Doxepin (Insomnia)
Generic name: Pronounced as (dox' e pin)
Medical Content Reviewed By HelloPharmacist Staff
Last Revised - 05/24/2017
On this page
- Why is this medication prescribed?
- How should this medicine be used?
- Other uses for this medicine
- What special precautions should I follow?
- What special dietary instructions should I follow?
- What should I do if I forget a dose?
- What side effects can this medication cause?
- What should I know about STORAGE and DISPOSAL of this medication?
- What should I do in case of OVERDOSE?
- What OTHER INFORMATION should I know?
- Drug interactions
Why is this medication prescribed?
Doxepin (Silenor) is used to treat insomnia (difficulty falling asleep or staying asleep) in people who have trouble staying asleep. Doxepin (Silenor) is in a class of medications called tricyclic antidepressants. It works by slowing activity in the brain to allow sleep.
Doxepin is also available as a capsule and liquid to treat depression and anxiety. This monograph only gives information about doxepin (Silenor) for insomnia. If you are using this medication for depression or anxiety, read the monograph entitled doxepin (depression, anxiety).
How should this medicine be used?
Doxepin (Silenor) comes as a tablet to take by mouth. It is usually taken once a day, within 30 minutes of bedtime. Do not take doxepin (Silenor) within 3 hours of a meal. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take doxepin (Silenor) exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
You will probably become very sleepy soon after you take doxepin (Silenor) and will remain sleepy for some time after you take the medication. Plan to go to bed right after you take doxepin (Silenor) and to stay in bed for 7 to 8 hours. Do not take doxepin (Silenor) if you will be unable to go to bed right away and remain asleep for 7 to 8 hours after taking the medication.
You should begin to sleep better during the first few days of treatment with doxepin (Silenor). If your sleep does not improve within 7-10 days, or gets worse call your doctor.
Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with doxepin (Silenor) and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking doxepin (Silenor),
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tell your doctor and pharmacist if you are allergic to doxepin (Silenor), amoxapine, loxapine, any other medications, or any of the ingredients in doxepin (Silenor) tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
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tell your doctor if you are taking a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking an MAO inhibitor within the past 14 days. Also tell your doctor if you are taking or receiving methylene blue (Provayblue) or linezolid (Zyvox). Your doctor will probably tell you not to take doxepin. If you stop taking doxepin, you should wait at least 14 days before you start to take an MAO inhibitor.
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tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: cimetidine (Tagamet); medications for cough, cold, or allergies; quinidine (in Nuedexta); sedatives; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); other sleeping pills; tolazamide; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with doxepin (Silenor), so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
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tell your doctor if you have or have ever had glaucoma that is not being treated, or urinary retention (inability to empty your bladder completely or at all). Your doctor may tell you not to take doxepin (Silenor).
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tell your doctor if you have or have ever drunk large amounts of alcohol, used street drugs, or over-used prescription medications. Also tell your doctor if you have or have ever had depression, mental illness, suicidal thoughts, sleep apnea (a sleep disorder that causes breathing to stop for short periods during sleep), or kidney or liver disease.
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tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking doxepin (Silenor), call your doctor.
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you should know that doxepin (Silenor) may make you drowsy. Do not drive a car, operate machinery, or do other dangerous activities at night after taking doxepin (Silenor). Do not drive a car or operate machinery the next day until you know how this medication affects you.
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you should know that alcohol can add to the drowsiness caused by this medication. Do not drink alcohol while you are taking doxepin (Silenor).
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you should know that some people who took doxepin (Silenor) got out of bed and drove their cars, prepared and ate food, had sex, made phone calls, were sleep-walking, or were involved in other activities while not fully awake. After they woke up, these people were usually unable to remember what they had done. Call your doctor right away if you find out that you have been driving or doing anything else unusual while you were sleeping.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose?
Doxepin (Silenor) should only be taken at bedtime. If you did not take doxepin (Silenor) before you went to bed and you are having trouble sleeping, you may take doxepin (Silenor) if you will be able to stay in bed for at least 7 to 8 hours afterward. Do not take a double dose of doxepin (Silenor) to make up for a missed dose.
What side effects can this medication cause?
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Doxepin (Silenor) may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
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nausea
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dizziness
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Doxepin (Silenor) may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
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If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, and excess heat and moisture (not in the bathroom).
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Symptoms of overdose may include:
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irregular heart beat
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feeling agitated, confused, or drowsy
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trouble concentrating
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seizures
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muscle stiffness
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vomiting
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increase in pupil size
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hallucination (seeing things or hearing voices that do not exist)
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fever
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cold body temperature
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coma (loss of consciousness for a period of time)
What OTHER INFORMATION should I know?
Keep all appointments with your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Drug interactions
Drug | Interaction |
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Moxifloxacin | Moxifloxacin The metabolism of Doxepin can be decreased when combined with Moxifloxacin. |
Repaglinide | Repaglinide Doxepin may decrease the hypoglycemic activities of Repaglinide. |
Montelukast | Montelukast The metabolism of Doxepin can be decreased when combined with Montelukast. |
Insulin Glargine (rDNA origin) Injection | Insulin Glargine (rDNA origin) Injection The metabolism of Doxepin can be increased when combined with Insulin glargine. |
Leflunomide | Leflunomide The serum concentration of Doxepin can be decreased when it is combined with Leflunomide. |
Delavirdine | Delavirdine Doxepin can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Nevirapine | Nevirapine The metabolism of Doxepin can be decreased when combined with Nevirapine. |
Dolasetron | Dolasetron Dolasetron may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Aminophylline | Aminophylline The metabolism of Aminophylline can be decreased when combined with Doxepin. |
Anagrelide | Anagrelide The metabolism of Doxepin can be decreased when combined with Anagrelide. |
Bisacodyl | Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Doxepin. |
Candesartan | Candesartan The metabolism of Doxepin can be decreased when combined with Candesartan. |
Cilostazol | Cilostazol The metabolism of Cilostazol can be decreased when combined with Doxepin. |
Clopidogrel | Clopidogrel The metabolism of Doxepin can be decreased when combined with Clopidogrel. |
Diphenoxylate | Diphenoxylate The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Doxepin. |
Erythromycin and Sulfisoxazole | Erythromycin and Sulfisoxazole The risk or severity of QTc prolongation can be increased when Doxepin is combined with Erythromycin. |
Estrogen and Progestin (Oral Contraceptives) | Estrogen and Progestin (Oral Contraceptives) The metabolism of Doxepin can be decreased when combined with Conjugated estrogens. |
Fenofibrate | Fenofibrate The metabolism of Doxepin can be decreased when combined with Fenofibrate. |
Guanfacine | Guanfacine Guanfacine may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Magnesium Hydroxide | Magnesium Hydroxide Doxepin may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level. |
Magnesium Oxide | Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Doxepin. |
Methylergonovine | Methylergonovine The risk or severity of hypertension can be increased when Methylergometrine is combined with Doxepin. |
Miglitol | Miglitol Doxepin may decrease the hypoglycemic activities of Miglitol. |
Mycophenolate | Mycophenolate Mycophenolic acid may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Naratriptan | Naratriptan The risk or severity of adverse effects can be increased when Naratriptan is combined with Doxepin. |
Olsalazine | Olsalazine Doxepin may decrease the excretion rate of Olsalazine which could result in a higher serum level. |
Paregoric | Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Doxepin. |
Penbutolol | Penbutolol The metabolism of Acebutolol can be decreased when combined with Doxepin. |
Pentazocine | Pentazocine The risk or severity of adverse effects can be increased when Pentazocine is combined with Doxepin. |
Polyethylene glycol-electrolyte solution (PEG-ES) | Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Doxepin. |
Potassium | Potassium Potassium may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy. |
Prednisone | Prednisone Prednisone may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Psyllium | Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Doxepin. |
Ranitidine | Ranitidine The metabolism of Doxepin can be decreased when combined with Ranitidine. |
Reserpine | Reserpine Reserpine may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Rizatriptan | Rizatriptan Rizatriptan may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Sumatriptan | Sumatriptan Sumatriptan may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Tacrolimus | Tacrolimus Tacrolimus may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Tizanidine | Tizanidine Tizanidine may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Zolmitriptan | Zolmitriptan The metabolism of Doxepin can be decreased when combined with Zolmitriptan. |
Ampicillin Injection | Ampicillin Injection Ampicillin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Doxycycline Injection | Doxycycline Injection Doxycycline may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Famotidine Injection | Famotidine Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Doxepin. |
Fluconazole Injection | Fluconazole Injection The metabolism of Doxepin can be decreased when combined with Fluconazole. |
Foscarnet Injection | Foscarnet Injection Foscarnet may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Hydromorphone Injection | Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Doxepin. |
Interferon Beta-1b Injection | Interferon Beta-1b Injection The metabolism of Doxepin can be decreased when combined with Interferon beta-1b. |
Interferon Gamma-1b Injection | Interferon Gamma-1b Injection The metabolism of Doxepin can be decreased when combined with Interferon gamma-1b. |
Levofloxacin Injection | Levofloxacin Injection The metabolism of Doxepin can be decreased when combined with Levofloxacin. |
Meperidine Injection | Meperidine Injection The risk or severity of adverse effects can be increased when Meperidine is combined with Doxepin. |
Metoclopramide Injection | Metoclopramide Injection The risk or severity of sedation can be increased when Metoclopramide is combined with Doxepin. |
Metronidazole Injection | Metronidazole Injection The metabolism of Doxepin can be decreased when combined with Metronidazole. |
Morphine Injection | Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Doxepin. |
Pamidronate Injection | Pamidronate Injection Pamidronic acid may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Vancomycin Injection | Vancomycin Injection Doxepin may decrease the excretion rate of Vancomycin which could result in a higher serum level. |
Zidovudine Injection | Zidovudine Injection The metabolism of Doxepin can be decreased when combined with Zidovudine. |
Altretamine | Altretamine Amphetamine may decrease the sedative and stimulatory activities of Doxepin. |
Cefuroxime | Cefuroxime Doxepin can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Cyclosporine | Cyclosporine The metabolism of Doxepin can be decreased when combined with Cyclosporine. |
Ondansetron | Ondansetron Ondansetron may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Granisetron | Granisetron The risk or severity of QTc prolongation can be increased when Doxepin is combined with Granisetron. |
Torsemide | Torsemide The metabolism of Doxepin can be decreased when combined with Torasemide. |
Olanzapine | Olanzapine Olanzapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Alosetron | Alosetron Alosetron may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Dofetilide | Dofetilide The risk or severity of QTc prolongation can be increased when Doxepin is combined with Dofetilide. |
Entacapone | Entacapone Entacapone may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Eprosartan | Eprosartan Doxepin may decrease the antihypertensive activities of Eprosartan. |
Hydroxychloroquine | Hydroxychloroquine The metabolism of Doxepin can be decreased when combined with Hydroxychloroquine. |
Meloxicam | Meloxicam Meloxicam may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Oxcarbazepine | Oxcarbazepine Oxcarbazepine may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Pantoprazole | Pantoprazole The metabolism of Doxepin can be decreased when combined with Pantoprazole. |
Risedronate | Risedronate Doxepin can cause an increase in the absorption of Risedronic acid resulting in an increased serum concentration and potentially a worsening of adverse effects. |
Telmisartan | Telmisartan The metabolism of Doxepin can be decreased when combined with Telmisartan. |
Temozolomide | Temozolomide Temozolomide may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Zaleplon | Zaleplon Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Anakinra | Anakinra The metabolism of Doxepin can be increased when combined with Anakinra. |
Desloratadine | Desloratadine Desloratadine may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Linezolid | Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Doxepin. |
Rivastigmine | Rivastigmine The therapeutic efficacy of Doxepin can be decreased when used in combination with Rivastigmine. |
Trimipramine | Trimipramine Trimipramine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Etanercept Injection | Etanercept Injection The metabolism of Doxepin can be increased when combined with Etanercept. |
Glycopyrrolate | Glycopyrrolate The risk or severity of adverse effects can be increased when Doxepin is combined with Glycopyrronium. |
Modafinil | Modafinil The metabolism of Doxepin can be decreased when combined with Modafinil. |
Perindopril | Perindopril Doxepin may decrease the antihypertensive activities of Perindopril. |
Tenofovir | Tenofovir Tenofovir may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Choline Magnesium Trisalicylate | Choline Magnesium Trisalicylate Doxepin may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level. |
Dutasteride | Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Doxepin. |
Epinephrine Injection | Epinephrine Injection Epinephrine may increase the vasopressor activities of Doxepin. |
Eplerenone | Eplerenone Doxepin may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy. |
Escitalopram | Escitalopram The risk or severity of serotonin syndrome can be increased when Doxepin is combined with Escitalopram. |
Olmesartan | Olmesartan Doxepin may decrease the antihypertensive activities of Olmesartan. |
Zonisamide | Zonisamide Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Adalimumab Injection | Adalimumab Injection The metabolism of Doxepin can be increased when combined with Adalimumab. |
Aripiprazole | Aripiprazole Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole. |
Atomoxetine | Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Doxepin. |
Dexmethylphenidate | Dexmethylphenidate The serum concentration of Doxepin can be increased when it is combined with Dexmethylphenidate. |
Atazanavir | Atazanavir Doxepin can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Almotriptan | Almotriptan Almotriptan may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Eletriptan | Eletriptan Eletriptan may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Mefloquine | Mefloquine The risk or severity of QTc prolongation can be increased when Mefloquine is combined with Doxepin. |
Polyethylene Glycol 3350 | Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Doxepin. |
Rosuvastatin | Rosuvastatin The metabolism of Doxepin can be decreased when combined with Rosuvastatin. |
Vardenafil | Vardenafil The risk or severity of QTc prolongation can be increased when Vardenafil is combined with Doxepin. |
Alfuzosin | Alfuzosin Alfuzosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Aprepitant | Aprepitant The metabolism of Doxepin can be decreased when combined with Aprepitant. |
Emtricitabine | Emtricitabine Emtricitabine may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Interferon Beta-1a Subcutaneous Injection | Interferon Beta-1a Subcutaneous Injection The metabolism of Doxepin can be decreased when combined with Interferon beta-1a. |
Memantine | Memantine The metabolism of Doxepin can be decreased when combined with Memantine. |
Tegaserod | Tegaserod The metabolism of Doxepin can be decreased when combined with Tegaserod. |
Tadalafil | Tadalafil The risk or severity of hypotension, dyspepsia, and headache can be increased when Doxepin is combined with Tadalafil. |
Fosamprenavir | Fosamprenavir Doxepin can cause a decrease in the absorption of Fosamprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Frovatriptan | Frovatriptan The metabolism of Doxepin can be decreased when combined with Frovatriptan. |
Gemifloxacin | Gemifloxacin The metabolism of Doxepin can be decreased when combined with Gemifloxacin. |
Progesterone | Progesterone The metabolism of Doxepin can be decreased when combined with Progesterone. |
Apomorphine Injection | Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Doxepin. |
Infliximab Injection | Infliximab Injection The metabolism of Doxepin can be increased when combined with Infliximab. |
Oxandrolone | Oxandrolone The metabolism of Doxepin can be decreased when combined with Oxandrolone. |
Protriptyline | Protriptyline Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Rifaximin | Rifaximin The metabolism of Doxepin can be increased when combined with Rifaximin. |
Duloxetine | Duloxetine The metabolism of Doxepin can be decreased when combined with Duloxetine. |
Tinidazole | Tinidazole Tinidazole may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Trospium | Trospium Doxepin may increase the central nervous system depressant (CNS depressant) activities of Trospium. |
Bosentan | Bosentan The metabolism of Doxepin can be increased when combined with Bosentan. |
Cefditoren | Cefditoren Cefdinir may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Cinacalcet | Cinacalcet The metabolism of Doxepin can be decreased when combined with Cinacalcet. |
Cyanocobalamin Injection | Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Erlotinib | Erlotinib Doxepin can cause a decrease in the absorption of Erlotinib resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Eszopiclone | Eszopiclone The risk or severity of CNS depression can be increased when Doxepin is combined with Eszopiclone. |
Ganciclovir | Ganciclovir Ganciclovir may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Insulin Aspart (rDNA Origin) Injection | Insulin Aspart (rDNA Origin) Injection Doxepin may decrease the hypoglycemic activities of Insulin aspart. |
Ribavirin | Ribavirin Ribavirin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Solifenacin | Solifenacin Doxepin may increase the central nervous system depressant (CNS depressant) activities of Solifenacin. |
Valganciclovir | Valganciclovir Doxepin may decrease the excretion rate of Valganciclovir which could result in a higher serum level. |
Voriconazole | Voriconazole The metabolism of Doxepin can be decreased when combined with Voriconazole. |
Adefovir | Adefovir Adefovir may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Dextroamphetamine | Dextroamphetamine Amphetamine may decrease the sedative and stimulatory activities of Doxepin. |
Entecavir | Entecavir The metabolism of Doxepin can be decreased when combined with Entecavir. |
Peginterferon Alfa-2a Injection | Peginterferon Alfa-2a Injection The metabolism of Doxepin can be decreased when combined with Peginterferon alfa-2a. |
Peginterferon Alfa-2b (PEG-Intron) | Peginterferon Alfa-2b (PEG-Intron) The serum concentration of Doxepin can be increased when it is combined with Peginterferon alfa-2b. |
Pramlintide Injection | Pramlintide Injection The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Doxepin. |
Sodium Oxybate | Sodium Oxybate Doxepin may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate. |
Exenatide Injection | Exenatide Injection Doxepin may decrease the hypoglycemic activities of Exenatide. |
Ibandronate | Ibandronate The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Doxepin. |
Isocarboxazid | Isocarboxazid Doxepin may increase the serotonergic activities of Isocarboxazid. |
Ramelteon | Ramelteon Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Darifenacin | Darifenacin The metabolism of Doxepin can be decreased when combined with Darifenacin. |
Fentanyl | Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Doxepin. |
Pregabalin | Pregabalin The therapeutic efficacy of Doxepin can be increased when used in combination with Pregabalin. |
Deferasirox | Deferasirox The serum concentration of Doxepin can be increased when it is combined with Deferasirox. |
Phenylephrine | Phenylephrine Doxepin may increase the vasopressor activities of Phenylephrine. |
Tipranavir | Tipranavir The metabolism of Doxepin can be decreased when combined with Tipranavir. |
Felbamate | Felbamate The metabolism of Doxepin can be decreased when combined with Felbamate. |
Insulin Detemir (rDNA Origin) Injection | Insulin Detemir (rDNA Origin) Injection Doxepin may decrease the hypoglycemic activities of Insulin detemir. |
Ranolazine | Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Doxepin. |
Abatacept Injection | Abatacept Injection The metabolism of Doxepin can be increased when combined with Abatacept. |
Rasagiline | Rasagiline Rasagiline may increase the serotonergic activities of Doxepin. |
Imatinib | Imatinib The metabolism of Doxepin can be decreased when combined with Imatinib. |
Sitagliptin | Sitagliptin Doxepin may decrease the hypoglycemic activities of Sitagliptin. |
Varenicline | Varenicline Doxepin may decrease the excretion rate of Varenicline which could result in a higher serum level. |
Gefitinib | Gefitinib Doxepin can cause a decrease in the absorption of Gefitinib resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Albuterol | Albuterol The risk or severity of QTc prolongation can be increased when Salbutamol is combined with Doxepin. |
Paliperidone | Paliperidone Paliperidone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Bortezomib | Bortezomib The risk or severity of QTc prolongation can be increased when Bortezomib is combined with Doxepin. |
Clofarabine Injection | Clofarabine Injection Clofarabine may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Insulin Glulisine (rDNA origin) Injection | Insulin Glulisine (rDNA origin) Injection The metabolism of Doxepin can be increased when combined with Insulin glulisine. |
Lubiprostone | Lubiprostone Doxepin may decrease the excretion rate of Lubiprostone which could result in a higher serum level. |
Oxaliplatin Injection | Oxaliplatin Injection The risk or severity of QTc prolongation can be increased when Doxepin is combined with Oxaliplatin. |
Posaconazole | Posaconazole The risk or severity of QTc prolongation can be increased when Doxepin is combined with Posaconazole. |
Primaquine | Primaquine The metabolism of Doxepin can be decreased when combined with Primaquine. |
Aliskiren | Aliskiren Doxepin may decrease the antihypertensive activities of Aliskiren. |
Bismuth Subsalicylate | Bismuth Subsalicylate Doxepin may increase the neurotoxic activities of Bismuth subsalicylate. |
Pemetrexed Injection | Pemetrexed Injection Pemetrexed may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Dimenhydrinate | Dimenhydrinate Dimenhydrinate may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Lisdexamfetamine | Lisdexamfetamine Lisdexamfetamine may decrease the sedative and stimulatory activities of Doxepin. |
Nabilone | Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Vorinostat | Vorinostat The risk or severity of QTc prolongation can be increased when Doxepin is combined with Vorinostat. |
Sorafenib | Sorafenib The metabolism of Doxepin can be decreased when combined with Sorafenib. |
Sunitinib | Sunitinib Doxepin may decrease the hypoglycemic activities of Sunitinib. |
Dronabinol | Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Lapatinib | Lapatinib The risk or severity of QTc prolongation can be increased when Doxepin is combined with Lapatinib. |
Levocetirizine | Levocetirizine Levocetirizine may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Pegaptanib Injection | Pegaptanib Injection Doxepin may decrease the excretion rate of Pegaptanib which could result in a higher serum level. |
Dasatinib | Dasatinib Doxepin can cause a decrease in the absorption of Dasatinib resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Mexiletine | Mexiletine The metabolism of Doxepin can be decreased when combined with Mexiletine. |
Armodafinil | Armodafinil The metabolism of Doxepin can be decreased when combined with Armodafinil. |
Azacitidine Injection | Azacitidine Injection Azacitidine may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Paclitaxel (with polyoxyethylated castor oil) Injection | Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Doxepin. |
Temsirolimus | Temsirolimus The metabolism of Doxepin can be decreased when combined with Temsirolimus. |
Lenalidomide | Lenalidomide Lenalidomide may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Nilotinib | Nilotinib Doxepin can cause a decrease in the absorption of Nilotinib resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Toremifene | Toremifene The risk or severity of QTc prolongation can be increased when Doxepin is combined with Toremifene. |
Bexarotene | Bexarotene The metabolism of Doxepin can be decreased when combined with Bexarotene. |
Budesonide | Budesonide Budesonide can cause a decrease in the absorption of Doxepin resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Chloramphenicol Injection | Chloramphenicol Injection The metabolism of Doxepin can be decreased when combined with Chloramphenicol. |
Desmopressin | Desmopressin The risk or severity of hyponatremia and water intoxication can be increased when Doxepin is combined with Desmopressin. |
Betaine | Betaine The therapeutic efficacy of Doxepin can be decreased when used in combination with Glycine betaine. |
OnabotulinumtoxinA Injection | OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Doxepin is combined with Botulinum toxin type A. |
RimabotulinumtoxinB Injection | RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Doxepin is combined with Botulinum Toxin Type B. |
Doripenem Injection | Doripenem Injection Doxepin may decrease the excretion rate of Doripenem which could result in a higher serum level. |
Etravirine | Etravirine The metabolism of Doxepin can be decreased when combined with Etravirine. |
Arsenic Trioxide Injection | Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Doxepin is combined with Arsenic trioxide. |
Desvenlafaxine | Desvenlafaxine The risk or severity of adverse effects can be increased when Doxepin is combined with Desvenlafaxine. |
Cevimeline | Cevimeline The metabolism of Cevimeline can be decreased when combined with Doxepin. |
Nebivolol | Nebivolol The metabolism of Nebivolol can be decreased when combined with Doxepin. |
Tretinoin | Tretinoin The metabolism of Doxepin can be decreased when combined with Tretinoin. |
Bendamustine Injection | Bendamustine Injection The metabolism of Bendamustine can be decreased when combined with Doxepin. |
Flecainide | Flecainide The metabolism of Flecainide can be decreased when combined with Doxepin. |
Certolizumab Injection | Certolizumab Injection The metabolism of Doxepin can be increased when combined with Certolizumab pegol. |
Daptomycin Injection | Daptomycin Injection Daptomycin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Praziquantel | Praziquantel The metabolism of Doxepin can be decreased when combined with Praziquantel. |
Methylnaltrexone Injection | Methylnaltrexone Injection Doxepin may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level. |
Rufinamide | Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Doxepin. |
Silodosin | Silodosin Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Silodosin. |
Midazolam | Midazolam Midazolam may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Naltrexone Injection | Naltrexone Injection The risk or severity of adverse effects can be increased when Naltrexone is combined with Doxepin. |
Dexrazoxane Injection | Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Eltrombopag | Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Doxepin. |
Milnacipran | Milnacipran The risk or severity of adverse effects can be increased when Doxepin is combined with Milnacipran. |
Dexlansoprazole | Dexlansoprazole The metabolism of Doxepin can be decreased when combined with Dexlansoprazole. |
Plerixafor Injection | Plerixafor Injection Doxepin may decrease the excretion rate of Plerixafor which could result in a higher serum level. |
Sodium Phosphate | Sodium Phosphate The risk or severity of seizure can be increased when Doxepin is combined with Sodium phosphate, monobasic. |
Fesoterodine | Fesoterodine Doxepin may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine. |
Degarelix Injection | Degarelix Injection The risk or severity of QTc prolongation can be increased when Doxepin is combined with Degarelix. |
Betaxolol | Betaxolol The metabolism of Doxepin can be decreased when combined with Betaxolol. |
Iloperidone | Iloperidone Iloperidone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Prasugrel | Prasugrel Doxepin may decrease the excretion rate of Prasugrel which could result in a higher serum level. |
Lacosamide | Lacosamide Doxepin may increase the central nervous system depressant (CNS depressant) activities of Lacosamide. |
Everolimus | Everolimus The metabolism of Doxepin can be decreased when combined with Everolimus. |
Tolvaptan (low blood sodium) | Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy. |
Dronedarone | Dronedarone Doxepin may increase the QTc-prolonging activities of Dronedarone. |
AbobotulinumtoxinA Injection | AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Doxepin is combined with Botulinum toxin type A. |
Pralatrexate Injection | Pralatrexate Injection Doxepin may decrease the excretion rate of Pralatrexate which could result in a higher serum level. |
Palonosetron Injection | Palonosetron Injection Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Saxagliptin | Saxagliptin Doxepin may decrease the hypoglycemic activities of Saxagliptin. |
Telavancin Injection | Telavancin Injection The risk or severity of QTc prolongation can be increased when Doxepin is combined with Telavancin. |
Romidepsin Injection | Romidepsin Injection The risk or severity of QTc prolongation can be increased when Doxepin is combined with Romidepsin. |
Tapentadol | Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Topotecan | Topotecan Topotecan may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Golimumab Injection | Golimumab Injection The metabolism of Doxepin can be increased when combined with Golimumab. |
Pazopanib | Pazopanib The therapeutic efficacy of Pazopanib can be decreased when used in combination with Doxepin. |
Asenapine | Asenapine Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Asenapine. |
Vigabatrin | Vigabatrin Vigabatrin may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Pitavastatin | Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Doxepin. |
Albendazole | Albendazole The metabolism of Doxepin can be decreased when combined with Albendazole. |
Oxymorphone | Oxymorphone The risk or severity of adverse effects can be increased when Doxepin is combined with Oxymorphone. |
Liraglutide Injection | Liraglutide Injection Doxepin may decrease the hypoglycemic activities of Liraglutide. |
Tocilizumab Injection | Tocilizumab Injection The metabolism of Doxepin can be increased when combined with Tocilizumab. |
Dalfampridine | Dalfampridine The risk or severity of seizure can be increased when Dalfampridine is combined with Doxepin. |
Eribulin Injection | Eribulin Injection The risk or severity of QTc prolongation can be increased when Doxepin is combined with Eribulin. |
IncobotulinumtoxinA Injection | IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Doxepin is combined with Botulinum toxin type A. |
Ceftaroline Injection | Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Lurasidone | Lurasidone Doxepin may increase the hypotensive activities of Lurasidone. |
Acetaminophen Injection | Acetaminophen Injection The metabolism of Doxepin can be decreased when combined with Acetaminophen. |
Vilazodone | Vilazodone The metabolism of Vilazodone can be decreased when combined with Doxepin. |
Ipilimumab Injection | Ipilimumab Injection Doxepin may decrease the excretion rate of Ipilimumab which could result in a higher serum level. |
Denileukin Diftitox Injection | Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Terbutaline Injection | Terbutaline Injection The therapeutic efficacy of Doxepin can be decreased when used in combination with Terbutaline. |
Roflumilast | Roflumilast Doxepin may decrease the excretion rate of Roflumilast which could result in a higher serum level. |
Linagliptin | Linagliptin Doxepin may decrease the hypoglycemic activities of Linagliptin. |
Rilpivirine | Rilpivirine Doxepin can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Potassium Iodide | Potassium Iodide The risk or severity of Cardiac Arrhythmia can be increased when Potassium Iodide is combined with Doxepin. |
Cyclophosphamide Injection | Cyclophosphamide Injection The metabolism of Doxepin can be decreased when combined with Cyclophosphamide. |
Abiraterone | Abiraterone The serum concentration of Doxepin can be increased when it is combined with Abiraterone. |
Triptorelin Injection | Triptorelin Injection The risk or severity of QTc prolongation can be increased when Doxepin is combined with Triptorelin. |
Rivaroxaban | Rivaroxaban Doxepin may decrease the excretion rate of Rivaroxaban which could result in a higher serum level. |
Ticagrelor | Ticagrelor The metabolism of Doxepin can be decreased when combined with Ticagrelor. |
Ruxolitinib | Ruxolitinib Doxepin may decrease the excretion rate of Ruxolitinib which could result in a higher serum level. |
Vandetanib | Vandetanib The risk or severity of QTc prolongation can be increased when Doxepin is combined with Vandetanib. |
Clobazam | Clobazam The metabolism of Doxepin can be decreased when combined with Clobazam. |
Vemurafenib | Vemurafenib The serum concentration of Doxepin can be increased when it is combined with Vemurafenib. |
Vismodegib | Vismodegib The metabolism of Doxepin can be decreased when combined with Vismodegib. |
Deferiprone | Deferiprone Doxepin may decrease the excretion rate of Deferiprone which could result in a higher serum level. |
Axitinib | Axitinib The metabolism of Axitinib can be decreased when combined with Doxepin. |
Crizotinib | Crizotinib The risk or severity of QTc prolongation can be increased when Doxepin is combined with Crizotinib. |
Cabergoline | Cabergoline Cabergoline may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Naloxone Injection | Naloxone Injection Doxepin may decrease the excretion rate of Naloxone which could result in a higher serum level. |
Ambrisentan | Ambrisentan Doxepin may decrease the antihypertensive activities of Ambrisentan. |
Fondaparinux Injection | Fondaparinux Injection Fondaparinux may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Ezogabine | Ezogabine Tiagabine may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Enzalutamide | Enzalutamide The metabolism of Doxepin can be increased when combined with Enzalutamide. |
Mirabegron | Mirabegron The risk or severity of urinary retention can be increased when Doxepin is combined with Mirabegron. |
Regorafenib | Regorafenib The metabolism of Doxepin can be decreased when combined with Regorafenib. |
Bosutinib | Bosutinib Doxepin can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Linaclotide | Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Doxepin. |
Teriflunomide | Teriflunomide The serum concentration of Doxepin can be decreased when it is combined with Teriflunomide. |
Lorcaserin | Lorcaserin Doxepin may decrease the hypoglycemic activities of Mecasermin. |
Cabozantinib (thyroid cancer) | Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Doxepin. |
Teduglutide Injection | Teduglutide Injection Doxepin may decrease the excretion rate of Teduglutide which could result in a higher serum level. |
Bedaquiline | Bedaquiline The risk or severity of QTc prolongation can be increased when Doxepin is combined with Bedaquiline. |
Alogliptin | Alogliptin The metabolism of Alogliptin can be decreased when combined with Doxepin. |
Ponatinib | Ponatinib The metabolism of Ponatinib can be decreased when combined with Doxepin. |
Pomalidomide | Pomalidomide Pomalidomide may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Apixaban | Apixaban The metabolism of Apixaban can be decreased when combined with Doxepin. |
Canagliflozin | Canagliflozin Doxepin may decrease the hypoglycemic activities of Canagliflozin. |
Methazolamide | Methazolamide Methazolamide may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy. |
Dabrafenib | Dabrafenib The serum concentration of Doxepin can be decreased when it is combined with Dabrafenib. |
Ospemifene | Ospemifene The metabolism of Ospemifene can be decreased when combined with Doxepin. |
Trametinib | Trametinib Doxepin may decrease the excretion rate of Trametinib which could result in a higher serum level. |
Levomilnacipran | Levomilnacipran The risk or severity of adverse effects can be increased when Doxepin is combined with Levomilnacipran. |
Ertapenem Injection | Ertapenem Injection Ertapenem may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Vortioxetine | Vortioxetine Doxepin may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine. |
Perampanel | Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Ibrutinib | Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Doxepin. |
Avanafil | Avanafil The risk or severity of hypotension, dyspepsia, and headache can be increased when Avanafil is combined with Doxepin. |
Ketorolac Injection | Ketorolac Injection Ketorolac may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Simeprevir | Simeprevir The metabolism of Doxepin can be decreased when combined with Simeprevir. |
Sofosbuvir | Sofosbuvir Doxepin may decrease the excretion rate of Sofosbuvir which could result in a higher serum level. |
Dapagliflozin | Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Doxepin. |
Iron Sucrose Injection | Iron Sucrose Injection Doxepin can cause a decrease in the absorption of Iron sucrose resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Apremilast | Apremilast The metabolism of Doxepin can be increased when combined with Apremilast. |
Droxidopa | Droxidopa Doxepin may increase the vasopressor activities of Droxidopa. |
Ceritinib | Ceritinib The metabolism of Doxepin can be decreased when combined with Ceritinib. |
Siltuximab Injection | Siltuximab Injection The metabolism of Doxepin can be increased when combined with Siltuximab. |
Albiglutide Injection | Albiglutide Injection Doxepin may decrease the hypoglycemic activities of Albiglutide. |
Eslicarbazepine | Eslicarbazepine Eslicarbazepine may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Belinostat Injection | Belinostat Injection The metabolism of Doxepin can be increased when combined with Belinostat. |
Testosterone Injection | Testosterone Injection The metabolism of Doxepin can be decreased when combined with Testosterone. |
Oritavancin Injection | Oritavancin Injection The metabolism of Doxepin can be decreased when combined with Oritavancin. |
Empagliflozin | Empagliflozin Doxepin may decrease the hypoglycemic activities of Empagliflozin. |
Hydrocodone | Hydrocodone Hydrocodone may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Suvorexant | Suvorexant Doxepin may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
Dulaglutide Injection | Dulaglutide Injection Doxepin may decrease the hypoglycemic activities of Dulaglutide. |
Edoxaban | Edoxaban Doxepin may decrease the excretion rate of Edoxaban which could result in a higher serum level. |
Peginterferon Beta-1a Injection | Peginterferon Beta-1a Injection The metabolism of Doxepin can be decreased when combined with Peginterferon beta-1a. |
Methamphetamine | Methamphetamine Metamfetamine may decrease the sedative and stimulatory activities of Doxepin. |
Tasimelteon | Tasimelteon Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Riociguat | Riociguat Doxepin may decrease the antihypertensive activities of Riociguat. |
Pirfenidone | Pirfenidone The metabolism of Pirfenidone can be decreased when combined with Doxepin. |
Secukinumab Injection | Secukinumab Injection The metabolism of Doxepin can be increased when combined with Secukinumab. |
Risperidone Injection | Risperidone Injection Risperidone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Insulin Human Inhalation | Insulin Human Inhalation The metabolism of Doxepin can be increased when combined with Insulin human. |
Lenvatinib | Lenvatinib The metabolism of Doxepin can be decreased when combined with Lenvatinib. |
Naloxegol | Naloxegol The metabolism of Doxepin can be decreased when combined with Naloxegol. |
Panobinostat | Panobinostat The metabolism of Doxepin can be decreased when combined with Panobinostat. |
Haloperidol Injection | Haloperidol Injection The serum concentration of Doxepin can be increased when it is combined with Haloperidol. |
Ivabradine | Ivabradine The risk or severity of QTc prolongation can be increased when Doxepin is combined with Ivabradine. |
Amiloride | Amiloride Amiloride may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy. |
Isavuconazonium Injection | Isavuconazonium Injection Doxepin can cause a decrease in the absorption of Isavuconazonium resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Macitentan | Macitentan Doxepin may decrease the excretion rate of Macitentan which could result in a higher serum level. |
Flibanserin | Flibanserin Flibanserin may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Rolapitant | Rolapitant The metabolism of Doxepin can be decreased when combined with Rolapitant. |
Brexpiprazole | Brexpiprazole Brexpiprazole may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Ziprasidone Injection | Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Ziprasidone is combined with Doxepin. |
Cariprazine | Cariprazine Cariprazine may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Penicillin G Procaine Injection | Penicillin G Procaine Injection Doxepin may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level. |
Eluxadoline | Eluxadoline The risk or severity of constipation can be increased when Doxepin is combined with Eluxadoline. |
Insulin Degludec (rDNA Origin) Injection | Insulin Degludec (rDNA Origin) Injection The metabolism of Doxepin can be increased when combined with Insulin degludec. |
Trabectedin Injection | Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Doxepin. |
Osimertinib | Osimertinib The serum concentration of Doxepin can be decreased when it is combined with Osimertinib. |
Ixazomib | Ixazomib Doxepin may decrease the excretion rate of Ixazomib which could result in a higher serum level. |
Rifapentine | Rifapentine The metabolism of Doxepin can be increased when combined with Rifapentine. |
Lesinurad | Lesinurad Doxepin may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
Amphotericin B Liposomal Injection | Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Brivaracetam Injection | Brivaracetam Injection Doxepin may increase the central nervous system depressant (CNS depressant) activities of Brivaracetam. |
Cobicistat | Cobicistat The metabolism of Doxepin can be decreased when combined with Cobicistat. |
Midodrine | Midodrine Midodrine may increase the vasopressor activities of Doxepin. |
Selexipag | Selexipag Doxepin may decrease the antihypertensive activities of Selexipag. |
Pimavanserin | Pimavanserin The risk or severity of adverse effects can be increased when Doxepin is combined with Pimavanserin. |
Obeticholic Acid | Obeticholic Acid The metabolism of Doxepin can be decreased when combined with Obeticholic acid. |
Diphenhydramine Injection | Diphenhydramine Injection Diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Furosemide Injection | Furosemide Injection Doxepin may decrease the excretion rate of Furosemide which could result in a higher serum level. |
Rucaparib | Rucaparib The metabolism of Doxepin can be decreased when combined with Rucaparib. |
Lixisenatide Injection | Lixisenatide Injection Doxepin may decrease the hypoglycemic activities of Lixisenatide. |
Ribociclib | Ribociclib The risk or severity of QTc prolongation can be increased when Doxepin is combined with Ribociclib. |
Plecanatide | Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Doxepin. |
Deutetrabenazine | Deutetrabenazine The risk or severity of sedation and somnolence can be increased when Doxepin is combined with Deutetrabenazine. |
Valbenazine | Valbenazine The metabolism of Valbenazine can be decreased when combined with Doxepin. |
Safinamide | Safinamide Safinamide may increase the serotonergic activities of Doxepin. |
Naldemedine | Naldemedine Doxepin may decrease the excretion rate of Naldemedine which could result in a higher serum level. |
Midostaurin | Midostaurin The metabolism of Doxepin can be decreased when combined with Midostaurin. |
Enasidenib | Enasidenib The metabolism of Doxepin can be decreased when combined with Enasidenib. |
Benznidazole | Benznidazole Doxepin may decrease the excretion rate of Benznidazole which could result in a higher serum level. |
Delafloxacin | Delafloxacin The risk or severity of QTc prolongation can be increased when Delafloxacin is combined with Doxepin. |
Letermovir | Letermovir The metabolism of Letermovir can be decreased when combined with Doxepin. |
Semaglutide Injection | Semaglutide Injection Doxepin may decrease the hypoglycemic activities of Semaglutide. |
Tetrabenazine | Tetrabenazine The risk or severity of sedation and somnolence can be increased when Doxepin is combined with Tetrabenazine. |
Ertugliflozin | Ertugliflozin Doxepin may decrease the hypoglycemic activities of Ertugliflozin. |
Buprenorphine Injection | Buprenorphine Injection Doxepin may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
Apalutamide | Apalutamide The serum concentration of Doxepin can be increased when it is combined with Apalutamide. |
Fostamatinib | Fostamatinib The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Doxepin. |
Avatrombopag | Avatrombopag The metabolism of Doxepin can be increased when combined with Avatrombopag. |
Baricitinib | Baricitinib Doxepin may decrease the excretion rate of Baricitinib which could result in a higher serum level. |
Lofexidine | Lofexidine The therapeutic efficacy of Doxepin can be increased when used in combination with Lofexidine. |
Plazomicin Injection | Plazomicin Injection Doxepin may decrease the excretion rate of Plazomicin which could result in a higher serum level. |
Eliglustat | Eliglustat The metabolism of Eliglustat can be decreased when combined with Doxepin. |
Encorafenib | Encorafenib The metabolism of Encorafenib can be decreased when combined with Doxepin. |
Binimetinib | Binimetinib The metabolism of Binimetinib can be decreased when combined with Doxepin. |
Ivosidenib | Ivosidenib The risk or severity of QTc prolongation can be increased when Doxepin is combined with Ivosidenib. |
Elagolix | Elagolix The metabolism of Elagolix can be decreased when combined with Doxepin. |
Tafenoquine | Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Doxepin. |
Cannabidiol | Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Doxepin. |
Dacomitinib | Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Doxepin. |
Stiripentol | Stiripentol The metabolism of Doxepin can be decreased when combined with Stiripentol. |
Gilteritinib | Gilteritinib The therapeutic efficacy of Doxepin can be decreased when used in combination with Gilteritinib. |
Glasdegib | Glasdegib The risk or severity of QTc prolongation can be increased when Doxepin is combined with Glasdegib. |
Lorlatinib | Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Doxepin. |
Paclitaxel (with albumin) Injection | Paclitaxel (with albumin) Injection Doxepin may increase the neurotoxic activities of Paclitaxel. |
Rifamycin | Rifamycin The metabolism of Doxepin can be increased when combined with Rifamycin. |
Prucalopride | Prucalopride Doxepin may decrease the excretion rate of Prucalopride which could result in a higher serum level. |
Magnesium Citrate | Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Doxepin. |
Emapalumab-lzsg Injection | Emapalumab-lzsg Injection The metabolism of Doxepin can be increased when combined with Emapalumab. |
Siponimod | Siponimod The metabolism of Siponimod can be decreased when combined with Doxepin. |
Acyclovir Ophthalmic | Acyclovir Ophthalmic The metabolism of Doxepin can be decreased when combined with Acyclovir. |
Erdafitinib | Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Doxepin. |
Esomeprazole Injection | Esomeprazole Injection The metabolism of Doxepin can be decreased when combined with Esomeprazole. |
Alpelisib | Alpelisib The serum concentration of Doxepin can be decreased when it is combined with Alpelisib. |
Brexanolone Injection | Brexanolone Injection Brexanolone may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Solriamfetol | Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Doxepin. |
Triclabendazole | Triclabendazole The metabolism of Doxepin can be decreased when combined with Triclabendazole. |
Entrectinib | Entrectinib The risk or severity of QTc prolongation can be increased when Doxepin is combined with Entrectinib. |
Istradefylline | Istradefylline The metabolism of Istradefylline can be decreased when combined with Doxepin. |
Pitolisant | Pitolisant The therapeutic efficacy of Pitolisant can be decreased when used in combination with Doxepin. |
Fedratinib | Fedratinib The metabolism of Fedratinib can be decreased when combined with Doxepin. |
Lefamulin | Lefamulin Lefamulin may increase the QTc-prolonging activities of Doxepin. |
Phenytoin Injection | Phenytoin Injection The metabolism of Doxepin can be decreased when combined with Phenytoin. |
Fosphenytoin Injection | Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Doxepin. |
Voxelotor | Voxelotor The metabolism of Voxelotor can be decreased when combined with Doxepin. |
Avapritinib | Avapritinib The metabolism of Avapritinib can be decreased when combined with Doxepin. |
Lumateperone | Lumateperone Lumateperone may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Lasmiditan | Lasmiditan The risk or severity of serotonin syndrome can be increased when Doxepin is combined with Lasmiditan. |
Cenobamate | Cenobamate The serum concentration of Doxepin can be decreased when it is combined with Cenobamate. |
Selumetinib | Selumetinib The metabolism of Selumetinib can be decreased when combined with Doxepin. |
Tucatinib | Tucatinib The metabolism of Tucatinib can be decreased when combined with Doxepin. |
Selpercatinib | Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Doxepin. |
Capmatinib | Capmatinib The metabolism of Doxepin can be decreased when combined with Capmatinib. |
Lemborexant | Lemborexant Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Fenfluramine | Fenfluramine The risk or severity of serotonin syndrome can be increased when Fenfluramine is combined with Doxepin. |
Fostemsavir | Fostemsavir The risk or severity of QTc prolongation can be increased when Doxepin is combined with Fostemsavir. |
Octreotide | Octreotide The risk or severity of QTc prolongation can be increased when Octreotide is combined with Doxepin. |
Pralsetinib | Pralsetinib The metabolism of Doxepin can be decreased when combined with Pralsetinib. |
Satralizumab-mwge Injection | Satralizumab-mwge Injection The serum concentration of Doxepin can be decreased when it is combined with Satralizumab. |
Naxitamab-gqgk Injection | Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Doxepin is combined with Naxitamab. |
Relugolix | Relugolix The risk or severity of QTc prolongation can be increased when Doxepin is combined with Relugolix. |
Progestin-Only (drospirenone) Oral Contraceptives | Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy. |
Viloxazine | Viloxazine Viloxazine may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Tobramycin Injection | Tobramycin Injection Tobramycin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Theophylline | Theophylline The metabolism of Theophylline can be decreased when combined with Doxepin. |
Fenoprofen | Fenoprofen Fenoprofen may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Indomethacin | Indomethacin The metabolism of Doxepin can be decreased when combined with Indomethacin. |
Mefenamic Acid | Mefenamic Acid Mefenamic acid may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Naproxen | Naproxen The metabolism of Doxepin can be decreased when combined with Naproxen. |
Tolmetin | Tolmetin Tolmetin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Sulindac | Sulindac Sulindac may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Trazodone | Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Doxepin. |
Isotretinoin | Isotretinoin Isotretinoin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Sucralfate | Sucralfate Sucralfate may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Hydroxyurea | Hydroxyurea The metabolism of Doxepin can be decreased when combined with Hydroxyurea. |
Floxuridine | Floxuridine The metabolism of Doxepin can be decreased when combined with Floxuridine. |
Phenobarbital | Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Doxepin. |
Metaxalone | Metaxalone Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Methotrexate Injection | Methotrexate Injection Methotrexate may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Levorphanol | Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Doxepin. |
Primidone | Primidone The metabolism of Doxepin can be increased when combined with Primidone. |
Methsuximide | Methsuximide Methsuximide may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Diethylpropion | Diethylpropion Diethylpropion may decrease the sedative and stimulatory activities of Doxepin. |
Chlorpromazine | Chlorpromazine Chlorpromazine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Diazepam | Diazepam Diazepam may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Oxazepam | Oxazepam Oxazepam may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Flurazepam | Flurazepam Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Clorazepate | Clorazepate Clorazepic acid may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Lorazepam | Lorazepam Lorazepam may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Phenoxybenzamine | Phenoxybenzamine Phenoxybenzamine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Carmustine | Carmustine The metabolism of Doxepin can be decreased when combined with Carmustine. |
Amantadine | Amantadine The risk or severity of serotonin syndrome can be increased when Amantadine is combined with Doxepin. |
Codeine | Codeine The risk or severity of adverse effects can be increased when Doxepin is combined with Codeine. |
Meprobamate | Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Doxepin. |
Chlordiazepoxide | Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Doxepin. |
Bromocriptine | Bromocriptine Bromocriptine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Metaproterenol | Metaproterenol The risk or severity of hypertension can be increased when Doxepin is combined with Orciprenaline. |
Tranylcypromine | Tranylcypromine The metabolism of Doxepin can be decreased when combined with Tranylcypromine. |
Phenelzine | Phenelzine Phenelzine may increase the serotonergic activities of Doxepin. |
Procarbazine | Procarbazine Procarbazine may increase the serotonergic activities of Doxepin. |
Ergoloid Mesylates | Ergoloid Mesylates Ergoloid mesylate may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Tetracycline | Tetracycline Tetracycline may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Minocycline | Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Prochlorperazine | Prochlorperazine The serum concentration of Doxepin can be increased when it is combined with Prochlorperazine. |
Thioridazine | Thioridazine Thioridazine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Trifluoperazine | Trifluoperazine Trifluoperazine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Bleomycin | Bleomycin Bleomycin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Dapsone | Dapsone The metabolism of Doxepin can be decreased when combined with Dapsone. |
Sulfadiazine | Sulfadiazine The metabolism of Doxepin can be decreased when combined with Sulfadiazine. |
Oxycodone | Oxycodone The risk or severity of adverse effects can be increased when Doxepin is combined with Oxycodone. |
Methadone | Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Doxepin. |
Oxybutynin | Oxybutynin Doxepin may increase the central nervous system depressant (CNS depressant) activities of Oxybutynin. |
Benztropine | Benztropine Doxepin may increase the central nervous system depressant (CNS depressant) activities of Benzatropine. |
Maprotiline | Maprotiline Maprotiline may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Ibuprofen | Ibuprofen Ibuprofen may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Trihexyphenidyl | Trihexyphenidyl Doxepin may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl. |
Orphenadrine | Orphenadrine Doxepin may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
Perphenazine | Perphenazine The serum concentration of Doxepin can be increased when it is combined with Perphenazine. |
Azathioprine | Azathioprine The metabolism of Doxepin can be decreased when combined with Azathioprine. |
Fluphenazine | Fluphenazine The serum concentration of Doxepin can be increased when it is combined with Fluphenazine. |
Phentermine | Phentermine Phentermine may decrease the sedative and stimulatory activities of Doxepin. |
Methylphenidate | Methylphenidate The therapeutic efficacy of Methylphenidate can be decreased when used in combination with Doxepin. |
Amoxapine | Amoxapine Amoxapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Sulfasalazine | Sulfasalazine Sulfasalazine may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Doxorubicin | Doxorubicin The metabolism of Doxepin can be decreased when combined with Doxorubicin. |
Mechlorethamine | Mechlorethamine The therapeutic efficacy of Doxepin can be decreased when used in combination with Mechlorethamine. |
Pyridostigmine | Pyridostigmine The therapeutic efficacy of Doxepin can be decreased when used in combination with Pyridostigmine. |
Phenazopyridine | Phenazopyridine Phenazopyridine may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Carbamazepine | Carbamazepine The metabolism of Doxepin can be increased when combined with Carbamazepine. |
Molindone | Molindone The risk or severity of adverse effects can be increased when Doxepin is combined with Molindone. |
Methyldopa | Methyldopa The therapeutic efficacy of Methyldopa can be decreased when used in combination with Doxepin. |
Clonidine | Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Doxepin. |
Prazosin | Prazosin Prazosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Hydralazine | Hydralazine Doxepin may decrease the excretion rate of Hydralazine which could result in a higher serum level. |
Cimetidine | Cimetidine The metabolism of Doxepin can be decreased when combined with Cimetidine. |
Gentamicin Injection | Gentamicin Injection Gentamicin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Warfarin | Warfarin The metabolism of Doxepin can be decreased when combined with Warfarin. |
Clonazepam | Clonazepam Clonazepam may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Loperamide | Loperamide The metabolism of Loperamide can be decreased when combined with Doxepin. |
Promethazine | Promethazine The serum concentration of Doxepin can be increased when it is combined with Promethazine. |
Meclofenamate | Meclofenamate Meclofenamic acid may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Nitrofurantoin | Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Griseofulvin | Griseofulvin The metabolism of Doxepin can be increased when combined with Griseofulvin. |
Digoxin | Digoxin Digoxin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Loxapine | Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Doxepin. |
Chloroquine | Chloroquine The metabolism of Doxepin can be decreased when combined with Chloroquine. |
Quinine | Quinine The metabolism of Doxepin can be decreased when combined with Quinine. |
Ethosuximide | Ethosuximide Ethosuximide may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Triamterene | Triamterene The metabolism of Doxepin can be decreased when combined with Triamterene. |
Lactulose | Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Doxepin. |
Sulfinpyrazone | Sulfinpyrazone The metabolism of Doxepin can be decreased when combined with Sulfinpyrazone. |
Chlorothiazide | Chlorothiazide Doxepin may increase the excretion rate of Chlorothiazide which could result in a lower serum level and potentially a reduction in efficacy. |
Chlorthalidone | Chlorthalidone Doxepin may increase the excretion rate of Chlorthalidone which could result in a lower serum level and potentially a reduction in efficacy. |
Metolazone | Metolazone Doxepin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy. |
Isosorbide | Isosorbide Isosorbide may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy. |
Clindamycin Injection | Clindamycin Injection Doxepin may increase the neurotoxic activities of Clindamycin. |
Secobarbital | Secobarbital Secobarbital may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Desipramine | Desipramine The metabolism of Desipramine can be decreased when combined with Doxepin. |
Amitriptyline | Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Doxepin. |
Imipramine | Imipramine Imipramine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Probenecid | Probenecid The metabolism of Doxepin can be decreased when combined with Probenecid. |
Quinidine | Quinidine Quinidine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Procainamide | Procainamide The metabolism of Doxepin can be decreased when combined with Procainamide. |
Isoniazid | Isoniazid The metabolism of Doxepin can be decreased when combined with Isoniazid. |
Pyrazinamide | Pyrazinamide Pyrazinamide may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Rifampin | Rifampin The metabolism of Doxepin can be increased when combined with Rifampicin. |
Disopyramide | Disopyramide Doxepin may increase the central nervous system depressant (CNS depressant) activities of Disopyramide. |
Valproic Acid | Valproic Acid Valproic acid may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Tamoxifen | Tamoxifen The metabolism of Doxepin can be decreased when combined with Tamoxifen. |
Butabarbital | Butabarbital Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Levothyroxine | Levothyroxine The risk or severity of Cardiac Arrhythmia and CNS stimulation can be increased when Levothyroxine is combined with Doxepin. |
Liothyronine | Liothyronine The risk or severity of Cardiac Arrhythmia can be increased when Liothyronine is combined with Doxepin. |
Methimazole | Methimazole The risk or severity of Cardiac Arrhythmia can be increased when Methimazole is combined with Doxepin. |
Propylthiouracil | Propylthiouracil The risk or severity of Cardiac Arrhythmia can be increased when Propylthiouracil is combined with Doxepin. |
Chlorpropamide | Chlorpropamide Chlorpropamide may decrease the hypoglycemic activities of Doxepin. |
Glucagon Injection | Glucagon Injection Doxepin may increase the gastrointestinal motility reducing activities of Glucagon. |
Tolbutamide | Tolbutamide Tolbutamide may decrease the hypoglycemic activities of Doxepin. |
Tolazamide | Tolazamide Tolazamide may decrease the hypoglycemic activities of Doxepin. |
Dextromethorphan | Dextromethorphan Dextromethorphan may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Cyclobenzaprine | Cyclobenzaprine The risk or severity of CNS depression can be increased when Cyclobenzaprine is combined with Doxepin. |
Niacin | Niacin The metabolism of Doxepin can be decreased when combined with Niacin. |
Baclofen | Baclofen The risk or severity of CNS depression and hypotonia can be increased when Baclofen is combined with Doxepin. |
Doxylamine | Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Cyproheptadine | Cyproheptadine Cyproheptadine may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Clemastine | Clemastine Clemastine may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Chlorpheniramine | Chlorpheniramine Chlorpheniramine may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Brompheniramine | Brompheniramine Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Meclizine | Meclizine Meclizine may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Ethambutol | Ethambutol Ethambutol may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Methyclothiazide | Methyclothiazide Doxepin may increase the excretion rate of Methyclothiazide which could result in a lower serum level and potentially a reduction in efficacy. |
Hydrochlorothiazide | Hydrochlorothiazide Doxepin may decrease the excretion rate of Hydrochlorothiazide which could result in a higher serum level. |
Dantrolene | Dantrolene Dantrolene may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Chlorzoxazone | Chlorzoxazone Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Carisoprodol | Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Doxepin. |
Methocarbamol | Methocarbamol Methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Pyridoxine | Pyridoxine Pyridoxine may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Folic Acid | Folic Acid Folic acid may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Disulfiram | Disulfiram The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Doxepin. |
Propranolol (Cardiovascular) | Propranolol (Cardiovascular) The metabolism of Doxepin can be decreased when combined with Propranolol. |
Minoxidil | Minoxidil Doxepin may decrease the antihypertensive activities of Minoxidil. |
Pseudoephedrine | Pseudoephedrine Pseudoephedrine may decrease the sedative and stimulatory activities of Doxepin. |
Nortriptyline | Nortriptyline The serum concentration of Doxepin can be increased when it is combined with Nortriptyline. |
Spironolactone | Spironolactone Spironolactone may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy. |
Amphotericin B Injection | Amphotericin B Injection Amphotericin B may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Phytonadione | Phytonadione Phylloquinone may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Amikacin Injection | Amikacin Injection Amikacin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Nadolol | Nadolol The metabolism of Nadolol can be decreased when combined with Doxepin. |
Butorphanol Injection | Butorphanol Injection The risk or severity of adverse effects can be increased when Butorphanol is combined with Doxepin. |
Nalbuphine Injection | Nalbuphine Injection The risk or severity of adverse effects can be increased when Nalbuphine is combined with Doxepin. |
Allopurinol | Allopurinol Allopurinol may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Oxytocin Injection | Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Doxepin. |
Trimethobenzamide | Trimethobenzamide Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Flavoxate | Flavoxate Doxepin may increase the central nervous system depressant (CNS depressant) activities of Flavoxate. |
Papaverine | Papaverine The risk or severity of QTc prolongation can be increased when Doxepin is combined with Papaverine. |
Fluorouracil Injection | Fluorouracil Injection The metabolism of Doxepin can be decreased when combined with Fluorouracil. |
Colchicine | Colchicine Doxepin may decrease the excretion rate of Colchicine which could result in a higher serum level. |
Cefaclor | Cefaclor Cefaclor may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Cefadroxil | Cefadroxil Cefadroxil may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Cefazolin Injection | Cefazolin Injection Cefazolin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Cephalexin | Cephalexin Cephalexin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Cefoxitin Injection | Cefoxitin Injection Cefoxitin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Dacarbazine | Dacarbazine The metabolism of Doxepin can be decreased when combined with Dacarbazine. |
Acetazolamide | Acetazolamide Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Cefotaxime Injection | Cefotaxime Injection Cefotaxime may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Calcitonin Salmon Injection | Calcitonin Salmon Injection The risk or severity of Cardiac Arrhythmia can be increased when Salmon calcitonin is combined with Doxepin. |
Ketoconazole | Ketoconazole Doxepin can cause a decrease in the absorption of Ketoconazole resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Pyrantel | Pyrantel Pyrantel may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Thiotepa Injection | Thiotepa Injection The therapeutic efficacy of Doxepin can be decreased when used in combination with Thiotepa. |
Vincristine Injection | Vincristine Injection Vincristine may increase the neurotoxic activities of Doxepin. |
Captopril | Captopril Doxepin may decrease the antihypertensive activities of Captopril. |
Dipyridamole | Dipyridamole The risk or severity of hypotension, dyspepsia, and headache can be increased when Dipyridamole is combined with Doxepin. |
Isoxsuprine | Isoxsuprine The risk or severity of hypertension can be increased when Doxepin is combined with Isoxsuprine. |
Vinblastine | Vinblastine The metabolism of Doxepin can be decreased when combined with Vinblastine. |
Ethacrynic Acid | Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Colistimethate Injection | Colistimethate Injection Colistimethate may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Metoprolol | Metoprolol The metabolism of Doxepin can be decreased when combined with Metoprolol. |
Hydroxyzine | Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Doxepin. |
Thiothixene | Thiothixene The risk or severity of adverse effects can be increased when Doxepin is combined with Thiothixene. |
Aspirin | Aspirin Acetylsalicylic acid may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Salsalate | Salsalate Doxepin may decrease the excretion rate of Salsalate which could result in a higher serum level. |
Alprazolam | Alprazolam Alprazolam may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Temazepam | Temazepam Temazepam may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Triazolam | Triazolam Triazolam may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Dicyclomine | Dicyclomine Doxepin may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine. |
Hyoscyamine | Hyoscyamine Doxepin may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine. |
Propantheline | Propantheline Doxepin may increase the central nervous system depressant (CNS depressant) activities of Propantheline. |
Trimethoprim | Trimethoprim Trimethoprim may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Diltiazem | Diltiazem The metabolism of Doxepin can be decreased when combined with Diltiazem. |
Nifedipine | Nifedipine The metabolism of Doxepin can be decreased when combined with Nifedipine. |
Timolol | Timolol The metabolism of Timolol can be decreased when combined with Doxepin. |
Verapamil | Verapamil Verapamil may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Atenolol | Atenolol The metabolism of Atenolol can be decreased when combined with Doxepin. |
Pindolol | Pindolol Pindolol may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Cisplatin Injection | Cisplatin Injection Cisplatin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Diflunisal | Diflunisal Diflunisal may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Piroxicam | Piroxicam Piroxicam may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Bumetanide | Bumetanide Bumetanide may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Streptozocin | Streptozocin The metabolism of Doxepin can be increased when combined with Streptozocin. |
Etoposide | Etoposide The metabolism of Doxepin can be decreased when combined with Etoposide. |
Glyburide | Glyburide The metabolism of Doxepin can be decreased when combined with Glyburide. |
Glipizide | Glipizide Glipizide may decrease the hypoglycemic activities of Doxepin. |
Indapamide | Indapamide Doxepin may increase the excretion rate of Indapamide which could result in a lower serum level and potentially a reduction in efficacy. |
Amoxicillin | Amoxicillin Amoxicillin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Nafcillin Injection | Nafcillin Injection The metabolism of Doxepin can be increased when combined with Nafcillin. |
Oxacillin Injection | Oxacillin Injection Oxacillin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Pentoxifylline | Pentoxifylline The metabolism of Doxepin can be decreased when combined with Pentoxifylline. |
Pentamidine Injection | Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Doxepin. |
Ceftriaxone Injection | Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Labetalol | Labetalol Labetalol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Auranofin | Auranofin Auranofin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Leuprolide Injection | Leuprolide Injection The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Doxepin. |
Gemfibrozil | Gemfibrozil The metabolism of Doxepin can be decreased when combined with Gemfibrozil. |
Guanabenz | Guanabenz The risk or severity of hypertension can be increased when Doxepin is combined with Guanabenz. |
Dipivefrin Ophthalmic | Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Ceftazidime Injection | Ceftazidime Injection Ceftazidime may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Ketoprofen | Ketoprofen Ketoprofen may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Cefotetan Injection | Cefotetan Injection Cefotetan may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Pimozide | Pimozide The metabolism of Doxepin can be decreased when combined with Pimozide. |
Enalapril | Enalapril Doxepin may decrease the antihypertensive activities of Enalapril. |
Flurbiprofen | Flurbiprofen Flurbiprofen may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Amiodarone | Amiodarone The metabolism of Doxepin can be decreased when combined with Amiodarone. |
Aztreonam Injection | Aztreonam Injection Aztreonam may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Buspirone | Buspirone The metabolism of Buspirone can be decreased when combined with Doxepin. |
Lovastatin | Lovastatin The metabolism of Doxepin can be decreased when combined with Lovastatin. |
Ciprofloxacin | Ciprofloxacin The metabolism of Doxepin can be decreased when combined with Ciprofloxacin. |
Mesalamine | Mesalamine The therapeutic efficacy of Mesalazine can be decreased when used in combination with Doxepin. |
Diclofenac | Diclofenac The metabolism of Doxepin can be decreased when combined with Diclofenac. |
Fluoxetine | Fluoxetine The serum concentration of Doxepin can be increased when it is combined with Fluoxetine. |
Nimodipine | Nimodipine The risk or severity of QTc prolongation can be increased when Doxepin is combined with Nimodipine. |
Interferon Alfa-2b Injection | Interferon Alfa-2b Injection The metabolism of Doxepin can be decreased when combined with Interferon alfa-2b. |
Clozapine | Clozapine Clozapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Estazolam | Estazolam Estazolam may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Idarubicin | Idarubicin The metabolism of Idarubicin can be decreased when combined with Doxepin. |
Ofloxacin | Ofloxacin The metabolism of Doxepin can be decreased when combined with Ofloxacin. |
Didanosine | Didanosine Didanosine may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Pentostatin Injection | Pentostatin Injection Pentostatin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Clarithromycin | Clarithromycin The risk or severity of QTc prolongation can be increased when Doxepin is combined with Clarithromycin. |
Benazepril | Benazepril Doxepin may decrease the antihypertensive activities of Benazepril. |
Etodolac | Etodolac Etodolac may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Felodipine | Felodipine The metabolism of Doxepin can be decreased when combined with Felodipine. |
Fosinopril | Fosinopril Doxepin may decrease the excretion rate of Fosinopril which could result in a higher serum level. |
Nabumetone | Nabumetone The metabolism of Doxepin can be decreased when combined with Nabumetone. |
Quinapril | Quinapril Doxepin may decrease the antihypertensive activities of Quinapril. |
Ramipril | Ramipril Doxepin may decrease the antihypertensive activities of Ramipril. |
Simvastatin | Simvastatin The metabolism of Doxepin can be decreased when combined with Simvastatin. |
Amlodipine | Amlodipine The risk or severity of hypotension can be increased when Amlodipine is combined with Doxepin. |
Teniposide Injection | Teniposide Injection The metabolism of Doxepin can be decreased when combined with Teniposide. |
Itraconazole | Itraconazole Doxepin can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Lisinopril | Lisinopril Doxepin may decrease the excretion rate of Lisinopril which could result in a higher serum level. |
Oxaprozin | Oxaprozin Oxaprozin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Atovaquone | Atovaquone The metabolism of Doxepin can be decreased when combined with Atovaquone. |
Rifabutin | Rifabutin The metabolism of Doxepin can be increased when combined with Rifabutin. |
Sotalol | Sotalol The metabolism of Doxepin can be decreased when combined with Sotalol. |
Bisoprolol | Bisoprolol Doxepin may increase the orthostatic hypotensive activities of Bisoprolol. |
Zolpidem | Zolpidem Doxepin may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
Doxazosin | Doxazosin Doxazosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Terazosin | Terazosin Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Terazosin. |
Isradipine | Isradipine The risk or severity of QTc prolongation can be increased when Doxepin is combined with Isradipine. |
Omeprazole | Omeprazole The metabolism of Doxepin can be increased when combined with Omeprazole. |
Cisapride | Cisapride The metabolism of Doxepin can be decreased when combined with Cisapride. |
Gabapentin | Gabapentin The risk or severity of adverse effects can be increased when Gabapentin is combined with Doxepin. |
Fluvastatin | Fluvastatin The metabolism of Doxepin can be decreased when combined with Fluvastatin. |
Venlafaxine | Venlafaxine The metabolism of Doxepin can be decreased when combined with Venlafaxine. |
Nizatidine | Nizatidine The therapeutic efficacy of Doxepin can be decreased when used in combination with Nizatidine. |
Stavudine | Stavudine Stavudine may increase the neurotoxic activities of Doxepin. |
Fluvoxamine | Fluvoxamine The metabolism of Doxepin can be decreased when combined with Fluvoxamine. |
Nefazodone | Nefazodone Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Nefazodone. |
Lamotrigine | Lamotrigine Lamotrigine may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Losartan | Losartan The metabolism of Doxepin can be decreased when combined with Losartan. |
Valacyclovir | Valacyclovir Valaciclovir may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Tramadol | Tramadol The risk or severity of serotonin syndrome can be increased when Doxepin is combined with Tramadol. |
Vinorelbine Injection | Vinorelbine Injection The metabolism of Doxepin can be decreased when combined with Vinorelbine. |
Carboplatin Injection | Carboplatin Injection Carboplatin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Moexipril | Moexipril The risk or severity of QTc prolongation can be increased when Moexipril is combined with Doxepin. |
Lansoprazole | Lansoprazole The metabolism of Doxepin can be decreased when combined with Lansoprazole. |
Ifosfamide Injection | Ifosfamide Injection Doxepin may decrease the excretion rate of Ifosfamide which could result in a higher serum level. |
Nicardipine | Nicardipine Nicardipine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Bupropion | Bupropion The risk or severity of seizure can be increased when Doxepin is combined with Bupropion. |
Ticlopidine | Ticlopidine The metabolism of Doxepin can be decreased when combined with Ticlopidine. |
Saquinavir | Saquinavir Doxepin can cause an increase in the absorption of Saquinavir resulting in an increased serum concentration and potentially a worsening of adverse effects. |
Metformin | Metformin Doxepin may decrease the hypoglycemic activities of Metformin. |
Nisoldipine | Nisoldipine The risk or severity of hypotension can be increased when Doxepin is combined with Nisoldipine. |
Lamivudine | Lamivudine Lamivudine may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Riluzole | Riluzole Riluzole may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Acarbose | Acarbose Doxepin may decrease the hypoglycemic activities of Acarbose. |
Glimepiride | Glimepiride Glimepiride may decrease the hypoglycemic activities of Doxepin. |
Gemcitabine Injection | Gemcitabine Injection Gemcitabine may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Indinavir | Indinavir Doxepin can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Ritonavir | Ritonavir The serum concentration of Doxepin can be increased when it is combined with Ritonavir. |
Cidofovir Injection | Cidofovir Injection Cidofovir may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Meropenem Injection | Meropenem Injection Meropenem may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Clomipramine | Clomipramine The metabolism of Doxepin can be decreased when combined with Clomipramine. |
Zafirlukast | Zafirlukast The metabolism of Doxepin can be decreased when combined with Zafirlukast. |
Fosfomycin | Fosfomycin Fosfomycin may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Mirtazapine | Mirtazapine Doxepin may increase the serotonergic activities of Mirtazapine. |
Trandolapril | Trandolapril Doxepin may decrease the antihypertensive activities of Trandolapril. |
Topiramate | Topiramate The risk or severity of hyperthermia and oligohydrosis can be increased when Doxepin is combined with Topiramate. |
Zileuton | Zileuton The metabolism of Doxepin can be decreased when combined with Zileuton. |
Valsartan | Valsartan The metabolism of Doxepin can be decreased when combined with Valsartan. |
Insulin Lispro Injection | Insulin Lispro Injection The metabolism of Doxepin can be increased when combined with Insulin lispro. |
Pramipexole | Pramipexole Doxepin may increase the sedative activities of Pramipexole. |
Donepezil | Donepezil The therapeutic efficacy of Doxepin can be decreased when used in combination with Donepezil. |
Nelfinavir | Nelfinavir Doxepin can cause a decrease in the absorption of Nelfinavir resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Azithromycin | Azithromycin The risk or severity of QTc prolongation can be increased when Doxepin is combined with Azithromycin. |
Loratadine | Loratadine Doxepin may increase the anticholinergic activities of Loratadine. |
Carvedilol | Carvedilol Carvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin. |
Nilutamide | Nilutamide The metabolism of Doxepin can be decreased when combined with Nilutamide. |
Flutamide | Flutamide The metabolism of Doxepin can be decreased when combined with Flutamide. |
Selegiline | Selegiline Selegiline may increase the serotonergic activities of Doxepin. |
Bicalutamide | Bicalutamide The metabolism of Doxepin can be decreased when combined with Bicalutamide. |
Sertraline | Sertraline The metabolism of Doxepin can be decreased when combined with Sertraline. |
Propafenone | Propafenone The metabolism of Doxepin can be decreased when combined with Propafenone. |
Letrozole | Letrozole The metabolism of Doxepin can be decreased when combined with Letrozole. |
Irbesartan | Irbesartan The metabolism of Doxepin can be decreased when combined with Irbesartan. |
Tamsulosin | Tamsulosin Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Tamsulosin. |
Ropinirole | Ropinirole Doxepin may increase the sedative activities of Ropinirole. |
Finasteride | Finasteride The risk or severity of hypertension can be increased when Doxepin is combined with Finasteride. |
Quetiapine | Quetiapine Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Quetiapine. |
Cefepime Injection | Cefepime Injection Cefepime may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Cefprozil | Cefprozil Cefprozil may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Cefpodoxime | Cefpodoxime Doxepin can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Cetirizine | Cetirizine Cetirizine may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Paroxetine | Paroxetine The metabolism of Doxepin can be decreased when combined with Paroxetine. |
Tolcapone | Tolcapone The metabolism of Doxepin can be decreased when combined with Tolcapone. |
Citalopram | Citalopram The risk or severity of adverse effects can be increased when Doxepin is combined with Citalopram. |
Capecitabine | Capecitabine The metabolism of Doxepin can be decreased when combined with Capecitabine. |
Efavirenz | Efavirenz The metabolism of Doxepin can be decreased when combined with Efavirenz. |
Abacavir | Abacavir Abacavir may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Sildenafil | Sildenafil The metabolism of Doxepin can be decreased when combined with Sildenafil. |
Pioglitazone | Pioglitazone Doxepin may decrease the hypoglycemic activities of Pioglitazone. |
Celecoxib | Celecoxib The metabolism of Doxepin can be decreased when combined with Celecoxib. |
Rosiglitazone | Rosiglitazone The metabolism of Doxepin can be decreased when combined with Rosiglitazone. |
Tolterodine | Tolterodine Tolterodine may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Thalidomide | Thalidomide Doxepin may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. |
Oseltamivir | Oseltamivir Oseltamivir may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Balsalazide | Balsalazide Balsalazide may decrease the excretion rate of Doxepin which could result in a higher serum level. |
Nateglinide | Nateglinide The metabolism of Doxepin can be decreased when combined with Nateglinide. |
Galantamine | Galantamine The risk or severity of QTc prolongation can be increased when Doxepin is combined with Galantamine. |
Levetiracetam | Levetiracetam Levetiracetam may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Rabeprazole | Rabeprazole The metabolism of Doxepin can be decreased when combined with Rabeprazole. |
Terbinafine | Terbinafine The metabolism of Doxepin can be decreased when combined with Terbinafine. |
Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists