxepin is combined with Botulinum toxin type A.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Doxepin is combined with Botulinum Toxin Type B.
Doripenem Injection Doripenem Injection Doxepin may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine Etravirine The metabolism of Doxepin can be decreased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Doxepin is combined with Arsenic trioxide.
Desvenlafaxine Desvenlafaxine The risk or severity of adverse effects can be increased when Doxepin is combined with Desvenlafaxine.
Cevimeline Cevimeline The metabolism of Cevimeline can be decreased when combined with Doxepin.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Doxepin.
Tretinoin Tretinoin The metabolism of Doxepin can be decreased when combined with Tretinoin.
Bendamustine Injection Bendamustine Injection The metabolism of Bendamustine can be decreased when combined with Doxepin.
Flecainide Flecainide The metabolism of Flecainide can be decreased when combined with Doxepin.
Certolizumab Injection Certolizumab Injection The metabolism of Doxepin can be increased when combined with Certolizumab pegol.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Praziquantel Praziquantel The metabolism of Doxepin can be decreased when combined with Praziquantel.
Methylnaltrexone Injection Methylnaltrexone Injection Doxepin may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Rufinamide Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Doxepin.
Silodosin Silodosin Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Silodosin.
Midazolam Midazolam Midazolam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Naltrexone Injection Naltrexone Injection The risk or severity of adverse effects can be increased when Naltrexone is combined with Doxepin.
Dexrazoxane Injection Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Doxepin which could result in a higher serum level.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Doxepin.
Milnacipran Milnacipran The risk or severity of adverse effects can be increased when Doxepin is combined with Milnacipran.
Dexlansoprazole Dexlansoprazole The metabolism of Doxepin can be decreased when combined with Dexlansoprazole.
Plerixafor Injection Plerixafor Injection Doxepin may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Sodium Phosphate Sodium Phosphate The risk or severity of seizure can be increased when Doxepin is combined with Sodium phosphate, monobasic.
Fesoterodine Fesoterodine Doxepin may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Degarelix Injection Degarelix Injection The risk or severity of QTc prolongation can be increased when Doxepin is combined with Degarelix.
Betaxolol Betaxolol The metabolism of Doxepin can be decreased when combined with Betaxolol.
Iloperidone Iloperidone Iloperidone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Prasugrel Prasugrel Doxepin may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Lacosamide Lacosamide Doxepin may increase the central nervous system depressant (CNS depressant) activities of Lacosamide.
Everolimus Everolimus The metabolism of Doxepin can be decreased when combined with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy.
Dronedarone Dronedarone Doxepin may increase the QTc-prolonging activities of Dronedarone.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Doxepin is combined with Botulinum toxin type A.
Pralatrexate Injection Pralatrexate Injection Doxepin may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Saxagliptin Saxagliptin Doxepin may decrease the hypoglycemic activities of Saxagliptin.
Telavancin Injection Telavancin Injection The risk or severity of QTc prolongation can be increased when Doxepin is combined with Telavancin.
Romidepsin Injection Romidepsin Injection The risk or severity of QTc prolongation can be increased when Doxepin is combined with Romidepsin.
Tapentadol Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Topotecan Topotecan Topotecan may decrease the excretion rate of Doxepin which could result in a higher serum level.
Golimumab Injection Golimumab Injection The metabolism of Doxepin can be increased when combined with Golimumab.
Pazopanib Pazopanib The therapeutic efficacy of Pazopanib can be decreased when used in combination with Doxepin.
Asenapine Asenapine Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Asenapine.
Vigabatrin Vigabatrin Vigabatrin may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Doxepin.
Albendazole Albendazole The metabolism of Doxepin can be decreased when combined with Albendazole.
Oxymorphone Oxymorphone The risk or severity of adverse effects can be increased when Doxepin is combined with Oxymorphone.
Liraglutide Injection Liraglutide Injection Doxepin may decrease the hypoglycemic activities of Liraglutide.
Tocilizumab Injection Tocilizumab Injection The metabolism of Doxepin can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine The risk or severity of seizure can be increased when Dalfampridine is combined with Doxepin.
Eribulin Injection Eribulin Injection The risk or severity of QTc prolongation can be increased when Doxepin is combined with Eribulin.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Doxepin is combined with Botulinum toxin type A.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Doxepin which could result in a higher serum level.
Lurasidone Lurasidone Doxepin may increase the hypotensive activities of Lurasidone.
Acetaminophen Injection Acetaminophen Injection The metabolism of Doxepin can be decreased when combined with Acetaminophen.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Doxepin.
Ipilimumab Injection Ipilimumab Injection Doxepin may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection The therapeutic efficacy of Doxepin can be decreased when used in combination with Terbutaline.
Roflumilast Roflumilast Doxepin may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Linagliptin Linagliptin Doxepin may decrease the hypoglycemic activities of Linagliptin.
Rilpivirine Rilpivirine Doxepin can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Potassium Iodide Potassium Iodide The risk or severity of Cardiac Arrhythmia can be increased when Potassium Iodide is combined with Doxepin.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Doxepin can be decreased when combined with Cyclophosphamide.
Abiraterone Abiraterone The serum concentration of Doxepin can be increased when it is combined with Abiraterone.
Triptorelin Injection Triptorelin Injection The risk or severity of QTc prolongation can be increased when Doxepin is combined with Triptorelin.
Rivaroxaban Rivaroxaban Doxepin may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor Ticagrelor The metabolism of Doxepin can be decreased when combined with Ticagrelor.
Ruxolitinib Ruxolitinib Doxepin may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Vandetanib Vandetanib The risk or severity of QTc prolongation can be increased when Doxepin is combined with Vandetanib.
Clobazam Clobazam The metabolism of Doxepin can be decreased when combined with Clobazam.
Vemurafenib Vemurafenib The serum concentration of Doxepin can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Doxepin can be decreased when combined with Vismodegib.
Deferiprone Deferiprone Doxepin may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Doxepin.
Crizotinib Crizotinib The risk or severity of QTc prolongation can be increased when Doxepin is combined with Crizotinib.
Cabergoline Cabergoline Cabergoline may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Naloxone Injection Naloxone Injection Doxepin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ambrisentan Ambrisentan Doxepin may decrease the antihypertensive activities of Ambrisentan.
Fondaparinux Injection Fondaparinux Injection Fondaparinux may decrease the excretion rate of Doxepin which could result in a higher serum level.
Ezogabine Ezogabine Tiagabine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Enzalutamide Enzalutamide The metabolism of Doxepin can be increased when combined with Enzalutamide.
Mirabegron Mirabegron The risk or severity of urinary retention can be increased when Doxepin is combined with Mirabegron.
Regorafenib Regorafenib The metabolism of Doxepin can be decreased when combined with Regorafenib.
Bosutinib Bosutinib Doxepin can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Linaclotide Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Doxepin.
Teriflunomide Teriflunomide The serum concentration of Doxepin can be decreased when it is combined with Teriflunomide.
Lorcaserin Lorcaserin Doxepin may decrease the hypoglycemic activities of Mecasermin.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Doxepin.
Teduglutide Injection Teduglutide Injection Doxepin may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Bedaquiline Bedaquiline The risk or severity of QTc prolongation can be increased when Doxepin is combined with Bedaquiline.
Alogliptin Alogliptin The metabolism of Alogliptin can be decreased when combined with Doxepin.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Doxepin.
Pomalidomide Pomalidomide Pomalidomide may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Doxepin.
Canagliflozin Canagliflozin Doxepin may decrease the hypoglycemic activities of Canagliflozin.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib Dabrafenib The serum concentration of Doxepin can be decreased when it is combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Doxepin.
Trametinib Trametinib Doxepin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran The risk or severity of adverse effects can be increased when Doxepin is combined with Levomilnacipran.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Doxepin which could result in a higher serum level.
Vortioxetine Vortioxetine Doxepin may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Perampanel Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Doxepin.
Avanafil Avanafil The risk or severity of hypotension, dyspepsia, and headache can be increased when Avanafil is combined with Doxepin.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the excretion rate of Doxepin which could result in a higher serum level.
Simeprevir Simeprevir The metabolism of Doxepin can be decreased when combined with Simeprevir.
Sofosbuvir Sofosbuvir Doxepin may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Doxepin.
Iron Sucrose Injection Iron Sucrose Injection Doxepin can cause a decrease in the absorption of Iron sucrose resulting in a reduced serum concentration and potentially a decrease in efficacy.
Apremilast Apremilast The metabolism of Doxepin can be increased when combined with Apremilast.
Droxidopa Droxidopa Doxepin may increase the vasopressor activities of Droxidopa.
Ceritinib Ceritinib The metabolism of Doxepin can be decreased when combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Doxepin can be increased when combined with Siltuximab.
Albiglutide Injection Albiglutide Injection Doxepin may decrease the hypoglycemic activities of Albiglutide.
Eslicarbazepine Eslicarbazepine Eslicarbazepine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Belinostat Injection Belinostat Injection The metabolism of Doxepin can be increased when combined with Belinostat.
Testosterone Injection Testosterone Injection The metabolism of Doxepin can be decreased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Doxepin can be decreased when combined with Oritavancin.
Empagliflozin Empagliflozin Doxepin may decrease the hypoglycemic activities of Empagliflozin.
Hydrocodone Hydrocodone Hydrocodone may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Suvorexant Suvorexant Doxepin may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Dulaglutide Injection Dulaglutide Injection Doxepin may decrease the hypoglycemic activities of Dulaglutide.
Edoxaban Edoxaban Doxepin may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The metabolism of Doxepin can be decreased when combined with Peginterferon beta-1a.
Methamphetamine Methamphetamine Metamfetamine may decrease the sedative and stimulatory activities of Doxepin.
Tasimelteon Tasimelteon Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Riociguat Riociguat Doxepin may decrease the antihypertensive activities of Riociguat.
Pirfenidone Pirfenidone The metabolism of Pirfenidone can be decreased when combined with Doxepin.
Secukinumab Injection Secukinumab Injection The metabolism of Doxepin can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection Risperidone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Insulin Human Inhalation Insulin Human Inhalation The metabolism of Doxepin can be increased when combined with Insulin human.
Lenvatinib Lenvatinib The metabolism of Doxepin can be decreased when combined with Lenvatinib.
Naloxegol Naloxegol The metabolism of Doxepin can be decreased when combined with Naloxegol.
Panobinostat Panobinostat The metabolism of Doxepin can be decreased when combined with Panobinostat.
Haloperidol Injection Haloperidol Injection The serum concentration of Doxepin can be increased when it is combined with Haloperidol.
Ivabradine Ivabradine The risk or severity of QTc prolongation can be increased when Doxepin is combined with Ivabradine.
Amiloride Amiloride Amiloride may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy.
Isavuconazonium Injection Isavuconazonium Injection Doxepin can cause a decrease in the absorption of Isavuconazonium resulting in a reduced serum concentration and potentially a decrease in efficacy.
Macitentan Macitentan Doxepin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Flibanserin Flibanserin Flibanserin may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Rolapitant Rolapitant The metabolism of Doxepin can be decreased when combined with Rolapitant.
Brexpiprazole Brexpiprazole Brexpiprazole may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Ziprasidone Injection Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Ziprasidone is combined with Doxepin.
Cariprazine Cariprazine Cariprazine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Penicillin G Procaine Injection Penicillin G Procaine Injection Doxepin may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline Eluxadoline The risk or severity of constipation can be increased when Doxepin is combined with Eluxadoline.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The metabolism of Doxepin can be increased when combined with Insulin degludec.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Doxepin.
Osimertinib Osimertinib The serum concentration of Doxepin can be decreased when it is combined with Osimertinib.
Ixazomib Ixazomib Doxepin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Rifapentine Rifapentine The metabolism of Doxepin can be increased when combined with Rifapentine.
Lesinurad Lesinurad Doxepin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Doxepin which could result in a higher serum level.
Brivaracetam Injection Brivaracetam Injection Doxepin may increase the central nervous system depressant (CNS depressant) activities of Brivaracetam.
Cobicistat Cobicistat The metabolism of Doxepin can be decreased when combined with Cobicistat.
Midodrine Midodrine Midodrine may increase the vasopressor activities of Doxepin.
Selexipag Selexipag Doxepin may decrease the antihypertensive activities of Selexipag.
Pimavanserin Pimavanserin The risk or severity of adverse effects can be increased when Doxepin is combined with Pimavanserin.
Obeticholic Acid Obeticholic Acid The metabolism of Doxepin can be decreased when combined with Obeticholic acid.
Diphenhydramine Injection Diphenhydramine Injection Diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Furosemide Injection Furosemide Injection Doxepin may decrease the excretion rate of Furosemide which could result in a higher serum level.
Rucaparib Rucaparib The metabolism of Doxepin can be decreased when combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection Doxepin may decrease the hypoglycemic activities of Lixisenatide.
Ribociclib Ribociclib The risk or severity of QTc prolongation can be increased when Doxepin is combined with Ribociclib.
Plecanatide Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Doxepin.
Deutetrabenazine Deutetrabenazine The risk or severity of sedation and somnolence can be increased when Doxepin is combined with Deutetrabenazine.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Doxepin.
Safinamide Safinamide Safinamide may increase the serotonergic activities of Doxepin.
Naldemedine Naldemedine Doxepin may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Midostaurin Midostaurin The metabolism of Doxepin can be decreased when combined with Midostaurin.
Enasidenib Enasidenib The metabolism of Doxepin can be decreased when combined with Enasidenib.
Benznidazole Benznidazole Doxepin may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin The risk or severity of QTc prolongation can be increased when Delafloxacin is combined with Doxepin.
Letermovir Letermovir The metabolism of Letermovir can be decreased when combined with Doxepin.
Semaglutide Injection Semaglutide Injection Doxepin may decrease the hypoglycemic activities of Semaglutide.
Tetrabenazine Tetrabenazine The risk or severity of sedation and somnolence can be increased when Doxepin is combined with Tetrabenazine.
Ertugliflozin Ertugliflozin Doxepin may decrease the hypoglycemic activities of Ertugliflozin.
Buprenorphine Injection Buprenorphine Injection Doxepin may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide Apalutamide The serum concentration of Doxepin can be increased when it is combined with Apalutamide.
Fostamatinib Fostamatinib The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Doxepin.
Avatrombopag Avatrombopag The metabolism of Doxepin can be increased when combined with Avatrombopag.
Baricitinib Baricitinib Doxepin may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine The therapeutic efficacy of Doxepin can be increased when used in combination with Lofexidine.
Plazomicin Injection Plazomicin Injection Doxepin may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Doxepin.
Encorafenib Encorafenib The metabolism of Encorafenib can be decreased when combined with Doxepin.
Binimetinib Binimetinib The metabolism of Binimetinib can be decreased when combined with Doxepin.
Ivosidenib Ivosidenib The risk or severity of QTc prolongation can be increased when Doxepin is combined with Ivosidenib.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Doxepin.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Doxepin.
Cannabidiol Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Doxepin.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Doxepin.
Stiripentol Stiripentol The metabolism of Doxepin can be decreased when combined with Stiripentol.
Gilteritinib Gilteritinib The therapeutic efficacy of Doxepin can be decreased when used in combination with Gilteritinib.
Glasdegib Glasdegib The risk or severity of QTc prolongation can be increased when Doxepin is combined with Glasdegib.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Doxepin.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection Doxepin may increase the neurotoxic activities of Paclitaxel.
Rifamycin Rifamycin The metabolism of Doxepin can be increased when combined with Rifamycin.
Prucalopride Prucalopride Doxepin may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Magnesium Citrate Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Doxepin.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Doxepin can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Doxepin.
Acyclovir Ophthalmic Acyclovir Ophthalmic The metabolism of Doxepin can be decreased when combined with Acyclovir.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Doxepin.
Esomeprazole Injection Esomeprazole Injection The metabolism of Doxepin can be decreased when combined with Esomeprazole.
Alpelisib Alpelisib The serum concentration of Doxepin can be decreased when it is combined with Alpelisib.
Brexanolone Injection Brexanolone Injection Brexanolone may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Solriamfetol Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Doxepin.
Triclabendazole Triclabendazole The metabolism of Doxepin can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The risk or severity of QTc prolongation can be increased when Doxepin is combined with Entrectinib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Doxepin.
Pitolisant Pitolisant The therapeutic efficacy of Pitolisant can be decreased when used in combination with Doxepin.
Fedratinib Fedratinib The metabolism of Fedratinib can be decreased when combined with Doxepin.
Lefamulin Lefamulin Lefamulin may increase the QTc-prolonging activities of Doxepin.
Phenytoin Injection Phenytoin Injection The metabolism of Doxepin can be decreased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Doxepin.
Voxelotor Voxelotor The metabolism of Voxelotor can be decreased when combined with Doxepin.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Doxepin.
Lumateperone Lumateperone Lumateperone may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Lasmiditan Lasmiditan The risk or severity of serotonin syndrome can be increased when Doxepin is combined with Lasmiditan.
Cenobamate Cenobamate The serum concentration of Doxepin can be decreased when it is combined with Cenobamate.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Doxepin.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Doxepin.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Doxepin.
Capmatinib Capmatinib The metabolism of Doxepin can be decreased when combined with Capmatinib.
Lemborexant Lemborexant Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Fenfluramine Fenfluramine The risk or severity of serotonin syndrome can be increased when Fenfluramine is combined with Doxepin.
Fostemsavir Fostemsavir The risk or severity of QTc prolongation can be increased when Doxepin is combined with Fostemsavir.
Octreotide Octreotide The risk or severity of QTc prolongation can be increased when Octreotide is combined with Doxepin.
Pralsetinib Pralsetinib The metabolism of Doxepin can be decreased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Doxepin can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Doxepin is combined with Naxitamab.
Relugolix Relugolix The risk or severity of QTc prolongation can be increased when Doxepin is combined with Relugolix.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine Viloxazine Viloxazine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Doxepin.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Doxepin which could result in a higher serum level.
Indomethacin Indomethacin The metabolism of Doxepin can be decreased when combined with Indomethacin.
Mefenamic Acid Mefenamic Acid Mefenamic acid may decrease the excretion rate of Doxepin which could result in a higher serum level.
Naproxen Naproxen The metabolism of Doxepin can be decreased when combined with Naproxen.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Doxepin which could result in a higher serum level.
Trazodone Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Doxepin.
Isotretinoin Isotretinoin Isotretinoin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Doxepin which could result in a higher serum level.
Hydroxyurea Hydroxyurea The metabolism of Doxepin can be decreased when combined with Hydroxyurea.
Floxuridine Floxuridine The metabolism of Doxepin can be decreased when combined with Floxuridine.
Phenobarbital Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Doxepin.
Metaxalone Metaxalone Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Methotrexate Injection Methotrexate Injection Methotrexate may decrease the excretion rate of Doxepin which could result in a higher serum level.
Levorphanol Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Doxepin.
Primidone Primidone The metabolism of Doxepin can be increased when combined with Primidone.
Methsuximide Methsuximide Methsuximide may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Diethylpropion Diethylpropion Diethylpropion may decrease the sedative and stimulatory activities of Doxepin.
Chlorpromazine Chlorpromazine Chlorpromazine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Diazepam Diazepam Diazepam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Oxazepam Oxazepam Oxazepam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Flurazepam Flurazepam Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Clorazepate Clorazepate Clorazepic acid may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Lorazepam Lorazepam Lorazepam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Phenoxybenzamine Phenoxybenzamine Phenoxybenzamine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Carmustine Carmustine The metabolism of Doxepin can be decreased when combined with Carmustine.
Amantadine Amantadine The risk or severity of serotonin syndrome can be increased when Amantadine is combined with Doxepin.
Codeine Codeine The risk or severity of adverse effects can be increased when Doxepin is combined with Codeine.
Meprobamate Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Doxepin.
Chlordiazepoxide Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Doxepin.
Bromocriptine Bromocriptine Bromocriptine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Metaproterenol Metaproterenol The risk or severity of hypertension can be increased when Doxepin is combined with Orciprenaline.
Tranylcypromine Tranylcypromine The metabolism of Doxepin can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine Phenelzine may increase the serotonergic activities of Doxepin.
Procarbazine Procarbazine Procarbazine may increase the serotonergic activities of Doxepin.
Ergoloid Mesylates Ergoloid Mesylates Ergoloid mesylate may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Tetracycline Tetracycline Tetracycline may decrease the excretion rate of Doxepin which could result in a higher serum level.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Prochlorperazine Prochlorperazine The serum concentration of Doxepin can be increased when it is combined with Prochlorperazine.
Thioridazine Thioridazine Thioridazine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Trifluoperazine Trifluoperazine Trifluoperazine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Dapsone Dapsone The metabolism of Doxepin can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The metabolism of Doxepin can be decreased when combined with Sulfadiazine.
Oxycodone Oxycodone The risk or severity of adverse effects can be increased when Doxepin is combined with Oxycodone.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Doxepin.
Oxybutynin Oxybutynin Doxepin may increase the central nervous system depressant (CNS depressant) activities of Oxybutynin.
Benztropine Benztropine Doxepin may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
Maprotiline Maprotiline Maprotiline may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Ibuprofen Ibuprofen Ibuprofen may decrease the excretion rate of Doxepin which could result in a higher serum level.
Trihexyphenidyl Trihexyphenidyl Doxepin may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine Orphenadrine Doxepin may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine Perphenazine The serum concentration of Doxepin can be increased when it is combined with Perphenazine.
Azathioprine Azathioprine The metabolism of Doxepin can be decreased when combined with Azathioprine.
Fluphenazine Fluphenazine The serum concentration of Doxepin can be increased when it is combined with Fluphenazine.
Phentermine Phentermine Phentermine may decrease the sedative and stimulatory activities of Doxepin.
Methylphenidate Methylphenidate The therapeutic efficacy of Methylphenidate can be decreased when used in combination with Doxepin.
Amoxapine Amoxapine Amoxapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Doxepin which could result in a higher serum level.
Doxorubicin Doxorubicin The metabolism of Doxepin can be decreased when combined with Doxorubicin.
Mechlorethamine Mechlorethamine The therapeutic efficacy of Doxepin can be decreased when used in combination with Mechlorethamine.
Pyridostigmine Pyridostigmine The therapeutic efficacy of Doxepin can be decreased when used in combination with Pyridostigmine.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Doxepin which could result in a higher serum level.
Carbamazepine Carbamazepine The metabolism of Doxepin can be increased when combined with Carbamazepine.
Molindone Molindone The risk or severity of adverse effects can be increased when Doxepin is combined with Molindone.
Methyldopa Methyldopa The therapeutic efficacy of Methyldopa can be decreased when used in combination with Doxepin.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Doxepin.
Prazosin Prazosin Prazosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Hydralazine Hydralazine Doxepin may decrease the excretion rate of Hydralazine which could result in a higher serum level.
Cimetidine Cimetidine The metabolism of Doxepin can be decreased when combined with Cimetidine.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Warfarin Warfarin The metabolism of Doxepin can be decreased when combined with Warfarin.
Clonazepam Clonazepam Clonazepam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Loperamide Loperamide The metabolism of Loperamide can be decreased when combined with Doxepin.
Promethazine Promethazine The serum concentration of Doxepin can be increased when it is combined with Promethazine.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the excretion rate of Doxepin which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Doxepin can be increased when combined with Griseofulvin.
Digoxin Digoxin Digoxin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Loxapine Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Doxepin.
Chloroquine Chloroquine The metabolism of Doxepin can be decreased when combined with Chloroquine.
Quinine Quinine The metabolism of Doxepin can be decreased when combined with Quinine.
Ethosuximide Ethosuximide Ethosuximide may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Triamterene Triamterene The metabolism of Doxepin can be decreased when combined with Triamterene.
Lactulose Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Doxepin.
Sulfinpyrazone Sulfinpyrazone The metabolism of Doxepin can be decreased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide Doxepin may increase the excretion rate of Chlorothiazide which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone Chlorthalidone Doxepin may increase the excretion rate of Chlorthalidone which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone Metolazone Doxepin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide Isosorbide may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy.
Clindamycin Injection Clindamycin Injection Doxepin may increase the neurotoxic activities of Clindamycin.
Secobarbital Secobarbital Secobarbital may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Desipramine Desipramine The metabolism of Desipramine can be decreased when combined with Doxepin.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Doxepin.
Imipramine Imipramine Imipramine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Probenecid Probenecid The metabolism of Doxepin can be decreased when combined with Probenecid.
Quinidine Quinidine Quinidine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Procainamide Procainamide The metabolism of Doxepin can be decreased when combined with Procainamide.
Isoniazid Isoniazid The metabolism of Doxepin can be decreased when combined with Isoniazid.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Doxepin which could result in a higher serum level.
Rifampin Rifampin The metabolism of Doxepin can be increased when combined with Rifampicin.
Disopyramide Disopyramide Doxepin may increase the central nervous system depressant (CNS depressant) activities of Disopyramide.
Valproic Acid Valproic Acid Valproic acid may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Tamoxifen Tamoxifen The metabolism of Doxepin can be decreased when combined with Tamoxifen.
Butabarbital Butabarbital Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Levothyroxine Levothyroxine The risk or severity of Cardiac Arrhythmia and CNS stimulation can be increased when Levothyroxine is combined with Doxepin.
Liothyronine Liothyronine The risk or severity of Cardiac Arrhythmia can be increased when Liothyronine is combined with Doxepin.
Methimazole Methimazole The risk or severity of Cardiac Arrhythmia can be increased when Methimazole is combined with Doxepin.
Propylthiouracil Propylthiouracil The risk or severity of Cardiac Arrhythmia can be increased when Propylthiouracil is combined with Doxepin.
Chlorpropamide Chlorpropamide Chlorpropamide may decrease the hypoglycemic activities of Doxepin.
Glucagon Injection Glucagon Injection Doxepin may increase the gastrointestinal motility reducing activities of Glucagon.
Tolbutamide Tolbutamide Tolbutamide may decrease the hypoglycemic activities of Doxepin.
Tolazamide Tolazamide Tolazamide may decrease the hypoglycemic activities of Doxepin.
Dextromethorphan Dextromethorphan Dextromethorphan may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Cyclobenzaprine Cyclobenzaprine The risk or severity of CNS depression can be increased when Cyclobenzaprine is combined with Doxepin.
Niacin Niacin The metabolism of Doxepin can be decreased when combined with Niacin.
Baclofen Baclofen The risk or severity of CNS depression and hypotonia can be increased when Baclofen is combined with Doxepin.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Cyproheptadine Cyproheptadine Cyproheptadine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Clemastine Clemastine Clemastine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Chlorpheniramine Chlorpheniramine Chlorpheniramine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Brompheniramine Brompheniramine Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Meclizine Meclizine Meclizine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Doxepin which could result in a higher serum level.
Methyclothiazide Methyclothiazide Doxepin may increase the excretion rate of Methyclothiazide which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide Hydrochlorothiazide Doxepin may decrease the excretion rate of Hydrochlorothiazide which could result in a higher serum level.
Dantrolene Dantrolene Dantrolene may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Chlorzoxazone Chlorzoxazone Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Doxepin.
Methocarbamol Methocarbamol Methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Doxepin which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Doxepin which could result in a higher serum level.
Disulfiram Disulfiram The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Doxepin.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Doxepin can be decreased when combined with Propranolol.
Minoxidil Minoxidil Doxepin may decrease the antihypertensive activities of Minoxidil.
Pseudoephedrine Pseudoephedrine Pseudoephedrine may decrease the sedative and stimulatory activities of Doxepin.
Nortriptyline Nortriptyline The serum concentration of Doxepin can be increased when it is combined with Nortriptyline.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Doxepin which could result in a higher serum level.
Phytonadione Phytonadione Phylloquinone may decrease the excretion rate of Doxepin which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Nadolol Nadolol The metabolism of Nadolol can be decreased when combined with Doxepin.
Butorphanol Injection Butorphanol Injection The risk or severity of adverse effects can be increased when Butorphanol is combined with Doxepin.
Nalbuphine Injection Nalbuphine Injection The risk or severity of adverse effects can be increased when Nalbuphine is combined with Doxepin.
Allopurinol Allopurinol Allopurinol may decrease the excretion rate of Doxepin which could result in a higher serum level.
Oxytocin Injection Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Doxepin.
Trimethobenzamide Trimethobenzamide Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Flavoxate Flavoxate Doxepin may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Papaverine Papaverine The risk or severity of QTc prolongation can be increased when Doxepin is combined with Papaverine.
Fluorouracil Injection Fluorouracil Injection The metabolism of Doxepin can be decreased when combined with Fluorouracil.
Colchicine Colchicine Doxepin may decrease the excretion rate of Colchicine which could result in a higher serum level.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Doxepin which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Doxepin which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Dacarbazine Dacarbazine The metabolism of Doxepin can be decreased when combined with Dacarbazine.
Acetazolamide Acetazolamide Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Doxepin which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection The risk or severity of Cardiac Arrhythmia can be increased when Salmon calcitonin is combined with Doxepin.
Ketoconazole Ketoconazole Doxepin can cause a decrease in the absorption of Ketoconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pyrantel Pyrantel Pyrantel may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Thiotepa Injection Thiotepa Injection The therapeutic efficacy of Doxepin can be decreased when used in combination with Thiotepa.
Vincristine Injection Vincristine Injection Vincristine may increase the neurotoxic activities of Doxepin.
Captopril Captopril Doxepin may decrease the antihypertensive activities of Captopril.
Dipyridamole Dipyridamole The risk or severity of hypotension, dyspepsia, and headache can be increased when Dipyridamole is combined with Doxepin.
Isoxsuprine Isoxsuprine The risk or severity of hypertension can be increased when Doxepin is combined with Isoxsuprine.
Vinblastine Vinblastine The metabolism of Doxepin can be decreased when combined with Vinblastine.
Ethacrynic Acid Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Doxepin which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Doxepin which could result in a higher serum level.
Metoprolol Metoprolol The metabolism of Doxepin can be decreased when combined with Metoprolol.
Hydroxyzine Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Doxepin.
Thiothixene Thiothixene The risk or severity of adverse effects can be increased when Doxepin is combined with Thiothixene.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Doxepin which could result in a higher serum level.
Salsalate Salsalate Doxepin may decrease the excretion rate of Salsalate which could result in a higher serum level.
Alprazolam Alprazolam Alprazolam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Temazepam Temazepam Temazepam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Triazolam Triazolam Triazolam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Dicyclomine Dicyclomine Doxepin may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine Hyoscyamine Doxepin may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline Propantheline Doxepin may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Trimethoprim Trimethoprim Trimethoprim may decrease the excretion rate of Doxepin which could result in a higher serum level.
Diltiazem Diltiazem The metabolism of Doxepin can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Doxepin can be decreased when combined with Nifedipine.
Timolol Timolol The metabolism of Timolol can be decreased when combined with Doxepin.
Verapamil Verapamil Verapamil may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Atenolol Atenolol The metabolism of Atenolol can be decreased when combined with Doxepin.
Pindolol Pindolol Pindolol may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Cisplatin Injection Cisplatin Injection Cisplatin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Diflunisal Diflunisal Diflunisal may decrease the excretion rate of Doxepin which could result in a higher serum level.
Piroxicam Piroxicam Piroxicam may decrease the excretion rate of Doxepin which could result in a higher serum level.
Bumetanide Bumetanide Bumetanide may decrease the excretion rate of Doxepin which could result in a higher serum level.
Streptozocin Streptozocin The metabolism of Doxepin can be increased when combined with Streptozocin.
Etoposide Etoposide The metabolism of Doxepin can be decreased when combined with Etoposide.
Glyburide Glyburide The metabolism of Doxepin can be decreased when combined with Glyburide.
Glipizide Glipizide Glipizide may decrease the hypoglycemic activities of Doxepin.
Indapamide Indapamide Doxepin may increase the excretion rate of Indapamide which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin Amoxicillin Amoxicillin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Nafcillin Injection Nafcillin Injection The metabolism of Doxepin can be increased when combined with Nafcillin.
Oxacillin Injection Oxacillin Injection Oxacillin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Pentoxifylline Pentoxifylline The metabolism of Doxepin can be decreased when combined with Pentoxifylline.
Pentamidine Injection Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Doxepin.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Doxepin which could result in a higher serum level.
Labetalol Labetalol Labetalol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Auranofin Auranofin Auranofin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Doxepin.
Gemfibrozil Gemfibrozil The metabolism of Doxepin can be decreased when combined with Gemfibrozil.
Guanabenz Guanabenz The risk or severity of hypertension can be increased when Doxepin is combined with Guanabenz.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Doxepin which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Doxepin which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Doxepin which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Doxepin which could result in a higher serum level.
Pimozide Pimozide The metabolism of Doxepin can be decreased when combined with Pimozide.
Enalapril Enalapril Doxepin may decrease the antihypertensive activities of Enalapril.
Flurbiprofen Flurbiprofen Flurbiprofen may decrease the excretion rate of Doxepin which could result in a higher serum level.
Amiodarone Amiodarone The metabolism of Doxepin can be decreased when combined with Amiodarone.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Doxepin which could result in a higher serum level.
Buspirone Buspirone The metabolism of Buspirone can be decreased when combined with Doxepin.
Lovastatin Lovastatin The metabolism of Doxepin can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Doxepin can be decreased when combined with Ciprofloxacin.
Mesalamine Mesalamine The therapeutic efficacy of Mesalazine can be decreased when used in combination with Doxepin.
Diclofenac Diclofenac The metabolism of Doxepin can be decreased when combined with Diclofenac.
Fluoxetine Fluoxetine The serum concentration of Doxepin can be increased when it is combined with Fluoxetine.
Nimodipine Nimodipine The risk or severity of QTc prolongation can be increased when Doxepin is combined with Nimodipine.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The metabolism of Doxepin can be decreased when combined with Interferon alfa-2b.
Clozapine Clozapine Clozapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Estazolam Estazolam Estazolam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Doxepin.
Ofloxacin Ofloxacin The metabolism of Doxepin can be decreased when combined with Ofloxacin.
Didanosine Didanosine Didanosine may decrease the excretion rate of Doxepin which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Pentostatin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Clarithromycin Clarithromycin The risk or severity of QTc prolongation can be increased when Doxepin is combined with Clarithromycin.
Benazepril Benazepril Doxepin may decrease the antihypertensive activities of Benazepril.
Etodolac Etodolac Etodolac may decrease the excretion rate of Doxepin which could result in a higher serum level.
Felodipine Felodipine The metabolism of Doxepin can be decreased when combined with Felodipine.
Fosinopril Fosinopril Doxepin may decrease the excretion rate of Fosinopril which could result in a higher serum level.
Nabumetone Nabumetone The metabolism of Doxepin can be decreased when combined with Nabumetone.
Quinapril Quinapril Doxepin may decrease the antihypertensive activities of Quinapril.
Ramipril Ramipril Doxepin may decrease the antihypertensive activities of Ramipril.
Simvastatin Simvastatin The metabolism of Doxepin can be decreased when combined with Simvastatin.
Amlodipine Amlodipine The risk or severity of hypotension can be increased when Amlodipine is combined with Doxepin.
Teniposide Injection Teniposide Injection The metabolism of Doxepin can be decreased when combined with Teniposide.
Itraconazole Itraconazole Doxepin can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lisinopril Lisinopril Doxepin may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Atovaquone Atovaquone The metabolism of Doxepin can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Doxepin can be increased when combined with Rifabutin.
Sotalol Sotalol The metabolism of Doxepin can be decreased when combined with Sotalol.
Bisoprolol Bisoprolol Doxepin may increase the orthostatic hypotensive activities of Bisoprolol.
Zolpidem Zolpidem Doxepin may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin Doxazosin Doxazosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Terazosin Terazosin Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Terazosin.
Isradipine Isradipine The risk or severity of QTc prolongation can be increased when Doxepin is combined with Isradipine.
Omeprazole Omeprazole The metabolism of Doxepin can be increased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Doxepin can be decreased when combined with Cisapride.
Gabapentin Gabapentin The risk or severity of adverse effects can be increased when Gabapentin is combined with Doxepin.
Fluvastatin Fluvastatin The metabolism of Doxepin can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The metabolism of Doxepin can be decreased when combined with Venlafaxine.
Nizatidine Nizatidine The therapeutic efficacy of Doxepin can be decreased when used in combination with Nizatidine.
Stavudine Stavudine Stavudine may increase the neurotoxic activities of Doxepin.
Fluvoxamine Fluvoxamine The metabolism of Doxepin can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Nefazodone.
Lamotrigine Lamotrigine Lamotrigine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Losartan Losartan The metabolism of Doxepin can be decreased when combined with Losartan.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Doxepin which could result in a higher serum level.
Tramadol Tramadol The risk or severity of serotonin syndrome can be increased when Doxepin is combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The metabolism of Doxepin can be decreased when combined with Vinorelbine.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Moexipril Moexipril The risk or severity of QTc prolongation can be increased when Moexipril is combined with Doxepin.
Lansoprazole Lansoprazole The metabolism of Doxepin can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection Doxepin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Nicardipine Nicardipine Nicardipine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Bupropion Bupropion The risk or severity of seizure can be increased when Doxepin is combined with Bupropion.
Ticlopidine Ticlopidine The metabolism of Doxepin can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir Doxepin can cause an increase in the absorption of Saquinavir resulting in an increased serum concentration and potentially a worsening of adverse effects.
Metformin Metformin Doxepin may decrease the hypoglycemic activities of Metformin.
Nisoldipine Nisoldipine The risk or severity of hypotension can be increased when Doxepin is combined with Nisoldipine.
Lamivudine Lamivudine Lamivudine may decrease the excretion rate of Doxepin which could result in a higher serum level.
Riluzole Riluzole Riluzole may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Acarbose Acarbose Doxepin may decrease the hypoglycemic activities of Acarbose.
Glimepiride Glimepiride Glimepiride may decrease the hypoglycemic activities of Doxepin.
Gemcitabine Injection Gemcitabine Injection Gemcitabine may decrease the excretion rate of Doxepin which could result in a higher serum level.
Indinavir Indinavir Doxepin can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ritonavir Ritonavir The serum concentration of Doxepin can be increased when it is combined with Ritonavir.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Doxepin which could result in a higher serum level.
Meropenem Injection Meropenem Injection Meropenem may decrease the excretion rate of Doxepin which could result in a higher serum level.
Clomipramine Clomipramine The metabolism of Doxepin can be decreased when combined with Clomipramine.
Zafirlukast Zafirlukast The metabolism of Doxepin can be decreased when combined with Zafirlukast.
Fosfomycin Fosfomycin Fosfomycin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Mirtazapine Mirtazapine Doxepin may increase the serotonergic activities of Mirtazapine.
Trandolapril Trandolapril Doxepin may decrease the antihypertensive activities of Trandolapril.
Topiramate Topiramate The risk or severity of hyperthermia and oligohydrosis can be increased when Doxepin is combined with Topiramate.
Zileuton Zileuton The metabolism of Doxepin can be decreased when combined with Zileuton.
Valsartan Valsartan The metabolism of Doxepin can be decreased when combined with Valsartan.
Insulin Lispro Injection Insulin Lispro Injection The metabolism of Doxepin can be increased when combined with Insulin lispro.
Pramipexole Pramipexole Doxepin may increase the sedative activities of Pramipexole.
Donepezil Donepezil The therapeutic efficacy of Doxepin can be decreased when used in combination with Donepezil.
Nelfinavir Nelfinavir Doxepin can cause a decrease in the absorption of Nelfinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Azithromycin Azithromycin The risk or severity of QTc prolongation can be increased when Doxepin is combined with Azithromycin.
Loratadine Loratadine Doxepin may increase the anticholinergic activities of Loratadine.
Carvedilol Carvedilol Carvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Nilutamide Nilutamide The metabolism of Doxepin can be decreased when combined with Nilutamide.
Flutamide Flutamide The metabolism of Doxepin can be decreased when combined with Flutamide.
Selegiline Selegiline Selegiline may increase the serotonergic activities of Doxepin.
Bicalutamide Bicalutamide The metabolism of Doxepin can be decreased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Doxepin can be decreased when combined with Sertraline.
Propafenone Propafenone The metabolism of Doxepin can be decreased when combined with Propafenone.
Letrozole Letrozole The metabolism of Doxepin can be decreased when combined with Letrozole.
Irbesartan Irbesartan The metabolism of Doxepin can be decreased when combined with Irbesartan.
Tamsulosin Tamsulosin Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Tamsulosin.
Ropinirole Ropinirole Doxepin may increase the sedative activities of Ropinirole.
Finasteride Finasteride The risk or severity of hypertension can be increased when Doxepin is combined with Finasteride.
Quetiapine Quetiapine Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Quetiapine.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Doxepin which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Doxepin which could result in a higher serum level.
Cefpodoxime Cefpodoxime Doxepin can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cetirizine Cetirizine Cetirizine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Paroxetine Paroxetine The metabolism of Doxepin can be decreased when combined with Paroxetine.
Tolcapone Tolcapone The metabolism of Doxepin can be decreased when combined with Tolcapone.
Citalopram Citalopram The risk or severity of adverse effects can be increased when Doxepin is combined with Citalopram.
Capecitabine Capecitabine The metabolism of Doxepin can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Doxepin can be decreased when combined with Efavirenz.
Abacavir Abacavir Abacavir may decrease the excretion rate of Doxepin which could result in a higher serum level.
Sildenafil Sildenafil The metabolism of Doxepin can be decreased when combined with Sildenafil.
Pioglitazone Pioglitazone Doxepin may decrease the hypoglycemic activities of Pioglitazone.
Celecoxib Celecoxib The metabolism of Doxepin can be decreased when combined with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Doxepin can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine Tolterodine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Thalidomide Thalidomide Doxepin may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Doxepin which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may decrease the excretion rate of Doxepin which could result in a higher serum level.
Nateglinide Nateglinide The metabolism of Doxepin can be decreased when combined with Nateglinide.
Galantamine Galantamine The risk or severity of QTc prolongation can be increased when Doxepin is combined with Galantamine.
Levetiracetam Levetiracetam Levetiracetam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Rabeprazole Rabeprazole The metabolism of Doxepin can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Doxepin can be decreased when combined with Terbinafine.

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