Doxepin (Insomnia)

Doxepin (Silenor) is used to treat insomnia (difficulty falling asleep or staying asleep) in people who have trouble staying asleep. Doxepin (Silenor) is in a class of medications called tricyclic antidepressants. It works by slowing activity in the brain to allow sleep.

Doxepin is also available as a capsule and liquid to treat depression and anxiety. This monograph only gives information about doxepin (Silenor) for insomnia. If you are using this medication for depression or anxiety, read the monograph entitled doxepin (depression, anxiety).

Doxepin (Silenor) comes as a tablet to take by mouth. It is usually taken once a day, within 30 minutes of bedtime. Do not take doxepin (Silenor) within 3 hours of a meal. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take doxepin (Silenor) exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

You will probably become very sleepy soon after you take doxepin (Silenor) and will remain sleepy for some time after you take the medication. Plan to go to bed right after you take doxepin (Silenor) and to stay in bed for 7 to 8 hours. Do not take doxepin (Silenor) if you will be unable to go to bed right away and remain asleep for 7 to 8 hours after taking the medication.

You should begin to sleep better during the first few days of treatment with doxepin (Silenor). If your sleep does not improve within 7-10 days, or gets worse call your doctor.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with doxepin (Silenor) and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking doxepin (Silenor),

• tell your doctor and pharmacist if you are allergic to doxepin (Silenor), amoxapine, loxapine, any other medications, or any of the ingredients in doxepin (Silenor) tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

• tell your doctor if you are taking a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking an MAO inhibitor within the past 14 days. Also tell your doctor if you are taking or receiving methylene blue (Provayblue) or linezolid (Zyvox). Your doctor will probably tell you not to take doxepin. If you stop taking doxepin, you should wait at least 14 days before you start to take an MAO inhibitor.

• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: cimetidine (Tagamet); medications for cough, cold, or allergies; quinidine (in Nuedexta); sedatives; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); other sleeping pills; tolazamide; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with doxepin (Silenor), so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

• tell your doctor if you have or have ever had glaucoma that is not being treated, or urinary retention (inability to empty your bladder completely or at all). Your doctor may tell you not to take doxepin (Silenor).

• tell your doctor if you have or have ever drunk large amounts of alcohol, used street drugs, or over-used prescription medications. Also tell your doctor if you have or have ever had depression, mental illness, suicidal thoughts, sleep apnea (a sleep disorder that causes breathing to stop for short periods during sleep), or kidney or liver disease.

• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking doxepin (Silenor), call your doctor.

• you should know that doxepin (Silenor) may make you drowsy. Do not drive a car, operate machinery, or do other dangerous activities at night after taking doxepin (Silenor). Do not drive a car or operate machinery the next day until you know how this medication affects you.

• you should know that alcohol can add to the drowsiness caused by this medication. Do not drink alcohol while you are taking doxepin (Silenor).

• you should know that some people who took doxepin (Silenor) got out of bed and drove their cars, prepared and ate food, had sex, made phone calls, were sleep-walking, or were involved in other activities while not fully awake. After they woke up, these people were usually unable to remember what they had done. Call your doctor right away if you find out that you have been driving or doing anything else unusual while you were sleeping.

Unless your doctor tells you otherwise, continue your normal diet.

Doxepin (Silenor) should only be taken at bedtime. If you did not take doxepin (Silenor) before you went to bed and you are having trouble sleeping, you may take doxepin (Silenor) if you will be able to stay in bed for at least 7 to 8 hours afterward. Do not take a double dose of doxepin (Silenor) to make up for a missed dose.

• Doxepin (Silenor) may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea

  • dizziness

• Doxepin (Silenor) may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, and excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

• irregular heart beat

• feeling agitated, confused, or drowsy

• trouble concentrating

• seizures

• muscle stiffness

• vomiting

• increase in pupil size

• hallucination (seeing things or hearing voices that do not exist)

• fever

• cold body temperature

• coma (loss of consciousness for a period of time)

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Moxifloxacin	Moxifloxacin The metabolism of Doxepin can be decreased when combined with Moxifloxacin.
Repaglinide	Repaglinide Doxepin may decrease the hypoglycemic activities of Repaglinide.
Montelukast	Montelukast The metabolism of Doxepin can be decreased when combined with Montelukast.
Insulin Glargine (rDNA origin) Injection	Insulin Glargine (rDNA origin) Injection The metabolism of Doxepin can be increased when combined with Insulin glargine.
Leflunomide	Leflunomide The serum concentration of Doxepin can be decreased when it is combined with Leflunomide.
Delavirdine	Delavirdine Doxepin can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nevirapine	Nevirapine The metabolism of Doxepin can be decreased when combined with Nevirapine.
Dolasetron	Dolasetron Dolasetron may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Aminophylline	Aminophylline The metabolism of Aminophylline can be decreased when combined with Doxepin.
Anagrelide	Anagrelide The metabolism of Doxepin can be decreased when combined with Anagrelide.
Bisacodyl	Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Doxepin.
Candesartan	Candesartan The metabolism of Doxepin can be decreased when combined with Candesartan.
Cilostazol	Cilostazol The metabolism of Cilostazol can be decreased when combined with Doxepin.
Clopidogrel	Clopidogrel The metabolism of Doxepin can be decreased when combined with Clopidogrel.
Diphenoxylate	Diphenoxylate The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Doxepin.
Erythromycin and Sulfisoxazole	Erythromycin and Sulfisoxazole The risk or severity of QTc prolongation can be increased when Doxepin is combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) The metabolism of Doxepin can be decreased when combined with Conjugated estrogens.
Fenofibrate	Fenofibrate The metabolism of Doxepin can be decreased when combined with Fenofibrate.
Guanfacine	Guanfacine Guanfacine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Magnesium Hydroxide	Magnesium Hydroxide Doxepin may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Magnesium Oxide	Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Doxepin.
Methylergonovine	Methylergonovine The risk or severity of hypertension can be increased when Methylergometrine is combined with Doxepin.
Miglitol	Miglitol Doxepin may decrease the hypoglycemic activities of Miglitol.
Mycophenolate	Mycophenolate Mycophenolic acid may decrease the excretion rate of Doxepin which could result in a higher serum level.
Naratriptan	Naratriptan The risk or severity of adverse effects can be increased when Naratriptan is combined with Doxepin.
Olsalazine	Olsalazine Doxepin may decrease the excretion rate of Olsalazine which could result in a higher serum level.
Paregoric	Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Doxepin.
Penbutolol	Penbutolol The metabolism of Acebutolol can be decreased when combined with Doxepin.
Pentazocine	Pentazocine The risk or severity of adverse effects can be increased when Pentazocine is combined with Doxepin.
Polyethylene glycol-electrolyte solution (PEG-ES)	Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Doxepin.
Potassium	Potassium Potassium may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone	Prednisone Prednisone may decrease the excretion rate of Doxepin which could result in a higher serum level.
Psyllium	Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Doxepin.
Ranitidine	Ranitidine The metabolism of Doxepin can be decreased when combined with Ranitidine.
Reserpine	Reserpine Reserpine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Rizatriptan	Rizatriptan Rizatriptan may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Sumatriptan	Sumatriptan Sumatriptan may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Tacrolimus	Tacrolimus Tacrolimus may decrease the excretion rate of Doxepin which could result in a higher serum level.
Tizanidine	Tizanidine Tizanidine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Zolmitriptan	Zolmitriptan The metabolism of Doxepin can be decreased when combined with Zolmitriptan.
Ampicillin Injection	Ampicillin Injection Ampicillin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Doxycycline Injection	Doxycycline Injection Doxycycline may decrease the excretion rate of Doxepin which could result in a higher serum level.
Famotidine Injection	Famotidine Injection The risk or severity of QTc prolongation can be increased when Famotidine is combined with Doxepin.
Fluconazole Injection	Fluconazole Injection The metabolism of Doxepin can be decreased when combined with Fluconazole.
Foscarnet Injection	Foscarnet Injection Foscarnet may decrease the excretion rate of Doxepin which could result in a higher serum level.
Hydromorphone Injection	Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Doxepin.
Interferon Beta-1b Injection	Interferon Beta-1b Injection The metabolism of Doxepin can be decreased when combined with Interferon beta-1b.
Interferon Gamma-1b Injection	Interferon Gamma-1b Injection The metabolism of Doxepin can be decreased when combined with Interferon gamma-1b.
Levofloxacin Injection	Levofloxacin Injection The metabolism of Doxepin can be decreased when combined with Levofloxacin.
Meperidine Injection	Meperidine Injection The risk or severity of adverse effects can be increased when Meperidine is combined with Doxepin.
Metoclopramide Injection	Metoclopramide Injection The risk or severity of sedation can be increased when Metoclopramide is combined with Doxepin.
Metronidazole Injection	Metronidazole Injection The metabolism of Doxepin can be decreased when combined with Metronidazole.
Morphine Injection	Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Doxepin.
Pamidronate Injection	Pamidronate Injection Pamidronic acid may decrease the excretion rate of Doxepin which could result in a higher serum level.
Vancomycin Injection	Vancomycin Injection Doxepin may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection	Zidovudine Injection The metabolism of Doxepin can be decreased when combined with Zidovudine.
Altretamine	Altretamine Amphetamine may decrease the sedative and stimulatory activities of Doxepin.
Cefuroxime	Cefuroxime Doxepin can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cyclosporine	Cyclosporine The metabolism of Doxepin can be decreased when combined with Cyclosporine.
Ondansetron	Ondansetron Ondansetron may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Granisetron	Granisetron The risk or severity of QTc prolongation can be increased when Doxepin is combined with Granisetron.
Torsemide	Torsemide The metabolism of Doxepin can be decreased when combined with Torasemide.
Olanzapine	Olanzapine Olanzapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Alosetron	Alosetron Alosetron may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Dofetilide	Dofetilide The risk or severity of QTc prolongation can be increased when Doxepin is combined with Dofetilide.
Entacapone	Entacapone Entacapone may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Eprosartan	Eprosartan Doxepin may decrease the antihypertensive activities of Eprosartan.
Hydroxychloroquine	Hydroxychloroquine The metabolism of Doxepin can be decreased when combined with Hydroxychloroquine.
Meloxicam	Meloxicam Meloxicam may decrease the excretion rate of Doxepin which could result in a higher serum level.
Oxcarbazepine	Oxcarbazepine Oxcarbazepine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Pantoprazole	Pantoprazole The metabolism of Doxepin can be decreased when combined with Pantoprazole.
Risedronate	Risedronate Doxepin can cause an increase in the absorption of Risedronic acid resulting in an increased serum concentration and potentially a worsening of adverse effects.
Telmisartan	Telmisartan The metabolism of Doxepin can be decreased when combined with Telmisartan.
Temozolomide	Temozolomide Temozolomide may decrease the excretion rate of Doxepin which could result in a higher serum level.
Zaleplon	Zaleplon Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Anakinra	Anakinra The metabolism of Doxepin can be increased when combined with Anakinra.
Desloratadine	Desloratadine Desloratadine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Linezolid	Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Doxepin.
Rivastigmine	Rivastigmine The therapeutic efficacy of Doxepin can be decreased when used in combination with Rivastigmine.
Trimipramine	Trimipramine Trimipramine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Etanercept Injection	Etanercept Injection The metabolism of Doxepin can be increased when combined with Etanercept.
Glycopyrrolate	Glycopyrrolate The risk or severity of adverse effects can be increased when Doxepin is combined with Glycopyrronium.
Modafinil	Modafinil The metabolism of Doxepin can be decreased when combined with Modafinil.
Perindopril	Perindopril Doxepin may decrease the antihypertensive activities of Perindopril.
Tenofovir	Tenofovir Tenofovir may decrease the excretion rate of Doxepin which could result in a higher serum level.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate Doxepin may decrease the excretion rate of Choline magnesium trisalicylate which could result in a higher serum level.
Dutasteride	Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Doxepin.
Epinephrine Injection	Epinephrine Injection Epinephrine may increase the vasopressor activities of Doxepin.
Eplerenone	Eplerenone Doxepin may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram	Escitalopram The risk or severity of serotonin syndrome can be increased when Doxepin is combined with Escitalopram.
Olmesartan	Olmesartan Doxepin may decrease the antihypertensive activities of Olmesartan.
Zonisamide	Zonisamide Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Adalimumab Injection	Adalimumab Injection The metabolism of Doxepin can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole.
Atomoxetine	Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Doxepin.
Dexmethylphenidate	Dexmethylphenidate The serum concentration of Doxepin can be increased when it is combined with Dexmethylphenidate.
Atazanavir	Atazanavir Doxepin can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Almotriptan	Almotriptan Almotriptan may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Eletriptan	Eletriptan Eletriptan may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Mefloquine	Mefloquine The risk or severity of QTc prolongation can be increased when Mefloquine is combined with Doxepin.
Polyethylene Glycol 3350	Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Doxepin.
Rosuvastatin	Rosuvastatin The metabolism of Doxepin can be decreased when combined with Rosuvastatin.
Vardenafil	Vardenafil The risk or severity of QTc prolongation can be increased when Vardenafil is combined with Doxepin.
Alfuzosin	Alfuzosin Alfuzosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Aprepitant	Aprepitant The metabolism of Doxepin can be decreased when combined with Aprepitant.
Emtricitabine	Emtricitabine Emtricitabine may decrease the excretion rate of Doxepin which could result in a higher serum level.
Interferon Beta-1a Subcutaneous Injection	Interferon Beta-1a Subcutaneous Injection The metabolism of Doxepin can be decreased when combined with Interferon beta-1a.
Memantine	Memantine The metabolism of Doxepin can be decreased when combined with Memantine.
Tegaserod	Tegaserod The metabolism of Doxepin can be decreased when combined with Tegaserod.
Tadalafil	Tadalafil The risk or severity of hypotension, dyspepsia, and headache can be increased when Doxepin is combined with Tadalafil.
Fosamprenavir	Fosamprenavir Doxepin can cause a decrease in the absorption of Fosamprenavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Frovatriptan	Frovatriptan The metabolism of Doxepin can be decreased when combined with Frovatriptan.
Gemifloxacin	Gemifloxacin The metabolism of Doxepin can be decreased when combined with Gemifloxacin.
Progesterone	Progesterone The metabolism of Doxepin can be decreased when combined with Progesterone.
Apomorphine Injection	Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Doxepin.
Infliximab Injection	Infliximab Injection The metabolism of Doxepin can be increased when combined with Infliximab.
Oxandrolone	Oxandrolone The metabolism of Doxepin can be decreased when combined with Oxandrolone.
Protriptyline	Protriptyline Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Rifaximin	Rifaximin The metabolism of Doxepin can be increased when combined with Rifaximin.
Duloxetine	Duloxetine The metabolism of Doxepin can be decreased when combined with Duloxetine.
Tinidazole	Tinidazole Tinidazole may decrease the excretion rate of Doxepin which could result in a higher serum level.
Trospium	Trospium Doxepin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan	Bosentan The metabolism of Doxepin can be increased when combined with Bosentan.
Cefditoren	Cefditoren Cefdinir may decrease the excretion rate of Doxepin which could result in a higher serum level.
Cinacalcet	Cinacalcet The metabolism of Doxepin can be decreased when combined with Cinacalcet.
Cyanocobalamin Injection	Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Erlotinib	Erlotinib Doxepin can cause a decrease in the absorption of Erlotinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Eszopiclone	Eszopiclone The risk or severity of CNS depression can be increased when Doxepin is combined with Eszopiclone.
Ganciclovir	Ganciclovir Ganciclovir may decrease the excretion rate of Doxepin which could result in a higher serum level.
Insulin Aspart (rDNA Origin) Injection	Insulin Aspart (rDNA Origin) Injection Doxepin may decrease the hypoglycemic activities of Insulin aspart.
Ribavirin	Ribavirin Ribavirin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Solifenacin	Solifenacin Doxepin may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Valganciclovir	Valganciclovir Doxepin may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole	Voriconazole The metabolism of Doxepin can be decreased when combined with Voriconazole.
Adefovir	Adefovir Adefovir may decrease the excretion rate of Doxepin which could result in a higher serum level.
Dextroamphetamine	Dextroamphetamine Amphetamine may decrease the sedative and stimulatory activities of Doxepin.
Entecavir	Entecavir The metabolism of Doxepin can be decreased when combined with Entecavir.
Peginterferon Alfa-2a Injection	Peginterferon Alfa-2a Injection The metabolism of Doxepin can be decreased when combined with Peginterferon alfa-2a.
Peginterferon Alfa-2b (PEG-Intron)	Peginterferon Alfa-2b (PEG-Intron) The serum concentration of Doxepin can be increased when it is combined with Peginterferon alfa-2b.
Pramlintide Injection	Pramlintide Injection The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Doxepin.
Sodium Oxybate	Sodium Oxybate Doxepin may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Exenatide Injection	Exenatide Injection Doxepin may decrease the hypoglycemic activities of Exenatide.
Ibandronate	Ibandronate The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Doxepin.
Isocarboxazid	Isocarboxazid Doxepin may increase the serotonergic activities of Isocarboxazid.
Ramelteon	Ramelteon Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Darifenacin	Darifenacin The metabolism of Doxepin can be decreased when combined with Darifenacin.
Fentanyl	Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Doxepin.
Pregabalin	Pregabalin The therapeutic efficacy of Doxepin can be increased when used in combination with Pregabalin.
Deferasirox	Deferasirox The serum concentration of Doxepin can be increased when it is combined with Deferasirox.
Phenylephrine	Phenylephrine Doxepin may increase the vasopressor activities of Phenylephrine.
Tipranavir	Tipranavir The metabolism of Doxepin can be decreased when combined with Tipranavir.
Felbamate	Felbamate The metabolism of Doxepin can be decreased when combined with Felbamate.
Insulin Detemir (rDNA Origin) Injection	Insulin Detemir (rDNA Origin) Injection Doxepin may decrease the hypoglycemic activities of Insulin detemir.
Ranolazine	Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Doxepin.
Abatacept Injection	Abatacept Injection The metabolism of Doxepin can be increased when combined with Abatacept.
Rasagiline	Rasagiline Rasagiline may increase the serotonergic activities of Doxepin.
Imatinib	Imatinib The metabolism of Doxepin can be decreased when combined with Imatinib.
Sitagliptin	Sitagliptin Doxepin may decrease the hypoglycemic activities of Sitagliptin.
Varenicline	Varenicline Doxepin may decrease the excretion rate of Varenicline which could result in a higher serum level.
Gefitinib	Gefitinib Doxepin can cause a decrease in the absorption of Gefitinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Albuterol	Albuterol The risk or severity of QTc prolongation can be increased when Salbutamol is combined with Doxepin.
Paliperidone	Paliperidone Paliperidone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Bortezomib	Bortezomib The risk or severity of QTc prolongation can be increased when Bortezomib is combined with Doxepin.
Clofarabine Injection	Clofarabine Injection Clofarabine may decrease the excretion rate of Doxepin which could result in a higher serum level.
Insulin Glulisine (rDNA origin) Injection	Insulin Glulisine (rDNA origin) Injection The metabolism of Doxepin can be increased when combined with Insulin glulisine.
Lubiprostone	Lubiprostone Doxepin may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Oxaliplatin Injection	Oxaliplatin Injection The risk or severity of QTc prolongation can be increased when Doxepin is combined with Oxaliplatin.
Posaconazole	Posaconazole The risk or severity of QTc prolongation can be increased when Doxepin is combined with Posaconazole.
Primaquine	Primaquine The metabolism of Doxepin can be decreased when combined with Primaquine.
Aliskiren	Aliskiren Doxepin may decrease the antihypertensive activities of Aliskiren.
Bismuth Subsalicylate	Bismuth Subsalicylate Doxepin may increase the neurotoxic activities of Bismuth subsalicylate.
Pemetrexed Injection	Pemetrexed Injection Pemetrexed may decrease the excretion rate of Doxepin which could result in a higher serum level.
Dimenhydrinate	Dimenhydrinate Dimenhydrinate may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Lisdexamfetamine	Lisdexamfetamine Lisdexamfetamine may decrease the sedative and stimulatory activities of Doxepin.
Nabilone	Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Vorinostat	Vorinostat The risk or severity of QTc prolongation can be increased when Doxepin is combined with Vorinostat.
Sorafenib	Sorafenib The metabolism of Doxepin can be decreased when combined with Sorafenib.
Sunitinib	Sunitinib Doxepin may decrease the hypoglycemic activities of Sunitinib.
Dronabinol	Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Lapatinib	Lapatinib The risk or severity of QTc prolongation can be increased when Doxepin is combined with Lapatinib.
Levocetirizine	Levocetirizine Levocetirizine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Pegaptanib Injection	Pegaptanib Injection Doxepin may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib	Dasatinib Doxepin can cause a decrease in the absorption of Dasatinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Mexiletine	Mexiletine The metabolism of Doxepin can be decreased when combined with Mexiletine.
Armodafinil	Armodafinil The metabolism of Doxepin can be decreased when combined with Armodafinil.
Azacitidine Injection	Azacitidine Injection Azacitidine may decrease the excretion rate of Doxepin which could result in a higher serum level.
Paclitaxel (with polyoxyethylated castor oil) Injection	Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Doxepin.
Temsirolimus	Temsirolimus The metabolism of Doxepin can be decreased when combined with Temsirolimus.
Lenalidomide	Lenalidomide Lenalidomide may decrease the excretion rate of Doxepin which could result in a higher serum level.
Nilotinib	Nilotinib Doxepin can cause a decrease in the absorption of Nilotinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Toremifene	Toremifene The risk or severity of QTc prolongation can be increased when Doxepin is combined with Toremifene.
Bexarotene	Bexarotene The metabolism of Doxepin can be decreased when combined with Bexarotene.
Budesonide	Budesonide Budesonide can cause a decrease in the absorption of Doxepin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Chloramphenicol Injection	Chloramphenicol Injection The metabolism of Doxepin can be decreased when combined with Chloramphenicol.
Desmopressin	Desmopressin The risk or severity of hyponatremia and water intoxication can be increased when Doxepin is combined with Desmopressin.
Betaine	Betaine The therapeutic efficacy of Doxepin can be decreased when used in combination with Glycine betaine.
OnabotulinumtoxinA Injection	OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Doxepin is combined with Botulinum toxin type A.
RimabotulinumtoxinB Injection	RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Doxepin is combined with Botulinum Toxin Type B.
Doripenem Injection	Doripenem Injection Doxepin may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine	Etravirine The metabolism of Doxepin can be decreased when combined with Etravirine.
Arsenic Trioxide Injection	Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Doxepin is combined with Arsenic trioxide.
Desvenlafaxine	Desvenlafaxine The risk or severity of adverse effects can be increased when Doxepin is combined with Desvenlafaxine.
Cevimeline	Cevimeline The metabolism of Cevimeline can be decreased when combined with Doxepin.
Nebivolol	Nebivolol The metabolism of Nebivolol can be decreased when combined with Doxepin.
Tretinoin	Tretinoin The metabolism of Doxepin can be decreased when combined with Tretinoin.
Bendamustine Injection	Bendamustine Injection The metabolism of Bendamustine can be decreased when combined with Doxepin.
Flecainide	Flecainide The metabolism of Flecainide can be decreased when combined with Doxepin.
Certolizumab Injection	Certolizumab Injection The metabolism of Doxepin can be increased when combined with Certolizumab pegol.
Daptomycin Injection	Daptomycin Injection Daptomycin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Praziquantel	Praziquantel The metabolism of Doxepin can be decreased when combined with Praziquantel.
Methylnaltrexone Injection	Methylnaltrexone Injection Doxepin may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Rufinamide	Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Doxepin.
Silodosin	Silodosin Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Silodosin.
Midazolam	Midazolam Midazolam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Naltrexone Injection	Naltrexone Injection The risk or severity of adverse effects can be increased when Naltrexone is combined with Doxepin.
Dexrazoxane Injection	Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Doxepin which could result in a higher serum level.
Eltrombopag	Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Doxepin.
Milnacipran	Milnacipran The risk or severity of adverse effects can be increased when Doxepin is combined with Milnacipran.
Dexlansoprazole	Dexlansoprazole The metabolism of Doxepin can be decreased when combined with Dexlansoprazole.
Plerixafor Injection	Plerixafor Injection Doxepin may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Sodium Phosphate	Sodium Phosphate The risk or severity of seizure can be increased when Doxepin is combined with Sodium phosphate, monobasic.
Fesoterodine	Fesoterodine Doxepin may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Degarelix Injection	Degarelix Injection The risk or severity of QTc prolongation can be increased when Doxepin is combined with Degarelix.
Betaxolol	Betaxolol The metabolism of Doxepin can be decreased when combined with Betaxolol.
Iloperidone	Iloperidone Iloperidone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Prasugrel	Prasugrel Doxepin may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Lacosamide	Lacosamide Doxepin may increase the central nervous system depressant (CNS depressant) activities of Lacosamide.
Everolimus	Everolimus The metabolism of Doxepin can be decreased when combined with Everolimus.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy.
Dronedarone	Dronedarone Doxepin may increase the QTc-prolonging activities of Dronedarone.
AbobotulinumtoxinA Injection	AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Doxepin is combined with Botulinum toxin type A.
Pralatrexate Injection	Pralatrexate Injection Doxepin may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection	Palonosetron Injection Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Saxagliptin	Saxagliptin Doxepin may decrease the hypoglycemic activities of Saxagliptin.
Telavancin Injection	Telavancin Injection The risk or severity of QTc prolongation can be increased when Doxepin is combined with Telavancin.
Romidepsin Injection	Romidepsin Injection The risk or severity of QTc prolongation can be increased when Doxepin is combined with Romidepsin.
Tapentadol	Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Topotecan	Topotecan Topotecan may decrease the excretion rate of Doxepin which could result in a higher serum level.
Golimumab Injection	Golimumab Injection The metabolism of Doxepin can be increased when combined with Golimumab.
Pazopanib	Pazopanib The therapeutic efficacy of Pazopanib can be decreased when used in combination with Doxepin.
Asenapine	Asenapine Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Asenapine.
Vigabatrin	Vigabatrin Vigabatrin may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Pitavastatin	Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Doxepin.
Albendazole	Albendazole The metabolism of Doxepin can be decreased when combined with Albendazole.
Oxymorphone	Oxymorphone The risk or severity of adverse effects can be increased when Doxepin is combined with Oxymorphone.
Liraglutide Injection	Liraglutide Injection Doxepin may decrease the hypoglycemic activities of Liraglutide.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Doxepin can be increased when combined with Tocilizumab.
Dalfampridine	Dalfampridine The risk or severity of seizure can be increased when Dalfampridine is combined with Doxepin.
Eribulin Injection	Eribulin Injection The risk or severity of QTc prolongation can be increased when Doxepin is combined with Eribulin.
IncobotulinumtoxinA Injection	IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Doxepin is combined with Botulinum toxin type A.
Ceftaroline Injection	Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Doxepin which could result in a higher serum level.
Lurasidone	Lurasidone Doxepin may increase the hypotensive activities of Lurasidone.
Acetaminophen Injection	Acetaminophen Injection The metabolism of Doxepin can be decreased when combined with Acetaminophen.
Vilazodone	Vilazodone The metabolism of Vilazodone can be decreased when combined with Doxepin.
Ipilimumab Injection	Ipilimumab Injection Doxepin may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection	Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Terbutaline Injection	Terbutaline Injection The therapeutic efficacy of Doxepin can be decreased when used in combination with Terbutaline.
Roflumilast	Roflumilast Doxepin may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Linagliptin	Linagliptin Doxepin may decrease the hypoglycemic activities of Linagliptin.
Rilpivirine	Rilpivirine Doxepin can cause a decrease in the absorption of Rilpivirine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Potassium Iodide	Potassium Iodide The risk or severity of Cardiac Arrhythmia can be increased when Potassium Iodide is combined with Doxepin.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Doxepin can be decreased when combined with Cyclophosphamide.
Abiraterone	Abiraterone The serum concentration of Doxepin can be increased when it is combined with Abiraterone.
Triptorelin Injection	Triptorelin Injection The risk or severity of QTc prolongation can be increased when Doxepin is combined with Triptorelin.
Rivaroxaban	Rivaroxaban Doxepin may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor	Ticagrelor The metabolism of Doxepin can be decreased when combined with Ticagrelor.
Ruxolitinib	Ruxolitinib Doxepin may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Vandetanib	Vandetanib The risk or severity of QTc prolongation can be increased when Doxepin is combined with Vandetanib.
Clobazam	Clobazam The metabolism of Doxepin can be decreased when combined with Clobazam.
Vemurafenib	Vemurafenib The serum concentration of Doxepin can be increased when it is combined with Vemurafenib.
Vismodegib	Vismodegib The metabolism of Doxepin can be decreased when combined with Vismodegib.
Deferiprone	Deferiprone Doxepin may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib	Axitinib The metabolism of Axitinib can be decreased when combined with Doxepin.
Crizotinib	Crizotinib The risk or severity of QTc prolongation can be increased when Doxepin is combined with Crizotinib.
Cabergoline	Cabergoline Cabergoline may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Naloxone Injection	Naloxone Injection Doxepin may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ambrisentan	Ambrisentan Doxepin may decrease the antihypertensive activities of Ambrisentan.
Fondaparinux Injection	Fondaparinux Injection Fondaparinux may decrease the excretion rate of Doxepin which could result in a higher serum level.
Ezogabine	Ezogabine Tiagabine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Enzalutamide	Enzalutamide The metabolism of Doxepin can be increased when combined with Enzalutamide.
Mirabegron	Mirabegron The risk or severity of urinary retention can be increased when Doxepin is combined with Mirabegron.
Regorafenib	Regorafenib The metabolism of Doxepin can be decreased when combined with Regorafenib.
Bosutinib	Bosutinib Doxepin can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Linaclotide	Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Doxepin.
Teriflunomide	Teriflunomide The serum concentration of Doxepin can be decreased when it is combined with Teriflunomide.
Lorcaserin	Lorcaserin Doxepin may decrease the hypoglycemic activities of Mecasermin.
Cabozantinib (thyroid cancer)	Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Doxepin.
Teduglutide Injection	Teduglutide Injection Doxepin may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Bedaquiline	Bedaquiline The risk or severity of QTc prolongation can be increased when Doxepin is combined with Bedaquiline.
Alogliptin	Alogliptin The metabolism of Alogliptin can be decreased when combined with Doxepin.
Ponatinib	Ponatinib The metabolism of Ponatinib can be decreased when combined with Doxepin.
Pomalidomide	Pomalidomide Pomalidomide may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Apixaban	Apixaban The metabolism of Apixaban can be decreased when combined with Doxepin.
Canagliflozin	Canagliflozin Doxepin may decrease the hypoglycemic activities of Canagliflozin.
Methazolamide	Methazolamide Methazolamide may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib	Dabrafenib The serum concentration of Doxepin can be decreased when it is combined with Dabrafenib.
Ospemifene	Ospemifene The metabolism of Ospemifene can be decreased when combined with Doxepin.
Trametinib	Trametinib Doxepin may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran	Levomilnacipran The risk or severity of adverse effects can be increased when Doxepin is combined with Levomilnacipran.
Ertapenem Injection	Ertapenem Injection Ertapenem may decrease the excretion rate of Doxepin which could result in a higher serum level.
Vortioxetine	Vortioxetine Doxepin may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
Perampanel	Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Doxepin.
Avanafil	Avanafil The risk or severity of hypotension, dyspepsia, and headache can be increased when Avanafil is combined with Doxepin.
Ketorolac Injection	Ketorolac Injection Ketorolac may decrease the excretion rate of Doxepin which could result in a higher serum level.
Simeprevir	Simeprevir The metabolism of Doxepin can be decreased when combined with Simeprevir.
Sofosbuvir	Sofosbuvir Doxepin may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin	Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Doxepin.
Iron Sucrose Injection	Iron Sucrose Injection Doxepin can cause a decrease in the absorption of Iron sucrose resulting in a reduced serum concentration and potentially a decrease in efficacy.
Apremilast	Apremilast The metabolism of Doxepin can be increased when combined with Apremilast.
Droxidopa	Droxidopa Doxepin may increase the vasopressor activities of Droxidopa.
Ceritinib	Ceritinib The metabolism of Doxepin can be decreased when combined with Ceritinib.
Siltuximab Injection	Siltuximab Injection The metabolism of Doxepin can be increased when combined with Siltuximab.
Albiglutide Injection	Albiglutide Injection Doxepin may decrease the hypoglycemic activities of Albiglutide.
Eslicarbazepine	Eslicarbazepine Eslicarbazepine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Belinostat Injection	Belinostat Injection The metabolism of Doxepin can be increased when combined with Belinostat.
Testosterone Injection	Testosterone Injection The metabolism of Doxepin can be decreased when combined with Testosterone.
Oritavancin Injection	Oritavancin Injection The metabolism of Doxepin can be decreased when combined with Oritavancin.
Empagliflozin	Empagliflozin Doxepin may decrease the hypoglycemic activities of Empagliflozin.
Hydrocodone	Hydrocodone Hydrocodone may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Suvorexant	Suvorexant Doxepin may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Dulaglutide Injection	Dulaglutide Injection Doxepin may decrease the hypoglycemic activities of Dulaglutide.
Edoxaban	Edoxaban Doxepin may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Peginterferon Beta-1a Injection	Peginterferon Beta-1a Injection The metabolism of Doxepin can be decreased when combined with Peginterferon beta-1a.
Methamphetamine	Methamphetamine Metamfetamine may decrease the sedative and stimulatory activities of Doxepin.
Tasimelteon	Tasimelteon Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Riociguat	Riociguat Doxepin may decrease the antihypertensive activities of Riociguat.
Pirfenidone	Pirfenidone The metabolism of Pirfenidone can be decreased when combined with Doxepin.
Secukinumab Injection	Secukinumab Injection The metabolism of Doxepin can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection Risperidone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Insulin Human Inhalation	Insulin Human Inhalation The metabolism of Doxepin can be increased when combined with Insulin human.
Lenvatinib	Lenvatinib The metabolism of Doxepin can be decreased when combined with Lenvatinib.
Naloxegol	Naloxegol The metabolism of Doxepin can be decreased when combined with Naloxegol.
Panobinostat	Panobinostat The metabolism of Doxepin can be decreased when combined with Panobinostat.
Haloperidol Injection	Haloperidol Injection The serum concentration of Doxepin can be increased when it is combined with Haloperidol.
Ivabradine	Ivabradine The risk or severity of QTc prolongation can be increased when Doxepin is combined with Ivabradine.
Amiloride	Amiloride Amiloride may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy.
Isavuconazonium Injection	Isavuconazonium Injection Doxepin can cause a decrease in the absorption of Isavuconazonium resulting in a reduced serum concentration and potentially a decrease in efficacy.
Macitentan	Macitentan Doxepin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Flibanserin	Flibanserin Flibanserin may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Rolapitant	Rolapitant The metabolism of Doxepin can be decreased when combined with Rolapitant.
Brexpiprazole	Brexpiprazole Brexpiprazole may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Ziprasidone Injection	Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Ziprasidone is combined with Doxepin.
Cariprazine	Cariprazine Cariprazine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Penicillin G Procaine Injection	Penicillin G Procaine Injection Doxepin may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline	Eluxadoline The risk or severity of constipation can be increased when Doxepin is combined with Eluxadoline.
Insulin Degludec (rDNA Origin) Injection	Insulin Degludec (rDNA Origin) Injection The metabolism of Doxepin can be increased when combined with Insulin degludec.
Trabectedin Injection	Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Doxepin.
Osimertinib	Osimertinib The serum concentration of Doxepin can be decreased when it is combined with Osimertinib.
Ixazomib	Ixazomib Doxepin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Rifapentine	Rifapentine The metabolism of Doxepin can be increased when combined with Rifapentine.
Lesinurad	Lesinurad Doxepin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Doxepin which could result in a higher serum level.
Brivaracetam Injection	Brivaracetam Injection Doxepin may increase the central nervous system depressant (CNS depressant) activities of Brivaracetam.
Cobicistat	Cobicistat The metabolism of Doxepin can be decreased when combined with Cobicistat.
Midodrine	Midodrine Midodrine may increase the vasopressor activities of Doxepin.
Selexipag	Selexipag Doxepin may decrease the antihypertensive activities of Selexipag.
Pimavanserin	Pimavanserin The risk or severity of adverse effects can be increased when Doxepin is combined with Pimavanserin.
Obeticholic Acid	Obeticholic Acid The metabolism of Doxepin can be decreased when combined with Obeticholic acid.
Diphenhydramine Injection	Diphenhydramine Injection Diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Furosemide Injection	Furosemide Injection Doxepin may decrease the excretion rate of Furosemide which could result in a higher serum level.
Rucaparib	Rucaparib The metabolism of Doxepin can be decreased when combined with Rucaparib.
Lixisenatide Injection	Lixisenatide Injection Doxepin may decrease the hypoglycemic activities of Lixisenatide.
Ribociclib	Ribociclib The risk or severity of QTc prolongation can be increased when Doxepin is combined with Ribociclib.
Plecanatide	Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Doxepin.
Deutetrabenazine	Deutetrabenazine The risk or severity of sedation and somnolence can be increased when Doxepin is combined with Deutetrabenazine.
Valbenazine	Valbenazine The metabolism of Valbenazine can be decreased when combined with Doxepin.
Safinamide	Safinamide Safinamide may increase the serotonergic activities of Doxepin.
Naldemedine	Naldemedine Doxepin may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Midostaurin	Midostaurin The metabolism of Doxepin can be decreased when combined with Midostaurin.
Enasidenib	Enasidenib The metabolism of Doxepin can be decreased when combined with Enasidenib.
Benznidazole	Benznidazole Doxepin may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin	Delafloxacin The risk or severity of QTc prolongation can be increased when Delafloxacin is combined with Doxepin.
Letermovir	Letermovir The metabolism of Letermovir can be decreased when combined with Doxepin.
Semaglutide Injection	Semaglutide Injection Doxepin may decrease the hypoglycemic activities of Semaglutide.
Tetrabenazine	Tetrabenazine The risk or severity of sedation and somnolence can be increased when Doxepin is combined with Tetrabenazine.
Ertugliflozin	Ertugliflozin Doxepin may decrease the hypoglycemic activities of Ertugliflozin.
Buprenorphine Injection	Buprenorphine Injection Doxepin may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide	Apalutamide The serum concentration of Doxepin can be increased when it is combined with Apalutamide.
Fostamatinib	Fostamatinib The risk or severity of hypotension, dyspepsia, and headache can be increased when Fostamatinib is combined with Doxepin.
Avatrombopag	Avatrombopag The metabolism of Doxepin can be increased when combined with Avatrombopag.
Baricitinib	Baricitinib Doxepin may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine	Lofexidine The therapeutic efficacy of Doxepin can be increased when used in combination with Lofexidine.
Plazomicin Injection	Plazomicin Injection Doxepin may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat	Eliglustat The metabolism of Eliglustat can be decreased when combined with Doxepin.
Encorafenib	Encorafenib The metabolism of Encorafenib can be decreased when combined with Doxepin.
Binimetinib	Binimetinib The metabolism of Binimetinib can be decreased when combined with Doxepin.
Ivosidenib	Ivosidenib The risk or severity of QTc prolongation can be increased when Doxepin is combined with Ivosidenib.
Elagolix	Elagolix The metabolism of Elagolix can be decreased when combined with Doxepin.
Tafenoquine	Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Doxepin.
Cannabidiol	Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Doxepin.
Dacomitinib	Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Doxepin.
Stiripentol	Stiripentol The metabolism of Doxepin can be decreased when combined with Stiripentol.
Gilteritinib	Gilteritinib The therapeutic efficacy of Doxepin can be decreased when used in combination with Gilteritinib.
Glasdegib	Glasdegib The risk or severity of QTc prolongation can be increased when Doxepin is combined with Glasdegib.
Lorlatinib	Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Doxepin.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection Doxepin may increase the neurotoxic activities of Paclitaxel.
Rifamycin	Rifamycin The metabolism of Doxepin can be increased when combined with Rifamycin.
Prucalopride	Prucalopride Doxepin may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Magnesium Citrate	Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Doxepin.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Doxepin can be increased when combined with Emapalumab.
Siponimod	Siponimod The metabolism of Siponimod can be decreased when combined with Doxepin.
Acyclovir Ophthalmic	Acyclovir Ophthalmic The metabolism of Doxepin can be decreased when combined with Acyclovir.
Erdafitinib	Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Doxepin.
Esomeprazole Injection	Esomeprazole Injection The metabolism of Doxepin can be decreased when combined with Esomeprazole.
Alpelisib	Alpelisib The serum concentration of Doxepin can be decreased when it is combined with Alpelisib.
Brexanolone Injection	Brexanolone Injection Brexanolone may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Solriamfetol	Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Doxepin.
Triclabendazole	Triclabendazole The metabolism of Doxepin can be decreased when combined with Triclabendazole.
Entrectinib	Entrectinib The risk or severity of QTc prolongation can be increased when Doxepin is combined with Entrectinib.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Doxepin.
Pitolisant	Pitolisant The therapeutic efficacy of Pitolisant can be decreased when used in combination with Doxepin.
Fedratinib	Fedratinib The metabolism of Fedratinib can be decreased when combined with Doxepin.
Lefamulin	Lefamulin Lefamulin may increase the QTc-prolonging activities of Doxepin.
Phenytoin Injection	Phenytoin Injection The metabolism of Doxepin can be decreased when combined with Phenytoin.
Fosphenytoin Injection	Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Doxepin.
Voxelotor	Voxelotor The metabolism of Voxelotor can be decreased when combined with Doxepin.
Avapritinib	Avapritinib The metabolism of Avapritinib can be decreased when combined with Doxepin.
Lumateperone	Lumateperone Lumateperone may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Lasmiditan	Lasmiditan The risk or severity of serotonin syndrome can be increased when Doxepin is combined with Lasmiditan.
Cenobamate	Cenobamate The serum concentration of Doxepin can be decreased when it is combined with Cenobamate.
Selumetinib	Selumetinib The metabolism of Selumetinib can be decreased when combined with Doxepin.
Tucatinib	Tucatinib The metabolism of Tucatinib can be decreased when combined with Doxepin.
Selpercatinib	Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Doxepin.
Capmatinib	Capmatinib The metabolism of Doxepin can be decreased when combined with Capmatinib.
Lemborexant	Lemborexant Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Fenfluramine	Fenfluramine The risk or severity of serotonin syndrome can be increased when Fenfluramine is combined with Doxepin.
Fostemsavir	Fostemsavir The risk or severity of QTc prolongation can be increased when Doxepin is combined with Fostemsavir.
Octreotide	Octreotide The risk or severity of QTc prolongation can be increased when Octreotide is combined with Doxepin.
Pralsetinib	Pralsetinib The metabolism of Doxepin can be decreased when combined with Pralsetinib.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Doxepin can be decreased when it is combined with Satralizumab.
Naxitamab-gqgk Injection	Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Doxepin is combined with Naxitamab.
Relugolix	Relugolix The risk or severity of QTc prolongation can be increased when Doxepin is combined with Relugolix.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine	Viloxazine Viloxazine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Tobramycin Injection	Tobramycin Injection Tobramycin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Theophylline	Theophylline The metabolism of Theophylline can be decreased when combined with Doxepin.
Fenoprofen	Fenoprofen Fenoprofen may decrease the excretion rate of Doxepin which could result in a higher serum level.
Indomethacin	Indomethacin The metabolism of Doxepin can be decreased when combined with Indomethacin.
Mefenamic Acid	Mefenamic Acid Mefenamic acid may decrease the excretion rate of Doxepin which could result in a higher serum level.
Naproxen	Naproxen The metabolism of Doxepin can be decreased when combined with Naproxen.
Tolmetin	Tolmetin Tolmetin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Sulindac	Sulindac Sulindac may decrease the excretion rate of Doxepin which could result in a higher serum level.
Trazodone	Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Doxepin.
Isotretinoin	Isotretinoin Isotretinoin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Sucralfate	Sucralfate Sucralfate may decrease the excretion rate of Doxepin which could result in a higher serum level.
Hydroxyurea	Hydroxyurea The metabolism of Doxepin can be decreased when combined with Hydroxyurea.
Floxuridine	Floxuridine The metabolism of Doxepin can be decreased when combined with Floxuridine.
Phenobarbital	Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Doxepin.
Metaxalone	Metaxalone Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Methotrexate Injection	Methotrexate Injection Methotrexate may decrease the excretion rate of Doxepin which could result in a higher serum level.
Levorphanol	Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Doxepin.
Primidone	Primidone The metabolism of Doxepin can be increased when combined with Primidone.
Methsuximide	Methsuximide Methsuximide may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Diethylpropion	Diethylpropion Diethylpropion may decrease the sedative and stimulatory activities of Doxepin.
Chlorpromazine	Chlorpromazine Chlorpromazine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Diazepam	Diazepam Diazepam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Oxazepam	Oxazepam Oxazepam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Flurazepam	Flurazepam Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Clorazepate	Clorazepate Clorazepic acid may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Lorazepam	Lorazepam Lorazepam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Phenoxybenzamine	Phenoxybenzamine Phenoxybenzamine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Carmustine	Carmustine The metabolism of Doxepin can be decreased when combined with Carmustine.
Amantadine	Amantadine The risk or severity of serotonin syndrome can be increased when Amantadine is combined with Doxepin.
Codeine	Codeine The risk or severity of adverse effects can be increased when Doxepin is combined with Codeine.
Meprobamate	Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Doxepin.
Chlordiazepoxide	Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Doxepin.
Bromocriptine	Bromocriptine Bromocriptine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Metaproterenol	Metaproterenol The risk or severity of hypertension can be increased when Doxepin is combined with Orciprenaline.
Tranylcypromine	Tranylcypromine The metabolism of Doxepin can be decreased when combined with Tranylcypromine.
Phenelzine	Phenelzine Phenelzine may increase the serotonergic activities of Doxepin.
Procarbazine	Procarbazine Procarbazine may increase the serotonergic activities of Doxepin.
Ergoloid Mesylates	Ergoloid Mesylates Ergoloid mesylate may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Tetracycline	Tetracycline Tetracycline may decrease the excretion rate of Doxepin which could result in a higher serum level.
Minocycline	Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Prochlorperazine	Prochlorperazine The serum concentration of Doxepin can be increased when it is combined with Prochlorperazine.
Thioridazine	Thioridazine Thioridazine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Trifluoperazine	Trifluoperazine Trifluoperazine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Bleomycin	Bleomycin Bleomycin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Dapsone	Dapsone The metabolism of Doxepin can be decreased when combined with Dapsone.
Sulfadiazine	Sulfadiazine The metabolism of Doxepin can be decreased when combined with Sulfadiazine.
Oxycodone	Oxycodone The risk or severity of adverse effects can be increased when Doxepin is combined with Oxycodone.
Methadone	Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Doxepin.
Oxybutynin	Oxybutynin Doxepin may increase the central nervous system depressant (CNS depressant) activities of Oxybutynin.
Benztropine	Benztropine Doxepin may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
Maprotiline	Maprotiline Maprotiline may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Ibuprofen	Ibuprofen Ibuprofen may decrease the excretion rate of Doxepin which could result in a higher serum level.
Trihexyphenidyl	Trihexyphenidyl Doxepin may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine	Orphenadrine Doxepin may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine	Perphenazine The serum concentration of Doxepin can be increased when it is combined with Perphenazine.
Azathioprine	Azathioprine The metabolism of Doxepin can be decreased when combined with Azathioprine.
Fluphenazine	Fluphenazine The serum concentration of Doxepin can be increased when it is combined with Fluphenazine.
Phentermine	Phentermine Phentermine may decrease the sedative and stimulatory activities of Doxepin.
Methylphenidate	Methylphenidate The therapeutic efficacy of Methylphenidate can be decreased when used in combination with Doxepin.
Amoxapine	Amoxapine Amoxapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Sulfasalazine	Sulfasalazine Sulfasalazine may decrease the excretion rate of Doxepin which could result in a higher serum level.
Doxorubicin	Doxorubicin The metabolism of Doxepin can be decreased when combined with Doxorubicin.
Mechlorethamine	Mechlorethamine The therapeutic efficacy of Doxepin can be decreased when used in combination with Mechlorethamine.
Pyridostigmine	Pyridostigmine The therapeutic efficacy of Doxepin can be decreased when used in combination with Pyridostigmine.
Phenazopyridine	Phenazopyridine Phenazopyridine may decrease the excretion rate of Doxepin which could result in a higher serum level.
Carbamazepine	Carbamazepine The metabolism of Doxepin can be increased when combined with Carbamazepine.
Molindone	Molindone The risk or severity of adverse effects can be increased when Doxepin is combined with Molindone.
Methyldopa	Methyldopa The therapeutic efficacy of Methyldopa can be decreased when used in combination with Doxepin.
Clonidine	Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Doxepin.
Prazosin	Prazosin Prazosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Hydralazine	Hydralazine Doxepin may decrease the excretion rate of Hydralazine which could result in a higher serum level.
Cimetidine	Cimetidine The metabolism of Doxepin can be decreased when combined with Cimetidine.
Gentamicin Injection	Gentamicin Injection Gentamicin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Warfarin	Warfarin The metabolism of Doxepin can be decreased when combined with Warfarin.
Clonazepam	Clonazepam Clonazepam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Loperamide	Loperamide The metabolism of Loperamide can be decreased when combined with Doxepin.
Promethazine	Promethazine The serum concentration of Doxepin can be increased when it is combined with Promethazine.
Meclofenamate	Meclofenamate Meclofenamic acid may decrease the excretion rate of Doxepin which could result in a higher serum level.
Nitrofurantoin	Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Griseofulvin	Griseofulvin The metabolism of Doxepin can be increased when combined with Griseofulvin.
Digoxin	Digoxin Digoxin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Loxapine	Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Doxepin.
Chloroquine	Chloroquine The metabolism of Doxepin can be decreased when combined with Chloroquine.
Quinine	Quinine The metabolism of Doxepin can be decreased when combined with Quinine.
Ethosuximide	Ethosuximide Ethosuximide may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Triamterene	Triamterene The metabolism of Doxepin can be decreased when combined with Triamterene.
Lactulose	Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Doxepin.
Sulfinpyrazone	Sulfinpyrazone The metabolism of Doxepin can be decreased when combined with Sulfinpyrazone.
Chlorothiazide	Chlorothiazide Doxepin may increase the excretion rate of Chlorothiazide which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone	Chlorthalidone Doxepin may increase the excretion rate of Chlorthalidone which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone	Metolazone Doxepin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide	Isosorbide Isosorbide may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy.
Clindamycin Injection	Clindamycin Injection Doxepin may increase the neurotoxic activities of Clindamycin.
Secobarbital	Secobarbital Secobarbital may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Desipramine	Desipramine The metabolism of Desipramine can be decreased when combined with Doxepin.
Amitriptyline	Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Doxepin.
Imipramine	Imipramine Imipramine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Probenecid	Probenecid The metabolism of Doxepin can be decreased when combined with Probenecid.
Quinidine	Quinidine Quinidine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Procainamide	Procainamide The metabolism of Doxepin can be decreased when combined with Procainamide.
Isoniazid	Isoniazid The metabolism of Doxepin can be decreased when combined with Isoniazid.
Pyrazinamide	Pyrazinamide Pyrazinamide may decrease the excretion rate of Doxepin which could result in a higher serum level.
Rifampin	Rifampin The metabolism of Doxepin can be increased when combined with Rifampicin.
Disopyramide	Disopyramide Doxepin may increase the central nervous system depressant (CNS depressant) activities of Disopyramide.
Valproic Acid	Valproic Acid Valproic acid may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Tamoxifen	Tamoxifen The metabolism of Doxepin can be decreased when combined with Tamoxifen.
Butabarbital	Butabarbital Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Levothyroxine	Levothyroxine The risk or severity of Cardiac Arrhythmia and CNS stimulation can be increased when Levothyroxine is combined with Doxepin.
Liothyronine	Liothyronine The risk or severity of Cardiac Arrhythmia can be increased when Liothyronine is combined with Doxepin.
Methimazole	Methimazole The risk or severity of Cardiac Arrhythmia can be increased when Methimazole is combined with Doxepin.
Propylthiouracil	Propylthiouracil The risk or severity of Cardiac Arrhythmia can be increased when Propylthiouracil is combined with Doxepin.
Chlorpropamide	Chlorpropamide Chlorpropamide may decrease the hypoglycemic activities of Doxepin.
Glucagon Injection	Glucagon Injection Doxepin may increase the gastrointestinal motility reducing activities of Glucagon.
Tolbutamide	Tolbutamide Tolbutamide may decrease the hypoglycemic activities of Doxepin.
Tolazamide	Tolazamide Tolazamide may decrease the hypoglycemic activities of Doxepin.
Dextromethorphan	Dextromethorphan Dextromethorphan may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Cyclobenzaprine	Cyclobenzaprine The risk or severity of CNS depression can be increased when Cyclobenzaprine is combined with Doxepin.
Niacin	Niacin The metabolism of Doxepin can be decreased when combined with Niacin.
Baclofen	Baclofen The risk or severity of CNS depression and hypotonia can be increased when Baclofen is combined with Doxepin.
Doxylamine	Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Cyproheptadine	Cyproheptadine Cyproheptadine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Clemastine	Clemastine Clemastine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Chlorpheniramine	Chlorpheniramine Chlorpheniramine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Brompheniramine	Brompheniramine Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Meclizine	Meclizine Meclizine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Ethambutol	Ethambutol Ethambutol may decrease the excretion rate of Doxepin which could result in a higher serum level.
Methyclothiazide	Methyclothiazide Doxepin may increase the excretion rate of Methyclothiazide which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide	Hydrochlorothiazide Doxepin may decrease the excretion rate of Hydrochlorothiazide which could result in a higher serum level.
Dantrolene	Dantrolene Dantrolene may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Chlorzoxazone	Chlorzoxazone Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Carisoprodol	Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Doxepin.
Methocarbamol	Methocarbamol Methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Pyridoxine	Pyridoxine Pyridoxine may decrease the excretion rate of Doxepin which could result in a higher serum level.
Folic Acid	Folic Acid Folic acid may decrease the excretion rate of Doxepin which could result in a higher serum level.
Disulfiram	Disulfiram The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Doxepin.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The metabolism of Doxepin can be decreased when combined with Propranolol.
Minoxidil	Minoxidil Doxepin may decrease the antihypertensive activities of Minoxidil.
Pseudoephedrine	Pseudoephedrine Pseudoephedrine may decrease the sedative and stimulatory activities of Doxepin.
Nortriptyline	Nortriptyline The serum concentration of Doxepin can be increased when it is combined with Nortriptyline.
Spironolactone	Spironolactone Spironolactone may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection	Amphotericin B Injection Amphotericin B may decrease the excretion rate of Doxepin which could result in a higher serum level.
Phytonadione	Phytonadione Phylloquinone may decrease the excretion rate of Doxepin which could result in a higher serum level.
Amikacin Injection	Amikacin Injection Amikacin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Nadolol	Nadolol The metabolism of Nadolol can be decreased when combined with Doxepin.
Butorphanol Injection	Butorphanol Injection The risk or severity of adverse effects can be increased when Butorphanol is combined with Doxepin.
Nalbuphine Injection	Nalbuphine Injection The risk or severity of adverse effects can be increased when Nalbuphine is combined with Doxepin.
Allopurinol	Allopurinol Allopurinol may decrease the excretion rate of Doxepin which could result in a higher serum level.
Oxytocin Injection	Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Doxepin.
Trimethobenzamide	Trimethobenzamide Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Flavoxate	Flavoxate Doxepin may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Papaverine	Papaverine The risk or severity of QTc prolongation can be increased when Doxepin is combined with Papaverine.
Fluorouracil Injection	Fluorouracil Injection The metabolism of Doxepin can be decreased when combined with Fluorouracil.
Colchicine	Colchicine Doxepin may decrease the excretion rate of Colchicine which could result in a higher serum level.
Cefaclor	Cefaclor Cefaclor may decrease the excretion rate of Doxepin which could result in a higher serum level.
Cefadroxil	Cefadroxil Cefadroxil may decrease the excretion rate of Doxepin which could result in a higher serum level.
Cefazolin Injection	Cefazolin Injection Cefazolin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Cephalexin	Cephalexin Cephalexin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Cefoxitin Injection	Cefoxitin Injection Cefoxitin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Dacarbazine	Dacarbazine The metabolism of Doxepin can be decreased when combined with Dacarbazine.
Acetazolamide	Acetazolamide Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Cefotaxime Injection	Cefotaxime Injection Cefotaxime may decrease the excretion rate of Doxepin which could result in a higher serum level.
Calcitonin Salmon Injection	Calcitonin Salmon Injection The risk or severity of Cardiac Arrhythmia can be increased when Salmon calcitonin is combined with Doxepin.
Ketoconazole	Ketoconazole Doxepin can cause a decrease in the absorption of Ketoconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pyrantel	Pyrantel Pyrantel may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Thiotepa Injection	Thiotepa Injection The therapeutic efficacy of Doxepin can be decreased when used in combination with Thiotepa.
Vincristine Injection	Vincristine Injection Vincristine may increase the neurotoxic activities of Doxepin.
Captopril	Captopril Doxepin may decrease the antihypertensive activities of Captopril.
Dipyridamole	Dipyridamole The risk or severity of hypotension, dyspepsia, and headache can be increased when Dipyridamole is combined with Doxepin.
Isoxsuprine	Isoxsuprine The risk or severity of hypertension can be increased when Doxepin is combined with Isoxsuprine.
Vinblastine	Vinblastine The metabolism of Doxepin can be decreased when combined with Vinblastine.
Ethacrynic Acid	Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Doxepin which could result in a higher serum level.
Colistimethate Injection	Colistimethate Injection Colistimethate may decrease the excretion rate of Doxepin which could result in a higher serum level.
Metoprolol	Metoprolol The metabolism of Doxepin can be decreased when combined with Metoprolol.
Hydroxyzine	Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Doxepin.
Thiothixene	Thiothixene The risk or severity of adverse effects can be increased when Doxepin is combined with Thiothixene.
Aspirin	Aspirin Acetylsalicylic acid may decrease the excretion rate of Doxepin which could result in a higher serum level.
Salsalate	Salsalate Doxepin may decrease the excretion rate of Salsalate which could result in a higher serum level.
Alprazolam	Alprazolam Alprazolam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Temazepam	Temazepam Temazepam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Triazolam	Triazolam Triazolam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Dicyclomine	Dicyclomine Doxepin may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine	Hyoscyamine Doxepin may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline	Propantheline Doxepin may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Trimethoprim	Trimethoprim Trimethoprim may decrease the excretion rate of Doxepin which could result in a higher serum level.
Diltiazem	Diltiazem The metabolism of Doxepin can be decreased when combined with Diltiazem.
Nifedipine	Nifedipine The metabolism of Doxepin can be decreased when combined with Nifedipine.
Timolol	Timolol The metabolism of Timolol can be decreased when combined with Doxepin.
Verapamil	Verapamil Verapamil may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Atenolol	Atenolol The metabolism of Atenolol can be decreased when combined with Doxepin.
Pindolol	Pindolol Pindolol may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Cisplatin Injection	Cisplatin Injection Cisplatin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Diflunisal	Diflunisal Diflunisal may decrease the excretion rate of Doxepin which could result in a higher serum level.
Piroxicam	Piroxicam Piroxicam may decrease the excretion rate of Doxepin which could result in a higher serum level.
Bumetanide	Bumetanide Bumetanide may decrease the excretion rate of Doxepin which could result in a higher serum level.
Streptozocin	Streptozocin The metabolism of Doxepin can be increased when combined with Streptozocin.
Etoposide	Etoposide The metabolism of Doxepin can be decreased when combined with Etoposide.
Glyburide	Glyburide The metabolism of Doxepin can be decreased when combined with Glyburide.
Glipizide	Glipizide Glipizide may decrease the hypoglycemic activities of Doxepin.
Indapamide	Indapamide Doxepin may increase the excretion rate of Indapamide which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin	Amoxicillin Amoxicillin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Nafcillin Injection	Nafcillin Injection The metabolism of Doxepin can be increased when combined with Nafcillin.
Oxacillin Injection	Oxacillin Injection Oxacillin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Pentoxifylline	Pentoxifylline The metabolism of Doxepin can be decreased when combined with Pentoxifylline.
Pentamidine Injection	Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Doxepin.
Ceftriaxone Injection	Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Doxepin which could result in a higher serum level.
Labetalol	Labetalol Labetalol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Auranofin	Auranofin Auranofin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Leuprolide Injection	Leuprolide Injection The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Doxepin.
Gemfibrozil	Gemfibrozil The metabolism of Doxepin can be decreased when combined with Gemfibrozil.
Guanabenz	Guanabenz The risk or severity of hypertension can be increased when Doxepin is combined with Guanabenz.
Dipivefrin Ophthalmic	Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Doxepin which could result in a higher serum level.
Ceftazidime Injection	Ceftazidime Injection Ceftazidime may decrease the excretion rate of Doxepin which could result in a higher serum level.
Ketoprofen	Ketoprofen Ketoprofen may decrease the excretion rate of Doxepin which could result in a higher serum level.
Cefotetan Injection	Cefotetan Injection Cefotetan may decrease the excretion rate of Doxepin which could result in a higher serum level.
Pimozide	Pimozide The metabolism of Doxepin can be decreased when combined with Pimozide.
Enalapril	Enalapril Doxepin may decrease the antihypertensive activities of Enalapril.
Flurbiprofen	Flurbiprofen Flurbiprofen may decrease the excretion rate of Doxepin which could result in a higher serum level.
Amiodarone	Amiodarone The metabolism of Doxepin can be decreased when combined with Amiodarone.
Aztreonam Injection	Aztreonam Injection Aztreonam may decrease the excretion rate of Doxepin which could result in a higher serum level.
Buspirone	Buspirone The metabolism of Buspirone can be decreased when combined with Doxepin.
Lovastatin	Lovastatin The metabolism of Doxepin can be decreased when combined with Lovastatin.
Ciprofloxacin	Ciprofloxacin The metabolism of Doxepin can be decreased when combined with Ciprofloxacin.
Mesalamine	Mesalamine The therapeutic efficacy of Mesalazine can be decreased when used in combination with Doxepin.
Diclofenac	Diclofenac The metabolism of Doxepin can be decreased when combined with Diclofenac.
Fluoxetine	Fluoxetine The serum concentration of Doxepin can be increased when it is combined with Fluoxetine.
Nimodipine	Nimodipine The risk or severity of QTc prolongation can be increased when Doxepin is combined with Nimodipine.
Interferon Alfa-2b Injection	Interferon Alfa-2b Injection The metabolism of Doxepin can be decreased when combined with Interferon alfa-2b.
Clozapine	Clozapine Clozapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Estazolam	Estazolam Estazolam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Idarubicin	Idarubicin The metabolism of Idarubicin can be decreased when combined with Doxepin.
Ofloxacin	Ofloxacin The metabolism of Doxepin can be decreased when combined with Ofloxacin.
Didanosine	Didanosine Didanosine may decrease the excretion rate of Doxepin which could result in a higher serum level.
Pentostatin Injection	Pentostatin Injection Pentostatin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Clarithromycin	Clarithromycin The risk or severity of QTc prolongation can be increased when Doxepin is combined with Clarithromycin.
Benazepril	Benazepril Doxepin may decrease the antihypertensive activities of Benazepril.
Etodolac	Etodolac Etodolac may decrease the excretion rate of Doxepin which could result in a higher serum level.
Felodipine	Felodipine The metabolism of Doxepin can be decreased when combined with Felodipine.
Fosinopril	Fosinopril Doxepin may decrease the excretion rate of Fosinopril which could result in a higher serum level.
Nabumetone	Nabumetone The metabolism of Doxepin can be decreased when combined with Nabumetone.
Quinapril	Quinapril Doxepin may decrease the antihypertensive activities of Quinapril.
Ramipril	Ramipril Doxepin may decrease the antihypertensive activities of Ramipril.
Simvastatin	Simvastatin The metabolism of Doxepin can be decreased when combined with Simvastatin.
Amlodipine	Amlodipine The risk or severity of hypotension can be increased when Amlodipine is combined with Doxepin.
Teniposide Injection	Teniposide Injection The metabolism of Doxepin can be decreased when combined with Teniposide.
Itraconazole	Itraconazole Doxepin can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lisinopril	Lisinopril Doxepin may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Oxaprozin	Oxaprozin Oxaprozin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Atovaquone	Atovaquone The metabolism of Doxepin can be decreased when combined with Atovaquone.
Rifabutin	Rifabutin The metabolism of Doxepin can be increased when combined with Rifabutin.
Sotalol	Sotalol The metabolism of Doxepin can be decreased when combined with Sotalol.
Bisoprolol	Bisoprolol Doxepin may increase the orthostatic hypotensive activities of Bisoprolol.
Zolpidem	Zolpidem Doxepin may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin	Doxazosin Doxazosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Terazosin	Terazosin Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Terazosin.
Isradipine	Isradipine The risk or severity of QTc prolongation can be increased when Doxepin is combined with Isradipine.
Omeprazole	Omeprazole The metabolism of Doxepin can be increased when combined with Omeprazole.
Cisapride	Cisapride The metabolism of Doxepin can be decreased when combined with Cisapride.
Gabapentin	Gabapentin The risk or severity of adverse effects can be increased when Gabapentin is combined with Doxepin.
Fluvastatin	Fluvastatin The metabolism of Doxepin can be decreased when combined with Fluvastatin.
Venlafaxine	Venlafaxine The metabolism of Doxepin can be decreased when combined with Venlafaxine.
Nizatidine	Nizatidine The therapeutic efficacy of Doxepin can be decreased when used in combination with Nizatidine.
Stavudine	Stavudine Stavudine may increase the neurotoxic activities of Doxepin.
Fluvoxamine	Fluvoxamine The metabolism of Doxepin can be decreased when combined with Fluvoxamine.
Nefazodone	Nefazodone Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Nefazodone.
Lamotrigine	Lamotrigine Lamotrigine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Losartan	Losartan The metabolism of Doxepin can be decreased when combined with Losartan.
Valacyclovir	Valacyclovir Valaciclovir may decrease the excretion rate of Doxepin which could result in a higher serum level.
Tramadol	Tramadol The risk or severity of serotonin syndrome can be increased when Doxepin is combined with Tramadol.
Vinorelbine Injection	Vinorelbine Injection The metabolism of Doxepin can be decreased when combined with Vinorelbine.
Carboplatin Injection	Carboplatin Injection Carboplatin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Moexipril	Moexipril The risk or severity of QTc prolongation can be increased when Moexipril is combined with Doxepin.
Lansoprazole	Lansoprazole The metabolism of Doxepin can be decreased when combined with Lansoprazole.
Ifosfamide Injection	Ifosfamide Injection Doxepin may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Nicardipine	Nicardipine Nicardipine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Bupropion	Bupropion The risk or severity of seizure can be increased when Doxepin is combined with Bupropion.
Ticlopidine	Ticlopidine The metabolism of Doxepin can be decreased when combined with Ticlopidine.
Saquinavir	Saquinavir Doxepin can cause an increase in the absorption of Saquinavir resulting in an increased serum concentration and potentially a worsening of adverse effects.
Metformin	Metformin Doxepin may decrease the hypoglycemic activities of Metformin.
Nisoldipine	Nisoldipine The risk or severity of hypotension can be increased when Doxepin is combined with Nisoldipine.
Lamivudine	Lamivudine Lamivudine may decrease the excretion rate of Doxepin which could result in a higher serum level.
Riluzole	Riluzole Riluzole may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Acarbose	Acarbose Doxepin may decrease the hypoglycemic activities of Acarbose.
Glimepiride	Glimepiride Glimepiride may decrease the hypoglycemic activities of Doxepin.
Gemcitabine Injection	Gemcitabine Injection Gemcitabine may decrease the excretion rate of Doxepin which could result in a higher serum level.
Indinavir	Indinavir Doxepin can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ritonavir	Ritonavir The serum concentration of Doxepin can be increased when it is combined with Ritonavir.
Cidofovir Injection	Cidofovir Injection Cidofovir may decrease the excretion rate of Doxepin which could result in a higher serum level.
Meropenem Injection	Meropenem Injection Meropenem may decrease the excretion rate of Doxepin which could result in a higher serum level.
Clomipramine	Clomipramine The metabolism of Doxepin can be decreased when combined with Clomipramine.
Zafirlukast	Zafirlukast The metabolism of Doxepin can be decreased when combined with Zafirlukast.
Fosfomycin	Fosfomycin Fosfomycin may decrease the excretion rate of Doxepin which could result in a higher serum level.
Mirtazapine	Mirtazapine Doxepin may increase the serotonergic activities of Mirtazapine.
Trandolapril	Trandolapril Doxepin may decrease the antihypertensive activities of Trandolapril.
Topiramate	Topiramate The risk or severity of hyperthermia and oligohydrosis can be increased when Doxepin is combined with Topiramate.
Zileuton	Zileuton The metabolism of Doxepin can be decreased when combined with Zileuton.
Valsartan	Valsartan The metabolism of Doxepin can be decreased when combined with Valsartan.
Insulin Lispro Injection	Insulin Lispro Injection The metabolism of Doxepin can be increased when combined with Insulin lispro.
Pramipexole	Pramipexole Doxepin may increase the sedative activities of Pramipexole.
Donepezil	Donepezil The therapeutic efficacy of Doxepin can be decreased when used in combination with Donepezil.
Nelfinavir	Nelfinavir Doxepin can cause a decrease in the absorption of Nelfinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Azithromycin	Azithromycin The risk or severity of QTc prolongation can be increased when Doxepin is combined with Azithromycin.
Loratadine	Loratadine Doxepin may increase the anticholinergic activities of Loratadine.
Carvedilol	Carvedilol Carvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Doxepin.
Nilutamide	Nilutamide The metabolism of Doxepin can be decreased when combined with Nilutamide.
Flutamide	Flutamide The metabolism of Doxepin can be decreased when combined with Flutamide.
Selegiline	Selegiline Selegiline may increase the serotonergic activities of Doxepin.
Bicalutamide	Bicalutamide The metabolism of Doxepin can be decreased when combined with Bicalutamide.
Sertraline	Sertraline The metabolism of Doxepin can be decreased when combined with Sertraline.
Propafenone	Propafenone The metabolism of Doxepin can be decreased when combined with Propafenone.
Letrozole	Letrozole The metabolism of Doxepin can be decreased when combined with Letrozole.
Irbesartan	Irbesartan The metabolism of Doxepin can be decreased when combined with Irbesartan.
Tamsulosin	Tamsulosin Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Tamsulosin.
Ropinirole	Ropinirole Doxepin may increase the sedative activities of Ropinirole.
Finasteride	Finasteride The risk or severity of hypertension can be increased when Doxepin is combined with Finasteride.
Quetiapine	Quetiapine Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Quetiapine.
Cefepime Injection	Cefepime Injection Cefepime may decrease the excretion rate of Doxepin which could result in a higher serum level.
Cefprozil	Cefprozil Cefprozil may decrease the excretion rate of Doxepin which could result in a higher serum level.
Cefpodoxime	Cefpodoxime Doxepin can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cetirizine	Cetirizine Cetirizine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Paroxetine	Paroxetine The metabolism of Doxepin can be decreased when combined with Paroxetine.
Tolcapone	Tolcapone The metabolism of Doxepin can be decreased when combined with Tolcapone.
Citalopram	Citalopram The risk or severity of adverse effects can be increased when Doxepin is combined with Citalopram.
Capecitabine	Capecitabine The metabolism of Doxepin can be decreased when combined with Capecitabine.
Efavirenz	Efavirenz The metabolism of Doxepin can be decreased when combined with Efavirenz.
Abacavir	Abacavir Abacavir may decrease the excretion rate of Doxepin which could result in a higher serum level.
Sildenafil	Sildenafil The metabolism of Doxepin can be decreased when combined with Sildenafil.
Pioglitazone	Pioglitazone Doxepin may decrease the hypoglycemic activities of Pioglitazone.
Celecoxib	Celecoxib The metabolism of Doxepin can be decreased when combined with Celecoxib.
Rosiglitazone	Rosiglitazone The metabolism of Doxepin can be decreased when combined with Rosiglitazone.
Tolterodine	Tolterodine Tolterodine may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Thalidomide	Thalidomide Doxepin may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir	Oseltamivir Oseltamivir may decrease the excretion rate of Doxepin which could result in a higher serum level.
Balsalazide	Balsalazide Balsalazide may decrease the excretion rate of Doxepin which could result in a higher serum level.
Nateglinide	Nateglinide The metabolism of Doxepin can be decreased when combined with Nateglinide.
Galantamine	Galantamine The risk or severity of QTc prolongation can be increased when Doxepin is combined with Galantamine.
Levetiracetam	Levetiracetam Levetiracetam may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Rabeprazole	Rabeprazole The metabolism of Doxepin can be decreased when combined with Rabeprazole.
Terbinafine	Terbinafine The metabolism of Doxepin can be decreased when combined with Terbinafine.