Sitagliptin

Generic name: Pronounced as (sit a glip' tin)
Brand names
  • Januvia®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 02/15/2021

Sitagliptin is used along with diet and exercise and sometimes with other medications to lower blood sugar levels in adults with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally). Sitagliptin is in a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by increasing the amounts of certain natural substances that lower blood sugar when it is high. Sitagliptin is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood).

Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

Sitagliptin comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take sitagliptin at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sitagliptin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Sitagliptin helps to control high blood sugar but does not cure diabetes. Continue to take sitagliptin even if you feel well. Do not stop taking sitagliptin without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking sitagliptin,

  • tell your doctor and pharmacist if you are allergic to sitagliptin or any other medications.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: digoxin (Lanoxicaps, Lanoxin); insulin; and certain oral medications for diabetes including acetohexamide, chlorpropamide (Diabinese), glimepiride (Amaryl), glipizide (Glucotrol, in Metaglip), glyburide (Diabeta, Glycron, Micronase), tolazamide (Tolinase), and tolbutamide. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you drink or have ever drunk large amounts of alcohol and if you have or have ever had diabetic ketoacidosis (a serious condition that may occur when blood sugar is too high), pancreatitis (swelling of the pancreas), gallstones, high levels of triglycerides (fatty substances) in your blood, heart failure, or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking sitagliptin, call your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking sitagliptin.

  • talk to your doctor about what you should do if you get hurt or if you develop a fever or infection. These conditions may affect your blood sugar.

  • talk to your doctor about the symptoms of high and low blood sugar and other complications of diabetes, what to do if you develop these symptoms, and how to prevent these conditions.

Be sure to follow all diet and exercise recommendations made by your doctor or dietician.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Sitagliptin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • stuffed or runny nose

    • sore throat

    • headache

    • diarrhea

    • nausea

  • Some side effects can be serious. If you experience any of these symptoms, stop taking sitagliptin and call your doctor immediately:

    • fever, nausea, vomiting, loss of appetite, ongoing pain that begins in the upper left or middle of the stomach but may spread to the back

    • shortness of breath, rapid weight gain, or swelling of feet or ankles

    • itchy skin, skin blistering or peeling

    • joint pain

    • rash

    • hives

    • swelling of the face, lips, tongue, and throat

    • difficulty in breathing or swallowing

  • Sitagliptin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests before and during your treatment with sitagliptin. Your blood sugar and glycosylated hemoglobin (HbA1c) should be checked regularly to determine your response to sitagliptin. Your doctor will also tell you how to check your response to sitagliptin by measuring your blood or urine sugar levels at home. Follow these instructions carefully.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Janumet® (containing Metformin, Sitagliptin)
  • Juvisync® (containing Simvastatin, Sitagliptin)
  • Steglujan® (containing Ertugliflozin, Sitagliptin)

Drug Interaction
Moxifloxacin Moxifloxacin The therapeutic efficacy of Sitagliptin can be increased when used in combination with Moxifloxacin.
Repaglinide Repaglinide The metabolism of Sitagliptin can be decreased when combined with Repaglinide.
Montelukast Montelukast The metabolism of Sitagliptin can be decreased when combined with Montelukast.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection Sitagliptin may increase the hypoglycemic activities of Insulin glargine.
Atorvastatin Atorvastatin The metabolism of Sitagliptin can be decreased when combined with Atorvastatin.
Candesartan Candesartan The metabolism of Sitagliptin can be decreased when combined with Candesartan.
Cilostazol Cilostazol Cilostazol may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Clopidogrel Clopidogrel The metabolism of Sitagliptin can be decreased when combined with Clopidogrel.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The serum concentration of Sitagliptin can be increased when it is combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The risk or severity of angioedema can be increased when Conjugated estrogens is combined with Sitagliptin.
Fenofibrate Fenofibrate Fenofibrate may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Guanfacine Guanfacine Guanfacine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Magnesium Hydroxide Magnesium Hydroxide Sitagliptin may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Miglitol Miglitol The risk or severity of hypoglycemia can be increased when Miglitol is combined with Sitagliptin.
Mycophenolate Mycophenolate Mycophenolic acid may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Olsalazine Olsalazine Olsalazine may increase the hypoglycemic activities of Sitagliptin.
Paregoric Paregoric The metabolism of Sitagliptin can be decreased when combined with Morphine.
Penbutolol Penbutolol The therapeutic efficacy of Sitagliptin can be increased when used in combination with Acebutolol.
Potassium Potassium Potassium may increase the excretion rate of Sitagliptin which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone The risk or severity of hyperglycemia can be increased when Prednisone is combined with Sitagliptin.
Ranitidine Ranitidine Ranitidine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Reserpine Reserpine The serum concentration of Sitagliptin can be increased when it is combined with Reserpine.
Rizatriptan Rizatriptan Rizatriptan may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Sumatriptan Sumatriptan The therapeutic efficacy of Sitagliptin can be increased when used in combination with Sumatriptan.
Tacrolimus Tacrolimus The serum concentration of Sitagliptin can be increased when it is combined with Tacrolimus.
Triamcinolone Triamcinolone The risk or severity of hyperglycemia can be increased when Triamcinolone is combined with Sitagliptin.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Famotidine Injection Famotidine Injection The excretion of Sitagliptin can be decreased when combined with Famotidine.
Fluconazole Injection Fluconazole Injection The risk or severity of hypoglycemia can be increased when Sitagliptin is combined with Fluconazole.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection Hydromorphone may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Levofloxacin Injection Levofloxacin Injection The therapeutic efficacy of Sitagliptin can be increased when used in combination with Levofloxacin.
Meperidine Injection Meperidine Injection Meperidine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Methylprednisolone Injection Methylprednisolone Injection The risk or severity of hyperglycemia can be increased when Methylprednisolone is combined with Sitagliptin.
Metoclopramide Injection Metoclopramide Injection Metoclopramide may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Metronidazole Injection Metronidazole Injection The metabolism of Sitagliptin can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The metabolism of Sitagliptin can be decreased when combined with Morphine.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Sitagliptin may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The metabolism of Sitagliptin can be decreased when combined with Zidovudine.
Altretamine Altretamine Amphetamine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Cyclosporine Cyclosporine The serum concentration of Cyclosporine can be increased when it is combined with Sitagliptin.
Torsemide Torsemide The therapeutic efficacy of Sitagliptin can be increased when used in combination with Torasemide.
Olanzapine Olanzapine The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Olanzapine.
Eprosartan Eprosartan The risk or severity of angioedema can be increased when Eprosartan is combined with Sitagliptin.
Hydroxychloroquine Hydroxychloroquine The therapeutic efficacy of Sitagliptin can be increased when used in combination with Hydroxychloroquine.
Meloxicam Meloxicam Meloxicam may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Pantoprazole Pantoprazole The excretion of Sitagliptin can be decreased when combined with Pantoprazole.
Telmisartan Telmisartan The risk or severity of angioedema can be increased when Telmisartan is combined with Sitagliptin.
Temozolomide Temozolomide Temozolomide may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Zaleplon Zaleplon Zaleplon may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Anakinra Anakinra The metabolism of Sitagliptin can be increased when combined with Anakinra.
Linezolid Linezolid Linezolid may increase the hypoglycemic activities of Sitagliptin.
Trimipramine Trimipramine Trimipramine may decrease the hypoglycemic activities of Sitagliptin.
Etanercept Injection Etanercept Injection The metabolism of Sitagliptin can be increased when combined with Etanercept.
Perindopril Perindopril The risk or severity of angioedema can be increased when Perindopril is combined with Sitagliptin.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Sirolimus Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Sitagliptin.
Epinephrine Injection Epinephrine Injection The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Epinephrine.
Eplerenone Eplerenone Eplerenone may increase the excretion rate of Sitagliptin which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram Escitalopram The risk or severity of hypoglycemia can be increased when Escitalopram is combined with Sitagliptin.
Zonisamide Zonisamide The therapeutic efficacy of Sitagliptin can be increased when used in combination with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Sitagliptin can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Aripiprazole.
Atomoxetine Atomoxetine Atomoxetine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Atazanavir Atazanavir The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Atazanavir.
Almotriptan Almotriptan The metabolism of Sitagliptin can be decreased when combined with Almotriptan.
Rosuvastatin Rosuvastatin The therapeutic efficacy of Sitagliptin can be increased when used in combination with Rosuvastatin.
Vardenafil Vardenafil The serum concentration of Vardenafil can be increased when it is combined with Sitagliptin.
Emtricitabine Emtricitabine Emtricitabine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Memantine Memantine Memantine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Tegaserod Tegaserod The serum concentration of Sitagliptin can be increased when it is combined with Tegaserod.
Tadalafil Tadalafil Tadalafil may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Fosamprenavir Fosamprenavir The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Fosamprenavir.
Gemifloxacin Gemifloxacin The therapeutic efficacy of Sitagliptin can be increased when used in combination with Gemifloxacin.
Progesterone Progesterone The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Progesterone.
Apomorphine Injection Apomorphine Injection The metabolism of Sitagliptin can be decreased when combined with Apomorphine.
Infliximab Injection Infliximab Injection The metabolism of Sitagliptin can be increased when combined with Infliximab.
Oxandrolone Oxandrolone Oxandrolone may increase the hypoglycemic activities of Sitagliptin.
Protriptyline Protriptyline Protriptyline may decrease the hypoglycemic activities of Sitagliptin.
Rifaximin Rifaximin The metabolism of Sitagliptin can be increased when combined with Rifaximin.
Duloxetine Duloxetine The risk or severity of hypoglycemia can be increased when Duloxetine is combined with Sitagliptin.
Norethindrone Norethindrone The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Norethisterone.
Tinidazole Tinidazole Tinidazole may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Bosentan Bosentan The therapeutic efficacy of Sitagliptin can be increased when used in combination with Bosentan.
Cefditoren Cefditoren Cefdinir may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Erlotinib Erlotinib The metabolism of Sitagliptin can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The metabolism of Sitagliptin can be decreased when combined with Eszopiclone.
Ganciclovir Ganciclovir The excretion of Sitagliptin can be decreased when combined with Ganciclovir.
Insulin Aspart (rDNA Origin) Injection Insulin Aspart (rDNA Origin) Injection Sitagliptin may increase the hypoglycemic activities of Insulin aspart.
Ribavirin Ribavirin Ribavirin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Valganciclovir Valganciclovir Sitagliptin may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Adefovir Adefovir Adefovir may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Amphetamine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Pramlintide Injection Pramlintide Injection The risk or severity of hypoglycemia can be increased when Sitagliptin is combined with Pramlintide.
Exenatide Injection Exenatide Injection The risk or severity of hypoglycemia can be increased when Sitagliptin is combined with Exenatide.
Isocarboxazid Isocarboxazid Isocarboxazid may increase the hypoglycemic activities of Sitagliptin.
Ramelteon Ramelteon Ramelteon may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Fentanyl Fentanyl Fentanyl may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Pregabalin Pregabalin The risk or severity of angioedema can be increased when Pregabalin is combined with Sitagliptin.
Deferasirox Deferasirox The metabolism of Sitagliptin can be decreased when combined with Deferasirox.
Tipranavir Tipranavir The serum concentration of Tipranavir can be increased when it is combined with Sitagliptin.
Insulin Detemir (rDNA Origin) Injection Insulin Detemir (rDNA Origin) Injection Sitagliptin may increase the hypoglycemic activities of Insulin detemir.
Ranolazine Ranolazine The serum concentration of Sitagliptin can be increased when it is combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Sitagliptin can be increased when combined with Abatacept.
Rasagiline Rasagiline Sitagliptin may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Imatinib Imatinib The metabolism of Sitagliptin can be decreased when combined with Imatinib.
Varenicline Varenicline Sitagliptin may decrease the excretion rate of Varenicline which could result in a higher serum level.
Albuterol Albuterol Salbutamol may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Paliperidone Paliperidone The serum concentration of Sitagliptin can be increased when it is combined with Paliperidone.
Bortezomib Bortezomib The serum concentration of Bortezomib can be increased when it is combined with Sitagliptin.
Clofarabine Injection Clofarabine Injection Clofarabine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection Sitagliptin may increase the hypoglycemic activities of Insulin glulisine.
Lubiprostone Lubiprostone Lubiprostone may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Posaconazole Posaconazole The serum concentration of Posaconazole can be increased when it is combined with Sitagliptin.
Bismuth Subsalicylate Bismuth Subsalicylate Bismuth subsalicylate may increase the hypoglycemic activities of Sitagliptin.
Darunavir Darunavir The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Darunavir.
Pemetrexed Injection Pemetrexed Injection Sitagliptin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Nabilone Nabilone The metabolism of Sitagliptin can be decreased when combined with Nabilone.
Vorinostat Vorinostat The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Vorinostat.
Sorafenib Sorafenib The metabolism of Sitagliptin can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The risk or severity of hypoglycemia can be increased when Sitagliptin is combined with Sunitinib.
Lapatinib Lapatinib The serum concentration of Sitagliptin can be increased when it is combined with Lapatinib.
Levocetirizine Levocetirizine Sitagliptin may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Sitagliptin may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib Dasatinib The serum concentration of Dasatinib can be increased when it is combined with Sitagliptin.
Azacitidine Injection Azacitidine Injection Azacitidine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Temsirolimus Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Sitagliptin.
Lenalidomide Lenalidomide Lenalidomide may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Nilotinib Nilotinib The serum concentration of Sitagliptin can be increased when it is combined with Nilotinib.
Toremifene Toremifene The serum concentration of Sitagliptin can be increased when it is combined with Toremifene.
Bexarotene Bexarotene The metabolism of Sitagliptin can be decreased when combined with Bexarotene.
Budesonide Budesonide The risk or severity of hyperglycemia can be increased when Budesonide is combined with Sitagliptin.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Doripenem Injection Doripenem Injection Sitagliptin may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection Arsenic Trioxide Injection The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Arsenic trioxide.
Desvenlafaxine Desvenlafaxine The risk or severity of hypoglycemia can be increased when Sitagliptin is combined with Desvenlafaxine.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Nebivolol Nebivolol The therapeutic efficacy of Nebivolol can be increased when used in combination with Sitagliptin.
Tretinoin Tretinoin The metabolism of Sitagliptin can be decreased when combined with Tretinoin.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Sitagliptin.
Leucovorin Injection Leucovorin Injection The excretion of Sitagliptin can be decreased when combined with Leucovorin.
Certolizumab Injection Certolizumab Injection The metabolism of Sitagliptin can be increased when combined with Certolizumab pegol.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Methylnaltrexone Injection Methylnaltrexone Injection Sitagliptin may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Silodosin Silodosin The serum concentration of Silodosin can be increased when it is combined with Sitagliptin.
Midazolam Midazolam Midazolam may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Dexrazoxane Injection Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Eltrombopag Eltrombopag The metabolism of Sitagliptin can be decreased when combined with Eltrombopag.
Milnacipran Milnacipran The risk or severity of hypoglycemia can be increased when Sitagliptin is combined with Milnacipran.
Plerixafor Injection Plerixafor Injection Sitagliptin may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine Fesoterodine Sitagliptin may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Betaxolol Betaxolol The therapeutic efficacy of Sitagliptin can be increased when used in combination with Betaxolol.
Iloperidone Iloperidone The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Iloperidone.
Prasugrel Prasugrel Sitagliptin may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Everolimus Everolimus The serum concentration of Everolimus can be increased when it is combined with Sitagliptin.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Sitagliptin.
Dronedarone Dronedarone The serum concentration of Dronedarone can be increased when it is combined with Sitagliptin.
Pralatrexate Injection Pralatrexate Injection Sitagliptin may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection Palonosetron may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Saxagliptin Saxagliptin The risk or severity of angioedema can be increased when Sitagliptin is combined with Saxagliptin.
Telavancin Injection Telavancin Injection Sitagliptin may decrease the excretion rate of Telavancin which could result in a higher serum level.
Romidepsin Injection Romidepsin Injection The serum concentration of Romidepsin can be increased when it is combined with Sitagliptin.
Topotecan Topotecan The serum concentration of Sitagliptin can be increased when it is combined with Topotecan.
Golimumab Injection Golimumab Injection The metabolism of Sitagliptin can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Sitagliptin.
Asenapine Asenapine The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Asenapine.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Sitagliptin.
Levonorgestrel Levonorgestrel The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Levonorgestrel.
Liraglutide Injection Liraglutide Injection The risk or severity of hypoglycemia can be increased when Sitagliptin is combined with Liraglutide.
Tocilizumab Injection Tocilizumab Injection The metabolism of Sitagliptin can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine Sitagliptin may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Sitagliptin.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Lurasidone Lurasidone The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Lurasidone.
Acetaminophen Injection Acetaminophen Injection Acetaminophen may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Ipilimumab Injection Ipilimumab Injection Sitagliptin may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Terbutaline may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Azilsartan Azilsartan The risk or severity of angioedema can be increased when Sitagliptin is combined with Azilsartan medoxomil.
Roflumilast Roflumilast Sitagliptin may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Linagliptin Linagliptin The serum concentration of Sitagliptin can be increased when it is combined with Linagliptin.
Telaprevir Telaprevir The serum concentration of Sitagliptin can be increased when it is combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Sitagliptin can be increased when combined with Cyclophosphamide.
Abiraterone Abiraterone The metabolism of Sitagliptin can be decreased when combined with Abiraterone.
Triptorelin Injection Triptorelin Injection The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Triptorelin.
Rivaroxaban Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Sitagliptin.
Ticagrelor Ticagrelor The serum concentration of Ticagrelor can be increased when it is combined with Sitagliptin.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Sitagliptin.
Ruxolitinib Ruxolitinib Sitagliptin may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Vandetanib Vandetanib The serum concentration of Sitagliptin can be increased when it is combined with Vandetanib.
Clobazam Clobazam The serum concentration of Sitagliptin can be increased when it is combined with Clobazam.
Vemurafenib Vemurafenib The serum concentration of Sitagliptin can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Sitagliptin can be decreased when combined with Vismodegib.
Ivacaftor Ivacaftor The serum concentration of Sitagliptin can be increased when it is combined with Ivacaftor.
Deferiprone Deferiprone Sitagliptin may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib Axitinib The serum concentration of Axitinib can be increased when it is combined with Sitagliptin.
Crizotinib Crizotinib The serum concentration of Sitagliptin can be increased when it is combined with Crizotinib.
Cabergoline Cabergoline The serum concentration of Cabergoline can be increased when it is combined with Sitagliptin.
Naloxone Injection Naloxone Injection Naloxone may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Ambrisentan Ambrisentan The serum concentration of Ambrisentan can be increased when it is combined with Sitagliptin.
Fondaparinux Injection Fondaparinux Injection Fondaparinux may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Sitagliptin can be increased when it is combined with Carfilzomib.
Enzalutamide Enzalutamide The serum concentration of Sitagliptin can be increased when it is combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Sitagliptin.
Regorafenib Regorafenib The serum concentration of Sitagliptin can be increased when it is combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Sitagliptin can be decreased when combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The risk or severity of hyperglycemia can be increased when Corticotropin is combined with Sitagliptin.
Teriflunomide Teriflunomide The metabolism of Sitagliptin can be decreased when combined with Teriflunomide.
Lorcaserin Lorcaserin The risk or severity of hypoglycemia can be increased when Sitagliptin is combined with Mecasermin.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Sitagliptin can be decreased when combined with Cabozantinib.
Teduglutide Injection Teduglutide Injection Sitagliptin may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Alogliptin Alogliptin The risk or severity of angioedema can be increased when Sitagliptin is combined with Alogliptin.
Ponatinib Ponatinib The metabolism of Sitagliptin can be decreased when combined with Ponatinib.
Pomalidomide Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Sitagliptin.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be increased when it is combined with Sitagliptin.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Sitagliptin.
Canagliflozin Canagliflozin The serum concentration of Sitagliptin can be increased when it is combined with Canagliflozin.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Sitagliptin which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib Dabrafenib The metabolism of Sitagliptin can be decreased when combined with Dabrafenib.
Trametinib Trametinib The metabolism of Sitagliptin can be decreased when combined with Trametinib.
Dolutegravir Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Sitagliptin.
Afatinib Afatinib The serum concentration of Sitagliptin can be increased when it is combined with Afatinib.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Sitagliptin.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Sitagliptin.
Lomitapide Lomitapide The serum concentration of Lomitapide can be increased when it is combined with Sitagliptin.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Simeprevir Simeprevir The serum concentration of Sitagliptin can be increased when it is combined with Simeprevir.
Sofosbuvir Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Sitagliptin.
Dapagliflozin Dapagliflozin Dapagliflozin may increase the hypoglycemic activities of Sitagliptin.
Apremilast Apremilast The metabolism of Sitagliptin can be increased when combined with Apremilast.
Droxidopa Droxidopa Sitagliptin may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib Ceritinib The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Ceritinib.
Siltuximab Injection Siltuximab Injection The metabolism of Sitagliptin can be increased when combined with Siltuximab.
Albiglutide Injection Albiglutide Injection The risk or severity of hypoglycemia can be increased when Sitagliptin is combined with Albiglutide.
Belinostat Injection Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Sitagliptin.
Idelalisib Idelalisib The serum concentration of Idelalisib can be increased when it is combined with Sitagliptin.
Testosterone Injection Testosterone Injection Testosterone may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Empagliflozin Empagliflozin The risk or severity of hypoglycemia can be increased when Sitagliptin is combined with Empagliflozin.
Vorapaxar Vorapaxar The serum concentration of Sitagliptin can be increased when it is combined with Vorapaxar.
Suvorexant Suvorexant The serum concentration of Sitagliptin can be increased when it is combined with Suvorexant.
Dulaglutide Injection Dulaglutide Injection The risk or severity of hypoglycemia can be increased when Sitagliptin is combined with Dulaglutide.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Sitagliptin.
Methamphetamine Methamphetamine Sitagliptin may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Tasimelteon Tasimelteon Sitagliptin may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Riociguat Riociguat The metabolism of Riociguat can be decreased when combined with Sitagliptin.
Lanreotide Injection Lanreotide Injection The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Lanreotide.
Nintedanib Nintedanib The serum concentration of Nintedanib can be increased when it is combined with Sitagliptin.
Secukinumab Injection Secukinumab Injection The metabolism of Sitagliptin can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Risperidone.
Palbociclib Palbociclib The serum concentration of Sitagliptin can be increased when it is combined with Palbociclib.
Insulin Human Inhalation Insulin Human Inhalation Sitagliptin may increase the hypoglycemic activities of Insulin human.
Lenvatinib Lenvatinib The metabolism of Sitagliptin can be decreased when combined with Lenvatinib.
Panobinostat Panobinostat The serum concentration of Panobinostat can be increased when it is combined with Sitagliptin.
Haloperidol Injection Haloperidol Injection The serum concentration of Sitagliptin can be increased when it is combined with Haloperidol.
Amiloride Amiloride Amiloride may increase the excretion rate of Sitagliptin which could result in a lower serum level and potentially a reduction in efficacy.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Sitagliptin can be increased when it is combined with Isavuconazonium.
Macitentan Macitentan Sitagliptin may decrease the excretion rate of Macitentan which could result in a higher serum level.
Flibanserin Flibanserin The serum concentration of Sitagliptin can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant The serum concentration of Sitagliptin can be increased when it is combined with Rolapitant.
Prednisolone Prednisolone The risk or severity of hyperglycemia can be increased when Prednisolone is combined with Sitagliptin.
Daclatasvir Daclatasvir The serum concentration of Sitagliptin can be increased when it is combined with Daclatasvir.
Brexpiprazole Brexpiprazole The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Ziprasidone.
Penicillin G Procaine Injection Penicillin G Procaine Injection Sitagliptin may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection Sitagliptin may increase the hypoglycemic activities of Insulin degludec.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Sitagliptin.
Osimertinib Osimertinib The serum concentration of Osimertinib can be increased when it is combined with Sitagliptin.
Ixazomib Ixazomib Sitagliptin may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Rifapentine Rifapentine The metabolism of Sitagliptin can be increased when combined with Rifapentine.
Lesinurad Lesinurad Sitagliptin may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection The risk or severity of hyperglycemia can be increased when Dexamethasone is combined with Sitagliptin.
Brivaracetam Injection Brivaracetam Injection Sitagliptin may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
Venetoclax Venetoclax The serum concentration of Sitagliptin can be increased when it is combined with Venetoclax.
Cobicistat Cobicistat The serum concentration of Sitagliptin can be increased when it is combined with Cobicistat.
Selexipag Selexipag The metabolism of Selexipag can be decreased when combined with Sitagliptin.
Furosemide Injection Furosemide Injection The therapeutic efficacy of Sitagliptin can be increased when used in combination with Furosemide.
Rucaparib Rucaparib The serum concentration of Sitagliptin can be increased when it is combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection The risk or severity of hypoglycemia can be increased when Sitagliptin is combined with Lixisenatide.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Sitagliptin.
Doxepin (Insomnia) Doxepin (Insomnia) Doxepin may decrease the hypoglycemic activities of Sitagliptin.
Deutetrabenazine Deutetrabenazine Sitagliptin may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Sitagliptin may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort Deflazacort The risk or severity of hyperglycemia can be increased when Deflazacort is combined with Sitagliptin.
Safinamide Safinamide Safinamide may increase the hypoglycemic activities of Sitagliptin.
Naldemedine Naldemedine Sitagliptin may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Midostaurin Midostaurin The metabolism of Sitagliptin can be decreased when combined with Midostaurin.
Neratinib Neratinib The serum concentration of Sitagliptin can be increased when it is combined with Neratinib.
Enasidenib Enasidenib The metabolism of Sitagliptin can be decreased when combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Sitagliptin.
Benznidazole Benznidazole Sitagliptin may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection Copanlisib Injection The serum concentration of Copanlisib can be increased when it is combined with Sitagliptin.
Delafloxacin Delafloxacin The therapeutic efficacy of Sitagliptin can be increased when used in combination with Delafloxacin.
Abemaciclib Abemaciclib The serum concentration of Abemaciclib can be increased when it is combined with Sitagliptin.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Sitagliptin.
Letermovir Letermovir The excretion of Sitagliptin can be decreased when combined with Letermovir.
Semaglutide Injection Semaglutide Injection The risk or severity of hypoglycemia can be increased when Sitagliptin is combined with Semaglutide.
Buprenorphine Injection Buprenorphine Injection The metabolism of Sitagliptin can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The serum concentration of Sitagliptin can be decreased when it is combined with Apalutamide.
Avatrombopag Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Sitagliptin.
Baricitinib Baricitinib The serum concentration of Baricitinib can be increased when it is combined with Sitagliptin.
Lofexidine Lofexidine Sitagliptin may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Plazomicin Injection Plazomicin Injection Sitagliptin may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat Eliglustat The serum concentration of Eliglustat can be increased when it is combined with Sitagliptin.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Sitagliptin.
Ivosidenib Ivosidenib The serum concentration of Sitagliptin can be increased when it is combined with Ivosidenib.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Sitagliptin.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Sitagliptin.
Dacomitinib Dacomitinib The serum concentration of Sitagliptin can be increased when it is combined with Dacomitinib.
Duvelisib Duvelisib The serum concentration of Duvelisib can be increased when it is combined with Sitagliptin.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Sitagliptin.
Sarecycline Sarecycline The serum concentration of Sitagliptin can be increased when it is combined with Sarecycline.
Stiripentol Stiripentol Sitagliptin may decrease the excretion rate of Stiripentol which could result in a higher serum level.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Sitagliptin.
Gilteritinib Gilteritinib The serum concentration of Gilteritinib can be increased when it is combined with Sitagliptin.
Glasdegib Glasdegib The serum concentration of Sitagliptin can be increased when it is combined with Glasdegib.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Sitagliptin.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Sitagliptin.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Sitagliptin.
Rifamycin Rifamycin The serum concentration of Sitagliptin can be increased when it is combined with Rifamycin.
Prucalopride Prucalopride Sitagliptin may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Sitagliptin can be increased when combined with Emapalumab.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Erdafitinib Erdafitinib The serum concentration of Sitagliptin can be increased when it is combined with Erdafitinib.
Esomeprazole Injection Esomeprazole Injection The excretion of Sitagliptin can be decreased when combined with Esomeprazole.
Alpelisib Alpelisib The metabolism of Sitagliptin can be decreased when combined with Alpelisib.
Solriamfetol Solriamfetol Sitagliptin may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Sitagliptin.
Triclabendazole Triclabendazole The metabolism of Sitagliptin can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The serum concentration of Sitagliptin can be increased when it is combined with Entrectinib.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Sitagliptin.
Pitolisant Pitolisant The serum concentration of Sitagliptin can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Sitagliptin can be increased when it is combined with Fedratinib.
Lefamulin Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Sitagliptin.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Sitagliptin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Sitagliptin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Sitagliptin.
Lasmiditan Lasmiditan The serum concentration of Sitagliptin can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Sitagliptin.
Tazemetostat Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Sitagliptin.
Cenobamate Cenobamate The serum concentration of Sitagliptin can be decreased when it is combined with Cenobamate.
Teprotumumab-trbw Injection Teprotumumab-trbw Injection The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Teprotumumab.
Ozanimod Ozanimod The metabolism of Ozanimod can be decreased when combined with Sitagliptin.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Sitagliptin.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Sitagliptin.
Tucatinib Tucatinib Sitagliptin may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Sitagliptin.
Ripretinib Ripretinib The serum concentration of Sitagliptin can be increased when it is combined with Ripretinib.
Selpercatinib Selpercatinib The serum concentration of Sitagliptin can be increased when it is combined with Selpercatinib.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Sitagliptin.
Fostemsavir Fostemsavir The serum concentration of Fostemsavir can be increased when it is combined with Sitagliptin.
Octreotide Octreotide The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Octreotide.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Sitagliptin.
Pralsetinib Pralsetinib The serum concentration of Sitagliptin can be increased when it is combined with Pralsetinib.
Opicapone Opicapone The metabolism of Sitagliptin can be decreased when combined with Opicapone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Sitagliptin can be decreased when it is combined with Satralizumab.
Cabotegravir Cabotegravir The excretion of Sitagliptin can be decreased when combined with Cabotegravir.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Drospirenone.
Viloxazine Viloxazine Sitagliptin may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Theophylline Theophylline The metabolism of Sitagliptin can be decreased when combined with Theophylline.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Indomethacin Indomethacin The excretion of Sitagliptin can be decreased when combined with Indomethacin.
Mefenamic Acid Mefenamic Acid The metabolism of Sitagliptin can be decreased when combined with Mefenamic acid.
Naproxen Naproxen Naproxen may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Isotretinoin Isotretinoin Isotretinoin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Floxuridine Floxuridine Floxuridine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Phenobarbital Phenobarbital The metabolism of Sitagliptin can be increased when combined with Phenobarbital.
Metaxalone Metaxalone Metaxalone may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection Methotrexate may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Methsuximide Methsuximide The risk or severity of hypoglycemia can be increased when Methsuximide is combined with Sitagliptin.
Chlorpromazine Chlorpromazine The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Chlorpromazine.
Diazepam Diazepam Diazepam may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Oxazepam Oxazepam Oxazepam may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Flurazepam Flurazepam Flurazepam may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Clorazepate Clorazepate Clorazepic acid may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Lorazepam Lorazepam Lorazepam may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Carmustine Carmustine Carmustine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Amantadine Amantadine Amantadine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Codeine Codeine Codeine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Bromocriptine Bromocriptine The risk or severity of hypoglycemia can be increased when Sitagliptin is combined with Bromocriptine.
Tranylcypromine Tranylcypromine Tranylcypromine may increase the hypoglycemic activities of Sitagliptin.
Phenelzine Phenelzine The metabolism of Sitagliptin can be decreased when combined with Phenelzine.
Procarbazine Procarbazine Procarbazine may increase the hypoglycemic activities of Sitagliptin.
Tetracycline Tetracycline The excretion of Sitagliptin can be decreased when combined with Tetracycline.
Minocycline Minocycline The excretion of Sitagliptin can be decreased when combined with Minocycline.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Dapsone Dapsone The metabolism of Sitagliptin can be decreased when combined with Dapsone.
Sulfadiazine Sulfadiazine The therapeutic efficacy of Sitagliptin can be increased when used in combination with Sulfadiazine.
Methadone Methadone The metabolism of Sitagliptin can be decreased when combined with Methadone.
Oxybutynin Oxybutynin The metabolism of Sitagliptin can be decreased when combined with Oxybutynin.
Benztropine Benztropine Benzatropine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Maprotiline Maprotiline Maprotiline may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Ibuprofen Ibuprofen The excretion of Sitagliptin can be decreased when combined with Ibuprofen.
Azathioprine Azathioprine Azathioprine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Phentermine Phentermine The therapeutic efficacy of Sitagliptin can be increased when used in combination with Phentermine.
Methylphenidate Methylphenidate Methylphenidate may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Amoxapine Amoxapine Amoxapine may decrease the hypoglycemic activities of Sitagliptin.
Sulfasalazine Sulfasalazine Sulfasalazine may increase the hypoglycemic activities of Sitagliptin.
Hydrocortisone Hydrocortisone The risk or severity of hyperglycemia can be increased when Hydrocortisone is combined with Sitagliptin.
Dactinomycin Dactinomycin The serum concentration of Sitagliptin can be increased when it is combined with Dactinomycin.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Carbamazepine Carbamazepine Sitagliptin may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
Methyldopa Methyldopa Methyldopa may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Hydralazine Hydralazine Sitagliptin may decrease the excretion rate of Hydralazine which could result in a higher serum level.
Cimetidine Cimetidine The excretion of Sitagliptin can be decreased when combined with Cimetidine.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Warfarin Warfarin Warfarin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Clonazepam Clonazepam Clonazepam may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Loperamide Loperamide The serum concentration of Sitagliptin can be increased when it is combined with Loperamide.
Promethazine Promethazine Promethazine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Sitagliptin can be increased when combined with Griseofulvin.
Digoxin Digoxin Sitagliptin may decrease the excretion rate of Digoxin which could result in a higher serum level.
Loxapine Loxapine The serum concentration of Sitagliptin can be increased when it is combined with Loxapine.
Chloroquine Chloroquine The metabolism of Sitagliptin can be decreased when combined with Chloroquine.
Quinine Quinine The serum concentration of Sitagliptin can be increased when it is combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of hypoglycemia can be increased when Ethosuximide is combined with Sitagliptin.
Triamterene Triamterene Triamterene may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Sulfinpyrazone Sulfinpyrazone The metabolism of Sitagliptin can be decreased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Chlorothiazide.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Chlorthalidone.
Metolazone Metolazone The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Metolazone.
Isosorbide Isosorbide Isosorbide may increase the excretion rate of Sitagliptin which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital Secobarbital The metabolism of Sitagliptin can be increased when combined with Secobarbital.
Desipramine Desipramine Desipramine may decrease the hypoglycemic activities of Sitagliptin.
Amitriptyline Amitriptyline The metabolism of Sitagliptin can be decreased when combined with Amitriptyline.
Imipramine Imipramine Imipramine may decrease the hypoglycemic activities of Sitagliptin.
Probenecid Probenecid The therapeutic efficacy of Sitagliptin can be increased when used in combination with Probenecid.
Quinidine Quinidine Sitagliptin may decrease the excretion rate of Quinidine which could result in a higher serum level.
Procainamide Procainamide Sitagliptin may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid Isoniazid may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Rifampin Rifampin The metabolism of Sitagliptin can be increased when combined with Rifampicin.
Disopyramide Disopyramide The risk or severity of hypoglycemia can be increased when Disopyramide is combined with Sitagliptin.
Valproic Acid Valproic Acid The metabolism of Sitagliptin can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The serum concentration of Sitagliptin can be increased when it is combined with Tamoxifen.
Butabarbital Butabarbital Butabarbital may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Levothyroxine Levothyroxine The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Levothyroxine.
Liothyronine Liothyronine The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Liothyronine.
Methimazole Methimazole Methimazole may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Chlorpropamide Chlorpropamide Sitagliptin may increase the hypoglycemic activities of Chlorpropamide.
Tolbutamide Tolbutamide Sitagliptin may increase the hypoglycemic activities of Tolbutamide.
Tolazamide Tolazamide Sitagliptin may increase the hypoglycemic activities of Tolazamide.
Dinoprostone Dinoprostone The excretion of Sitagliptin can be decreased when combined with Dinoprostone.
Niacin Niacin The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Niacin.
Baclofen Baclofen The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Baclofen.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Hydrochlorothiazide.
Chlorzoxazone Chlorzoxazone Chlorzoxazone may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Danazol Danazol The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Danazol.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The therapeutic efficacy of Sitagliptin can be increased when used in combination with Propranolol.
Pseudoephedrine Pseudoephedrine The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Pseudoephedrine.
Nortriptyline Nortriptyline Nortriptyline may decrease the hypoglycemic activities of Sitagliptin.
Spironolactone Spironolactone The metabolism of Sitagliptin can be decreased when combined with Spironolactone.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Mercaptopurine Mercaptopurine The excretion of Sitagliptin can be decreased when combined with Mercaptopurine.
Phytonadione Phytonadione Phylloquinone may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Nadolol Nadolol The therapeutic efficacy of Sitagliptin can be increased when used in combination with Nadolol.
Allopurinol Allopurinol Allopurinol may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Fluoxymesterone Fluoxymesterone Fluoxymesterone may increase the hypoglycemic activities of Sitagliptin.
Clomiphene Clomiphene The serum concentration of Sitagliptin can be increased when it is combined with Clomifene.
Flavoxate Flavoxate Flavoxate may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Fluorouracil Injection Fluorouracil Injection The metabolism of Sitagliptin can be decreased when combined with Fluorouracil.
Colchicine Colchicine The metabolism of Sitagliptin can be decreased when combined with Colchicine.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Dacarbazine Dacarbazine Dacarbazine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Acetazolamide Acetazolamide The therapeutic efficacy of Sitagliptin can be increased when used in combination with Acetazolamide.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Ketoconazole Ketoconazole The serum concentration of Sitagliptin can be increased when it is combined with Ketoconazole.
Pyrantel Pyrantel Sitagliptin may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Vincristine Injection Vincristine Injection The serum concentration of Vincristine can be increased when it is combined with Sitagliptin.
Captopril Captopril The risk or severity of angioedema can be increased when Sitagliptin is combined with Captopril.
Vinblastine Vinblastine The serum concentration of Sitagliptin can be increased when it is combined with Vinblastine.
Ethacrynic Acid Ethacrynic Acid The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Etacrynic acid.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Metoprolol Metoprolol The therapeutic efficacy of Sitagliptin can be increased when used in combination with Metoprolol.
Aspirin Aspirin The risk or severity of hypoglycemia can be increased when Acetylsalicylic acid is combined with Sitagliptin.
Salsalate Salsalate Salsalate may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Alprazolam Alprazolam Alprazolam may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Temazepam Temazepam Temazepam may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Triazolam Triazolam Triazolam may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Dicyclomine Dicyclomine Dicyclomine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Propantheline Propantheline Propantheline may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Trimethoprim Trimethoprim The metabolism of Sitagliptin can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The metabolism of Sitagliptin can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Sitagliptin can be decreased when combined with Nifedipine.
Timolol Timolol The therapeutic efficacy of Sitagliptin can be increased when used in combination with Timolol.
Verapamil Verapamil The serum concentration of Sitagliptin can be increased when it is combined with Verapamil.
Atenolol Atenolol The therapeutic efficacy of Sitagliptin can be increased when used in combination with Atenolol.
Pindolol Pindolol The therapeutic efficacy of Sitagliptin can be increased when used in combination with Pindolol.
Cisplatin Injection Cisplatin Injection Sitagliptin may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal Diflunisal may increase the hypoglycemic activities of Sitagliptin.
Piroxicam Piroxicam Piroxicam may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Bumetanide Bumetanide The therapeutic efficacy of Sitagliptin can be increased when used in combination with Bumetanide.
Etoposide Etoposide The serum concentration of Sitagliptin can be increased when it is combined with Etoposide.
Glyburide Glyburide The risk or severity of hypoglycemia can be increased when Glyburide is combined with Sitagliptin.
Glipizide Glipizide Sitagliptin may increase the hypoglycemic activities of Glipizide.
Indapamide Indapamide The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Indapamide.
Amoxicillin Amoxicillin Amoxicillin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Oxacillin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Pentoxifylline Pentoxifylline Pentoxifylline may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Pentamidine Injection Pentamidine Injection The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Pentamidine.
Ceftriaxone Injection Ceftriaxone Injection The excretion of Sitagliptin can be decreased when combined with Ceftriaxone.
Labetalol Labetalol The therapeutic efficacy of Sitagliptin can be increased when used in combination with Labetalol.
Auranofin Auranofin Auranofin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Leuprolide.
Gemfibrozil Gemfibrozil The metabolism of Sitagliptin can be decreased when combined with Gemfibrozil.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Enalapril Enalapril The risk or severity of angioedema can be increased when Enalapril is combined with Sitagliptin.
Flurbiprofen Flurbiprofen Flurbiprofen may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Sitagliptin.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Buspirone Buspirone Buspirone may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Lovastatin Lovastatin The metabolism of Sitagliptin can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The therapeutic efficacy of Sitagliptin can be increased when used in combination with Ciprofloxacin.
Mesalamine Mesalamine Mesalazine may increase the hypoglycemic activities of Sitagliptin.
Diclofenac Diclofenac Diclofenac may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Fluoxetine Fluoxetine The risk or severity of hypoglycemia can be increased when Fluoxetine is combined with Sitagliptin.
Nimodipine Nimodipine The risk or severity of hypoglycemia can be increased when Nimodipine is combined with Sitagliptin.
Clozapine Clozapine The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Clozapine.
Estazolam Estazolam Estazolam may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Ofloxacin Ofloxacin The therapeutic efficacy of Sitagliptin can be increased when used in combination with Ofloxacin.
Didanosine Didanosine Didanosine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Pentostatin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Clarithromycin Clarithromycin The serum concentration of Sitagliptin can be increased when it is combined with Clarithromycin.
Benazepril Benazepril The risk or severity of hypoglycemia can be increased when Benazepril is combined with Sitagliptin.
Etodolac Etodolac Etodolac may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Felodipine Felodipine The metabolism of Felodipine can be decreased when combined with Sitagliptin.
Fosinopril Fosinopril The risk or severity of angioedema can be increased when Fosinopril is combined with Sitagliptin.
Nabumetone Nabumetone Nabumetone may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Pravastatin Pravastatin The serum concentration of Sitagliptin can be increased when it is combined with Pravastatin.
Quinapril Quinapril The risk or severity of angioedema can be increased when Quinapril is combined with Sitagliptin.
Ramipril Ramipril The risk or severity of angioedema can be increased when Ramipril is combined with Sitagliptin.
Amlodipine Amlodipine The risk or severity of hypoglycemia can be increased when Amlodipine is combined with Sitagliptin.
Itraconazole Itraconazole The serum concentration of Sitagliptin can be increased when it is combined with Itraconazole.
Lisinopril Lisinopril The risk or severity of angioedema can be increased when Lisinopril is combined with Sitagliptin.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Rifabutin Rifabutin The metabolism of Sitagliptin can be increased when combined with Rifabutin.
Sotalol Sotalol The risk or severity of hypoglycemia can be increased when Sotalol is combined with Sitagliptin.
Bisoprolol Bisoprolol The therapeutic efficacy of Sitagliptin can be increased when used in combination with Bisoprolol.
Isradipine Isradipine The risk or severity of hypoglycemia can be increased when Isradipine is combined with Sitagliptin.
Omeprazole Omeprazole The metabolism of Sitagliptin can be decreased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Sitagliptin can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Sitagliptin can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The risk or severity of hypoglycemia can be increased when Venlafaxine is combined with Sitagliptin.
Fluvoxamine Fluvoxamine The risk or severity of hypoglycemia can be increased when Fluvoxamine is combined with Sitagliptin.
Nefazodone Nefazodone The risk or severity of hypoglycemia can be increased when Nefazodone is combined with Sitagliptin.
Lamotrigine Lamotrigine The risk or severity of hypoglycemia can be increased when Lamotrigine is combined with Sitagliptin.
Losartan Losartan The metabolism of Sitagliptin can be decreased when combined with Losartan.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Tramadol Tramadol Tramadol may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Moexipril Moexipril The risk or severity of angioedema can be increased when Moexipril is combined with Sitagliptin.
Lansoprazole Lansoprazole The excretion of Sitagliptin can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Sitagliptin can be increased when combined with Ifosfamide.
Nicardipine Nicardipine The metabolism of Sitagliptin can be decreased when combined with Nicardipine.
Bupropion Bupropion Bupropion may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Ticlopidine Ticlopidine Ticlopidine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Saquinavir Saquinavir The serum concentration of Saquinavir can be increased when it is combined with Sitagliptin.
Nisoldipine Nisoldipine The risk or severity of hypoglycemia can be increased when Nisoldipine is combined with Sitagliptin.
Lamivudine Lamivudine Lamivudine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Acarbose Acarbose The risk or severity of hypoglycemia can be increased when Acarbose is combined with Sitagliptin.
Glimepiride Glimepiride Sitagliptin may increase the hypoglycemic activities of Glimepiride.
Anastrozole Anastrozole The metabolism of Sitagliptin can be decreased when combined with Anastrozole.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Sitagliptin can be increased when it is combined with Gemcitabine.
Indinavir Indinavir The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Indinavir.
Ritonavir Ritonavir The serum concentration of Sitagliptin can be increased when it is combined with Ritonavir.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Meropenem Injection Meropenem Injection Meropenem may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Clomipramine Clomipramine Clomipramine may decrease the hypoglycemic activities of Sitagliptin.
Zafirlukast Zafirlukast The metabolism of Sitagliptin can be decreased when combined with Zafirlukast.
Fosfomycin Fosfomycin Fosfomycin may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Trandolapril Trandolapril The risk or severity of angioedema can be increased when Trandolapril is combined with Sitagliptin.
Topiramate Topiramate Topiramate may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Valsartan Valsartan The risk or severity of angioedema can be increased when Valsartan is combined with Sitagliptin.
Insulin Lispro Injection Insulin Lispro Injection Sitagliptin may increase the hypoglycemic activities of Insulin lispro.
Pramipexole Pramipexole Pramipexole may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Nelfinavir Nelfinavir The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Nelfinavir.
Fexofenadine Fexofenadine The serum concentration of Sitagliptin can be increased when it is combined with Fexofenadine.
Loratadine Loratadine The metabolism of Sitagliptin can be decreased when combined with Loratadine.
Carvedilol Carvedilol The therapeutic efficacy of Sitagliptin can be increased when used in combination with Carvedilol.
Nilutamide Nilutamide The metabolism of Sitagliptin can be decreased when combined with Nilutamide.
Flutamide Flutamide Flutamide may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Selegiline Selegiline The metabolism of Sitagliptin can be decreased when combined with Selegiline.
Sertraline Sertraline The risk or severity of hypoglycemia can be increased when Sertraline is combined with Sitagliptin.
Propafenone Propafenone The therapeutic efficacy of Sitagliptin can be increased when used in combination with Propafenone.
Raloxifene Raloxifene The metabolism of Sitagliptin can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Sitagliptin can be decreased when combined with Irbesartan.
Tamsulosin Tamsulosin The therapeutic efficacy of Sitagliptin can be increased when used in combination with Tamsulosin.
Quetiapine Quetiapine The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Quetiapine.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Cetirizine Cetirizine Cetirizine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Paroxetine Paroxetine The risk or severity of hypoglycemia can be increased when Paroxetine is combined with Sitagliptin.
Tolcapone Tolcapone Tolcapone may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Citalopram Citalopram The risk or severity of hypoglycemia can be increased when Citalopram is combined with Sitagliptin.
Capecitabine Capecitabine Capecitabine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Efavirenz Efavirenz The metabolism of Sitagliptin can be decreased when combined with Efavirenz.
Abacavir Abacavir Abacavir may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Sildenafil Sildenafil The serum concentration of Sildenafil can be increased when it is combined with Sitagliptin.
Pioglitazone Pioglitazone The metabolism of Sitagliptin can be decreased when combined with Pioglitazone.
Celecoxib Celecoxib The therapeutic efficacy of Sitagliptin can be increased when used in combination with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Sitagliptin can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine Tolterodine may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may increase the hypoglycemic activities of Sitagliptin.
Nateglinide Nateglinide The risk or severity of hypoglycemia can be increased when Nateglinide is combined with Sitagliptin.
Rabeprazole Rabeprazole The metabolism of Sitagliptin can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Sitagliptin can be decreased when combined with Terbinafine.

* This branded product is no longer on the market. Generic alternatives may be available.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists